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https://www.readbyqxmd.com/read/30343390/advanced-glycated-end-products-alter-neutrophil-effect-on-regulation-of-cd-4-t-cell-differentiation-through-induction-of-myeloperoxidase-and-neutrophil-elastase-activities
#1
Haike Lu, Sanqing Xu, Xiaoyu Liang, Yingyi Dai, Zhixin Huang, Yumin Ren, Jianguo Lin, Xintong Liu
CD4 + T cell subset imbalance plays an important role in the development of diabetic complications. Neutrophils have recently been known as the regulator of CD4 + T cell differentiation. However, whether neutrophils affect CD4 + T cell population in diabetes is still elusive. In this study, we investigated the effect of neutrophils stimulated with advanced glycated end products (AGEs), the marker of diabetes, on CD4 + T cell differentiation and its underlying mechanism. Our data showed that the cultural medium of healthy adult neutrophils treated with AGEs increased expressions of both Th1 (IFN-γ) and Th17 (IL-17) phenotypes and the transcription factors of Th1 (Tbet) and Th17 (RORγt) in naive CD4 + T cells and CD4 + CD25 + FoxP3 + (Treg) T cells in vitro...
October 20, 2018: Inflammation
https://www.readbyqxmd.com/read/30342474/asca-and-anca-among-bedouin-arabs-with-inflammatory-bowel-disease-the-frequency-and-phenotype-correlation
#2
Naim Abu-Freha, Wafi Badarna, Ina Sigal-Batikoff, Muhammad Abu Tailakh, Ohad Etzion, Jaber Elkrinawi, Arik Segal, Alex Mushkalo, Alex Fich
BACKGROUND: Serological markers used for diagnostic purposes and disease stratification in inflammatory bowel disease. We aimed to investigate the frequency of ASCA and ANCA among Arab Bedouin IBD patients and its relationship to disease phenotype and course. METHODS: From cohort of 68, 25 Crohn's disease (CD) and 25 Ulcerative colitis (UC) patients were recruited (72%). ASCA IgG was determined by ELISA assay. Immunofluorescence analysis of ANCA was performed. RESULTS: The IgG ASCA was detected in 13 (52%) of the CD patients and in three (12%) UC patients...
October 20, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/30335243/flow-cytometry-in-peripheral-blood-reticulocytes-as-a-marker-of-chromosome-instability-in-highgrade-glioma-patients
#3
Lina Marcela Barrera, León Darío Ortiz, Hugo Grisales, Mauricio Rojas, Mauricio Camargo
Introduction: The quantification of chromosomal instability is an important parameter to assess genotoxicity and radiosensitivity. Most conventional techniques require cell cultures or laborious microscopic analyses of chromosomes or nuclei. However, a flow cytometry that selects the reticulocytes has been developed as an alternative for in vivo studies, which expedites the analytical procedures and increases up to 20 times the number of target cells to be analyzed. Objectives: To standardize the flow cytometry parameters for selecting and quantifying the micronucleated reticulocytesCD71+ (MN-RET) from freshly drawn peripheral blood and to quantify the frequency of this abnormal cell subpopulation as a measure of cytogenetic instability in populations of healthy volunteers (n =25), and patients (n=25), recently diagnosed with high-grade gliomas before the onset of treatment...
September 1, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/30327714/reduced-susceptibility-to-sugar-induced-metabolic-derangements-and-impairments-of-myocardial-redox-signaling-in-mice-chronically-fed-with-d-tagatose-when-compared-to-fructose
#4
Debora Collotta, Laura Lucarini, Fausto Chiazza, Alessia Sofia Cento, Mariaconcetta Durante, Silvia Sgambellone, Jacopo Chini, Francesca Baratta, Manuela Aragno, Raffaella Mastrocola, Emanuela Masini, Massimo Collino
Background: D-tagatose is an isomer of fructose and is ~90% as sweet as sucrose with less caloric value. Nowadays, D-tagatose is used as a nutritive or low-calorie sweetener. Despite clinical findings suggesting that D-tagatose could be beneficial in subjects with type 2 diabetes, there are no experimental data comparing D-tagatose with fructose, in terms of metabolic derangements and related molecular mechanisms evoked by chronic exposure to these two monosaccharides. Materials and methods: C57Bl/6j mice were fed with a control diet plus water (CD), a control diet plus 30% fructose syrup (L-Fr), a 30% fructose solid diet plus water (S-Fr), a control diet plus 30% D-tagatose syrup (L-Tg), or a 30% D-tagatose solid diet plus water (S-Tg), during 24 weeks...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30327331/screening-for-coeliac-disease-in-1624-mainly-asymptomatic-children-with-type-1-diabetes-is-genotyping-for-coeliac-specific-human-leucocyte-antigen-the-right-approach
#5
Elisabeth Binder, Tilmann Rohrer, Christian Denzer, Wolfgang Marg, Ute Ohlenschläger, Heike Schenk-Huber, Ulrike Schierloh, Heino Skopnik, Elke Elisabeth Fröhlich-Reiterer, Reinhard W Holl, Nicole Prinz
OBJECTIVES: To investigate the frequency of coeliac disease (CD)-specific human leucocyte antigen (HLA) genotypes in paediatric patients with type 1 diabetes (T1D), who are known to have a higher prevalence of CD than the general population, and to evaluate whether HLA genotyping is a suitable first-line screening method for CD. STUDY DESIGN: The study was a multicentre observational analysis of patients with T1D aged <20 years of whom a subgroup had undergone HLA genotyping...
October 16, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/30326065/binocular-summation-in-postillumination-pupil-response-driven-by-melanopsin-containing-retinal-ganglion-cells
#6
Marija Zivcevska, Alan Blakeman, Shaobo Lei, Herbert C Goltz, Agnes M F Wong
Purpose: To investigate how melanopsin-mediated intrinsically photosensitive retinal ganglion cell (ipRGC) signals are integrated binocularly using chromatic pupillometry. We hypothesized that if the melanopsin system is summative, there will be a greater postillumination pupillary response (PIPR) under binocular conditions after viewing bright blue light. Methods: Pupillary responses in 10 visually normal participants were recorded with an eye tracker following full-field stimulation of red (long wavelength) and blue (short wavelength) light of equal intensity (dim: 0...
October 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30324113/lack-of-association-between-interleukin-23r-il-23r-rs10889677-polymorphism-and-inflammatory-bowel-disease-susceptibility-in-an-iranian-population
#7
Sara Karimkhani, Vahid Chaleshi, Hedieh Balaii, Peyman Tarban, Mahyar Nourian, Shiva Irani, Shabnam Shahrokh, Hamid Asadzadeh Aghdaei, Amir Houshang Mohammad Alizadeh, Mohsen Norouzinia, Mohammad Reza Zali
Background: Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn's disease (CD), are inflammatory disorders that affect the gastrointestinal tract. A combination of inflammatory cytokines has an important role in IBD development. Genome-wide association studies have shown that polymorphisms in the interleukin-23R gene ( IL-23R ) increase susceptibility to IBD. The aim of this study was to investigate the IL-23R 3' UTR SNP to determine a potential association between genotype distribution and IBD...
October 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/30321750/reduction-of-high-fat-diet-induced-liver-proinflammatory-state-by-eicosapentaenoic-acid-plus-hydroxytyrosol-supplementation-involvement-of-resolvins-rve1-2-and-rvd1-2
#8
F Echeverría, R Valenzuela, A Espinosa, A Bustamante, D Álvarez, D Gonzalez-Mañan, M Ortiz, S A Soto-Alarcon, L A Videla
High-fat diet (HFD)-fed mice show obesity with development of liver steatosis and a proinflammatory state without establishing an inflammatory reaction. The aim of this work was to assess the hypothesis that eicosapentaenoic acid (EPA) plus hydroxytyrosol (HT) supplementation prevents the inflammatory reaction through enhancement in the hepatic resolvin content in HFD-fed mice. Male C57BL/6J mice were fed an HFD or a control diet and supplemented with EPA (50 mg/kg/day) and HT (5 mg/kg/day) or their respective vehicles for 12 weeks...
September 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/30321230/tissue-microarray-analysis-delineate-potential-prognostic-role-of-annexin-a7-in-prostate-cancer-progression
#9
Ximena Leighton, Alakesh Bera, Ofer Eidelman, Lukas Bubendorf, Tobias Zellweger, Jaideep Banerjee, Edward P Gelmann, Harvey B Pollard, Meera Srivastava
BACKGROUND: Annexin A7 (ANXA7) is a member of the multifunctional calcium or phospholipid-binding annexin gene family. While low levels of ANXA7 are associated with aggressive types of cancer, the clinical impact of ANXA7 in prostate cancer remains unclear. Tissue microarrays (TMA) have revealed several new molecular markers in human tumors. Herein, we have identified the prognostic impact of ANXA7 in a prostate cancer using a tissue microarray containing 637 different specimens. METHODS: The patients were diagnosed with prostate cancer and long-term follow-up information on progression (median 5...
2018: PloS One
https://www.readbyqxmd.com/read/30320350/tgf-%C3%AE-1-secreted-by-m2-phenotype-macrophages-enhances-the-stemness-and-migration-of-glioma-cells-via-the-smad2-3-signalling-pathway
#10
Zhengzheng Liu, Weilu Kuang, Qin Zhou, Yingying Zhang
The positive correlation between the number of M2 phenotype TAMs (M2‑TAMs) and tumour development suggests a supportive role of M2‑TAMs in glioma progression. In the present study, the molecular link between glioma cells and M2‑TAMs was investigated and it was demonstrated that transforming growth factor‑β1 (TGF‑β1) secreted by M2‑TAMs is key in facilitating the stemness and migration of glioma cells. Cluster of differentiation (CD)133 and CD44, markers for the M2 phenotype, were assessed by western blotting...
October 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30319193/can-high-titres-of-anti-tissue-transglutaminase-antibodies-reduce-the-need-for-intestinal-biopsy-for-diagnosis-of-celiac-disease
#11
Ekta Bansal, Navpreet Kaur, Naveen Mittal
Traditionally small intestinal biopsy has been considered a gold standard for the diagnosis of celiac disease (CD). But now data has shown that serological markers like anti-tissue-transglutaminase antibodies (tTGA) can be used to make the diagnosis with great sensitivity and specificity. The objective of the present study was to evaluate whether patients with high probability of CD and high titre of tTGA, have a high probability of intestinal damage and may not require biopsy for final diagnosis. All the cases with tTGA levels ≥15 IU/ml and who subsequently underwent biopsy from July 2010 to June 2013 were selected...
October 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/30317844/the-usefulness-of-immunocytochemistry-of-cd56-in-determining-malignancy-from-indeterminate-thyroid-fine-needle-aspiration-cytology
#12
Hyunseo Cha, Ju Yeon Pyo, Soon Won Hong
Background: Fine Needle Aspiration Cytology (FNAC) serves as a safe, economical tool in evaluating thyroid nodules. However, about 30% of the samples are categorized as indeterminate. Hence, many immunocytochemistry (ICC) markers have been studied, but there has not been a single outstanding marker. We studied the efficacy of CD56 with HBME-1 in diagnosis in Bethesda Reporting System of Thyroid (TBRST) category III. Materials and Methods: We reviewed thin prep liquid-based cytology (LBC) samples with Papanicolaou stain from July 1 to December 31, 2016 (2195 cases) and selected TBRST category III cases (n=363)...
October 15, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/30317122/obesity-activated-adipose-derived-stromal-cells-promote-breast-cancer-growth-and-invasion
#13
Lauren E Hillers, Joseph V D'Amato, Tamara Chamberlin, Gretchen Paderta, Lisa M Arendt
Obese women diagnosed with breast cancer have an increased risk for metastasis, and the underlying mechanisms are not well established. Within the mammary gland, adipose-derived stromal cells (ASCs) are heterogeneous cells with the capacity to differentiate into multiple mesenchymal lineages. To study the effects of obesity on ASCs, mice were fed a control diet (CD) or high-fat diet (HFD) to induce obesity, and ASCs were isolated from the mammary glands of lean and obese mice. We observed that obesity increased ASCs proliferation, decreased differentiation potential, and upregulated expression of α-smooth muscle actin, a marker of activated fibroblasts, compared to ASCs from lean mice...
October 11, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/30316725/tinospora-cordifolia-extract-prevents-cadmium-induced-oxidative-stress-and-hepatotoxicity-in-experimental-rats
#14
Rathinasamy Baskaran, Lohanathan Bharathi Priya, V Sathish Kumar, Viswanadha Vijaya Padma
BACKGROUND: Cadmium (Cd) pollution is of serious concern due to its toxic effects in both humans and animals. The study investigates the protective effect of Tinospora cordifolia stem methanolic extract (TCME) on Cd induced hepatotoxicity. OBJECTIVE: The aim of the study was to explore the hepatoprotective effects of T. cordifolia extract. MATERIALS AND METHODS: Rats were administered orally with Cd (5 mg/kg) and TCME (100 mg/kg) for 28 days...
October 10, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/30314368/hydrophilic-astragalin-galactoside-induces-t-helper-type-1-mediated-immune-responses-via-dendritic-cells
#15
Jae Hyoung Jeon, Byung-Cheol Lee, Doman Kim, Daeho Cho, Tae Sung Kim
A flavonoid Astragalin (kaempferol-3- O -β-d-glucopyranoside, Ast) has several biological activities including anti-oxidant, anti-HIV, and anti-allergic effects. Nonetheless, its insolubility in hydrophilic solvents imposes restrictions on its therapeutic applications. In this study, we investigated the effects of water-soluble astragalin-galactoside (kaempferol-3- O -β-d-isomaltotrioside, Ast-Gal) on murine bone marrow-derived dendritic cell (DC) maturation and T helper (Th) cell-mediated immune responses...
October 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30314292/correlation-of-paraoxonase-1-with-the-severity-of-crohn-s-disease
#16
Katarzyna Szczeklik, Tomasz Mach, Dorota Cibor, Danuta Owczarek, Jacek Sapa, Monika Papież, Jolanta Pytko-Polończyk, Wirginia Krzyściak
Diagnostics of Crohn's disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD. The CD activity index was based on the current classification. Plasma PON-1 was measured in 47 patients with CD, and in 23 control volunteers. Using quantitative variables such as receiver operating characteristics (ROC) (area under the curve (AUC)), the diagnostic utility of PON-1 in differentiating the severity of CD was assessed...
October 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30311156/prevalence-and-clinical-features-of-celiac-disease-in-healthy-school-aged-children
#17
Omer Faruk Beser, Emine Gulluelli, Fugen Cullu Cokugras, Tulay Erkan, Tufan Kutlu, Rasit Vural Yagci, Firuze Erbek Alp, Gulten Ercal, Nuray Kepil, Mine Kucur
BACKGROUND/AIMS: The aim of this study was to determine the prevalence of celiac disease (CD) in healthy school-aged children in the northern region of Cyprus and to investigate the existence of potential markers that may accompany CD. This is the first study to measure the prevalence of CD in the northern region of Cyprus. METHODS: This study included 3792 school-aged children who were between the ages of 6 and 10 years between January 2015 and October 2016. CD was screened using total serum IgA, IgA anti-tissue transglutaminase (tTG), and IgA antiendomysial (EMA) antibodies...
October 12, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30310949/historical-pollution-of-an-urban-watershed-based-in-geochemical-geoacumulation-and-erod-activity-in-plhc-1-analyses-in-sediment-cores
#18
L M Vieira, J Rizzi, E V do Couto, D C Souza, P A L Ferreira, R Figueira, S Froehner
In the present study, the environmental changes over the past 100 years in the Cambé River watershed in Southern Brazil were investigated. For this, a sediment core was collected to examine the distribution of metals, polycyclic aromatic hydrocarbons (PAHs), and ecotoxicological markers. The core corresponds from 1914 to 2012, which was obtained by the decay of 210 Pb. Changes in the study area also were examined by: Geoaccumulation index (Igeo) and enrichment factor (EF), sediment quality guidelines (SGQs), and ethoxyresorufin-O-deethylase (EROD) activity in Poeciliopsis lucida hepatocellular carcinoma (PLHC-1) cells line...
October 11, 2018: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/30310786/syndecan-1-scd138-levels-in-chronic-lymphocytic-leukemia-clinical-and-hematological-correlations
#19
Monica Sharma, Seema Tyagi, Preeti Tripathi, Tulika Seth
Background: Syndecan-1 (sCD138) has recently been suggested to predict the clinical course of early-stage chronic lymphocytic leukemia (CLL), but few studies have been reported. This study assessed the role of syndecan-1 in the prognosis of patients with CLL and its correlation with other prognostic markers. Methods: This prospective study was performed in the hematology department of an Indian tertiary care center, over nineteen months (Jun. 2009-Jan. 2011). Forty-nine new patients with CLL presented during this period and were included...
September 2018: Blood Research
https://www.readbyqxmd.com/read/30305562/nephroprotective-effect-of-essential-oils-from-ginger-zingiber-officinale-and-turmeric-curcuma-longa-rhizomes-against-cadmium-induced-nephrotoxicity-in-rats
#20
Ayodele Jacob Akinyemi, Oluwabamise Lekan Faboya, Awonegan Ayodeji Paul, Israel Olayide, Opeyemi Ayodeji Faboya, Titus Ademola Oluwasola
Several studies have shown that cadmium (Cd) induces nephrotoxicity and many plant foods phytochemicals have been found useful but their possible mechanism of action still remains unexplored. Hence, this study aimed to investigate the nephroprotective effect of essential oils from Nigeria ginger and turmeric rhizomes in cadmium-treated rats by examining their effect on renal function biomarkers (creatinine, urea and BUN), inflammatory cytokines (IL-6, IL-10 and TNF-Alpha) and renal adenosine deaminase (ADA) activity...
2018: Journal of Oleo Science
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