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Tyrosol

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https://www.readbyqxmd.com/read/28427293/beneficial-effects-of-tyrosol-on-altered-glycoprotein-components-in-streptozotocin-induced-diabetic-rats
#1
Ramasamy Chandramohan, Settu Saravanan, Leelavinothan Pari
CONTEXT: Olive oil is the major source of tyrosol which is a natural phenolic antioxidant. Olive oil constitutes a major component of the Mediterranean diet that is linked to a reduced incidence of chronic diseases. OBJECTIVE: This study evaluates the effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Diabetes mellitus was induced in male Wistar rats by streptozotocin (40 mg/kg body weight)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28417085/hepatoprotective-standardized-etoh-water-extract-from-the-seeds-of-fraxinus-rhynchophylla-hance
#2
Sen Guo, Tiantian Guo, Ni Cheng, Qingchao Liu, Yunting Zhang, Lu Bai, Li Zhang, Wei Cao, Chi-Tang Ho, Naisheng Bai
Fraxinus rhynchophylla Hance (Oleaceae), its stem barks are known as Cortex fraxini ( qín pí) listed in Chinese Pharmacopoeia. Phytochemical study has indicated that methanol extracts from Qinpi has protective effect on acute liver injury. The present study investigates the hepatoprotective activity of EtOH-water extract from the seeds of F. rhynchophylla Hance against carbon tetrachloride-induced liver injury in mice. The EtOH-water extract significantly alleviated liver damage as indicated by the decreased levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the malondialdehyde (MDA) content, and increased the levels of superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GSH-Px), and reduced the pathological tissue injury induced by CCl4...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28398744/natural-products-of-picea-endophytes-from-the-acadian-forest
#3
David R McMullin, Blake D Green, Natasha C Prince, Joey B Tanney, J David Miller
Endophytes of healthy needles were collected from Picea rubens (red spruce) and P. mariana (black spruce) in a survey of southeastern New Brunswick, Canada. Four endophyte strains were selected for further investigation based on the production of biologically active extracts from culture filtrates during screening as well as phylogenetic relationship to species known to produce natural products or taxonomic novelty. A novel endophyte within the family Rhytismataceae produced two new dihydropyrones (1 and 2) as major metabolites together with phthalides (3 and 4), isocoumarins (5 and 6), and tyrosol (7)...
April 11, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28381091/differential-off-line-lc-nmr-dolc-nmr-metabolomics-to-monitor-tyrosine-induced-metabolome-alterations-in-saccharomyces-cerevisiae
#4
Richard Hammerl, Oliver Frank, Thomas Hofmann
A novel differential off-line LC-NMR approach (DOLC-NMR) was developed to capture and quantify nutrient-induced metabolome alterations in Saccharomyces cerevisiae. Off-line coupling of HPLC separation and (1)H NMR spectroscopy supported by automated comparative bucket analyses, followed by quantitative (1)H NMR using ERETIC 2 (electronic reference to access in vivo concentrations), has been successfully used to quantitatively record changes in the metabolome of S. cerevisiae upon intervention with the aromatic amino acid l-tyrosine...
April 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28361236/efficient-synthesis-of-tyrosol-galactosides-by-the-%C3%AE-galactosidase-from-enterobacter-cloacae-b5
#5
Tingting Qi, Guofeng Gu, Li Xu, Min Xiao, Lili Lu
In this work, the β-galactosidase from Enterobacter cloacae B5 (BgaB5) exhibited excellent transglycosylation activity toward tyrosol (p-hydroxyphenethyl alcohol) when using lactose as the glycosyl donor, generating a series of tyrosol glycosides with potential pharmacological properties. The effects of substrate concentration, temperature, pH, and reaction time on the transglycosylation reaction catalyzed by the enzyme BgaB5 were studied in detail. Three tyrosol derivatives were produced in a total high yield of 50...
March 30, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28360012/assessment-of-olea-europaea-l-fruit-extracts-phytochemical-characterization-and-anticancer-pathway-investigation
#6
Amina Maalej, Zouhaier Bouallagui, Fatma Hadrich, Hiroko Isoda, Sami Sayadi
Olea europaea L. has been widely used as an advantageous rich source of bioactive compounds of high economic value leading to its use in pharmaceutical, cosmetic, and agriculture industries. Ethanolic extracts of olive fruits from three different cultivars (OFE) were studied for their phytochemical contents and were investigated for antioxidant activities and anticancer potential. Major polyphenols detected in these extracts were tyrosol, hydroxytyrosol, oleuropein, rutin, quercetin and glucoside forms of luteolin and apigenin...
March 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28352078/mining-of-efficient-microbial-udp-glycosyltransferases-by-motif-evolution-cross-plant-kingdom-for-application-in-biosynthesis-of-salidroside
#7
Bo Fan, Tianyi Chen, Sen Zhang, Bin Wu, Bingfang He
The plant kingdom provides a large resource of natural products and various related enzymes are analyzed. The high catalytic activity and easy genetically modification of microbial enzymes would be beneficial for synthesis of natural products. But the identification of functional genes of target enzymes is time consuming and hampered by many contingencies. The potential to mine microbe-derived glycosyltransferases (GTs) cross the plant kingdom was assessed based on alignment and evolution of the full sequences and key motifs of target enzymes, such as Rhodiola-derived UDP-glycosyltransferase (UGT73B6) using in salidroside synthesis...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28322962/understanding-the-link-between-antimicrobial-properties-of-dietary-olive-phenolics-and-bacterial-atp-synthase
#8
Amon Amini, Mason Liu, Zulfiqar Ahmad
The naturally occurring olive phenolics tyrosol, hydroxytyrosol, dihydroxyphenylglycol (DHPG), and oleuropein are known to have antioxidant, antitumor, and antibacterial properties. In the current study, we examined whether the antimicrobial properties of tyrosol, hydroxytyrosol, DHPG, and oleuropein were linked to the inhibition of bacterial ATP synthase. Tyrosol, hydroxytyrosol, DHPG, and oleuropein inhibited Escherichia coli wild-type and mutant membrane-bound F1Fo ATP synthase to variable degrees. The growth properties of wild-type, null, and mutant strains in presence of above olive phenolics were also abrogated to variable degrees on limiting glucose and succinate...
March 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28321957/activity-of-exogenous-tyrosol-in-combination-with-caspofungin-and-micafungin-against-candida-parapsilosis-sessile-cells
#9
Renátó Kovács, Zoltán Tóth, Fruzsina Nagy, Lajos Daróczi, Aliz Bozó, László Majoros
AIMS: Fungal quorum sensing molecules may have an inhibitory effect as adjuvant against Candida biofilms. Therefore, in vitro activity of caspofungin and micafungin was evaluated against Candida parapsilosis biofilms in the presence of tyrosol. METHODS AND RESULTS: Interactions were assessed using fractional inhibitory concentration index (FICI) determination, metabolic activity-based time-kill experiments, and scanning electron microscopy. Tyrosol caused 1- to 16-fold and 2- to 32-fold decrease in median caspofungin and micafungin MICs, respectively...
March 21, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28317728/direct-study-of-minor-extra-virgin-olive-oil-components-without-any-sample-modification-1-h-nmr-multisupression-experiment-a-powerful-tool
#10
Ainhoa Ruiz-Aracama, Encarnación Goicoechea, María D Guillén
Proton Nuclear Magnetic Resonance ((1)H NMR) was employed to study monovarietal commercial Spanish extra-virgin olive oils (EVOO) (Arbequina, Arroniz, Cornicabra, Hojiblanca and Picual). Each sample was analyzed by a standard pulse and by an experiment suppressing the main lipid signals, enabling the detection of signals of minor components. The aim was to determine the possibilities of both (1)H NMR approaches to characterize EVOO composition, focusing on acyl groups, squalene, sterols, triterpene acids/esters, fatty alcohols, wax esters and phenols (lignans, tyrosol, hydroxytyrosol, oleocanthal, oleacein, oleokoronal, oleomissional, ligstrodials and oleuropeindials), and to determine hydrolysis and oxidation levels...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28284180/candida-krusei-form-mycelia-along-agar-surfaces-towards-each-other-and-other-candida-species
#11
Jacob Fleischmann, Corey D Broeckling, Sarah Lyons
BACKGROUND: Candida krusei has been known to exhibit communal interactions such as pellicle formation and crawling out of nutritional broth. We noticed another possible interaction on agar surfaces, where C. krusei yeast cells formed mycelia along agar surfaces toward each other. We report here the results of experiments to study this interaction. RESULTS: When C.krusei yeast cells are plated in parallel streaks, they form mycelia along agar surfaces toward other yeasts...
March 11, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28276907/dietary-sources-of-polyphenols-in-the-mediterranean-healthy-eating-aging-and-lifestyle-meal-study-cohort
#12
Justyna Godos, Stefano Marventano, Antonio Mistretta, Fabio Galvano, Giuseppe Grosso
The aim of this study was to estimate the dietary intake and major food sources of polyphenols in the Mediterranean healthy Eating, Aging and Lifestyles (MEAL) study cohort. A total of 1937 individuals (18 + y) of urban population of Catania, Italy, completed a validated 110-item food frequency questionnaire; Phenol-Explorer database was used to estimate polyphenol intake. Mean intake of polyphenols was 663.7 mg/d; the most abundant classes were phenolic acids (362.7 mg/d) and flavonoids (258.7 mg/d)...
February 9, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28190857/protective-effects-of-tyrosol-against-lps-induced-acute-lung-injury-via-inhibiting-nf-%C3%AE%C2%BAb-and-ap-1-activation-and-activating-the-ho-1-nrf2-pathways
#13
Wen-Chen Wang, Yan-Min Xia, Bo Yang, Xiang-Ni Su, Jia-Kuan Chen, Wei Li, Tao Jiang
Tyrosol (Tyr) is a natural antioxidant that displays anti-oxidant and anti-inflammatory properties. The present study aimed to investigate the effect and mechanism of Tyr on lipopolysaccharide (LPS)-induced acute lung injury (ALI). In a mouse model, we found that pretreatment with Tyr significantly improved survival rate, attenuated lung permeability, ameliorated histopathological alterations, reduced expression of the inflammatory mediators and improved expression of the antioxidant enzyme. Further study revealed that Tyr markedly inhibited nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) activation at both in vivo and in vitro levels...
February 10, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28170343/bioenergetic-strategy-of-microalgae-for-the-biodegradation-of-tyrosol-and-hydroxytyrosol
#14
Aikaterini Papazi, Andreas Ioannou, Myrto Symeonidi, Andreas G Doulis, Kiriakos Kotzabasis
Olive mill wastewater has significant polluting properties due to its high phenolic content [mainly tyrosol (trs) and hydroxytyrosol (htrs)]. Growth kinetics and a series of fluorescence induction measurements for Scenedesmus obliquus cultures showed that microalgae can be tolerant of these phenolic compounds. Changes in the cellular energy reserves and concentration of the phenolic compounds adjust the "toxicity" of these compounds to the microalgae and are, therefore, the main parameters that affect biodegradation...
February 7, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28142218/differential-effects-of-the-combination-of-tyrosol-with-chlorhexidine-gluconate-on-oral-biofilms
#15
L R do Vale, Acb Delbem, L S Arias, R A Fernandes, Apm Vieira, D B Barbosa, D R Monteiro
OBJECTIVE: This study assessed the effect of tyrosol and chlorhexidine gluconate in combination against Candida albicans, Candida glabrata, and Streptococcus mutans in the planktonic state or forming biofilms in vitro. MATERIALS AND METHODS: Checkerboard assays were performed for determination of minimum inhibitory concentration. Biofilms were cultivated during 24 h on specimens of acrylic resin and hydroxyapatite and treated with the drugs alone or in combination twice a day for 1 min, during 3 days...
January 31, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28110532/phytotoxic-lipophilic-metabolites-produced-by-grapevine-strains-of-lasiodiplodia-species-in-brazil
#16
Alessio Cimmino, Tamara Cinelli, Marco Masi, Pierluigi Reveglia, Marcondes Araujo da Silva, Laura Mugnai, Sami J Michereff, Giuseppe Surico, Antonio Evidente
Phytotoxic metabolites produced in liquid culture by six species of Lasiodiplodia isolated in Brazil and causing Botryosphaeria dieback of grapevine were chemically identified. As ascertained by LC/MS, L. brasiliense, L. crassispora, L. jatrophicola, and L. pseudotheobromae produced jasmonic acid, and L. brasiliense synthesized, besides jasmonic acid, also (3R,4S)-4-hydroxymellein. L. euphorbicola and L. hormozganensis produced some low molecular weight lipophilic toxins. Specifically, L. euphorbicola produced (-)-mellein, (3R,4R)-(-)- and (3R,4S)-(-)-4-hydroxymellein, and tyrosol, and L...
January 31, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28081284/analysis-of-the-relationship-between-ribosomal-dna-its-sequences-and-active-components-in-rhodiola-plants
#17
D J Zhang, W T Yuan, M T Li, Y H Zhang
Rhodiola plants are a valuable resource in traditional Chinese medicine. The objective of this study was to evaluate the correlation between ribosomal DNA internal transcribed spacer (ITS) sequences and the three active components in Rhodiola plants. For this, we determined ITS sequence polymorphisms and the concentrations of active components salidroside, tyrosol, and gallic acid in different Rhodiola species from the Tibetan Plateau. In a total of 23 Rhodiola samples, 16 different haplotypes were defined based on their ITS sequences...
December 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28073099/golden-root-a-wholesome-treat-of-immunity
#18
REVIEW
Kunjan Khanna, K P Mishra, Lilly Ganju, Shashi Bala Singh
Rhodiola is native to the high altitude regions of Asia, Europe and Northern Hemisphere. It has a long history of use as a medicinal plant in various ailments, boosting immunity, increasing energy and mental capacity. It is also known as "Adaptogen" to help the body to adapt and resist stress. The part of the plant, which is used for medicinal values, is rhizome, which is an underground stem. The rhizome contains mainly salidroside, rosin, rosavin and p-tyrosol. There are many studies, which have reported the effects of Rhodiola spp...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28068598/novel-flavonolignan-hybrid-antioxidants-from-enzymatic-preparation-to-molecular-rationalization
#19
Eva Vavříková, Vladimír Křen, Lubica Jezova-Kalachova, Michal Biler, Benjamin Chantemargue, Michaela Pyszková, Sergio Riva, Marek Kuzma, Kateřina Valentová, Jitka Ulrichová, Jiří Vrba, Patrick Trouillas, Jan Vacek
A series of antioxidants was designed and synthesized based on conjugation of the hepatoprotective flavonolignan silybin with l-ascorbic acid, trolox alcohol or tyrosol via a C12 aliphatic linker. These hybrid molecules were prepared from 12-vinyl dodecanedioate-23-O-silybin using the enzymatic regioselective acylation procedure with Novozym 435 (lipase B) or with lipase PS. Voltammetric analyses showed that the silybin-ascorbic acid conjugate exhibited excellent electron donating ability, in comparison to the other conjugates...
February 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28063518/role-of-nutraceutical-sirt1-modulators-in-ampk-and-mtor-pathway-evidence-of-a-synergistic-effect
#20
Luca Giovannini, Sara Bianchi
OBJECTIVE: The aim of this study was to evaluate the effect of different natural substances on SIRT1 expression and on AMPK and mTOR phosphorylation. Moreover, we investigated the presence of a synergistic effect between the substances. METHODS: Human cervical carcinoma cells were seeded in 12-well plates, then incubated with the nine tested substances (resveratrol, quercetin, berberine, catechin, tyrosol, ferulic acid, niclosamide, curcumin, and malvidin) at different concentrations and left in incubation for 3, 6, and 24 h...
February 2017: Nutrition
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