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LASP1

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https://www.readbyqxmd.com/read/30372896/lasp1-promotes-glioma-cell-proliferation-and-migration-and-is-negatively-regulated-by-mir-377-3p
#1
Ying Liu, Yang Gao, Deheng Li, Luyun He, Lao Iw, Bin Hao, Xin Chen, Yiqun Cao
Glioma is one of the most aggressive and lethal human cancers with a low cure rate. LASP1 plays an oncogenic role in multiple human cancers; however, its role in glioma remains largely unknown. Here, we found that LASP1 was highly expressed in glioma tissue samples. Functionally, knockdown of LASP1 significantly suppressed glioma cell proliferation and migration in vitro and tumorigenicity in vivo. These effects were found to be mechanistically associated with suppression of AKT activity. Furthermore, we identified LASP1 as a direct target of miR-377-3p...
December 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30338803/microrna-203-inhibits-invasion-and-induces-apoptosis-of-laryngeal-cancer-cells-via-targeting-lasp1
#2
J Tan, Y-Y Jing, L Han, H-W Zheng, J-X Shen, L-H Zhang, L-S Yu
OBJECTIVE: To explore the role of microRNA-203 in laryngeal cancer and its underlying mechanism in regulating cell invasion and apoptosis. PATIENTS AND METHODS: MicroRNA-203 expression in laryngeal cancer tissues and paracancerous tissues was detected by quantitative real time-polymerase chain reaction (qRT-PCR). The regulatory effects of microRNA-203 on the invasion and apoptosis of laryngeal cancer cells were detected by transwell assay and flow cytometry, respectively...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30326930/long-noncoding-rna-afap1-as1-acts-as-a-competing-endogenous-rna-of-mir-423-5p-to-facilitate-nasopharyngeal-carcinoma-metastasis-through-regulating-the-rho-rac-pathway
#3
Yu Lian, Fang Xiong, Liting Yang, Hao Bo, Zhaojian Gong, Yumin Wang, Fang Wei, Yanyan Tang, Xiayu Li, Qianjin Liao, Hui Wang, Ming Zhou, Bo Xiang, Xu Wu, Yong Li, Xiaoling Li, Xiang Chen, Guiyuan Li, Can Guo, Zhaoyang Zeng, Wei Xiong
BACKGROUND: Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), a long noncoding RNA, is significantly highly expressed and associated with metastasis and poor prognosis in many cancers, including nasopharyngeal carcinoma (NPC). In this study, we aim to identify the role of AFAP1-AS1 acting as an oncogenic lncRNA to promote NPC metastasis. METHODS: The role of AFAP1-AS1, miR-423-5p, and FOSL2 in NPC metastasis was investigated in vitro and in vivo. Bioinformatics analysis and luciferase activity assays were used to identify the interaction between AFAP1-AS1, miR-423-5p, and FOSL2...
October 16, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30298118/new-frontiers-for-the-cytoskeletal-protein-lasp1
#4
REVIEW
Elke Butt, Dayanidhi Raman
In the recent two decades, LIM and SH3 protein 1 (LASP1) has been developed from a simple actin-binding structural protein to a tumor biomarker and subsequently to a complex, nuclear transcriptional regulator. Starting with a brief historical perspective, this review will mainly compare and contrast LASP1 and LASP2 from the angle of the newest data and importantly, examine their role in transcriptional regulation. We will summarize the current knowledge through pictorial models and tables including the roles of different microRNAs in the differential regulation of LASP1 levels and patient outcome rather than specify in detail all tumor entities...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30140627/role-of-microrna-21-in-uveal-melanoma-cell-invasion-and-metastasis-by-regulating-p53-and-its-downstream-protein
#5
Ying-Chih Wang, Xuan Yang, Wen-Bin Wei, Xiao-Lin Xu
AIM: To reveal the insight mechanism of liver metastasis in uveal melanoma, we investigated cell functions of microRNA-21 in three different uveal melanoma cell lines and analyze the relationship of target gene p53 and its downstream targets. METHODS: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect microRNA-21 expression in normal uveal tissue and uveal melanoma cell lines. Lenti-virus expression system was used to construct OCM-1, MuM-2B and M619 cell line with stable overexpression and inhibition of microRNA-21...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29980193/lim-and-sh3-protein-1-regulates-cell-growth-and-chemosensitivity-of-human-glioblastoma-via-the-pi3k-akt-pathway
#6
Chuanhong Zhong, Yitian Chen, Bei Tao, Lilei Peng, Tangming Peng, Xiaobo Yang, Xiangguo Xia, Ligang Chen
BACKGROUND: LIM and SH3 protein 1 (LASP1) is upregulated in several types of human cancer and implicated in cancer progression. However, the expression and intrinsic function of LASP1 in glioblastoma (GBM) remains unclear. METHOD: Oncomine and The Cancer Genome Atlas (TCGA) database was analyzed for the expression and clinical significance of LASP1 in GBM. LASP1 mRNA and protein level were measured by qRT-PCR and western blotting. The effect of LASP1 on GBM proliferation was examined by MTT assay and colony formation assay, the effect of LASP1 on sensitivity of Temozolomide was measured by flow cytometry and subcutaneous tumor model...
July 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29531214/lasp1-promotes-nasopharyngeal-carcinoma-progression-through-negatively-regulation-of-the-tumor-suppressor-pten
#7
Qingzu Gao, Lihua Tang, Ling Wu, Kaitao Li, Hui Wang, Weidong Li, Juan Wu, Mingyi Li, Shuang Wang, Liang Zhao
LIM and SH3 protein 1 (LASP1) enhances tumor growth and metastasis in various cancers, but its role in nasopharyngeal carcinoma (NPC) remains unclear. Herein, we investigated the role of LASP1 in NPC and explored the underlying mechanisms in NPC. Clinically, overexpression of LASP1 is associated with tumor metastasis and poor prognosis of NPC patients. Gain-of-function and loss-of-function assays showed that LASP1 promoted NPC cell proliferation, metastasis, and invasion in vitro and in vivo. Mechanistically, we observed clear co-localization between LASP1 and PTEN in NPC cells...
March 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29473505/lasp1-in-tumor-and-tumor-microenvironment
#8
Z Hu, X Wang, Y Cui, C Li, S Wang
The growing evidence shows that LIM and SH3 Domain Protein 1 (LASP1) is a multi-functional protein that plays important role in forming cytoskeleton and prognostic marker in different cancers. LASP1 expression is correlated with the grade, size, and the metastasis of tumor in clinical samples. And the upregulation of LASP1 facilitates tumor cells proliferation, migration, and invasion perhaps through the interaction with cytoskeleton and increased nuclear translocation. The underlying mechanism of LASP1 on tumor is still in the initial stage; therefore, the signaling pathways in various tumors are specifically summarized to deepen the biological understanding of LASP1...
2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29226323/cops5-and-lasp1-synergistically-interact-to-downregulate-14-3-3%C3%AF-expression-and-promote-colorectal-cancer-progression-via-activating-pi3k-akt-pathway
#9
Rui Zhou, Ziyun Shao, Jian Liu, Wanqi Zhan, Qingzu Gao, Zhihua Pan, Ling Wu, Lijun Xu, Yanqing Ding, Liang Zhao
Overexpression of LIM and SH3 protein 1 (LASP1) is required for colorectal cancer (CRC) development and progression. Here, C-Jun activation domain-binding protein-1 (Jab1), also known as COP9 signalosome subunit 5 (COPS5), was verified as a new LASP1-interacting protein through yeast two-hybrid assay. The role of COPS5 in LASP1-mediated CRC progression remains unknown. GST pull-down assay indicated that the SH3 domain of LASP1 could directly bind to MPN domain of COPS5. In vitro gain- and loss-of-function analyses revealed the stimulatory role of COPS5 on CRC cell proliferation, migration and invasion...
May 1, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29221174/methylation-induced-downregulation-and-tumor-suppressive-role-of-microrna-29b-in-gastric-cancer-through-targeting-lasp1
#10
Hui Li, Guoqing Liu, Ke Pan, Xiongying Miao, Yong Xie
MicroRNAs (miRs) have been demonstrated to play promoting or tumor suppressive roles in various human cancers, but the regulatory mechanism of miR-29b underlying gastric cancer development and progression still remains largely unclear. In the present study, we found that miR-29b was significantly downregulated in gastric cancer tissues and cell lines. Low expression of miR-29b was significantly associated with DNA methylation, and treatment with DNA methyltransferase inhibitor 5-Aza-20-deoxycytidine upregulated miR-29b in gastric cancer cells...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207145/microrna-133a-acts-as-a-tumour-suppressor-in-breast-cancer-through-targeting-lasp1
#11
Yanmin Sui, Xiaolei Zhang, Honglan Yang, Wei Wei, Minglin Wang
Many microRNAs (miRs) have been demonstrated to play promoting or tumor suppressive roles in human cancers including breast cancer. However, the molecular mechanism of miR-133a underlying the malignant progression of breast cancer still remains obscure. In the present study we observed that the expression of miR-133a was significantly downregulated in breast cancer tissues and cell lines, when compared with adjacent non-tumor tissues and normal breast cell line, respectively. Reduced miR-133a levels were significantly associated with advanced clinical stage, lymph node metastasis, as well as shorter survival time of patients with breast cancer...
February 2018: Oncology Reports
https://www.readbyqxmd.com/read/29042998/microrna-206-inhibits-the-viability-and-migration-of-medulloblastoma-cells-by-targeting-lim-and-sh3-protein-1
#12
Xuexia Pan, Zhimin Wang, Bin Wan, Zhenwen Zheng
MicroRNA (miR)-206 has been found to be deregulated in various types of human cancer, including medulloblastoma. However, the regulatory mechanism of miR-206 in medulloblastoma growth and metastasis remains largely unclear. In the present study, reverse transcription-quantitative polymerase chain reaction data indicated that miR-206 was significantly downregulated in medulloblastoma tissues compared with adjacent non-tumor tissues (P<0.01). Furthermore, low expression of miR-206 was significantly associated with seeding at presentation and anaplastic histology (P<0...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28982387/mir-203a-3p-suppresses-cell-proliferation-and-metastasis-through-inhibiting-lasp1-in-nasopharyngeal-carcinoma
#13
Ning Jiang, Xuesong Jiang, Zhenzhang Chen, Xue Song, Lirong Wu, Dan Zong, Dan Song, Li Yin, Dejun Wang, Cheng Chen, Xiuhua Bian, Xia He
BACKGROUND: miR-203a-3p was reported as a tumor suppressor and disregulated in many malignancies including nasopharyngeal carcinoma (NPC). However, its function in tumor growth and metastasis in NPC has rarely been reported. METHODS: The expression level of miR-203a-3p in human NPC tissues and cell lines was detected via real-time PCR (RT-PCR). Cell proliferation, migration and invasion were assessed in vitro by MTT, colony formation and transwell assay, respectively...
October 5, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28713953/microrna-326-inhibits-cell-proliferation-and-invasion-activating-apoptosis-in-hepatocellular-carcinoma-by-directly-targeting-lim-and-sh3-protein-1
#14
Shiping Hu, Yun Ran, Wenlin Chen, Yuncheng Zhang, Yongjian Xu
Hepatocellular carcinoma (HCC) is the fifth-most common cancer and third leading cause of cancer-related deaths worldwide. Increasing evidence indicates that dysregulation of microRNAs is often observed in HCC, and has been extensively investigated in terms of cancer formation, progression, diagnosis, therapy, and prognosis. Recently, microRNA-326 (miR-326) has been demonstrated to play important roles in multiple types of human cancer. However, the expression pattern, clinical significance, roles and regulatory mechanisms of miR-326 in HCC have yet to be elucidated...
September 2017: Oncology Reports
https://www.readbyqxmd.com/read/28667800/lasp2-enhances-tumor-invasion-via-facilitating-phosphorylation-of-fak-and-predicts-poor-overall-survival-of-non-small-cell-lung-cancer-patients
#15
Xiupeng Zhang, Lin Cai, Haijing Zhou, Yang Liu, Chuifeng Fan, Liang Wang, Ailin Li, Yuan Miao, Qingchang Li, Xueshan Qiu, Enhua Wang
Lasp2, as well as Lasp1, is a member of the LIM-protein subfamily of the nebulin group characterized by the combined presence of LIM and SH3 domains. Lasp1 and Lasp2 are highly conserved in their LIM, nebulin-like, and SH3 domains but differ significantly at their linker regions. Lasp1 had been described as an oncogenic protein that was highly expressed in diverse cancer types and facilitated tumor proliferation, invasion, and metastasis process. However, unlike Lasp1, little is known about the functions of Lasp2...
December 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28621232/paving-the-path-for-invasion-the-polyedric-role-of-lasp1-in-cancer
#16
REVIEW
Vitalba Ruggieri, Francesca Agriesti, Tiziana Tataranni, Roberto Perris, Domenica Mangieri
Although usually referred to as a structural actin-binding protein, LIM and SH3 domain-containing protein may actually be dynamically involved in the control of a wide spectrum of cellular processes, by virtue of its interaction with several molecular partners. Alongside being ubiquitously expressed in physiological conditions, LIM and SH3 domain-containing protein is overexpressed in a growing number of human cancers, in which it may actively contribute to their aggressiveness by promoting cell proliferation and migration...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28445005/proteomic-based-investigations-on-the-mode-of-action-of-the-marine-anticancer-compound-rhizochalinin
#17
Sergey A Dyshlovoy, Katharina Otte, Simone Venz, Jessica Hauschild, Heike Junker, Tatyana N Makarieva, Stefan Balabanov, Winfried H Alsdorf, Ramin Madanchi, Friedemann Honecker, Carsten Bokemeyer, Valentin A Stonik, Gunhild von Amsberg
Rhizochalinin (Rhiz) is a novel marine natural sphingolipid-like compound, which shows promising in vitro and in vivo activity in human castration-resistant prostate cancer. In the present study, a global proteome screening approach was applied to investigate molecular targets and biological processes affected by Rhiz in castration-resistant prostate cancer. Bioinformatical analysis of the data predicted an antimigratory effect of Rhiz on cancer cells. Validation of proteins involved in the cancer-associated processes, including cell migration and invasion, revealed downregulation of specific isoforms of stathmin and LASP1, as well as upregulation of Grp75, keratin 81, and precursor IL-1β by Rhiz...
June 2017: Proteomics
https://www.readbyqxmd.com/read/28412444/hypoxia-inducible-microrna-218-inhibits-trophoblast-invasion-by-targeting-lasp1-implications-for-preeclampsia-development
#18
Min Fang, Hechun Du, Bing Han, Guiyu Xia, Xiaoliang Shi, Feng Zhang, Qiqin Fu, Tao Zhang
Preeclampsia (PE) is a major contributor to maternal morbidity and mortality. However, the molecular mechanisms underlying PE progression are not well characterized. Here, we investigated the role of miR-218 in PE development. The expression of miR-218 and its host genes SLIT2 and SLIT3 was up-regulated in preeclamptic placentae compared to normal placentae. miR-218 expression was induced by hypoxia and decreased after knockdown of HIF-1α in an extravillous trophoblast cell line (HTR-8/SVneo). Chromatin immunoprecipitation assays showed direct binding of HIF-1α to the promoters of SLIT2 and SLIT3...
June 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28404954/upregulation-of-the-long-non-coding-rna-pvt1-promotes-esophageal-squamous-cell-carcinoma-progression-by-acting-as-a-molecular-sponge-of-mir-203-and-lasp1
#19
Pin-Dong Li, Jian-Li Hu, Charlie Ma, Hong Ma, Jing Yao, Li-Li Chen, Jing Chen, Tian-Tian Cheng, Kun-Yu Yang, Gang Wu, Wen-Jie Zhang, Ru-Bo Cao
Long non-coding RNAs are a group of non-coding RNAs longer than 200 nucleotides and possess diverse functions and exhibit exquisite cell-specific and developmental dynamic expression patterns. The role of the long non-coding RNA PVT1 in esophageal squamous cell carcinoma remains unsolved. Here, we showed that PVT1 expression is significantly up-regulated in ESCC tumor samples compared with their normal counterparts. Knockdown of PVT1 suppressed tumor growth in vitro and in vivo. Further studies revealed that silence of PVT1 lead to up-regulation of miR-203, and vice versa...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28322315/quantitative-proteomic-analysis-on-activated-hepatic-stellate-cells-reversion-reveal-stat1-as-a-key-regulator-between-liver-fibrosis-and-recovery
#20
Hongyu Zhang, Fangyan Chen, Xu Fan, Cong Lin, Yunwei Hao, Handong Wei, Weiran Lin, Ying Jiang, Fuchu He
Understanding the changes of activated HSCs reversion is an essential step toward clarifying the potential roles of HSCs in the treatment of liver fibrosis. In this study, we chose adipocyte differentiation mixture to induce LX-2 cells for 2 days in vitro as reversion phase, comparing with normal cultured LX-2 cells as activation phase. Mass spectrometric-based SILAC technology was adopted to study differentially expressed proteome of LX-2 cells between reversion and activation. Compared with activated HSCs, 273 proteins showed significant differences in reverted HSCs...
March 21, 2017: Scientific Reports
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