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Mira Küllmar, Melanie Meersch
No abstract text is available yet for this article.
November 2018: Anesthesia and Analgesia
Kari Ann Shirey, Mary E Sunday, Wendy Lai, Mira C Patel, Jorge C G Blanco, Frank Cuttitta, Stefanie N Vogel
Gastrin-releasing peptide (GRP) is an evolutionarily well-conserved neuropeptide that was originally recognized for its ability to mediate gastric acid secretion in the gut. More recently, however, GRP has been implicated in pulmonary lung inflammatory diseases including bronchopulmonary dysplasia, chronic obstructive pulmonary disease, emphysema, and others. Antagonizing GRP or its receptor mitigated lethality associated with the onset of viral pneumonia in a well-characterized mouse model of influenza. In mice treated therapeutically with the small-molecule GRP inhibitor, NSC77427, increased survival was accompanied by decreased numbers of GRP-producing pulmonary neuroendocrine cells, improved lung histopathology, and suppressed cytokine gene expression...
October 16, 2018: Mucosal Immunology
Mira Trivedi, Amy Goldstein, Gaurav Arora
Cardiac conduction disease affects patients with Kearns-Sayre syndrome. We report a young asymptomatic patient with Kearns-Sayre syndrome with abnormal conduction on electrocardiogram and Holter monitor, although not advanced atrioventricular block. She underwent prophylactic pacemaker placement, and rapidly developed complete atrioventricular block, which resulted in 100% ventricular pacing. It may be reasonable to consider prophylactic pacemaker implantation in patients with Kearns-Sayre syndrome with evidence of cardiac conduction disease even without overt atrioventricular block given its unpredictable progression to complete atrioventricular block...
October 17, 2018: Cardiology in the Young
Andrea Polli, Jessica Van Oosterwijck, Mira Meeus, Luc Lambrecht, Jo Nijs, Kelly Ickmans
Background and aims The interaction between the immune system and pain has been thoroughly explored in the recent decades. The release of inflammatory mediators from immune cells has the capability of activating neurons and glial cells, in turn sensitizing the nervous system. Both immune system alterations and pain modulation dysfunctions have been shown in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) following exercise. However, no studies tried to explore whether these two phenomena are linked and can explain exercise-induced symptoms worsening in people with ME/CFS...
October 16, 2018: Scandinavian Journal of Pain
Claire Isbell, Stephen M Cohn, Kenji Inaba, Terence O'Keeffe, Marc De Moya, Seleshi Demissie, Mira Ghneim, Matthew L Davis
BACKGROUND: In trauma patients with cirrhosis who require laparotomy, little data exists to establish clinical predictors of the outcome. We sought to determine the prognosticators of mortality in this population. METHODS: We performed a 10-year review at four, busy Level I trauma centers of patients with cirrhosis identified during trauma laparotomy. We compared vital signs, laboratory values, and transfusion requirements for those who survived versus those who died...
August 2, 2018: Curēus
Sameer Agnihotri, Sheila Mansouri, Kelly Burrell, Mira Li, Yasin Mamatjan, Jeff C Liu, Romina Nejad, Sushil Kumar, Shahrzad Jalali, Sanjay Singh, Alenoush Vartanian, Eric X Chen, Shirin Karimi, Olivia Singh, Severa Bunda, Alireza Mansouri, Kenneth Aldape, Gelareh Zadeh
PURPOSE: HK2 is elevated in GBM and we have shown that HK2 could serve as an effective therapeutic target for GBM. Here, we interrogated compounds that target HK2 effectively and restrict tumor growth in cell lines, patient derived glioma stem cells, and mouse models of GBM. EXPERIMENTAL DESIGN: We performed a screen using a set of 15 drugs that were predicted to inhibit the HK2 associated gene signature. We next determined the EC50 of the compounds by treating glioma cell lines and glioma stem cells...
October 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Lorraine Johnson, Mira Shapiro, Jennifer Mankoff
Lyme disease is caused by the bacteria borrelia burgdorferi and is spread primarily through the bite of a tick. There is considerable uncertainty in the medical community regarding the best approach to treating patients with Lyme disease who do not respond fully to short-term antibiotic therapy. These patients have persistent Lyme disease symptoms resulting from lack of treatment, under-treatment, or lack of response to their antibiotic treatment protocol. In the past, treatment trials have used small restrictive samples and relied on average treatment effects as their measure of success and produced conflicting results...
October 12, 2018: Healthcare (Basel, Switzerland)
Sabita Rangra, Mira Kabra, Vageesh Gupta, Preeti Srivastava
Biodesulfurization is an eco-friendly process for removing sulfur from petroleum fractions. The process could not be commercialized because of the inability of microorganisms to desulfurize a wide range of heterocyclic poly aromatic sulfur compounds like dibenzothiophene (DBT), 4, 6-Dimethyl DBT present in fuel and low desulfurization activity. In the present study, to improve the rates of conversion of dibenzothiophene to dibenzothiophene sulfone, the responsible enzyme dibenzothiophene monooxygenase DszC, is displayed on the surface of Escherichia coli...
October 12, 2018: Journal of Biotechnology
Marius Ilié, Mélanie Ngo-Mai, Elodie Long-Mira, Sandra Lassalle, Catherine Butori, Coraline Bence, Marame Hamila, Véronique Hofman, Paul Hofman
Pembrolizumab monotherapy has been approved for the first- and second-line treatment of patients with PD-L1-expressing advanced non-small cell lung cancer (NSCLC). Testing for PD-L1 expression with the PD-L1 immunohistochemistry (IHC) 22C3 companion diagnostic assay, which gives a tumor proportion score (TPS), has been validated on tumor tissue. We developed an optimized laboratory-developed test (LDT) that uses the 22C3 antibody (Ab) concentrate on a widely available IHC autostainer for biopsy and cytology specimens...
September 25, 2018: Journal of Visualized Experiments: JoVE
Koen Degeling, Mira D Franken, Anne M May, Martijn G H van Oijen, Miriam Koopman, Cornelis J A Punt, Maarten J IJzerman, Hendrik Koffijberg
BACKGROUND: Individual patient data, e.g. from clinical trials, often need to be extrapolated or combined with additional evidence when assessing long-term impact in cost-effectiveness modeling studies. Different modeling methods can be used to represent the complex dynamics of clinical practice; the choice of which may impact cost-effectiveness outcomes. We compare the use of a previously designed cohort discrete-time state-transition model (DT-STM) with a discrete event simulation (DES) model...
October 11, 2018: Cancer Epidemiology
Mira Holliday, Samantha Barratt Ross, Seakcheng Lim, Christopher Semsarian
Hypertrophic cardiomyopathy is an inherited cardiomyopathy with a prevalence of up to 1 in 200, which can result in significant morbidity and mortality. An iPSC line was generated from peripheral blood mononuclear cells obtained from the whole blood of a 58-year-old male with hypertrophic cardiomyopathy who carries the heterozygous pathogenic myosin binding protein C mutation p.Arg502Trp. Induced pluripotent stem cells express pluripotency markers, demonstrate trilineage differentiation potential, and display a normal karyotype...
October 6, 2018: Stem Cell Research
Denis J Brothers
The genus Aglaotilla Brothers, gen. nov., is described for 14 striking species of Australian Mutillidae related to Ephutomorpha André, 1902, characterized by bright metallic coloration and strong punctation. The description of both sexes is possible through sex associations revealed by rearings from mud nests and trap nests. Both sexes of the type species, Ephutomorpha submetallescens Turner, 1916, are described and illustrated, the male for the first time. New combinations and a new name are proposed, as follows: Aglaotilla aeruginosa (Smith, 1879), comb...
April 30, 2018: Zootaxa
Owen D Seeman, Maria Minor, Michelle R Baker, David Evans Walter
The discovery of a new genus of Heatherellidae in New Zealand has led us to revise this enigmatic family and its constituent genera. Aheatherella n. gen., based on A. mira n. sp. from the North Island of New Zealand, lacks some of the derived character states that link the Australian Heatherella, most notably the lack of sexual dimorphism in the dorsal shields and in the presence of peritremes in adult Aheatherella. Heatherella osleri n. sp. is described from New South Wales, extending the distribution of this genus beyond Queensland...
June 18, 2018: Zootaxa
Yeong-Jun Song, Hae-Kwan Cheong, Myung Ki, Ji-Yeon Shin, Seung-Sik Hwang, Mira Park, Moran Ki, Jiseun Lim
Research has shown the effects of climatic factors on shigellosis; however, no previous study has evaluated climatic effects in regions with a winter seasonality of shigellosis incidence. We examined the effects of temperature and precipitation on shigellosis incidence in Korea from 2002⁻2010. The incidence of shigellosis was calculated based on data from the Korean Center for Disease Control and Prevention (KCDC, Cheongju, Korea), and a generalized additive model (GAM) was used to analyze the associations between the incidence and climatic factors...
October 10, 2018: International Journal of Environmental Research and Public Health
Patrick J Campbell, Mira Patel, Jennifer R Martin, Ana L Hincapie, David Rhys Axon, Terri L Warholak, Marion Slack
Importance: While much is known about hospital pharmacy error rates in the USA, comparatively little is known about community pharmacy dispensing error rates. Objective: The aim of this study was to determine the rate of community pharmacy dispensing errors in the USA. Methods: English language, peer-reviewed observational and interventional studies that reported community pharmacy dispensing error rates in the USA from January 1993 to December 2015 were identified in 10 bibliographic databases and topic-relevant grey literature...
2018: BMJ Open Quality
Saber D Barbar, Raphaël Clere-Jehl, Abderrahmane Bourredjem, Romain Hernu, Florent Montini, Rémi Bruyère, Christine Lebert, Julien Bohé, Julio Badie, Jean-Pierre Eraldi, Jean-Philippe Rigaud, Bruno Levy, Shidasp Siami, Guillaume Louis, Lila Bouadma, Jean-Michel Constantin, Emmanuelle Mercier, Kada Klouche, Damien du Cheyron, Gaël Piton, Djillali Annane, Samir Jaber, Thierry van der Linden, Gilles Blasco, Jean-Paul Mira, Carole Schwebel, Loïc Chimot, Philippe Guiot, Mai-Anh Nay, Ferhat Meziani, Julie Helms, Claire Roger, Benjamin Louart, Remi Trusson, Auguste Dargent, Christine Binquet, Jean-Pierre Quenot
BACKGROUND: Acute kidney injury is the most frequent complication in patients with septic shock and is an independent risk factor for death. Although renal-replacement therapy is the standard of care for severe acute kidney injury, the ideal time for initiation remains controversial. METHODS: In a multicenter, randomized, controlled trial, we assigned patients with early-stage septic shock who had severe acute kidney injury at the failure stage of the risk, injury, failure, loss, and end-stage kidney disease (RIFLE) classification system but without life-threatening complications related to acute kidney injury to receive renal-replacement therapy either within 12 hours after documentation of failure-stage acute kidney injury (early strategy) or after a delay of 48 hours if renal recovery had not occurred (delayed strategy)...
October 11, 2018: New England Journal of Medicine
Jack Lazerson, Judith Rosenthal, Carolyn Glaubensklee, Thomas Hunt, Bruce Morgenstern, Jayabala Pamidimukkala, David M Penn, Ken Rosenthal, Mira Sarsekeyeva, Stephanie Wragg
Medical education has evolved over time toward a model which integrates clinical medicine with the basic sciences. More recently, medical education has put an emphasis on outcome-based education. Other areas of health care education have had a similar emphasis which can provide models to inform a new model for medical education. The Roseman University of Health Sciences has developed and implemented a model based on underlying tenets of mastery learning since 1999. The model has been implemented in pharmacy, nursing, and dental education...
January 2018: Journal of Medical Education and Curricular Development
Ji-Yeon Shin, Kyoung-Hee Sohn, Ji Eun Shin, Mira Park, Jiseun Lim, Jin Yong Lee, Min-Suk Yang
This study was conducted to assess the changes in the annual incidence of adult asthma in Korea where the prevalence of asthma had increased steadily in recent decades. A population-based cohort study was conducted using the National Health Insurance Service-National Sample Cohort (NHIS-NSC), which consisted of 746,816 adults aged >20 years between 2004 and 2012. Asthma was defined by two or more physician claims on the basis of a primary diagnostic code for asthma and administration of asthma medications within 1 year...
October 9, 2018: Scientific Reports
M J Sánchez-Muros, E Morote, C Gil, J J Ramos-Miras, M Torrijos, J A Rodríguez Martin
Total liver and muscle mercury, and muscular composition, biometrics and trophic levels, were determined in four species (Mullus surmuletus, Merluccius merluccius, Auxis rochei and Scomber japonicus) of the Mediterranean Sea (Almería Bay, Spain). Mercury levels did not exceed the maximum residue limit, and M. merluccius obtained the highest level in muscle. Considerable variations in Hg content among individuals were observed in non-gregarious species. A positive correlation between Hg and trophic level or length was found in muscle, but not in liver...
October 2018: Marine Pollution Bulletin
Weihua Mao, Stephen J Gardner, Karen Chin Snyder, Ning Winston Wen, Hualiang Zhong, Haisen Li, Paul Jackson, Mira Shah, Indrin J Chetty
PURPOSE: We explore the optimal cone-beam CT (CBCT) acquisition parameters to improve CBCT image quality to enhance intracranial stereotactic radiosurgery (SRS) localization and also assess the imaging dose levels associated with each imaging protocol. METHODS: Twenty-six CBCT acquisition protocols were generated on an Edge® linear accelerator (Varian Medical Systems, Palo Alto, CA) with different x-ray tube current and potential settings, gantry rotation trajectories, and gantry rotation speeds...
October 7, 2018: Journal of Applied Clinical Medical Physics
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