keyword
https://read.qxmd.com/read/38526621/optimal-timing-of-prophylactic-pegylated-g-csf-after-chemotherapy-administration-for-patients-with-cancer-a-systematic-review-and-meta-analysis-from-clinical-practice-guidelines-for-the-use-of-g-csf-2022
#1
JOURNAL ARTICLE
Yukinori Ozaki, Takamichi Yokoe, Tetsuhiro Yoshinami, Kazuki Nozawa, Hiroshi Nishio, Kenji Tsuchihashi, Eiki Ichihara, Yuji Miura, Makoto Endo, Shingo Yano, Dai Maruyama, Nobuyuki Susumu, Munetaka Takekuma, Takashi Motohashi, Mamoru Ito, Eishi Baba, Nobuaki Ochi, Toshio Kubo, Keita Uchino, Takahiro Kimura, Yutaro Kamiyama, Shinji Nakao, Shinobu Tamura, Hitomi Nishimoto, Yasuhisa Kato, Atsushi Sato, Toshimi Takano
INTRODUCTION: The timing of prophylactic pegylated granulocyte colony-stimulating factor (G-CSF) administration during cancer chemotherapy varies, with Day 2 and Days 3-5 being the most common schedules. Optimal timing remains uncertain, affecting efficacy and adverse events. This systematic review sought to evaluate the available evidence on the timing of prophylactic pegylated G-CSF administration. METHODS: Based on the Minds Handbook for Clinical Practice Guideline Development, we searched the PubMed, Ichushi-Web, and Cochrane Library databases for literature published from January 1990 to December 2019...
March 25, 2024: International Journal of Clinical Oncology
https://read.qxmd.com/read/38508973/correlation-of-ct-scan-response-to-necrosis-and-volume-changes-with-histopathology-in-children-with-wilms-tumor
#2
JOURNAL ARTICLE
Niaz Nilave, Sajida Nahid, Saiyeda Karim, Shahnoor Islam, Amirul Morshed
BACKGROUND: Wilms' tumor is the most common renal tumor in children. OBJECTIVE: To correlate the percentage of necrosis and tumor volume change found in preoperative Contrast Enhance Computed Tomography (CECT) scan of the abdomen with post-operative histopathological findings of Wilms Tumor (WT). METHODS: In this prospective study from January 2020 to December 2022, out of 33 patients, 15 patients with unilateral localized WT (stage I, II, and III) treated according to SIOP UMBRELLA protocol 2016 were included...
February 27, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38504770/bevacizumab-induced-pulmonary-cystic-disease
#3
Dakota McNierney, Fahed Owda, Hamza A Salim, Shatha M A Mallah, Jehad Azar
The use of Bevacizumab has significantly advanced the treatment of various malignancies. Bevacizumab's inhibition of angiogenesis is a known mechanism that impedes tumour growth and facilitates chemotherapy delivery; however, its association with the development of cystic lung disease is not fully understood. We report a unique case of a 73-year-old woman with a past medical history of metastatic endometrial adenocarcinoma status post-chemotherapy with bevacizumab that presented with worsening respiratory symptoms...
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38495643/identifying-central-symptom-clusters-and-correlates-in-patients-with-lung-cancer-post-chemotherapy-a-network-analysis
#4
JOURNAL ARTICLE
Liping Teng, Zhou Zhou, Yiting Yang, Jun Sun, Yajun Dong, Min Zhu, Teng Wang
OBJECTIVE: This study aims to investigate the network structures of symptoms and symptom clusters in patients with lung cancer post-chemotherapy, with a focus on identifying the central symptom cluster. Understanding the central cluster is crucial for targeted and effective symptom management. METHODS: Symptom occurrence and severity were assessed using the Memorial Symptom Assessment Scale (MSAS). Principal component analysis (PCA) was employed to explore symptom clusters, while network analysis unveiled the network structure and pinpointed the central symptom cluster...
April 2024: Asia-Pacific Journal of Oncology Nursing
https://read.qxmd.com/read/38491128/evaluating-persistent-t1-weighted-lesions-without-concurrent-abnormal-enhancement-on-breast-mri-in-neoadjuvant-chemotherapy-patients-implications-for-complete-pathological-response
#5
JOURNAL ARTICLE
Shahine Goulam-Houssein, Xiang Y Ye, Rachel Fleming, Frederick Au, Supriya Kulkarni, Sandeep Ghai, Yoav Amitai, Michael Reedijk, Vivianne Freitas
OBJECTIVE: This study aims to determine whether persistent T1-weighted lesions signify a complete pathological response (pCR) in breast cancer patients treated with neoadjuvant chemotherapy and surgery, and to evaluate their correlation with imaging responses on MRI. MATERIALS AND METHODS: A retrospective review was conducted on data from breast cancer patients treated between January 2011 and December 2018. Patients who underwent breast MRI and pre- and post-neoadjuvant chemotherapy followed by surgery were included...
March 16, 2024: European Radiology
https://read.qxmd.com/read/38470132/therapeutic-vaccines-for-advanced-non-small-cell-lung-cancer
#6
REVIEW
Marcela Cortés-Jofré, Mikel Rueda-Etxebarria, Emeline Orillard, Elena Jimenez Tejero, José-Ramón Rueda
BACKGROUND: New strategies in immunotherapy with specific antigens that trigger an anti-tumour immune response in people with lung cancer open the possibility of developing therapeutic vaccines aimed at boosting the adaptive immune response against cancer cells. OBJECTIVES: To evaluate the effectiveness and safety of different types of therapeutic vaccines for people with advanced non-small cell lung cancer. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, Wanfang Data, and China Journal Net (CNKI) up to 22 August 2023...
March 12, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38465622/dynamic-evolution-of-bone-marrow-adipocyte-in-b-cell-acute-lymphoblastic-leukemia-insights-from-diagnosis-to-post-chemotherapy
#7
JOURNAL ARTICLE
Xi Jia, Naying Liao, Yunqian Yao, Xutao Guo, Kai Chen, Pengcheng Shi
Adipocyte is a unique and versatile component of bone marrow microenvironment (BMM). However, the dynamic evolution of Bone Marrow (BM) adipocytes from the diagnosis of B cell Acute Lymphoblastic Leukemia (B-ALL) to the post-treatment state, and how they affect the progression of leukemia, remains inadequately explicated. Primary patient-derived xenograft models (PDXs) and stromal cell co-culture system are employed in this study. We show that the dynamic evolution of BM adipocytes from initial diagnosis of B-ALL to the post-chemotherapy phase, transitioning from cellular depletion in the initial leukemia niche to a fully restored state upon remission...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38461265/multi-omics-analysis-of-the-gut-microbiome-and-metabolites-associated-with-the-psychoneurological-symptom-cluster-in-children-with-cancer-receiving-chemotherapy
#8
JOURNAL ARTICLE
Jinbing Bai, Ronald Eldridge, Madelyn Houser, Melissa Martin, Christie Powell, Kathryn S Sutton, Hye In Noh, Yuhua Wu, Thomas Olson, Konstantinos T Konstantinidis, Deborah W Bruner
BACKGROUND: Children with cancer receiving chemotherapy commonly report a cluster of psychoneurological symptoms (PNS), including pain, fatigue, anxiety, depression, and cognitive dysfunction. The role of the gut microbiome and its functional metabolites in PNS is rarely studied among children with cancer. This study investigated the associations between the gut microbiome-metabolome pathways and PNS in children with cancer across chemotherapy as compared to healthy children. METHODS: A case-control study was conducted...
March 9, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38455694/aplastic-anaemia-associated-with-bendamustine-therapy-a-rare-side-effect
#9
JOURNAL ARTICLE
Salman Khan, Ekrem Yetiskul, Malik Waleed Zeb Khan, Gabriel Chavez Reyna, Amanda Matra, Georges Khattar, Marcel A Odaimi
INTRODUCTION: During treatment for malignant lymphoma, cytopenia can develop for several reasons. This can range from mild cytopenias leading to infection and bleeding to full-blown drug-induced aplastic anaemia. While aplastic anaemia affects individuals of all genders and ages, here, we describe aplastic anaemia after chemotherapy exposure to bendamustine in a 65-year-old female with non-Hodgkin's lymphoma. CASE DESCRIPTION: A 65-year-old woman with recurrent indolent marginal zone lymphoma and post-chemotherapy with bendamustine and rituximab, presented with a neutropenic fever and was admitted with a leading diagnosis of sepsis...
2024: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38448600/cell-cycle-inhibition-and-immune-microenvironment-in-breast-cancer-treated-with-ribociclib-and-letrozole-or-chemotherapy
#10
JOURNAL ARTICLE
Tomás Pascual, Aranzazu Fernandez-Martinez, Yash Agrawal, Adam D Pfefferle, Nuria Chic, Fara Brasó-Maristany, Blanca Gonzàlez-Farré, Laia Paré, Guillermo Villacampa, Cristina Saura, Cristina Hernando, Montserrat Muñoz, Patricia Galván, Xavier Gonzàlez-Farré, Mafalda Oliveira, Miguel Gil-Gil, Eva Ciruelos, Patricia Villagrasa, Joaquín Gavilá, Aleix Prat, Charles M Perou
In this study, we performed genomic analyses of cell cycle and tumor microenvironment changes during and after ribociclib and letrozole or chemotherapy in the CORALLEEN trial. 106 women with untreated PAM50-defined Luminal B early breast cancers were randomly assigned to receive neoadjuvant ribociclib and letrozole or standard-of-care chemotherapy. Ki67 immunohistochemistry, tumor-infiltrating lymphocytes quantification, and RNA sequencing were obtained from tissue biopsies pre-treatment, on day 14 of treatment, and tumor specimens from surgical resection...
March 6, 2024: NPJ Breast Cancer
https://read.qxmd.com/read/38443704/role-of-upfront-autologous-transplant-for-peripheral-t-cell-lymphoma-patients-achieving-a-complete-remission-with-first-line-therapy-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
L Girard, Y J Koh, L P Koh, Y L Chee, H L Chan, J Lee, S de Mel, L M Poon, M Samuel
There is currently no consensus on the role of upfront autologous transplantation (ASCT) for patients with peripheral T-cell lymphomas (PTCL), especially in patients achieving first complete remission (CR1) following chemotherapy, and data in the literature is conflicting. A systematic review and meta-analysis was performed to address this question. We searched key databases from January 2000 to February 2022. Six prospective and eleven retrospective studies were included among 2959 unique records. Median follow up in these studies ranged from 22 to 94 months...
March 5, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38433125/characteristics-of-nausea-and-its-impact-on-health-related-quality-of-life-in-cisplatin-treated-patients-receiving-dexamethasone-sparing-prophylaxis-an-analysis-of-the-lung-nepa-study
#12
JOURNAL ARTICLE
Luigi Celio, Matti Aapro
PURPOSE: We investigated the intensity and duration of nausea as well as its impact on health-related quality of life among cisplatin-treated patients who participated in a study of dexamethasone (DEX)-sparing regimens based on NEPA (netupitant/palonosetron). METHODS: This retrospective analysis included chemo-naive patients from a trial evaluating non-inferiority of DEX on day 1 (DEX1 arm) combined with NEPA, compared with the same regimen with DEX administered on days 1-4 (DEX4; reference arm) following cisplatin (≥ 70 mg/m2 ) administration...
March 4, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38430167/comparative-safety-assessment-of-high-and-low-doses-of-anlotinib-in-combination-with-pd-1-monoclonal-antibody-for-advanced-non-small-cell-lung-cancer-patients
#13
JOURNAL ARTICLE
Lin Wan, Yan Xu, Liqiong Liu, Hui Huang
BACKGROUND: The advent of immunotherapy has revolutionized non-small cell lung cancer (NSCLC) treatment. Anlotinib (AN), a multitargeted tyrosine kinase inhibitor, holds promise in combination with PD-1 monoclonal antibody therapy. Understanding the impact of optimal dosage is pivotal. OBJECTIVE: This study aims to assess the comparative efficacy of high-dose AN versus low-dose AN when combined with PD-1 monoclonal antibody for the treatment of NSCLC. METHODS: A total of 70 patients with NSCLC undergoing PD-1 monoclonal antibody therapy at our hospital from June 2020 to January 2022 were selected...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38427145/pre-hepatectomy-dynamic-circulating-tumor-dna-to-predict-pathologic-response-to-preoperative-chemotherapy-and-post-hepatectomy-recurrence-in-patients-with-colorectal-liver-metastases
#14
JOURNAL ARTICLE
Ming Liu, Quan Bao, Tingting Zhao, Longfei Huang, Danhua Zhang, Yanyan Wang, Xiaoluan Yan, Hongwei Wang, Kemin Jin, Wei Liu, Kun Wang, Baocai Xing
OBJECTIVE: To evaluate the predictive value of pre-hepatectomy dynamic circulating tumor DNA (ctDNA) on pathologic response to preoperative chemotherapy and recurrence after liver resection for colorectal liver metastases (CRLM). BACKGROUND: Pathologic response is a predictor of clinical outcomes for patients undergoing hepatectomy for CRLM. Postoperative ctDNA has been proven to be sensitive for recurrence detection. However, few studies investigate the impact of pre-hepatectomy ctDNA on pathologic response and recurrence...
March 1, 2024: Hepatology International
https://read.qxmd.com/read/38418191/-effect-of-venetoclax-plus-chemotherapy-on-treatment-naive-acute-myeloid-leukemia-patients-with-moderate-to-poor-cytogenetic-profiles-and-the-combination-s-influence-on-the-expression-of-proteins-of-the-anti-apoptoic-family
#15
RANDOMIZED CONTROLLED TRIAL
(no author information available yet)
Objective: This was an open-label observational assessment aimed to evaluate whether venetoclax (VEN) plus chemotherapy could enhance the therapeutic benefits for treatment-naive acute myeloid leukemia (AML) patients with adverse cytogenetic profiles. Methods: A total of 38 adult patients (including 11 patients with moderate risk stratification and 27 patients with high risk stratification) who were treated at the Affiliated Hospital of Inner Mongolia Medical University from April 2019 to May 2022 were enrolled in this study...
February 23, 2024: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://read.qxmd.com/read/38415234/grossing-to-reporting-of-wilms-tumor-with-emphasis-on-proper-sampling-in-treatment-naive-and-postchemotherapy-specimens-and-their-clinicopathological-correlation-with-outcome
#16
JOURNAL ARTICLE
Mohan Krishna Pasam, B Vishal Rao, Sai Kiran Chaganty, Rakesh Manilal Sharma, Veerendra Patil, Suseela Kodandapani, Sundaram Challa, Subramanyeshwar Rao Thammineedi
CONTEXT: Emphasis on grossing to reporting for the assessment of histopathological parameters predicting outcomes in Wilms tumor. AIMS: To analyze various clinicopathological parameters that effect outcomes in treatment naïve and post chemotherapy Wilms tumor specimens. SETTINGS AND DESIGN: This was a retrospective observational study. SUBJECTS AND METHODS: All patients diagnosed with Wilms tumor between 2012 and 2018 at our institute will be included with their clinical findings, laboratory reports, and radiological findings...
2024: Urology Annals
https://read.qxmd.com/read/38410545/suppression-of-znf205-as1-egr4-positive-feedback-loop-attenuates-cisplatin-resistance-of-non-small-cell-lung-cancer-cells-via-targeting-mir-138-5p-oct4-pathway
#17
JOURNAL ARTICLE
Haiyan Li, Yingying Jin, Yefei Zhu, Bingxiao Shen, Youzu Xu
BACKGROUND: Long non-coding RNAs (lncRNAs) are frequently reported to involve in the onset and development of non-small cell lung cancer (NSCLC). Cisplatin (DDP) resistance continues to pose a daunting challenge for improving the prognosis of NSCLC patients. The current study intends to elucidate the molecular mechanisms underlying the function of lncRNA ZNF205 AS1/early growth response 4 (EGR4) positive feedback loop in DDP resistance of NSCLC. METHODS: A series of assays, including real-time polymerase chain reaction (PCR), western blotting, flow cytometry, and dual-luciferase reporter, were performed to evaluate the effect of ZNF205-AS1/EGR4 loop in the established DDP-resistant A549 cell line and its progenitor A549 cell line...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38403501/the-crossroads-of-cancer-therapies-and-clonal-hematopoiesis
#18
JOURNAL ARTICLE
Abhay Singh, Suresh Balasubramanian
The intricate interplay between Clonal Hematopoiesis (CH) and the repercussions of cancer therapies has garnered significant research focus in recent years. Previously perceived as an age-related phenomenon, CH is now closely linked to inflammation ("Inflammaging") and cancer, impacting leukemogenesis, cancer progression, and treatment responses. This review explores the complex interplay between CH and diverse cancer therapies, including chemotherapy, targeted treatments, radiation, stem cell transplants, CAR-T cell therapy, and immunotherapy, like immune checkpoint inhibitors...
January 18, 2024: Seminars in Hematology
https://read.qxmd.com/read/38392578/the-impact-of-chemotherapy-and-transforming-growth-factor-%C3%AE-1-in-liver-regeneration-after-hepatectomy-among-colorectal-cancer-patients
#19
JOURNAL ARTICLE
Rokas Račkauskas, Raminta Lukšaitė-Lukštė, Rokas Stulpinas, Augustinas Baušys, Marius Paškonis, Mindaugas Kvietkauskas, Vitalijus Sokolovas, Arvydas Laurinavičius, Kęstutis Strupas
An ongoing debate surrounds the impact of chemotherapy on post-hepatectomy liver regeneration in patients with colorectal cancer liver metastases (CRLM), with unclear regulatory mechanisms. This study sought to delve into liver regeneration post-resection in CRLM patients, specifically examining the roles of hepatocyte growth factor (HGF) and transforming growth factor β1 (TGF-β1). In this longitudinal observational study, 17 patients undergoing major liver resection for CRLM and 17 with benign indications as controls were enrolled...
January 28, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38385045/longitudinal-assessment-of-chemotherapy-induced-brain-connectivity-changes-in-cerebral-white-matter-and-its-correlation-with-cognitive-functioning-using-the-gqi
#20
JOURNAL ARTICLE
Vincent Chin-Hung Chen, Wei Chuang, Yuan-Hsiung Tsai, Roger S McIntyre, Jun-Cheng Weng
OBJECTIVE: Breast cancer was the most prevalent type of cancer and had the highest incidence rate among women worldwide. The wide use of adjuvant chemotherapy might have a detrimental effect on the human brain and result in chemotherapy-related cognitive impairment (CICI) among breast cancer patients. Furthermore, prior to chemotherapy, patients reported cancer-related cognitive impairment (CRCI), which might be due to physiological factors or mood symptoms. The present longitudinal study aimed to investigate microstructural and macroscale white matter alterations by generalized q-sampling imaging (GQI)...
2024: Frontiers in Neurology
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