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Compensations in nerve injury

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https://www.readbyqxmd.com/read/28806496/anterior-superior-alveolar-nerve-injury-after-extended-endoscopic-medial-maxillectomy-a-preclinical-study-to-predict-neurological-morbidity
#1
Alberto Schreiber, Davide Mattavelli, Marco Ferrari, Vittorio Rampinelli, Davide Lancini, Marco Ravanelli, Giacomo Bertazzoni, Luigi Fabrizio Rodella, Barbara Buffoli, Francesco Doglietto, Piero Nicolai
BACKGROUND: Endoscopic medial maxillectomies (EMMs) are used to optimize exposure of the maxillary sinus and retromaxillary areas. Although in type D EMM (Sturmann-Canfield procedure) the anterior superior alveolar nerve (ASAN) is always at risk of injury, only 29% of patients complained of alveolar process and dental anesthesia. The purpose of this anatomical study is to assess the neural anastomotic network of the ASAN (ASAN-NAN) and describe different extensions of type D EMMs in a preclinical setting...
August 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28673825/the-medico-legal-landscape-of-spine-surgery-how-do-surgeons-fare
#2
Melvin C Makhni, Paul J Park, Jesus Jimenez, Comron S Saifi, Jon-Michael Caldwell, Alex Ha, Bianca Figueroa-Santana, Ronald A Lehman, Mark Weidenbaum
BACKGROUND CONTEXT: Due to the limited and confidential nature of most legal data, scarce literature is available to physicians about reasons for litigation in spine surgery. In order to optimally compensate patients while protecting physicians, further understanding of the medico-legal landscape is needed for high-risk procedures such as spine surgery. Based on these, surgeons can explore ways to better protect both their patients and themselves. PURPOSE: To characterize the current medico-legal environment of spine surgery by analyzing a recent dataset of malpractice litigation...
June 30, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28581273/clinical-features-of-post-vaccination-guillain-barr%C3%A3-syndrome-gbs-in-korea
#3
Yong Shik Park, Keon Joo Lee, Seung Woo Kim, Kyung Min Kim, Bum Chun Suh
Guillain-Barré syndrome (GBS) is the most common immune-mediated polyradiculoneuropathy and it is also the most commonly reported severe adverse event following immunization in adults. To evaluate the results of clinical and laboratory features of GBS after vaccination in Korea, we analyzed the claims-based data from 2002 to 2014 using materials collected for the Advisory Committee Vaccination Injury Compensation (ACVIC) meeting including, clinical features, nerve conduction studies (NCSs), cerebrospinal fluid (CSF) profiles, treatment, and outcomes...
July 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28394696/pharmacology-pharmacokinetics-and-metabolism-of-the-dna-decoy-ayx1-for-the-prevention-of-acute-and-chronic-post-surgical-pain
#4
Julien Mamet, Scott Harris, Michael Klukinov, David C Yeomans, Renee R Donahue, Brad K Taylor, Kelly Eddinger, Tony Yaksh, Donald C Manning
Background AYX1 is an unmodified DNA-decoy designed to reduce acute post-surgical pain and its chronification with a single intrathecal dose at the time of surgery. AYX1 inhibits the transcription factor early growth response protein 1, which is transiently induced at the time of injury and triggers gene regulation in the dorsal root ganglia and spinal cord that leads to long-term sensitization and pain. This work characterizes the AYX1 dose-response profile in rats and the link to AYX1 pharmacokinetics and metabolism in the cerebrospinal fluid, dorsal root ganglia, and spinal cord...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28386211/on-the-auditory-proprioception-substitution-hypothesis-movement-sonification-in-two-deafferented-subjects-learning-to-write-new-characters
#5
Jérémy Danna, Jean-Luc Velay
The aim of this study was to evaluate the compensatory effects of real-time auditory feedback on two proprioceptively deafferented subjects. The real-time auditory feedback was based on a movement sonification approach, consisting of translating some movement variables into synthetic sounds to make them audible. The two deafferented subjects and 16 age-matched control participants were asked to learn four new characters. The characters were learned under two different conditions, one without sonification and one with sonification, respecting a within-subject protocol...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28344819/olfaction-as-a-soldier-a-review-of-the-physiology-and-its-present-and-future-use-in-the-military
#6
REVIEW
Palaniappan Ganesh Nagappan, Somasundram Subramaniam, De-Yun Wang
Olfaction is one of our 5 main qualitative sensory abilities. In this review, we have examined the physiology of olfaction from the olfactory receptor to the brain. Through analyzing the physiology of olfaction, we have found that the biochemistry of olfactory nerve stimulation is unique from that of other similar pathways. Upon receiving large amounts of input from the olfactory nerve, the olfactory bulb, followed by several layers of centrifugal and centripetal processing in the brain, has to sort the information from the input as well as integrate it with other inputs from the brain to develop a coherent understanding of the input...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28293524/effect-of-axonal-trauma-on-nerve-regeneration-in-side-to-side-neurorrhaphy-an-experimental-study
#7
Henrikki Rönkkö, Harry Göransson, Hanna-Stiina Taskinen, Pasi Paavilainen, Tero Vahlberg, Matias Röyttä
BACKGROUND: Side-to-side (STS) neurorrhaphy can be performed distally to ensure timely end-organ innervation. It leaves the distal end of the injured nerve intact for further reconstruction. Despite encouraging clinical results, only few experimental studies have been published to enhance the regeneration results of the procedure. We examined the influence of different size epineural windows and degree of axonal injury of STS repair on nerve regeneration and donor nerve morbidity. METHODS: Three clinically relevant repair techniques of the transected common peroneal nerve (CPN) were compared...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28250799/inhibition-of-cell-proliferation-does-not-slow-down-echinoderm-neural-regeneration
#8
Vladimir S Mashanov, Olga R Zueva, José E García-Arrarás
BACKGROUND: Regeneration of the damaged central nervous system is one of the most interesting post-embryonic developmental phenomena. Two distinct cellular events have been implicated in supplying regenerative neurogenesis with cellular material - generation of new cells through cell proliferation and recruitment of already existing cells through cell migration. The relative contribution and importance of these two mechanisms is often unknown. METHODS: Here, we use the regenerating radial nerve cord (RNC) of the echinoderm Holothuria glaberrima as a model of extensive post-traumatic neurogenesis in the deuterostome central nervous system...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/27816609/surgical-exploration-of-hand-wounds-in-the-emergency-room-preliminary-study-of-80-personal-injury-claims
#9
J Mouton, H Houdre, R Beccari, N Tarissi, M Autran, I Auquit-Auckbur
BACKGROUND: The SHAM Insurance Company in Lyon, France, estimated that inadequate hand wound exploration in the emergency room (ER) accounted for 10% of all ER-related personal injury claims in 2013. The objective of this study was to conduct a critical analysis of 80 claims that were related to hand wound management in the ER and led to compensation by SHAM. MATERIAL AND METHODS: Eighty claims filed between 2007 and 2010 were anonymised then included into the study...
December 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27570828/recruitment-of-polysynaptic-connections-underlies-functional-recovery-of-a-neural-circuit-after-lesion
#10
Akira Sakurai, Arianna N Tamvacakis, Paul S Katz
The recruitment of additional neurons to neural circuits often occurs in accordance with changing functional demands. Here we found that synaptic recruitment plays a key role in functional recovery after neural injury. Disconnection of a brain commissure in the nudibranch mollusc, Tritonia diomedea, impairs swimming behavior by eliminating particular synapses in the central pattern generator (CPG) underlying the rhythmic swim motor pattern. However, the CPG functionally recovers within a day after the lesion...
July 2016: ENeuro
https://www.readbyqxmd.com/read/27511213/malpractice-claims-related-to-tooth-extractions
#11
Sanna Koskela, Anni Suomalainen, Satu Apajalahti, Irja Ventä
OBJECTIVE: The aim of this study was to analyze malpractice claims related to tooth extractions in order to identify areas requiring emphasis and eventually to reduce the number of complications. MATERIAL AND METHODS: We compiled a file of all malpractice claims related to tooth extractions (EBA code) between 1997 and 2010 from the Finnish Patient Insurance Centre. We then examined the data with respect to date, tooth, surgery, injury diagnosis, and the authority's decision on the case...
August 10, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27489364/responses-of-non-eye-movement-central-vestibular-neurons-to-sinusoidal-yaw-rotation-in-compensated-macaques-after-unilateral-semicircular-canal-plugging
#12
Shawn D Newlands, Min Wei, David Morgan, Hongge Luan
After vestibular labyrinth injury, behavioral measures of vestibular performance recover to variable degrees (vestibular compensation). Central neuronal responses after unilateral labyrinthectomy (UL), which eliminates both afferent resting activity and sensitivity to movement, have been well-studied. However, unilateral semicircular canal plugging (UCP), which attenuates angular-velocity detection while leaving afferent resting activity intact, has not been extensively studied. The current study reports response properties of yaw-sensitive non-eye-movement rhesus macaque vestibular neurons after compensation from UCP...
October 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27062353/hip-arthroplasty-malpractice-claims-in-the-netherlands-closed-claim-study-2000-2012
#13
Imme Zengerink, Max Reijman, Nina M C Mathijssen, Manon P Eikens-Jansen, P Koen Bos
BACKGROUND: A total hip arthroplasty (THA) is a successful and reliable operation with few complications. These complications however, do form a potential source for compensation claims. In the Netherlands, there are no studies available concerning filed claims after THA. The aim of this study was to determine the incidence of claims related to THAs in the Netherlands and the reasons to claim, which claims lead to compensation, the costs involved for the insurer, and the demographics of the claimants...
September 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/26807789/emerging-technologies-with-potential-for-objectively-evaluating-speech-recognition-skills
#14
REVIEW
Vishakha Waman Rawool
Work-related exposure to noise and other ototoxins can cause damage to the cochlea, synapses between the inner hair cells, the auditory nerve fibers, and higher auditory pathways, leading to difficulties in recognizing speech. Procedures designed to determine speech recognition scores (SRS) in an objective manner can be helpful in disability compensation cases where the worker claims to have poor speech perception due to exposure to noise or ototoxins. Such measures can also be helpful in determining SRS in individuals who cannot provide reliable responses to speech stimuli, including patients with Alzheimer's disease, traumatic brain injuries, and infants with and without hearing loss...
2016: International Journal of Audiology
https://www.readbyqxmd.com/read/26719418/palmitoylation-controls-dlk-localization-interactions-and-activity-to-ensure-effective-axonal-injury-signaling
#15
Sabrina M Holland, Kaitlin M Collura, Andrea Ketschek, Kentaro Noma, Toby A Ferguson, Yishi Jin, Gianluca Gallo, Gareth M Thomas
Dual leucine-zipper kinase (DLK) is critical for axon-to-soma retrograde signaling following nerve injury. However, it is unknown how DLK, a predicted soluble kinase, conveys long-distance signals and why homologous kinases cannot compensate for loss of DLK. Here, we report that DLK, but not homologous kinases, is palmitoylated at a conserved site adjacent to its kinase domain. Using short-hairpin RNA knockdown/rescue, we find that palmitoylation is critical for DLK-dependent retrograde signaling in sensory axons...
January 19, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26709570/a-new-rerouting-technique-for-the-extensor-pollicis-longus-in-palliative-treatment-for-wrist-and-finger-extension-paralysis-resulting-from-radial-nerve-and-c5c6c7-root-injury
#16
Jennifer Laravine, Adeline Cambon-Binder, Zoubir Belkheyar
Wrist and finger extension paralysis is a consequence of an injury to the radial nerve or the C5C6C7 roots. Despite these 2 different levels of lesions, palliative treatment for this type of paralysis depends on the same tendon transfers. A large majority of the patients are able to compensate for a deficiency of the extension of the wrist and fingers. However, a deficiency in the opening of the first web space, which could be responsible for transfers to the abductor pollicis longus, the extensor pollicis brevis, and the extensor pollicis longus (EPL), frequently exists...
March 2016: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/26674887/a-cadaveric-study-of-the-communication-patterns-between-the-buccal-trunks-of-the-facial-nerve-and-the-infraorbital-nerve-in-the-midface
#17
Tanvaa Tansatit, Piyaporn Phanchart, Dawinee Chinnawong, Prawit Apinuntrum, Thavorn Phetudom, Yasmina M E Sahraoui
Most nerve communications reported in the literature were found between the terminal branches. This study aimed to clarify and classify patterns of proximal communications between the buccal branches (BN) of the facial nerve and the infraorbital nerve (ION).The superficial musculoaponeurotic system protects any communication sites from conventional dissections. Based on this limitation, the soft tissues of each face were peeled off the facial skull and the facial turn-down flap specimens were dissected from the periosteal view...
January 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/26495080/review-of-medical-dispute-cases-in-the-pain-management-in-korea-a-medical-malpractice-liability-insurance-database-study
#18
Yeon Dong Kim, Hyun Seog Moon
BACKGROUND: Pain medicine often requires medico-legal involvement, even though diagnosis and treatments have improved considerably. Multiple guidelines for pain physicians contain many recommendations regarding interventional treatment. Unfortunately, no definite treatment guidelines exist because there is no complete consensus among individual guidelines. Pain intervention procedures are widely practiced and highly associated with adverse events and complications. However, a comprehensive, systemic review of medical-dispute cases (MDCs) in Korea has not yet been reported...
October 2015: Korean Journal of Pain
https://www.readbyqxmd.com/read/26357577/scombrotoxinism-protracted-illness-following-misdiagnosis-in-the-emergency-department
#19
Ghan-Shyam Lohiya, Sapna Lohiya, Sunita Lohiya, Vijay Krishna
Background. Scombrotoxinism is an acute toxin-induced illness caused primarily by bacterial synthesis of histamine in decomposed fish. Case Report. Immediately after taking 2-3 bites of cooked salmon, a clerical worker developed oral burning, urticaria, and asthma. In the emergency department, she was diagnosed with "allergies"; scombrotoxinism was never considered. She then developed wide-ranging symptoms (e.g., chronic fatigue, asthma, anxiety, multiple chemical sensitivity, and paresthesiae) and saw many specialists (in pulmonology, otorhinolaryngology, allergy, toxicology, neurology, psychology, and immunology)...
2015: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/26345174/-analysis-of-judicial-sentences-issued-against-traumatologists-between-1995-and-2011-as-regards-medical-negligence
#20
Z Cardoso-Cita, B Perea-Pérez, M E Albarrán-Juan, M E Labajo-González, L López-Durán, F Marco-Martínez, A Santiago-Saéz
INTRODUCTION AND OBJECTIVES: Traumatology and Orthopaedic Surgery is one of the specialities with most complaints due to its scope and complexity. The aim of this study is to determine the characteristics of the complaints made against medical specialists in Traumatology, taking into account those variables that might have an influence both on the presenting of the complaint as well as on the resolving of the process. MATERIAL AND METHODS: An analysis was performed on 303 legal judgments (1995-2011) collected in the health legal judgements archive of the Madrid School of Medicine, which is linked to the Westlaw Aranzadi data base...
January 2016: Revista Española de Cirugía Ortopédica y Traumatología
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