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https://www.readbyqxmd.com/read/30011257/therapeutic-efficacy-of-spherical-aggregated-human-bone-marrow-derived-mesenchymal-stem-cells-cultured-for-osteochondral-defects-of-rabbit-knee-joints
#1
Byung Hoon Lee, Jong Nam Park, Eun Ju Lee, Young Wan Moon, Joon Ho Wang
BACKGROUND: Engraftment and longevity of transplanted cells are crucial for stem cell-based cartilage treatment. PURPOSE: To determine whether cultured spherical cell masses of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) could improve engraftment at defect sites and to examine their corresponding effects on osteochondral regeneration. STUDY DESIGN: Controlled laboratory study. METHODS: A cylindrical osteochondral defect (5 mm wide × 5 mm deep) was created in trochlear grooves of rabbit knees...
July 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29995003/round-window-occlusion-affects-bone-conduction-in-cadaver-heads
#2
Keguang Chen, Huiying Lyu, Dongming Yin, Lin Yang, Tianyu Zhang, Peidong Dai
OBJECTIVE: To explore the feasibility of ear mold glue in the molding of round window occlusion (RWO) in cadaver heads and to study the effect on bone conduction (BC). METHODS: Ten cadaver heads were selected to establish RWO model. Ear mold glue was used to immobilize round window niche. The vibration properties of the stapes footplate (VST) in response to the acoustic stimulation, and the vibration properties of the stapes footplate and cochlear promontory (VCP) in response to the B-71 stimulation were assessed by laser Doppler vibrometer in both pre-RWO and post-RWO...
August 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29872877/-children-collect-bones-teaching-aids-and-propaganda-material-on-bone-collections-and-bone-utilisation-used-in-german-schools-during-the-third-reich
#3
Elisabeth Vaupel, Florian Preiß
In the nineteenth and early twentieth centuries bones were an essential raw material for the German chemical industry, vital to the production of fertilizer, glue, gelatine, soap and other products. As most of this material was imported, the German school system during the "Third Reich" took the utilisation of bones as an example to illustrate the relevance of the four-year plan of 1936 and its policy of economic self-sufficiency. The school children were encouraged to collect bones from domestic sources and bring them to the collecting points in the schools...
June 5, 2018: NTM
https://www.readbyqxmd.com/read/29868410/bone-marrow-aspirate-concentrate-and-microfracture-technique-for-talar-osteochondral-lesions-of-the-ankle
#4
Evelyn P Murphy, Christopher Fenelon, Niall P McGoldrick, Stephen R Kearns
Osteochondral lesions of the talus refer to a chondral or subchondral defect of the articular cartilage and potentially the underlying bone. Ankle sprains are an extremely common injury; approximately 27,000 ankle sprains occur per day in America. Fifty percent of these can lead to a cartilage injury to the ankle. There has been a high quoted rate of failure with conservative measures of up to 45% in some series. Surgical options are largely broken down into 2 groups, namely, reparative or regenerative treatments...
April 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29682010/craniofacial-trauma-in-pediatric-patients-following-winnowing-blade-injury-review-of-literature
#5
REVIEW
Harsha Huliyappa, Balakrishna Ojha, Anil Chandra, Sunil Kumar Singh, Chhitij Srivastava
In developing countries, during the harvest season, winnower blade injuries occur very frequently in children and results in lifelong disability. Nine children were managed during 1 month, all resulting due to winnower blade induced craniofacial trauma. PubMed search for "fan blade injury" showed two case series and three case reports. In our study, 88% had compound depressed fracture; brain matter leak in 56%, cerebrospinal fluid (CSF) leak alone in 22%. 66.7% had injury involving the frontal bone...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29651386/tissue-engineering-in-maxillary-bone-defects
#6
Azizollah Khodakaram-Tafti, Davood Mehrabani, Hanieh Shaterzadeh-Yazdi, Barbad Zamiri, Mahsa Omidi
BACKGROUND: Restoration of craniofacial bone defects has been a concern for oral and maxillofacial surgeons. In this study, the healing effect of fibrin glue scaffold was compared with autologous bone graft in mandibular defects of rabbit. METHODS: Bilateral unicortical osteotomy was performed in the diastema region of 10 male Dutch rabbits. The subjects were randomly divided into 2 equal groups. The mandibular defect on the right side was treated with fibrin glue scaffold and the defect on the left side with autologous bone graft provided from iliac crest...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29533334/application-of-regenerative-treatment-for-tympanic-membrane-perforation-with-cholesteatoma-tumor-or-severe-calcification
#7
Shin-Ichi Kanemaru, Rie Kanai, Misaki Yoshida, Yuji Kitada, Kaoru Omae, Shigeru Hirano
OBJECTIVE: To apply regenerative treatment for tympanic membrane (TM) perforation to patients with severe calcification of the TM, cholesteatomas, or tumors localized to the tympanic cavity. STUDY DESIGN: Controlled clinical pilot study. SETTING: General hospitals. PATIENTS: Forty-five patients (age: 8-85; M = 19, F = 26) were selected from patients with or without TM perforation for the regenerative treatment...
April 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29497572/engraftment-neuroglial-transdifferentiation-and-behavioral-recovery-after-complete-spinal-cord-transection-in-rats
#8
Luzzi Sabino, Crovace Alberto Maria, Lacitignola Luca, Valentini Valerio, Francioso Edda, Rossi Giacomo, Invernici Gloria, Galzio Renato Juan, Crovace Antonio
Background: Proof of the efficacy and safety of a xenogeneic mesenchymal stem cell (MSCs) transplant for spinal cord injury (SCI) may theoretically widen the spectrum of possible grafts for neuroregeneration. Methods: Twenty rats were submitted to complete spinal cord transection. Ovine bone marrow MSCs, retrovirally transfected with red fluorescent protein and not previously induced for neuroglial differentiation, were applied in 10 study rats (MSCG). Fibrin glue was injected in 10 control rats (FGG)...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29421855/leucocyte-and-platelet-rich-fibrin-block-for-bone-augmentation-procedure-a-proof-of-concept-study
#9
Simone Cortellini, Ana B Castro, Andy Temmerman, Jeroen Van Dessel, Nelson Pinto, Reinhilde Jacobs, Marc Quirynen
AIM: The objective of this proof-of-concept study was to investigate the effects of a new guided bone regeneration technique with a tissue engineering approach. MATERIALS AND METHODS: This single cohort observational study evaluated the outcome of the leucocyte- and platelet-rich fibrin (L-PRF) Block for horizontal bone augmentation in the maxilla. The L-PRF Block is prepared by mixing a particulated biomaterial with chopped L-PRF membranes at a 50:50 ratio and adding liquid fibrinogen to glue all together...
May 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29409182/matrix-associated-stem-cell-transplantation-mast-in-chondral-lesions-at-the-ankle-as-part-of-a-complex-surgical-approach-5-year-follow-up-in-100-patients
#10
Martinus Richter, Stefan Zech
BACKGROUND: The aim of the study was to assess the 5-year-follow-up after matrix-associated stem cell transplantation (MAST) in chondral lesions at the ankle as part of a complex surgical approach. METHODS: In a prospective consecutive non-controlled clinical follow-up study, all patients with chondral lesion at the ankle that were treated with MAST from April 1, 2009 to May 31, 2012 were included. Size and location of the chondral lesions, method-associated problems and the Visual-Analogue-Scale Foot and Ankle (VAS FA) before treatment and at follow-up were analysed...
December 12, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29408856/quick-and-easy-sample-preparation-without-resin-embedding-for-the-bone-quality-assessment-of-fresh-calcified-bone-using-fourier-transform-infrared-imaging
#11
Hiromi Kimura-Suda, Masahiko Takahata, Teppei Ito, Tomohiro Shimizu, Kyosuke Kanazawa, Masahiro Ota, Norimasa Iwasaki
Fourier transform infrared (FTIR) imaging is a powerful tool for the assessment of bone quality; however, it requires the preparation of thin bone sections. Conventional poly(methyl methacrylate) (PMMA) embedding for the preparation of sections takes more than two weeks and causes denaturation of the bone. Development of a quick and easy sample preparation technique without denaturation is needed for accurate clinical evaluation of fresh calcified bone using FTIR imaging. Frozen sectioning allows the quick and easy preparation of thin sections without denaturation, but it requires a substrate with good chemical resistance and improved heat shock resistance...
2018: PloS One
https://www.readbyqxmd.com/read/29388702/fibrin-glue-mediated-delivery-of-bone-anabolic-reagents-to-enhance-healing-of-tendon-to-bone
#12
Endre Soreide, Janet M Denbeigh, Eric A Lewallen, Rebekah M Samsonraj, Lawrence J Berglund, Amel Dudakovic, Simon M Cool, Lars Nordsletten, Sanjeev Kakar, Andre J van Wijnen
Tendon graft healing in bone tunnels for the fixation of intra-articular ligament reconstructions may limit clinical outcome by delaying healing. This study assesses the effects of hydrogel-mediated delivery of bone anabolic growth factors in a validated model of tendon-to-bone tunnel healing. Forty-five Wistar rats were randomly allocated into three groups (BMP2-treated, GSK126-treated, and placebo). All animals underwent a tendon-to-bone tunnel reconstruction. Healing was evaluated at 4 weeks by biomechanical assessment, micro-computed tomography (bone mineral density, bone volume, cross sectional area of bone tunnels), and traditional histology...
July 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29379374/comparative-analysis-of-conventional-and-biological-treatment-in-healing-of-bone-disease
#13
Wen-Zhe Guo, Hui Di, Guo-Hua Chu, Lu Lu
The healing of Bone tissue consists of a complex process. Hence, we designed our study to evaluate chondrial diseases, which are as they have a very low healing capacity. Seventy two elderly osteoarthritis (OA) and 54-paediatric juvenile idiopathic arthritis (JIA) patients were included. The group was divided as 24 OA patients and 18 JIA patients in each group. Group I received Hyualuronic acid and glucocorticoides. Group II received platelet rich plasma and fibrin glue. Group III received PRP, fibrin glue, and MSC...
January 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29349047/reduction-of-the-isolated-anterior-wall-of-the-maxillary-sinus-fracture-with-double-urinary-balloon-catheters-and-fibrin-glue
#14
Jaehee Kim, Ho Jik Yang, Jong Hwan Kim, Su Jin Kim
Background: Conservative treatment is performed for isolated anterior wall of the maxillary sinus fractures, in many cases when the fracture is clinically not severe and asymptomatic. Despite the absence of symptoms, complications such as sinusitis, rhinitis, and chronic purulent secretion may develop; therefore, successful reduction is required. We attempted to reduce the risk of complications using an alternative technique: reduction of the fracture with two urinary balloon catheters inserted through the maxillary ostium and fixation using fibrin glue, which minimizes the damage to the bony fragments and sinus mucosa...
December 2017: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29333367/stepwise-verification-of-bone-regeneration-using-recombinant-human-bone-morphogenetic-protein-2-in-rat-fibula-model
#15
Jung-Woo Nam, Hyung-Jun Kim
Objectives: The purpose of this study was to introduce our three experiments on bone morphogenetic protein (BMP) and its carriers performed using the critical sized segmental defect (CSD) model in rat fibula and to investigate development of animal models and carriers for more effective bone regeneration. Materials and Methods: For the experiments, 14, 16, and 24 rats with CSDs on both fibulae were used in Experiments 1, 2, and 3, respectively. BMP-2 with absorbable collagen sponge (ACS) (Experiments 1 and 2), autoclaved autogenous bone (AAB) and fibrin glue (FG) (Experiment 3), and xenogenic bone (Experiment 2) were used in the experimental groups...
December 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29284174/bilayer-matrix-autologous-chondrocyte-implantation-without-bone-graft-for-knee-osteochondral-lesion-less-than-8-mm-deep
#16
Murat Bozkurt, Cetin Isik, Safa Gursoy, Mustafa Akkaya, Oktay Algin, Metin Dogan
This article investigates the clinical and radiological results of bilayer matrix autologous chondrocyte implantation (MACI) membrane technique in the treatment of shallow osteochondral defects. An analysis was made of eight patients who were operated on using the bilayer MACI (Genzyme Biosurgery, Cambridge, MA) technique (mean age: 20.2 years, mean defect size: 3.8 cm2 , mean defect depth: 6.2 ± 0.9 mm, and mean follow-up time: 22.1 ± 5.3 [14-26.1] months). According to the defect, the first membrane was secured to the base of the defect with the cells facing up, and the second membrane was implanted on top of the first membrane with the cells facing down using fibrin glue...
December 28, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29283104/repair-of-tegmen-tympani-defect-presenting-with-spontaneous-cerebrospinal-fluid-otorrhea-using-the-middle-cranial-fossa-approach
#17
Said Sönmez, Bayram Şahin, Beldan Polat, Şenol Çomoğlu, Kadir Serkan Orhan
Spontaneous cerebrospinal fluid (CSF) otorrhea frequently occurs without temporal bone trauma, fracture, surgery, or any identifiable causes. It is usually associated with tegmen tympani defects of the temporal bone in adults. The congenital origin theory and the arachnoid granulation theory have been accepted to explain the tegmen tympani defect. Magnetic resonance imaging (MRI) and computed tomography (CT) are used to show the defects, brain tissue, and the meninges. We recently encountered three cases of spontaneous CSF otorrhea with a defect on the tegmental plate of the temporal bone...
December 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29250525/early-surgical-intervention-following-inguinal-hernia-repair-with-severe-postoperative-pain
#18
Ferdinand Köckerling, Christine Schug-Pass
Introduction: Severe postoperative pain is an important risk factor for onset of chronic inguinal pain following inguinal hernia repair. All measures must be taken to eliminate postoperative pain. Materials and methods: This case report highlights the problems of severe postoperative pain following transabdominal preperitoneal patch plasty (TAPP) inguinal hernia repair and describes a systematic treatment path that may include surgical intervention. Results: Following TAPP operation for lateral inguinal hernia, this patient who had been operated on in an external hospital still experienced intense, stabbing inguinal pain on postoperative day 7 during movement, despite optimal pain treatment...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/29202990/biological-reconstruction-of-large-osteochondral-lesions-of-the-talar-dome-with-a-modified-sandwich-technique-midterm-results
#19
Boguslaw Sadlik, Lukasz Kolodziej, Adrian Blasiak, Mateusz Szymczak, Bartłomiej Warchal
BACKGROUND: Surgical treatment for large osteochondral lesions of the talar dome (OLTD) must restore the convexity and curvature of the talus. Here, we present midterm results and describe the modified "sandwich" reconstruction procedure. Bone defects were restored using a biological inlay consists of autologous bone chips that were mixed with bone marrow concentrate and fibrin glue and covered with a xenogeneic collagen membrane infiltrated with bone marrow concentrate and stabilized by fibrin glue...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29202981/matrix-associated-stem-cell-transplantation-mast-in-chondral-defects-of-the-ankle-is-safe-and-effective-2-year-followup-in-130-patients
#20
Martinus Richter, Stefan Zech, Stefan Andreas Meissner
BACKGROUND: The aim of the study was to assess the 2-year-follow-up of matrix-associated stem cell transplantation (MAST) in chondral defects of the ankle. METHODS: In a prospective consecutive non-controlled clinical follow-up study, all patients with chondral defect that were treated with MAST from October 1, 2011 to July 31, 2013 were analyzed. Size and location of the chondral defects, method-associated problems and the Visual Analogue Scale Foot and Ankle (VAS FA) before treatment and at follow-up were analyzed...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
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