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Telomere AND aging

Kim E Innes, Terry Kit Selfe, Kathleen Brundage, Caitlin Montgomery, Sijin Wen, Sahiti Kandati, Hannah Bowles, Dharma Singh Khalsa, Zenzi Huysmans
BACKGROUND: Telomere length (TL), telomerase activity (TA), and plasma amyloid-β (Aβ) levels have emerged as possible predictors of cognitive decline and dementia. OBJECTIVE: To assess the: 1) effects of two 12-week relaxation programs on TL, TA, and Aβ levels in adults with subjective cognitive decline; and 2) relationship of biomarker changes to those in cognitive function, psychosocial status, and quality of life (QOL). METHODS: Participants were randomized to a 12-week Kirtan Kriya meditation (KK) or music listening (ML) program and asked to practice 12 minutes/day...
October 11, 2018: Journal of Alzheimer's Disease: JAD
Lurdes Planas-Cerezales, Elena G Arias-Salgado, Ivette Buendia-Roldán, Ana Montes-Worboys, Cristina E López, Vanesa Vicens Zygmunt, Patricio L Hernaiz, Roger L Sanuy, Virginia Leiro-Fernandez, Eva B Vilarnau, Ernest S Llinás, Jordi D Sargatal, Rosario P Abellón, Moisés Selman, Maria Molina-Molina
BACKGROUND AND OBJECTIVE: The abnormal shortening of telomeres is a mechanism linking ageing to idiopathic pulmonary fibrosis (IPF) that could be useful in the clinical setting. The objective of this study was to identify the IPF patients with higher risk for telomere shortening and to investigate the outcome implications. METHODS: Consecutive Spanish patients were included at diagnosis and followed up for 3 years. DNA blood samples from a Mexican cohort were used to validate the results found in Spanish sporadic IPF...
October 15, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
Raheleh Farahzadi, Ezzatollah Fathi, Seyed Alireza Mesbah-Namin, Nosratollah Zarghami
The identification of factors that reduce the senescent tendency of the mesenchymal stem cells (MSCs) upon expansion has great potential for cellular therapies in regenerative medicine. Previous studies have shown the aging protective effect of L-carnitine (LC). On the other hand, reduction in proliferation potential and age-dependent decline in number and functions of MSCs were accompanied by telomere shortening, reduction in telomerase activity and epigenetic changes. The aim of this study was to evaluate the effects of LC on aging of MSCs through telomerase activity assessment and the investigation of methylation status of the hTERT gene promoter...
October 2018: Tissue & Cell
Hiroshi Moritake
Recently, the modern technique of comprehensive genomic analysis has identified both somatic mutations originating from tumor cells and germline mutations as causative genes of inherited familial leukemias among which Fanconi anemia and Li-Fraumeni syndrome are well known. Pathogenic germline mutations occur in various pathways, affecting DNA repair, ribosome biogenesis, telomere biology, hematopoietic transcription factors, tumor suppressors, neutrophil development, and other critical cellular processes. The clinical manifestations of germline mutations present a wide phenotypic spectrum of patients displaying congenital anomalies, early-onset myelodysplastic syndrome, or no medical problems until the developing leukemia...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Hidetoshi Tahara
Prevention and early detection of age-associated diseases are critical to achieve healthy longevity among the super-aged individuals. To this end, technology that can assess the risk of diseases before onset and that can detect diseases at an early stage for early treatment intervention is essential. Technology that measures telomere G-tail length can be used to examine the risk of age-associated diseases, while miRNAs may serve as a novel diagnostic marker for the early detection of diseases, such as cancer and dementia...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Luis Alejandro Arias-Sosa
In modern society, fertility problems and demand of treatment seem to be on the rise, which led to an increased interest in research regarding human reproduction. Among these efforts, the study of the molecular senescence process has gain notorious popularity as aging is one of the most important variables involved in reproductive capacity and since the comprehension of telomere dynamics has become an important and influential theme. This new knowledge regarding the reproductive aging process is expected to offer new tools to understand the acquisition, maintenance, and loss of fertility potential...
October 8, 2018: Reproductive Sciences
Joel Jimenez Villarreal, Blanca Murillo Ortiz, Sandra Martinez Garza, Diana Isabel Rivas Armendáriz, Víctor Daniel Boone Villa, Pilar Carranza Rosales, Nadia Denys Betancourt Martínez, Héctor Delgado Aguirre, Javier Morán Martínez
Differentiated cells telomere length is an indicator of senescence or lifespan; however, in peripheral blood leukocytes the relative shortening of the telomere has been considered as a biological marker of aging, and lengthening telomere as an associated risk to cancer. Individual's age, type of tissue, lifestyle, and environmental factors make telomere length variable. The presence of environmental carcinogens such as arsenic (As) influence as causal agents of these alterations, the main modes of action for As described are oxidative stress, reduction in DNA repair capacity, overexpression of genes, alteration of telomerase activity, and damage to telomeres...
October 6, 2018: Journal of Biochemical and Molecular Toxicology
Resham Lal Gurung, M Yiamunaa, Sylvia Liu, Jian-Jun Liu, Si Min Chan, Mei Chung Moh, Keven Ang, Wern Ee Tang, Chee Fang Sum, Tavintharan Subramaniam, Su Chi Lim
BACKGROUND: Obesity and shorter telomeres increase the risk for diabetes complications and mortality. However, the relationship of obesity and telomere length in diverse Asian population with type 2 diabetes (T2D) is not well understood. In this study, we examine the association of the baseline and changes in obesity indices, with telomere length in multi-ethnic Asian populations with T2D. METHODS: Leukocyte telomere length (LTL) was measured by qPCR assay in SMART2D cohort (n=1431 at baseline, n= 1039 after 3...
October 3, 2018: Journal of Diabetes
Maria Santa Rocca, Carlo Foresta, Alberto Ferlin
Telomeres are repeated DNA sequences whose main function is to preserve genome stability, protecting chromosomes ends from shortening caused by progressive loss during each cell replication or DNA damage. Telomere length regulation is normally achieved by telomerase enzyme, whose activity is progressively shut off during embryonic differentiation in somatic tissues, whereas it is maintained in germ cells, activated lymphocytes, and certain types of stem cell populations. The maintenance of telomerase activity for a longer time is necessary for germ cells to delay telomere erosion, avoiding thus chromosome segregation defects that could contribute to aneuploid or unbalanced gametes...
October 1, 2018: Biology of Reproduction
Maria Clara Bonaglia, Nehir Edibe Kurtas, Edoardo Errichiello, Sara Bertuzzo, Silvana Beri, Mana M Mehrjouy, Aldesia Provenzano, Debora Vergani, Vanna Pecile, Francesca Novara, Paolo Reho, Marilena Carmela Di Giacomo, Giancarlo Discepoli, Roberto Giorda, Micheala A Aldred, Cíntia Barros Santos-Rebouças, Andressa Pereira Goncalves, Diane N Abuelo, Sabrina Giglio, Ivana Ricca, Fabrizia Franchi, Philippos Patsalis, Carolina Sismani, María Angeles Morí, Julián Nevado, Niels Tommerup, Orsetta Zuffardi
We investigated 52 cases of de novo unbalanced translocations, consisting in a terminally deleted or inverted-duplicated deleted (inv-dup del) 46th chromosome to which the distal portion of another chromosome or its opposite end was transposed. Array CGH, whole-genome sequencing, qPCR, FISH, and trio genotyping were applied. A biparental origin of the deletion and duplication was detected in 6 cases, whereas in 46, both imbalances have the same parental origin. Moreover, the duplicated region was of maternal origin in more than half of the cases, with 25% of them showing two maternal and one paternal haplotype...
October 1, 2018: Human Genetics
Lisa Gallicchio, Shahinaz M Gadalla, John D Murphy, Naoko I Simonds
Background: It has been hypothesized that cancer treatments cause accelerated aging through a mechanism involving the shortening of telomeres. However, the effect of cancer treatments on telomere length is unclear. Methods: We systematically reviewed the epidemiological evidence evaluating the associations between cancer treatment and changes in telomere length. Searches were performed in PubMed for the period of January 1966 through November 2016 using the following search strategy: telomere AND (cancer OR tumor OR carcinoma OR neoplasm) AND (survivor OR patient)...
October 1, 2018: Journal of the National Cancer Institute
Wanlada Sawangarun, Masita Mandasari, Junko Aida, Kei-Ichi Morita, Kou Kayamori, Tohru Ikeda, Kei Sakamoto
Notch signaling functions in diverse developmental and homeostatic processes, including stem cell self-renewal and cell fate determination. Notch1-inactivating mutations are frequently detected in skin and oro-esophageal cancers, suggesting a role for Notch1 as a tumor suppressor. Here, we clarify the contribution of Notch1 deficiency to oro-esophageal tumorigenesis using a physiological experimental model. Tongue and esophageal tumors induced in mice by 4-nitroquinoline-1-oxide (4-NQO) showed pathophysiological similarities to human tumors, including decreased Notch1 expression in the basal cells...
September 25, 2018: Experimental Cell Research
Eli Puterman, Jordan Weiss, Jue Lin, Samantha Schilf, Aaron L Slusher, Kirsten L Johansen, Elissa S Epel
STUDY DESIGN: Family members caring for chronically ill relatives are typically sedentary, chronically stressed, and at high risk of disease. Observational reports suggest caregivers have accelerated cellular aging as indicated by shorter leukocyte telomere lengths. We performed a randomized controlled trial to examine the effect of aerobic exercise on changes in telomerase levels (primary outcome) and telomere lengths (secondary outcome) in inactive caregivers. METHODS: 68 female and male community dwelling dementia caregivers who reported high stress and physical inactivity were randomly assigned to a highly supervised aerobic exercise intervention vs...
August 2, 2018: Psychoneuroendocrinology
Clare L Fasching
Telomere length measurement is increasingly recognized as a clinical gauge for age-related disease risk. There are several methods for studying blood telomere length (BTL) as a clinical biomarker. The first is an observational study approach, which directly measures telomere lengths using either cross-sectional or longitudinal patient cohorts and compares them to a population of age- and sex-matched individuals. These direct traceable measurements can be considered reflective of an individual's current health or disease state...
September 28, 2018: Critical Reviews in Clinical Laboratory Sciences
Sarah Herwest, Carolin Albers, Maren Schmiester, Bastian Salewsky, Werner Hopfenmüller, Antje Meyer, Lars Bertram, Ilja Demuth
The polymorphism rs11552449 (c.181C > T, p.His61Tyr) in the hSNM1B/Apollo gene has been repeatedly shown to be associated with an increased risk for breast cancer. The aim of the current study was to investigate the association between rs11552449 and the degree of cellular sensitivity to mitomycin C (MMC) and ionizing radiation (IR). A total of 69 lymphoblastoid cell lines (LCLs) from generally healthy donors were tested for their sensitivity towards MMC and IR in growth inhibition experiments. LCLs heterozygous for rs11552449 were significantly more sensitive to MMC and IR than homozygous cells with the CC genotype (p < 0...
September 12, 2018: DNA Repair
Kaori Fujishiro, Belinda L Needham, Paul A Landsbergis, Teresa Seeman, Nancy Swords Jenny, Ana V Diez Roux
Telomere length (TL) is considered as a marker of cell senescence, but factors influencing the rate of TL attrition are not well understood. While one previous study reported the association of occupation and TL, many subsequent studies have failed to find the association. This may be due to heterogeneity within the samples and cross-sectional designs. This longitudinal study examines two occupational characteristics, occupational complexity and hazardous conditions, as predictors of TL attrition in gender- and race/ethnicity-stratified analysis...
2018: PloS One
Amedeo Lonardo, Simonetta Lugari, Fabio Nascimbeni
No abstract text is available yet for this article.
October 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Qi Wang, Yiqiang Zhan, Nancy L Pedersen, Fang Fang, Sara Hägg
Telomere attrition is associated with increased morbidity and mortality of various age-related diseases. Reports of association between telomere length (TL) and all-cause mortality remain inconsistent. In the present study, a meta-analysis was performed using published cohort studies and un-published data from the Swedish Twin Registry (STR). Twenty-five studies were included: four STR cohorts (12,083 individuals with 2517 deaths) and 21 published studies. In the STR studies, one standard deviation (SD) decrement of leukocyte TL corresponded to 13% increased all-cause mortality risk (95% confidence interval [CI]: 7%-19%); individuals in the shortest TL quarter had 44% higher hazard (95% CI: 27%-63%) than those in the longest quarter...
September 22, 2018: Ageing Research Reviews
Seyung S Chung, Pranabananda Dutta, David Austin, Piwen Wang, Adam Awad, Jaydutt V Vadgama
Colorectal cancer is one of the leading causes for mortalities worldwide. The most common cause of colorectal cancer mortality is hepatic metastasis. There has been a limited advancement in the targeted-therapies for metastatic colorectal cancer. Conventional chemotherapeutic agent 5-fluorouracil has been used for various cancer treatments including colorectal cancer. Development of drug resistance and severe toxicity are major hurdles for its use in clinical setting. Resveratrol is a natural polyphenolic compound which has protective effects against aging-related diseases...
August 31, 2018: Oncotarget
Yu-Chi Huang, Liang-Jen Wang, Ping-Tao Tseng, Chi-Fa Hung, Pao-Yen Lin
The purpose of the present meta-analysis was to compare leukocyte telomere length (LTL), a proposed marker for cell aging, between patients with bipolar disorder (BD) and healthy controls and explore potential moderators for the LTL difference. We searched for the major research databases up to May 2018 for studies that examined LTL in patients with BD and healthy controls. The effect sizes (ESs) of LTL differences from the included studies were pooled using a random-effects model. Furthermore, we adopted subgroup analysis to investigate whether mood status of BD patients or methods for measuring telomere length may influence such differences...
September 17, 2018: Psychiatry Research
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