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https://www.readbyqxmd.com/read/28081284/analysis-of-the-relationship-between-ribosomal-dna-its-sequences-and-active-components-in-rhodiola-plants
#1
D J Zhang, W T Yuan, M T Li, Y H Zhang
Rhodiola plants are a valuable resource in traditional Chinese medicine. The objective of this study was to evaluate the correlation between ribosomal DNA internal transcribed spacer (ITS) sequences and the three active components in Rhodiola plants. For this, we determined ITS sequence polymorphisms and the concentrations of active components salidroside, tyrosol, and gallic acid in different Rhodiola species from the Tibetan Plateau. In a total of 23 Rhodiola samples, 16 different haplotypes were defined based on their ITS sequences...
December 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28073099/golden-root-a-wholesome-treat-of-immunity
#2
REVIEW
Kunjan Khanna, K P Mishra, Lilly Ganju, Shashi Bala Singh
Rhodiola is native to the high altitude regions of Asia, Europe and Northern Hemisphere. It has a long history of use as a medicinal plant in various ailments, boosting immunity, increasing energy and mental capacity. It is also known as "Adaptogen" to help the body to adapt and resist stress. The part of the plant, which is used for medicinal values, is rhizome, which is an underground stem. The rhizome contains mainly salidroside, rosin, rosavin and p-tyrosol. There are many studies, which have reported the effects of Rhodiola spp...
January 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28068598/novel-flavonolignan-hybrid-antioxidants-from-enzymatic-preparation-to-molecular-rationalization
#3
Eva Vavříková, Vladimír Křen, Lubica Jezova-Kalachova, Michal Biler, Benjamin Chantemargue, Michaela Pyszková, Sergio Riva, Marek Kuzma, Kateřina Valentová, Jitka Ulrichová, Jiří Vrba, Patrick Trouillas, Jan Vacek
A series of antioxidants was designed and synthesized based on conjugation of the hepatoprotective flavonolignan silybin with l-ascorbic acid, trolox alcohol or tyrosol via a C12 aliphatic linker. These hybrid molecules were prepared from 12-vinyl dodecanedioate-23-O-silybin using the enzymatic regioselective acylation procedure with Novozym 435 (lipase B) or with lipase PS. Voltammetric analyses showed that the silybin-ascorbic acid conjugate exhibited excellent electron donating ability, in comparison to the other conjugates...
December 26, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28063518/role-of-nutraceutical-sirt1-modulators-in-ampk-and-mtor-pathway-evidence-of-a-synergistic-effect
#4
Luca Giovannini, Sara Bianchi
OBJECTIVE: The aim of this study was to evaluate the effect of different natural substances on SIRT1 expression and on AMPK and mTOR phosphorylation. Moreover, we investigated the presence of a synergistic effect between the substances. METHODS: Human cervical carcinoma cells were seeded in 12-well plates, then incubated with the nine tested substances (resveratrol, quercetin, berberine, catechin, tyrosol, ferulic acid, niclosamide, curcumin, and malvidin) at different concentrations and left in incubation for 3, 6, and 24 h...
February 2017: Nutrition
https://www.readbyqxmd.com/read/28024731/olive-oil-polyphenols-a-quantitative-method-by-high-performance-liquid-chromatography-diode-array-detection-for-their-determination-and-the-assessment-of-the-related-health-claim
#5
Massimo Ricciutelli, Shara Marconi, Maria Chiara Boarelli, Giovanni Caprioli, Gianni Sagratini, Roberto Ballini, Dennis Fiorini
In order to assess if an extra virgin olive oil (EVOO) can be acknowledged with the health claim related to olive oil polyphenols (Reg. EU n.432/2012), a new method to quantify these species in EVOO, by means of liquid-liquid extraction followed by HPLC-DAD/MS/MS of the hydroalcoholic extract, has been developed and validated. Different extraction procedures, different types of reverse-phase analytical columns (Synergi Polar, Spherisorb ODS2 and Kinetex) and eluents have been tested. The chromatographic column Synergi Polar (250×4...
December 11, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27986474/phosphatidyl-hydroxytyrosol-and-phosphatidyl-tyrosol-bilayer-properties
#6
Kervin O Evans, David L Compton
Hydroxytyrosol and tyrosol phospholipids were enzymatically synthesized and investigated for their bilayer properties. Dynamic light scattering demonstrated that hand extrusion at 100nm consistently resulted in liposomes of nearly 85nm diameter for both phosphatidyl-hydroxytyrosol (DOPHT) and phosphatidyl-tyrosol (DOPT). Transmission electron microscopy showed DOPT and DOPHT liposomes extruded at 100-nm to be spherical and non-distinctive from one another. Zeta potential measurements resulted in surface charges<-25mV, demonstrating both DOPT and DOPHT form highly stable liposomes...
December 14, 2016: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/27976895/angiogenesis-inhibitors-and-anti-inflammatory-agents-from-phoma-sp-ntou4195
#7
Ming-Shian Lee, Shih-Wei Wang, Guei-Jane Wang, Ka-Lai Pang, Ching-Kuo Lee, Yueh-Hsiung Kuo, Hyo-Jung Cha, Ruo-Kai Lin, Tzong-Huei Lee
Seven new polyketides, phomaketides A-E (1-5) and pseurotins A3 (6) and G (7), along with the known compounds FR-111142, pseurotins A, A1, A2, D, and F2, 14-norpseurotin A, α-carbonylcarbene, tyrosol, cyclo(-l-Pro-l-Leu), and cyclo(-l-Pro-l-Phe), were purified from the fermentation broth and mycelium of the endophytic fungal strain Phoma sp. NTOU4195 isolated from the marine red alga Pterocladiella capillacea. The structures were established through interpretation of spectroscopic data. The antiangiogenic and anti-inflammatory effects of 1-7 and related analogues were evaluated using human endothelial progenitor cells (EPCs) and lipopolysaccharide (LPS)-activated murine macrophage RAW264...
December 23, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27934453/total-synthesis-of-clerobungin-a-via-a-cascade-cyclization-reaction
#8
James Mease, Keith P Reber
The first total synthesis of the novel cyclohexylethanoid natural product clerobungin A has been achieved in six steps and 14% overall yield starting from commercially available tyrosol. Key steps in this sequence include a bioinspired oxidative dearomatization of a phenol and a hemiacetalization/oxa-Michael cascade to form the tricyclic ring system. Resolution of a late-stage intermediate via chiral HPLC allowed for the measurement of the chiroptical properties of both enantiomers of clerobungin A, supporting the scalemic nature of the natural product...
December 2, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27931126/%C3%AE-tocopherol-%C3%AE-carotene-lutein-squalene-and-secoiridoids-in-seven-monocultivar-italian-extra-virgin-olive-oils
#9
Roberto Ambra, Fausta Natella, Sabrina Lucchetti, Valentina Forte, Gianni Pastore
Fatty acids and bioactive lipophilic and hydrophilic compounds (tocopherols, β-carotene, lutein, squalene, total polyphenols and secoiridoids) in monocultivar Italian extra-virgin olive oil (EVOO) samples produced from the Leccino cultivar and six other yet uncharacterised cultivars (Rustica, Carpinetana, Dritta, Gentile di Chieti and Intosso) were analysed, also taking into account the effect of the type of decanter used for the oil extraction. Significant differences among cultivars were found for α-tocopherol and squalene, but not for carotenoids...
December 8, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27916128/a-paper-based-platform-with-a-pencil-drawn-dual-amperometric-detector-for-the-rapid-quantification-of-ortho-diphenols-in-extravirgin-olive-oil
#10
Nicolò Dossi, Rosanna Toniolo, Flavia Impellizzieri, Franco Tubaro, Gino Bontempelli, Fabio Terzi, Evandro Piccin
A simple, sensitive and fast responding device is described for the discrimination of hydrophilic ortho-diphenols, whose presence in abundant enough amounts is typical for extra virgin olive oils (EVOOs), from hydrophilic mono-phenols instead present in almost all vegetable oils. It consists of a dual electrode detector pencil-drawn at the end of a paper microfluidic channel, defined by hydrophobic barriers, where samples of these antioxidants, extracted from vegetable oils by a 80:20% v/v acetonitrile/water mixture, were applied...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27913892/early-harvest-effects-on-hydrophilic-phenolic-components-of-extra-virgin-olive-oils-cvs-ayval%C3%A4-k-memecik-and-topaka%C3%A5-%C3%A4
#11
Fatma Yıldırım, Adnan Nurhan Yıldırım, Gülcan Özkan, Bekir Şan, Mehmet Polat, Hatice Aşık, Yaşar Karakurt, Sezai Ercişli
The study was conducted to determine the effects of cultivar, harvest period, and their interaction on the hydrophilic phenolic components extra virgin olive oils of the cultivars 'Ayvalık,' 'Memecik,' and 'Topakaşı.' Olives were collected at three different harvesting periods: (1) early harvest period-1 (Beginning of spotting), (2) early harvest period-2 (End of spotting), and (3) optimum harvest period. Oils were extracted using the Abencor system. HPLC (High-performance liquid chromatograph) technique was used to quantify the phenolic compounds including tyrosol (p-HPEA), hydroxytyrosol (3,4-DHPEA), luteolin, rutin, quercetin, catechin, sinapinic acid, p-coumaric acid, cinnamic acid, vanillin, vanillic acid, ferulic acid, and gallic acid...
December 2, 2016: Biochemical Genetics
https://www.readbyqxmd.com/read/27907867/adsorption-characteristics-of-adsorbent-resins-and-antioxidant-capacity-for-enrichment-of-phenolics-from-two-phase-olive-waste
#12
Zhihong Wang, Chengzhang Wang, Jiaojiao Yuan, Changwei Zhang
In this study, the adsorption properties of nine resins including polyamide resin (30-60), polyamide resin (60-100) AB-8, S-8, D-101, NKA-9, NKA-II, XDA-1 and XDA-4 for enrichment phenolics of the olive waste were investigated. XDA-1 and NKA-II were chosen for further study due to their outstanding adsorption and desorption capacity. XDA-1 and NKA-II had similar adsorption and desorption behaviors for phenolics of olive waste. The adsorption mechanism could be better explained by pseudo second-order kinetics model and Freundlich isotherm model, and the adsorption processes were spontaneously and exothermic...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27810738/hydroxytyrosol-inhibits-hydrogen-peroxide-induced-apoptotic-signaling-via-labile-iron-chelation
#13
Natalia Kitsati, Michalis D Mantzaris, Dimitrios Galaris
Although it is known that Mediterranean diet plays an important role in maintaining human health, the underlying molecular mechanisms remain largely unknown. The aim of this investigation was to elucidate the potential role of ortho-dihydroxy group containing natural compounds in H2O2-induced DNA damage and apoptosis. For this purpose, the main phenolic alcohols of olive oil, namely hydroxytyrosol and tyrosol, were examined for their ability to protect cultured cells under conditions of oxidative stress. A strong correlation was observed between the ability of hydroxytyrosol to mitigate intracellular labile iron level and the protection offered against H2O2-induced DNA damage and apoptosis...
October 15, 2016: Redox Biology
https://www.readbyqxmd.com/read/27803730/quick-assessment-of-the-economic-value-of-olive-mill-waste-water
#14
Riccardo Delisi, Filippo Saiano, Mario Pagliaro, Rosaria Ciriminna
BACKGROUND: Olive biophenols are emerging as a valued class of natural products finding practical application in the food, pharmaceutical, beverage, cosmetic and nutraceutical industries due to their powerful biological activity which includes antioxidant and antimicrobial properties. Olive mill waste water (OMWW), a by-product in olive oil manufacturing, is rich in biophenols such as hydroxytyrosol and tyrosol. The amount of biophenols depends on the cultivar, the geographical area of cultivation, and the seasonal conditions...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27792767/association-between-polyphenol-intake-and-hypertension-in-adults-and-older-adults-a-population-based-study-in-brazil
#15
Andreia Machado Miranda, Josiane Steluti, Regina Mara Fisberg, Dirce Maria Marchioni
BACKGROUND/OBJECTIVE: Hypertension is an important risk factor for cardiovascular disease, and diet has been identified as a modifiable factor for preventing and controlling hypertension. Besides, epidemiological studies have suggested an inverse association between polyphenol intake and cardiovascular diseases. The aim of this study was to evaluate the association between the intake of polyphenols and hypertension in a general population of Sao Paulo. METHODS: Data came from the 'Health Survey of Sao Paulo (ISA-Capital)' among 550 adults and older adults in Sao Paulo, Brazil...
2016: PloS One
https://www.readbyqxmd.com/read/27792334/phenolic-compounds-and-sesquiterpene-lactones-profile-in-leaves-of-nineteen-artichoke-cultivars
#16
Youssef Rouphael, Jamila Bernardi, Mariateresa Cardarelli, Letizia Bernardo, David Kane, Giuseppe Colla, Luigi Lucini
Leaves of globe artichoke are food industry byproducts gaining interest due to their therapeutic and nutraceutical potential. The total phenolics, flavonoids, and flavonols content as well as radical scavenging capacity and reducing antioxidant power were determined in leaves of 19 artichoke cultivars. An untargeted analysis based on high-resolution mass spectrometry was then carried out to profile phenolic compounds and sesquiterpene lactones (STLs). The phenolic profile of leaf extracts from different cultivars was widely diverse and included flavonoids, hydroxycinnamic acids, tyrosols, and lignans...
November 16, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27790915/exploring-the-colonic-metabolism-of-grape-and-strawberry-anthocyanins-and-their-in-vitro-apoptotic-effects-in-ht-29-colon-cancer-cells
#17
Maria-Carmen López de Las Hazas, Juana I Mosele, Alba Macià, Iziar A Ludwig, Maria-Jose' Motilva
Beneficial properties attributed to the intake of fruit and red wine have been associated with the presence of significant amounts of anthocyanins. However, their low absorption and consequent accumulation in the gut have generated the suspicion that colonic metabolites of anthocyanins are probably involved in their protective effects. Grape pomace and strawberries extracts, rich in malvidin- and pelargonidin-glucoside, respectively, were fermented in-vitro using human feces as microbial inoculum. After 8 h of anaerobic incubation, the anthocyanins were almost completely degraded while their microbial metabolites concentration was highest at 24 h...
October 28, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27713969/effect-of-bactrocera-oleae-on-phenolic-compounds-and-antioxidant-and-antibacterial-activities-of-two-algerian-olive-cultivars
#18
Lynda Medjkouh, Abderezak Tamendjari, Rita C Alves, Mariana Araújo, M Beatriz P P Oliveira
Bactrocera oleae, an olive fruit fly, is a major olive pest in Algeria. In this study, olives of two Algerian cultivars (Limli and Rougette de Métidja) with different degrees of infestation by the Bactrocera oleae fly (0%, not attacked; 100%, all attacked; and real %) were analysed. The influence of this pest on individual phenolic compounds (HPLC-DAD-FLD) and antioxidant profiles was ascertained. The antibacterial activity against 8 human enteropathogenic bacteria was also assessed. The results show that Rougette de Métidja, the cultivar with higher drupe size, was attacked to a greater degree than Limli, and the B...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27713961/anti-cancer-properties-of-olive-oil-secoiridoid-phenols-a-systematic-review-of-in-vivo-studies
#19
REVIEW
R Fabiani
Epidemiological studies suggest that olive oil intake is associated to a reduced risk of cancer. Recently, the chemopreventive activity of olive oil has been attributed to its unique phenolic compounds represented by phenolic alcohols, hydroxytyrosol (3,4-dihydroxyphenylethanol: 3,4-DHPEA) and tyrosol (p-hydroxyphenylethanol: p-HPEA), and their secoiridoid derivatives 3,4-DHPEA-EA (oleuropein aglycon), p-HPEA-EA (ligstroside aglycon), 3,4-DHPEA-EDA, p-HPEA-EDA (oleocanthal), and oleuropein. Several studies have demonstrated that these compounds are able to inhibit proliferation and induce apoptosis in different tumor cell lines...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27664690/cyp2d6-and-cyp2a6-biotransform-dietary-tyrosol-into-hydroxytyrosol
#20
Jose Rodríguez-Morató, Patricia Robledo, Julie-Anne Tanner, Anna Boronat, Clara Pérez-Mañá, C-Y Oliver Chen, Rachel F Tyndale, Rafael de la Torre
The dietary phenol tyrosol has been reported to be endogenously transformed into hydroxytyrosol, a potent antioxidant with multiple health benefits. In this work, we evaluated whether tyrosine hydroxylase (TH) and cytochrome P450s (CYPs) catalyzed this process. To assess TH involvement, Wistar rats were treated with α-methyl-L-tyrosine and tyrosol. Tyrosol was converted into hydroxytyrosol whilst α-methyl-L-tyrosine did not inhibit the biotransformation. The role of CYP was assessed in human liver microsomes (HLM) and tyrosol-to-hydroxytyrosol conversion was observed...
February 15, 2017: Food Chemistry
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