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L arginin

Hossein Tavallali, Gohar Deilamy-Rad, Narges Mosallanejad
In the current study, we reported a novel label-free and facile colorimetric approach for the sequential detection of copper ion (Cu2+ ), L-arginine (Arg), and L-cysteine (Cys) in the H2 O (10.0 mmol L-1 HEPES buffer solution, pH 7.0) using Reactive Blue 4 (RB4). First, the presence of Cu2+ led to a naked-eye color and spectral changes according to the binding site-signaling subunit approach. Then, the RB4-Cu2+ complex was successfully applied for Cys and Arg through different recognition pathways. The optical signals for Arg were observed due to its association involving the amino group, as well as the participation of the carboxylate group in a bidentate form to the complex, while selective behavior for Cys was explained by a metal displacement mechanism...
August 13, 2018: Applied Biochemistry and Biotechnology
Ruslan Garifullin, Dmitriy S Blokhin, Rezeda A Akhmadishina, Natalia V Petrova, Alexandra M Kusova, Vladimir V Klochkov, Timur I Abdullin
Chemical modification of therapeutic peptides is an important approach to improving their physicochemical and pharmacokinetic properties. The triphenylphosphonium (TPP) cation has proved to be a powerful modifier; however, its effects on peptide structure and activity remain uncharacterized. In this study, cytoprotective tetrapeptides based on the YRFK opioid motif with L- or D-Arg residues were linked to (triphenylphosphonio)carboxylic acids with ethylene and pentylene spacers (TPP-3 and TPP-6 groups, respectively)...
August 13, 2018: European Biophysics Journal: EBJ
Robert Lyle McPherson, Shao-En Ong, Anthony K L Leung
ADP-ribosylation is a posttranslational modification that involves the conjugation of monomers and polymers of the small molecule ADP-ribose onto amino acid side chains. A family of ADP-ribosyltransferases catalyzes the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD+ ) onto a variety of amino acid side chains including aspartate, glutamate, lysine, arginine, cysteine, and serine. The monomeric form of the modification mono(ADP-ribosyl)ation (MARylation) is reversed by a number of enzymes including a family of MacroD-type macrodomain-containing mono(ADP-ribose) (MAR) hydrolases...
2018: Methods in Molecular Biology
N C Adams, T P Farrell, A O'Shea, A O'Hare, J Thornton, S Power, P Brennan, S Looby
Central or neurogenic diabetes insipidus (CDI) is due to deficient synthesis or secretion of antidiuretic hormone (ADH), also known as arginine vasopressin peptide (AVP). It is clinically characterised by polydipsia and polyuria (urine output > 30 mL/kg/day) of dilute urine (< 250 mOsm/L). It is the result of a defect in one of more sites involving the hypothalamic osmoreceptors, supraoptic or paraventricular nuclei of the hypothalamus, median eminence of the hypothalamus, infundibulum or the posterior pituitary gland...
August 10, 2018: Neuroradiology
Yan-Lun Ju, Guo-Qian Xu, Xiao-Feng Yue, Xian-Fang Zhao, Ting-Yao Tu, Jun-Xiang Zhang, Yu-Lin Fang
Amino acid contents and their derived volatile compositions in Cabernet Sauvignon grapes and wines after regulated deficit irrigation (RDI) were investigated during the 2015 and 2016 growing seasons in Yinchuan (NingXia, China). High-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) were used for amino acid and volatile compound analyses. Three RDI strategies were tested: 60% (RDI-1), 70% (RDI-2), and 80% (RDI-3) of grapevine estimated evapotranspiration (ETc), and 100% ETc was used as the control group (CK)...
August 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Meiyu Huang, Honglian Ai, Xiaoxiang Xu, Ke Chen, Hong Niu, Huihui Zhu, Jie Sun, Dongyun Du, Liang Chen
Tall fescue (Festuca arundinacea Schreb) was widely studied for phytoremediation of organic or heavy metal contaminated soils. However, there is still little information concerning toxicity of chromium (Cr) to tall fescue and roles of nitric oxide (NO) in plants against Cr(VI) stress. In this study, different Cr(VI) treatments (0, 1, 5 and 10 mg/L Cr(VI)) and NO treatments were applied with different combinations in hydroponics culture and their interactions to tall fescue were studied. Specifically, 100 µM sodium nitroprusside (SNP) and 100 µM NG -nitro-L-arginine-methyl ester (L-NAME) treatments were used to apply exogenous NO or inhibit synthesis of NO respectively...
August 7, 2018: Ecotoxicology and Environmental Safety
Sana Mallek-Ayadi, Neila Bahloul, Nabil Kechaou
BACKGROUND: This study investigated amino acid composition, phenolic coumpounds and volatiles profile of Maazoun melon seeds. The functional properties of melon seed flour such as bulk density, swelling capacity, emulsifying capacity and foaming capacity were also determined. RESULTS: The findings proved that the functional properties of melon seeds make them useful for incorporation into different food formulations to improve their functionality. The determination of amino acid composition of melon seeds showed that glutamic acid (205...
August 9, 2018: Journal of the Science of Food and Agriculture
Donghai Liang, Jennifer L Moutinho, Rachel Golan, Tianwei Yu, Chandresh N Ladva, Megan Niedzwiecki, Douglas I Walker, Stefanie Ebelt Sarnat, Howard H Chang, Roby Greenwald, Dean P Jones, Armistead G Russell, Jeremy A Sarnat
BACKGROUND: High-resolution metabolomics (HRM) is emerging as a sensitive tool for measuring environmental exposures and biological responses. The aim of this analysis is to assess the ability of high-resolution metabolomics (HRM) to reflect internal exposures to complex traffic-related air pollution mixtures. METHODS: We used untargeted HRM profiling to characterize plasma and saliva collected from participants in the Dorm Room Inhalation to Vehicle Emission (DRIVE) study to identify metabolic pathways associated with traffic emission exposures...
August 6, 2018: Environment International
Nirmal S Sharma, Charitharth Vivek Lal, Jin-Dong Li, Xiang-Yang Lou, Liliana Viera, Tarek Abdallah, Robert King, Jaskaran Sethi, Prashanth Kanagarajah, Ricardo Restrepo-Jaramillo, Amanda Sales-Conniff, Shi Wei, Patricia L Jackson, J Edwin Blalock, Amit Gaggar, Xin Xu
ARDS is characterized by unrelenting PMN inflammation and vascular permeability. The matrikine proline-glycine-proline (PGP) and acetylated PGP (Ac-PGP) have been shown to induce PMN inflammation and endothelial permeability in vitro and in vivo. In this study, we investigated the presence and role of airway PGP peptides in acute lung injury (ALI)/ARDS. P. aeruginosa-derived LPS was instilled intratracheally (i.t) in mice to induce ALI and increased Ac-PGP with neutrophil inflammation was noted. The PGP inhibitory peptide, RTR (arginine-threonine-arginine), was administered (i...
August 9, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
X Y Zhang, M K Zhu, C Yuan, X T Zou
The goal of this study was to investigate the influence of l-arginine (l-Arg) supplementation on diet-induced changes in hypothalamus and liver proteome of laying hens. Layers were fed either an isonitrogenous control diet or a l-Arg diet. The test included a 2-week acclimation period and a 12-week experimental period. Eight layers per group were sacrificed at terminal of the experiment underwent 12 fasting. Blood and tissue samples of hypothalamus and liver were collected for further analysis. The levels of serum nitric oxide and hypothalamus neuropeptide Y of layers in l-Arg group were increased in comparison with those in control group...
August 8, 2018: Journal of Animal Physiology and Animal Nutrition
Jian Ying Yang, Yong Fa Zhang, Yuan Xiao Li, Xiang Ping Meng, Jian Feng Bao
To explore the protective mechanism of l-arginine against T-2 toxin-induced oxidative damage in mouse Leydig cells, Leydig cells were isolated and cultured with control, T-2 toxin (10 nM), l-arginine (0.25, 0.5, and 1.0 mM), and T-2 toxin (10 nM T-2 toxin) with l-arginine (0.25, 0.5, or 1.0 mM) for 24 hours. Cells and supernatants were harvested to examine cell viability, activities, and messenger RNA (mRNA) expression of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), malondialdehyde (MDA) content, and DNA damage...
August 8, 2018: Journal of Biochemical and Molecular Toxicology
Tamaki Suganuma, Selene K Swanson, Madelaine Gogol, Timothy J Garrett, Juliana Conkright-Fincham, Laurence Florens, Michael P Washburn, Jerry L Workman
Metabolic disorder has been suggested to underlie Alzheimer's disease (AD). However, the decisive molecular linkages remain unclear. We discovered that human Molybdopterin Synthase Associating Complex, MPTAC, promotes sulfur amino acid catabolism to prevent oxidative damage from excess sulfur amino acids, which, in turn, advances fatty acid oxidation and acetyl coenzyme A (acetyl-CoA) synthesis. The association of MPTAC with Protein arginine (R) Methyltransferase 5 (PRMT5) complex and small nuclear ribonucleoprotein (SNRP) splicing factors enables SNRPs to sense metabolic states through their methylation...
August 7, 2018: Cell Reports
Chao Wang, Cuicui Kang, Yihan Xian, Mingyu Zhang, Xiaolin Chen, Mingcai Pei, Weiyun Zhu, Suqin Hang
Nutrients regulate the secretion of gut satiety hormones, which is related to the modulation of food intake and blood glucose levels. Calcium-sensing receptor (CaSR) is involved in regulating gut hormone secretion in response to l-amino acids and multivalent cations. Rodents are often used to investigate the effect of nutrients on these hormonal release. However, results obtained using rodent models are difficult to be applied in humans, we used pigs as a model in this study because their physiology is similar to that of humans...
August 8, 2018: Journal of Food Science
Xin Li, Ji-Peng Wei, Golam J Ahammed, Lan Zhang, Yang Li, Peng Yan, Li-Ping Zhang, Wen-Yan Han
Temperature is a major environmental signal that governs plant growth and development. A moderately high ambient temperature alters plant metabolism without significant induction of heat-stress responses. Despite ancillary reports on the negative effect of warmer climate on tea quality, information on specific effect of sub high temperature (SHT) on theanine accumulation is scanty. L-Theanine is the most abundant free amino acid in tea ( Camellia sinensis L.) leaves that contributes to the unique umami flavor of green tea infusion...
2018: Frontiers in Plant Science
Bernardo J Krause, Paola Casanello, Ana C Dias, Paulina Arias, Victoria Velarde, German A Arenas, Marcelo D Preite, Rodrigo Iturriaga
Chronic intermittent hypoxia (CIH), the main attribute of obstructive sleep apnea (OSA), produces oxidative stress, endothelial dysfunction, and hypertension. Nitric oxide (NO) plays a critical role in controlling the vasomotor tone. The NO level depends on the L-arginine level, which can be reduced by arginase enzymatic activity, and its reaction with the superoxide radical to produce peroxynitrite. Accordingly, we hypothesized whether a combination of an arginase inhibitor and an antioxidant may restore the endothelial function and reduced arterial blood pressure (BP) in CIH-induced hypertensive rats...
2018: Frontiers in Physiology
Hsiao P J Voon, Maheshi Udugama, Wendi Lin, Linda Hii, Ruby H P Law, David L Steer, Partha P Das, Jeffrey R Mann, Lee H Wong
An array of oncogenic histone point mutations have been identified across a number of different cancer studies. It has been suggested that some of these mutant histones can exert their effects by inhibiting epigenetic writers. Here, we report that the H3.3 G34R (glycine to arginine) substitution mutation, found in paediatric gliomas, causes widespread changes in H3K9me3 and H3K36me3 by interfering with the KDM4 family of K9/K36 demethylases. Expression of a targeted single-copy of H3.3 G34R at endogenous levels induced chromatin alterations that were comparable to a KDM4 A/B/C triple-knockout...
August 7, 2018: Nature Communications
J J Wang, A D Colella, D Beroukas, T K Chataway, T P Gordon
Anti-double-stranded (ds)DNA autoantibodies are prototypic serological markers of systemic lupus erythematosus (SLE) but little is known about their immunoglobulin variable (IgV) region composition at the level of the secreted (serum) proteome. Here, we use a novel proteomic workflow based on de novo database mass spectrometric sequencing of anti-dsDNA precipitins to analyse IgV subfamily expression and mutational signatures of high-affinity, precipitating anti-dsDNA responses. Serum anti-dsDNA proteomes were oligoclonal with shared (public) expression of IgG heavy chain variable region (IGHV) and kappa chain variable region (IGKV) subfamilies...
August 7, 2018: Clinical and Experimental Immunology
Arshia, Almas Jabeen, Aisha Faheem, Khalid Mohammed Khan, Shazia Shah, Shahnaz Perveen
BACKGROUND: Inflammation is a biological rejoinder of vascular tissues against destructive agents e.g. irritants, damaged cell or pathogens. During inflammation respiratory burst occur by activated phagocytes helps to destroy invading pathogens. Phagocytic cells such as neutrophils and macrophages are one of the major sources of reactive oxygen species (ROS) and nitric oxide (NO). Normally the redox environment is maintained by various antioxidant defense systems, however, these reactive oxygen species may be destructive and can lead to various pathological conditions...
August 5, 2018: Medicinal Chemistry
L Zeng, N Chen, Q Ning, Y Yao, H Chen, R Dang, H Zhang, C Lei
With the proposed global climate change, heat tolerance is becoming increasingly important to the sustainability of livestock production systems. Results from previous studies showed that variants in the prolactin releasing hormone (PRLH) (AC_000160.1:g.11764610G>A) and superoxide dismutase 1 (SOD1) (AC_000158.1:g.3116044T>A) genes play an important role in heat tolerance in African indicine cattle. However, it is unknown whether or not the mutations are associated with heat tolerance in Chinese cattle...
August 5, 2018: Animal Genetics
H L A Silva, C F Balthazar, R Silva, A H Vieira, R G B Costa, E A Esmerino, M Q Freitas, A G Cruz
Prato cheese, a typical ripened Brazilian cheese, contains high levels of sodium, and the excess intake of this micronutrient is associated with hypertension and cardiovascular diseases. A technological alternative to reduce the sodium content in foods is to replace NaCl with KCl and the addition of flavor enhancers. The present study aimed to combine quantitative descriptive analysis (QDA) and temporal dominance of sensations (TDS) to assess the sensory profile of reduced-sodium probiotic prato cheese with the addition of flavor enhancers...
August 1, 2018: Journal of Dairy Science
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