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Isabel Rauscher, Matthias Eiber, Wolfgang A Weber, Jürgen E Gschwend, Thomas Horn, Tobias Maurer
Positron-emission tomography/computed tomography combining both functional and morphological information has emerged as a powerful tool in oncological imaging within the past decades. The most commonly used radiotracer in oncology visualizing metabolic information is 2-[18F]fluoro-2-deoxy-d-glucose. However, the use of 2-[18F]fluoro-2-deoxy-d-glucose in urological oncology is challenging, as it is limited by physiological excretion through the urinary system. Therefore, it is only useful when applied to specific indications in selected patients with urological malignancy; for example, for detection of residual disease in the post-chemotherapy management of patients with seminoma...
August 13, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
Ming Liu, Julia Y S Tsang, Michelle Lee, Yun-Bi Ni, Siu-Ki Chan, Sai-Yin Cheung, Jintao Hu, Hong Hu, Gary M K Tse
AIMS: In breast cancer models, the functional roles of CD147 in proliferation, invasion and treatment resistance have been widely reported. However, there are only a few studies examining the clinicopathological correlation and prognostic relevance of CD147 in breast cancer, especially in relation to breast cancer molecular subtypes. METHODS: In this study, we analysed CD147 expression in a large cohort of breast cancers, correlating with clinicopathological features and the expression of a comprehensive panel of biomarkers in triple-negative breast cancer (TNBC) and non-TNBC subsets...
August 11, 2018: Journal of Clinical Pathology
John Eckstrom, Trace Bartels, Ivo Abraham, Hitendra Patel, Emad Elquza, Aaron J Scott, Steven Malangone, Jerrelee Hollings, Ali McBride
BACKGROUND: Practice patterns of same-day versus next-day pegfilgrastim vary in numerous practice settings across the country. Current utilization with same-day pegfilgrastim reduced overall visits and reduced treatment time for chemotherapy administration. OBJECTIVE: To assess the efficacy and safety of same-day versus next-day pegfilgrastim in patients with colorectal cancer. METHODS: Patient data was extracted through electronic health records (EHR) search of ICD-9 codes that matched patients with CRC and treated with FOLFOX or FOLFIRI from November 2013 to January 2016...
August 8, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
N Sinha, J M Letourneau, K Wald, P Xiong, Tal Imbar, B Li, E Harris, E Mok-Lin, M I Cedars, Mitchell P Rosen
PURPOSE: After chemotherapy for breast cancer, most women will recover some ovarian function, but the timing and extent of this recovery are poorly understood. We studied post-chemotherapy ovarian recovery in women with and without a history of ovarian suppression during chemotherapy. METHODS: Reproductive age breast cancer patients who were seen prior to chemotherapy for fertility preservation consult were consented for follow-up ovarian function assessment (every 3-6 months after chemotherapy) with antral follicle count (AFC) in this prospective cohort study...
July 31, 2018: Journal of Assisted Reproduction and Genetics
Rui Mao, Jian-Jun Zhao, Xin-Yu Bi, Ye-Fan Zhang, Zhi-Yu Li, Zhen Huang, Jian-Guo Zhou, Hong Zhao, Jian-Qiang Cai
BACKGROUND: The neutrophil to lymphocyte ratio (NLR) is a marker of inflammation and is associated with poor outcomes. We aimed to evaluate the role of the pretreatment NLR in predicting the outcomes after preoperative chemotherapy in patients with colorectal liver metastases (CRLM). METHODS: A retrospective review was performed for 183 patients with CRLM. The NLR was measured before chemotherapy, and a receiver operating characteristic (ROC) curve was used to estimate the cutoff value...
July 31, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
J LaPorte, K Leone, X Zhang, K Holland, L Morris, A Bashey, M Solh, S Solomon
Myeloablative chemotherapy administered prior to autologous stem cell transplantation (auto-SCT) is associated with a significant amount of chemotherapy-induced nausea and vomiting (CINV). We conducted a phase II trial to assess the safety, efficacy, and impact on quality of life when palonosetron (PAL) 0.25 mg combined with dexamethasone were given on the final or only day of myeloablative chemotherapy for auto-SCT. The primary end point of this study was the incidence of achieving a delayed CINV complete response defined as no emetic episode and no use of rescue medications during the 24-120 h period post chemotherapy...
July 29, 2018: Journal of Oncology Pharmacy Practice
Teng-Kuan Wang, Fang-Ying Kuo, Shin-Yi Lee, Yu-Fan Cheng, Ahmed M Elsarawy, Chih-Che Lin, Ting-Lung Lin, Chao-Long Chen
The thymus gland possesses the ability to regrow in children leading to a newly developed anterior mediastinal mass. This condition may represent a rebound phenomenon during recovery from a stressful event such as post-chemotherapy and hence was described as RTH. RTH after LT has not been well documented. We are reporting an infant with BA who underwent LT and presented with a symptomless anterior mediastinal mass, detected on follow-up imaging 6 months thereafter. Surgical partial excision was performed to rule out other differential diagnoses of a solid mass in the anterior mediastinum of an infant particularly lymphoma-that may arise as post-transplant lymphoproliferative disorder-and teratoma, as well as the other aggressive lesions such as thymoma and thymic carcinoma...
July 24, 2018: Pediatric Transplantation
Hadil Onallah, Liora Jacobs Catane, Claes G Tropé, Thea E Hetland Falkenthal, Reuven Reich, Ben Davidson
The aim of this study was to analyze the expression, biological role and clinical relevance of autotaxin (ATX), the enzyme synthetizing lysophosphatidic acid (LPA), and LPA receptors (LPAR) in high-grade serous carcinoma (HGSC). mRNA expression by qRT-PCR of LPAR1-6 was analyzed in 155 HGSC specimens (88 effusions, 67 solid lesions). ATX mRNA expression was analyzed in 97 specimens. ATX, ERK, and AKT protein expression was studied by Western blotting. LPAR2 mRNA was overexpressed in HGSC cells in effusions compared to solid lesions, with opposite findings for LPAR3 and LPAR6 mRNA and ATX protein...
July 21, 2018: Virchows Archiv: An International Journal of Pathology
Shin Nishio, Satomi Aihara, Mototsugu Shimokawa, Akira Fujishita, Shuichi Taniguchi, Toru Hachisuga, Shintaro Yanazume, Hiroaki Kobayashi, Fumihiro Murakami, Fumitaka Numa, Kohei Kotera, Naofumi Okura, Naoyuki Toki, Masatoshi Yokoyama, Kimio Ushijima
OBJECTIVE: Palonosetron is effective for the management of acute and delayed chemotherapy-induced nausea and vomiting (CINV). While emetogenic carboplatin-based chemotherapy is widely used to treat gynecologic cancers, few studies have evaluated the antiemetic effectiveness of palonosetron in this setting. METHODS: A multicenter, single-arm, open-label phase II trial was conducted to evaluate the safety and effectiveness of palonosetron in controlling CINV in patients with gynecologic cancer...
September 2018: Journal of Gynecologic Oncology
J Th C M de Kruif, M B Scholtens, J van der Rijt, M R de Boer, M M G A van den Berg, Y C de Vries, R M Winkels, M Visser, E Kampman, M J Westerman
PURPOSE: Dutch Health care professionals (HCPs) provide little information concerning health risks associated with weight gain during chemotherapy for breast cancer. Women with breast cancer have specified the need for more information on nutrition and physical activity to deal with weight gain. The aims of this study were to assess the perceptions of Dutch HCPs on weight gain during chemotherapy and in addition evaluate whether and what kind of information on dietary intake and physical activity HCPs provide to prevent/treat weight gain during (neo)adjuvant chemotherapy...
July 19, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Kathleen M McCarten, Monika L Metzger, Richard A Drachtman, Qinglin Pei, Debra L Friedman, Cindy L Schwartz, Kara M Kelly
BACKGROUND: Pleural effusion at presentation in Hodgkin lymphoma has been associated with inferior outcome but has not been systematically evaluated. OBJECTIVE: To determine whether pleural effusion at presentation in children with Hodgkin lymphoma is a primary indicator of poor prognosis or secondary to associated factors. MATERIALS AND METHODS: Children's Oncology Group (COG) AHOD0031, a randomized, response-based, centrally reviewed protocol, enrolled 1,712 eligible patients <22 years of age with initial presentation of intermediate risk, biopsy-proven Hodgkin lymphoma; 1,423 had available imaging for retrospective review...
July 16, 2018: Pediatric Radiology
Hyun-Ah Kim, Jihye Choi, Chan Sub Park, Min-Ki Seong, Sungeun Hong, Jae-Sung Kim, In-Chul Park, Jin Kyung Lee, Woo Chul Noh
In the era of precision medicine, the prediction of ovarian function recovery from chemotherapy-induced amenorrhoea using feasible biological markers may be helpful to optimise the treatment strategy for young patients with hormone receptor-positive breast cancer. The purpose of this study was to investigate the accuracy of post-chemotherapy biological markers for predicting the recovery of ovarian function in breast cancer patients of the ASTRRA trial, with chemotherapy-induced amenorrhoea. Using data of 82 participants from a single institution in the ASTRRA trial, the post-chemotherapy serum levels of the anti-müllerian hormone (AMH), estradiol, inhibin B, and other clinical factors associated with chemotherapy-induced amenorrhoea were evaluated...
July 16, 2018: Endocrine Connections
Virender Sekhon, Manav Suryavanshi
INTRODUCTION: Intracaval extension is present in 4-11% of all Wilms' tumour (WT). We present the open surgical nuances of inferior vena cava (IVC) thrombectomy with nephroureterectomy in post-chemotherapy WT. METHODS: A 10-year-old girl with right WT and intracaval tumour thrombus presented for surgical resection after six cycles of chemotherapy (vincristine, actinomycin D). A preoperative assessment plan of the vascular anatomy of the tumour was done. Meticulous intraoperative handling of the tumour mass, overcoming chemotherapy-induced fibrosis during inter-aortocaval groove dissection, optimal hemodynamic control during venotomy, en bloc resection of tumour with intracaval thrombus, and repair of the IVC are detailed...
July 2, 2018: Journal of Pediatric Urology
Maja Raicevic, Amulya K Saxena
BACKGROUND: This study systematically reviewed etiology, prevalence, treatment and outcome of Barrett's esophagus (BE) in the pediatric population. METHODS: PubMed® was searched for terms "Barrett's esophagus" and "children". End points were age of patients, etiology, association with other syndromes, treatment, incidence of carcinoma and outcome. This review was conducted according to the PRISMA guidelines. Data were collected, entered and analyzed into a Microsoft Excel® spreadsheet database...
July 10, 2018: World Journal of Pediatrics: WJP
Kazuhiro Horiuchi, Yasunori Maruo, Satomi Matsuoka
We herein report the case of stiff-person syndrome in a 73-year-old woman. She experienced episodes of painful muscle spasms and was admitted to another hospital. She was diagnosed with Waldenström macroglobulinemia. She showed improvement in muscle spasms post-chemotherapy, which was discontinued due to pancytopenia. Six months later, she was admitted to our hospital for repeated whole-body muscle spasms, at which point she was diagnosed with stiff-person syndrome. An anti-glutamic acid decarboxylase antibody text was negative...
July 6, 2018: Internal Medicine
Ryan P Werntz, Shane M Pearce, Scott E Eggener
PURPOSE OF REVIEW: Examine and discuss indications, technique, and outcomes for robotic retroperitoneal lymph node dissection (RPLND) for testicular cancer. RECENT FINDINGS: Open RPLND has been the longstanding standard of care for both primary and post chemotherapy RPLND. Recently, robotic RPLND has been an attractive option with the intent of reducing the morbidity associated with open surgery while providing identical oncologic efficacy. Naysayers of robotic RPLND suggest it is often inappropriately used as a staging procedure and consequently can compromise oncologic efficacy...
September 2018: Current Opinion in Urology
Estherina Trachtenberg, Tatiana Mashiach, Rachel Ben Hayun, Tamar Tadmor, Tali Fisher, Judith Aharon-Peretz, Eldad J Dann
Cancer-related cognitive impairment (CRCI) is commonly reported post-chemotherapy in adults with solid tumours. Hodgkin lymphoma (HL) mostly affects young adults. Data regarding CRCI in HL survivors (HLS) are scarce. The current study aimed to objectively assess CRCI incidence and characteristics in HLS. HLS, who completed first-line (chemotherapy ± radiation) therapy and remained in complete remission for 6 months to 5 years from therapy end, were evaluated. Age- and education-matched healthy individuals served as controls (n = 14)...
July 5, 2018: British Journal of Haematology
Safana A Al-Rawi, Basil O Saleh, Manwar A Al-Naqqash
OBJECTIVES: To investigate the role of serum anti müllerian hormone (AMH) pre-chemotherapy treatment levels in prediction of post-chemotherapy effect on the ovarian reserve of women with breast cancer. METHODS: This cohort prospective study was carried out at the Biochemistry Department, College of Medicine, University of Baghdad and at the Oncology Clinic, Oncology Teaching Hospital, Baghdad, Iraq. It included 58 women with regular menstrual cycle (25-45 years) who were  newly diagnosed with breast cancer...
July 2018: Saudi Medical Journal
Roberta Kiffin, Hanna Grauers Wiktorin, Malin S Nilsson, Johan Aurelius, Ebru Aydin, Brianna Lenox, Jonas A Nilsson, Anders Ståhlberg, Fredrik B Thorén, Kristoffer Hellstrand, Anna Martner
In patients with acute myeloid leukemia (AML), treatment with histamine dihydrochloride (HDC) and low-dose IL-2 (HDC/IL-2) in the post-chemotherapy phase has been shown to reduce the incidence of leukemic relapse. The clinical benefit of HDC/IL-2 is pronounced in monocytic forms of AML, where the leukemic cells express histamine type 2 receptors (H2 R) and the NAPDH oxidase-2 (NOX2). HDC ligates to H2 Rs to inhibit NOX2-derived formation of reactive oxygen species, but details regarding the anti-leukemic actions of HDC remain to be elucidated...
2018: Frontiers in Oncology
Jun-Ting Lv, Zhi-Gang Yang, You-Hong Guang, Zhong-Shun Lin, Xing-Xian Xiao, De Liu, Man Shi, Wen-Shan Wang
OBJECTIVE: To investigate the presence of leukemia stem cells (LSC) in acute myeloid leukemia (AML) and find out the relative position of leukemia cells in the figures of flow cytometry, and to analyze the relationship between minimal residual diseases (MRD) and the level of LSC, so as to explore the correlation of LSC changes with the curative effect and the prognosis during chemical therapy. METHODS: A total of 85 samples were collected from 50 AML (except M3) patients, including 50 samples from the newly diagnosed patients, 7 samples of AML patients with non-remission and 28 samples of AML patients with complete remission...
June 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
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