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Paediatric diabetes

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https://www.readbyqxmd.com/read/29342279/incidence-and-predictors-of-post-transplant-lymphoproliferative-disease-after-kidney-transplantation-during-adulthood-and-childhood-a-registry-study
#1
Anna Francis, David W Johnson, Armando Teixeira-Pinto, Jonathan C Craig, Germaine Wong
Background: Differences in the epidemiology of post-transplant lymphoproliferative disease (PTLD) between adult and paediatric kidney transplant recipients remain unclear. Methods: Using the Australian and New Zealand Dialysis and Transplant Registry (1963-2015), the cumulative incidences of PTLD in children (age <20 years) and adults were calculated using a competing risk of death model and compared with age-matched population-based data using standardized incidence ratios (SIRs)...
January 12, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29298818/fifteen-minute-consultation-insulin-pumps-for-type-1-diabetes-in-children-and-young-people
#2
Philippa Prentice, Daniela Elleri
There is increasing worldwide use of continuous subcutaneous insulin infusions in paediatric type 1 diabetes (T1D), reflecting recent research outcomes and guidance, as well as families' wishes. Children/young people may present acutely with medical or surgical problems, in addition to issues related to T1D. This review provides general paediatricians with an introduction to pump therapy, highlighting common problems, management issues and when to seek specialist advice.
January 3, 2018: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29295580/diabetic-ketoacidosis-severity-at-diagnosis-and-glycaemic-control-in-the-first-year-of-childhood-onset-type-1-diabetes-a-longitudinal-cohort-study
#3
Amal R Khanolkar, Rakesh Amin, David Taylor-Robinson, Russell M Viner, Justin Warner, Evelien F Gevers, Terence Stephenson
It is unclear whether diabetic ketoacidosis (DKA) severity at diagnosis affects the natural history of type 1 diabetes (T1D). We analysed associations between DKA severity at diagnosis and glycaemic control during the first year post-diagnosis. We followed 341 children with T1D, <19 years (64% non-white) attending paediatric diabetes clinics in East London. Data were extracted from routine medical registers. Subjects were categorized with normal, mild, moderate, or severe DKA. Linear mixed-effects modelling was used to assess differences in longitudinal HbA1c trajectories (glycaemic control) during 12 months post-diagnosis (1288 HbA1c data-points) based on DKA, adjusting for sex, age, ethnicity, SES (Socioeconomic Status) and treatment type...
December 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29259053/primary-outcomes-reporting-in-trials-of-paediatric-type-1-diabetes-mellitus-a-systematic-review
#4
Samaneh Khanpour Ardestani, Mohammad Karkhaneh, Hai Chuan Yu, Muhammad Zafar Iqbal Hydrie, Sunita Vohra
OBJECTIVE: Our objective was to systematically review randomised clinical trials (RCTs) of paediatric type 1 diabetes mellitus (T1DM) to assess reporting of (1) primary outcome, (2) outcome measurement properties and (3) presence or absence of adverse events. METHODS: Electronic searches in MEDLINE, EMBASE, CINAHL, Cochrane SR and the Cochrane Central Register of Controlled Trials (CENTRAL) databases were undertaken. The search period was between 2001 and 2017. English-language RCTs on children younger than 21 years with T1DM were selected...
December 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/29246154/dexamethasone-implants-in-paediatric-patients-with-noninfectious-intermediate-or-posterior-uveitis-first-prospective-exploratory-case-series
#5
Sibylle Winterhalter, Uwe Diedrich Behrens, Daniel Salchow, Antonia M Joussen, Uwe Pleyer
BACKGROUND: To evaluate the efficacy and safety of dexamethasone (DEX) implants in paediatric patients with noninfectious intermediate or posterior uveitis. METHODS: Prospective single center exploratory case series. Children and adolescents, 6 to 17 years old, with a vitreous haze score of ≥1.5+ or cystoid macular edema (CME) of >300 μm were enrolled. Vitreous haze score at month 2 was chosen as primary endpoint. Best corrected visual acuity (BCVA), central retinal thickness (CRT) and concomitant medication at month 6 were defined as secondary endpoints...
December 16, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29211844/the-association-between-asthma-and-type-1-diabetes-a-paediatric-case-cohort-study-in-finland-years-1981-2009
#6
Johanna Metsälä, Annamari Lundqvist, Lauri J Virta, Minna Kaila, Mika Gissler, Suvi M Virtanen, Jaakko Nevalainen
Background: The association between asthma and type 1 diabetes, two chronic, immune-mediated diseases, has been of longstanding interest, but the evidence is still conflicting. We examined this association in a large, nationwide case-cohort study among Finnish children, using a novel statistical approach. Methods: Among the initial cohort of all children born between 1 January 1981 and 31 December 2008, those who were diagnosed with asthma (n = 81 473) or type 1 diabetes (n = 9541) up to age 16 years by the end of 2009 were identified from the Central Drug Register maintained by the Social Insurance Institution of Finland...
December 2, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29171079/a-survey-of-staffing-levels-in-paediatric-diabetes-services-throughout-the-uk
#7
D Charalampopoulos, R Amin, J T Warner, R M Viner, F Campbell, J A Edge, T Stephenson
AIMS: To assess staffing levels of healthcare professionals involved in the care of children and young people with diabetes in the UK. METHODS: A web-based questionnaire was distributed to lead consultant paediatricians from all paediatric diabetes services in the UK between October and December 2014. Data on staffing levels and other aspects of diabetes services were collected and differences between the four nations of the UK and across the 10 English diabetes networks were explored...
November 24, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29150413/-the-situation-as-regards-diabetes-mellitus-type-1-in-andalusia-care-data-use-of-advanced-therapies-and-human-resources
#8
Juan Pedro López Siguero, Olga Pérez González, Ana Lucía Gómez Gila, Isabel Leiva Gea
INTRODUCTION: The representation of Spain in European epidemiological studies on diabetes is limited, with only one centre in the Hvidoere study and another in the SWEET study. No Spanish studies have been published that combine epidemiological data and care resources. The aim of this study was to determine the epidemiological data, care resources, and use of new technologies in all Andalusian hospitals that care for children with Diabetes Mellitus type 1 (DM1) under 14 years. MATERIAL AND METHODS: An electronic questionnaire of 18 questions was sent to all paediatric endocrinologists who treated children with diabetes in Andalusian hospitals...
November 14, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29146656/prevalence-of-diabetic-retinopathy-in-children-and-young-people-living-with-diabetes-protocol-for-a-systematic-review
#9
Maria Carolina Ibanez-Bruron, Ameenat L Solebo, Phillippa M Cumberland, Jugnoo S Rahi
INTRODUCTION: The frequency of diabetes mellitus in childhood is increasing. Thus, more children and young people are at risk of developing diabetic retinopathy and diabetes related visual impairment. However, there is no consensus on optimal screening strategies for the paediatric population reflecting the lack of clarity about the current burden of disease in this group. We aim to estimate the prevalence of diabetic retinopathy in children and young people living with types 1 or 2 diabetes, and to investigate potential sources of heterogeneity in this figure so as to inform screening strategies for this population...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29144024/epidemiology-of-type-1-diabetes-in-polish-children-a-multicentre-cohort-study
#10
Mieczysław Szalecki, Marta Wysocka-Mincewicz, Anna Ramotowska, Artur Mazur, Lucyna Lisowicz, Iwona Ben-Skowronek, Joanna Sieniawska, Bożena Klonowska, Dorota Charemska, Jolanta Nawrotek, Irena Jałowiec, Artur Bossowski, Milena Jamiołkowska, Beata Pyrżak, Grażyna Miszkurka, Agnieszka Szypowska
BACKGROUND: The incidence of childhood Type-1 diabetes (T1D) varies greatly between populations and the estimates and/or predictions of the rates would aid in adequate planning of health care resources. The study's aim was to assess the incidence of T1D in the paediatric population of eastern and central Poland. METHODS: In this cohort study covering the period from January 2010 to December 2014 data were collected for children and adolescents below 18 years of age with newly diagnosed T1D, living in eastern and central Poland...
November 16, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29073289/pm10-concentration-and-microbiological-assessment-of-air-in-relation-to-the-number-of-acute-cases-of-type-1-diabetes-mellitus-in-the-lubelskie-voivodeship-preliminary-report
#11
Małgorzata Michalska, Maria Bartoszewicz, Piotr Wąż, Sylwia Kozaczuk, Iwona Beń-Skowronek, Katarzyna Zorena
INTRODUCTION: The aim of our study was to evaluate the relation between the concentration of particulate matter of less than 10 μm in diameter (PM10) in air and the effect of psychrophilic bacteria, mesophilic bacteria and mould fungi on the number of new cases of type 1 diabetes mellitus in children and adolescents in the Lubelskie Voivodeship in the years 2015-2016. PATIENTS AND METHODS: Epidemiological data on the number of new cases of T1DM was obtained from the Department of Paediatric Endocrinology and Diabetology of the Medical University in Lublin...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29025837/effects-of-lactobacillus-rhamnosus-gg-and-bifidobacterium-lactis-bb12-on-beta-cell-function-in-children-with-newly-diagnosed-type-1-diabetes-protocol-of-a-randomised-controlled-trial
#12
Lidia Groele, Hania Szajewska, Agnieszka Szypowska
INTRODUCTION: Recent evidence has demonstrated that, among other factors, dysbiosis (imbalances in the composition and function of the gut microbiota) may be relevant in the development of type 1 diabetes (T1D). Thus, gut microbiota may be a target for improving outcomes in subjects with T1D. The aim of the study is to examine the effects of Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 on beta-cell function in children with newly diagnosed T1D. METHODS AND ANALYSIS: A total of 96 children aged 8 to 17 years with newly diagnosed T1D, confirmed by clinical history and the presence of at least one positive autoantibody, will be enrolled in a double-blind, randomised, placebo-controlled trial in which they will receive L...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28989569/clinical-profile-of-diabetes-at-diagnosis-among-children-and-adolescents-at-an-endocrine-clinic-in-ghana
#13
Emmanuel Ameyaw, Serwah B Asafo-Agyei, Sumithira Thavapalan, Angela C Middlehurst, Graham D Ogle
AIM: To determine the clinical features of diabetes in children and adolescents in Ghana. METHODS: Retrospective review of clinical features of all children and adolescents with new-onset diabetes seen at the paediatric endocrinology clinic of Komfo Anokye Teaching Hospital in Kumasi, from February 2012 to Auguest 2016. RESULTS: One hundred and six subjects presented with diabetes. Ninety (84.9%) were diagnosed by clinical features and family history as type 1, and 16 (15...
September 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28978574/in-the-setting-of-paediatric-osteomyelitis-do-not-be-afraid-to-cast-an-eye
#14
Rebecca Anne Russell, Edina Moylett
The case commences with an innocuous right ankle injury (lateral malleolus), for which the patient, a 9-year-old boy, was placed in a temporary cast at his local hospital. Three days following this incident, the patient was diagnosed with new-onset type 1 diabetes mellitus. He was admitted to his local hospital with severe diabetic ketoacidosis appropriately treated and subsequently discharged c.1 week later clinically well. Approximately 1 week later, again he presented for a third time with a significant serosanguinous discharge from the site of the initial injury permeating through the temporary cast in place for c...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28975759/acute-kidney-injury-in-paediatric-diabetic-ketoacidosis-a-missed-opportunity
#15
Tristan W Harding, Catie A Fleming
No abstract text is available yet for this article.
October 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28957985/evidence-supporting-serology-based-pathway-for-diagnosing-coeliac-disease-in-asymptomatic-children-from-high-risk-groups
#16
Siba Prosad Paul, Bhupinder Kaur Sandhu, Christine Helen Spray, Dharamveer Basude, Pramila Ramani
OBJECTIVE: The European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guidelines for diagnosing coeliac disease (CD) in children were modified in 2012. They recommend that in symptomatic children with anti-tissue transglutaminase antibody (anti-tTG) titre of greater than 10-times upper limit of normal (>10xULN) and who have positive anti-endomysial antibody and HLA-DQ2/DQ8 haplotype, the diagnosis of CD can be based on serology. Aim of this study is to establish whether serology-based pathway of the ESPGHAN guidelines could also be reliably applied to asymptomatic children from high-risk groups...
September 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28922262/sugar-in-infants-children-and-adolescents-a-position-paper-of-the-european-society-for-paediatric-gastroenterology-hepatology-and-nutrition-committee-on-nutrition
#17
Nataša Fidler Mis, Christian Braegger, Jiri Bronsky, Cristina Campoy, Magnus Domellöf, Nicholas D Embleton, Iva Hojsak, Jessie Hulst, Flavia Indrio, Alexandre Lapillonne, Walter Mihatsch, Christian Molgaard, Rakesh Vora, Mary Fewtrell
The consumption of sugars, particularly sugar-sweetened beverages (SSBs; beverages or drinks that contain added caloric sweeteners (ie, sucrose, high-fructose corn syrup, fruit juice concentrates), in European children and adolescents exceeds current recommendations. This is of concern because there is no nutritional requirement for free sugars, and infants have an innate preference for sweet taste, which may be modified and reinforced by pre- and postnatal exposures. Sugar-containing beverages/free sugars increase the risk for overweight/obesity and dental caries, can result in poor nutrient supply and reduced dietary diversity, and may be associated with increased risk of type 2 diabetes mellitus, cardiovascular risk, and other health effects...
December 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28915908/advances-in-paediatrics-in-2016-current-practices-and-challenges-in-allergy-autoimmune-diseases-cardiology-endocrinology-gastroenterology-infectious-diseases-neonatology-nephrology-neurology-nutrition-pulmonology
#18
REVIEW
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Sergio Bernasconi
This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28901704/audit-of-the-dietetic-care-of-patients-with-type-1-diabetes-at-a-large-australian-paediatric-tertiary-hospital-and-comparison-with-the-international-society-for-paediatric-and-adolescent-diabetes-nutrition-guidelines
#19
Rachel Battersby, Annabel Sweeney, Sarah Toome, Janice Fairchild, Jacqueline Miller
AIM: Optimal glycaemic control is important in children and adolescents with type 1 diabetes (T1D) to reduce the risk of developing microvascular complications. Modest reductions in HbA1c translate to significant risk reductions of these complications. Research indicates that targeted dietetic care using evidence-based guidelines improves HbA1c levels. The aim of this study was to audit the dietetic care provided to patients with T1D at the Women's and Children's Hospital (WCH) and compare the service provided to the International Society for Paediatric and Adolescent Diabetes (ISPAD) nutrition guidelines...
September 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28819992/insulin-delivery-and-nocturnal-glucose-control-in-children-and-adolescents-with-type-1-diabetes
#20
Martin Tauschmann, Roman Hovorka
Nocturnal glucose control remains challenging in children and adolescents with type 1 diabetes due to highly variable overnight insulin requirements. The issue may be addressed by glucose responsive insulin delivery based on real-time continuous glucose measurements. Areas covered: This review outlines recent developments of glucose responsive insulin delivery systems from a paediatric perspective. We cover threshold-based suspend application, predictive low glucose suspend, and more advanced single hormone and dual-hormone closed-loop systems...
August 18, 2017: Expert Opinion on Drug Delivery
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