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https://www.readbyqxmd.com/read/30098024/intranasal-lidocaine-for-acute-management-of-primary-headaches-a-systematic-review
#1
Renée Dagenais, Peter J Zed
Intranasal lidocaine has been studied and recommended as an alternative in the management of acute headache. The objective of this systematic review was to evaluate the efficacy and safety of intranasal lidocaine in the acute management of primary headaches. The MEDLINE (1946 to May 2018), EMBASE (1974 to May 2018), Cochrane Central Register of Controlled Trials (2008 to May 2018), Cumulative Index to Nursing and Allied Health Literature (CINAHL) (1982 to May 2018), and ClincialTrials. gov online databases were searched...
August 11, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/30091660/relationship-between-postoperative-volume-of-macroadenomas-and-clinical-outcome-after-endoscopic-trans-sphenoidal-resection
#2
Valeria Onofrj, Carina Vallejo, Paulo Puac, Carlos Zamora, Mauricio Castillo
Purpose Although symptoms are expected to improve after the resection of pituitary macroadenomas, tumor resection volume does not always correlate with the patient's symptoms. Our objectives were to assess the pre and postoperative volumes of pituitary macroadenomas before, immediately after surgery and at follow-up, and to explore possible associations and correlations among these changes and symptoms. Materials and methods We retrospectively reviewed the clinical records and the preoperative and postoperative magnetic resonance imaging studies at 24 hours and at 3, 6 and 9 months follow-up of 146 patients who underwent surgery for pituitary macroadenomas...
August 9, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/30091160/sleep-disorders-and-migraine-review-of-literature-and-potential-pathophysiology-mechanisms
#3
Angeliki Vgontzas, Jelena M Pavlović
Migraine shares a complex and poorly understood relationship with sleep. Patients consistently report poor sleep prior to migraine attacks and during them, identifying poor sleep as a migraine trigger. However, anecdotally, sleep is reported to serve a therapeutic role in terminating headache. Are the associations between migraine and sleep simply the result of various bidirectional relationships? A growing body of evidence suggests there may be a common underlying etiology as well. Our objective was to review studies of sleep and migraine from the last 2 decades utilizing validated subjective and objective measures of sleep and to explore potential mechanisms underlying this complex relationship by incorporating recent advances in neuroscience...
August 8, 2018: Headache
https://www.readbyqxmd.com/read/30088106/pacap38-and-pac-1-receptor-blockade-a-new-target-for-headache
#4
Eloisa Rubio-Beltrán, Edvige Correnti, Marie Deen, Katharina Kamm, Tim Kelderman, Laura Papetti, Simone Vigneri, Antoinette MaassenVanDenBrink, Lars Edvinsson
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent inducer of migraine-like attacks, but the mechanism behind this has not been fully elucidated.Migraine is a neurovascular disorder, recognized as the second most disabling disease. Nevertheless, the antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor are the only prophylactic treatment developed specifically for migraine...
August 7, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/30087947/osteoanabolic-agents-for-osteoporosis
#5
REVIEW
Andrea V Haas, Meryl S LeBoff
Medications for osteoporosis are classified as either antiresorptive or anabolic. Whereas antiresorptive agents prevent bone resorption, anabolic agents promote new bone formation. Anabolics should be considered in individuals with severe osteoporosis, failure of alternative osteoporosis agents, intolerability or contraindications to other osteoporosis agents, and glucocorticoid-induced osteoporosis. There are currently two approved anabolic therapies, teriparatide and abaloparatide, and a third anabolic agent, romozosumab, is under review by the US Food and Drug Administration...
August 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/30087808/a-novel-association-between-oxybutynin-use-and-bilateral-acute-angle-closure-glaucoma-a-case-report-and-literature-review
#6
Abdullah Haddad, Mais Arwani, Osama Sabbagh
We are reporting a case of a 62-year-old male presenting with headache and blurry vision. His condition resolved with cessation of the presumed offending medication and urgent bilateral laser peripheral iridotomies since he failed medical therapy. This case presents a novel association between oxybutynin and bilateral acute angle-closure glaucoma (AACG).
June 4, 2018: Curēus
https://www.readbyqxmd.com/read/30080523/spelunking-meckel-cave-a-31-year-old-with-diplopia-and-loss-of-taste-and-smell
#7
Rajat Suri, Bonnie Ronish, Zafia Anklesaria, Hawkin Woo
A 31-year-old woman presented to the ED with a loss of taste and smell of 2 months' duration and a frontal headache, bilateral facial numbness, photophobia, and horizontal diplopia that was worse with far vision of 2 weeks' duration. A review of systems revealed mild nausea and decreased appetite without weight loss. She denied any cardiopulmonary symptoms, specifically no cough or shortness of breath. Her medical history was notable for arthralgias. The patient was diagnosed with ankylosing spondylitis, for which she had been taking etanercept for several months...
August 2018: Chest
https://www.readbyqxmd.com/read/30079848/utilisation-of-medications-to-reduce-symptoms-in-children-with-postural-orthostatic-tachycardia-syndrome
#8
Jeffrey R Boris, Thomas Bernadzikowski
BACKGROUND: Postural orthostatic tachycardia syndrome encompasses multiple disabling symptoms that interfere with daily activities. Non-pharmacologic approaches can be insufficient and can require adjunctive medications to manage symptoms. Minimal data exist in the literature on medication outcomes in these patients. We reviewed our database for medication management outcomes.Materials and MethodsPatients aged 18 years and younger at initial diagnosis met the inclusion criteria. All prescribed patient medications were extracted from the electronic health record, excluding medications for unrelated symptoms or comorbid diseases...
August 6, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/30078503/chronic-pain-in-refugees-with-posttraumatic-stress-disorder-ptsd-a-systematic-review-on-patients-characteristics-and-specific-interventions
#9
REVIEW
C Rometsch-Ogioun El Sount, P Windthorst, J Denkinger, K Ziser, C Nikendei, D Kindermann, J Ringwald, V Renner, S Zipfel, F Junne
OBJECTIVE: Chronic pain in patients with posttraumatic stress disorder (PTSD) is a frequent symptom and a complicating factor in the treatment of patients. The study' purpose is to systematically review the scientific literature on patients' characteristics and the effects of specific interventions implemented for the treatment of chronic pain in traumatized refugees. METHOD: A systematic search of the current literature was conducted in PubMed and Web of Science, from 1996 to 2017...
July 30, 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/30077942/acute-hypertensive-crisis-and-severe-headache-after-concurrent-use-of-armodafinil-and-tranylcypromine-case-report-and-review-of-the-literature
#10
Connor J Kinslow, Steven D Shapiro, Michael F Grunebaum, Eliza C Miller
Concurrent use of modafinil or armodafinil with monoamine oxidase inhibitors (MAOIs) is contraindicated due to a theoretical risk of drug synergism and acute hypertensive episodes. However, few data are available to substantiate that risk, and several case studies have suggested that the combination is safe. To our knowledge, we present the first case of a patient treated concurrently with armodafinil and tranylcypromine. The patient developed an acute hypertensive crisis with severe headache, nausea, blurry vision, and neck stiffness...
July 31, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30077204/cardiovascular-and-other-health-benefits-of-sauna-bathing-a-review-of-the-evidence
#11
REVIEW
Jari A Laukkanen, Tanjaniina Laukkanen, Setor K Kunutsor
Sauna bathing, an activity that has been a tradition in Finland for thousands of years and mainly used for the purposes of pleasure and relaxation, is becoming increasingly popular in many other populations. Emerging evidence suggests that beyond its use for pleasure, sauna bathing may be linked to several health benefits, which include reduction in the risk of vascular diseases such as high blood pressure, cardiovascular disease, and neurocognitive diseases; nonvascular conditions such as pulmonary diseases; mortality; as well as amelioration of conditions such as arthritis, headache, and flu...
August 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/30074556/unusual-headache-disorders
#12
Amaal Jilani Starling
PURPOSE OF REVIEW: Unusual headache disorders are less commonly discussed and may be misdiagnosed. These headache disorders frequently have a benign natural history; however, without reassurance, therapeutic education, and treatment, they can negatively affect the health and function of patients. RECENT FINDINGS: This article reviews the clinical features, diagnosis, workup, and proposed treatments for several unusual headache disorders including primary cough headache, primary headache associated with sexual activity, primary exercise headache, cold-stimulus headache, primary stabbing headache, nummular headache, hypnic headache, and headache attributed to travel in space...
August 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/30074553/cluster-headache-and-other-trigeminal-autonomic-cephalalgias
#13
Mark Burish
PURPOSE OF REVIEW: This article covers the clinical features, differential diagnosis, and management of the trigeminal autonomic cephalalgias (TACs). The TACs are composed of five diseases: cluster headache, paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT), short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA), and hemicrania continua. RECENT FINDINGS: New classifications for the TACs have two important updates; chronic cluster headache is now defined as remission periods lasting less than 3 months (formerly less than 1 month), and hemicrania continua is now classified as a TAC (formerly classified as other primary headache)...
August 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/30074551/headache-in-pregnancy
#14
Matthew S Robbins
PURPOSE OF REVIEW: Headache disorders are extraordinarily common and disproportionately impact women of childbearing age. This article reviews the importance of proper diagnosis, natural history, and management of headache disorders in pregnant and postpartum women. RECENT FINDINGS: Red flags for secondary headache specifically among pregnant women include elevated blood pressure and lack of a previous headache history, as well as a prolonged duration of the headache attack in those with a prior history of migraine...
August 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/30074550/headaches-due-to-low-and-high-intracranial-pressure
#15
Deborah I Friedman
PURPOSE OF REVIEW: Headache disorders attributed to low and high intracranial pressure are commonly encountered in specialty headache practices and may occur more frequently than realized. While the headaches resulting from intracranial pressure disorders have what are conventionally thought of as defining characteristics, a substantial minority of patients do not manifest the "typical" features. Moreover, patients with intracranial pressure disorders may also have a preexisting primary headache disorder...
August 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/30074549/preventive-therapy-of-migraine
#16
Todd J Schwedt
PURPOSE OF REVIEW: This article reviews the preventive therapy of migraine, including indications, strategies for use, and available treatments. RECENT FINDINGS: Lifestyle modifications and migraine trigger avoidance are recommended as preventive measures for all individuals with migraine. The decision to recommend additional migraine preventive therapy should consider the frequency of migraine attacks and headaches, extent of migraine-associated disability, frequency of using acute migraine treatments and the responsiveness to such treatments, and patient preferences...
August 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/30074548/acute-treatment-of-migraine
#17
Bert B Vargas
PURPOSE OF REVIEW: This article provides a framework to help providers formulate a plan for the acute treatment of migraine. Topics covered include the cost-effective patient-centered approach known as stratified care and a summary of evidence-based treatment options that are currently available. Strategies for improving treatment response, troubleshooting suboptimal results, and addressing the needs of special populations are also reviewed. RECENT FINDINGS: Both the American Headache Society and the Canadian Headache Society have released evidence-based assessments and reviews of acute treatments for migraine that can be used to help guide treatment decisions...
August 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/30073574/bath-related-headache
#18
REVIEW
Aliza Kumpinsky, Stephanie J Nahas
PURPOSE OF REVIEW: The purpose of this review is to summarize the most up-to-date literature on bath-related headache, a rare disorder. RECENT FINDINGS: Initially described in middle-aged Asian women, it is now reported in a wider demographic. More information is available about the pathophysiology of bath-related headache, including its classification as a subtype of reversible cerebral vasoconstriction syndrome (RCVS). Nimodipine can be effective in patients both with and without vasospasm...
August 2, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/30073545/strides-toward-better-understanding-of-post-traumatic-headache-pathophysiology-using-animal-models
#19
REVIEW
Dara Bree, Dan Levy
PURPOSE OF REVIEW: In recent years, the awareness of the detrimental impact of concussion and mild traumatic brain injuries (mTBI) is becoming more apparent. Concussive head trauma results in a constellation of cognitive and somatic symptoms of which post-traumatic headache is the most common. Our understanding of post-traumatic headache is limited by the paucity of well validated, characterized, and clinically relevant animal models with strong predictive validity. In this review, we aim to summarize and discuss current animal models of concussion/mTBI and related data that start to shed light on the pathophysiology of post-traumatic headache...
August 2, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/30072229/spontaneous-intracranial-hypotension-due-to-sacral-diverticula-two-case-history-and-a-pocket-sized-review
#20
Francesco Cultrera, Giorgio Lofrese, Maria Teresa Nasi
Spontaneous intracranial hypotension is an increasingly recognized cause of atypical, secondary headaches. Nevertheless, its clinical and imaging spectrum is far from an exhaustive definition, ranging from straightforward cases with unambiguous findings and prompt response to treatment to more challenging ones, requiring advanced, more complex imaging and targeted therapies. We describe two unusual cases as a cue to draw a literature-based, practical approach to the management of the syndrome.
July 30, 2018: Neurocirugía
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