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https://www.readbyqxmd.com/read/30121960/determination-of-the-origin-of-oral-squamous-cell-carcinoma-by-microarray-analysis-squamous-epithelium-or-minor-salivary-gland
#1
Makoto Kinouchi, Sayaka Izumi, Koh-Ichi Nakashiro, Yasuo Haruyama, Gen Kobashi, Daisuke Uchida, Tomonori Hasegawa, Hitoshi Kawamata
More than 90% of oral cancers are histopathologically squamous cell carcinomas (SCCs). According to clinical behavior and histopathological features, we hypothesize that oral SCC can originate from either oral squamous epithelium or minor salivary glands. Here, we examined whether some oral SCCs originate from minor salivary glands, and investigated whether these tumors show particularly aggressive biological behavior. The mRNA expression profiles of samples obtained from six patients with oral floor SCC (five men, one woman; mean age, 62...
August 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30121923/comparative-study-of-hif-1%C3%AE-and-hif-2%C3%AE-immunopositive-neurons-and-capillaries-in-rat-cortex-under-conditions-of-tissue-hypoxia
#2
V M Chertok, V A Nevzorova, N V Zakharchuk
We measured the content of HIF-1α and HIF-2α-immunopositive neurons and microvessels in the brain of Wistar rats during the first 24 h of tissue hypoxia induced by subcutaneous injection of cobalt dichloride (50 mg/kg). In control rats (without hypoxia), immunohistochemical marker HIF-2α in cortex of parietal lobe was not detected, and HIF-1α was detected only in few weakly stained pale neurons and capillaries. In 30 min after injection of the cobalt salt, the number of HIF-1α+ neurons increased by 25...
August 18, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/30121915/disturbance-of-the-epithelial-mesenchymal-transition-as-a-cause-of-the-defective-development-of-human-spontaneous-abortions-with-abnormal-karyotype
#3
V I Kukharenko
Genetic program regulating epithelial-mesenchymal transition is activated at the early stages of embryogenesis. Abnormal karyotype of the embryo disrupts the fundamental process of epithelial-mesenchymal transition, which is seen from incomplete morphological rearrangement and reduced migration capacity of cells, as well as low level of expression of epithelial-mesenchymal transition markers (fibronectin, collagen, and glycosaminoglycans). Disturbances of the epithelial-mesenchymal transition affect the proliferative potential of cells with aberrant karyotype, which contributes to the delay of embryonic development and correlates with the formation of abnormal phenotype in carriers of chromosomal abnormalities...
August 18, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/30121911/modulation-of-the-inflammatory-status-of-macrophages-and-their-paracrine-effect-on-the-sensitivity-of-adipocytes-to-insulin-with-sirtuin-and-ppar%C3%AE-receptor-activators
#4
Yu S Stafeev, S S Michurina, E S Zubkova, I B Beloglazova, E I Ratner, E V Parfenova, M Yu Men'shikov
We studied the effect of SIRT1 deacetylase and PPARγ receptor activators on proinflammatory (M1), anti-inflammatory (M2) polarization of RAW264.7 macrophages and their modulating effects on insulin sensitivity of adipocytes. In M1 macrophages, the expression of TNFα and CXCL9, secretion of CXCL11, ROS generation, and content of dendritic-like cells were elevated. In M2 macrophages, expression of IGF-1 and ALOX15 factors was enhanced. SIRT1 activator (DCHC) and PPARγ receptor ligand (rosiglitazone) reduced expression of inflammatory markers TNFα and CXCL9 and increased expression of IGF-1 and ALOX15...
August 18, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/30121847/inflammatory-and-fibrinolytic-system-in-acute-respiratory-distress-syndrome
#5
REVIEW
Mahesh Manjunath Gouda, Sadiya B Shaikh, Yashodhar Prabhakar Bhandary
Acute respiratory distress syndrome (ARDS) is the most advanced form of acute lung injury (ALI). This is characterized by bilateral pulmonary infiltrates and severe hypoxemia. According to Berlin definition of ARDS, this is defined based on the timings, radiographic changes, edema formation, and severity on the PaO2 /FiO2 ratio. During ARDS, the loss of integrity of the epithelium causes the septic shock. The degree of epithelial injury is the major prognostic marker of ARDS. In addition to this, inflammatory cell migration, fibro-proliferation, and activation of apoptosis also play an important role in the pathophysiology of ARDS...
August 18, 2018: Lung
https://www.readbyqxmd.com/read/30121835/metabolites-of-prostaglandin-synthases-as-potential-biomarkers-of-lyme-disease-severity-and-symptom-resolution
#6
REVIEW
Alicia Caroline Jarosz, Alaa Badawi
BACKGROUND: Lyme disease or Lyme borreliosis (LB) is the commonest vector-borne disease in the North America. It is an inflammatory disease caused by the bacterium Borrelia burgdorferi. The role of the inflammatory processes mediated by prostaglandins (PGs), thromboxanes and leukotrienes (LTs) in LB severity and symptoms resolution is yet to be elucidated. OBJECTIVES: We aim to systematically review and evaluate the role of PGs and related lipid mediators in the induction and resolution of inflammation in LB...
August 18, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30121677/a-broad-test-based-on-fluorescent-multiplex-pcr-for-noninvasive-prenatal-diagnosis-of-cystic-fibrosis
#7
Claire Guissart, Frédéric Tran Mau Them, Vanessa Debant, Victoria Viart, Charlotte Dubucs, Victoria Pritchard, Cécile Rouzier, Amandine Boureau-Wirth, Emmanuelle Haquet, Jacques Puechberty, Eric Bieth, Philippe Khau Van Kien, Marie-Pierre Brechard, Caroline Raynal, Anne Girardet, Mireille Claustres, Michel Koenig, Marie-Claire Vincent
BACKGROUND: Analysis of cell-free fetal DNA in maternal plasma is very promising for early diagnosis of monogenic diseases. However, it has been limited by the need to set up patient- or disease-specific custom-made approaches. Here we propose a universal test based on fluorescent multiplex PCR and size fragment analysis for an indirect diagnosis of cystic fibrosis (CF). METHODS: The test, based on haplotyping, includes nine intra- and extragenic short tandem repeats of the CFTR locus, the coamplification of p...
August 17, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/30121666/mir-382-promotes-differentiation-of-rat-liver-progenitor-cell-wb-f344-by-targeting-ezh2
#8
Yongxia Zheng, Jiansheng Zhou, Xuebo Li, Guangtao Xu, Mingliang Jin, Ruilin Shen, Ruibing Su, Shuyu Zhan, Baoyue Ding, Mingguang Jia, Yuzhong Cui, Xiaojun Yu
BACKGROUND/AIMS: Liver progenitor cells (LPCs) were considered as a promising hepatocyte source of cell therapy for liver disease due to their self-renewal and differentiation capacities, while little is known about the mechanism of LPC differentiate into hepatocytes. This study aims to explore the effect of miR-382, a member of Dlk1-Dio3 microRNA cluster, during hepatic differentiation from LPCs. METHODS: In this study, we used rat liver progenitor cell WB-F344 as LPC cell model and HGF as inducer to simulate the process of LPCs hepatic differentiation, then microRNAs were quantified by qPCR...
August 17, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30121651/high-mobility-group-box-1-regulates-uterine-decidualization-through-bone-morphogenetic-protein-2-and-plays-a-role-in-kruppel-like-factor-5-induced-stromal-differentiation
#9
Kai Wang, Zhan-Qing Yang, Hai-Fan Yu, Yu-Si Wang, Bin Guo, Zhan-Peng Yue
BACKGROUND/AIMS: High mobility group box 1 (Hmgb1) is associated with a variety of physiological processes including embryonic development, cell proliferation and differentiation, but little information is available regarding its biological role in decidualization. METHODS: In situ hybridization, real-time PCR, RNA interference, gene overexpression and MTS assay were used to analyze the spatiotemporal expression of Hmgb1 in mouse uterus during the pre-implantation period, and explore its function and regulatory mechanisms during uterine decidualization...
August 17, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30121649/crosstalk-between-nuclear-glucose-regulated-protein-78-and-tumor-protein-53-contributes-to-the-lipopolysaccharide-aggravated-apoptosis-of-endoplasmic-reticulum-stress-responsive-porcine-intestinal-epithelial-cells
#10
Qian Jiang, Gang Liu, Jiashun Chen, Kang Yao, Yulong Yin
BACKGROUND/AIMS: Lipopolysaccharides (LPSs) act as virulence factors that trigger intestinal inflammation and thereby compromise the production of pigs worldwide. Intestinal diseases and dysfunction have been attributed to endoplasmic reticulum stress (ERS) and the subsequent apoptosis of intestinal epithelial cells. Therefore It is important to explore whether LPSs aggravate ERS-mediated apoptosis of intestinal epithelial cells. METHODS: ERS and inflammation models were established in porcine cell line J2 (IPEC-J2) and the cells were treated with tunicamycin or LPS at specific times...
August 17, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30121624/ddr1-regulates-thyroid-cancer-cell-differentiation-via-igf-2-ir-a-autocrine-signaling-loop
#11
Veronica Vella, Maria Luisa Nicolosi, Patrizia Cantafio, Michele Massimino, Rosamaria Lappano, Paolo Vigneri, Roberto Ciuni, Pietro Gangemi, Andrea Morrione, Roberta Malaguarnera, Antonino Belfiore
Patients with thyroid cancers refractory to radioiodine (RAI) treatment show a limited response to various therapeutic options and a low survival rate. The recent use of multikinase inhibitors has also met limited success. An alternative approach relies on drugs that induce cell differentiation, as the ensuing increased expression of the cotransporter for sodium and iodine (NIS) may partially restore sensitivity to radioiodine. The inhibition of the ERK1/2 pathway has shown some efficacy in this context. Aggressive thyroid tumors overexpress the isoform A of the insulin receptor (IR-A) and its ligand IGF-2; this IGF-2/IR-A loop is associated with de-differentiation and stem-like phenotype, resembling RAI refractory tumors...
August 18, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/30121621/molecular-basis-of-distinct-oestrogen-responses-in-endometrial-and-breast-cancer
#12
Eva Baxter, Karolina Windloch, Greg Kelly, Jason S Lee, Frank Gannon, Donal Brennan
Up to 80% of endometrial and breast cancers express oestrogen receptor alpha (ERα). Unlike breast cancer, anti-oestrogen therapy has had limited success in endometrial cancer, raising the possibility that oestrogen has different effects in both cancers. We investigated the role of oestrogen in endometrial and breast cancers using data from The Cancer Genome Atlas (TCGA) in conjunction with cell line studies. Using phosphorylation of ERα (ERα-pSer118) as a marker of transcriptional activation of ERα in TCGA datasets, we found that genes associated with ERα-pSer118 were predominantly unique between tumour types and have distinct regulators...
August 18, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/30121527/the-effects-of-elevated-fibroblast-growth-factor-23-on-mandibular-growth-in-rats
#13
Yanan Wu, Jinkai Zhang, Fengshan Chen
OBJECTIVE: The aim of this study is to elucidate the local effects of fibroblast growth factor 23 (FGF23) in on mandibular condylar growth in growing rats. DESIGN: Growing Sprague-Dawley rats received intra-temporomandibular joint injections of phosphate buffer solution (PBS), adenovirus-mediated green fluorescent protein (Ad-GFP) or adenovirus-mediated fibroblast growth factor 23 (Ad-FGF23), which were marked as groups A, B, and C, respectively. In vitro, we treated rat mandibular cartilage chondrocytes with PBS, Ad-GFP, and Ad-FGF23...
August 1, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/30121441/where-there-is-no-brain-imaging-safety-and-diagnostic-value-of-lumbar-puncture-in-patients-with-neurological-disorders-in-a-rural-hospital-of-central-africa
#14
Deby Mukendi, Jean-Roger Lilo Kalo, Tharcisse Kayembe, Pascal Lutumba, Barbara Barbé, Philippe Gillet, Jan Jacobs, Cedric P Yansouni, François Chappuis, Kristien Verdonck, Marleen Boelaert, Andrea S Winkler, Emmanuel Bottieau
Analysis of cerebrospinal fluid (CSF) obtained by lumbar puncture (LP) is an essential step for the diagnostic approach of neurological disorders, in particular neuro-infections. In low-resource settings, it is even often the only available diagnostic method. Despite its key contribution, little is known on the risks and benefits of LP in the large tropical areas where hospital-based neuroimaging is not available. The objectives of this study were to assess the safety and diagnostic yield of LP in a rural hospital of central Africa and to identify predictors of CSF pleocytosis (white blood cell count >5/μL) as surrogate marker of neuro-infections...
August 9, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30121370/high-proliferation-rate-and-tnm-stage-but-not-histomorphological-subtype-are-independent-prognostic-markers-for-overall-survival-in-papillary-renal-cell-carcinoma
#15
Iris Polifka, Abbas Agaimy, Edwin Herrmann, Verena Spath, Lutz Trojan, Michael Stöckle, Frank Becker, Philipp Ströbel, Christian Wülfing, Andres J Schrader, Peter Barth, Michael Staehler, Christian Stief, Markus Hohenfellner, Stephan Macher-Göppinger, Heinz Höfler, Bernd Wullich, Joachim Noldus, Walburgis Brenner, Frederik C Roos, Bernhard Walter, Wolfgang Otto, Maximilian Burger, Axel Haferkamp, Carol I Geppert, Christine Stöhr, Arndt Hartmann
Papillary renal cell carcinoma (PRCC) is currently divided in two subtypes. We reviewed a large cohort of PRCC and correlated subtype, morphological features and diagnostic marker expression with overall survival (OS) to uncover differences between the two subtypes. 376 renal tumors initially diagnosed as PRCC with clinical and survival data were collected from the participating centers. 246 tumors were classified as PRCC1 (65.4%) and 130 as PRCC2 (34.6%) and graded according to the 2016 World Health Organization/International Society of Urological Pathology grading system...
August 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/30121319/senescence-and-senotherapeutics-a-new-field-in-cancer-therapy
#16
REVIEW
Vassilios Myrianthopoulos, Konstantinos Evangelou, Panagiotis V S Vasileiou, Tomer Cooks, Theodoros P Vassilakopoulos, Gerassimos A Pangalis, Myrsini Kouloukoussa, Christos Kittas, Alexandros G Georgakilas, Vassilis G Gorgoulis
Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal activation during embryonic development or normal adult life is linked with beneficial properties. In contrast, persistent (chronic) senescence seems to exert detrimental effects fostering aging and age-related disorders, such as cancer. Due to the lack of a reliable marker able to detect senescence in vivo, its precise impact in age-related diseases is to a large extent still undetermined. A novel reagent termed GL13 (SenTraGorTM ) that we developed, allowing senescence recognition in any type of biological material, emerges as a powerful tool to study the phenomenon of senescence in vivo...
August 16, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/30121256/dna-methylation-and-the-yap-wwtr1-pathway-prevent-pathological-remodeling-during-bladder-obstruction-by-limiting-expression-of-bdnf
#17
Martin Sidler, Karen J Aitken, Jia-Xin Jiang, Chris Sotiropoulos, Prateek Aggarwal, Arsalan Anees, Cynthia Chong, Aliza Siebenaller, Thenuka Thanabalasingam, J Maxwell White, Sanaa Choufani, Rosanna Weksberg, Bruno Sangiorgi, Jeff Wrana, Paul Delgado-Olguin, Darius J Bägli
Chronic bladder obstruction and bladder smooth muscle cell (BSMC) stretch provide fibrotic and mechanical environments that can induce epigenetic change. Therefore, we examined the role of DNA methylation in bladder pathology and transcriptional control. Sprague-Dawley female rats underwent partial bladder obstruction by ligation of a silk suture around the proximal urethra next to a 0.9 mm steel rod. Sham operation comprised passing the suture around the urethra. After two weeks, rats were randomized to normal saline or DNA methyltransferase inhibitor, 5-aza-2-deoxycytidine (DAC) at 1 mg/kg, 3 times/week intraperitoneally...
August 16, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/30121132/histotype-classification-of-ovarian-carcinoma-a-comparison-of-approaches
#18
Lauren C Peres, Kara L Cushing-Haugen, Michael Anglesio, Kristine Wicklund, Rex Bentley, Andrew Berchuck, Linda E Kelemen, Tayyebeh M Nazeran, C Blake Gilks, Holly R Harris, David G Huntsman, Joellen M Schildkraut, Mary Anne Rossing, Martin Köbel, Jennifer A Doherty
OBJECTIVE: Major changes in the classification of ovarian carcinoma histotypes occurred over the last two decades, resulting in the current 2014 World Health Organization (WHO) diagnostic criteria that recognize five principal histotypes: high-grade serous, low-grade serous, endometrioid, clear cell, and mucinous carcinoma. We assessed the impact of these guidelines and use of immunohistochemical (IHC) markers on classification of ovarian carcinomas in existing population-based studies...
August 15, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30121075/characterization-of-stem-cell-and-cancer-stem-cell-populations-in-ovary-and-ovarian-tumors
#19
Seema C Parte, Surinder K Batra, Sham S Kakar
BACKGROUND: Ovarian cancer is a complicated malady associated with cancer stem cells (CSCs) contributing to 238,700 estimated new cases and 151,900 deaths per year, worldwide. CSCs comprise a tiny fraction of tumor-bulk responsible for cancer recurrence and eventual mortality. CSCs or tumor initiating cells are responsible for self-renewal, differentiation and proliferative potential, tumor initiation capability, its progression, drug resistance and metastatic spread. Although several biomarkers are implicated in these processes, their distribution within the ovary and association with single cell type has neither been established nor demonstrated across ovarian tumor developmental stages...
August 18, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/30120989/tgf-%C3%AE-1-induced-smad2-3-4-activation-promotes-relm-%C3%AE-transcription-to-modulate-the-endothelium-mesenchymal-transition-in-human-endothelial-cells
#20
Yongliang Jiang, Xuanfen Zhou, Ruicheng Hu, Aiguo Dai
Endothelial-to-mesenchymal transition (EndMT), which is characterized by increased proliferation, migration and invasion of endothelial cells, increased expression of mesenchymal markers and reduced expression of endothelial markers, has been reported to be closely related to the pathogenesis of several diseases, including pulmonary fibrosis. Resistin-like molecule-β (RELM-β), also known as "found in inflammatory zone 2" (FIIZ2), plays an essential role in airway remodeling and pulmonary fibrosis; however, its role and mechanism in EndMT remain unclear...
August 15, 2018: International Journal of Biochemistry & Cell Biology
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