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https://www.readbyqxmd.com/read/30549210/biomaterial-induced-multinucleated-giant-cells-express-proinflammatory-signaling-molecules-a-histological-study-in-humans
#1
Yunxin Zhang, Sarah Al-Maawi, Xuejiu Wang, Robert Sader, C James Kirkpatrick, Shahram Ghanaati
The biomaterials physicochemical characteristics influence their cellular reaction, degradation and regenerative capacities. Macrophages and multinucleated giant cells (MNGCs) are observed in the augmentation area of biomaterials. This study, for the first time, evaluated the polarization pattern of macrophages and MNGCs in response to two different bone substitute materials (synthetic bone substitute material (SBSM) = NanoBone® vs. xenogeneic bone substitute material (XBSM) = Bio-Oss®) in human bone biopsies compared to non-augmented bone (control)...
December 13, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30546886/radiotherapy-associated-intra-abdominal-angiosarcoma-after-prostatic-adenocarcinoma-case-reports
#2
David Parada Domínguez, Karla B Peña Gonzalez
Angiosarcoma is a rare soft tissue neoplasm, which accounts for <1% of all soft tissue tumours. It has been previously reported that the incidence rate of angiosarcomas increases following radiotherapy. The present study reports two cases of intra-abdominal angiosarcoma associated with previous radiotherapy treatment. To the best of our knowledge, these associations have not been previously described in English literature. The patients aged 71 and 83 years were admitted to the center for abdominal pain and diarrhea...
December 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30546432/clinical-diagnosis-of-adult-patients-with-acute-megakaryocytic-leukemia
#3
Guangjie Zhao, Wanling Wu, Xiaoqin Wang, Jingwen Gu
Acute megakaryocytic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML), which is challenging to diagnose due to frequent myelofibrosis (MF) and a low percentage of blast cells. In the present study, clinical characteristics and experimental observations in 9 adult patients diagnosed with AMKL, who were recruited by the Sino-U.S. Shanghai Leukemia Co-operative Group, were analyzed in order to summarize the diagnostic experience and provide recommendations on diagnosing AMKL. All the patients were diagnosed according to the 2008 World Health Organization diagnostic criteria...
December 2018: Oncology Letters
https://www.readbyqxmd.com/read/30542473/simultaneous-isolation-of-mesenchymal-stem-cells-and-endothelial-progenitor-cells-derived-from-murine-bone-marrow
#4
Xiaoyi Wang, Zongsheng Zhao, Hongwei Zhang, Jixue Hou, Wenlei Feng, Meng Zhang, Jun Guo, Jie Xia, Quanhu Ge, Xueling Chen, Xiangwei Wu
Mesenchymal stem or stromal cells (MSCs) are identified as sources of pluripotent stem cells with varying degrees of plasticity. Endothelial progenitor cells (EPCs) originate from either bone marrow (BM) or peripheral blood and can mature into cells that line the lumen of blood vessels. MSC and EPC therapies exhibit promising results in a variety of diseases. The current study described the simultaneous isolation of EPCs and MSCs from murine BM using a straightforward approach. The method is based on differences in attachment time and trypsin sensitivity of MSCs and EPCs...
December 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30542318/immunotoxin-induced-ablation-of-the-intrinsically-photosensitive-retinal-ganglion-cells-in-rhesus-monkeys
#5
Lisa A Ostrin, Christianne E Strang, Kevin Chang, Ashutosh Jnawali, Li-Fang Hung, Baskar Arumugam, Laura J Frishman, Earl L Smith, Paul D Gamlin
Purpose: Intrinsically photosensitive retinal ganglion cells (ipRGCs) contain the photopigment melanopsin, and are primarily involved in non-image forming functions, such as the pupillary light reflex and circadian rhythm entrainment. The goal of this study was to develop and validate a targeted ipRGC immunotoxin to ultimately examine the role of ipRGCs in macaque monkeys. Methods: An immunotoxin for the macaque melanopsin gene ( OPN4 ), consisting of a saporin-conjugated antibody directed at the N-terminus, was prepared in solutions of 0...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30541458/exclusive-enteral-nutrition-with-concomitant-early-thiopurine-use-was-effective-in-maintaining-steroid-free-remission-in-a-southeast-asian-cohort-of-children-with-crohn-s-disease
#6
Christina Ong, Poh Ting Lim, Veena Logarajah, Maria Janelle Liwanag, Bi Xia Ang, Yuqin Cher, Fang Kuan Chiou, Ajmal Kader
BACKGROUND: Exclusive enteral nutrition (EEN) is as effective as corticosteroids in inducing remission in children with Crohn's disease (CD). However, over 50% of these children relapse by 12 months of diagnosis. Thiopurines are commonly prescribed as maintenance therapy for CD, but evidence for its efficacy is controversial. Data on the effectiveness of EEN in Southeast Asian (SEA) children with CD is scarce. This study aims to evaluate the efficacy of EEN induction therapy in a cohort of SEA children with newly diagnosed CD...
December 12, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/30541015/mucosal-healing-and-bacterial-composition-in-response-to-enteral-nutrition-versus-steroid-based-induction-therapy-a-randomized-prospective-clinical-trial-in-children-with-crohn-s-disease
#7
Bénédicte Pigneur, Patricia Lepage, Stanislas Mondot, Jacques Schmitz, Olivier Goulet, Joël Doré, Frank M Ruemmele
Exclusive Enteral Nutrition (EEN) is as efficacious as corticosteroids (CS) to induce remission in Crohn's disease (CD), without their adverse effects. EEN seems to be more efficient than steroids to induce mucosal healing, but the underlying molecular mechanisms are only sparsely understood. We aimed in the present work to study the anti-inflammatory effects of EEN with Modulen IBD® versus CS in active pediatric CD and to assess its modulatory effects on the intestinal microbiota as compared to steroids. MATERIAL AND METHODS: Nineteen patients with new-onset active CD (Harvey Bradshaw index HBI> 5), aged from 6 to 17 years, were included in this prospective randomized induction trial with CS (n=6) or EEN (n=13)...
December 12, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/30540997/gastric-focal-neutrophil-infiltration-and-wide-duodenal-gastric-foveolar-metaplasia-are-histologic-discriminative-markers-for-crohn-s-disease-and-beh%C3%A3-et-s-disease
#8
Yui Akemoto, Hirotake Sakuraba, Masanori Tanaka, Hiroto Hiraga, Hidezumi Kikuchi, Satoko Morohashi, Shinji Ota, Keisuke Hasui, Miwa Satake, Rina Watanabe, Nahoko Tanaka, Shogo Kawaguchi, Tetsuya Tatsuta, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Yoh Ishiguro, Hiroshi Kijima, Shinsaku Fukuda
BACKGROUND/AIMS: Behçet's disease (BD) with intestinal lesions and Crohn's disease (CD) share clinical features. However, no report has compared the 2 diseases with regard to lesions of the upper gastrointestinal tract (UGT). We aimed to evaluate endoscopic and histologic findings of UGT in CD and BD. METHODS: We retrospectively assessed the endoscopic records and biopsy samples of 84 Helicobacter pylori-negative patients (50 CD, 34 BD). In duodenal samples, MUC5AC immunohistochemical analysis was performed to identify gastric foveolar metaplasia...
December 12, 2018: Digestion
https://www.readbyqxmd.com/read/30534627/granulocyte-macrophage-colony-stimulating-factor-receptor-expression-in-clinical-pain-disorder-tissues-and-role-in-neuronal-sensitization
#9
Philippe Donatien, Uma Anand, Yiangos Yiangou, Marco Sinisi, Michael Fox, Anthony MacQuillan, Tom Quick, Yuri E Korchev, Praveen Anand
Introduction: Granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) is highly expressed in peripheral macrophages and microglia, and is involved in arthritis and cancer pain in animal models. However, there is limited information on GM-CSFR expression in human central nervous system (CNS), peripheral nerves, or dorsal root ganglia (DRG), particularly in chronic pain conditions. Objectives: Immunohistochemistry was used to quantify GM-CSFR expression levels in human tissues, and functional sensory effects of GM-CSF were studied in cultured DRG neurons...
September 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/30530902/inhibitors-of-apoptosis-protect-the-ovarian-reserve-from-cyclophosphamide
#10
Yi Luan, Maxwell E Edmonds, Teresa K Woodruff, So-Youn Kim
Cancer therapy can cause off-target effects including ovarian damage, which may result in primary ovarian insufficiency in girls and premenopausal women. Loss of ovarian follicles within the ovarian reserve leads to ovarian endocrine dysfunction and impaired fertility. Cyclophosphamide (CPA), a commonly used chemotherapeutic and immunosuppressant agent, is a gonadotoxic agent that destroys ovarian cells by crosslinking DNA. To protect the ovary against CPA damage, we sought to precisely map the mechanism by which the ovarian reserve is depleted by CPA...
February 1, 2019: Journal of Endocrinology
https://www.readbyqxmd.com/read/30528912/variability-in-nitrate-reducing-oral-bacteria-and-nitric-oxide-metabolites-in-biological-fluids-following-dietary-nitrate-administration-an-assessment-of-the-critical-difference
#11
Luke Liddle, Mia C Burleigh, Chris Monaghan, David J Muggeridge, Nicholas Sculthorpe, Charles R Pedlar, John Butcher, Fiona L Henriquez, Chris Easton
There is conflicting evidence on whether dietary nitrate supplementation can improve exercise performance. This may arise from the complex nature of nitric oxide (NO) metabolism which causes substantial inter-individual variability, within-person biological variation (CVB ), and analytical imprecision (CVA ) in experimental endpoints. However, no study has quantified the CVA and CVB of NO metabolites or the factors that influence their production. These data are important to calculate the critical difference (CD), defined as the smallest difference between sequential measurements required to signify a true change...
December 5, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/30523133/predicting-outcomes-for-crohn-s-disease-using-a-molecular-biomarker-profile-protocol-for-a-multicentre-randomised-biomarker-stratified-trial
#12
Miles Parkes, Nurulamin M Noor, Francis Dowling, Harvey Leung, Simon Bond, Lynne Whitehead, Sara Upponi, Paul Kinnon, Andrew P Sandham, Paul A Lyons, Eoin F McKinney, Kenneth G C Smith, James C Lee
BACKGROUND: The course of Crohn's disease (CD) varies substantially between individuals, but reliable prognostic markers do not exist. This hinders disease management because patients with aggressive disease are undertreated by conventional 'step-up' therapy (in which treatment is gradually escalated in response to refractory or relapsing disease) while those with more indolent disease would be exposed to unnecessary treatment-related toxicity if a more aggressive 'top-down' approach was indiscriminately used...
December 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/30522193/-signaling-pathway-of-m2-type-polarization-induced-by-mycobacterium-tuberculosis-specific-peptide-e7-in-monocyte-macrophages
#13
H J Meng, J Wang, Y M Fang, D M Shen, L Mao, H B Kuang, H J Qin, X M Lai, S Y Tan
Objective: To explore the signal pathway of M2-type polarization induced by Mycobacterium tuberculosis (MTB)-specific peptide E7. Methods: Monocyte-macrophages were divided into blank control group, M1 positive stimulus group [co-stimulated with lipopolysaccharide and gamma interferon (IFN-γ)], M2 positive group(co-stimulated with IL-4 and IL-13), and E7 experimental group (with MTB-specificity polypeptide E7 stimulated). The expression of M1 type markers CD(16), IL-6, TNF-α and M2 type markers CD(163), CD(206), IL-10 were detected at 12, 18, 24 and 36 h...
December 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/30515402/peripheral-lymphocytes-of-patients-with-inflammatory-bowel-disease-have-altered-concentrations-of-key-apoptosis-players-preliminary-results
#14
Katarzyna Neubauer, Barbara Woźniak-Stolarska, Małgorzata Krzystek-Korpacka
Notwithstanding uncertain pathogenesis of inflammatory bowel disease (IBD), deregulation of adaptive immunity is paramount for the development of inflammation. Essential role in the resolution of inflammation is played by apoptosis, deregulated in lymphocytes isolated from inflamed intestine. Despite IBD being a systemic disease, little is known about apoptosis of peripheral lymphocytes. The concentrations of Bcl-2, cytochrome c, p53, and caspase-9 were determined (ELISA) in lymphocyte-enriched fractions of peripheral blood mononuclear cells (LE-PBMCs) from 64 individuals (42 with IBD) and related to IBD phenotype and activity, treatment, and inflammatory and hematological indices...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30514224/prolonged-operative-time-of-repeat-cesarean-is-a-risk-marker-for-post-operative-maternal-complications
#15
Misgav Rottenstreich, Hen Y Sela, Ori Shen, Rachel Michaelson-Cohen, Arnon Samueloff, Orna Reichman
BACKGROUND: Repeat cesarean delivery (CD) accounts for approximately 15% of all annual deliveries in the US with an estimated 656,250 operations per year. We aimed to study whether prolonged operative time (OT; skin incision to closure) is a risk marker for post-operative maternal complications among women undergoing repeat CD. METHODS: We conducted a cross-sectional retrospective study in a single tertiary center including all women who underwent repeat CD but excluding those with cesarean hysterectomy...
December 4, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/30509646/impact-of-different-seasons-on-the-milk-somatic-and-differential-cell-counts-milk-cortisol-and-neutrophils-functionality-of-three-indian-native-breeds-of-cattle
#16
Mohanned Naif Alhussien, Ajay Kumar Dang
The present study was undertaken to compare the effect of different seasons on the mammary immunity of three Indian native breeds of cows (Tharparkar, Gir and Sahiwal) well adapted to the tropical region. For this milk samples were collected from cows in winter (THI=57, comfortable zone), hot-dry (HD; THI=76, heat stressful zone) and hot-humid (HH; THI = 82, severe heat stress) and estimated for milk somatic cell counts (SCC), phagocytic activity (PA) of milk neutrophils, milk cortisol and heat shock proteins and function associated genes in milk neutrophils...
December 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/30500964/impact-of-gestational-weight-gain-on-trial-of-labor-after-cesarean-success
#17
Jenny Y Mei, Alexandra L Havard, Amanda J Mularz, Melanie M Maykin, Stephanie L Gaw
OBJECTIVE:  Excessive gestational weight gain (GWG) has been associated with adverse pregnancy outcomes, including increased risk of cesarean delivery (CD). Data are limited on associations between GWG and outcomes in women undergoing trial of labor after cesarean (TOLAC). We aimed to investigate whether appropriate GWG impacts TOLAC outcomes. STUDY DESIGN:  We performed a retrospective cohort study of women undergoing TOLAC at a single institution from May 2007 to April 2016...
November 30, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/30500938/risk-of-myocardial-infarction-in-inflammatory-bowel-disease-a-population-based-national-study
#18
Muhammad Siyab Panhwar, Emad Mansoor, Sadeer G Al-Kindi, Preetika Sinh, Jeffry Katz, Guilherme H Oliveira, Gregory S Cooper, Mahazarin Ginwalla
Background & Objective: Chronic inflammation is linked to increased cardiovascular risk. Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and elevated pro-inflammatory markers. The association between IBD and myocardial infarction (MI) is not well understood. We sought to elucidate this risk using a large database. Methods: We reviewed data from a large commercial database (Explorys, IBM Watson) that aggregates electronic medical records from 26 nationwide health care systems...
November 30, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/30497027/inflammatory-changes-during-canine-pregnancy
#19
Bodil S Holst, Malin H Gustavsson, Anders Johannisson, Anna Hillström, Emma Strage, Ulf Olsson, Eva Axnér, Inger Lilliehöök
Pregnancy is considered a pro-inflammatory state that requires physiologic adaptation of the immune system of the mother. The aim of the present study was to study inflammatory and hormonal changes during canine pregnancy. Studies included analyses of peripheral concentrations of the acute phase proteins fibrinogen and C-reactive protein (CRP), the hormones progesterone and insulin-like growth factor I (IGF-I), hemoglobin, and analyses of the total leukocyte numbers and expression of cell surface antigens. Twenty bitches were included in the present study; 12 pregnant bitches and eight non-pregnant control bitches that were followed during the corresponding phase of the oestrous cycle...
November 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/30496997/salicylic-acid-altering-arabidopsis-plant-response-to-cadmium-exposure-underlying-mechanisms-affecting-antioxidation-and-photosynthesis-related-processes
#20
Yuan-Yuan Wang, Yu Wang, Guang-Zhe Li, Lin Hao
Previous studies have demonstrated that the genetic modification of basal salicylic acid (SA) level changed Arabidopsis plant response to cadmium (Cd) stress, but the mechanisms remain evaluated. In this study, Arabidopsis wild type (WT) and its SA-reducing transgenic line nahG (naphthalene hydroxylase G), SA-accumulating mutant snc1 (suppressor of nonexpressor of PR gene, constitutive 1) were exposed to 50 μM Cd2+ for 48 h or 7 d (just for assessing plant growth). The Cd treatment increased the expression levels of SA biosynthesis-related genes leading to enhanced SA accumulations in plant leaves, which was further confirmed by the expression patterns of SA marker genes...
November 26, 2018: Ecotoxicology and Environmental Safety
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