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JOURNAL ARTICLE
Tiago Pinto, Neftalí Sillero, António Mira, Sara M Santos
Roads represent one of the main sources of wildlife mortality, population decline, and isolation, especially for low-vagility animal groups. It is still not clearly understood how wildlife populations respond to these negative effects over space and time. Most studies on wildlife road mortality do not consider the spatial and temporal components simultaneously, or the imperfect roadkill detection, both of which could lead to inaccurate assumptions and unreliable mitigation actions. In this study, we applied a multi-season occupancy model to a 14-year amphibian mortality dataset collected along 120 km of roads, combined with freely available landscape and remote sensing metrics, to identify the spatiotemporal patterns of amphibian roadkill in a Mediterranean landscape in Southern Portugal...
April 11, 2024: Science of the Total Environment
#22
JOURNAL ARTICLE
Stefan Knirck, Gabe Hoshino, Mohamed H Awida, Gustavo I Cancelo, Martin Di Federico, Benjamin Knepper, Alex Lapuente, Mira Littmann, David W Miller, Donald V Mitchell, Derrick Rodriguez, Mark K Ruschman, Matthew A Sawtell, Leandro Stefanazzi, Andrew Sonnenschein, Gary W Teafoe, Daniel Bowring, G Carosi, Aaron Chou, Clarence L Chang, Kristin Dona, Rakshya Khatiwada, Noah A Kurinsky, Jesse Liu, Cristián Pena, Chiara P Salemi, Christina W Wang, Jialin Yu
We present first results from a dark photon dark matter search in the mass range from 44 to 52 μeV (10.7-12.5 GHz) using a room-temperature dish antenna setup called GigaBREAD. Dark photon dark matter converts to ordinary photons on a cylindrical metallic emission surface with area 0.5 m^{2} and is focused by a novel parabolic reflector onto a horn antenna. Signals are read out with a low-noise receiver system. A first data taking run with 24 days of data does not show evidence for dark photon dark matter in this mass range, excluding dark photon photon mixing parameters χ≳10^{-12} in this range at 90% confidence level...
March 29, 2024: Physical Review Letters
#23
JOURNAL ARTICLE
Cinzia Cocola, Edoardo Abeni, Valentina Martino, Eleonora Piscitelli, Paride Pelucchi, Ettore Mosca, Alice Chiodi, Tasnim Mohamed, Mira Palizban, Giovanni Porta, Helga Palizban, Giovanni Nano, Francesco Acquati, Antonino Bruno, Burkhard Greve, Daniela Gerovska, Valerio Magnaghi, Daniela Mazzaccaro, Giovanni Bertalot, James Kehler, Cristiana Balbino, Marcos J Arauzo-Bravo, Martin Götte, Ileana Zucchi, Rolland A Reinbold
High-grade gliomas (HGGs) and glioblastoma multiforme (GBM) are characterized by a heterogeneous and aggressive population of tissue-infiltrating cells that promote both destructive tissue remodeling and aberrant vascularization of the brain. The formation of defective and permeable blood vessels and microchannels and destructive tissue remodeling prevent efficient vascular delivery of pharmacological agents to tumor cells and are the significant reason why therapeutic chemotherapy and immunotherapy intervention are primarily ineffective...
April 3, 2024: International Journal of Molecular Sciences
#24
JOURNAL ARTICLE
Wen-Jui Yang, Farn Lu, Cai-Yun Wang, Jun-Jie Hong, Tiffany Wang, Pok Eric Yang, Jack Yu-Jen Huang
Despite serum progesterone being a widely accepted method for luteal phase support during embryo transfer cycles, debates persist regarding the optimal strategy for guiding clinical decisions on progesterone dosages to maximize reproductive outcomes. This retrospective study explored the utility of microRNA (miRNA) biomarkers in guiding personalized progesterone dosage adjustments for frozen embryo transfer (FET) cycles in 22 in vitro fertilization (IVF) patients undergoing hormone replacement therapy. Utilizing MIRA, an miRNA-based endometrial receptivity test, we analyzed patients' miRNA expression profiles before and after progesterone dosage adjustments to determine suitable dosages and assess endometrial status...
March 25, 2024: International Journal of Molecular Sciences
#25
JOURNAL ARTICLE
Yasmina Elmahboub, Rofida Albash, Mira Magdy William, Amal H Rayan, Najat O Hamed, Mona S Ousman, Nahed A Raslan, Shaimaa Mosallam
Metformin (MET), an antidiabetic drug, is emerging as a promising anticancer agent. This study was initiated to investigate the antitumor effects and potential molecular targets of MET in mice bearing solid Ehrlich carcinoma (SEC) as a model of breast cancer (BC) and to explore the potential of zein nanoparticles (ZNs) as a carrier for improving the anticancer effect of MET. ZNs were fabricated through ethanol injection followed by probe sonication method. The optimum ZN formulation (ZN8) was spherical and contained 5 mg zein and 30 mg sodium deoxycholate with a small particle size and high entrapment efficiency percentage and zeta potential...
April 3, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#26
JOURNAL ARTICLE
Gyuri Kim, Tae Yang Yu, Jae Hwan Jee, Ji Cheol Bae, Mira Kang, Jae Hyeon Kim
AIM: Left ventricular diastolic dysfunction (LVDD) has been observed in people with nonalcoholic fatty liver disease (NAFLD) in cross-sectional studies but the causal relationship is unclear. This study aimed to investigate the impact of NAFLD and the fibrotic progression of the disease on the development of LVDD, assessed by serial echocardiography, in a large population over a 7-year longitudinal setting. METHODS: This retrospective cohort study included the data of 3,496 subjects from a medical health check-up program...
April 10, 2024: Diabetes & Metabolism
#27
JOURNAL ARTICLE
Yuhao Qiang, Mengjia Xu, Mira Patel Pochron, Madhulika Jupelli, Ming Dao
The occurrence of vaso-occlusive crisis greatly depends on the competition between the sickling delay time and the transit time of individual sickle cells, i.e., red blood cells (RBCs) from sickle cell disease (SCD) patients, while they are traversing the circulatory system. Many drugs for treating SCD work by inhibiting the polymerization of sickle hemoglobin (HbS), effectively delaying the sickling process in sickle cells (SS RBCs). Most previous studies on screening anti-sickling drugs, such as voxelotor, rely on in vitro testing of sickling characteristics, often conducted under prolonged deoxygenation for up to 1 hour...
2024: Frontiers in Physics
#28
EDITORIAL
Mirae Park, Giovanni Satta, Pranabashis Haldar
No abstract text is available yet for this article.
April 10, 2024: Thorax
#29
JOURNAL ARTICLE
Marie-Pier St-Laurent, George Acland, Sarah N Hamilton, Jeremy Hamm, Katherine Sunderland, Peter C Black, Michael McKenzie, Mira Keyes, Stacy Miller, Martin E Gleave, Scott Tyldesley
PURPOSE: Second malignancy is a rare but potentially lethal event after prostate brachytherapy, but data remain scarce on its long-term risk. The objective of this study is to estimate the number of pelvic second malignancies following brachytherapy compared to prostatectomy (RP). MATERIALS AND METHODS: Retrospective review of patients treated with low dose 125 I brachytherapy and prostatectomy in British Columbia from 1999 to 2010. Kaplan Meier (KM) estimates for pelvic (bladder and rectum), invasive pelvic, any second malignancy and death from any second malignancy were assessed...
April 11, 2024: Journal of Urology
#30
JOURNAL ARTICLE
Raffaella De Pace, Saikat Ghosh, Veronica H Ryan, Mira Sohn, Michal Jarnik, Paniz Rezvan Sangsari, Nicole Y Morgan, Ryan K Dale, Michael E Ward, Juan S Bonifacino
In neurons, RNA granules are transported along the axon for local translation away from the soma. Recent studies indicate that some of this transport involves hitchhiking of RNA granules on lysosome-related vesicles. In the present study, we leveraged the ability to prevent transport of these vesicles into the axon by knockout of the lysosome-kinesin adaptor BLOC-one-related complex (BORC) to identify a subset of axonal mRNAs that depend on lysosome-related vesicles for transport. We found that BORC knockout causes depletion of a large group of axonal mRNAs mainly encoding ribosomal and mitochondrial/oxidative phosphorylation proteins...
April 10, 2024: Nature Neuroscience
#31
JOURNAL ARTICLE
Felix Dewald, Gertrud Steger, Irina Fish, Ivonne Torre-Lage, Christina Hellriegel, Esther Milz, Anja Kolb-Bastigkeit, Eva Heger, Mira Fries, Michael Buess, Niklas Marizy, Barbara Michaelis, Isabelle Suárez, Gibran Horemheb Rubio Quintanares, Martin Pirkl, Annette Aigner, Max Oberste, Martin Hellmich, Anabelle Wong, Juan Camilo Orduz, Gerd Fätkenheuer, Jörg Dötsch, Annelene Kossow, Eva-Maria Moench, Gustav Quade, Udo Neumann, Rolf Kaiser, Madlen Schranz, Florian Klein
BACKGROUND AND OBJECTIVES: Test-to-stay concepts apply serial testing of children in daycare after exposure to SARS-CoV-2 without use of quarantine. This study aims to assess the safety of a test-to-stay screening in daycare facilities. METHODS: 714 daycare facilities and approximately 50 000 children ≤6 years in Cologne, Germany participated in a SARS-CoV-2 Pool-polymerase chain reaction (PCR) screening from March 2021 to April 2022. The screening initially comprised post-exposure quarantine and was adapted to a test-to-stay approach during its course...
April 10, 2024: Pediatrics
#32
JOURNAL ARTICLE
Seema P Anandalwar, Lindsay O'Meara, Roumen Vesselinov, Ashling Zhang, Jeffrey N Baum, Amanda Cooper, Cassandra Decker, Thomas Schroeppel, Jenny Cai, Daniel Cullinane, Richard D Catalano, Nikolay Bugaev, Madison LeClair, Christina Feather, Katherine McBride, Valerie Sams, Pak Shan Leung, Samantha Olafson, Devon S Callahan, Joseph Posluszny, Simon Moradian, Jordan Estroff, Beth Hochman, Natasha Coleman, Anna Goldenberg-Sandau, Jeffry Nahmias, Kathryn Rosenbaum, Jason Pasley, Lindsay Boll, Leah Hustad, Jessica Reynolds, Michael Truitt, Mira Ghneim
INTRODUCTION: To assess perioperative bleeding complications & in-hospital mortality in patients requiring emergency general surgery (EGS) presenting with a history of antiplatelet (AP) vs. direct oral anticoagulant (DOAC) vs warfarin use. METHODS: Prospective observational study across 21 centers between 2019-2022. Inclusion criteria were age ≥ 18 years, & DOAC, warfarin or AP use within 24 hours of an EGSP. Outcomes included perioperative bleeding and in-hospital mortality...
April 10, 2024: Journal of Trauma and Acute Care Surgery
#33
JOURNAL ARTICLE
Mira A Atkinson, Jessica J James, Meagan E Quinn, Jonathon W Senefeld, Sandra K Hunter
PURPOSE: To understand athletic performance before and after puberty, this study determined: 1) the age at which the sex difference increases among elite youth track and field athletes for running and jumping events; and 2) whether there is a sex difference in performance prior to ages associated with puberty among elite youth athletes. METHODS: Track and field records of elite USA male and female youth (7-18 years) across three years (2019, 2021, and 2022) were collected from an online database ( athletic...
April 10, 2024: Medicine and Science in Sports and Exercise
#34
JOURNAL ARTICLE
Maya Ronse, Thuan Thi Nguyen, Xa Xuan Nguyen, Brecht Ingelbeen, Mira Leonie Schneiders, Duong Thanh Tran, Joan Muela Ribera, Charlotte Gryseels, Koen Peeters Grietens
Despite the global threat of antimicrobial resistance (AMR), evidence on the use and quality of medicines at community level is limited, particularly in impoverished, rural areas where prevalence of (bacterial) infections is high. To better understand the processes that drive vulnerability to AMR' effects, this study aimed to assess social factors underpinning access to-and use of-medical products and healthcare, among people from the Raglai ethnic minority in Ninh Thuan Province, Vietnam. We conducted ethnographic research in eight villages in 2018-2019, using interviewing and participant observation methods for data collection...
2024: PLOS Glob Public Health
#35
JOURNAL ARTICLE
Zosia Goossens, Thomas Bilterys, Eveline Van Looveren, Anneleen Malfliet, Mira Meeus, Lieven Danneels, Kelly Ickmans, Barbara Cagnie, Aurore Roland, Maarten Moens, Jo Nijs, Liesbet De Baets, Olivier Mairesse
(1) Background : This exploratory study aims to explore the relationship between nonspecific chronic spinal pain (nCSP) and insomnia symptoms, by examining the interconnections, strengths, and directional dependence of the symptoms. In addition, we aim to identify the key symptoms of the nCSP-insomnia relationship and shed light on the bidirectional nature of this relationship. (2) Methods : This study is a secondary analysis of the baseline data (cross-sectional) from a randomized controlled trial, which examined the added value of Cognitive Behavioral Therapy for Insomnia (CBT-I) combined with cognition-targeted exercise therapy, conducted in collaboration with the Universiteit Gent and Vrije Universiteit Brussel (Belgium)...
March 2, 2024: Journal of Clinical Medicine
#36
JOURNAL ARTICLE
Mira T Tanenbaum, Andres V Figueroa, K Benjamin Lee, Jose Eduardo Costa Filho, Marilisa Soto Gonzalez, Mirza S Baig, Carlos H Timaran
OBJECTIVE: Endovascular repair of chronic dissecting aortoiliac aneurysms is challenging given the rigid septum, compressed true lumen (TL), and target vessels frequently originating in the false lumen. We have used transcatheter electrosurgical aortic septotomy (TEAS) before stent graft implantation under intravascular ultrasound (IVUS) and fusion guidance. The purpose of this study is to assess the outcomes of TEAS during complex endovascular repair of dissecting aneurysms. METHODS: From 2021 to 2023, 17 patients underwent TEAS...
June 2024: Journal of Vascular Surgery Cases and Innovative Techniques
#37
JOURNAL ARTICLE
José Joaquín Mira, Valerie Matarredona, Susanna Tella, Paulo Sousa, Vanessa Ribeiro Neves, Reinhard Strametz, Adriana López-Pineda
BACKGROUND: When healthcare students witness, engage in, or are involved in an adverse event, it often leads to a second victim experience, impacting their mental well-being and influencing their future professional practice. This study aimed to describe the efforts, methods, and outcomes of interventions to help students in healthcare disciplines cope with the emotional experience of being involved in or witnessing a mistake causing harm to a patient during their clerkships or training...
April 8, 2024: BMC Medical Education
#38
JOURNAL ARTICLE
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer Roth, Matthew Rees, Melissa Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
RAS oncogenes (collectively NRAS, HRAS and especially KRAS) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 and 611 . Small molecule inhibitors of the KRAS(G12C) oncoprotein have demonstrated clinical efficacy in patients with multiple cancer types and have led to regulatory approvals for the treatment of non-small cell lung cancer2,3 . Nevertheless, KRASG12C mutations account for only around 15% of KRAS-mutated cancers4,5 , and there are no approved KRAS inhibitors for the majority of patients with tumours containing other common KRAS mutations...
April 8, 2024: Nature
#39
JOURNAL ARTICLE
Viviana Ostrovsky, Mira Ulman, Rina Hemi, Samuel Lurie, Inon Hazan, Alon Ben Ari, Oleg Sukmanov, Tal Schiller, Alena Kirzhner, Taiba Zornitzki
SUMMARY: Total testosterone, which is peripherally converted to its biologically active form dihydrotestosterone (DHT), is the first-line hormone investigation in hyperandrogenic states and infertility in premenopausal women. Polycystic ovary syndrome (PCOS), the most common cause of hyperandrogenism and infertility in young women, is often associated with mild elevations of total testosterone. Whereas very high levels of total testosterone (>2-3 SD of normal reference), are most often associated with hyperandrogenic signs, menstrual irregularity, rapid onset of virilization, and demand a prompt investigation...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
#40
JOURNAL ARTICLE
Salome Rudin, Lilian Kriemler, Tolga D Dittrich, Annaelle Zietz, Juliane Schweizer, Markus Arnold, Nils Peters, Filip Barinka, Simon Jung, Marcel Arnold, Urs Fischer, Katharina Rentsch, Mirjam Christ-Crain, Mira Katan, Gian Marco De Marchis
BACKGROUND: Lipoprotein (a) [Lp(a)] serum levels are highly genetically determined and promote atherogenesis. High Lp(a) levels are associated with increased cardiovascular morbidity. Serum Lp(a) levels have recently been associated with large artery atherosclerosis (LAA) stroke. We aimed to externally validate this association in an independent cohort. METHODS: This study stems from the prospective multicentre CoRisk study (CoPeptin for Risk Stratification in Acute Stroke patients [NCT00878813]), conducted at the University Hospital Bern, Switzerland, between 2009 and 2011, in which Lp(a) plasma levels were measured within the first 24 hours after stroke onset...
April 2, 2024: Swiss Medical Weekly
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