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Gel augmentation

Hyeong Guk Jeong, Sun Tae Ahn, Jong Wook Kim, Kyung Keun Seo, Dong Soo Lee, Hong Sun Uh, Je Jong Kim, Du Geon Moon
INTRODUCTION: Glans penis augmentation (GPA) using hyaluronic acid (HA) gel has been developed for treating premature ejaculation (PE) with penile hypersensitivity. The injected HA filler creates a barrier that reduces the tactile stimuli to the hypersensitive dorsal nerve. Although the HA filler is biodegradable and is believed to not cause permanent loss of sexual function, the current International Society for Sexual Medicine guideline for PE does not recommend this procedure owing to concerns regarding sexual dysfunction...
August 2, 2018: Sexual Medicine
Reza Jafari, Naime Majidi Zolbanin, Jafar Majidi, Fatemeh Atyabi, Mehdi Yousefi, Farhad Jadidi-Niaragh, Leili Aghebati-Maleki, Dariush Shanehbandi, Mohammad-Sadegh Soltani Zangbar, Houshang Rafatpanah
Background: Targeted co-delivery of siRNA and a chemotherapeutic drug is an attractive approach to cancer drug design and treatment. This study was carried out to design an anti-Mucin 1 aptamer (Apt)-conjugated chitosan nanoparticle (NP) for targeted co-delivery of insulin-like growth factor receptor 1 (IGF-1R) siRNA and docetaxel (DTX) to SKBR3 cells. Methods: Characterization of nano-drugs, cellular uptake of NPs, cell viability, and gene expression studies were evaluated based on metastatic breast cancer cells...
July 25, 2018: Iranian Biomedical Journal
Charles Randquist, Yong Chen Por, Vincent Yeow, Joy Maglambayan, Susan Simonyi
Background: This analysis presents patient-reported outcomes of breast augmentation procedures performed in Singapore using an inframammary fold incision and the "5 Ps" best practice principles for breast augmentation. These data are the first of their kind in Southeast Asian patients. Methods: Through a retrospective chart review, patients who underwent primary breast augmentation with anatomical form-stable silicone gel breast implants using an inframammary fold incision were followed for ≥6 months postoperatively...
July 2018: Archives of Plastic Surgery
Adrienne E Campbell-Washburn, Toby Rogers, Annette M Stine, Jaffar M Khan, Rajiv Ramasawmy, William H Schenke, Delaney R McGuirt, Jonathan R Mazal, Laurie P Grant, Elena K Grant, Daniel A Herzka, Robert J Lederman
BACKGROUND: Cardiovascular magnetic resonance (CMR) fluoroscopy allows for simultaneous measurement of cardiac function, flow and chamber pressure during diagnostic heart catheterization. To date, commercial metallic guidewires were considered contraindicated during CMR fluoroscopy due to concerns over radiofrequency (RF)-induced heating. The inability to use metallic guidewires hampers catheter navigation in patients with challenging anatomy. Here we use low specific absorption rate (SAR) imaging from gradient echo spiral acquisitions and a commercial nitinol guidewire for CMR fluoroscopy right heart catheterization in patients...
June 21, 2018: Journal of Cardiovascular Magnetic Resonance
Kamran Efendioglu, Ersin Aksam, Berrak Aksam, Murat Tuzuner, Hakan Gence
BACKGROUND: Breast ptosis is an inevitable consequence of gravity and time. Every breast tends to become ptotic in different shapes and degrees. Many surgical techniques were described to solve this problematic issue. The aim of this article is to describe a mastopexy technique used for grades 1 to 2 ptosis, "tuck-in" mastopexy technique. METHODS: Keyhole pattern was used for skin markings. All the planned skin excision areas were de-epithelialized. Breast mound was elevated as a 1-piece flap with extensive subglandular dissection...
June 19, 2018: Annals of Plastic Surgery
Aaron C Van Slyke, Michael Carr, Nicholas J Carr
BACKGROUND: Augmentation mammoplasty is the most common aesthetic procedure. Textured implants control implant position and have improved capsular contracture rates; however, the impact of texturing on longevity and clinical findings at explantation is unclear. METHODS: All cases of explantation between January 2005 - April 2017 from an aesthetic practice were reviewed retrospectively. Patient demographics, implant characteristics, time-to-explantation, and clinical presentation and intraoperative findings at explantation were analyzed...
June 4, 2018: Plastic and Reconstructive Surgery
Kevin Gillmann, Kaweh Mansouri, Giorgio E Bravetti, André Mermoud
INTRODUCTION: In recent years microinvasive glaucoma surgery has risen in popularity. Among microinvasive glaucoma surgery options is the XEN gel stent (Allergan Plc, Dublin, Ireland), a 45 μm wide ab-interno microstent. It has proven effective in lowering intraocular pressure (IOP) with low complication rates. However, XEN gel stents can become obstructed and cause postoperative rise in IOP. The causes and predicting factors for such obstructions still requires further research. CASE REPORT: We describe the case of a 69-year-old male patient, with traumatic glaucoma and chronic intraocular inflammation showed by laser flare photometry, following childhood trauma and anterior segment surgery...
August 2018: Journal of Glaucoma
Ayumi Kida, Takayuki Ikeda, Hiroki Seto, Yasuhiro Iida
 Only 4 classes of antifungal agents comprising 9 compounds are effective against deep mycosis in Japan, and it has been difficult to develop new antifungal specific agents. Micafungin, which has been used as an antifungal agent since 2002, inhibits β-1,3-glucan synthesis in fungal cell walls, thereby killing yeast and filamentous fungi with no septum. In this study, we constructed a pYES2-BGL2 vector to overexpress β-1,3-glucanase (BGL2) in yeast (Saccharomyces cerevisiae INVSc1) and evaluated the synergy between BGL2 overexpression and conventional antifungal agents...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
D M Varma, H A Lin, R G Long, G T Gold, A C Hecht, J C Iatridis, S B Nicoll
Back and neck pain are commonly associated with intervertebral disc (IVD) degeneration. Structural augmentation of diseased nucleus pulposus (NP) tissue with biomaterials could restore degeneration-related IVD height loss and degraded biomechanical behaviors; however, effective NP replacement biomaterials are not commercially available. This study developed a novel, crosslinked, dual-polymer network (DPN) hydrogel comprised of methacrylated carboxymethylcellulose (CMC) and methylcellulose (MC), and used in vitro, in situ and in vivo testing to assess its efficacy as an injectable, in situ gelling, biocompatible material that matches native NP properties and restores IVD biomechanical behaviors...
May 30, 2018: European Cells & Materials
Yao Yao, Junrong Cai, Pan Zhang, Yunjun Liao, Yi Yuan, Ziqing Dong, Feng Lu
BACKGROUND: The clinical outcomes of fat grafting vary and are technique-dependent. Stromal vascular fraction (SVF) gel is a novel, mechanically processed fat product with high concentrations of adipose tissue-derived stem cells and other SVF cells. This study evaluated the volumization and rejuvenation effects of SVF-gel. OBJECTIVE: This study evaluated the volumization and rejuvenation effects of SVF-gel. METHODS: This retrospective, single-center study included 126 patients who underwent SVF-gel grafting and 78 who underwent conventional lipoinjection for various indications from March 2015 to February 2017...
May 16, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Monika Dhote, Anil Kumar, Anjana Jajoo, Asha Juwarkar
A 90 days greenhouse experiment was conducted for evaluation of soil microbial diversity in different treatments of rhizospheric and nonrhizospheric oil sludge contaminated soil. Various pot treatments (T1-T5) were as follows: 2% oil sludge contaminated soil was considered as control (T1); augmentation of control with preadapted microbial consortium was T2; addition of Vetiver zizanioide to control was T3; bioaugmentation of control along with V. zizanioide was T4; and bioaugmentation with V. zizanioide and bulking agent was T5...
July 3, 2018: International Journal of Phytoremediation
Rikiya Baba, Tomohiro Onodera, Masatake Matsuoka, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Kentaro Homan, Norimasa Iwasaki
BACKGROUND: The optimal treatment for a medium- or large-sized cartilage lesion is still controversial. Since an ultrapurified alginate (UPAL) gel enhances cartilage repair in animal models, this material is expected to improve the efficacy of the current treatment strategies for cartilage lesions. HYPOTHESIS: The bone marrow stimulation technique (BMST) augmented by UPAL gel can induce hyaline-like cartilage repair. STUDY DESIGN: Controlled laboratory study...
July 2018: American Journal of Sports Medicine
Sarah Bouhabel, Christopher J Hartnick
INTRODUCTION: The objective of this study was to poll pediatric otolaryngologists with a special interest in pediatric laryngology on their experience with injection medialization laryngoplasty (IML), thyroplasty, and reinnervation procedures in order to reflect on changing clinical practices. METHOD: A 10-items questionnaire was designed to inquire about current management practices in the treatment of symptomatic UVFI. The 59 members of an ASPO pediatric laryngology working group received the anonymous online survey...
June 2018: International Journal of Pediatric Otorhinolaryngology
Valentin P Yakubenko, Kui Cui, Christopher L Ardell, Kathleen E Brown, Xiaoxia Z West, Detao Gao, Samantha Stefl, Robert G Salomon, Eugene A Podrez, Tatiana V Byzova
Early stages of inflammation are characterized by extensive oxidative insult by recruited and activated neutrophils. Secretion of peroxidases, including the main enzyme, myeloperoxidase, leads to the generation of reactive oxygen species. We show that this oxidative insult leads to polyunsaturated fatty acid (eg, docosahexaenoate), oxidation, and accumulation of its product 2-(ω-carboxyethyl)pyrrole (CEP), which, in turn, is capable of protein modifications. In vivo CEP is generated predominantly at the inflammatory sites in macrophage-rich areas...
July 5, 2018: Blood
Chih-Long Chen, Han-Wen Tien, Chia-Hui Chuang, Ying-Chieh Chen
Restoring adequate blood supply is essential to the success of bone repair and augmentation procedures in craniofacial surgery. Nevertheless, the manner by which the incorporation of collagen gels (which can potentially induce angiogenesis), particulated deproteinized bovine bone grafts, or a combination of both can accelerate or delay bone regeneration in a clinical setting remains controversial. The objective of this study was to evaluate radiographically and histologically the capacity and functionality of particulated bone grafts and collagen gels on bone ossification and soft tissue formation in a rabbit calvarial defect...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Pallvi Bragta, Rupinder Kaur Sidhu, Kiran Jyoti, Ashish Baldi, Upendra Kumar Jain, Ramesh Chandra, Jitender Madan
BACKGROUND AND OBJECTIVE: In a phase II clinical trial, carboplatin (CBDCA) displayed the response rate of 19% equivalent to dacarbazine in the treatment of malignant melanoma. However, besides desirable therapeutic profile, intravenous (i.v) administration of CBDCA delivers a subtherapeutic concentration at the target site. This entails administration of CBDCA through an alternate route by using nanovectors to achieve therapeutic efficacy in the treatment of melanoma. METHODS AND RESULTS: Carboplatin loaded poly(ε-caprolactone) nanoparticles (CBDCA-PCL-NPs) were formulated and amalgamated with chitosan-β-glycerophosphate gel (CBDCA-PCL-NPs-Gel) for intratumoral (i...
June 1, 2018: Colloids and Surfaces. B, Biointerfaces
Mahmoud E Soliman, Enas Elmowafy, Luca Casettari, Cameron Alexander
The aim of this work was to obtain an intranasal delivery system with improved mechanical and mucoadhesive properties that could provide prolonged retention time for the delivery of risedronate (RS). For this, novel in situ forming gels comprising thermo-responsive star-shaped polymers, utilizing either polyethylene glycol methyl ether (PEGMA-ME 188, Mn 188) or polyethylene glycol ethyl ether (PEGMA-EE 246, Mn 246), with polyethylene glycol methyl ether (PEGMA-ME 475, Mn 475), were synthesized and characterized...
May 30, 2018: International Journal of Pharmaceutics
Michael R Schwartz, Melinda J Haws, Ginny Phillips
BACKGROUND: Board-certified plastic surgeons utilizing the Sientra 207 Highly Cohesive Gel breast implants provided their initial satisfaction with usage and postoperative results on primary and revision augmentation patients, and study participants provided their satisfaction with surgical result. METHODS: Up to 15 participating investigators at institutional review board-approved sites enrolled up to 180 women who received Sientra 207 implants for primary augmentation or revision augmentation procedures...
April 2018: Plastic and Reconstructive Surgery
W Grant Stevens, M Bradley Calobrace, Kaveh Alizadeh, Kamakshi R Zeidler, Jennifer L Harrington, Rosalyn C d'Incelli
BACKGROUND: In March 2012, the United States Food and Drug Administration approved Sientra's application for premarket approval of its portfolio of round and shaped silicone gel breast implants based on data from the largest silicone gel breast implant study to date. This article presents the results of Sientra's Core Study at the conclusion of 10 years. METHODS: The Sientra Core Study was a 10-year, open-label, prospective, multicenter clinical study designed to assess the safety and effectiveness of Sientra's breast implants in augmentation and reconstruction...
April 2018: Plastic and Reconstructive Surgery
Xiaolong Liu, Yiran Xia, Lulu Liu, Dongmei Zhang, Zhaosheng Hou
The purpose of this study is to offer a novel kind of polyurethane with improved surface blood compatibility for long-term implant biomaterials. In this work, the aliphatic poly(ester-urethane) (PEU) with uniform-size hard segments was prepared and the PEU surface was grafted with hydrophilic poly(ethylene glycol) (PEG). The PEU was obtained by chain-extension of poly(ɛ-caprolactone) (PCL) with isocyanate-terminated urethane triblock. Free amino groups were introduced onto the surface of PEU film via aminolysis with hexamethylenediamine, and then the NH2 -grafted PEU surfaces (PEU-NH2 ) were reacted with isocyanate-terminated monomethoxyl PEG (MPEG-NCO) to obtain the PEG-grafted PEU surfaces (PEU-PEG)...
May 2018: Journal of Biomaterials Applications
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