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Bcl6 AND Langerhans cells

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https://www.readbyqxmd.com/read/21511186/a-subset-of-interleukin-21-chemokine-receptor-ccr9-t-helper-cells-target-accessory-organs-of-the-digestive-system-in-autoimmunity
#1
Helen M McGuire, Alexis Vogelzang, Cindy S Ma, William E Hughes, Pablo A Silveira, Stuart G Tangye, Daniel Christ, David Fulcher, Marika Falcone, Cecile King
This study describes a CD4+ T helper (Th) cell subset marked by coexpression of the cytokine interleukin 21 (IL-21) and the gut-homing chemokine receptor CCR9. Although CCR9+ Th cells were observed in healthy mice and humans, they were enriched in the inflamed pancreas and salivary glands of NOD mice and in the circulation of Sjögren's syndrome patients. CCR9+ Th cells expressed large amounts of IL-21, inducible T cell costimulator (ICOS), and the transcription factors Bcl6 and Maf, and also supported antibody production from B cells, thereby resembling T follicular B helper (Tfh) cells...
April 22, 2011: Immunity
https://www.readbyqxmd.com/read/20935202/bcl6-is-required-for-differentiation-of-ig-like-transcript-3-fc-induced-cd8-t-suppressor-cells
#2
Chih-Chao Chang, George Vlad, Vivette D D'Agati, Zhuoru Liu, Qing-yin Zhang, Piotr Witkowski, Ali A Torkamani, Michael B Stokes, Eric K Ho, Raffaello Cortesini, Nicole Suciu-Foca
Ig-like transcript 3 (ILT3) is an inhibitory receptor expressed by tolerogenic dendritic cells. When human CD8(+) T cells are allostimulated in the presence of recombinant ILT3-Fc protein, they differentiate into antigenic specific T suppressor (Ts) cells that inhibit CD4 and CD8 T cell effector function both in vitro and in vivo. ILT3-Fc-induced CD8(+) Ts cells express high amounts of BCL6 that are crucial to their function. Knockdown of BCL6 from unprimed human T cells prevents their differentiation into Ts cells, whereas ex vivo overexpression of BCL6 converts CD8(+) T cells into Ts cells...
November 15, 2010: Journal of Immunology: Official Journal of the American Association of Immunologists
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