keyword
MENU ▼
Read by QxMD icon Read
search

Telomere AND aging

keyword
https://www.readbyqxmd.com/read/30511318/selenium-aging-and-aging-related-diseases
#1
REVIEW
Zhonglin Cai, Jianzhong Zhang, Hongjun Li
Selenium is an essential trace element in the human body and plays an important role in the body via selenoprotein, which contains selenium. Selenoproteins (glutathione peroxidase, thioredoxin reductase, methionine sulfoxide reductase1 and endoplasmic reticulum-selenoproteins, etc.) have antioxidant effects and are involved in regulating antioxidant activities. Aging is an inevitable process and is always accompanied by aging-related diseases. Reactive oxygen species are important initial factors in aging and aging-related diseases...
December 3, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/30509985/mother-child-transmission-of-epigenetic-information-by-tunable-polymorphic-imprinting
#2
Brittany L Carpenter, Wanding Zhou, Zachary Madaj, Ashley K DeWitt, Jason P Ross, Kirsten Grønbæk, Gangning Liang, Susan J Clark, Peter L Molloy, Peter A Jones
Genomic imprinting mediated by DNA methylation restricts gene expression to a single allele determined by parental origin and is not generally considered to be under genetic or environmental influence. Here, we focused on a differentially methylated region (DMR) of approximately 1.9 kb that includes a 101-bp noncoding RNA gene ( nc886 / VTRNA2-1 ), which is maternally imprinted in ∼75% of humans. This is unlike other imprinted genes, which demonstrate monoallelic methylation in 100% of individuals. The DMR includes a CTCF binding site on the centromeric side defining the DMR boundary and is flanked by a CTCF binding site on the telomeric side...
December 3, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30509719/rapid-shortening-of-leukocyte-telomeres-is-associated-with-poorer-pulmonary-function-among-healthy-adults
#3
Kanan Desai, Neville Berkman, Irit Cohen-Manheim, Ronit Sinnreich, Abraham Aviv, Jeremy D Kark
AIM: The study aimed to examine the association between leukocyte telomere length (LTL) attrition over 13 years (between mean age 30 and mean age 43) and lung function at mean age 50. MATERIALS & METHODS: In a longitudinal observational study LTL was determined twice on a population-based sample of 481 Jewish residents of Jerusalem at mean ages 30 and 43 years. Pulmonary function was determined at mean age 50 years. Multiple linear regression and multivariable ordinal logistic modeling were applied...
December 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/30507277/effects-of-competitive-triathlon-training-on-telomere-length
#4
Marcus Colon, Andrew Hodgson, Eimear Donlon, James Ej Murphy
Telomeres act as a mitotic clock and telomere related senescence has been linked to age related physiological decline. There is increasing evidence lifestyle factors can influence telomere length. The purpose of this study was to determine the effect of competitive triathlon training on telomere length. Seven competitive male triathletes and seven recreationally active males participated in the study. Relative telomere length was measured using quantitative polymerase chain reaction (qPCR). Physiological parameters key to athletic performance such as V̇O2 max, lactate threshold and running economy were also measured...
December 3, 2018: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/30504320/clinical-consequences-of-clonal-hematopoiesis-of-indeterminate-potential
#5
REVIEW
David P Steensma
Clonally restricted hematopoiesis is a common aging-associated biological state that predisposes to subsequent development of a hematological malignancy or cardiovascular death. Clonal expansion driven by leukemia-associated somatic mutations, such as DNMT3A , ASXL1 , or TET2 , is best characterized, but oligoclonality can also emerge without recognized leukemia-driver mutations, perhaps as a result of stochastic neutral drift. Murine models provide compelling evidence that a major mechanism of increased cardiovascular mortality in the context of clonal hematopoiesis is accelerated atherogenesis driven by inflammasome-mediated endothelial injury, resulting from proinflammatory interactions between endothelium and macrophages derived from circulating clonal monocytes...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30502407/mathematical-model-to-study-the-aging-of-the-human-follicle-according-to-the-telomerase-activity
#6
A M Portillo, E Varela, J A García-Velasco
The aim of this work is to study the aging rate at which human follicles reach the preovulatory state. To this end, both telomere length and telomerase activity effects on granulosa cells (GCs) aging has been studied. GCs are somatic cells which determine the development of the oocyte. A human preantral follicle takes approximately 85 days to achieve the preovulatory size, going through several stages (Gougeon, 1996). The telomere length of GCs of each class of follicles, during folliculogenesis, are modelled using a chemical master equation formalism similar to the one in Wesch et al...
November 28, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/30502348/induced-trf2-deletion-leads-to-aging-vascular-phenotype-in-mice-associated-with-arterial-telomere-uncapping-senescence-signaling-and-oxidative-stress
#7
R Garrett Morgan, Ashley E Walker, Daniel W Trott, Daniel R Machin, Grant D Henson, Kelly D Reihl, Richard M Cawthon, Eros L Denchi, Yu Liu, Samuel I Bloom, Tam T Phuong, Russell S Richardson, Lisa A Lesniewski, Anthony J Donato
Age-related vascular dysfunction in large elastic and resistance arteries is associated with reductions in microvascular perfusion and elevations in blood pressure. Recent evidence indicates that telomere uncapping-induced senescence in vascular cells may be an important source of oxidative stress and vascular dysfunction in aging, but the causal relationship between these processes has yet to be elucidated. To test this important unexplored hypothesis, we measured arterial senescence signaling and oxidative stress, carotid and mesenteric artery endothelium-dependent vasodilatory capacity, markers of mesenteric microvascular perfusion and endothelial glycocalyx deterioration, and blood pressure in a novel mouse model of Cre-inducible whole body Trf2 deletion and telomere uncapping...
November 28, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/30496493/differential-effects-of-endurance-interval-and-resistance-training-on-telomerase-activity-and-telomere-length-in-a-randomized-controlled-study
#8
Christian M Werner, Anne Hecksteden, Arne Morsch, Joachim Zundler, Melissa Wegmann, Jürgen Kratzsch, Joachim Thiery, Mathias Hohl, Jörg Thomas Bittenbring, Frank Neumann, Michael Böhm, Tim Meyer, Ulrich Laufs
Aims: It is unknown whether different training modalities exert differential cellular effects. Telomeres and telomere-associated proteins play a major role in cellular aging with implications for global health. This prospective training study examines the effects of endurance training, interval training (IT), and resistance training (RT) on telomerase activity and telomere length (TL). Methods and results: One hundred and twenty-four healthy previously inactive individuals completed the 6 months study...
November 28, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30488553/telomere-length-and-telomerase-activity-in-t-cells-are-biomarkers-of-high-performing-centenarians
#9
Enzo Tedone, Ejun Huang, Ryan O'Hara, Kimberly Batten, Andrew T Ludlow, Tsung-Po Lai, Beatrice Arosio, Daniela Mari, Woodring E Wright, Jerry W Shay
It is generally recognized that the function of the immune system declines with increased age and one of the major immune changes is impaired T-cell responses upon antigen presentation/stimulation. Some "high-performing" centenarians (100+ years old) are remarkably successful in escaping, or largely postponing, major age-related diseases. However, the majority of centenarians ("low-performing") have experienced these pathologies and are forced to reside in long-term nursing facilities. Previous studies have pooled all centenarians examining heterogeneous populations of resting/unstimulated peripheral blood mononuclear cells (PBMCs)...
November 28, 2018: Aging Cell
https://www.readbyqxmd.com/read/30488545/epigenomic-drivers-of-immune-dysfunction-in-aging
#10
REVIEW
Christine R Keenan, Rhys S Allan
Aging inevitably leads to reduced immune function, leaving the elderly more susceptible to infections, less able to respond to pathogen challenges, and less responsive to preventative vaccinations. No cell type is exempt from the ravages of age, and extensive studies have found age-related alterations in the frequencies and functions of both stem and progenitor cells, as well as effector cells of both the innate and adaptive immune systems. The intrinsic functional reduction in immune competence is also associated with low-grade chronic inflammation, termed "inflamm-aging," which further perpetuates immune dysfunction...
November 28, 2018: Aging Cell
https://www.readbyqxmd.com/read/30488497/leukocyte-telomere-length-in-patients-with-radiographic-knee-osteoarthritis
#11
Alejandro Mosquera, Ignacio Rego-Pérez, Francisco J Blanco, José Luis Fernández
Relative mean telomere sequence amount was determined by quantitative PCR (qPCR) of peripheral blood leukocyte (PBL) samples obtained at recruitment (n = 310) from individuals from the Osteoarthritis (OA) Initiative consortium. Knees were radiologically evaluated according to the Kellgren-Lawrence (KL) score, ranging from 0 to 4, considering a KL grade ≥ 2 as radiographic evidence of OA (n = 124). Telomere size decreased as baseline KL score increased, being significantly shorter in subjects with KL ≥2 (Mann-Whitney U-test, P < 0...
November 29, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/30482770/clinical-consequences-of-clonal-hematopoiesis-of-indeterminate-potential
#12
REVIEW
David P Steensma
Clonally restricted hematopoiesis is a common aging-associated biological state that predisposes to subsequent development of a hematological malignancy or cardiovascular death. Clonal expansion driven by leukemia-associated somatic mutations, such as DNMT3A , ASXL1 , or TET2 , is best characterized, but oligoclonality can also emerge without recognized leukemia-driver mutations, perhaps as a result of stochastic neutral drift. Murine models provide compelling evidence that a major mechanism of increased cardiovascular mortality in the context of clonal hematopoiesis is accelerated atherogenesis driven by inflammasome-mediated endothelial injury, resulting from proinflammatory interactions between endothelium and macrophages derived from circulating clonal monocytes...
November 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/30481549/telomere-length-and-redox-balance-in-master-endurance-runners-the-role-of-nitric-oxide
#13
Caio V Sousa, Samuel S Aguiar, Patrick A Santos, Lucas P Barbosa, Beat Knechtle, Pantelis T Nikolaidis, Lysleine A Deus, Marcelo M Sales, Erica C C C Rosa, Thiago S Rosa, John E Lewis, Rosângela V Andrade, Herbert G Simões
Leukocyte telomere length (LTL), a biological marker of aging that is associated with age-related diseases, is longer in master endurance runners (ER) than age-matched controls, but the underlying mechanisms are poorly investigated. The LTL, nitric oxide (NO), and redox balance of ER master runners were analyzed and compared to untrained middle-aged and young adults. We hypothesized that NO and redox balance at baseline would be related to longer LTL in ER athletes. Participants (n = 38) were long-term ER runners (n = 10; 51...
November 24, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/30474505/telomere-homeostasis-and-senescence-markers-are-differently-expressed-in-placentas-from-pregnancies-with-early-versus-late-onset-preeclampsia
#14
Sivan Farladansky-Gershnabel, Hilah Gal, Debora Kidron, Valery Krizhanovsky, Aliza Amiel, Rivka Sukenik-Halevy, Tal Biron-Shental
BACKGROUND: Early-onset preeclampsia (EOPE; <34 weeks' gestation) usually has more severe morbidity for the mother and fetus compared to late-onset preeclampsia (LOPE). Telomere homeostasis is disrupted in preeclampsia (PE) and senescence markers are increased. The pathophysiologic differences between early and LOPE are not fully unraveled yet. METHODS: We studied placental biopsies from 7 pregnancies with EOPE, 6 pregnancies with LOPE, and 13 healthy gestational age-matched controls...
November 25, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/30474255/telomere-elongation-through-htert-immortalisation-leads-to-chromosome-repositioning-in-control-cells-and-genomic-instability-in-hutchinson-gilford-progeria-syndrome-fibroblasts-expressing-a-novel-sun1-isoform
#15
Mehmet U Bikkul, Richard G A Faragher, Gemma Worthington, Peter Meinke, Alastair R W Kerr, Aakila Sammy, Kumars Riyahi, Daniel Horton, Eric C Schirmer, Michael Hubank, Ian R Kill, Rhona M Anderson, Predrag Slijepcevic, Evgeny Makarov, Joanna M Bridger
Immortalising primary cells with hTERT has been common practice to enable primary cells to be of extended use in the laboratory since they avoid replicative senescence. Studying exogenously expressed hTERT in cells also affords scientists models of early carcinogenesis and telomere behaviour. Control and the premature ageing disease - Hutchinson-Gilford Progeria Syndrome primary dermal fibroblasts, with and without the classical G608G mutation have been immortalised with exogenous hTERT. However, hTERT immortalisation surprisingly elicits genome reorganisation, in disease cells but also in the normal control cells, such that whole chromosome territories normally located at the nuclear periphery in proliferating fibroblasts become mis-localised in the nuclear interior...
November 26, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/30474160/cognitive-performance-in-survivors-of-breast-cancer-and-markers-of-biological-aging
#16
Judith E Carroll, Kathleen Van Dyk, Julienne E Bower, Zorica Scuric, Laura Petersen, Robert Schiestl, Michael R Irwin, Patricia A Ganz
BACKGROUND: Biological aging pathways accelerated by cancer treatments may be a mechanism for cognitive impairment in cancer survivors. The goal of the current study was to examine whether indicators of biological aging, namely elevated levels of DNA damage, reduced telomerase enzymatic activity, and shorter peripheral blood mononuclear cell (PBMC) telomere length (TL) would be related to cognitive function in a cohort of survivors of breast cancer. METHODS: The authors evaluated a cross-sectional sample of 94 women aged 36 to 69 years who were treated for early-stage breast cancer 3 to 6 years previously...
November 26, 2018: Cancer
https://www.readbyqxmd.com/read/30472697/cell-cycle-dependent-and-independent-telomere-shortening-accompanies-murine-brain-aging
#17
Quratul Ain, Christian Schmeer, Diane Penndorf, Mike Fischer, Tzvetanka Bondeva, Martin Förster, Ronny Haenold, Otto W Witte, Alexandra Kretz
Replication-based telomere shortening during lifetime is species- and tissue-specific, however, its impact on healthy aging is unclear. In particular, the contribution of telomere truncation to the aging process of the CNS, where replicative senescence alone fails to explain organ aging due to low to absent mitotic activity of intrinsic populations, is undefined. Here, we assessed changes in relative telomere length in non-replicative and replicative neural brain populations and telomerase activity as a function of aging in C57BL/6 mice...
November 20, 2018: Aging
https://www.readbyqxmd.com/read/30469358/interactions-between-spermine-derivatized-tentacle-porphyrins-and-the-human-telomeric-dna-g-quadruplex
#18
Navin C Sabharwal, Jessica Chen, Joo Hyun June Lee, Chiara M A Gangemi, Alessandro D'Urso, Liliya A Yatsunyk
G-rich DNA sequences have the potential to fold into non-canonical G-Quadruplex (GQ) structures implicated in aging and human diseases, notably cancers. Because stabilization of GQs at telomeres and oncogene promoters may prevent cancer, there is an interest in developing small molecules that selectively target GQs. Herein, we investigate the interactions of meso -tetrakis-(4-carboxysperminephenyl)porphyrin (TCPPSpm4) and its Zn(II) derivative (ZnTCPPSpm4) with human telomeric DNA (Tel22) via UV-Vis, circular dichroism (CD), and fluorescence spectroscopies, resonance light scattering (RLS), and fluorescence resonance energy transfer (FRET) assays...
November 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30467655/developmental-history-and-stress-responsiveness-are-related-to-response-inhibition-but-not-judgement-bias-in-a-cohort-of-european-starlings-sturnus-vulgaris
#19
Annie Gott, Clare Andrews, Tom Bedford, Daniel Nettle, Melissa Bateson
Judgement bias tasks are designed to provide markers of affective states. A recent study of European starlings (Sturnus vulgaris) demonstrated modest familial effects on judgement bias performance, and found that adverse early experience and developmental telomere attrition (an integrative marker of biological age) both affected judgement bias. Other research has shown that corticosterone levels affect judgement bias. Here, we investigated judgement bias using a modified Go/No Go task in a new cohort of starlings (n = 31) hand-reared under different early-life conditions...
November 23, 2018: Animal Cognition
https://www.readbyqxmd.com/read/30466069/telomere-shortening-in-alcohol-dependence-roles-of-alcohol-and-acetaldehyde
#20
Naruhisa Yamaki, Sachio Matsushita, Sachiko Hara, Akira Yokoyama, Akitoyo Hishimoto, Susumu Higuchi
Heavy drinking leads to premature aging and precipitates the onset of age-related diseases. Acetaldehyde (AcH), a toxic metabolite of ethanol, has been implicated in various types of cancer. However, whether alcohol accelerates biological aging at a cellular level is controversial and the mechanism involved is unclear. We addressed these questions by measuring telomere length (TL) in peripheral blood leukocytes of Japanese patients with alcohol dependence (AD) and examined the association between TL, genetic variants of alcohol dehydrogenase (ADH)1B and aldehyde dehydrogenase (ALDH)2, and other clinical characteristics...
November 8, 2018: Journal of Psychiatric Research
keyword
keyword
161370
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"