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Ketosis AND Ketogenic

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https://www.readbyqxmd.com/read/30098269/low-fat-versus-ketogenic-diet-in-parkinson-s-disease-a-pilot-randomized-controlled-trial
#1
Matthew C L Phillips, Deborah K J Murtagh, Linda J Gilbertson, Fredrik J S Asztely, Christopher D P Lynch
BACKGROUND: Preliminary evidence suggests that diet manipulation may influence motor and nonmotor symptoms in PD, but conflict exists regarding the ideal fat to carbohydrate ratio. OBJECTIVES: We designed a pilot randomized, controlled trial to compare the plausibility, safety, and efficacy of a low-fat, high-carbohydrate diet versus a ketogenic diet in a hospital clinic of PD patients. METHODS: We developed a protocol to support PD patients in a diet study and randomly assigned patients to a low-fat or ketogenic diet...
August 11, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30073144/therapeutic-augmentation-of-ketogenic-diet-with-a-sodium-glucose-cotransporter-2-inhibitor-in-a-super-refractory-status-epilepticus-patient
#2
Joseph R Blunck, Joseph W Newman, Ronald K Fields, John E Croom
Background: A ketogenic diet (KD) may have a role in treating patients in super-refractory status epilepticus (SRSE). Sodium-glucose cotransporter 2 (SGLT2) inhibitors have a risk of ketoacidosis that could facilitate induction of KD. Case summary: A 42-year-old with a history of drug resistant epilepsy developed SRSE requiring several pharmacological interventions during her hospital course including the initiation of KD that failed. SGLT2 inhibitor therapy was initiated in a successful attempt to augment ketone production...
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/30037619/ketogenic-diet-for-schizophrenia-nutritional-approach-to-antipsychotic-treatment
#3
Adam Włodarczyk, Mariusz S Wiglusz, Wiesław Jerzy Cubała
Schizophrenia is a mental disorder that mostly appears in the second or third decade of life with no consistent appearance. The first-line pharmacological treatment are antipsychotic drugs, which mainly act by suppressing the activity of dopamine. Unfortunately many of schizophrenic patients suffer from persistent positive or negative symptoms that cannot be fully treated with available medication. With exploration on the possible causes of the disease there is evidence on dopaminergic transmission defects, there is a need to find more holistic way in treating the disease and a diet regimen could be one of them...
September 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/30021521/nutritional-ketosis-delays-the-onset-of-isoflurane-induced-anesthesia
#4
Csilla Ari, Zsolt Kovács, Cem Murdun, Andrew P Koutnik, Craig R Goldhagen, Christopher Rogers, David Diamond, Dominic P D'Agostino
BACKGROUND: Ketogenic diet (KD) and exogenous ketone supplements can evoke sustained ketosis, which may modulate sleep and sleep-like effects. However, no studies have been published examining the effect of ketosis on the onset of general isoflurane induced anesthesia. Therefore, we investigated the effect of the KD and different exogenous ketogenic supplements on the onset of akinesia induced by inhalation of isoflurane. METHODS: We used a high fat, medium protein and low carbohydrate diet (KD) chronically (10 weeks) in the glucose transporter 1 (GLUT1) deficiency (G1D) syndrome mice model and sub-chronically (7 days) in Sprague-Dawley (SPD) rats...
July 18, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29986720/efficacy-of-ketogenic-diet-on-body-composition-during-resistance-training-in-trained-men-a-randomized-controlled-trial
#5
RANDOMIZED CONTROLLED TRIAL
Salvador Vargas, Ramón Romance, Jorge L Petro, Diego A Bonilla, Ismael Galancho, Sergio Espinar, Richard B Kreider, Javier Benítez-Porres
BACKGROUND: Ketogenic diets (KD) have become a popular method of promoting weight loss. More recently, some have recommended that athletes adhere to ketogenic diets in order to optimize changes in body composition during training. This study evaluated the efficacy of an 8-week ketogenic diet (KD) during energy surplus and resistance training (RT) protocol on body composition in trained men. METHODS: Twenty-four healthy men (age 30 ± 4.7 years; weight 76.7 ± 8...
July 9, 2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29960852/improving-compliance-in-adults-with-epilepsy-on-a-modified-atkins-diet-a-randomized-trial
#6
Tanya J W McDonald, Bobbie J Henry-Barron, Elizabeth A Felton, Erie G Gutierrez, Joanne Barnett, Rebecca Fisher, MonYi Lwin, Amanda Jan, Diane Vizthum, Eric H Kossoff, Mackenzie C Cervenka
PURPOSE: To determine whether use of a ketogenic formula during the first month of the modified Atkins diet (MAD) in adults with drug-resistant epilepsy (DRE) improves seizure reduction and compliance compared to MAD alone. METHODS: Eighty adults (age ≥18 years) with DRE and ≥4 reliably quantifiable seizures/month were enrolled. All participants were trained to follow a 20 g/day net carbohydrate limit MAD. Patients were randomized to receive one 8-ounce (237 mL) tetrapak of KetoCal® , a 4:1 ketogenic ratio formula, daily in combination with MAD during the first month (treatment arm) or second month (control/cross-over arm)...
June 22, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29955649/feasibility-and-efficacy-data-from-a-ketogenic-diet-intervention-in-alzheimer-s-disease
#7
Matthew K Taylor, Debra K Sullivan, Jonathan D Mahnken, Jeffrey M Burns, Russell H Swerdlow
Introduction: We assessed the feasibility and cognitive effects of a ketogenic diet (KD) in participants with Alzheimer's disease. Methods: The Ketogenic Diet Retention and Feasibility Trial featured a 3-month, medium-chain triglyceride-supplemented KD followed by a 1-month washout in clinical dementia rating (CDR) 0.5, 1, and 2 participants. We obtained urine acetoacetate, serum β-hydroxybutyrate, food record, and safety data. We administered the Alzheimer's Disease Assessment Scale-cognitive subscale and Mini-Mental State Examination before the KD, and following the intervention and washout...
2018: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29951312/the-effect-of-medium-chain-triglycerides-on-time-to-nutritional-ketosis-and-symptoms-of-keto-induction-in-healthy-adults-a-randomised-controlled-clinical-trial
#8
Cliff J D C Harvey, Grant M Schofield, Micalla Williden, Joseph A McQuillan
Medium chain triglycerides (MCTs) are ketogenic and might reduce adverse effects of keto-induction and improve time to ketosis and the tolerability of very low carbohydrate diets. This study investigates whether MCT supplementation improves time to nutritional ketosis (NK), mood, and symptoms of keto-induction. We compared changes in beta-hydroxybutyrate (BOHB), blood glucose, symptoms of keto-induction, and mood disturbance, in 28 healthy adults prescribed a ketogenic diet, randomised to receive either 30 ml of MCT, or sunflower oil as a control, three times per day, for 20 days...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29910305/the-three-month-effects-of-a-ketogenic-diet-on-body-composition-blood-parameters-and-performance-metrics-in-crossfit-trainees-a-pilot-study
#9
Wesley C Kephart, Coree D Pledge, Paul A Roberson, Petey W Mumford, Matthew A Romero, Christopher B Mobley, Jeffrey S Martin, Kaelin C Young, Ryan P Lowery, Jacob M Wilson, Kevin W Huggins, Michael D Roberts
Adopting low carbohydrate, ketogenic diets remains a controversial issue for individuals who resistance train given that this form of dieting has been speculated to reduce skeletal muscle glycogen levels and stifle muscle anabolism. We sought to characterize the effects of a 12-week ketogenic diet (KD) on body composition, metabolic, and performance parameters in participants who trained recreationally at a local CrossFit facility. Twelve participants (nine males and three females, 31 ± 2 years of age, 80...
January 9, 2018: Sports
https://www.readbyqxmd.com/read/29883626/metabolism-and-epilepsy-ketogenic-diets-as-a-homeostatic-link
#10
Susan A Masino, Jong M Rho
Metabolic dysfunction can underlie seizure disorders, and metabolism-based treatments can afford seizure control and promote homeostasis. This relationship between metabolism and the risk of sporadic seizures was observed historically with the clinical success of a low-carbohydrate, high-fat, ketosis-inducing ketogenic diet - a treatment that remains relevant today, and one that has been shown to be effective against medically refractory epilepsy. Mechanisms underlying the success of the ketogenic diet are a topic of intense research efforts - not only because of proven success in arresting treatment-resistant seizures, but also because recent evidence suggests that altering metabolism with a ketogenic diet enables a homeostatic state in the brain that is less excitable, and hence raises the threshold for seizure genesis...
June 6, 2018: Brain Research
https://www.readbyqxmd.com/read/29872664/ketogenic-diet-in-refractory-childhood-epilepsy-starting-with-a-liquid-formulation-in-an-outpatient-setting
#11
Amerins Weijenberg, Margreet van Rijn, Petra M C Callenbach, Tom J de Koning, Oebele F Brouwer
Background: Ketogenic diet in children with epilepsy has a considerable impact on daily life and is usually adopted for at least 3 months. Our aim was to evaluate whether the introduction of an all-liquid ketogenic diet in an outpatient setting is feasible, and if an earlier assessment of its efficacy can be achieved. Methods: The authors conducted a prospective, observational study in a consecutive group of children with refractory epilepsy aged 2 to 14 years indicated for ketogenic diet...
2018: Child Neurology Open
https://www.readbyqxmd.com/read/29727818/efficacy-and-safety-of-ketogenic-diet-for-treatment-of-pediatric-convulsive-refractory-status-epilepticus
#12
Ravindra Arya, Katrina Peariso, Marina Gaínza-Lein, Jessica Harvey, Ann Bergin, J Nicholas Brenton, Brian T Burrows, Tracy Glauser, Howard P Goodkin, Yi-Chen Lai, Mohamad A Mikati, Iván Sánchez Fernández, Dmitry Tchapyjnikov, Angus A Wilfong, Korwyn Williams, Tobias Loddenkemper
PURPOSE: To describe the efficacy and safety of ketogenic diet (KD) for convulsive refractory status epilepticus (RSE). METHODS: RSE patients treated with KD at the 6/11 participating institutions of the pediatric Status Epilepticus Research Group from January-2011 to December-2016 were included. Patients receiving KD prior to the index RSE episode were excluded. RSE was defined as failure of ≥2 anti-seizure medications, including at least one non-benzodiazepine drug...
August 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29724763/%C3%AE-hydroxybutyrate-detection-with-proton-mr-spectroscopy-in-children-with-drug-resistant-epilepsy-on-the-ketogenic-diet
#13
J N Wright, R P Saneto, S D Friedman
BACKGROUND AND PURPOSE: The ketogenic diet, including both classic and modified forms, is an alternative to antiepileptic medications used in the treatment of drug-resistant epilepsy. We sought to evaluate the utility of proton MR spectroscopy for the detection of β-hydroxybutyrate in a cohort of children with epilepsy treated with the ketogenic diet and to correlate brain parenchymal metabolite ratios obtained from spectroscopy with β-hydroxybutyrate serum concentrations. MATERIALS AND METHODS: Twenty-three spectroscopic datasets acquired at a TE of 288 ms in children on the ketogenic diet were analyzed with LCModel using a modified basis set that included a simulated β-hydroxybutyrate resonance...
July 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29723773/different-ketogenesis-strategies-lead-to-disparate-seizure-outcomes
#14
Alison Dolce, Polan Santos, Weiran Chen, Ahmet Hoke, Adam L Hartman
BACKGROUND: Despite the introduction of new medicines to treat epilepsy over the last 50 years, the number of patients with poorly-controlled seizures remains unchanged. Metabolism-based therapies are an underutilized treatment option for this population. We hypothesized that two different means of systemic ketosis, the ketogenic diet and intermittent fasting, would differ in their acute seizure test profiles and mitochondrial respiration. METHODS: Male NIH Swiss mice (aged 3-4 weeks) were fed for 12-13 days using one of four diet regimens: ketogenic diet (KD), control diet matched to KD for protein content and micronutrients (CD), or CD with intermittent fasting (24 h feed/24 h fast) (CD-IF), tested post-feed or post-fast...
July 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29668317/the-modified-ketogenic-diet-in-adults-with-glioblastoma-an-evaluation-of-feasibility-and-deliverability-within-the-national-health-service
#15
Kirsty J Martin-McGill, Anthony G Marson, Catrin Tudur Smith, Michael D Jenkinson
There is an increasing interest in the use of the ketogenic diet (KD) as an adjuvant therapy for glioma patients. We assessed the tolerability and feasibility of a modified ketogenic diet (MKD) in patients with glioma, along with willingness of patients to participate in future randomized controlled trials. The study was undertaken in two parts; a patient questionnaire and evaluation of the diet. One hundred and seventy-two questionnaires were completed; 69% (n = 119) of the population reported MKD should be offered to patients with glioma and 73% (n = 125) would be willing to try MKD for 3 months...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29624009/the-concentration-of-free-amino-acids-in-blood-serum-of-dairy-cows-with-primary-ketosis
#16
J Marczuk, P Brodzki, A Brodzki, Ł Kurek
Ketosis is a common condition found in the initial stages of lactation in high-yielding dairy cows. The major cause of ketosis is a negative energy balance. During the energy deficiency, proteolysis processes develop parallel to lipolysis. During proteolysis, muscle tissue can be used as a source of amino acid. To date, the participation of amino acids in gluconeogenesis (glucogenic amino acids) and ketogenesis (ketogenic amino acids) has not been determined in detail. This paper presents the study on determination of the parameters of protein and free amino acid metabolism in blood serum of dairy cows with primary ketosis compared to healthy cows...
March 2018: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29610033/ketogenic-diet-therapy-in-infants-efficacy-and-tolerability
#17
Elaine Wirrell, Susan Eckert, Lily Wong-Kisiel, Eric Payne, Katherine Nickels
PURPOSE: This study evaluated tolerability and efficacy of the ketogenic diet in infants less than 12 months of age. METHODS: Infants less than 12 months of age, commencing the ketogenic diet between September 2007 and July 2016 were identified. Records were reviewed for epilepsy details, diet initiation details, efficacy and tolerability. RESULTS: Twenty-seven infants commenced the ketogenic diet (56% male, median age seven months). Median age at seizure onset was 1...
May 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29607218/nutritional-ketosis-and-mitohormesis-potential-implications-for-mitochondrial-function-and-human-health
#18
REVIEW
Vincent J Miller, Frederick A Villamena, Jeff S Volek
Impaired mitochondrial function often results in excessive production of reactive oxygen species (ROS) and is involved in the etiology of many chronic diseases, including cardiovascular disease, diabetes, neurodegenerative disorders, and cancer. Moderate levels of mitochondrial ROS, however, can protect against chronic disease by inducing upregulation of mitochondrial capacity and endogenous antioxidant defense. This phenomenon, referred to as mitohormesis, is induced through increased reliance on mitochondrial respiration, which can occur through diet or exercise...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29588985/ketogenic-parenteral-nutrition-in-17-pediatric-patients-with-epilepsy
#19
Anastasia Dressler, Nadja Haiden, Petra Trimmel-Schwahofer, Franz Benninger, Sharon Samueli, Gudrun Gröppel, Sina Spatzierer, Angelika Mühlebner, Klaus Abraham, Martha Feucht
Objective: Ketogenic parenteral nutrition (kPN) is indicated when enteral intake is temporarily limited or impossible, but evidence-based prescriptions are lacking. Objective was to evaluate the efficacy and safety of kPN in children with epileptic encephalopathies using a new computer-based algorithm for accurate component calculating. Methods: Children with epilepsy receiving kPN were included. A computer-based algorithm was established on the basis of guidelines of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN): fat intake not exceeding 4 g/kg/day, age-adequate supply of protein, electrolytes, vitamins, and trace elements, but reduced carbohydrates...
March 2018: Epilepsia open
https://www.readbyqxmd.com/read/29576959/the-use-of-nutritional-supplements-to-induce-ketosis-and-reduce-symptoms-associated-with-keto-induction-a-narrative-review
#20
Cliff J D C Harvey, Grant M Schofield, Micalla Williden
Background: Adaptation to a ketogenic diet (keto-induction) can cause unpleasant symptoms, and this can reduce tolerability of the diet. Several methods have been suggested as useful for encouraging entry into nutritional ketosis (NK) and reducing symptoms of keto-induction. This paper reviews the scientific literature on the effects of these methods on time-to-NK and on symptoms during the keto-induction phase. Methods: PubMed, Science Direct, CINAHL, MEDLINE, Alt Health Watch, Food Science Source and EBSCO Psychology and Behavioural Sciences Collection electronic databases were searched online...
2018: PeerJ
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