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https://www.readbyqxmd.com/read/30511568/capsule-integrated-polypeptide-multilayer-films-for-effective-ph-responsive-multiple-drug-co-delivery
#1
Shichao Zhang, Malcolm M Q Xing, Bingyun Li
Many applications using drug-carrying biomedical materials require on-demand, localized delivery of multiple therapeutic agents in precisely controlled and patient-specific time sequences, especially after assembly of the delivery vehicles; however, creating such materials has proven extremely challenging. Here we report a novel strategy to create polypeptide multilayer films integrated with capsules as vehicles for co-delivery of multiple drugs using layer-by-layer self-assembly technology. Our approach allows the multilayered polypeptide nanofilms and pre-impregnated capsules to assemble into innovative biomedical materials with high and controllable loading of multiple drugs at any time post-preparation, and to achieve pH-responsive and sustained release...
December 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30511530/-research-progress-on-roles-of-vitamin-d-in-endometriosis
#2
Lifeng Zhang, Xinmei Zhang
In addition to regulating calcium and phosphorus metabolism to maintain strong bones, vitamin D also has immune regulating and anti-inflammatory effects. Moreover, it is related to chronic inflammatory diseases, autoimmune diseases and cancer. Many studies indicate the roles of vitamin D in the development and progression of endometriosis including the effects on modulation of immune responses, inflammation reactions, cell proliferation and apoptosis, angiogenesis, adhesion and invasion. Vitamin D supplementation can relieve pain and improve endometrial receptivity associated with endometriosis and play a preventive and therapeutic role...
February 25, 2018: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/30503059/development-of-a-demineralized-and-decellularized-human-epiphyseal-bone-scaffold-for-tissue-engineering-a-histological-study
#3
Elham Abedin, Roya Lari, Nasser Mahdavi Shahri, Masoud Fereidoni
Extracellular matrix (ECM) controls cellular behaviors such as proliferation, migration, and differentiation. The decellularized matrix of mammalian tissues has been used as a scaffold for the repair and reconstruction of tissue defects. In this study, for the first time demineralized and decellularized human epiphyseal bone matrix was used as a scaffold for a bone generation. Human epiphyseal bone was demineralized by hydrochloric acid and then decellularized by three methods of physical (slow freezing and snap freeze-thaw), enzymatic (trypsin 0...
December 2018: Tissue & Cell
https://www.readbyqxmd.com/read/30502449/tgf%C3%AE-i-is-involved-in-the-chondrogenic-differentiation-of-mesenchymal-stem-cells-and-is-dysregulated-in-osteoarthritis
#4
Maxime Ruiz, Marie Maumus, Guillaume Fonteneau, Yves-Marie Pers, Rosanna Ferreira, Louis Dagneaux, Christophe Delfour, Xavier Houard, Francis Berenbaum, François Rannou, Christian Jorgensen, Danièle Noël
OBJECTIVE: Transforming growth factor-β (TGFβ) is a major regulator of cartilage homeostasis and its deregulation has been associated with osteoarthritis (OA). Deregulation of the TGFβ pathway in mesenchymal stem cells (MSCs) has been proposed to be at the onset of OA. Using a secretome analysis, we identified a member of the TGFβ family, TGFβ-induced protein (TGFβi or βIGH3), expressed in MSCs and we investigated its function and regulation during OA. DESIGN: Cartilage, bone, synovium, infrapatellar fat pad and bone marrow-MSCs were isolated from patients with OA or healthy subjects...
November 28, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/30501071/osteogenesis-of-multipotent-progenitor-cells-using-the-epigallocatechin-gallate-modified-gelatin-sponge-scaffold-in-the-rat-congenital-cleft-jaw-model
#5
Satoshi Sasayama, Tomoya Hara, Tomonari Tanaka, Yoshitomo Honda, Shunsuke Baba
Cost-effective and functionalized scaffolds are in high demand for stem-cell-based regenerative medicine to treat refractory bone defects in craniofacial abnormalities and injuries. One potential strategy is to utilize pharmacological and cost-effective plant polyphenols and biocompatible proteins, such as gelatin. Nevertheless, the use of chemically modified proteins with plant polyphenols in this strategy has not been standardized. Here, we demonstrated that gelatin chemically modified with epigallocatechin gallate (EGCG), the major catechin isolated from green tea, can be a useful material to induce bone regeneration in a rat congenial cleft-jaw model in vivo when used with/without adipose-derived stem cells or dedifferentiated fat cells...
November 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30500741/photo-crosslinkable-bone-marrow-derived-mesenchymal-stem-cells-encapsulating-hydrogel-based-on-collagen-for-osteogenic-differentiation
#6
Tingting Zhang, Hong Chen, Yajie Zhang, Yue Zan, Tianyu Ni, Min Liu, Renjun Pei
Many patients suffer from bone injury and self-regeneration is not effective. Developing new strategies for effective bone injury repair is highly desired. Herein, collagen, an important component of the extracellular matrix, was modified with glycidyl methacrylate. The water solubility and photochemical cross-linking ability of the resulting collagen derivative was then improved. Thereafter, BMSC-laden hydrogel was fabricated using collagen modified with glycidyl methacrylate and hyaluronic acid modified with methacrylic anhydride under UV light in the presence of I 2959...
November 22, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30500448/compositionally-graded-doped-hydroxyapatite-coating-using-laser-and-plasma-spray-deposition
#7
Dongxu Ke, Ashley A Vu, Amit Bandyopadhyay, Susmita Bose
Plasma sprayed hydroxyapatite (HA) coating is known to improve the osteoconductivity of metallic implants. However, the adhesive bond strength of the coating is affected due to a mismatch in coefficients of thermal expansion (CTE) between the metal and the HA ceramic. In this study, a gradient HA coating was prepared on Ti6Al4V by laser engineered net shaping (LENSTM ) followed by plasma spray deposition. In addition, 1 wt.% MgO and 2 wt.% Ag2 O were mixed with HA to improve the biological and antibacterial properties of the coated implant...
November 27, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30497456/lanthanum-phosphate-chitosan-scaffolds-enhance-cytocompatibility-and-osteogenic-efficiency-via-the-wnt-%C3%AE-catenin-pathway
#8
Haoran Hu, Peipei Zhao, Jiayu Liu, Qinfei Ke, Changqing Zhang, Yaping Guo, Hao Ding
BACKGROUND: Fabrication of porous scaffolds with great biocompatibility and osteoinductivity to promote bone defect healing has attracted extensive attention. METHODS: In a previous study, novel lanthanum phosphate (LaPO4 )/chitosan (CS) scaffolds were prepared by distributing 40- to 60-nm LaPO4 nanoparticles throughout plate-like CS films. RESULTS: Interconnected three dimensional (3D) macropores within the scaffolds increased the scaffold osteoconductivity, thereby promoting cell adhesion and bone tissue in-growth...
November 29, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/30496806/polyphenols-in-the-prevention-and-treatment-of-periodontal-disease-a-systematic-review-of-in-vivo-ex-vivo-and-in-vitro-studies
#9
REVIEW
Kubra Bunte, Andreas Hensel, Thomas Beikler
Plant-derived polyphenols with antimicrobial and immunomodulatory characteristics appear to provide a variety of oral health benefits. Thus, the aim of the present study was to review the scientific literature to identify these effects of polyphenols on periodontal pathogens and inflammation. A MEDLINE search from 1st January 2013 to 18th January 2018 was performed to identify studies reporting polyphenol-containing plant extracts. Reports regarding pure compounds and essential oils, as well as effects on bacteria that are not defined as periodontal pathogens, were excluded...
November 26, 2018: Fitoterapia
https://www.readbyqxmd.com/read/30489453/hydrogen-sulfide-improves-vascular-repair-by-promoting-endothelial-nitric-oxide-synthase-dependent-mobilization-of-endothelial-progenitor-cells
#10
Qingsong Hu, Xiao Ke, Tao Zhang, Yangxin Chen, Qingsheng Huang, Bingqing Deng, Shuanglun Xie, Jingfeng Wang, Ruqiong Nie
BACKGROUND: Endothelial progenitor cells (EPCs) play a crucial role in endothelial repair after arterial injury. Hydrogen sulfide (H2S) is a novel gasotransmitter that regulates vascular homeostasis. METHOD: We investigated whether exogenous H2S could facilitate EPCs in repairing arterial injury. RESULTS: Sodium hydrosulfide (NaHS), a precursor of H2S, promoted re-endothelialization and inhibited neointima formation in a rodent carotid artery injury model...
November 27, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/30485718/enhanced-osteogenesis-of-bone-marrow-derived-mesenchymal-stem-cells-by-a-functionalized-silk-fibroin-hydrogel-for-bone-defect-repair
#11
Yufei Yan, Baochang Cheng, Kaizhe Chen, Wenguo Cui, Jin Qi, Xinming Li, Lianfu Deng
Silk fibroin (SF) from Bombyx mori is a promising natural material for the synthesis of biocompatible and biodegradable hydrogels for use in biomedical applications from tissue engineering to drug delivery. However, weak gelation performance and the lack of biochemical cues to trigger cell proliferation and differentiation currently significantly limit its application in these areas. Herein, a biofunctional hydrogel containing SF (2.0%) and a small peptide gelator (e.g., NapFFRGD = 1.0 wt%) is generated via cooperative molecular self-assembly...
November 28, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30485676/selection-of-the-optimum-3d-printed-pore-and-the-surface-modification-techniques-for-tissue-engineering-tracheal-scaffold-in-vivo-reconstruction
#12
Shu Pan, Yi Zhong, Yibo Shan, Xueying Liu, Yuanfan Xiao, Hongcan Shi
The influences of pore sizes and surface modifications on biomechanical properties and biocompatibility (BC) of porous tracheal scaffolds (PTSs) fabricated by polycaprolactone (PCL) using 3D printing technology. The porous grafts were surface-modified through hydrolysis, amination, and nanocrystallization treatment. The surface properties of the modified grafts were characterized by energy dispersive spectroscopy (EDS) and scanning electron microscopy (SEM). The materials were cocultured with bone marrow mesenchymal stem cells (BMSCs)...
November 28, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30485447/cartilage-tympanoplasty-combined-with-eustachian-tube-balloon-dilatation-in-the-treatment-of-adhesive-otitis-media
#13
Yu Si, Yubin Chen, Guo Xu, Ximing Chen, Wuhui He, Zhigang Zhang
OBJECTIVES/HYPOTHESIS: To investigate the simultaneous application of cartilage tympanoplasty combined with eustachian tube (ET) balloon dilatation in the treatment of adhesive otitis media (AdOM). STUDY DESIGN: Multicenter, prospective, double-blind, randomized, controlled clinical trial. METHODS: Patients with AdOM were randomly divided into four groups: control group (conservative treatment), ET balloon dilatation (ETBD) group, cartilage tympanoplasty (CT) group, and cartilage tympanoplasty combined with ET balloon dilatation (ETBD+CT) group...
November 28, 2018: Laryngoscope
https://www.readbyqxmd.com/read/30484958/up-regulation-of-spint2-hai-2-by-azacytidine-in-bone-marrow-mesenchymal-stromal-cells-affects-leukemic-stem-cell-survival-and-adhesion
#14
Fernanda Marconi Roversi, Nathalia Moreno Cury, Matheus Rodrigues Lopes, Karla Priscila Ferro, João Agostinho Machado-Neto, Marisa Claudia Alvarez, Gabriela Pereira Dos Santos, Renata Giardini Rosa, Ana Leda Longhini, Adriana da Silva Santos Duarte, Fernando Vieira Pericole, Patricia Favaro, José Andres Yunes, Sara Teresinha Olalla Saad
The role of tumour microenvironment in neoplasm initiation and malignant evolution has been increasingly recognized. However, the bone marrow mesenchymal stromal cell (BMMSC) contribution to disease progression remains poorly explored. We previously reported that the expression of serine protease inhibitor kunitz-type2 (SPINT2/HAI-2), an inhibitor of hepatocyte growth factor (HGF) activation, is significantly lower in BMMSC from myelodysplastic syndromes (MDS) patients compared to healthy donors (HD). Thus, to investigate whether this loss of expression was due to SPINT2/HAI-2 methylation, BMMSC from MDS and de novo acute myeloid leukaemia (de novo AML) patients were treated with 5-Azacitidine (Aza), a DNA methyltransferase inhibitor...
November 28, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/30483778/platelet%C3%A2-derived-growth-factor-d-promotes-the-angiogenic-capacity-of-endothelial-progenitor-cells
#15
Jianbo Zhang, Haolong Zhang, Yikuan Chen, Jian Fu, Yu Lei, Jianming Sun, Bo Tang
Neovascularization and re-endothelialization rely on endothelial progenitor cells (EPCs). However, the recruitment and angiogenic roles of EPCs are subject to regulation through the vascular microenvironment, which remains largely unknown. Platelet‑derived growth factor D (PDGF‑D) is a new member of the PDGF family that binds the PDGFR‑β homodimer. However, it remains unknown whether and how it affects the angiogenic capacity of EPCs and participates in tube‑like formation. EPCs were derived from rat bone marrow cells, and the gain‑of‑function approach was used to study the effects of PDGF‑D on the biological activities of EPCs...
November 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30482097/slc25a22-promotes-proliferation-and-metastasis-of-osteosarcoma-cells-via-the-pten-signaling-pathway
#16
Ming-Wei Chen, Xue-Jian Wu
Osteosarcoma is a highly malignant bone tumor. However, due to the high complexity of the occurrence and metastasis of osteosarcoma, the exact mechanism promoting its development and progression remains to be elucidated. This study highlights the causal link between solute carrier family 25 member 22 (SLC25A22) and the development, progression, and metastasis of osteosarcoma. SLC25A22 is upregulated in human osteosarcoma and predicts a poor prognosis. The upregulation of SLC25A22 in osteosarcoma tissues was significantly associated with cell proliferation, invasion, and metastasis...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/30482034/endoscopic-and-radiologic-findings-in-failed-dacryocystorhinostomy-teaching-pearls-for-success
#17
Islam R Herzallah, Osama A Marglani, Sumaiya H Muathen, Arwa A Obaid
BACKGROUND: Although several studies have commented on causes of dacryocystorhinostomy (DCR) failure, detailed description of anatomical findings in such cases remains insufficient. OBJECTIVE: Our objective was primarily to analyze radiologic, endoscopic, and intraoperative findings in patients presenting with failed DCR and secondarily to assess the outcome of revision endoscopic DCR (endo-DCR) carried out at our institution. METHODS: Twenty-four failed DCRs presenting to our tertiary care center were retrospectively analyzed...
November 28, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/30480804/preparation-of-adriamycin-gelatin-microsphere-loaded-decellularized-periosteum-that-is-cytotoxic-to-human-osteosarcoma-cells
#18
Chuan Chen, Jianghui Dong, Hong Chen, Xin Wang, Jin Mei, Liping Wang, Cory J Xian
The purpose of this study was to develop a novel approach to treat bone osteosarcoma using a multipurpose scaffold aiming for local drug delivery. The slowly releasing microspheres was designed to deliver the chemotherapy drug adriamycin (ADM) and a decellularized (D) periosteum scaffold (which is known to be able to promote bone regeneration) was used to carry these microspheres. D-periosteum was obtained by physical and chemical decellularization. Histological results showed that the cellular components were effectively removed...
November 27, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30475576/collagen-functionalized-with-graphene-oxide-enhanced-biomimetic-mineralization-and-in-situ-bone-defect-repair
#19
Chuchao Zhou, Shaokai Liu, Jialun Li, Ke Guo, Quan Yuan, Aimei Zhong, Jie Yang, Jiecong Wang, Jiaming Sun, Zhenxing Wang
Biomimetic mineralization using simulated body fluid (SBF) can form a bone-like apatite (Ap) on the natural polymers and enhance osteoconductivity, biocompatibility and reduce immunological rejection. Nevertheless, the coating efficiency of bone-like apatite layer on natural polymers is still needed to be improved. Graphene oxide (GO) is rich in functional groups, such as carbonyls (-COOH) and hydroxyls (-OH), which can provide more active sites for biomimetic mineralization and improve the proliferation of the rat bone marrow stromal cells (r-BMSCs)...
November 26, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30470573/self-healing-and-injectable-hybrid-hydrogel-for-bone-regeneration-of-femoral-head-necrosis-and-defect
#20
Yingjie Wang, Wei Zhu, Ke Xiao, Zeng Li, Qi Ma, Weifeng Li, Songpo Shen, Xisheng Weng
BACKGROUND: HA modified by bisphosphonate (BP) (HA-BP) was synthesized by chemical reaction and possessed promising properties such as self-healing, injection ability, and strong adhesion. The main aim of this study was to confirm its role in promoting osteogenic differentiation in vitro and bone regeneration in vivo. METHODS: The cell biocompatibility of this material was determined using the CCK-8 assay. Alkaline phosphatase (ALP), osteocalcin (OT), vascular endothelial growth factor (VEGF), and collagen I were assessed by quantitative real-time polymerase chain reaction (Q-PCR) in the treated group...
November 20, 2018: Biochemical and Biophysical Research Communications
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