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https://www.readbyqxmd.com/read/30342285/osteoblast-responses-to-injectable-bone-substitutes-of-kappa-carrageenan-and-nano-hydroxyapatite
#1
Jazmín I González Ocampo, Mirian M Machado de Paula, Nicole J Bassous, Anderson O Lobo, Claudia P Ossa Orozco, Thomas J Webster
The combination of kappa-carrageenan (κ-CG) and hydroxyapatite (HA) to generate a bone substitute material has been underexplored to date. Carrageenans (CGs) have remarkable characteristics such as biocompatibility, hydrophilicity, and structural similarities with natural glycosaminoglycans (GAGs), and they have demonstrated the ability to stimulate cellular adhesion and proliferation. Hydroxyapatite nanoparticles have been one of the most investigated materials for bone regeneration due to their excellent biocompatibility, bioactivity and osteoconductivity...
October 17, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30340179/fabrication-of-hydroxyapatite-hydrophilic-graphene-composites-and-their-modulation-to-cell-behavior-toward-bone-reconstruction-engineering
#2
Pengjun Wang, Tengbo Yu, Qiulan Lv, Shaoke Li, Xuexiao Ma, Guanpin Yang, Daxing Xu, Xiu Liu, Guangtao Wang, Zeqing Chen, Shi-Chao Xing
Cell adhesion was the first step of bone reconstruction. While hydroxyapatite (HA)/graphene composites had been utilized for improving the cell adhesion and bone osteogenesis, the impact of cell adhesion and HA/graphene composites, especially HA/hydrophilic graphene (HG) composites, on internal interaction force and external surface properties remained poorly understood. Here, higher stability HA/HG composites were synthesized without extra ion introduction with in situ self-assembling method. And with XRD, FT-IR, XPS and Raman analyses, the evidences of the formation of HA and the introduction of HG was clear...
October 10, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30334962/the-distinguishable-dna-whole-genome-methylation-profile-of-2-cases-of-pediatric-precursor-b-acute-lymphoblastic-leukaemia-bcp-all-with-prodromal-preleukemic-phase-a-case-report
#3
Radosław Chaber, Artur Gurgul, Grażyna Wróbel, Anna Tomoń, Sylwia Paszek, Natalia Potocka, Olga Haus, Monika Lejman, Kornelia Łach, Tomasz Szmatoła, Igor Jasielczuk, Blanka Rybka, Renata Ryczan-Krawczyk, Sylwia Stąpor, Krzysztof Ciebiera, Christopher J Arthur, Izabela Zawlik
RATIONALE: A prolonged, prodromal phase before definitive paediatric precursor B acute lymphoblastic leukaemia (BCP ALL) diagnosis is rarely observed. PATIENTS CONCERNS: In the first, the patient presented with an aplastic preleukemic phase, whilst the second presented with a rheumatic-like preliminary phase. DIAGNOSES: The case reports of two patients with BCP ALL with a prodromal phase lasting a few weeks are presented. INTERVENTIONS AND OUTCOMES: DNA whole genome profile methylation analysis of bone marrow cells obtained at diagnosis revealed a pattern of methylation that was readily distinguishable from both healthy and standard course BCP ALL bone marrow samples...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30334373/euxanthone-impairs-the-metastatic-potential-of-osteosarcoma-by-reducing-cox-2-expression
#4
Xiaodong Chen, Min Deng, Xinshe Zhou, Xuyi Wang, Yuchen Ye, Jun Zhu, Huafeng Jiang, Xiaotian Chen, Wenju Zha
OBJECTIVE: Osteosarcoma (OS) is one of the most common malignancies of bone. This study was aimed to explore the anti-metastatic effect of euxanthone on OS. MATERIALS AND METHODS: Adhesion assay and Transwell assay were used to examine the effect of euxanthone on adhesion, migration and invasion of OS cells. COX-2-over-expressing plasmid was applied to transfect OS cells to assess whether COX-2 affects the anti-metastatic function of euxanthone. PDCD4 knockdown and miR-21 mimic were applied to assess whether euxanthone suppresses the transactivation of c-jun via modulating miR-21-PDCD4 signaling...
October 17, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/30333796/preferential-colonization-of-osteoblasts-over-co-cultured-bacteria-on-a-bifunctional-biomaterial-surface
#5
Linyang Chu, Ying Yang, Shengbing Yang, Qiming Fan, Zhifeng Yu, Xi-Le Hu, Tony D James, Xiao-Peng He, Tingting Tang
Implant-related infection is a devastating complication in clinical trauma and orthopedics. The aim of this study is to use a bifunctional biomaterial surface in order to investigate the competitive colonization between osteoblasts and bacteria, which is the cause of implant-related infection. A bone-engineering material capable of simultaneously facilitating osteoblast adhesion and inhibiting the growth of Staphylococcus aureus ( S. aureus ) was prepared. Then, three different co-cultured systems were developed in order to investigate the competitive colonization between the two cohorts on the surface...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30326614/-de-novo-transcriptome-sequencing-analysis-of-goose-anser-anser-embryonic-skin-and-the-identification-of-genes-related-to-feather-follicle-morphogenesis-at-three-stages-of-development
#6
Chang Liu, Cornelius Tlotliso Sello, Yongfeng Sun, Yuxuan Zhou, Hongtao Lu, Yujian Sui, Jingtao Hu, Chenguang Xu, Yue Sun, Jing Liu, Shengyi Li, Yiming Zhang, Kaiyan Zhang
The objective of this study was to evaluate the changes in the goose embryo transcriptome during feather development. RNA-Sequencing (RNA-Seq) was used to find the transcriptome profiles of feather follicles from three stages of embryonic dorsal skin at embryonic day 13, 18, and 28 (E13, E18, E28). The results showed that 3001, 6634, and 13,780 genes were differently expressed in three stages. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that differentially expressed genes (DEGs) in E13 vs...
October 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30321630/pore-size-directs-bone-marrow-stromal-cell-fate-and-tissue-regeneration-in-nanofibrous-macroporous-scaffolds-by-mediating-vascularization
#7
Melanie J Gupte, W Benton Swanson, Jiang Hu, Xiaobing Jin, Haiyun Ma, Zhanpeng Zhang, Zhongning Liu, Kai Feng, Ganjun Feng, Guiyong Xiao, Nan Hatch, Yuji Mishina, Peter X Ma
In the U.S., 30% of adults suffer joint pain, most commonly in the knee, which severely limits mobility and is often attributed to injury of cartilage and underlying bone in the joint. Current treatment methods such as microfracture result in less resilient fibrocartilage with eventual failure; autografting can cause donor site morbidity and poor integration. To overcome drawbacks in treatment, tissue engineers can design cell-instructive biomimetic scaffolds using biocompatible materials as alternate therapies for osteochondral defects...
October 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30318728/breath-figures-decorated-silicon-oxinitride-ceramic-surfaces-with-controlled-si-ions-release-for-enhanced-osteoinduction
#8
Cristiano Carlomagno, Antonella Motta, Giandomenico Sorarù, Pranesh Aswath, Claudio Migliaresi, Devid Maniglio
Bioactive coatings are usually applied to bone and dental prostheses to enhance the integration and their stability in the bone. Recently, silicon (Si) oxynitride ceramics have been demonstrated to possess osteoconductive properties due to the release of Si ions, particularly important in the early stage of bone formation. In addition, the pattern of the bone contacting surface has been reported to affect cells' differentiation and metabolic activity. In this work, we propose the Breath Figure (BF) process combined with a pyrolysis step, starting from a photo-crosslinkable alkoxy silicone precursor, as a method to realize bioactive patterned coating on metal bone and dental prostheses...
October 14, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30318236/one-step-fabrication-of-apatite-chitosan-scaffold-as-a-potential-injectable-construct-for-bone-tissue-engineering
#9
Kaushar Jahan, Mina Mekhail, Maryam Tabrizian
Biomineralization of soft scaffolds is a new venture in bone tissue engineering. This work aimed to develop a new injectable and in-situ gelling soft scaffold with chitosan and apatites through a rapid purine-crosslinking reaction. The scaffolds were fabricated by mixing chitosan, adenosine diphosphate and biominerals in an 'all-in-one-step' procedure. The gelling of chitosan via the crosslinker occurs in <4 s as measured by impedance spectroscopy. These soft gels could retain up to 4 times their weight in water...
January 1, 2019: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30317552/sema3b-as1-inhibited-osteogenic-differentiation-of-human-mesenchymal-stem-cells-revealed-by-quantitative-proteomics-analysis
#10
Chen Zhang, Yun Zhu, Yugang Liu, Xiguang Zhang, Qiaoning Yue, Li Li, Yatang Chen, Sheng Lu, Zhaowei Teng
Human mesenchymal stem cells (hMSCs) are fibroblastoid multipotent adult stem cells with capacities of differentiation into osteoblasts and chondrocytes and show great potential in new bone formation and bone repair-related clinical settings, such as osteoporosis. Long noncoding RNAs (lncRNAs) have been demonstrated to play important roles in various biological processes. Here, we report an antisense lncRNA SEMA3B-AS1 regulating hMSCs osteogenesis. SEMA3B-AS1 is proximal to a member of the semaphorin family Sema3b...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30315883/role-of-rack1-on-cell-proliferation-adhesion-and-bortezomib-induced-apoptosis-in-multiple-myeloma
#11
Linlin Zhang, Ya Xu, Li Wang, Hong Liu
Receptor for activated C kinase 1 (RACK1), a scaffold protein, plays a crucial role in the progression of various cancers. However, the biological function and underlying mechanism of RACK1 in multiple myeloma (MM) cells remain unclear. The present study aimed to explore the function of RACK1 on the cell proliferation, adhesion, and bortezomib-induced apoptosis in MM. We found that RACK1 was significantly overexpressed in myeloma cell lines and primary myeloma cells compared with normal bone marrow plasma cells...
October 10, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30308455/the-effects-of-blood-conditioning-films-on-the-antimicrobial-and-retention-properties-of-zirconium-nitride-silver-surfaces
#12
Anthony J Slate, David Wickens, Joels Wilson-Nieuwenhuis, Nina Dempsey-Hibbert, Glen West, Peter Kelly, Joanna Verran, Craig E Banks, Kathryn A Whitehead
External bone fixation devices provide support and rehabilitation for severely damaged/broken bones, however, this invasive procedure is prone to infection. Zirconium nitride/silver (Ti-ZrN/Ag) coatings were characterised for surface topography, chemical composition, physicochemistry and antimicrobial efficacy (against Staphylococcus aureus and Staphylococcus epidermidis), in the presence of a blood conditioning film. The conditioning film altered the width of the microtopography of the surfaces however, the depth of the features remained relatively constant...
September 26, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30305209/self-assembled-hydroxyapatite-graphene-scaffold-for-photothermal-cancer-therapy-and-bone-regeneration
#13
Dejian Li, Wei Nie, Liang Chen, David McCoul, Dinghua Liu, Xu Zhang, Ying Ji, Baoqing Yu, Chuanglong He
Repairing large tumor-related bone defects remains a difficult clinical problem because of the significant risk of locoregional relapse after surgical curettage. In this study, a composite scaffold of nano-hydroxyapatite (nHA) and reduced graphene oxide (rGO) sheets was fabricated by self-assembly, and a 20 wt% nHA-rGO sheet solution formed the most stable hydrogel. In vitro , nHA-rGO scaffolds killed all but 8% of osteosarcoma cells (MG-63) under 808 nm near-infrared laser irradiation for 20 min. SEM images and live/dead staining of MG-63 cells in nHA-rGO also confirmed the therapeutic efficacy of the scaffolds...
December 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30298138/inflammatory-driven-angiogenesis-in-bone-augmentation-with-bovine-hydroxyapatite-b-tricalcium-phosphate-and-bioglasses-a-comparative-study
#14
Vlad M Anghelescu, Ioana Neculae, Octavian Dincă, Cristian Vlădan, Claudiu Socoliuc, Mirela Cioplea, Luciana Nichita, Cristiana Popp, Sabina Zurac, Alexandru Bucur
Introduction: The clinical use of bioactive materials for bone augmentation has remained a challenge because of predictability and effectiveness concerns, as well as increased costs. The purpose of this study was to analyse the ability to integrate bone substitutes by evaluating the immunohistochemical expression of the platelet endothelial cell adhesion molecules, vascular endothelial growth factor, collagen IV, laminin, and osteonectin, in the vicinity of bone grafts, enabling tissue revascularization and appearance of bone lamellae...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30292679/micro-patterning-of-hydroxyapatite-by-soft-lithography-on-hydrogels-for-selective-osteoconduction
#15
Ryuji Kiyama, Takayuki Nonoyama, Susumu Wada, Shingo Semba, Nobuto Kitamura, Tasuku Nakajima, Takayuki Kurokawa, Kazunori Yasuda, Shinya Tanaka, Jian Ping Gong
Mechanically robust hydrogels are promising biomaterials as artificial supportive tissue. These applications require selective and robust bonding of the hydrogels to living tissue. Recently, we achieved strong in vivo bone bonding of a tough double network (DN) hydrogel, a potential material for use as artificial cartilage and tendon, by hybridizing osteoconductive hydroxyapatite (HAp) in the gel surface layer. In this work, we report micro patterning of HAp at the surface of the DN hydrogel for selective osteoconduction...
October 5, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30291461/rankl-induced-c-src-activation-contributes-to-conventional-anti-cancer-drug-resistance-and-dasatinib-overcomes-this-resistance-in-rank-expressing-multiple-myeloma-cells
#16
Keiji Mashimo, Masanobu Tsubaki, Tomoya Takeda, Ryota Asano, Minami Jinushi, Motohiro Imano, Takao Satou, Katsuhiko Sakaguchi, Shozo Nishida
The survival and growth of multiple myeloma (MM) cells are facilitated by cell-cell interactions with bone marrow stromal cells and the bone marrow microenvironment. These interactions induce de novo drug resistance known as cell adhesion-mediated drug resistance. Our previous results recently revealed that the receptor activator of NF-κB (RANK) ligand (RANKL), which is expressed by bone marrow stromal cells, contributes to anti-cancer drug resistance through the activation of various signaling molecules and suppression of Bim expression in RANK-expressing MM cells...
October 5, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/30287720/nonsurgical-management-and-2-year-follow-up-by-means-of-cone-beam-computed-tomography-of-an-invasive-cervical-resorption-in-a-molar
#17
Mohammed Mashyakhy, Hemant R Chourasia, Esam Halboub, Rafael A Roges, Gianluca Gambarini
BACKGROUND: Invasive cervical resorption (ICR) is a relatively uncommon form of external tooth resorption, characterized by an invasive nature. It is usually painless and detection of lesions is often made incidentally. Three-dimensional imaging techniques, such as cone beam computed tomography (CBCT), are useful in the diagnosis and management of ICR as the true extent of the defect cannot always be estimated using conventional radiographs. AIM: The aim of this article is to report on the successful treatment of ICR in mandibular first molar by nonsurgical approach and follow-up by means of CBCT...
September 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/30287045/macroporous-alginate-foams-crosslinked-with-strontium-for-bone-tissue-engineering
#18
Ovidio Catanzano, Alessandra Soriente, Annalisa La Gatta, Marcella Cammarota, Giulia Ricci, Ines Fasolino, Chiara Schiraldi, Luigi Ambrosio, Mario Malinconico, Paola Laurienzo, Maria Grazia Raucci, Giovanna Gomez d'Ayala
Nowadays, the need of novel strategies to repair and regenerate bone defects in the field of biomedical applications has increased. Novel approaches include the design of natural bioactive scaffolds mimicking bone tissue. These bioactive scaffolds have to possess biophysical properties suitable to address biological response towards newly bone tissue formation. In particular, scaffold porosity and pore size play a pivotal role in cell migration, adhesion and proliferation, thus increasing cell-material surface interaction and osteogenic signals transmission...
December 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30287027/the-three-dimensional-cues-integrated-biomaterial-potentiates-differentiation-of-human-mesenchymal-stem-cells
#19
Min Hee Park, Ramesh Subbiah, Min Jung Kwon, Woo Jun Kim, Sang Heon Kim, Kwideok Park, Kangwon Lee
Alginate (Alg) hydrogels, the most popular natural biomaterials, mimic the extracellular matrix (ECM) microenvironment and offer potential biomedical applications. Despite their excellent properties such as biocompatibility, hydrophilicity and ionic crosslinking, the absence of an intrinsic cell adhesion domain lessens their cell-carrier applications in tissue engineering. Herein, we suggest a three-dimensional (3D) cell culture system by integrating Alg hydrogel and fibroblast-derived matrix (FDM). FDM including cell-adhesion motifs, signaling, and physico-mechanical cues is prepared by the decellularization process by avoiding unfavorable chemical reactions...
December 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30286981/integrating-3d-printed-phbv-calcium-sulfate-hemihydrate-scaffold-and-chitosan-hydrogel-for-enhanced-osteogenic-property
#20
Xiangling Ye, Lihua Li, Zefeng Lin, Weiliang Yang, Mingyang Duan, Lingling Chen, Yuanjun Xia, Zepeng Chen, Yao Lu, Ying Zhang
We developed the 3D-printed poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/calcium sulfate hemihydrate (PHBV/CaSH) scaffolds by using fused deposition modelling (FDM) technique and then coated the scaffolds with chitosan (CS) acetic acid solution. After drying and neutralization, CS hydrogel was formed on the surface of the scaffolds. The resultant PHBV/CaSH/CS scaffolds could promote the adhesion and proliferation of rat bone marrow stromal cells (rBMSCs) and enhance the osteogenesis of rBMSCs by up-regulating the expression level of osteogenic genes compared to the PHBV and PHBV/CaSH scaffolds...
December 15, 2018: Carbohydrate Polymers
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