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Telomere AND aging

Tahereh Setayesh, Armen Nersesyan, Miroslav Mišík, Franziska Ferk, Sabine Langie, Vanessa M Andrade, Alexander Haslberger, Siegfried Knasmüller
Health authorities are alarmed worldwide about the increase of obesity and overweight in the last decades which lead to adverse health effects including inflammation, cancer, accelerated aging and infertility. We evaluated the state of knowledge concerning the impact of elevated body mass on genomic instability. Results of investigations with humans (39 studies) in which DNA damage was monitored in lymphocytes and sperm cells, are conflicting and probably as a consequence of heterogeneous study designs and confounding factors (e...
July 2018: Mutation Research
Miguel A Muñoz-Lorente, Paula Martínez, Águeda Tejera, Kurt Whittemore, Ana Carolina Moisés-Silva, Fàtima Bosch, Maria A Blasco
Short and dysfunctional telomeres are sufficient to induce a persistent DNA damage response at chromosome ends, which leads to the induction of senescence and/or apoptosis and to various age-related conditions, including a group of diseases known as "telomere syndromes", which are provoked by extremely short telomeres owing to germline mutations in telomere genes. This opens the possibility of using telomerase activation as a potential therapeutic strategy to rescue short telomeres both in telomere syndromes and in age-related diseases, in this manner maintaining tissue homeostasis and ameliorating these diseases...
August 2018: PLoS Genetics
Stephanie J Wilson, Alex Woody, Avelina C Padin, Jue Lin, William B Malarkey, Janice K Kiecolt-Glaser
Background: Lonely people's heightened risks for chronic health conditions and early mortality may emerge in part through cellular aging. Lonelier people have more severe sympathetic responses to acute stress, increasing their risk for herpesvirus reactivation, a possible path to shorter telomeres. Parasympathetic function may modulate this risk. Purpose: The current study aimed to examine the associations among loneliness, herpesvirus reactivation, and telomere length, with parasympathetic activity as a moderator, in healthy middle-aged and older adults...
August 13, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Maryam Abdollahi, MingYang Meah Gao, David G Munoz
Dyskeratosis congenita (DKC) is a rare, inherited disorder classically known by the triad of nail dystrophy, mucosal leukoplakia, and lacy reticulated skin hyperpigmentation. Bone marrow failure is a prominent feature and accounts for most deaths in these patients. Genetic mutations resulting in shortened telomeres have been shown to cause DKC, which is the basis for categorizing it as a "premature aging syndrome". Different modes of inheritance have been identified with X-linked recessive as the most common...
August 14, 2018: Clinical Neuropathology
Zhu Lin, Hongmei Gao, Bing Wang, Yongqiang Wang
Background: Telomere is regarded as the fundamental aspect of cellular aging and copper is recognized as one of the most essential trace elements. The role of dietary copper intake in telomere length maintenance is seldom examined. This study aims to investigate if telomere length is to be associated with daily dietary copper intake. Methods: We used epidemiological data from a large national population-based health and nutrition survey. Dietary intake was assessed during the 24-h period before the interview date when blood sample was collected...
2018: Frontiers in Endocrinology
Cristiana L Miranda-Furtado, Heloise R Luchiari, Daiana C Chielli Pedroso, Gislaine S Kogure, Lisandra C Caetano, Bárbara A Santana, Viviane P Santana, Cristina L Benetti-Pinto, Fernando M Reis, Mariella A Maciel, Rui A Ferriani, Ester S Ramos, Rodrigo T Calado, Rosana M Dos Reis
OBJECTIVE: To analyze whether telomere length, X-chromosome inactivation (XCI), and androgen receptor (AR) GAG polymorphism are related to idiopathic premature ovarian insufficiency (POI). DESIGN: Case-control study. SETTING: University hospital. PATIENT(S): A total of 121 women, including 46 nonsyndromic POI and 75 controls. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Age, weight, height, body mass index (BMI), systolic and diastolic arterial pressure, E2 , androstenedione, T, and C-reactive protein were assessed...
August 2018: Fertility and Sterility
Wenshan Fu, Zhuowang Chen, Yansen Bai, Xiulong Wu, Guyanan Li, Weilin Chen, Gege Wang, Suhan Wang, Xiaoliang Li, Meian He, Xiaomin Zhang, Tangchun Wu, Huan Guo
Telomere length (TL) is an index of cellular aging and can predict the incidences of many age-related diseases. Change of TL might be affected by environmental pollution and individual's genetic background. In this cohort study, we aimed to evaluate the associations between polycyclic aromatic hydrocarbons (PAHs) exposure and longitudinal TL shortening, and investigate whether genetic variations in TERT-CLPTM1L can modify these associations. We measured the baseline concentrations of twelve urinary PAH metabolites and genotyped six variants at TERT-CLPTM1L among 1243 coke-oven workers...
August 7, 2018: Environmental Pollution
Ken-Ichiro Tomita, Junko Aida, Naotaka Izumiyama-Shimomura, Ken-Ichi Nakamura, Naoshi Ishikawa, Yoko Matsuda, Tomio Arai, Toshiyuki Ishiwata, Toshio Kumasaka, Junko Takahashi-Fujigasaki, Naoki Hiraishi, Misaki Yamada, Mutsunori Fujiwara, Kaiyo Takubo
AIM: The telomere is a structure present at the ends of chromosomes, and is known to shorten with aging and successive rounds of cell division. However, very little is known about telomere attrition in post-mitotic cells, such as neurons. METHODS: Using our originally developed quantitative fluorescence in situ hybridization method, we analyzed age-dependent alterations of telomere length in three types of cells in the human cerebrum: neurons and glial cells in both the gray and white matter...
August 10, 2018: Geriatrics & Gerontology International
Tim De Meyer, Tim Nawrot, Sofie Bekaert, Marc L De Buyzere, Ernst R Rietzschel, Vicente Andrés
Telomeres shorten with age, the major risk factor for atherosclerotic cardiovascular disease (aCVD). The observation of shorter telomeres in aCVD patients thus suggested that critical telomere shortening may contribute to premature biological aging and aCVD. Therefore, telomere length often is suggested as a causal aCVD risk factor, a proposal supported by recent Mendelian randomization studies; however, epidemiological research has shown disappointingly low effect sizes. It therefore remains uncertain whether telomere shortening is a cause of aCVD or merely a consequence...
August 14, 2018: Journal of the American College of Cardiology
Maryam Majidinia, Russel J Reiter, Seyed Kazem Shakouri, Bahman Yousefi
Biological ageing is generally accompanied by a gradual loss of cellular functions and physiological integrity of organ systems, the consequential enhancement of vulnerability, senescence and finally death. Mechanisms which underlie ageing are primarily attributed to an array of diverse but related factors including free radical-induced damage, dysfunction of mitochondria, disruption of circadian rhythms, inflammaging, genomic instability, telomere attrition, loss of proteostasis, deregulated sensing of nutrients, epigenetic alterations, altered intercellular communication, and decreased capacity for tissue repair...
August 6, 2018: Ageing Research Reviews
Iulia Popescu, Hannah Mannem, Spencer A Winters, Aki Hoji, Fernanda Silveira, Emily McNally, Matthew R Pipeling, Elizabeth A Lendermon, Matthew R Morrell, Joseph M Pilewski, Vidya Sagar Hanumanthu, Yingze Zhang, Swati Gulati, Pali D Shah, Carlo J Iasella, Christopher R Ensor, Mary Armanios, John F McDyer
RATIONALE: CMV-related morbidities remain one of the most common complications after lung transplantation and have been linked to allograft dysfunction, but the factors that predict high-risk for CMV complications and effective immunity are incompletely understood. OBJECTIVES: To determine if short telomeres in idiopathic pulmonary fibrosis (IPF) lung transplant recipients (LTRs) predict the risk for CMV-specific T-cell immunity and viral control. METHODS: We studied IPF-LTRs (n=42) and age-matched non-IPF-LTRs (n=42) and assessed CMV outcomes...
August 8, 2018: American Journal of Respiratory and Critical Care Medicine
Wilfried Renner, Sabine Krenn-Pilko, Hans-Jürgen Gruber, Markus Herrmann, Tanja Langsenlehner
PURPOSE: Telomeres are essential for the maintenance of chromosomal integrity and telomere length has been associated with cancer risk and development. Aim of the present study was to analyze the prognostic value of leukocyte relative telomere (RTL) length in long-term prostate cancer (PCa) mortality. METHODS: Blood samples of PCa patients were obtained before initiation of radiotherapy. RTL of peripheral blood leukocytes was determined by a quantitative polymerase chain reaction method in 533 patients with PCa...
August 6, 2018: Prostate Cancer and Prostatic Diseases
Rachel Bayley, Daniel Blakemore, Laila Cancian, Stephanie Dumon, Giacomo Volpe, Carl Ward, Ruba Almaghrabi, Jidnyasa Gujar, Natasha Reeve, Manoj Raghavan, Martin R Higgs, Grant S Stewart, Eva Petermann, Paloma Garcia
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by blood cytopenias that occur as a result of somatic mutations in hematopoietic stem cells (HSC). MDS leads to ineffective haematopoiesis, and as many as 30% of patients progress to acute myeloid leukaemia (AML). The mechanisms by which mutations accumulate in HSC during aging remain poorly understood. Here we identify a novel role for MYBL2 in DNA double-strand break (DSB) repair in HSC. In MDS patients, low MYBL2 levels associated with and preceded transcriptional deregulation of DNA repair genes...
August 6, 2018: Cancer Research
David P Steensma
Clonal hematopoiesis (CH)-an expansion of blood cells derived from a single hematopoietic stem cell-is a defining feature of hematologic cancers, but recently CH was also found to be a frequent consequence of aging. When aging-associated CH results from acquisition of a somatic mutation in a driver gene associated with leukemia, and this mutation is present at a variant allele frequency of at least 0.02 (2%) yet the patient does not meet World Health Organization diagnostic criteria for a hematologic neoplasm, this state is termed clonal hematopoiesis of indeterminate potential (CHIP)...
August 2018: Mayo Clinic Proceedings
Christine M Friedenreich, Qinggang Wang, Nicholas S Ting, Darren R Brenner, Shannon M Conroy, John B McIntyre, Alexis Mickle, Kerry S Courneya, Tara Beattie
BACKGROUND: Short telomeres may indicate a higher risk of cancer and other chronic diseases. Some observational studies show positive associations between leukocyte telomere length (LTL) and physical activity levels. We hypothesized, therefore, that exercise may be one strategy for slowing telomere attrition. METHODS: We conducted an ancillary analysis of blood from a year-long, two-centred, two-armed (1:1) randomized controlled trial of aerobic exercise versus usual inactivity...
July 31, 2018: Cancer Epidemiology
Joshua N Farr, Maria Almeida
Aging research has undergone unprecedented advances at an accelerating rate in recent years, leading to excitement in the field as well as opportunities for imagination and innovation. Novel insights indicate that, rather than resulting from a pre-programmed series of events, the aging process is predominantly driven by fundamental non-adaptive mechanisms that are interconnected, linked, and overlap. To varying degrees, these mechanisms also manifest with aging in bone where they cause skeletal fragility. Because these mechanisms of aging can be manipulated, it might be possible to slow, delay, or alleviate multiple age-related diseases and their complications by targeting conserved genetic signaling pathways, controlled functional networks, and basic biochemical processes...
August 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Maria Molina-Molina, Raphael Borie
PURPOSE OF REVIEW: Telomere attrition has been proposed as one of the aging hallmarks in pulmonary fibrosis. Telomere shortening and telomerase gene mutations have been widely evaluated in recent years. Reduced telomere length may be identified in a quarter of patients with sporadic idiopathic pulmonary fibrosis (IPF) and half of those cases with family aggregation. However, telomere studies have not transferred from the research field to the clinic. This review is focused on our current understanding of the pathogenic implication of telomere dysfunction in lung fibrosis and its relevance in the clinical setting...
September 2018: Current Opinion in Pulmonary Medicine
Naoki Hiraishi, Masanori Terai, Mutsunori Fujiwara, Junko Aida, Naotaka Izumiyama-Shimomura, Naoshi Ishikawa, Ken-Ichiro Tomita, Yoko Matsuda, Tomio Arai, Kaiyo Takubo, Toshiyuki Ishiwata
In order to investigate the population dynamics of telomere status, we measured the telomere lengths of glandular cells in the adenohypophysis (AH) and pituicytes, a type of glial cell, in the neurohypophysis (NH) of 128 autopsied humans (65 men, 63 women, 0 and 102 years) using our original quantitative fluorescence in situ hybridization (Q-FISH) method. Telomeres in the AH shortened with aging in both men and women, but those of pituicytes did not. Pituicyte telomeres were significantly longer in women than in men...
August 2018: Tissue & Cell
Alexander Vaiserman, Alexander Koliada, Oleh Lushchak
There is accumulating evidence that aging phenotype and longevity may be developmentally programmed. Main mechanisms linking developmental conditions to later-life health outcomes include persistent changes in epigenetic regulation, (re)programming of major endocrine axes such as growth hormone/insulin-like growth factor axis and hypothalamic-pituitary-adrenal axis and also early-life immune maturation. Recently, evidence has also been generated on the role of telomere biology in developmental programming of aging trajectory...
July 27, 2018: Ageing Research Reviews
Todd Lucas, Jacqueline Woerner, Jennifer Pierce, Douglas A Granger, Jue Lin, Elissa S Epel, Shervin Assari, Mark A Lumley
OBJECTIVE: Believing in justice can protect health. Among marginalized racial minorities however, both endorsing and rejecting beliefs about justice might be critical. The current research examined links between African Americans' beliefs about justice for self and for others and telomere length (TL)-an indicator of biological aging that is increasingly implicated in racial health disparities, with shorter telomeres indicating poorer health. METHOD: Healthy African Americans (N = 118; 30% male; M age = 31...
July 30, 2018: Cultural Diversity & Ethnic Minority Psychology
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