Jacqueline Chua, Mihai Bostan, Chi Li, Yin Ci Sim, Inna Bujor, Damon Wong, Bingyao Tan, Xinwen Yao, Florian Schwarzhans, Gerhard Garhöfer, Georg Fischer, Clemens Vass, Cristina Tiu, Ruxandra Pirvulescu, Alina Popa-Cherecheanu, Leopold Schmetterer
BACKGROUND: Optical coherence tomography (OCT) is a retinal imaging system that may improve the diagnosis of multiple sclerosis (MS) persons, but the evidence is currently equivocal. To assess whether compensating the peripapillary retinal nerve fiber layer (pRNFL) thickness for ocular anatomical features as well as the combination with macular layers can improve the capability of OCT in differentiating non-optic neuritis eyes of relapsing-remitting MS patients from healthy controls. METHODS: 74 MS participants (n = 129 eyes) and 84 age- and sex-matched healthy controls (n = 149 eyes) were enrolled...
2022: NeuroImage: Clinical