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https://www.readbyqxmd.com/read/30106451/association-between-tim%C3%A2-3-and-gal%C3%A2-9-expression-and-gastric-cancer-prognosis
#1
Yangyang Wang, Enhao Zhao, Zizhen Zhang, Gang Zhao, Hui Cao
The T‑cell immunoglobulin and mucin domain‑containing protein 3 (Tim‑3)/galectin 9 (Gal‑9) pathway, which serves a pivotal role in immune regulation, is similar to the programmed death (PD)‑1/PD‑ligand 1 pathway. Recent evidence has suggested that Tim‑3 is differentially regulated in a variety of tumors and is a potential therapeutic target. The aim of the present study was to evaluate Tim‑3 and Gal‑9 expression and cluster of differentiation (CD)3+, CD8+ and forkhead box (FOX)p3+ T cell tumor‑infiltration in gastric cancer, as well as their impact on prognosis...
August 6, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30095633/diagnostic-utility-of-serological-biomarkers-in-patients-with-crohn-s-disease-a-case-control-study
#2
Fang Yao, Yihong Fan, Bin Lv, Conghua Ji, Li Xu
The aim of this study was to examine the expression of serological markers in patients with inflammatory bowel disease in China, and determine the diagnostic utility of serological markers, individually and in combination, for the diagnosis and differential diagnosis of Crohn's disease (CD).Serum samples were obtained from 160 participants in Eastern China. Among the participants, 98 were diagnosed with CD, 33 had ulcerative colitis (UC), and 29 were healthy controls (HC). The serum samples were tested for the presence of antibodies against outer membrane porin C (anti-OmpC), Pseudomonas fluorescens bacterial sequence I2 (anti-I2), anti-laminarin (anti-L), anti-chitin (anti-C), anti-chitobioside carbohydrate antibody (ACCA), anti-laminaribioside carbohydrate antibody (ALCA), anti-mannobioside carbohydrate antibody (AMCA), and anti-Saccharomyces cerevisiae antibody (ASCA) by indirect enzyme-linked immunosorbent assay (ELISA)...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30090042/selective-m1-macrophage-polarization-in-granuloma-positive-and-granuloma-negative-crohn-s-disease-in-comparison-to-intestinal-tuberculosis
#3
Prasenjit Das, Ritika Rampal, Sonakshi Udinia, Tarun Kumar, Sucharita Pilli, Nahid Wari, Imtiaz Khan Ahmed, Saurabh Kedia, Siddhartha Datta Gupta, Dhiraj Kumar, Vineet Ahuja
Background/Aims: Classical M1 macrophage activation exhibits an inflammatory phenotype while alternative M2 macrophage activation exhibits an anti-inflammatory phenotype. We aimed to determine whether there are discriminant patterns of macrophage polarization in Crohn's disease (CD) and intestinal tuberculosis (iTB). Methods: Colonic mucosal biopsies from 29 patients with iTB, 50 with CD, and 19 controls were examined. Dual colored immunohistochemistry was performed for iNOS/CD68 (an M1φ marker) and CD163/CD68 (an M2φ marker), and the ratio of M1φ to M2φ was assessed...
July 2018: Intestinal Research
https://www.readbyqxmd.com/read/30089823/functional-characterization-of-common-bcl11b-gene-desert-variants-suggests-a-lymphocyte-mediated-association-of-bcl11b-with-aortic-stiffness
#4
Raya Al Maskari, Iris Hardege, Sarah Cleary, Nicki Figg, Ye Li, Keith Siew, Ashraf Khir, Yong Yu, Pentao Liu, Ian Wilkinson, Kevin O'Shaughnessy, Yasmin
The recent genome-wide analysis of carotid-femoral pulse wave velocity (PWV) identified a significant locus within the 14q32.2 gene desert. Gene regulatory elements for the transcriptional regulator B-cell CLL/lymphoma 11B (BCL11B) are within this locus and an attractive target for the gene association. We investigated the functional impact of these gene desert SNPs on BCL11B transcript in human aorta to characterize further its role in aortic stiffness. To do this, we used a large repository of aortic tissues (n = 185) from an organ transplant program and assessed ex vivo stiffness of the aortic rings...
August 8, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/30086261/utility-of-video-capsule-endoscopy-for-longitudinal-monitoring-of-crohn-s-disease-activity-in-the-small-bowel-a-prospective-study
#5
Gil Y Melmed, Marla C Dubinsky, David T Rubin, Mark Fleisher, Shabana F Pasha, Atsushi Sakuraba, Felix Tiongco, Ira Shafran, Ignacio Fernandez-Urien, Bruno Rosa, Neofytos P Papageorgiou, Jonathan A Leighton
BACKGROUND AND AIMS: This prospective, multicenter study evaluated small-bowel capsule endoscopy (CE) for the longitudinal assessment of mucosal inflammation in subjects with Crohn's disease (CD). METHODS: Subjects with known CD underwent clinical evaluation with ileocolonoscopy and CE at baseline and 6-month follow-up. Small-bowel patency was confirmed before CE at both time points. The Simple Endoscopic Score for CD (SES-CD) was used for ileocolonoscopy, and the Lewis score and the Capsule Endoscopy CD Endoscopic Index of Severity (CECDEIS) were used for CE...
August 4, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/30086159/cation-dependent-mannose-6-phosphate-receptor-expression-and-distribution-are-influenced-by-estradiol-in-mcf-7-breast-cancer-cells
#6
N Bannoud, F L Carvelli, M Troncoso, T Sartor, L M Vargas-Roig, M Sosa
Cancer cells secrete procathepsin D, and its secretion is enhanced by estradiol. Although alterations in the pro-enzyme intracellular transport have been reported, the mechanism by which it is secreted remains poorly understood. In this work, we have studied the influence of estradiol on the expression and distribution of the cation-dependent mannose-6-phosphate receptor (CD-MPR), which would be a key molecule to ensure the proper localization of the enzyme to lysosomes in breast cancer cells. Immunoblotting studies demonstrated that the expression of CD-MPR is higher in MCF-7 cells, as compared to other breast cancer and non-tumorigenic cells...
2018: PloS One
https://www.readbyqxmd.com/read/30086086/influence-of-inflammation-on-the-pharmacokinetics-of-perampanel
#7
Yoshiaki Yamamoto, Yukitoshi Takahashi, Asako Horino, Naotaka Usui, Takuji Nishida, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue
BACKGROUND: It is well-known that the pharmacokinetics of various drugs are influenced by inflammation. This study evaluated the relationship between C-reactive protein (CRP; an inflammation marker) and the pharmacokinetics of perampanel. METHODS: Among 111 patients who underwent measurement of both CRP and perampanel, 23 patients had a serum CRP level exceeding 1.5 mg/dL (CRP-positive). We compared the concentration/dose ratio (CD ratio) of perampanel in these 23 patients between the times when they were CRP-positive and CRP-negative...
August 1, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/30085339/markers-of-activated-inflammatory-cells-are-associated-with-disease-severity-and-intestinal-microbiota-in-adults-with-non%C3%A2-alcoholic-fatty-liver-disease
#8
Katherine J P Schwenger, Lina Chen, Adeline Chelliah, Hannah E Da Silva, Anastasia Teterina, Elena M Comelli, Amel Taibi, Bianca M Arendt, Sandra Fischer, Johane P Allard
Several mechanisms contribute to the pathogenesis of non‑alcoholic fatty liver disease (NAFLD). The intestinal microbiota (IM) and liver immune cells (LIC) may serve a role, but there has been no previous study assessing potential associations between IM and LIC. The aim of the present study was to investigate whether there are differences in LIC markers between patients with NAFLD and healthy controls (HC), and to determine whether these markers are associated with specific IM. The present prospective, cross‑sectional study examined a cohort of adults with liver biopsy‑confirmed NAFLD and HC...
October 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30082322/subsets-of-cd4-cd8-and-cd25-hi-lymphocytes-are-in-general-not-influenced-by-isolation-and-long-term-cryopreservation
#9
Andrea Tompa, Anette Nilsson-Bowers, Maria Faresjö
Several key factors can affect the outcome of immunological studies; isolation/cryopreservation can possibly alter T, B, NK, and T-regulatory (Treg) cell marker expression patterns. Blood samples from 50 blood donors supplemented with Na-heparin or K2 EDTA were handled within 4 and 24 h after blood sampling. PBMC were isolated with different density gradients. Flow cytometric analysis of intracellular and extracellular CD markers was performed on blood samples freshly isolated PBMC, and PBMC was thawed 6 and 12 mo post-cryopreservation for the purpose of identifying B, NK, Th, T-cytotoxic, and Treg cells...
August 6, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30078007/mirna-125b-regulates-osteogenic-differentiation-of-periodontal-ligament-cells-through-nkiras2-nf-%C3%AE%C2%BAb-pathway
#10
Nan Xue, Lin Qi, Guorong Zhang, Yang Zhang
BACKGROUND/AIMS: Osteogenesis of periodontal ligament cells (PDLCS) is essential for alveolar bone repair. Varieties of factors have been found involved in the regulation of PDLCs osteoblast differentiation. Aim of this study was to identify microRNA as a regulator of the os-teogenic differentiation of PDLCs. METHODS: The CD markers were analyzed by flow cytometry analysis. Osteoblast differentiation of PDLCs was induced by treatment with dexamethasone, β-glycerol phosphate and α-ascorbic acid...
August 3, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30064874/an-advanced-three-way-factor-analysis-model-sdabb-model-for-size-resolved-pm-source-apportionment-constrained-by-size-distribution-of-chemical-species-in-source-profiles
#11
Tong Liu, Yingze Tian, Qianqian Xue, Zhen Wei, Yong Qian, Yinchang Feng
Source samples including crustal dust, cement dust, coal combustion were sampled and ambient samples of PM2.5 and PM10 were synchronously collected in Hefei from April to December 2014. The size distributions of the markers in the measured source profiles were incorporated into ME-2 solution to develop a new method, called the SDABB model (an advanced ABB three-way factor analysis model incorporating size distribution information). The performance of this model was investigated using three-way synthetic and ambient dataset...
July 26, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/30057685/oxidative-stress-and-effect-of-treatment-on-the-oxidation-product-decomposition-processes-in-ibd
#12
Ewa Dudzińska, Magdalena Gryzinska, Katarzyna Ognik, Paulina Gil-Kulik, Janusz Kocki
Oxidative stress plays an important role in IBD because chronic intestinal inflammation is associated with the overproduction of reactive oxygen species (ROS) leading to oxidative stress, which has been implicated in IBD. Many lines of evidence suggest that IBD is associated with an imbalance between ROS and antioxidant activity which generates oxidative stress as the result of either ROS overproduction or a decrease in antioxidant activity. Our study was to evaluate the influence of oxidative stress and antioxidants on the course of the disease and treatment of IBD patients...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30056221/comparison-of-phenotypes-and-transcriptomes-of-mouse-skin-derived-precursors-and-dermal-mesenchymal-stem-cells
#13
Yiming Li, Xiaohua Li, Lidan Xiong, Jie Tang, Li Li
Both skin-derived precursors (SKPs) and dermal mesenchymal stem cells (dMSCs) are promising candidates for cellular therapy and regenerative medicine. To date the comparison of phenotypes and transcriptomes of mouse SKPs (mSKPs) and dMSCs has never been reported. Here we characterized and compared the biological properties and transcriptomes of mSKP and dMSCs from the same mouse dermis sample. Firstly, we analyzed mSKPs and dMSCs by use of immunocytochemistry, cell cycle analysis, and CD antigen expression...
July 20, 2018: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/30049191/immunohistochemically-detection-of-angiogenesis-in-oral-pre-cancerous-lesions-compared-with-oral-invasive-carcinomas
#14
Neda Kargahi, Nakisa Torabinia, Seyed Mohammad Razavi, Dana Tahririan, Hasan Kamani, Masoud Nazari
Background: Angiogenic activity is an important event in oral carcinogenesis. During transition of normal oral mucosa to different grades of dysplasia and to invasive carcinoma, significant increase of vascularity occurs. Angiogenesis can be determined by immunohistochemical assessment of several endothelial cell markers like Endogelin (CD 105), expressed in activated endothelial cells and associated with neovasculature, and the vascular endothelial growth factor (VEGF). This study was conducted to evaluate angiogenic activity in oral precancerous lesions compared with oral invasive carcinomas by immunohistochemical staining of VEGF and CD 105 proteins...
July 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/30048977/microbiota-quality-and-mitochondrial-activity-link-with-occurrence-of-muscle-cramps-in-hemodialysis-patients-using-citrate-dialysate-a-pilot-study
#15
Pierre-Yves Durand, Carole Nicco, Didier Serteyn, David Attaf, Marvin Edeas
BACKGROUND/AIMS: Hemodialysis-associated muscle cramp (HAMC) is a common complication under citrate dialysate (CD) occurring in 30% of cases. Our objectives were to assess the gut microbiota quality, mitochondrial activity, and to investigate their possible relationship with HAMC. METHODS: Ten end-stage renal disease patients (78.9 ± 2.1 years) treated by hemodialysis (HD) with CD were enrolled and then classified according to the frequency of HAMCs: "frequent HAMCs group" (n = 5) and "absence of HAMCs group" (n = 5)...
July 26, 2018: Blood Purification
https://www.readbyqxmd.com/read/30041303/assessment-of-potentially-toxic-metal-ptm-pollution-in-mangrove-habitats-using-biochemical-markers-a-case-study-on-avicennia-officinalis-l-in-and-around-sundarban-india
#16
Madhurima Bakshi, Somdeep Ghosh, Debarati Chakraborty, Sugata Hazra, Punarbasu Chaudhuri
Spatial distribution of potentially toxic metals (PTMs) and their accumulation in mangrove Avicennia officinalis L. were studied along 8 locations in and around Sundarban mangrove wetland, India. Among 8 locations, S3 (Chemaguri) and S5 (Ghushighata) showed higher concentration of PTMs (Cd, Cr, Cu, Ni, Pb, Zn) characterized by higher enrichment factors (3.45-10.03), geo-accumulation indices (0.04-1.22), contamination factors (1.14-3.51) and pollution load indices (1.3-1.45) indicating progressive deterioration of estuarine quality and considerable ecotoxicological risk...
August 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/30038095/c4d-as-a-marker-of-complement-activation-in-dermatomyositis-muscle-tissue
#17
Sundaram Challa, Megha S Uppin, Meena A Kannan, Liza Rajasekhar
Aim: To study C4d expression as a marker of complement activation in the diagnosis of dermatomyositis. Material and Methods: Muscle biopsies from patients diagnosed as definite dermatomyositis (10), nonspecific myositis associated with connective tissue disease (9), necrotizing autoimmune myositis (1), inclusion body myositis (1), and normal muscle (1) according to European Neuromuscular criteria 2004 were studied for C4d expression and capillary loss on CD 34 immunohistochemistry...
July 2018: Neurology India
https://www.readbyqxmd.com/read/30034529/fecal-calprotectin-for-detection-of-postoperative-endoscopic-recurrence-in-crohn-s-disease-systematic-review-and-meta-analysis
#18
Yuen Sau Tham, Diana E Yung, Shmuel Fay, Takayuki Yamamoto, Shomron Ben-Horin, Rami Eliakim, Anastasios Koulaouzidis, Uri Kopylov
Background: Anastomotic recurrence is frequent in patients with Crohn's disease (CD) following ileocecal resection. The degree of endoscopic recurrence, quantified by the Rutgeerts score (RS), correlates with risk of clinical and surgical recurrence. Several studies demonstrate the accuracy of fecal calprotectin (FC) for detection of endoscopic recurrence, however the optimal threshold FC value remains to be established. The aim of our meta-analysis was to evaluate the accuracy of common FC cut-offs for detection of endoscopic recurrence...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/30030096/suppression-of-ferroportin-expression-by-cadmium-stimulates-proliferation-emt-and-migration-in-triple-negative-breast-cancer-cells
#19
Zhongguo Shan, Zhengxi Wei, Zahir A Shaikh
Cadmium (Cd) has been linked to a variety of cancers, including breast cancer; however, the molecular mechanism of its carcinogenic activity is not fully understood. To this end, the present study investigated the roles of ferroportin (FPN), a prognostic marker of breast cancer, in Cd-induced stimulation of cell proliferation and cell migration. Triple-negative MDA-MB-231 cells were treated with 1-3 μM Cd. The cells exhibited significant reduction in FPN expression and concomitant increase in iron concentration...
July 17, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/30029674/functional-intraepithelial-lymphocyte-changes-in-inflammatory-bowel-disease-and-spondyloarthritis-have-disease-specific-correlations-with-intestinal-microbiota
#20
Emilie H Regner, Neha Ohri, Andrew Stahly, Mark E Gerich, Blair P Fennimore, Diana Ir, Widian K Jubair, Carsten Görg, Janet Siebert, Charles E Robertson, Liron Caplan, Daniel N Frank, Kristine A Kuhn
BACKGROUND: Dysbiosis occurs in spondyloarthritis (SpA) and inflammatory bowel disease (IBD), which is subdivided into Crohn's disease (CD) and ulcerative colitis (UC). The immunologic consequences of alterations in microbiota, however, have not been defined. Intraepithelial lymphocytes (IELs) are T cells within the intestinal epithelium that are in close contact with bacteria and are likely to be modulated by changes in microbiota. We examined differences in human gut-associated bacteria and tested correlation with functional changes in IELs in patients with axial SpA (axSpA), CD, or UC, and in controls...
July 20, 2018: Arthritis Research & Therapy
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