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https://www.readbyqxmd.com/read/30113815/significantly-accelerated-osteoblast-cell-growth-on-tio2-srha-composite-mediated-by-phenolic-compounds-bhm-from-hippocampus-kuda-bleeler
#1
Qiong Yuan, Lei He, Zhong-Ji Qian, Chunxia Zhou, Pengzhi Hong, Zhe Wang, Yi Wang, Shengli Sun, Chengyong Li
Microstructure of hydroxyapatite is known to influence cellular behavior, can be performed as a substrate for osteoblast growth, and exploited as a drug release platform. However, easy delamination and self-decomposition of hydroxyapatite caused by poor adhesion with substrates are the main problems currently. In this paper, we successfully fabricated TiO2/SrHA composite scaffolds by self-generated strontium substituted hydroxyapatite microspheres in TiO2 nanotubes. Moreover, the active compound 1-(5-bromo-2-hydroxy-methoxyphenyl)-ethanone (BHM) from Seahorse (Hippocampus kuda Bleeler) was loaded in this scaffold, and the controlled release kinetics of BHM was studied...
August 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30113419/comparison-of-mechanical-stabilization-of-the-mandibular-angulus-fracture-fixation-with-titanium-plates-and-screws-resorbable-plates-and-screws-and-bone-adhesives
#2
Ülkem Cural, Berkem Atalay, Mustafa Sami Yildirim
Mandibular fractures mostly occur at the angulus mandibula with a concurrent symphysis or corpus fracture on the opposite side. Misapplication can damage the nerves, adjacent teeth, soft tissues, and result in permanent tooth germs. In children, growth centers can be damaged, and this may result in asymmetry and retardation in growth and development. The aim of this study was to compare the mechanical stabilization after different techniques were used to create the mandibular angle fracture fixation and to create oblique fractures at mandible angles...
August 11, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30112006/wrist-arthrodesis-in-rheumatoid-arthritis-using-an-lcp-metaphyseal-locking-plate-versus-an-ao-wrist-fusion-plate
#3
Toshitake Taii, Takumi Matsumoto, Sakae Tanaka, Ichiro Nakamura, Katsumi Ito, Takuo Juji
Objectives: Although wrist arthrodesis using a plate is an established treatment with a well-documented successful union rate for severely destroyed wrists, plate-related complications are a matter of great concern. Methods: We retrospectively compared wrist arthrodesis using an AO wrist fusion plate in nine and a locking compression plate (LCP) metaphyseal plate in seven cases of rheumatoid arthritis. Results: The mean follow-up was 40.6 months in the AO wrist fusion plate group and 57...
2018: International Journal of Rheumatology
https://www.readbyqxmd.com/read/30110968/a-review-on-properties-of-natural-and-synthetic-based-electrospun-fibrous-materials-for-bone-tissue-engineering
#4
REVIEW
Deval Prasad Bhattarai, Ludwig Erik Aguilar, Chan Hee Park, Cheol Sang Kim
Bone tissue engineering is an interdisciplinary field where the principles of engineering are applied on bone-related biochemical reactions. Scaffolds, cells, growth factors, and their interrelation in microenvironment are the major concerns in bone tissue engineering. Among many alternatives, electrospinning is a promising and versatile technique that is used to fabricate polymer fibrous scaffolds for bone tissue engineering applications. Copolymerization and polymer blending is a promising strategic way in purpose of getting synergistic and additive effect achieved from either polymer...
August 14, 2018: Membranes
https://www.readbyqxmd.com/read/30110132/short-term-report-of-an-ongoing-prospective-cohort-study-evaluating-the-outcome-of-full-arch-implant-supported-fixed-hybrid-polyetheretherketone-acrylic-resin-prostheses-and-the-all-on-four-concept
#5
Paulo Maló, Miguel de Araújo Nobre, Carlos Moura Guedes, Ricardo Almeida, António Silva, Nuno Sereno, João Legatheaux
BACKGROUND: More research is needed on the study of new materials for fixed prosthetic implant-supported rehabilitations. PURPOSE: The purpose of this study was to report the short-term outcome of full-arch implant-supported fixed hybrid polyetheretherketone (PEEK)-acrylic resin prostheses and the all-on-four concept. MATERIALS AND METHODS: This prospective cohort clinical study included 37 patients (29 women, eight men) with an average age of 60 years (range: 38-78 years) with 49 full-arch hybrid PEEK-acrylic resin prosthesis supported by implants through the all-on-four concept...
August 15, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/30107340/controllable-and-durable-release-of-bmp-2-loaded-3d-porous-sulfonated-polyetheretherketone-peek-for-osteogenic-activity-enhancement
#6
Zhenjie Sun, Liping Ouyang, Xiaohan Ma, Yuqin Qiao, Xuanyong Liu
Polyetheretherketone (PEEK) is ideal for dental and orthopedic applications because its mechanical properties are similar to cortical bones. However, its inherent inert ability hinders its clinical applications. In this work, bone morphogenetic protein-2 (BMP-2) was immobilized onto the sulfonated PEEK (SPEEK) using lyophilization technology. The surface morphologies of the samples were analyzed by field-emission scanning electron microscopy (FE-SEM), and the chemical compositions were analyzed by energy-dispersive X-ray spectrometry (EDS)...
August 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30106454/estrogen-enhances-tumor-growth-and-angiogenesis-indirectly-via-mediation-of-bone-marrow%C3%A2-derived-cells-as-well-as-directly-through-stimulation-of-tumor-and-endothelial-cells
#7
Yingchen Zhuo, Xueqian Li, Qiaowei Zheng, Xingjun Fan, Wenbing Ma, Jingguo Chen, Xue Zhao, Peipei Zhao, Xuanlin Liu, Fengru Tang, Kai Cheng, Weiyi Feng
Estradiol (E2) is a prime culprit for enhancing the progression of female hormone‑related cancers. Bone marrow‑derived cells (BMDCs) have been found to play a pivotal role in tumor growth. Estrogen receptors (ERs) are also found on certain subtypes of BMDCs, in addition to endothelial cells (ECs) and certain tumor cells. However, the role of BMDCs in E2‑induced tumor biology is still unclear. Thus, the effects of E2 on ER‑negative 4T1 breast cancer growth, the mobilization and recruitment of BMDCs, and interactions among BMDCs, ECs, and 4T1 cells were investigated...
August 7, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30106161/microrna%C3%A2-34b-promotes-proliferation-migration-and-invasion-of-ewing-s-sarcoma-cells-by-downregulating-notch1
#8
Qunshan Lu, Mei Lu, Dong Li, Shuai Zhang
Ewing's sarcoma is the second most frequent bone and soft tissue sarcoma, which is commonly driven by the Ewing's sarcoma breakpoint region 1‑friend leukemia integration 1 transcription factor (EWS‑FLI1) fusion gene. Since microRNAs (miRs) can act as either oncogenes or tumor suppressor genes in human cancer, and miR‑34b has been reported to act as a tumor suppressor, the role of miR‑34b in Ewing's sarcoma was investigated in the present study. The results demonstrated that miR‑34b expression levels were higher in tumor samples compared within normal tissue samples...
August 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30102472/bmp-2-induces-human-mononuclear-cell-chemotaxis-and-adhesion-and-modulates-monocyte-to-macrophage-differentiation
#9
Evangelia Pardali, Lena-Maria Makowski, Merle Leffers, Andreas Borgscheiper, Johannes Waltenberger
Type 2 diabetes mellitus (T2DM) is a cardiovascular risk factor which leads to atherosclerosis, an inflammatory disease characterized by the infiltration of mononuclear cells in the vessel. Bone morphogenetic protein (BMP)-2 is a cytokine which has been recently shown to be elevated in atherosclerosis and T2DM and to contribute to vascular inflammation. However, the role of BMP-2 in the regulation of mononuclear cell function remains to be established. Herein, we demonstrate that BMP-2 induced human monocyte chemotaxis via phosphoinositide 3 kinase and mitogen-activated protein kinases...
August 13, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/30099813/a-computational-method-for-semi-automatic-measurement-of-pressure-ulcers
#10
Rodolfo H Silva, Alexei M C Machado
Pressure ulcers are skin lesions caused by the excessive compression of soft tissues between bones and hard surfaces that may increase treatment risks and costs. Manual techniques to evaluate the area of the affected region include the use of adhesive labels and rulers in direct contact with the ulcer. In this paper, a semi-automatic method is proposed to estimate the lesion area through computerized techniques in different color spaces using filters and morphological operators. Experiments with a set of 110 images of pressure ulcers resulted in a statistically significant increase in effectiveness, when compared to other published results, reaching 90...
August 12, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30098917/comparative-study-of-neoadjuvant-chemotherapy-with-and-without-zometa-for-management-of-locally-advanced-breast-cancer-with-serum-vegf-as-primary-endpoint-the-neozol-study
#11
Loïc Lelièvre, Philippe Clézardin, Laurent Magaud, Laurent Roche, Nicole Tubiana-Mathieu, Jean-Dominique Tigaud, Delphine Topart, Nadia Raban, Marie-Ange Mouret-Reynier, Patrice Mathevet
INTRODUCTION: Neoadjuvant chemotherapy has become the treatment of choice for locally advanced breast cancer. Zoledronic acid (ZA) is a bisphosphonate initially used in the treatment of bone metastases because of its antibone resorption effect. Antitumor effects of ZA, including the inhibition of cell adhesion to mineralized bone or the antiangiogenic effect, have been demonstrated. However, the clinical significance of these effects remains to be determined. MATERIALS AND METHODS: We undertook a multicenter open-label randomized trial to analyze the value of adding ZA to neoadjuvant chemotherapy for TNM clinical stage T2/T3 breast cancer...
July 10, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/30097518/sialidase-down-regulation-reduces-non-hdl-cholesterol-inhibits-leukocyte-transmigration-and-attenuates-atherosclerosis-in-apoe-knockout-mice
#12
Elizabeth J White, Gabriel Gyulay, Šárka Lhoták, Magdalena M Szewczyk, Taryne Chong, Mark T Fuller, Omid Dadoo, Alison E Fox-Robichaud, Richard C Austin, Bernardo Trigatti, Suleiman A Igdoura
Atherosclerosis is a complex disease that involves alterations in lipoprotein metabolism and inflammation. Protein and lipid glycosylation events, such as sialylation, contribute to the development of atherosclerosis and are regulated by specific glycosidases, including sialidases. To evaluate the effect of the sialidase neuraminidase 1 (NEU1) on atherogenesis, here we generated apolipoprotein E (ApoE)-deficient mice that express hypomorphic levels of NEU1 ( Neu1hypo Apoe-/- ). We found that the hypomorphic NEU1 expression in male Apoe-/- mice reduces serum levels of very-low-density lipoprotein (VLDL) and LDL cholesterol, diminishes infiltration of inflammatory cells into lesions, and decreases aortic sinus atherosclerosis...
August 10, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/30096434/f-2-isoprostanes-affect-macrophage-migration-and-csf-1-signalling
#13
J M Proudfoot, M W Murrey, S McLean, E L Greenland, A E Barden, K D Croft, J-M Galano, T Durand, T A Mori, F J Pixley
F2 -isoprostanes (F2 -IsoP) are formed in vivo via free radical peroxidation of arachidonic acid. Enhanced oxidative stress is implicated in the development of atherosclerosis in humans and F2 -IsoP have been detected in atherosclerotic plaque. Colony stimulating factor-1 (CSF-1) is essential to macrophage survival, proliferation and differentiation and has been detected in human atherosclerotic plaques. Accumulation of macrophages within the vascular wall is an important component of atherosclerosis but little is known about the effect of F2 -IsoP on the migration of these cells...
August 7, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30095599/protein-kinase-c-delta-pkc%C3%AE-tyrosine-phosphorylation-is-a-critical-regulator-of-neutrophil-endothelial-cell-interaction-in-inflammation
#14
Fariborz Soroush, Yuan Tang, Kimberly Guglielmo, Alex Engelmann, Elisabetta Liverani, Jordan Langston, Shuang Sun, Satya Kunapuli, Mohammad F Kiani, Laurie E Kilpatrick
BACKGROUND: Neutrophil dysfunction plays an important role in inflammation-induced tissue injury. Previously, we identified Protein Kinase C-delta (PKCδ) as a critical controller of neutrophil activation and trafficking but how PKCδ is regulated in inflammation hasn't been delineated. PKCδ activity is regulated by tyrosine phosphorylation on multiple sites. Tyrosine155 is a key regulator of apoptosis and gene expression, but its role in proinflammatory signaling is not known. METHODS: In vitro studies: superoxide anion (O2) and neutrophil extracellular traps (NETs) were measured in bone marrow neutrophils (BMN) isolated from wild type (WT) and PKCδY155F knock-in mice (PKCδ tyrosine 155 →phenylalanine)...
August 7, 2018: Shock
https://www.readbyqxmd.com/read/30094269/magnetic-resonance-imaging-parameters-at-1-year-correlate-with-clinical-outcomes-up-to-17-years-after-autologous-chondrocyte-implantation
#15
Helen S McCarthy, Iain W McCall, John M Williams, Claire Mennan, Marit N Dugard, James B Richardson, Sally Roberts
Background: The ability to predict the long-term success of surgical treatment in orthopaedics is invaluable, particularly in clinical trials. The quality of repair tissue formed 1 year after autologous chondrocyte implantation (ACI) in the knee was analyzed and compared with clinical outcomes over time. Hypothesis: Better quality repair tissue and a better appearance on magnetic resonance imaging (MRI) 1 year after ACI lead to improved longer-term clinical outcomes...
August 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/30094062/incorporation-of-silica-nanoparticles-to-plga-electrospun-fibers-for-osteogenic-differentiation-of-human-osteoblast-like-cells
#16
Xing Yang, Yuanyuan Li, Xujie Liu, Qianli Huang, Ranran Zhang, Qingling Feng
The development of bone tissue engineering scaffolds still remains a challenging field, although various biomaterials have been developed for this purpose. Electrospinning is a promising approach to fabricate nanofibers with an interconnected porous structure, which can support cell adhesion, guide cell proliferation and regulate cell differentiation. The aim of this study is to fabricate composite fibers composed of poly(lactic-co-glycolic acid) (PLGA) and silica nanoparticles (NPs) via electrospinning and investigate the effect of PLGA/SiO2 composite fibers on the cellular response of osteoblast-like cells (SaOS-2 cells)...
August 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/30093122/mechanical-integrity-of-cement-and-screw-retained-zirconium-lithium-silicate-glass-ceramic-crowns-to-morse-taper-implants
#17
Brendan R Vahey, Mariane B Sordi, Kyle Stanley, Ricardo S Magini, Antonio P Novaes de Oliveira, Márcio C Fredel, Bruno Henriques, Júlio C M Souza
STATEMENT OF PROBLEM: The improved esthetics of ceramic dental prostheses has increased their popularity, although their high elastic modulus and low fracture toughness and tensile strength may reduce the long-term performance of dental prostheses. PURPOSE: The purpose of this in vitro study was to assess the mechanical integrity of zirconium-lithium silicate glass-ceramic crowns cement- and screw-retained to a titanium implant-abutment after fatigue. MATERIAL AND METHODS: Forty titanium implants were placed in polyacetal to mimic bone support...
August 7, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/30091422/3d-printing-of-strontium-doped-hydroxyapatite-based-composite-scaffolds-for-repairing-critical-sized-rabbit-calvarial-defects
#18
Yun Luo, Shangsi Chen, Yufei Shi, Jun Ma
In this study, strontium substituted hydroxyapatite (Sr-HAP) was synthesized using collagen type I and citrate as bi-templates and the obtained nanoparticles with high similarity to natural bone minerals were made into composite scaffolds with inter-connected porous structure using a three-dimensional (3D) printing technique. A calcium-deficient structure of HAP phase was caused by doping Sr which was verified by FT-IR, XRD, SEM and TEM. The Sr/(Sr+Ca) molar ratio in Sr-HAP nanoparticles was 5.8% estimated by EDX...
August 9, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30088666/targeting-junctional-adhesion-molecule-c-ameliorates-sepsis-induced-acute-lung-injury-by-decreasing-cxcr4-aged-neutrophils
#19
Yohei Hirano, Yasumasa Ode, Mahendar Ochani, Ping Wang, Monowar Aziz
Sepsis is a severe inflammatory condition associated with high mortality. Transmigration of neutrophils into tissues increases their lifespan to promote deleterious function. Junctional adhesion molecule-C (JAM-C) plays a pivotal role in neutrophil transmigration into tissues. We aim to study the role of JAM-C on the aging of neutrophils to cause sepsis-induced acute lung injury (ALI). Sepsis was induced in C57BL/6J mice by cecal ligation and puncture (CLP) and JAM-C expression in serum was assessed. Bone marrow-derived neutrophils (BMDN) were treated with recombinant mouse JAM-C (rmJAM-C) ex vivo and their viability was assessed...
August 8, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/30088169/systemic-transplantation-of-mesenchymal-stem-cells-modulates-endothelial-cell-adhesion-molecules-induced-by-ovalbumin-in-rat-model-of-asthma
#20
Rana Keyhanmanesh, Reza Rahbarghazi, Mahdi Ahmadi
Achieving the optimal clinical outcome of mesenchymal stem cells (MSCs) is particularly dependent on fundamental understanding of therapeutic mechanisms. The current study was focused on the possible mechanisms by which rat bone marrow-derived mesenchymal stem cells (rBMMSCs) and/or conditioned media (CM) display broad immunomodulatory properties for ameliorating of asthma-related pathological changes. Male rats were divided equally into four experimental groups (n = 6): healthy rats received 50 μl PBS intravenously (group C), sensitized rats received 50 μl PBS intravenously (group OVA), sensitized rats received 50 μl CM intravenously (group OVA + CM), and sensitized rats received 50 μl PBS intravenously containing 2 × 106 rBMMSCs (group OVA + MSCs)...
August 7, 2018: Inflammation
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