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Paediatric diabetes

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https://www.readbyqxmd.com/read/29769806/paediatric-type-1-diabetes-2018-clinical-and-research-insights
#1
Stephen J Zborovski, Farid H Mahmud
The management of children and adolescents with type 1 diabetes continues to progress as clinical and technological innovations enter into practice. Variability in glucose readings can present a significant challenge for care providers, patients and families alike and recent research demonstrates that insulin selection and site-related lipohypertrophy can significantly influence blood glucose levels. New technology aims to improve both glycemic control and quality of life. New insulin analogues have been developed and insulin pumps and continuous glucose monitoring systems continue to evolve toward a fully closed-loop system...
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29693557/continuous-glucose-monitoring-in-resource-constrained-settings-for-hypoglycaemia-detection-looking-at-the-problem-from-the-other-side-of-the-coin
#2
Rubao Bila, Rosauro Varo, Lola Madrid, Antonio Sitoe, Quique Bassat
The appearance, over a decade ago, of continuous glucose monitoring (CGM) devices has triggered a patient-centred revolution in the control and management of diabetes mellitus and other metabolic conditions, improving the patient’s glycaemic control and quality of life. Such devices, the use of which remains typically restricted to high-income countries on account of their elevated costs, at present show very limited implantation in resource-constrained settings, where many other urgent health priorities beyond diabetes prevention and management still need to be resolved...
April 25, 2018: Biosensors
https://www.readbyqxmd.com/read/29689124/increasing-incidence-of-type-2-diabetes-in-new-zealand-children-15-years-of-age-in-a-regional-based-diabetes-service-auckland-new-zealand
#3
Natalia Sjardin, Peter Reed, Ben Albert, Fran Mouat, Phillipa J Carter, Paul Hofman, Wayne Cutfield, Alistair Gunn, Craig Jefferies
AIM: It is important to understand whether type 2 diabetes mellitus (T2DM) is increasing in childhood for health-care planning and clinical management. The aim of this study is to examine the incidence of T2DM in New Zealand children, aged <15 years from a paediatric diabetes centre, Auckland, New Zealand. METHODS: Retrospective analysis of prospectively collected data from a population-based referral cohort from 1995 to 2015. RESULTS: Hundred and four children presented with T2DM over the 21-year period...
April 24, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29682577/common-issues-seen-in-paediatric-diabetes-clinics-psychological-formulations-and-related-approaches-to-management
#4
REVIEW
Asma Deeb, Mariette Akle, Abdulla Al Ozairi, Fergus Cameron
Diabetes is a chronic disease and its management is associated with multiple challenges. This is particularly the case in children and adolescents. Factors that contribute to difficulties in managing diabetes in youth include psychological characteristics, family dynamics, and social behavior. The purpose of this article is to highlight some psychological issues in children and adolescents with diabetes. We aim to present selected case scenarios encountered by health professionals and to provide tips on strategies for managing psychological aspect of diabetes...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29622707/paediatric-non-ketotic-hyperglycaemic-hemichorea-hemiballismus
#5
Cezar Thomas Reyes Suratos, James Albert Edward Lim Benitez, Sheen Corvera Urquiza, Cheryl Anne Lubaton Sacro
Non-ketotic hyperglycaemic hemichorea-hemiballismus (NHHH) is commonly seen among elderly Asian women with type 2 diabetes mellitus. Here, we present a case of a 16-year-old Filipina with type 1 diabetes mellitus who is poorly compliant to her medications and subsequently developed right hemichorea-hemiballismus (HH). She was initially admitted with hyperglycaemia but was negative for ketonuria or metabolic acidosis. Neuroimaging showed bilateral lentiform nuclei and left caudate hyperdensities on CT and T1-weighted hyperintensity on MRI...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29611621/perception-attitude-and-satisfaction-of-paediatric-physicians-and-nurses-towards-clinical-practice-guidelines-at-a-university-teaching-hospital
#6
Yasser Sami Amer, Abdulrahman Al Nemri, Mohamed Elfaki Osman, Elshazaly Saeed, Asaad Mohamed Assiri, Sarar Mohamed
RATIONALE, AIMS, AND OBJECTIVES: To explore perception, attitude, and satisfaction of paediatric clinicians, trainees, and nurses at King Khalid University Hospital towards clinical practice guidelines (CPGs) including the locally adapted diabetic ketoacidosis CPG (DKA-CPG). METHODS: A cross-sectional survey was distributed to 260 doctors and nurses working in the paediatrics department. RESULTS: The response rate was 95.4%. The respondents had a positive perception and attitude towards general CPGs and specifically for the DKA-CPG; 98...
April 3, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29587254/evaluation-of-the-freestyle%C3%A2-libre-flash-glucose-monitoring-system-in-children-and-adolescents-with-type-1-diabetes
#7
Guy G Massa, Inge Gys, Anniek Op 't Eyndt, Esmiralda Bevilacqua, Anne Wijnands, Peter Declercq, Renate Zeevaert
BACKGROUND/AIMS: The FreeStyle® Libre Flash Glucose Monitoring System (FGM, Abbott) measures glucose concentrations in the interstitial fluid for up to 14 days. It has been approved for use in children aged > 4 years in January 2016. Experience in children is still limited. We evaluated the accuracy and usability of the FGM in children with type 1 diabetes mellitus (DM). METHODS: 67 children with type 1 DM (35 girls), aged 4-18 years, were included. Subjects wore a sensor on the back of their upper arm...
2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29577410/adult-care-providers-perspectives-on-the-transition-to-adult-care-for-emerging-adults-with-type-1-diabetes-a-cross-sectional-survey
#8
S Michaud, K Dasgupta, L Bell, J-F Yale, N Anjachak, S Wafa, M Nakhla
AIMS: To assess adult diabetes care providers' current transition practices, knowledge about transition care, and perceived barriers to implementation of best practices in transition care for emerging adults with Type 1 diabetes mellitus. METHODS: We administered a 38-item web-based survey to adult diabetes care providers identified through the Québec Endocrinologist Medical Association and Diabetes Québec. RESULTS: Fifty-three physicians responded (35%)...
March 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29569446/who-healthy-diet-to-prevent-chronic-diseases-and-caries
#9
L Paglia
For some years now, the WHO has recommended less than 10% of energy intake from free sugars. The same document also stresses the need to bring this limit below 5% as soon as possible. These guidelines have been promoted with the aim of reducing the prevalence of chronic non-communicable diseases such as diabetes, cardiovascular disease, obesity and metabolic syndrome. At the same time, the reduction of free sugars in the diet can be part of a strategy to reduce the prevalence of caries, which is known to be an infectious and transmissible multifactorial disease known to be "triggered" by wrong dietary habits...
March 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29534994/health-outcomes-for-youth-with-type-1-diabetes-at-18-months-and-30-months-post-transition-from-pediatric-to-adult-care
#10
K Farrell, R Fernandez, Y Salamonson, R Griffiths, D J Holmes-Walker
AIMS: To identify (a) determinants of glycated haemoglobin (HbA1c) at 18 and 30 months following transition in young people with Type 1 diabetes mellitus (T1DM) to a youth-specific diabetes service; and to (b) evaluate the impact of the service on acute admissions with diabetic ketoacidosis (DKA) over a 14-year period. METHODS: An audit of records of youth with T1DM referred from paediatric services to the multidisciplinary transition service at Westmead Hospital, from 2001 to 2012, and followed-up to 2014...
March 10, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29527790/immune-cell-and-cytokine-patterns-in-children-with-type-1-diabetes-mellitus-undergoing-a-remission-phase-a-longitudinal-study
#11
Ana Laura Fitas, Catarina Martins, Luís Miguel Borrego, Lurdes Lopes, Anne Jörns, Sigurd Lenzen, Catarina Limbert
OBJECTIVE: Type 1 diabetes (T1D) develops in distinct stages, before and after disease onset. Whether the natural course translates into different immunologic patterns is still uncertain. This study aimed at identifying peripheral immune patterns at key time-points, in T1D children undergoing remission phase. METHODS: Children with new-onset T1D and healthy age and gender-matched controls were recruited at a pediatric hospital. Peripheral blood samples were evaluated by flow cytometry at 3 longitudinal time-points: onset (T1), remission phase (T2) and established disease (T3)...
March 12, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29506377/-italian-cystic-fibrosis-registry-report-2011-2014
#12
Barbara Giordani, Annalisa Amato, Fabio Majo, Gianluca Ferrari, Serena Quattrucci, Laura Minicucci, Rita Padoan, Giovanna Floridia, Gianna Puppo Fornaro, Domenica Taruscio, Marco Salvatore
INTRODUCTION: The Italian Cystic Fibrosis Registry (ICFR) is based on a new agreement about the data flow towards the Registry signed on October, 4th 2016 by the Centre for Rare Diseases of the Italian National Institute of Health (NIH), the clinicians of the Italian National Referral and Support Centres for Cystic Fibrosis, the Paediatric Hospital "Bambino Gesù" (Rome), the Italian Cystic Fibrosis Society, and the Italian League for Cystic Fibrosis. OBJECTIVES: The aim of the present Report is to improve the knowledge on cystic fibrosis (CF) through the epidemiological description of Italian patients...
January 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29484782/diabetic-ketoacidosis-incidence-in-children-at-first-presentation-of-type-1-diabetes-at-an-australian-regional-hospital-the-effect-of-health-professional-education
#13
Radhika Patwardhan, Susan Gorton, Venkat N Vangaveti, Jason Yates
BACKGROUND: Diabetic ketoacidosis (DKA) is an acute life threatening, resource intensive preventable complication of type 1 diabetes which has major biopsychosocial effects on patients and families. Incidence of pediatric DKA has been studied nationally and internationally in metropolitan centers. This study analyzed the DKA incidence at first presentation of type 1 diabetes at Townsville Hospital, before and after an educational intervention. This is the first study of its kind in a regional center in Queensland, Australia...
February 27, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29475800/macrovascular-disease-and-risk-factors-in-youth-with-type-1-diabetes-time-to-be-more-attentive-to-treatment
#14
REVIEW
Petter Bjornstad, Kim C Donaghue, David M Maahs
Cardiovascular disease remains the leading cause of mortality in patients with type 1 diabetes. Although cardiovascular disease complications are rare until adulthood, pathology and early markers can manifest in adolescence. Whereas advances have been made in the management of microvascular complications of type 1 diabetes, similar progress in reducing macrovascular complications has not been made. The reasons for the absence of progress remain incompletely understood, but most likely relate to the long time needed for cardiovascular disease to manifest clinically and hence for risk factor management to show a clinical benefit, thus allowing inertia to prevail for diagnosis and particularly for targeting risk factors...
February 20, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29464737/copeptin-role-in-polyuria-polydipsia-syndrome-differential-diagnosis-and-reference-range-in-paediatric-age
#15
Gerdi Tuli, Daniele Tessaris, Silvia Einaudi, Patrizia Matarazzo, Luisa De Sanctis
OBJECTIVE: Plasma arginine-vasopressin (AVP) analysis can help in the differential diagnosis of the polyuria-polydipsia syndrome (PPS), even if such investigation is hampered by technical difficulties, conversely to its surrogate copeptin. This study aims to enlarge the existing data on normal copeptin levels in childhood, to evaluate the correlation between copeptin, serum sodium and plasma and urine osmolality, and to assess the utility of the copeptin analysis in the diagnostic work-up of PPS in the paediatric age...
February 21, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29460641/novel-blood-glucose-lowering-therapies-for-managing-type-1-diabetes-in-paediatric-patients
#16
REVIEW
Anda Mihaela Naciu, Paolo Pozzilli
Therapy for type 1 diabetes (T1D) is mainly restricted to insulin treatment. The management of paediatric patients with T1D should tackle not only glucose control, but also insulin resistance, beta-cell preservation, quality of life and cardiovascular disease risk factors, which are increasingly recognized to occur in adolescents with T1D. Areas covered: This review examines the recently published literature from PubMed on non-insulin agents for the management of T1D in paediatric patients. Expert opinion: Few paediatric patients with T1D are achieving their metabolic targets...
March 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29460341/continuing-rise-of-type-2-diabetes-incidence-in-children-and-young-people-in-the-uk
#17
T P Candler, O Mahmoud, R M Lynn, A A Majbar, T G Barrett, J P H Shield
AIMS: To estimate the incidence of Type 2 diabetes in children aged <17 years, compare this with similar data 10 years ago, and characterize clinical features at diagnosis in the UK and Republic of Ireland. METHODS: Using the British Paediatric Surveillance Unit reporting framework, cases of Type 2 diabetes diagnosed in children aged <17 years between 1 April 2015 and 30 April 2016 were reported each month. RESULTS: A total of 106 cases were reported, giving a UK incidence of 0...
February 20, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29453208/parent-reported-prevalence-and-persistence-of-19-common-child-health-conditions
#18
Tracy Liu, Raghu Lingam, Kate Lycett, Fiona K Mensah, Joshua Muller, Harriet Hiscock, Md Hamidul Huque, Melissa Wake
OBJECTIVE: To estimate prevalence and persistence of 19 common paediatric conditions from infancy to 14-15 years. DESIGN: Population-based prospective cohort study. SETTING: Australia. PARTICIPANTS: Parallel cohorts assessed biennially from 2004 to 2014 from ages 0-1 and 4-5 years to 10-11 and 14-15 years, respectively, in the Longitudinal Study of Australian Children. MAIN OUTCOME MEASURES: 19 health conditions: 17 parent-reported, 2 (overweight/obesity, obesity) directly assessed...
February 16, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29428572/metabolic-control-and-complications-in-italian-people-with-diabetes-treated-with-continuous-subcutaneous-insulin-infusion
#19
Giuseppe Lepore, Riccardo Bonfanti, Lutgarda Bozzetto, Vincenzo Di Blasi, Angela Girelli, Giorgio Grassi, Dario Iafusco, Luigi Laviola, Ivana Rabbone, Riccardo Schiaffini, Daniela Bruttomesso
BACKGROUND AND AIM: The objective of this cross-sectional study was to evaluate the degree of glycaemic control and the frequency of diabetic complications in Italian people with diabetes who were treated with continuous subcutaneous insulin infusion (CSII). METHODS AND RESULTS: Questionnaires investigating the organisation of diabetes care centres, individuals' clinical and metabolic features and pump technology and its management were sent to adult and paediatric diabetes centres that use CSII for treatment in Italy...
April 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29415687/a-physical-activity-intervention-for-children-with-type-1-diabetes-steps-to-active-kids-with-diabetes-stak-d-a-feasibility-study
#20
Helen Quirk, Cris Glazebrook, Holly Blake
BACKGROUND: This study describes the development and feasibility evaluation of a physical activity intervention for children with type 1 diabetes called 'Steps to Active Kids with Diabetes' (STAK-D). It aims to explore the feasibility and acceptability of the intervention and study design. METHODS: Thirteen children aged 9-11 years and their parents were recruited from one paediatric diabetes clinic. A process evaluation was conducted alongside a two-arm randomised feasibility trial, including assessment of rate of recruitment, adherence, retention, data completion and burden, implementation fidelity and adverse events...
February 7, 2018: BMC Pediatrics
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