Read by QxMD icon Read

Vitamin AND D AND Testosterone

Juan Mielgo-Ayuso, Julio Calleja-González, Aritz Urdampilleta, Patxi León-Guereño, Alfredo Córdova, Alberto Caballero-García, Diego Fernandez-Lázaro
INTRODUCTION: Deficient levels of 25-hydroxyvitamin D (25(OH)D) (<30 ng/mL) may compromise health and athletic performance. Supplementation with oral vitamin D can favor the state of iron metabolism, and testosterone and cortisol as an indicator of muscle recovery of the athlete with a deficiency. The main aim of this study was to evaluate the influence of eight weeks of supplementation with 3000 IU/day of vitamin D on the hematological and iron metabolism profile, as well as on the analytical values of testosterone and cortisol on elite male traditional rowers...
December 12, 2018: Nutrients
J X Wang, Y Yu, M T Han, G G Wang, S M Yang, W Wang, H Li
Objective: To analyze the effect of insufficient intake of vitamin D (VD) on sperm quality and male fertility and to discuss the mechanism of the effect. Methods: VD deficiency mice were fed with VD-deficient diet and light-sheltered. The sperm motility, morphology, ultrastructure, testicular pathology, sex hormones and fertility of normal and VD-deficient mice were analyzed to investigate the effects of VD deficiency on male reproduction. Results: Compared with the normal group, the mice with VD deficiency had lower sperm concentration[(128±53) ×10(6)/ml vs( 58±15) ×10(6)/ml, P <0...
December 11, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Han-Joo Maeng, Trang Nguyen Kieu Doan, In-Soo Yoon
1α,25-Dihydroxyvitamin D3 (also called 1,25(OH)2 D3 or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR). It was previously reported that intestinal cytochrome P450 3A (CYP3A) expression was altered by 1,25(OH)2 D3 -mediated VDR activation. However, to clarify whether the change in CYP3A subfamily expression by VDR activation can affect metabolic function, further evidence is needed to prove the effect of 1,25(OH)2 D3 treatment on CYP3A-mediated drug metabolism and pharmacokinetics...
December 10, 2018: Drug Development Research
Mellar P Davis, Rajiv Panikkar
Clinicians often believe that cachexia is caused by cancer and anorexia as a toxicity of chemotherapy or targeted anti-cancer agents. It is now recognized that chemotherapy and certain targeted agents cause sarcopenia which reduce physical function and quality of life. Pre-treatment sarcopenia predicts chemotherapy toxicity, reduced response, increased disability, poor anti-tumor response and survival. Though bioelectrical impedance and dual energy X-ray absorptiometry (DEXA) scans have been used in the past for body composition measurements, CT scan cuts at the level of the 3rd lumbar vertebral body with measurement of skeletal muscle and visceral and subcutaneous fat areas has become standard...
September 7, 2018: Annals of Palliative Medicine
Leila Hadjadj, Anna Monori-Kiss, Eszter M Horváth, Andrea Heinzlmann, Attila Magyar, Réka E Sziva, Zsuzsanna Miklós, Éva Pál, János Gál, István Szabó, Zoltán Benyó, György L Nádasy, Szabolcs Várbíró
Vitamin D (VitD) hypovitaminosis and androgen excess (AE) are both risk factors for cardiovascular diseases in fertile women. However, the possible early interaction between AE and VitD status is not clear. Our goal was to describe how VitD status influences early changes in the biomechanical reactivity of small coronary arterioles in adult female rats after transdermal testosterone treatment. Forty-six adolescent, 90-110-gram-weighed female Wistar rats were randomly grouped into 4 groups. Twenty-four animals received an optimal VitD-supplemented diet, from which 12 animals underwent transdermal testosterone treatment...
November 28, 2018: Microvascular Research
Vibha Singhal, Kathryn E Ackerman, Amita Bose, Landy Paola Torre Flores, Hang Lee, Madhusmita Misra
Objective: Transdermal, but not oral, estrogen replacement improves bone mineral density (BMD) in athletes with oligo-amenorrhea (OA). Our objective was to determine mechanisms that may explain the impact of route of estrogen administration on bone outcomes. Methods: 73 OA between 14-25 years old received (i) a 17β-estradiol transdermal patch continuously with cyclic oral micronized progesterone (PATCH), (ii) a combined ethinyl estradiol and desogestrel pill (PILL), or (iii) no estrogen/progesterone (NONE) for 12-months...
November 23, 2018: Journal of Clinical Endocrinology and Metabolism
Elisabeth Lerchbaum, Christian Trummer, Verena Theiler-Schwetz, Martina Kollmann, Monika Wölfler, Annemieke C Heijboer, Stefan Pilz, Barbara Obermayer-Pietsch
PURPOSE: It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline. METHODS: The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria...
November 20, 2018: European Journal of Nutrition
John S Fitzgerald, Joanna Orysiak, Patrick B Wilson, Joanna Mazur-Różycka, Zbigniew Obminski
The identification of the vitamin D receptor in tissues related to testosterone and cortisol production, in conjunction with the observed correlations between vitamin D levels and these hormones in the general population, suggest vitamin D may influence testosterone and cortisol concentrations in athletes. A cross-sectional study design was used to evaluate the association between 25(OH)D and testosterone and cortisol concentrations in young male ice hockey players ( n = 50). All athletes were recruited during October from the Sosnowiec area, Poland (50° N)...
September 2018: Biology of Sport
Barbara Grzechocinska, Damian Warzecha, Iwona Szymusik, Janusz Sierdzinski, Mirosław Wielgos
INTRODUCTION: Vitamin D (VD) plays a crucial role in calcium metabolism as well as immunological and endocrine homeostasis. Previous studies revealed strong inverse correlation between VD levels and insulin resistance, parathyroid dysfunctions and autoimmune thyroid disease. Insufficient evidence concerns its dependency of ovarian hormones. Malfunctioning of the ovaries results in menstrual disorders that are one of the most common endocrine impairments in young women of reproductive age...
September 4, 2018: Neuro Endocrinology Letters
Forough Saki, Seyed Reza Kasaee, Faezeh Sadeghian, Pedram Talezadeh, Gholam Hossein Ranjbar Omrani
Testosterone is an essential hormone to maintain bone integrity; however, the effect of aromatase enzyme in androgen-induced bone maintenance remains somewhat unclear. The present study evaluated the effect of testosterone itself and combined with letrozole, an aromatase inhibitor, on bone mineral density of male rats. Total of 48 male rats were divided into 4 equal groups (n = 12/group); sham group, O: orchiectomy, O + T: orchiectomized rats treated with testosterone, O + T + L: orchiectomized rats treated with combination of testosterone and letrozole...
November 3, 2018: Journal of Bone and Mineral Metabolism
Rehana Rehman, Salima Lalani, Mukhtiar Baig, Iman Nizami, Zohaib Rana, Zohair Jamil Gazzaz
Background: The prevalence of infertility and vitamin D deficiency is common in Pakistan. Therefore, our study aims were to assess and compare Vitamin D; 25-hydroxyvitamin (25OHD) and reproductive hormone levels in male fertile and infertile subjects with normal and abnormal sperm parameters. Furthermore, the study is aimed to explore the association of 25OHD levels with these sperm parameters in a selected population of Karachi, Pakistan. Methods: The cross-sectional study was carried out from August 2016 till December 2017, 313 study subjects were recruited from an Infertile Clinic from Islamabad, Pakistan, and the general population...
2018: Frontiers in Endocrinology
Nicola Keay, Gavin Francis, Karen Hind
Objectives: To evaluate the efficacy of a sport-specific energy availability (EA) questionnaire, combined with clinical interview, for identifying male athletes at risk of developing bone health, endocrine and performance consequences of relative energy deficiency in sports (RED-S). Methods: Fifty competitive male road cyclists, recruited through links of participants in a pilot study, were assessed by a newly developed sport-specific questionnaire and clinical interview (SEAQ-I) and received dual energy X-ray absorptiometry (DXA) bone mineral density (BMD) and body composition scans and blood tests for endocrine markers...
2018: BMJ Open Sport & Exercise Medicine
Andrea Olmos-Ortiz, Janice García-Quiroz, Ali Halhali, Euclides Avila, Verónica Zaga-Clavellina, Roberto Chavira-Ramírez, Rocío García-Becerra, Felipe Caldiño-Soto, Fernando Larrea, Lorenza Díaz
Clinical and epidemiological evidence supports that pregnancies carrying a male fetus are more vulnerable to infections and preterm birth, probably due to testosterone immunosuppressive properties. In human placentas, testosterone lowers the expression of CYP27B1, the vitamin D (VD)-activating enzyme, diminishing cathelicidin synthesis, a potent VD-dependent antimicrobial peptide (AMP). VD also stimulates other AMPs, including defensins. To get insights into the increased male vulnerability mechanisms, we investigated the relationship between fetal sex and the immunoendocrine milieu at the fetoplacental unit...
October 22, 2018: Journal of Steroid Biochemistry and Molecular Biology
Bryan C Jiang, Dennis T Villareal
PURPOSE OF REVIEW: Obesity rates worldwide continue to increase and will disproportionately affect older adults because of population aging. This review highlights recent progress pertaining to therapeutic approaches to obesity in older adults. RECENT FINDINGS: Caloric restriction alone improves physical function and quality of life in older adults with obesity but is associated with loss of lean mass and increases fracture risk. Adding progressive resistance training to caloric restriction attenuates loss of muscle and bone mass and increasing protein intake enhances this effect...
January 2019: Current Opinion in Clinical Nutrition and Metabolic Care
Suna Kılınç, Enver Atay, Ömer Ceran, Zeynep Atay
CONTEXT: The effects of Vitamin D on reproductive function in adults have gained interest. Studies have demonstrated some associations. Hypothalamic-pituitary-gonadal axis is activated during the first 6 months of life, called as mini-puberty. This HPG activation is important for future gonadal function. There is no data regarding the association of gonadal hormones and 25(OH)D levels at mini-puberty. Demonstration of any association would form the basis for studies that will search for the effects of 25(OH)D on gonadal hormones at mini-puberty...
September 19, 2018: Clinical Endocrinology
Jussi Mäkinen, Sirpa Rainesalo, Jani Raitanen, Jukka Saarinen, Satu Sandell, Jukka Peltola
Objective: Treatment with carbamazepine (CBZ), a potent enzyme inducer, is known to affect the lipid profile, steroid, and vitamin D metabolism. Consequently, it has been postulated that patients on CBZ should be switched to noninducing antiepileptic drugs (AEDs). However, little is known about the seizure outcome following a CBZ switch in seizure-free patients. We aimed to address this issue using a controlled observational study design. Methods: Fifty-eight patients taking CBZ for focal epilepsy were assessed for discontinuing CBZ treatment due to concerns of long-term adverse-effects; 34 discontinued its therapy and 24 continued with CBZ...
September 2018: Epilepsia open
Chao-Yun Wang, Juan-Juan Zhang, Peng Duan
Objective: To explore the antagonistic effect of vitamin E (VE) on male reproductive toxicity induced by di-2-ethylhexyl phthalate (DEHP) in pubertal SD rats and its underlying mechanisms. METHODS: Thirty 5-week-old male SD rats were randomly divided into five groups of equal number, corn oil control, low-dose (10 mg/kg/d), medium-dose (100 mg/kg/d) and high-dose DEHP exposure (500 mg/kg/d), and VE intervention (high-dose DEHP + VE [100 mg/kg/d]), and treated respectively for 30 successive days...
July 2018: Zhonghua Nan Ke Xue, National Journal of Andrology
David R Weber, Shiny Thomas, Stephen W Erickson, Deborah Fox, Joyce Oleszek, Shree Pandya, Yedatore Venkatesh, Christina Westfield, Emma Ciafaloni
BACKGROUND: Patients with Duchenne muscular dystrophy (DMD) are at high risk of endocrine and bone health complications resulting from the high glucocorticoid (GC) doses used to treat this condition. There are limited data characterizing the clinical management of these complications. OBJECTIVE: To determine the frequency of bone health screening, endocrinologist evaluation, and use of endocrine and bone health pharmacotherapy in the clinical care of males with DMD...
2018: Journal of Neuromuscular Diseases
Robert A Huggins, Andrea R Fortunati, Ryan M Curtis, David P Looney, Chris A West, Elaine C Lee, Maren S Fragala, Mathew L Hall, Douglas J Casa
Huggins, RA, Fortunati, AR, Curtis, RM, Looney, DP, West, CA, Lee, EC, Fragala, MS, Hall, ML, and Casa, DJ. Monitoring blood biomarkers and training load throughout a collegiate soccer season. J Strength Cond Res XX(X): 000-000, 2018-This observational study aimed to characterize the responses of a comprehensive panel of biomarkers, observed ranges, training load (TL) metrics, and performance throughout the collegiate soccer season (August-November). Biomarkers (n = 92) were collected before the start of pre-season (PS), in-season weeks (W)1, W4, W8, and W12 in NCAA Division I male soccer players (n = 20, mean ± SD; age = 21 ± 1 years, height = 180 ± 6 cm, body mass = 78...
August 2, 2018: Journal of Strength and Conditioning Research
Anton De Spiegeleer, David Beckwée, Ivan Bautmans, Mirko Petrovic
BACKGROUND: Sarcopenia, defined as the pathological decline in muscle mass, muscle strength and physical performance with aging, has become one of the geriatric giants because of its increasing prevalence and devastating health effects. The Belgian Society of Gerontology and Geriatrics (BSGG) is currently developing evidence-based guidelines for the prevention and therapy of sarcopenia for use in broad clinical practice. This systematic review summarizes the results of the Working Group on Pharmacology...
August 2018: Drugs & Aging
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"