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https://www.readbyqxmd.com/read/30534505/management-of-the-lateral-breast
#1
Priyatma P Khincha, Jurga Pikturnaite, Ajay L Mahajan
Breast asymmetry is a common finding in developing adolescents. In select cases, there is maldevelopment of 1 or both breasts, which persists into adulthood and causes significant negative impact on life. Various surgical techniques (eg, breast augmentation/reduction) and nonsurgical techniques (eg, bras/gel inserts) are currently in practice to achieve breast symmetry. We describe a unique case of a young lady with Poland's syndrome, who presented with a lateralized right breast. We have used a V-Y advancement flap, along with a breast implant, to medialize the breast and achieve symmetry in contour and volume, followed by medialization of the nipple areolar complex...
October 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/30533339/breast-squamous-cell-carcinoma-following-breast-augmentation
#2
Yu M Zhou, Huma E Chaudhry, Amar Shah, Janna Andrews
Breast augmentation is the most common cosmetic surgery in the United States. Squamous cell carcinoma (SCC) of the breast raises suspicion of possibly metastatic origin. Here, we report an unusual case of implant-associated SCC of the breast post silicone gel breast implant. The patient is a 46-year-old female with SCC of the breast. She initially had silicone gel breast implantation for breast augmentation in 1995. She had multiple revisions due to swelling and hardening. In 2016, she underwent bilateral prosthesis explantation and bilateral capsulectomy...
October 3, 2018: Curēus
https://www.readbyqxmd.com/read/30498817/multiplexed-immunoassay-using-post-synthesis-functionalized-hydrogel-microparticles
#3
Hyun Jee Lee, Yoon Ho Roh, Hyeon Ung Kim, Sun Min Kim, Ki Wan Bong
In response to a growing demand for simultaneous detection of multiple proteins in a single sample, multiplex immunoassay platforms have emerged at the forefront of proteomic analysis. In particular, detections using graphically encoded hydrogel microparticles synthesized via flow lithography have received attention for integrating a hydrogel, a substrate that can provide enhanced kinetics and high loading capacity, into the bead-based multiplex platform. Currently, the method of microparticle functionalization involves copolymerization of antibodies with the gel during particle synthesis...
November 30, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/30497782/%C3%AE-sheet-to-%C3%AE-helix-conversion-and-thermal-stability-of-%C3%AE-galactosidase-encapsulated-in-a-nanoporous-silica-gel
#4
M Ines Burgos, Aylen Ochoa, María A Perillo
The effect on protein conformation and thermal stability was studied for β-Galactosidase (β-Gal) encapsulated in the nanopores of a silicate matrix (Eβ-Gal ). Circular dichroism spectra showed that, compared with the enzyme in buffer (Sβ-Gal ), Eβ-Gal exhibited a higher content of α-helix structure. Heating Eβ-Gal up to 75 °C caused a decrease in the content of β-sheet structure and additional augments on Eβ-Gal components attributed to helical content, instead of the generalized loss of the ellipticity signal observed with Sβ-Gal ...
November 26, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30496861/one-pot-synthesis-of-polysaccharide-based-hydrogel-embedded-gold-nanoparticles-physical-chemical-characterization-and-feasibility-for-large-scale-production
#5
Morgana Souza Marques, Κarine Modolon Zepon, Julia Maia Heckler, Fernando Dal Pont Morisso, Marcos Marques da Silva Paula, Luiz Alberto Κanis
In this study, polysaccharide-based hydrogel wound dressings containing in situ synthesized gold nanoparticles (AuNPs) were prepared by using a simple, fast and green protocol. The prepared hydrogels were characterized with UV-vis and infrared spectroscopy (FT-IR), and dynamic light scattering (DLS). The rheological and swelling properties and the feasibility to scale-up the wound dressing production from the lamination of the prepared hydrogel on non-woven fabric were also investigated. UV-vis spectra confirmed the AuNPs synthesis and the DLS results exhibited an increase in the size of AuNPs with increasing the initial Au3+ concentration...
November 26, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30483933/high-and-extra-high-profile-round-implants-in-breast-augmentation-guidelines-to-prevent-rippling-and-implant-edge-visibility
#6
Antonio Carlos Abramo, Marcio Scartozzoni, Thiago Walmsley Lucena, Romulo Grechi Sgarbi
BACKGROUND: Rippling and implant edge visibility after breast augmentation depends on several factors. Among the most relevant are breast soft tissue thickness, particularly the retroareolar mammary parenchyma, and implant profile. They were correlates to prevent these occurrences. METHODS: Thirty patients underwent breast augmentation through subfascial dissection involving the pectoralis, serratus, external oblique, and rectus abdominis fascias. The thickness of the retroareolar mammary parenchyma distributed patients into two groups...
November 27, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/30478264/complications-of-glans-penis-augmentation
#7
REVIEW
Sun Tae Ahn, Tae Il Kwak, Kwang Sung Park, Je Jong Kim, Du Geon Moon
Despite the controversy regarding penile augmentation (PA), glans penis augmentation (GPA) is used in penile reconstructive surgery in selected patients with small glans penis. Since 2003, injectable hyaluronic acid (HA) gel has been used for GPA. The attractiveness of HA gel fillers and interest in this technique have led to the use of other fillers for GPA, particularly irreversible fillers that improve the longevity of HA gels. Conversely, indirect glans augmentation via implantation of dermofat grafts or scaffolds between the corpus spongiosum and the distal tip of the corpus cavernosum is used to overcome poor longevity of the gel and glans surface undulation, which are the primary limitations of GPA using HA gel...
November 26, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/30474783/feasibility-of-a-novel-technique-using-3-dimensional-modeling-and-augmented-reality-for-access-during-percutaneous-nephrolithotomy-in-two-different-ex-vivo-models
#8
Murat Akand, Levent Civcik, Ahmet Buyukaslan, Emre Altintas, Erdinc Kocer, Mustafa Koplay, Tibet Erdogru
PURPOSE: We describe a novel technique that uses mathematical calculation software, 3-dimensional (3D) modeling and augmented reality (AR) technology for access during percutaneous nephrolithotomy (PCNL) and report our first preliminary results in two different ex-vivo models. METHODS: Novel software was created in order to calculate access point and angle by using pre-operative computed tomography (CT) obtained in 50 patients. Two scans, 27 s and 10 min after injection of contrast agent, were taken in prone PCNL position...
November 24, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30450677/autologous-platelet-rich-gel-for-facial-rejuvenation-and-wrinkle-amelioration-a-pilot-study
#9
Natalia Jiménez Gómez, Ander Pino Castresana, Gonzalo Segurado Miravalles, Mayte Truchuelo Díez, María Troya Estavillo, Eduardo Anitua Aldecoa, Pedro Jaén Olasolo
BACKGROUND: The demand for safe and minimally invasive soft tissue augmentation procedures has increased. Recently, a novel injectable gel based on the autologous platelet rich in growth factor (PRGF) technology has been developed to provide long-term shape and volume stability. It can be customized into low (LVG) or high viscosity (HVG) gel forms to meet different dermatological requirements. OBJECTIVES: The mechanical and biological properties of both gel forms have been evaluated...
November 18, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/30426537/programmed-cell-death-protein-4-deficiency-suppresses-foam-cell-formation-by-activating-autophagy-in-advanced-glycation-end-product-low-density-lipoprotein-induced-macrophages
#10
Shan Li, Guangdong Gao, Fuyun Wu, Dan Liu, Hongyan Zhao, Jing Ke, Ying Liu, Fei Li, Jian Li, Zongyun Chen, Zhiming Tang, Lei Bai, Jinxuan Zhang, Wei Zheng, Xin Chen
BACKGROUND: Advanced glycation end-product is a modified form of low-density lipoprotein (AGE-LDL) and accelerates atherosclerosis through undefined mechanisms. Programmed cell death protein 4 (PDCD4), a transcriptional regulator, plays an important role in the regulation of autophagy. The aim of the present study was to investigate the role of PDCD4 involved in AGE-LDL-induced foam cell formation. METHODS: The characterization of AGE-LDL was measured by the thiobarbituric assay and agarose gel electrophoresis in vitro...
November 13, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30399437/bioresponsive-peptide-polysaccharide-nanogels-a-versatile-delivery-system-to-augment-the-utility-of-bioactive-cargo
#11
Andrew W Simonson, Atip Lawanprasert, Tyler D P Goralski, Kenneth C Keiler, Scott H Medina
We report the design, synthesis and efficacy of a new class of gel-like nano-carrier, or 'nanogel', prepared via templated electrostatic assembly of anionic hyaluronic acid (HA) polysaccharides with the cationic peptide amphiphile poly-L-lysine (PLL). Small molecules and proteins present during nanogel assembly become directly encapsulated within the carrier and are precisely released by tuning the nanogel HA:PLL ratio to control particle swelling. Remarkably, nanogels exhibit versatile and complimentary mechanisms of cargo delivery depending on the biologic context...
November 3, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/30389603/anticancer-mechanism-of-troxerutin-via-targeting-nrf2-and-nf-%C3%AE%C2%BAb-signalling-pathways-in-hepatocarcinoma-cell-line
#12
Nisha Susan Thomas, Kiran George, Athavan Alias Anand Selvam
Troxerutin (TX), a bioflavonoid widely present in various fruits and vegetables, has shown to exhibit numerous pharmacological properties including anti-neoplastic and anti-cancer activities. Nrf2 and NF-κB are the key transcription factors that regulate oxidative stress and inflammation, therefore we assessed whether TX modulate these pathways and its downstream proteins in HuH-7 hepatocarcinoma cells. TX induced apoptotic cellular and nuclear changes were examined by fluorescence staining techniques, agarose gel electrophoresis and flow cytometry...
October 30, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/30383228/reoperation-rate-after-primary-augmentation-with-smooth-textured-high-fill-cohesive-round-breast-implants-ranbi-i-study
#13
Julie Khanna, Mathew Mosher, Paul Whidden, Sébastien Nguyen, Diego Garzon, Meetu Bhogal
Background: Reoperation after primary breast augmentation remains an important clinical issue. Objective: Evaluate incidence and causes of reoperation in patients who underwent primary augmentation. Methods: This retrospective, noninterventional study conducted at 16 Canadian sites reviewed medical records and subject-completed questionnaires of women who underwent primary breast augmentation with smooth or textured Natrelle® Inspira® implants containing TruForm 1 or TruForm 2 gel...
November 1, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/30368387/a-novel-gel-patch-for-minimally-invasive-repair-of-tympanic-membrane-perforations
#14
Benjamin J Rubinstein, Jesse D Ranney, Parastoo Khoshakhlagh, Barry Strasnick, Elaine L Horn-Ranney
OBJECTIVE: Evaluate the efficacy of a photocrosslinkable gel patch for repairing tympanic membrane (TM) perforations using a minimally invasive procedure. METHODS: 38 adult male chinchillas underwent bilateral TM perforation via CO2 laser (n = 76 TMs). Eight weeks post-perforation induction, either a gel patch (n = 26) or EpiDisc (n = 12) was applied to the perforation through the ear canal. Perforation margins were not abraded prior to gel patch application in order to make the procedure minimally invasive...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30288565/complication-of-ruptured-poly-implant-proth%C3%A3-se-%C3%A2-breast-implants-combined-with-aquafilling-%C3%A2-gel-injection-a-case-report-and-literature-review
#15
Jaewoo Kim, Hak Chang, Ji-Ung Park
INTRODUCTION: We describe the first case of a patient who received AQUAfilling® gel (Biomedica, Prague, Czech Republic) after augmentation with Poly Implant Prothèse® (PIP) breast implants and later developed breast deformity with bilateral implant rupture. CASE REPORT: A 49-year-old Korean female patient who received breast augmentation with PIP implants 18 years ago and subsequent insertion of AQUAfilling® gel 1 year ago visited our center with a chief complaint of pain and decreased implant sizes in both breasts...
October 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/30287361/hyaluronic-acid-a-promising-skin-rejuvenating-biomedicine-a-review-of-recent-updates-and-pre-clinical-and-clinical-investigations-on-cosmetic-and-nutricosmetic-effects
#16
REVIEW
Syed Nasir Abbas Bukhari, Nur Liyana Roswandi, Muhammad Waqas, Haroon Habib, Fahad Hussain, Shahzeb Khan, Muhammad Sohail, Nor Amlizan Ramli, Hnin Ei Thu, Zahid Hussain
Hyaluronic acid (HA) plays multifaceted role in regulating the various biological processes such as skin repairmen, diagnosis of cancer, wound healing, tissue regeneration, anti-inflammatory, and immunomodulation. Owing to its remarkable biomedical and tissue regeneration potential, HA has been numerously employed as one of the imperative components of the cosmetic and nutricosmetic products. The present review aims to summarize and critically appraise recent developments and clinical investigations on cosmetic and nutricosmetic efficacy of HA for skin rejuvenation...
December 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30284941/in-vitro-investigation-into-the-forces-involved-during-lipofilling
#17
Laura J Leslie, Yezen Sheena, Duncan Et Shepherd, Amir Ismail, Stephen N Kukureka, Vik Vijh
Breast augmentation using implants is the most common aesthetic and reconstructive breast surgical procedure. Complications such as implant rupture maybe related to surgical technique and damage to the implant. Autologous fat transfer (lipofilling) using metallic cannulae has become a standard adjunctive, yet there is little evidence on lipofilling safety in the presence of implants. The aims of this study are to verify the effects of different cannulae and to quantify the forces applied by surgeons during lipofilling...
November 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/30252757/clinical-results-on-innovation-in-breast-implant-design
#18
Edward I Chang, Dennis C Hammond
Breast implants have been shadowed in controversy since their introduction to the market; however, they represent a multi-million dollar industry and play a critical role both for cosmetic augmentation and enhancement and for reconstruction following treatment for cancer. With advancements in technology, breast implants have evolved tremendously over the years. Further, with the cessation of the FDA implemented moratorium on silicone, the use of silicone implants has grown exponentially over the years. Novel designs in the outer shell, breast implant fill particularly the cohesivity of the silicone gel, texturing of the outer shell, and the shape and projection of breast implants have produced a broad array of implants that can be employed by plastic and reconstructive surgeons to maximize outcomes for patients...
October 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/30252754/breast-implant-engineering-and-performance
#19
Khashayar Mohebali, Roger N Wixtrom
The engineering of breast implants for both augmentation and reconstruction is centered on facilitating optimal aesthetic results pleasing to the patient, while minimizing both short- and long-term complications. Some of the key individual design elements that have been the primary focus over time have included gel cohesivity, shell thickness, shell surface, and implant gel fill. A review of these separate elements points to the potential benefits of increased focus on a combined overall performance perspective for engineering of new implants as exemplified in the recently introduced MemoryGel Xtra Breast Implants...
October 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/30235049/influence-of-testosterone-substitution-on-glycemic-control-and-endothelial-markers-in-men-with-newly-diagnosed-functional-hypogonadism-and-type-2-diabetes-mellitus-a-randomized-controlled-trial
#20
Irina Khripun, Sergey Vorobyev, Igor Belousov, Michel Kogan, Michael Zitzmann
Effects of testosterone (T) on the cardiovascular system of men remain controversial. The impact of T-replacement therapy (TRT) in men with functional hypogonadism and type 2 diabetes mellitus (T2DM) has to be elucidated. This study included 80 men (mean age 51.5 ± 6.3 years) with newly diagnosed T2DM (according to ADA criteria) and functional hypogonadism (according to EAU criteria). Randomization: Group1 (n = 40): TRT using 1%-transdermal T-gel (50 mg/day), Group2 (n = 40) no TRT (controls)...
September 20, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
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