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Korawan E Sirisomboonwong, Joanne Martindale, Martin Keefe, David Goudie, Gemma Poke
Multiple self-healing squamous epithelioma (MSSE, Ferguson-Smith disease) and Loeys-Dietz syndrome (LDS) are allelic conditions associated with pathogenic variants in the transforming growth factor beta receptor 1 gene (TGFBR1). We describe a patient with a novel missense variant in this gene: c.664G > A, p.[Gly222Arg], who clinically presents with both syndromes. The patient also has a history of gastric antral vascular ectasia, which has not been reported previously in LDS.
December 4, 2018: American Journal of Medical Genetics. Part A
Shipeng Chen, Nanxiang Zhang, Baohao Zhang, Bao Zhang, Jian Song
Self-healing ionogel is a promising smart material because of its high conductivity and reliable stimuli responsiveness upon mechanical damage. However, self-healing ionogels possessing rapid, complete recovery properties and multi-functionality are still limited. Herein, we designed a new D-gluconic acetal-based gelator (PB8) bearing a urea group in the alkyl side chain. Interestingly, the balance between hydrophilicity and hydrophobicity of the molecule is achieved. Thus, PB8 could form transparent ionogels because of its excellent affinity to ionic liquids (ILs), which exhibited appropriate mechanical strength, high viscoelasticity, and efficient self-healing properties...
December 4, 2018: ACS Applied Materials & Interfaces
Jiaofang Huang, Suying Liu, Chen Zhang, Xinyu Wang, Jiahua Pu, Fang Ba, Shuai Xue, Haifeng Ye, Tianxin Zhao, Ke Li, Yanyi Wang, Jicong Zhang, Lihua Wang, Chunhai Fan, Timothy K Lu, Chao Zhong
Bacterial biofilms can be programmed to produce living materials with self-healing and evolvable functionalities. However, the wider use of artificial biofilms has been hindered by limitations on processability and functional protein secretion capacity. We describe a highly flexible and tunable living functional materials platform based on the TasA amyloid machinery of the bacterium Bacillus subtilis. We demonstrate that genetically programmable TasA fusion proteins harboring diverse functional proteins or domains can be secreted and can assemble into diverse extracellular nano-architectures with tunable physicochemical properties...
December 3, 2018: Nature Chemical Biology
Shota Imai, Mikihito Takenaka, Mitsuo Sawamoto, Takaya Terashima
Amphiphilic random copolymers bearing hydrophilic poly(ethylene glycol) (PEG) and hydrophobic alkyl pendants showed dynamic self-sorting behavior, i.e., self-recognition, under competitive conditions in aqueous media. The self-sorting universally takes place not only in water but also in hydrogels and on the material surfaces, according to encoded information originating from the primary structure of composition and pendants. Binary blends of the copolymers with different composition and/or alkyl pendants readily induced com-position and/or alkyl pendant-dependent self-sorting to simultaneously provide discrete and size-controlled micelles with hydrophobic cores...
December 3, 2018: Journal of the American Chemical Society
Jochem H Smit, Jasper H M van der Velde, Jingyi Huang, Vanessa Trauschke, Sarah S Henrikus, Si Chen, Nikolaos Eleftheriadis, Eliza M Warszawik, Andreas Herrmann, Thorben Cordes
While buffer cocktails remain the most commonly used method for photostabilization and photoswitching of fluorescent markers, intramolecular triplet-state quenchers emerge as an alternative strategy to impart fluorophores with 'self-healing' or even functional properties such as photoswitching. In this contribution, we evaluated combinations of both approaches and show that inter- and intramolecular triplet-state quenching processes compete with each other. We find that although the rate of triplet-state quenching is additive, the photostability is limited by the faster pathway...
November 30, 2018: Physical Chemistry Chemical Physics: PCCP
Shuang Yang, Zeyuan Xu, Sha Xue, Praneeth Kandlakunta, Lei Cao, Jinsong Huang
Organohalide metal perovskites have emerged as promising semiconductor materials for use as space solar cells and radiation detectors. However, there is a lack of study of their stability under operational conditions. Here a stability study of perovskite solar cells under gamma-rays and visible light simultaneously is reported. The perovskite active layers are shown to retain 96.8% of their initial power conversion efficiency under continuous irradiation of gamma-rays and light for 1535 h, where gamma-rays have an accumulated dose of 2...
November 28, 2018: Advanced Materials
Lindsay Riley, Lucas Schirmer, Tatiana Segura
Granular hydrogels are emerging as a versatile and effective platform for tissue engineered constructs in regenerative medicine. The hydrogel microparticles (HMPs) that compose these materials exhibit particle jamming above a minimum packing fraction, which results in a bulk, yet dynamic, granular hydrogel scaffold. These injectable, microporous scaffolds possess self-assembling, shear-thinning, and self-healing properties. Recently, they have been utilized as cell cultures platforms and extracellular matrix mimics with remarkable success in promoting cellular infiltration and subsequent tissue remodeling in vivo...
November 24, 2018: Current Opinion in Biotechnology
Yingjie Wang, Wei Zhu, Ke Xiao, Zeng Li, Qi Ma, Weifeng Li, Songpo Shen, Xisheng Weng
BACKGROUND: HA modified by bisphosphonate (BP) (HA-BP) was synthesized by chemical reaction and possessed promising properties such as self-healing, injection ability, and strong adhesion. The main aim of this study was to confirm its role in promoting osteogenic differentiation in vitro and bone regeneration in vivo. METHODS: The cell biocompatibility of this material was determined using the CCK-8 assay. Alkaline phosphatase (ALP), osteocalcin (OT), vascular endothelial growth factor (VEGF), and collagen I were assessed by quantitative real-time polymerase chain reaction (Q-PCR) in the treated group...
November 20, 2018: Biochemical and Biophysical Research Communications
Isaac Nape, Eileen Otte, Adam Vallés, Carmelo Rosales-Guzmán, Filippo Cardano, Cornelia Denz, Andrew Forbes
Using spatial modes for quantum key distribution (QKD) has become highly topical due to their infinite dimensionality, promising high information capacity per photon. However, spatial distortions reduce the feasible secret key rates and compromise the security of a quantum channel. In an extreme form such a distortion might be a physical obstacle, impeding line-of-sight for free-space channels. Here, by controlling the radial degree of freedom of a photon's spatial mode, we are able to demonstrate hybrid high-dimensional QKD through obstacles with self-reconstructing single photons...
October 15, 2018: Optics Express
Tiago B Becher, Carolyne B Braga, Diego L Bertuzzi, Miguel D Ramos, Ayaz Hassan, Frank N Crespilho, Catia Ornelas
Rheology, small-angle X-ray scattering (SAXS), and dynamic light scattering (DLS) analysis, zeta potential measurement, scanning electron microscopy (SEM), and micro-FTIR and absorbance spectroscopy were used to enlighten the controversial literature about LAPONITE® materials. Our data suggest that pristine LAPONITE® in water does not form hydrogels induced by the so-called "house of cards" assembly, but rather forms Wigner glasses governed by repulsive forces. Ionic interactions between anisotropic LAPONITE® nanodiscs, sodium polyacrylate and inorganic salts afforded hydrogels that were transparent, self-standing, moldable, strong, and biocompatible with shear-thinning and self-healing behavior...
November 22, 2018: Soft Matter
Marcos Fernández-Castaño Romera, Xianwen Lou, Jurgen Schill, Gijs M Ter Huurne, Peter-Paul K H Fransen, Ilja K Voets, Cornelis Storm, Rint P Sijbesma
The cytoskeleton is a highly adaptive network of filamentous proteins capable of stiffening under stress even as it dy-namically assembles and disassembles with time constants of minutes. Synthetic materials that combine reversibility and strain-stiffening properties remain elusive. Here, strain-stiffening hydrogels that have dynamic fibrous polymers as their main structural components are reported. The fibers form via self-assembly of bolaamphiphiles (BA) in water and have a well-defined cross-section of 9 to 10 molecules...
November 22, 2018: Journal of the American Chemical Society
Jun-Ling Wu, Tong Li, Xu Gao, Qiang Zhang, Di Liu, Jian-Hua Ge, Chuan-Jian Zhou
OBJECTIVE: This investigation aimed to develop a novel self-healing and antibacterial dental resin composite. The effects of water immersion on its properties were also evaluated. METHODS: Microcapsules filled with healing agent of triethylene glycol dimethacrylate were synthesized on the basis of previous studies. Antibacterial resin composite contained nano-antibacterial inorganic fillers that were modified by quaternary ammonium salt with long-chain alkyl. Microcapsules were incorporated into antibacterial resin composite at mass fraction of 7...
October 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
Jingjing Hu, Zhao Zheng, Cenxi Liu, Qianyu Hu, Xiaopan Cai, Jianru Xiao, Yiyun Cheng
Aminoglycosides are a family of antibiotics with a wide-spread antibacterial spectrum and high antibacterial activity. However, they are less effective against anaerobic pathogens due to the requirement of aerobic respiration to exert their antibacterial functions. Here, we prepared a pH-responsive hydrogel with potent antibacterial activities against both aerobic and anaerobic pathogens. The hydrogel was prepared by reacting oxidized dextran with aminoglycoside and an ornidazole analogue via an acid-labile Schiff base linkage...
November 21, 2018: Biomaterials Science
Donghee Son, Zhenan Bao
Skin-inspired wearable electronic/biomedical systems based on functional nanomaterials with exceptional electrical and mechanical properties have revolutionized wearable applications, such as portable Internet of Things, personalized healthcare monitors, human-machine interfaces, and even always-connected precise medicine systems. Despite these advancements, including the ability to predict and to control nanolevel phenomena of functional nanomaterials precisely and strategies for integrating nanomaterials onto desired substrates without performance losses, skin-inspired electronic nanosystems are not yet feasible beyond proof-of-concept devices...
November 21, 2018: ACS Nano
Bo Wang, Jing Liu, Chen Jia Wang, Xin Zhang, Jia Wei Liu, Qiang Li, Qiang Zhang
To clarify the sustainable soil reinforcement capacity of the lateral root branches of shrubs after injury by fracture force in a semi-arid coal mining subsidence region of Shendong, we analyzed the ultimate anti-fracture mechanical characteristics of three shrub species, Caragana microphylla, Salix cheilophila, and Hippophae rhamnoides, as well as the self-healing ability of their growth indices and mechanical characteristics after injury by fracture force. The results showed that the anti-fracture force and its strength had significant difference among the three shrub species in their late-ral root branches in the early stage of growing season, with the order of C...
November 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Wenda Wang, Ravin Narain, Hongbo Zeng
Hydrogels are three-dimensional cross-linked polymer networks which can absorb and retain large amount of water. As representative soft materials with tunable chemical, physical and biological properties, hydrogels with different functions have been developed and utilized in a broad range of applications, from tissue engineering to soft robotics. However, conventional hydrogels usually suffer from weak mechanical properties and they are easily deformed or damaged when they are subjected to mechanical forces...
2018: Frontiers in Chemistry
Wang Zhou, Xi Chen, Guolin Zhao, Dengqiu Xu, Zhenzhou Jiang, Luyong Zhang, Tao Wang
Psoralen is a major component of the common traditional Chinese medicine Fructus Psoraleae (FP). In this study, we focused on psoralen to explore FP-induced hepatotoxicity and the underlying mechanisms. The acute oral median lethal dose of psoralen in ICR mice was determined to be 1,673 mg/kg. C57BL/6 mice were administered psoralen intragastrically at doses of 400 mg/kg or 800 mg/kg, and were sacrificed 24 h after treatment. Changes in various hepatotoxicity indicators demonstrated that psoralen can cause mild liver injury in mice...
2018: Frontiers in Pharmacology
Jiarong Huang, Liming Cao, Daosheng Yuan, Yukun Chen
We designed novel self-healing thermoplastic vulcanizates (TPVs), achieving excellent thermal/magnetic/light triggered shape memory assisted self-healing behavior. Damage on polylactide (PLA)/epoxidized natural rubber (ENR)/Fe3O4 TPVs could be healed via three events synergistically: The shape memory effect of TPVs resulted in the physical contact of damaged surfaces; the desorption-absorption of ENR/Fe3O4 bound rubber promoted inter-diffusion of ENR chains, leading to the self-healing of ENR phase; ENR was grafted onto PLA segment to assist PLA rearranging and entangling again to achieve the repair of TPVs...
November 20, 2018: ACS Applied Materials & Interfaces
X X Zhang, J Wang, Y Xiao, L J Ma
Objective: To observe the clinical course of children with juvenile-onset recurrent respiratory papillomatosis (JORRP) until 14 years old. Methods: The clinical data of one hundred and twenty cases treated between Januray 1, 2002 and September 30, 2017 in Beijing Tongren Hospital were analyzed retrospectively. Excluding the deaths and the lost, patients who could be ≥ 5 years without recurrence, were defined as the cured group, and < 5 years with recurrence defined as the recurrent group. Furthermore, using statistical methods to analyze the differences of the age of initial operation, total number of operations, invasive lesion, HPV infection, tracheotomy, airway dissemination after tracheotomy and time of tube wear between the two groups...
November 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Raluca Ioana Baron, Maria Bercea, Mihaela Avadanei, Gabriela Lisa, Gabriela Biliuta, Sergiu Coseri
A new approach for the preparation of poly (vinyl alcohol) (PVA) - cellulose based composite hydrogels by freezing/thawing method was conceived. We synthesized firstly the tricarboxy cellulose (OxC) (bearing three carboxyl groups in one anhydroglucose unit) using a one shot oxidation procedure and subsequently, the aqueous solutions of OxC were mixed with PVA solutions in different ratios, in the absence of any supplementary cross-linking agent. The spectral methods, FTIR, 1 H, 13 C NMR, as well as rheology measurements were used to assess the degree of interaction between the two components...
November 17, 2018: International Journal of Biological Macromolecules
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