Yixin Zhao, Xiaopei Li, Ni Sun, Yan Mao, Teng Ma, Xiangping Liu, Tao Cheng, Xiangyu Shao, Haifeng Zhang, Xianggang Huang, Junsheng Li, Ningping Huang, Haibo Wang
Abdominal wall defects are common clinical diseases, and mesh repair is the standard treatment method. The most commonly used polypropylene (PP) mesh in clinical practice has the advantages of good mechanical properties, stable performance, and effective tissue integration effect. However, direct contact between abdominal viscera and PP mesh can lead to severe abdominal adhesions. To prevent this, the development of a hydrogel-PP composite mesh with anti-adhesive properties may be an effective measure. Herein, biofunctional hydrogel loaded with rosmarinic acid is developed by modifying chitosan and Pluronic F127, which possesses suitable physical and chemical properties and commendable in vitro biocompatibility...
March 3, 2024: Advanced Healthcare Materials