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Tyrosol

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https://www.readbyqxmd.com/read/28622460/antifungal-activity-of-tyrosol-and-farnesol-used-in-combination-against-candida-species-in-the-planktonic-state-or-forming-biofilms
#1
Douglas Roberto Monteiro, Laís Salomão Arias, Renan Aparecido Fernandes, Lucas Fernando Deszo da Silva, Manoel Olavo Valentim Fernandes de Castilho, Thaís Oliveira da Rosa, Ana Paula Miranda Vieira, Fabiana Gouveia Straioto, Débora Barros Barbosa, Alberto Carlos Botazzo Delbem
AIM: This study examined the antifungal activity of the combination of tyrosol and farnesol against Candida albicans and Candida glabrata in the planktonic state or forming biofilms. METHODS AND RESULTS: The effect of drug association against Candida planktonic cells was assessed by the fractional inhibitory concentration index. Mono and dual-species biofilms were developed (24 h) and the compounds, applied during 3 days, with 2 daily treatments of 1 minute each...
June 16, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28597159/metabolite-analysis-of-endophytic-fungi-from-cultivars-of-zingiber-officinale-rosc-identifies-myriad-of-bioactive-compounds-including-tyrosol
#2
C Anisha, E K Radhakrishnan
Endophytic fungi associated with rhizomes of four cultivars of Zingiber officinale were identified by molecular and morphological methods and evaluated for their activity against soft rot pathogen Pythium myriotylum and clinical pathogens. The volatile bioactive metabolites produced by these isolates were identified by GC-MS analysis of the fungal crude extracts. Understanding of the metabolites produced by endophytes is also important in the context of raw consumption of ginger as medicine and spice. A total of fifteen isolates were identified from the four varieties studied...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28578068/phenolic-profile-and-fermentation-patterns-of-different-commercial-gluten-free-pasta-during-in-vitro-large-intestine-fermentation
#3
Gabriele Rocchetti, Luigi Lucini, Giulia Chiodelli, Gianluca Giuberti, Antonio Gallo, Francesco Masoero, Marco Trevisan
The fate of phenolic compounds, along with short-chain fatty acids (SCFAs) production kinetics, was evaluated on six different commercial gluten-free (GF) pasta samples varying in ingredient compositions, focussing on the in vitro faecal fermentation after the gastrointestinal digestion. A general reduction of both total phenolics and reducing power was observed in all samples, together with a substantial change in phenolic profile over 24h of faecal fermentation, with differences among GF pasta samples. Flavonoids, hydroxycinnamics and lignans degraded over time, with a concurrent increase in low-molecular-weight phenolic acids (hydroxybenzoic acids), alkylphenols, hydroxybenzoketones and tyrosols...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28571537/synthesis-and-biological-evaluation-of-new-tyrosol-salicylate-derivatives-as-potential-anti-inflammatory-agents
#4
Rafael P Aguiar, Fahad S Aldawsari, Luiz A M Wiirzler, Saulo E Silva-Filho, Francielli M S Silva-Comar, Ciomar A Bersani-Amado, Carlos A Velázquez-Martínez, Roberto K N Cuman
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used medications in inflammatory illnesses. However, the gastrointestinal bleeding and toxicity associated with NSAIDs long term use prompted the quest towards investigations for new anti-inflammatory agents. Natural and natural-derived molecules proved its anti-inflammatory efficacy in vitro as well as in vivo. Given this background, the scope of this research involves structural changes of the natural polyphenol (tyrosol) generating two new salicylate derivatives and testing their biological properties , focusing in anti-inflammatory effects assessed in vitro and in vivo assays...
June 1, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28566694/production-of-three-phenylethanoids-tyrosol-hydroxytyrosol-and-salidroside-using-plant-genes-expressing-in-escherichia-coli
#5
Daeun Chung, So Yeon Kim, Joong-Hoon Ahn
Polyphenols, which include phenolic acids, flavonoids, stilbenes, and phenylethanoids, are generally known as useful antioxidants. Tyrosol, hydroxytyrosol, and salidroside are typical phenylethanoids. Phenylethanoids are found in plants such as olive, green tea, and Rhodiola and have various biological activities, including the prevention of cardiovascular diseases, cancer, and brain damage. We used Escherichia coli to synthesize three phenylethanoids, tyrosol, hydroxytyrosol, and salidroside. To synthesize tyrosol, the aromatic aldehyde synthase (AAS) was expressed in E...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28540726/sorption-and-release-of-natural-phenolic-antioxidants-in-different-cyclodextrin-polymers
#6
M García-Padial, M C Martínez-Ohárriz, J R Isasi, A Zornoza
The sorption and release of tyrosol and caffeic acid, two biophenolic antioxidants with known health benefits, in different insoluble cyclodextrin polymers have been studied. Cyclodextrin polymers were synthesized by cross-linking β-cyclodextrin or 50:50 w/w nominal mixtures of α- and β-cyclodextrins using either epichlorohydrin (EP) or toluene-2,4-diisocyanate (TDI) as cross-linking agents. An analogous sucrose polymer was prepared using EP as cross-linking reagent. Freundlich isotherms and isosteric heats of sorption for tyrosol and caffeic acid in the insoluble β-cyclodextrin polymer cross-linked with epichlorohydrin at 50 °C were obtained and discussed...
June 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28540463/investigating-the-organic-and-conventional-production-type-of-olive-oil-with-target-and-suspect-screening-by-lc-qtof-ms-a-novel-semi-quantification-method-using-chemical-similarity-and-advanced-chemometrics
#7
Natasa P Kalogiouri, Reza Aalizadeh, Nikolaos S Thomaidis
The discrimination of organic and conventional production has been a critical topic of public discussion and constitutes a scientific issue. It remains a challenge to establish a correlation between the agronomical practices and their effects on the composition of olive oils, especially the phenolic composition, since it defines their organoleptic and nutritional value. Thus, a liquid chromatography-electrospray ionization-quadrupole time of flight tandem mass spectrometric method was developed, using target and suspect screening workflows, coupled with advanced chemometrics for the identification of phenolic compounds and the discrimination between organic and conventional extra virgin olive oils...
May 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28530096/engineering-eschericha-coli-for-enhanced-tyrosol-production
#8
Yuxiang Xue, Xianzhong Chen, Cui Yang, Junzhuang Chang, Wei Shen, You Fan
Tyrosol is a phenolic compound found in olive oil and wines. The health benefits of tyrosol have attracted considerable attention. Because the tyrosol extraction from plants poses a major obstacle, biosynthesizing this compound using microbial hosts is of interest. In this study, the phenylpyruvate decarboxylase gene ARO10 and the aromatic amino acid aminotransferase gene ARO8 were introduced into Escherichia coli to generate two recombinant tyrosol producers. Deleting the prephenate dehydratase gene pheA and the phenylacetaldehyde dehydrogenase gene feaB improved the tyrosol production...
June 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28526925/polyphenolic-extract-attenuates-fatty-acid-induced-steatosis-and-oxidative-stress-in-hepatic-and-endothelial-cells
#9
Laura Vergani, Giulia Vecchione, Francesca Baldini, Elena Grasselli, Adriana Voci, Piero Portincasa, Pier Francesco Ferrari, Bahar Aliakbarian, Alessandro A Casazza, Patrizia Perego
PURPOSE: Phenolic compounds (PC) of virgin olive oil exert several biochemical and pharmacological beneficial effects. Some dietary PC seem to prevent/improve obesity and metabolic-related disorders such as non-alcoholic fatty liver disease (NAFLD). We investigated the possible effects of PC extracted from olive pomace (PEOP) and of the main single molecules present in the extract (tyrosol, apigenin, oleuropein, p-coumaric and caffeic acid) in protecting hepatocytes and endothelial cells against triglyceride accumulation and oxidative stress...
May 19, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28497968/chemoenzymatic-synthesis-and-%C3%AE-glucosidase-inhibitory-activity-of-dimeric-neolignans-inspired-by-magnolol
#10
Luana Pulvirenti, Vera Muccilli, Nunzio Cardullo, Carmela Spatafora, Corrado Tringali
A chemoenzymatic synthesis of a small library of dimeric neolignans inspired by magnolol (1) is reported. The 2-iodoxybenzoic acid (IBX)-mediated regioselective ortho-hydroxylation of magnolol is described, affording the bisphenols 6 and 7. Further magnolol analogues (12, 13, 15-17, 19-23) were obtained from eugenol (3), tyrosol (4), and homovanillic alcohol (5), through horseradish peroxidase (HRP)-mediated oxidative coupling and regioselective ortho-hydroxylation or ortho-demethylation in the presence of IBX, followed by reductive treatment with Na2S2O4...
May 12, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28486416/transcriptomics-and-the-mediterranean-diet-a-systematic-review
#11
REVIEW
Luis V Herrera-Marcos, José M Lou-Bonafonte, Carmen Arnal, María A Navarro, Jesús Osada
The Mediterranean diet has been proven to be highly effective in the prevention of cardiovascular diseases and cancer and in decreasing overall mortality. Nowadays, transcriptomics is gaining particular relevance due to the existence of non-coding RNAs capable of regulating many biological processes. The present work describes a systematic review of current evidence supporting the influence of the Mediterranean diet on transcriptomes of different tissues in various experimental models. While information on regulatory RNA is very limited, they seem to contribute to the effect...
May 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28481240/soft-ms-and-computational-mapping-of-oleuropein
#12
REVIEW
Luigi Gentile, Nicola A Uccella, Ganapathy Sivakumar
Olive oil and table olives are rich sources of biophenols, which provides a unique taste, aroma and potential health benefits. Specifically, green olive drupes are enriched with oleuropein, a bioactive biophenol secoiridoid. Olive oil contains hydrolytic derivatives such as hydroxytyrosol, oleacein and elenolate from oleuropein as well as tyrosol and oleocanthal from ligstroside. Biophenol secoiridoids are categorized by the presence of elenoic acid or its derivatives in their molecular structure. Medical studies suggest that olive biophenol secoiridoids could prevent cancer, obesity, osteoporosis, and neurodegeneration...
May 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28427293/beneficial-effects-of-tyrosol-on-altered-glycoprotein-components-in-streptozotocin-induced-diabetic-rats
#13
Ramasamy Chandramohan, Settu Saravanan, Leelavinothan Pari
CONTEXT: Olive oil is the major source of tyrosol which is a natural phenolic antioxidant. Olive oil constitutes a major component of the Mediterranean diet that is linked to a reduced incidence of chronic diseases. OBJECTIVE: This study evaluates the effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Diabetes mellitus was induced in male Wistar rats by streptozotocin (40 mg/kg body weight)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28417085/hepatoprotective-standardized-etoh-water-extract-from-the-seeds-of-fraxinus-rhynchophylla-hance
#14
Sen Guo, Tiantian Guo, Ni Cheng, Qingchao Liu, Yunting Zhang, Lu Bai, Li Zhang, Wei Cao, Chi-Tang Ho, Naisheng Bai
Fraxinus rhynchophylla Hance (Oleaceae), its stem barks are known as Cortex fraxini ( qín pí) listed in Chinese Pharmacopoeia. Phytochemical study has indicated that methanol extracts from Qinpi has protective effect on acute liver injury. The present study investigates the hepatoprotective activity of EtOH-water extract from the seeds of F. rhynchophylla Hance against carbon tetrachloride-induced liver injury in mice. The EtOH-water extract significantly alleviated liver damage as indicated by the decreased levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the malondialdehyde (MDA) content, and increased the levels of superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GSH-Px), and reduced the pathological tissue injury induced by CCl4...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28398744/natural-products-of-picea-endophytes-from-the-acadian-forest
#15
David R McMullin, Blake D Green, Natasha C Prince, Joey B Tanney, J David Miller
Endophytes of healthy needles were collected from Picea rubens (red spruce) and P. mariana (black spruce) in a survey of southeastern New Brunswick, Canada. Four endophyte strains were selected for further investigation based on the production of biologically active extracts from culture filtrates during screening as well as phylogenetic relationship to species known to produce natural products or taxonomic novelty. A novel endophyte within the family Rhytismataceae produced two new dihydropyrones (1 and 2) as major metabolites together with phthalides (3 and 4), isocoumarins (5 and 6), and tyrosol (7)...
April 11, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28381091/differential-off-line-lc-nmr-dolc-nmr-metabolomics-to-monitor-tyrosine-induced-metabolome-alterations-in-saccharomyces-cerevisiae
#16
Richard Hammerl, Oliver Frank, Thomas Hofmann
A novel differential off-line LC-NMR approach (DOLC-NMR) was developed to capture and quantify nutrient-induced metabolome alterations in Saccharomyces cerevisiae. Off-line coupling of HPLC separation and (1)H NMR spectroscopy supported by automated comparative bucket analyses, followed by quantitative (1)H NMR using ERETIC 2 (electronic reference to access in vivo concentrations), has been successfully used to quantitatively record changes in the metabolome of S. cerevisiae upon intervention with the aromatic amino acid l-tyrosine...
April 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28361236/efficient-synthesis-of-tyrosol-galactosides-by-the-%C3%AE-galactosidase-from-enterobacter-cloacae-b5
#17
Tingting Qi, Guofeng Gu, Li Xu, Min Xiao, Lili Lu
In this work, the β-galactosidase from Enterobacter cloacae B5 (BgaB5) exhibited excellent transglycosylation activity toward tyrosol (p-hydroxyphenethyl alcohol) when using lactose as the glycosyl donor, generating a series of tyrosol glycosides with potential pharmacological properties. The effects of substrate concentration, temperature, pH, and reaction time on the transglycosylation reaction catalyzed by the enzyme BgaB5 were studied in detail. Three tyrosol derivatives were produced in a total high yield of 50...
March 30, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28360012/assessment-of-olea-europaea-l-fruit-extracts-phytochemical-characterization-and-anticancer-pathway-investigation
#18
Amina Maalej, Zouhaier Bouallagui, Fatma Hadrich, Hiroko Isoda, Sami Sayadi
Olea europaea L. has been widely used as an advantageous rich source of bioactive compounds of high economic value leading to its use in pharmaceutical, cosmetic, and agriculture industries. Ethanolic extracts of olive fruits from three different cultivars (OFE) were studied for their phytochemical contents and were investigated for antioxidant activities and anticancer potential. Major polyphenols detected in these extracts were tyrosol, hydroxytyrosol, oleuropein, rutin, quercetin and glucoside forms of luteolin and apigenin...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28352078/mining-of-efficient-microbial-udp-glycosyltransferases-by-motif-evolution-cross-plant-kingdom-for-application-in-biosynthesis-of-salidroside
#19
Bo Fan, Tianyi Chen, Sen Zhang, Bin Wu, Bingfang He
The plant kingdom provides a large resource of natural products and various related enzymes are analyzed. The high catalytic activity and easy genetically modification of microbial enzymes would be beneficial for synthesis of natural products. But the identification of functional genes of target enzymes is time consuming and hampered by many contingencies. The potential to mine microbe-derived glycosyltransferases (GTs) cross the plant kingdom was assessed based on alignment and evolution of the full sequences and key motifs of target enzymes, such as Rhodiola-derived UDP-glycosyltransferase (UGT73B6) using in salidroside synthesis...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28322962/understanding-the-link-between-antimicrobial-properties-of-dietary-olive-phenolics-and-bacterial-atp-synthase
#20
Amon Amini, Mason Liu, Zulfiqar Ahmad
The naturally occurring olive phenolics tyrosol, hydroxytyrosol, dihydroxyphenylglycol (DHPG), and oleuropein are known to have antioxidant, antitumor, and antibacterial properties. In the current study, we examined whether the antimicrobial properties of tyrosol, hydroxytyrosol, DHPG, and oleuropein were linked to the inhibition of bacterial ATP synthase. Tyrosol, hydroxytyrosol, DHPG, and oleuropein inhibited Escherichia coli wild-type and mutant membrane-bound F1Fo ATP synthase to variable degrees. The growth properties of wild-type, null, and mutant strains in presence of above olive phenolics were also abrogated to variable degrees on limiting glucose and succinate...
August 2017: International Journal of Biological Macromolecules
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