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https://www.readbyqxmd.com/read/30321994/generation-of-a-3d-liver-model-comprising-human-extracellular-matrix-in-an-alginate-gelatin-based-bioink-by-extrusion-bioprinting-for-infection-and-transduction-studies
#1
Thomas Hiller, Johanna Berg, Laura Elomaa, Viola Röhrs, Imran Ullah, Katrin Schaar, Ann-Christin Dietrich, Munir A Al-Zeer, Andreas Kurtz, Andreas C Hocke, Stefan Hippenstiel, Henry Fechner, Marie Weinhart, Jens Kurreck
Bioprinting is a novel technology that may help to overcome limitations associated with two-dimensional (2D) cell cultures and animal experiments, as it allows the production of three-dimensional (3D) tissue models composed of human cells. The present study describes the optimization of a bioink composed of alginate, gelatin and human extracellular matrix (hECM) to print human HepaRG liver cells with a pneumatic extrusion printer. The resulting tissue model was tested for its suitability for the study of transduction by an adeno-associated virus (AAV) vector and infection with human adenovirus 5 (hAdV5)...
October 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30321313/differences-in-the-impact-of-pneumococcal-serotype-replacement-in-individuals-with-and-without-underlying-medical-conditions
#2
Daniel M Weinberger, Joshua L Warren, Tine Dalby, Eugene D Shapiro, Palle Valentiner-Branth, Hans-Christian Slotved, Zitta Barrella Harboe
Background: Pneumococcal conjugate vaccines (PCVs) have had a well-documented impact on the incidence of invasive pneumococcal disease (IPD). However, declines in IPD due to vaccine-targeted serotypes have been partially offset by increases in IPD due to non-vaccine serotypes (NVT). The goal of this study was to quantify serotype-specific changes in the incidence of IPD that occurred in different age groups, with or without certain co-morbidities, following the introduction of PCV7 and PCV13 in the childhood vaccination program in Denmark...
October 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30321240/streptococcal-lancefield-polysaccharides-are-critical-cell-wall-determinants-for-human-group-iia-secreted-phospholipase-a2-to-exert-its-bactericidal-effects
#3
Vincent P van Hensbergen, Elin Movert, Vincent de Maat, Christian Lüchtenborg, Yoann Le Breton, Gérard Lambeau, Christine Payré, Anna Henningham, Victor Nizet, Jos A G van Strijp, Britta Brügger, Fredric Carlsson, Kevin S McIver, Nina M van Sorge
Human Group IIA secreted phospholipase A2 (hGIIA) is an acute phase protein with bactericidal activity against Gram-positive bacteria. Infection models in hGIIA transgenic mice have suggested the importance of hGIIA as an innate defense mechanism against the human pathogens Group A Streptococcus (GAS) and Group B Streptococcus (GBS). Compared to other Gram-positive bacteria, GAS is remarkably resistant to hGIIA activity. To identify GAS resistance mechanisms, we exposed a highly saturated GAS M1 transposon library to recombinant human hGIIA and compared relative mutant abundance with library input through transposon-sequencing (Tn-seq)...
October 15, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/30320596/selective-neuronal-uptake-and-distribution-of-aavrh8-aav9-and-aavrh10-in-sheep-after-intra-striatal-administration
#4
Erica Mondo, Richard Moser, Guangping Gao, Christian Mueller, Miguel Sena-Esteves, Ellen Sapp, Edith Pfister, Denice O'Connell, Kendra Takle, Kirsten E Erger, Wanglin Liu, Thomas J Conlon, Marian DiFiglia, Matthew J Gounis, Neil Aronin
BACKGROUND: Transgenic sheep are currently the only large animal model of Huntington's disease expressing full-length mutant human huntingtin. These transgenic sheep provide an opportunity to test adeno associated virus (AAV) therapies directly targeting the huntingtin gene. A recent study demonstrated that self-complementary (sc) AAV with artificial miRNA against human huntingtin reduced mutant human huntingtin in caudate and putamen after a single injection near the internal capsule...
September 29, 2018: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/30317897/severe-non-specific-symptoms-in-non-typhoidal-salmonella-infections-in-adult-patients-with-sickle-cell-disease-a-retrospective-multicentre-study
#5
Romain Guery, Anoosha Habibi, Jean-Benoît Arlet, François Lionnet, Victoire de Lastours, Jean-Winoc Decousser, Jean-Luc Mainardi, Keyvan Razazi, Laurence Baranes, Pablo Bartolucci, Bertrand Godeau, Fréderic Galacteros, Marc Michel, Matthieu Mahevas
BACKGROUND: Non-typhoidal salmonellosis (NTS) often occurs in children with sickle-cell disease (SCD) and remains a significant cause of mortality in developing countries. However, there is lack of reports on the clinical presentation, outcome and complications of NTS in adults with SCD. METHODS: We performed a chart review between 2006 and 2016 of adults SCD diagnosed with NTS in 3 referral centers monitoring approximately 3500 SCD adults. RESULTS: Twenty-three episodes of NTS were diagnosed among 22 SCD adults...
October 14, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/30316885/metagenomic-identification-and-sequence-analysis-of-a-teschovirus-a-related-virus-in-porcine-feces-in-japan-2014-2016
#6
Mami Oba, Yuki Naoi, Mika Ito, Tsuneyuki Masuda, Yukie Katayama, Shoichi Sakaguchi, Tsutomu Omatsu, Tetsuya Furuya, Hiroshi Yamasato, Fujiko Sunaga, Shinji Makino, Tetusya Mizutani, Makoto Nagai
Porcine Teschoviruses (PTVs) are associated with polioencephalomyelitis and various diseases, including reproductive and gastrointestinal disorders, of pigs and wild boars, and are also detected in the feces of healthy pigs. The genus Teschovirus contains a single species Teschovirus A that currently includes 13 serotypes. In the present study, we identified novel PTVs that are distantly related to Teschovirus A and were found in fecal samples of pigs with or without diarrhea in Japan. Phylogenetic analysis of amino acid (aa) sequences of the complete coding region revealed that these newly identified viruses did not cluster with any strains of PTVs or other strains within the picornavirus supergroup 1, suggesting that the viruses may not belong to Teschovirus A or any genus of the family Picornaviridae...
October 11, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/30316206/the-role-of-particular-ticks-developmental-stages-in-the-circulation-of-tick-borne-pathogens-in-central-europe-5-borreliaceae
#7
Grzegorz Karbowiak, Beata Biernat, Joanna Stańczak, Joanna Werszko,, Tomasz Szewczyk, Hubert Sytykiewicz
The developmental cycles of all B. burgdorferi s.l. genospecies present typical, main pattern described in the 90thies. The simple scheme might be modified according to the biology of species and hosts preference. Central European genospecies of B. burgdorferi s.l. can be associated with four groups of hosts playing the role of animal reservoirs. The group 1 contains genospecies associated with rodents as primary animal reservoir – B. afzelii, B. garinii, B. burgdorferi sensu stricto, strains B. bavariensis (B...
2018: Annals of Parasitology
https://www.readbyqxmd.com/read/30314348/antibiotic-resistant-salmonella-in-the-food-supply-and-the-potential-role-of-antibiotic-alternatives-for-control
#8
REVIEW
Divek V T Nair, Kumar Venkitanarayanan, Anup Kollanoor Johny
Salmonella enterica is one of the most ubiquitous enteropathogenic bacterial species on earth, and comprises more than 2500 serovars. Widely known for causing non-typhoidal foodborne infections (95%), and enteric (typhoid) fever in humans, Salmonella colonizes almost all warm- and cold-blooded animals, in addition to its extra-animal environmental strongholds. The last few decades have witnessed the emergence of highly virulent and antibiotic-resistant Salmonella , causing greater morbidity and mortality in humans...
October 11, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/30312379/impact-of-13-pneumococcal-conjugate-vaccine-among-adults-a-systematic-review-and-meta-analysis
#9
Nirma Khatri Vadlamudi, Anna Chen, Fawziah Marra
BACKGROUND: A notable reduction of pneumococcal disease burden among adults was observed after introduction of 7 valent- pneumococcal conjugate vaccine in childhood immunization programs. In 2010, 13 valent-pneumococcal conjugate vaccine (PCV13) replaced PCV7 in many jurisdictions; a comparative assessment of PCV13's impact has not yet been performed. OBJECTIVE: To summarize available data and assess the change in the incidence of invasive pneumococcal disease (IPD) in adults after the introduction of PCV13 in childhood immunization programs...
October 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30312265/maternal-carriage-of-group-b-streptococcus-and-escherichia-coli-in-a-district-hospital-in-mozambique
#10
Lola Madrid, Sonia Amós Maculuve, Alba Vilajeliu, Emma Sáez, Sergio Massora, Anelsio Cossa, Rosauro Varo, Antonio Sitoe, Noraida Mosqueda, Rui Anselmo, Khatia Munguambe, Sara M Soto, Cinta Moraleda, Eusebio Macete, Clara Menéndez, Quique Bassat
BACKGROUND: In low-income countries, data on prevalence and effects of group B Streptococcus (GBS) and Escherichia coli (E. coli) colonization among pregnant women are scarce, but necessary to formulate prevention strategies. We assessed prevalence of GBS and E. coli colonization and factors associated among pregnant women, its effect in newborns and acceptability regarding the utilized sampling methods in a semirural Mozambican hospital. METHODS: Pregnant women were recruited from June 2014 to January 2015, during routine antenatal clinics at gestational age ≥ 34 weeks (n = 200); or upon delivery (n = 120)...
November 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/30309744/a-single-dose-of-african-horse-sickness-virus-ahsv-vp2-based-vaccines-provides-complete-clinical-protection-in-a-mouse-model
#11
Mine Aksular, Eva Calvo-Pinilla, Alejandro Marín-López, Javier Ortego, Adam C Chambers, Linda A King, Javier Castillo-Olivares
African horse sickness is a severe, often fatal, arboviral disease of equids. The control of African horse sickness virus (AHSV) in endemic countries is based currently on the use of live attenuated vaccines despite some biosafety concerns derived from its biological properties. Thus, experimental vaccination platforms have been developed over the years in order to avoid the biosafety concerns associated with the use of attenuated vaccines. Various studies showed that baculovirus-expressed AHSV-VP2 or modified Vaccinia Ankara virus expressing AHSV-VP2 (MVA-VP2) induced virus neutralising antibodies and protective immunity in small animals and horses...
October 8, 2018: Vaccine
https://www.readbyqxmd.com/read/30309390/safety-and-immunogenicity-of-plant-produced-african-horse-sickness-virus-like-particles-in-horses
#12
Susan J Dennis, Martha M O'Kennedy, Daria Rutkowska, Tsepo Tsekoa, Carina W Lourens, Inga I Hitzeroth, Ann E Meyers, Edward P Rybicki
African horse sickness (AHS) is caused by multiple serotypes of the dsRNA AHSV and is a major scourge of domestic equids in Africa. While there are well established commercial live attenuated vaccines produced in South Africa, risks associated with these have encouraged attempts to develop new and safer recombinant vaccines. Previously, we reported on the immunogenicity of a plant-produced AHS serotype 5 virus-like particle (VLP) vaccine, which stimulated high titres of AHS serotype 5-specific neutralizing antibodies in guinea pigs...
October 11, 2018: Veterinary Research
https://www.readbyqxmd.com/read/30307674/spatio-temporal-distribution-of-vertically-transmitted-dengue-viruses-by-aedes-aegypti-diptera-culicidae-from-arroyo-naranjo-havana-cuba
#13
Gladys Gutiérrez-Bugallo, Rosmari Rodríguez-Roche, Gisell Díaz, Magaly Pérez, María Elena Mendizábal, Iris Peraza, Antonio A Vázquez, Mayling Alvarez, Magdalena Rodríguez, Juan A Bisset, María G Guzmán
OBJECTIVE: To study the distribution of vertical transmission of dengue viruses in field-collected Aedes aegypti larvae in the municipality of Arroyo Naranjo in Havana, Cuba. METHODS: Ae. aegypti larvae and pupae were collected monthly between September 2013 and July 2014 in the seven Municipal Health Areas of Arroyo Naranjo. Pools formed of 30-55 larvae were examined through PCR and sequencing to detect the presence of each serotype. RESULTS: We analyzed 111 pools of larvae and pupae (4102 individuals) of which 37 tested positive for at least one DENV...
October 11, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/30306254/patterns-of-the-initiation-of-disease-modifying-antirheumatic-drugs-in-incident-rheumatoid-arthritis-a-german-perspective-based-on-nationwide-ambulatory-drug-prescription-data
#14
Annika Steffen, Jakob Holstiege, Kerstin Klimke, Manas K Akmatov, Jörg Bätzing
This study aimed at providing a current and nearly complete picture of the patterns of the initiation of disease-modifying antirheumatic drugs (DMARDs) in patients with newly diagnosed RA. Based on ambulatory drug prescription data and physician billing claims data covering 87% of the German population, we assembled a cohort of incident RA patients aged 15-79 years (n = 54,896) and assessed the prescription frequency of total DMARDs, conventional synthetic (csDMARDs) and biologic DMARDs (bDMARDs) within the first year of disease...
October 10, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30305531/-development-of-gene-therapy-for-hemophilia-current-states-and-future-perspectives
#15
Tsukasa Ohmori
Hemophilia is congenital hemorrhagic disease due to genetic abnormality of blood coagulation factor VIII or factor IX. Hemophilia appears suitable for gene therapy because it is caused by a single gene abnormality, and therapeutic coagulation factor levels vary across a broad range. Since the success of gene therapy eliminates the need for regular administration of factor concentrates, the development has been met with great expectation from patients and their families. In fact, several clinical trials using adeno-associated virus (AAV) vectors have been started in Western countries, and long-term therapeutic effect could be obtained by single injection...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/30305321/discovery-of-mcr-1-mediated-colistin-resistance-in-a-highly-virulent-escherichia-coli-lineage
#16
Brian M Forde, Hosam M Zowawi, Patrick N A Harris, Leah Roberts, Emad Ibrahim, Nissar Shaikh, Anand Deshmukh, Mazen A Sid Ahmed, Muna Al Maslamani, Kyra Cottrell, Ella Trembizki, Lana Sundac, Heidi H Yu, Jian Li, Mark A Schembri, David M Whiley, David L Paterson, Scott A Beatson
Resistance to last-line polymyxins mediated by the plasmid-borne mobile colistin resistance gene ( mcr-1 ) represents a new threat to global human health. Here we present the complete genome sequence of an mcr-1 -positive multidrug-resistant Escherichia coli strain (MS8345). We show that MS8345 belongs to serotype O2:K1:H4, has a large 241,164-bp IncHI2 plasmid that carries 15 other antibiotic resistance genes (including the extended-spectrum β-lactamase bla CTX-M-1 ) and 3 putative multidrug efflux systems, and contains 14 chromosomally encoded antibiotic resistance genes...
October 10, 2018: MSphere
https://www.readbyqxmd.com/read/30303441/response-to-pcv13-vaccination-in-patients-with-multiple-myeloma-versus-healthy-controls
#17
S Shahzad Mustafa, Deep Shah, Jonathan Bress, Saad Jamshed
Infections are a major cause of morbidity and mortality in individuals with multiple myeloma (MM). These individuals exhibit humoral dysfunction and show a suboptimal response to pneumococcal polysaccharide vaccine (PPV23). Since pneumococcal conjugate vaccine (PCV13) elicits a T cell dependent response, it is recommended in patients with multiple myeloma. This study compares the initial response to PCV13 and durability of the response at 6 months in patients with multiple myeloma versus normal controls. Seven patients with multiple myeloma and 18 control patients were enrolled in the study...
October 10, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/30303436/coadministration-of-13-valent-pneumococcal-conjugate-and-quadrivalent-inactivated-influenza-vaccines-in-adults-previously-immunized-with-polysaccharide-pneumococcal-vaccine-23-a-randomized-clinical-trial
#18
Allison R Thompson, Nicola P Klein, H Jackson Downey, Scott Patterson, Vani Sundaraiyer, Wendy Watson, Keri Clarke, Kathrin U Jansen, Shite Sebastian, William C Gruber, Daniel A Scott, Beate Schmoele-Thoma
Immune responses to 13-valent pneumococcal conjugate vaccine (PCV13) and quadrivalent inactivated influenza vaccine (QIV) in older adults may vary with coadministration and previous pneumococcal polysaccharide vaccination. This study assessed safety and noninferiority of immune responses to coadministered PCV13 and QIV compared with each vaccine given alone. Adults ≥50 years old preimmunized with ≥1 dose of 23-valent pneumococcal polysaccharide vaccine (PPSV23) ≥1 year before enrollment were randomized 1:1 to receive PCV13+QIV then placebo 1 month later or placebo+QIV then PCV13 1 month later...
October 10, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/30301880/dengue-virus-and-the-host-innate-immune-response
#19
REVIEW
Naoko Uno, Ted M Ross
Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There are four serotypes of the virus. Each serotype is antigenically different, meaning they elicit heterologous antibodies. Infection with one serotype will create neutralizing antibodies to the serotype. Cross-protection from other serotypes is not long term, instead heterotypic infection can cause severe disease. This review will focus on the innate immune response to DENV infection and the virus evasion of the innate immune system by escaping recognition or inhibiting the production of an antiviral state...
October 10, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/30301701/co-infection-between-zika-and-different-dengue-serotypes-during-denv-outbreak-in-brazil
#20
Cássia F Estofolete, Ana C B Terzian, Tatiana E Colombo, Georgia de Freitas Guimarães, Helio C Ferraz, Rafael A da Silva, Gilmar V Greque, Maurício L Nogueira
BACKGROUND: The recent introduction of new arboviruses in the Americas, as Zika virus (ZIKV) and Chikungunya virus (CHIKV), increased the risk of outbreaks and arboviral co-infections. Herein, we report twelve cases of co-infection of ZIKV and different DENV serotypes in a city located in the northwest region of São Paulo State, Brazil, which is hyper-endemic to Dengue. METHODS: Between January and November 2016, 1254 suspected cases of arboviral infection were available by our surveillance program in São José do Rio Preto...
October 6, 2018: Journal of Infection and Public Health
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