keyword
https://read.qxmd.com/read/38423263/a-novel-restrainer-device-for-acquistion-of-brain-images-in-awake-rats
#1
JOURNAL ARTICLE
Jakov Tiefenbach, Logan Shannon, Mark Lobosky, Sadie Johnson, Hugh H Chan, Nicole Byram, Andre G Machado, Charlie Androjna, Kenneth B Baker
Functional neuroimaging methods like fMRI and PET are vital in neuroscience research, but require that subjects remain still throughout the scan. In animal research, anesthetic agents are typically applied to facilitate the acquisition of high-quality data with minimal motion artifact. However, anesthesia can have profound effects on brain metabolism, selectively altering dynamic neural networks and confounding the acquired data. To overcome the challenge, we have developed a novel head fixation device designed to support awake rat brain imaging...
February 27, 2024: NeuroImage
https://read.qxmd.com/read/38419667/study-protocol-cerebral-characterization-of-sensory-gating-in-disconnected-dreaming-states-during-propofol-anesthesia-using-fmri
#2
JOURNAL ARTICLE
Benedetta Cecconi, Javier Montupil, Sepehr Mortaheb, Rajanikant Panda, Robert D Sanders, Christophe Phillips, Naji Alnagger, Emma Remacle, Aline Defresne, Melanie Boly, Mohamed Ali Bahri, Laurent Lamalle, Steven Laureys, Olivia Gosseries, Vincent Bonhomme, Jitka Annen
BACKGROUND: Disconnected consciousness describes a state in which subjective experience (i.e., consciousness) becomes isolated from the external world. It appears frequently during sleep or sedation, when subjective experiences remain vivid but are unaffected by external stimuli. Traditional methods of differentiating connected and disconnected consciousness, such as relying on behavioral responsiveness or on post-anesthesia reports, have demonstrated limited accuracy: unresponsiveness has been shown to not necessarily equate to unconsciousness and amnesic effects of anesthesia and sleep can impair explicit recollection of events occurred during sleep/sedation...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38378942/longitudinal-monitoring-of-the-mouse-brain-reveals-heterogenous-network-trajectories-during-aging
#3
JOURNAL ARTICLE
Özgün Özalay, Tomas Mediavilla, Bruno Lima Giacobbo, Robin Pedersen, Daniel Marcellino, Greger Orädd, Anna Rieckmann, Fahad Sultan
The human aging brain is characterized by changes in network efficiency that are currently best captured through longitudinal resting-state functional MRI (rs-fMRI). These studies however are challenging due to the long human lifespan. Here we show that the mouse animal model with a much shorter lifespan allows us to follow the functional network organization over most of the animal's adult lifetime. We used a longitudinal study of the functional connectivity of different brain regions with rs-fMRI under anesthesia...
February 20, 2024: Communications Biology
https://read.qxmd.com/read/38376600/arthroscopic-reduction-and-rigid-fixation-of-the-anteriorly-displaced-temporomandibular-joint-disc-without-reduction-using-titanium-screw-a-case-series
#4
JOURNAL ARTICLE
Yao Liu, Peng Wang, Wael Telha, Nan Jiang, Ruiye Bi, Songsong Zhu
OBJECTIVES: To evaluate the effectiveness of arthroscopic reduction and rigid fixation (ARRF) using a suture-free titanium screw as a treatment approach to temporomandibular joint's (TMJ) anterior disc displacement without reduction (ADDwoR) and assess its impact on clinical outcomes, including improvements in symptoms related to TMJ disorders. MATERIALS AND METHODS: A series of twenty patients presented to the Department of Orthognathic and Temporomandibular Surgery at West China Hospital of Stomatology between September 2022 and January 2023, complaining of symptoms such as pain, clicking, and limited mouth opening...
February 20, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38346111/mri-based-prostate-cancer-classification-using-3d-efficient-capsule-network
#5
JOURNAL ARTICLE
Yuheng Li, Jacob Wynne, Jing Wang, Justin Roper, Chih-Wei Chang, Ashish B Patel, Joseph Shelton, Tian Liu, Hui Mao, Xiaofeng Yang
BACKGROUND: Prostate cancer (PCa) is the most common cancer in men and the second leading cause of male cancer-related death. Gleason score (GS) is the primary driver of PCa risk-stratification and medical decision-making, but can only be assessed at present via biopsy under anesthesia. Magnetic resonance imaging (MRI) is a promising non-invasive method to further characterize PCa, providing additional anatomical and functional information. Meanwhile, the diagnostic power of MRI is limited by qualitative or, at best, semi-quantitative interpretation criteria, leading to inter-reader variability...
February 12, 2024: Medical Physics
https://read.qxmd.com/read/38328136/propofol-disrupts-the-functional-core-matrix-architecture-of-the-thalamus-in-humans
#6
Zirui Huang, George A Mashour, Anthony G Hudetz
Research into the role of thalamocortical circuits in anesthesia-induced unconsciousness is difficult due to anatomical and functional complexity. Prior neuroimaging studies have examined either the thalamus as a whole or focused on specific subregions, overlooking the distinct neuronal subtypes like core and matrix cells. We conducted a study of heathy volunteers and functional magnetic resonance imaging during conscious baseline, deep sedation, and recovery. We advanced the functional gradient mapping technique to delineate the functional geometry of thalamocortical circuits, within a framework of the unimodal-transmodal functional axis of the cortex...
January 24, 2024: bioRxiv
https://read.qxmd.com/read/38317484/basics-for-pediatric-brain-tumor-imaging-techniques-and-protocol-recommendations
#7
REVIEW
Ah Young Jung
This review provides an overview of the current state of pediatric brain tumor imaging, emphasizing the role of various imaging sequences and highlighting the advantages of standardizing protocols for pediatric brain tumor imaging in diagnosis and treatment response evaluation. Basic anatomical sequences such as pre- and post-contrast 3D T1-weighted, T2-weighted, fluid-attenuated inversion recovery, T2*-weighted, and diffusion-weighted imaging (DWI), are fundamental for assessing tumor location, extent, and characteristics...
January 2024: Brain Tumor Research and Treatment
https://read.qxmd.com/read/38310577/targeted-local-anesthesia-a-novel-slow-release-fe-3-o-4-lidocaine-plga-microsphere-endowed-with-a-magnetic-targeting-function
#8
JOURNAL ARTICLE
Ling-Xi Zheng, Qian Yu, Qiang Li, Chuan-Dong Zheng
PURPOSE: Lidocaine microspheres can prolong the analgesic time to 24-48 h, which still cannot meet the need of postoperative analgesia lasting more than 3 days. Therefore, we added Fe3 O4 to the lidocaine microspheres and used an applied magnetic field to attract Fe3 O4 to fix the microspheres around the target nerves, reducing the diffusion of magnetic lidocaine microspheres to the surrounding tissues and prolonging the analgesic time. METHODS: Fe3 O4 -lidocaine-PLGA microspheres were prepared by the complex-emulsion volatilization method to characterize and study the release properties in vitro...
February 4, 2024: Journal of Anesthesia
https://read.qxmd.com/read/38289856/changes-in-intrinsic-connectivity-networks-topology-across-levels-of-dexmedetomidine-induced-alteration-of-consciousness
#9
JOURNAL ARTICLE
Cecile Staquet, Audrey Vanhaudenhuyse, Sivayini Kandeepan, Robert D Sanders, Demetrius Ribeiro de Paula, Jean François Brichant, Steven Laureys, Vincent Bonhomme, Andrea Soddu
BACKGROUND: Human consciousness is generally thought to emerge from the activity of intrinsic connectivity networks (resting-state networks [RSNs]) of the brain, which have topological characteristics including, among others, graph strength and efficiency. So far, most functional brain imaging studies in anesthetized subjects have compared wakefulness and unresponsiveness, a state considered as corresponding to unconsciousness. Sedation and general anesthesia not only produce unconsciousness but also phenomenological states of preserved mental content and perception of the environment (connected consciousness), and preserved mental content but no perception of the environment (disconnected consciousness)...
January 30, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38196730/a-rare-event-of-perioperative-spinal-subarachnoid-hemorrhage-in-mixed-connective-tissue-disease-a-case-report
#10
Stefano Andreoli, Francesca Porta, Adrian Wäckerlin
BACKGROUND: Spinal subarachnoid hemorrhage (SSH) is an extremely rare event and its causes include trauma, vascular malformation, anticoagulant therapy, and autoimmune disease. Although connective disorders are associated with an increased risk of cerebral subarachnoid hemorrhage (SAH), to our knowledge, the occurrence of SSH associated with mixed connective tissue disease (MCTD) have not been addressed in the literature. We report the unique occurrence of SSH in a patient with anti-U1 ribonucleoprotein (U1-RNP) and anti-nuclear antibodies (ANA) positive MCTD triggered by abdominal surgery...
December 25, 2023: Journal of Spine Surgery (Hong Kong)
https://read.qxmd.com/read/38169536/cerebellar-purkinje-cell-firing-promotes-conscious-recovery-from-anesthesia-state-through-coordinating-neuronal-communications-with-motor-cortex
#11
JOURNAL ARTICLE
Jinpiao Zhu, Chang Chen, Xiaodong Liu, Mengying He, Yuanyuan Fang, Li Wang, Junke Jia, Juan Guo, Ziyue Zhao, Chenyi Gao, Jingang He, Chengshi Xu, Fuqiang Xu, Daqing Ma, Jie Wang, Zongze Zhang
Background: The neurobiological basis of gaining consciousness from unconscious state induced by anesthetics remains unknown. This study was designed to investigate the involvement of the cerebello-thalamus-motor cortical loop mediating consciousness transitions from the loss of consciousness (LOC) induced by an inhalational anesthetic sevoflurane in mice. Methods: The neural tracing and fMRI together with opto - chemogenetic manipulation were used to investigate the potential link among cerebello-thalamus-motor cortical brain regions...
2024: Theranostics
https://read.qxmd.com/read/38166574/major-pneumothorax-during-pediatric-cardiac-mri-procedure-under-general-anesthesia-step-by-step-analysis-and-importance-of-a-well-known-environment-and-material
#12
JOURNAL ARTICLE
Quentin Delhez, Laurent Bairy, John Mitchell, Adrien Maseri
BACKGROUND: To perform step-by-step analysis of the different factors (material, anesthesia technique, human, and location) that led to major pneumothorax during an infrequent pediatric cardiac MRI and to prevent its occurrence in the future. Anesthesia equipment used in a remote location is often different than those in operating rooms. For magnetic resonance imaging (MRI), ventilation devices and monitors must be compatible with the magnetic fields. During cardiac MRI numerous apneas are required and, visual contact with the patient is limited for clinical evaluation...
January 2, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38159279/the-neural-correlates-of-arousal-ventral-posterolateral-nucleus-global-transient-co-activation
#13
JOURNAL ARTICLE
Junrong Han, Qiuyou Xie, Xuehai Wu, Zirui Huang, Sean Tanabe, Stuart Fogel, Anthony G Hudetz, Hang Wu, Georg Northoff, Ying Mao, Sheng He, Pengmin Qin
Arousal and awareness are two components of consciousness whose neural mechanisms remain unclear. Spontaneous peaks of global (brain-wide) blood-oxygenation-level-dependent (BOLD) signal have been found to be sensitive to changes in arousal. By contrasting BOLD signals at different arousal levels, we find decreased activation of the ventral posterolateral nucleus (VPL) during transient peaks in the global signal in low arousal and awareness states (non-rapid eye movement sleep and anesthesia) compared to wakefulness and in eyes-closed compared to eyes-open conditions in healthy awake individuals...
December 29, 2023: Cell Reports
https://read.qxmd.com/read/38116461/altered-dynamical-integration-segregation-balance-during-anesthesia-induced-loss-of-consciousness
#14
JOURNAL ARTICLE
Louis-David Lord, Timoteo Carletti, Henrique Fernandes, Federico E Turkheimer, Paul Expert
In recent years, brain imaging studies have begun to shed light on the neural correlates of physiologically-reversible altered states of consciousness such as deep sleep, anesthesia, and psychedelic experiences. The emerging consensus is that normal waking consciousness requires the exploration of a dynamical repertoire enabling both global integration i.e., long-distance interactions between brain regions, and segregation, i.e., local processing in functionally specialized clusters. Altered states of consciousness have notably been characterized by a tipping of the integration/segregation balance away from this equilibrium...
2023: Front Netw Physiol
https://read.qxmd.com/read/38100331/where-do-we-stand-on-fmri-in-awake-mice
#15
JOURNAL ARTICLE
Francesca Mandino, Stella Vujic, Joanes Grandjean, Evelyn M R Lake
Imaging awake animals is quickly gaining traction in neuroscience as it offers a means to eliminate the confounding effects of anesthesia, difficulties of inter-species translation (when humans are typically imaged while awake), and the inability to investigate the full range of brain and behavioral states in unconscious animals. In this systematic review, we focus on the development of awake mouse blood oxygen level dependent functional magnetic resonance imaging (fMRI). Mice are widely used in research due to their fast-breeding cycle, genetic malleability, and low cost...
December 13, 2023: Cerebral Cortex
https://read.qxmd.com/read/38063007/differential-effect-of-global-signal-regression-between-awake-and-anesthetized-conditions-in-mice
#16
JOURNAL ARTICLE
Da Wang, Hui Li, Mengyang Xu, Binshi Bo, Mengchao Pei, Zhifeng Liang, Garth J Thompson
In resting-state functional MRI (rs-fMRI) studies, global signal regression (GSR) is a controversial preprocessing strategy. It effectively eliminates global noise driven by motion and respiration but also can introduce artifacts and remove functionally relevant metabolic information. Most preclinical rs-fMRI studies are performed in anesthetized animals, and anesthesia will alter both metabolic and neuronal activity. In this study, we explored the effect of GSR on rs-fMRI data collected under anesthetized and awake state in mice...
December 8, 2023: Brain Connectivity
https://read.qxmd.com/read/38056790/point-of-care-ultrasound-in-pediatrics-a-review-and-update
#17
REVIEW
Saul Flores, Erik Su, Justin M Moher, Adam C Adler, Alan F Riley
Point-Of-Care-Ultrasound (POCUS) has encountered a tremendous expansion in patient care. POCUS has taken a central role during invasive procedures. POCUS has expanded to most subspecialties from adult to pediatric and neonatal health care. POCUS in pediatrics has also become part of specific critical situations such as myocardial function assessment during cardiac arrest, ECMO deployment and neurological evaluation. In this review we will go over the most important historical aspects of POCUS. We will also review important aspects of POCUS in the intensive care unit, cardiologist evaluation and in the emergency department among others...
December 4, 2023: Seminars in Ultrasound, CT, and MR
https://read.qxmd.com/read/38030651/characteristic-dynamic-functional-connectivity-during-sevoflurane-induced-general-anesthesia
#18
JOURNAL ARTICLE
Jingya Miao, Mohamed Tantawi, Mahdi Alizadeh, Sara Thalheimer, Faezeh Vedaei, Victor Romo, Feroze B Mohamed, Chengyuan Wu
General anesthesia (GA) during surgery is commonly maintained by inhalational sevoflurane. Previous resting state functional MRI (rs-fMRI) studies have demonstrated suppressed functional connectivity (FC) of the entire brain networks, especially the default mode networks, transitioning from the awake to GA condition. However, accuracy and reliability were limited by previous administration methods (e.g. face mask) and short rs-fMRI scans. Therefore, in this study, a clinical scenario of epilepsy patients undergoing laser interstitial thermal therapy was leveraged to acquire 15 min of rs-fMRI while under general endotracheal anesthesia to maximize the accuracy of sevoflurane level...
November 29, 2023: Scientific Reports
https://read.qxmd.com/read/37969535/clinical-outcomes-and-cost-effectiveness-of-manipulation-under-brachial-plexus-block-versus-physiotherapy-for-refractory-frozen-shoulder-a-prospective-observational-study
#19
JOURNAL ARTICLE
Tomohiro Saito, Junichiro Hamada, Hideyuki Sasanuma, Yuki Iijima, Akihiro Saitsu, Hiroshi Minagawa, Wataru Kurashina, Katsushi Takeshita
BACKGROUND: Frozen shoulder (FS) is a pathological condition that involves a painful and stiff shoulder joint, most commonly in people aged 40-60 years. Most literature supports treatment with physical therapy (PT), although some studies have demonstrated years of continuing pain and functional deficits. Manipulation under anesthesia is effective at eliminating the contracture of intra-articular lesions for refractory FS. This study aimed to compare whether manipulation under anesthesia or PT is a more effective treatment in refractory FS...
November 2023: JSES international
https://read.qxmd.com/read/37957651/experience-of-early-life-pain-in-premature-infants-is-associated-with-atypical-cerebellar-development-and-later-neurodevelopmental-deficits
#20
JOURNAL ARTICLE
Kevin M Cook, Josepheen De Asis-Cruz, Jung-Hoon Kim, Sudeepta K Basu, Nickie Andescavage, Jonathan Murnick, Emma Spoehr, Melissa Liggett, Adré J du Plessis, Catherine Limperopoulos
BACKGROUND: Infants born very and extremely premature (V/EPT) are at a significantly elevated risk for neurodevelopmental disorders and delays even in the absence of structural brain injuries. These risks may be due to earlier-than-typical exposure to the extrauterine environment, and its bright lights, loud noises, and exposures to painful procedures. Given the relative underdeveloped pain modulatory responses in these infants, frequent pain exposures may confer risk for later deficits...
November 14, 2023: BMC Medicine
keyword
keyword
161421
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.