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Elodie Long-Mira, Marius Ilie, Emmanuel Chamorey, Florence Leduff-Blanc, Henri Montaudié, Virginie Tanga, Maryline Allégra, Virginie Lespinet-Fabre, Olivier Bordone, Christelle Bonnetaud, Renaud Schiappa, Catherine Butori, Coraline Bence, Jean-Philippe Lacour, Véronique Hofman, Paul Hofman
The mutation status of the BRAF and NRAS genes in tumor tissue is used to select patients with metastatic melanoma for targeted therapy. Cell-free circulating DNA (cfDNA) represents an accessible, non-invasive surrogate sample that could provide a snapshot of the BRAF and NRAS genotype in these patients. We investigated the feasibility of the Idylla™ assay for detection of BRAF and NRAS mutations in cfDNA of 19 patients with metastatic melanoma at baseline and during the course of treatment. The cfDNA genotype obtained with Idylla was compared to the results obtained with matched-tumor tissue and to clinical outcome...
November 16, 2018: Oncotarget
Farid Arman, Marina Barsoum, Umut Selamet, Hania Shakeri, Olivia Wassef, Mira Mikhail, Anjay Rastogi, Ramy M Hanna
Circulating antineutrophil cytoplasmic antibodies (ANCAs) are the central pathogenic mechanism for a group of systemic and renal syndromes called the ANCA-associated vasculitis (AAV). The nomenclature has changed from eponymous labeling to granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis. These syndromes predominantly affect the pulmonary and renal systems. We also review the molecular pathology behind ANCAs and associated antigens and infections...
2018: International Journal of Nephrology and Renovascular Disease
Maria J Tavares, Ulrich Güldener, Marcos Esteves, Arlete Mendes-Faia, Ana Mendes-Ferreira, Nuno P Mira
This work describes, for the first time, the genome sequence of a Saccharomycodes ludwigii strain. Although usually seen as a wine spoilage yeast, S. ludwigii has been of interest for the production of fermented beverages because it harbors several interesting properties, including the production of beneficial aroma compounds.
November 2018: Microbiology resource announcements
Mira Katan, Steven A Lubitz
No abstract text is available yet for this article.
December 7, 2018: Neurology
Mohamed M Mira, Katarzyna Ciacka, Robert D Hill, Claudio Stasolla
Differentiation of tracheary elements (TEs) in vitro was affected by the expression level of the Arabidopsis thaliana Col-0 phytoglobins (Pgbs). Over-expression of Pgb1 or Pgb2 (35S:Pgb1 or 35S:Pgb2 lines) reduced the differentiation process while suppression of either Pgb (Pgb1-RNAi or pgb2 lines) enhanced the production of TEs. The inductive effect of Pgb suppression on TE differentiation was linked to the reduced expression of the transcription factor MYC2. Suppression of this gene, observed under conditions of high NO levels or low Pgb expression, was sufficient to promote TE differentiation, while its over-expression abolished the promotive effect of Pgb suppression on the differentiation process...
November 29, 2018: Plant Physiology and Biochemistry: PPB
Jang-Hee Oh, Min Kyeong Shin, Hanon Lee, Jiyeong Lim, Mira Choi, Soyun Cho, Jin Ho Chung
No abstract text is available yet for this article.
October 30, 2018: Journal of Dermatological Science
Sae Young Jae, Kanokwan Bunsawat, Setor K Kunutsor, Eun Sun Yoon, Hyun Jeong Kim, Mira Kang, Yoon-Ho Choi, Barry A Franklin
We examined the hypothesis that delayed heart rate recovery (HRR) after exercise testing, an estimate of decreased autonomic function, predicts the risk of cardiometabolic syndrome (MetS) and is associated with continuous MetS risk scores in healthy men. Participants were 2,740 men who underwent general health examinations and had no evidence of MetS, cardiovascular diseases, diabetes, and hypertension at baseline. Baseline HRR was calculated as the difference between peak heart rate attained during exercise testing and the heart rate at 1 (HRR 1) and 2 minutes (HRR 2) after test termination...
November 24, 2018: American Journal of Cardiology
Josiah D McCain, Monia E Werlang, Andras Khoor, Isabel Mira-Avendano
No abstract text is available yet for this article.
December 2018: Cleveland Clinic Journal of Medicine
Mira Jung, Michael Dodsworth, Thomas Thum
Myocardial infarction triggers infiltration of several types of immune cells that coordinate both innate and adaptive immune responses. These play a dual role in post-infarction cardiac remodeling by initiating and resolving inflammatory processes, which needs to occur in a timely and well-orchestrated way to ensure a reestablishment of normalized cardiac functions. Thus, therapeutic modulation of immune responses might have benefits for infarct patients. While such strategies have shown great potential in treating cancer, applications in the post-infarction context have been disappointing...
December 6, 2018: Basic Research in Cardiology
Ahmed Ashour, Yhiya Amen, Toshinori Nakagawa, Yasuharu Niwa, Amira Mira, Koichiro Ohnuki, Shinki Murakami, Mitsuko Imao, Kuniyoshi Shimizu
An aliphatic ester of hydroxysalicylic acid (6), reported for the first time from a natural source in addition to five known compounds were isolated from the fermented Carica papaya L. preparation, a commercialized functional food. The known compounds were identified as 5-hydroxymethylfurfuraldehyde (1), trans-caffeic acid (2), butyl 4-hydroxybenzoate (butylparaben) (3), lycopene (4), benzyl isothiocyanate (5). Compounds 1 and 3 were reported for the first time from Papaya fruits through this study. The new compound showed a moderate antioxidant activity and a potent hair growth stimulating activity in vitro...
December 4, 2018: Natural Product Research
Mark A Pianka, Alec T McIntosh, Sahaj D Patel, Pegah R Bakhshi, Mira Jung
Genetic imprinting is the process of epigenetic labelling or silencing of particular genes, based on the maternal or paternal origin of the gene, in a heritable pattern. The incidence of imprinting disorders has become a growing concern due to the potential association between these congenital syndromes and assisted reproductive technologies (ARTs). This review presents a general summary of the imprinting process as well as the current knowledge surrounding the genetic and epigenetic underpinnings of the most prevalent imprinting disorders: Beckwith-Wiedemann syndrome (BWS), Silver-Russell syndrome (SRS), Prader-Willi syndrome (PWS), and Angelman syndrome (AS)...
2018: American Journal of Stem Cells
Fatima Ghaddar, Pascale Salameh, Nadine Saleh, Firas Farhat, Ramez Chahine, Nathalie Lahoud, Mira Hleyhel, Rouba K Zeidan
Background: Noncommunicable diseases are the leading cause of death in Lebanon, with cardiovascular diseases accounting for almost half of the annual deaths. Purpose: We aimed to determine awareness of noncardiac Lebanese hospitalized patients for their coronary artery disease risk factors, their level of adherence to medications or lifestyle modifications, and assess factors associated with awareness. Materials and methods: A cross-sectional study was conducted in 14 hospitals with a total of 382 patients...
2018: Vascular Health and Risk Management
Trong Dieu Hien Le, Mira Kattwinkel, Klaus Schützenmeister, John R Olson, Charles P Hawkins, Ralf B Schäfer
Salinization of surface waters is a global environmental issue that can pose a regional risk to freshwater organisms, potentially leading to high environmental and economic costs. Global environmental change including climate and land use change can increase the transport of ions into surface waters. We fit both multiple linear regression (LR) and random forest (RF) models on a large spatial dataset to predict Ca2+ (266 sites), Mg2+ (266 sites), and [Formula: see text] (357 sites) ion concentrations as well as electrical conductivity (EC-a proxy for total dissolved solids with 410 sites) in German running water bodies...
December 3, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Ceren Orhan, Eveline Van Looveren, Barbara Cagnie, Naziru Bashir Mukhtar, Dorine Lenoir, Mira Meeus
BACKGROUND: Chronic pain has been considered as a biopsychosocial condition in which cognitive and emotional factors as well as biological factors significantly affect perception of pain. Race, ethnicity and culture have a crucial impact on illness beliefs, health care preferences, help-seeking behaviors, and acceptance of medical interventions. OBJECTIVES: The aim of the present study was to systematically review the current evidence regarding the racial, ethnic and cultural alterations and differences in pain beliefs, cognitions, and behaviors in patients with chronic musculoskeletal pain (MSKP)...
November 2018: Pain Physician
Mira Holliday, Samantha Barratt Ross, Seakcheng Lim, Melissa Mangala, Adam Hill, Henrietta Cserne Szappanos, Livia Hool, Christopher Semsarian
Hypertrophic cardiomyopathy (HCM) is an inherited cardiomyopathy characterized by left ventricular hypertrophy ≥15 mm in the absence of loading conditions. HCM has a prevalence of up to one in 200, and can result in significant adverse outcomes including heart failure and sudden cardiac death. An induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells obtained from the whole blood of a 38-year-old female patient with HCM in which genetic testing identified the well-known pathogenic p...
November 28, 2018: Stem Cell Research
Mengru Mira Zhang, Don L Rempel, Michael L Gross
Fast Photochemical Oxidation of Protein (FPOP), based on a pulsed KrF laser (248nm) for free-radical generation, is a biophysical method that utilizes hydroxyl radicals to footprint proteins in solution. FPOP has been recognized for structural proteomics investigations, including epitope mapping, protein-aggregation characterization, protein-folding monitoring, and binding-affinity determination. The distinct merits of the platform are: i) the use of a scavenger to control radical lifetime and allow fast ("snapshot") footprinting of solvent-accessible residues in a protein; ii) the employment of a flow system to enable single-shot irradiation of small plugs of the targeted sample; iii) the use of methionine and catalase after radical oxidation chemistry to prevent post-oxidation with residual oxidizing species; and iv) the utilization of mature mass spectrometry-based proteomic methods to afford detailed analysis...
November 28, 2018: Free Radical Biology & Medicine
Saleh Daher, Namma Lev Cohen, Muhammad Massarwa, Mahmud Mahamid, Mira Nasser, Wadi Hazou, Rani Oren, Rifaat Safadi, Tawfik Khoury
BACKGROUND AND AIM: The progression of non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH) is believed to be the driver for future development of fibrosis and cirrhosis. Nevertheless, there remains a clear deficit in non-invasive methods for the diagnosis of NASH. The aim of the present study was to evaluate the prevalence of portal lymphadenopathy (PL) in biopsy- proven NAFLD patients and to determine whether PL correlates with NAFLD stage and severity. METHODS: A retrospective study included biopsy-proven NAFLD patients with up to date (within one year) abdominal imaging by computed tomography (CT) and/or magnetic resonance imaging (MRI)...
2018: PloS One
R Salido-Vallejo, M González-Velasco, M Guilabert, E I García, J J Mira
OBJECTIVE: To analyse barriers limiting an integral approach in the care process of patients with actinic keratosis, and to validate a questionnaire of their perception in order to assess this approach. METHOD: A qualitative study (Focus Group) was conducted to assess the perception of the healthcare process of professionals (dermatologists, family doctors, nurses, pharmacists and managers), and patients. A validation study of a new tool was conducted, defining the scope and contents of a questionnaire of perceived quality...
November 26, 2018: Journal of healthcare quality research
Tyler J Loftus, Juan C Mira, Julie A Stortz, Tezcan Ozrazgat-Baslanti, Gabriella L Ghita, Zhongkai Wang, Babette A Brumback, Ricardo F Ungaro, Azra Bihorac, Christiaan Leeuwenburgh, Frederick A Moore, Lyle L Moldawer, Scott C Brakenridge, Philip A Efron, Alicia M Mohr
BACKGROUND: Associations among inflammatory cytokines, erythropoietin, and anemia in critically ill septic patients remain unclear. This study tested the hypothesis that elevated inflammatory cytokines and decreased erythropoietin would be associated with iron-restricted anemia while accounting for operative blood loss, phlebotomy blood loss, and red blood cell (RBC) transfusion volume. METHODS: Prospective observational cohort study of 42 critically ill septic patients...
November 27, 2018: Journal of Trauma and Acute Care Surgery
Xiaoran Roger Liu, Mengru Mira Zhang, Don L Rempel, Michael L Gross
We report a novel method named LITPOMS (ligand titration, fast photochemical oxidation of proteins and mass spectrometry) to characterize protein-ligand binding stoichiometry, binding sites, and site-specific binding constants. The system used to test the method is melittin-calmodulin, in which the peptide melittin binds to calcium-bound calmodulin. Global-level measurements reveal the binding stoichiometry of 1:1 whereas peptide-level data coupled with fitting reveal the binding sites and the site-specific binding affinity...
November 27, 2018: Journal of the American Society for Mass Spectrometry
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