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Christoph Schell, Benedikt Sabass, Martin Helmstaedter, Felix Geist, Ahmed Abed, Mako Yasuda-Yamahara, August Sigle, Jasmin I Maier, Florian Grahammer, Florian Siegerist, Nadine Artelt, Nicole Endlich, Dontscho Kerjaschki, Hans-Henning Arnold, Jörn Dengjel, Manuel Rogg, Tobias B Huber
Podocytes, highly specialized epithelial cells, build the outer part of the kidney filtration barrier and withstand high mechanical forces through a complex network of cellular protrusions. Here, we show that Arp2/3-dependent actin polymerization controls actomyosin contractility and focal adhesion maturation of podocyte protrusions and thereby regulates formation, maintenance, and capacity to adapt to mechanical requirements of the filtration barrier. We find that N-WASP-Arp2/3 define the development of complex arborized podocyte protrusions in vitro and in vivo...
November 26, 2018: Developmental Cell
Christo Buizert, Michael Sigl, Mirko Severi, Bradley R Markle, Justin J Wettstein, Joseph R McConnell, Joel B Pedro, Harald Sodemann, Kumiko Goto-Azuma, Kenji Kawamura, Shuji Fujita, Hideaki Motoyama, Motohiro Hirabayashi, Ryu Uemura, Barbara Stenni, Frédéric Parrenin, Feng He, T J Fudge, Eric J Steig
The mid-latitude westerly winds of the Southern Hemisphere play a central role in the global climate system via Southern Ocean upwelling1 , carbon exchange with the deep ocean2 , Agulhas leakage (transport of Indian Ocean waters into the Atlantic)3 and possibly Antarctic ice-sheet stability4 . Meridional shifts of the Southern Hemisphere westerly winds have been hypothesized to occur5,6 in parallel with the well-documented shifts of the intertropical convergence zone7 in response to Dansgaard-Oeschger (DO) events- abrupt North Atlantic climate change events of the last ice age...
November 2018: Nature
Ashish K Sharma, Stephen H Leppla, Andrei P Pomerantsev, Joseph Shiloach
Protective antigen (PA) of Bacillus anthracis is being considered as a vaccine candidate against anthrax and its production has been explored in several heterologous host systems. Since the systems tested introduced adverse issues such as inclusion body formation and endotoxin contamination, the production from B. anthracis is considered as a preferred method. The present study examines the effect of PA expression on the metabolism of B. anthracis producing strain, BH500, by comparing it with a control strain carrying an empty plasmid...
October 31, 2018: Scientific Reports
Martin Sigl, Ulrich Beschorner, Thomas Zeller, Matthias Waliszewski, Ralf Langhoff, Jörg Tautenhahn, Klaus Amendt
INTRODUCTION: The purpose of this observational study is to report the 12-month clinical outcomes with the novel Multiple Stent Delivery System (MSDS) to treat complex femoropopliteal lesions. Previously, we reported the 6-month clinical outcomes of the all-comers LOCOMOTIVE study, which demonstrated the safety and efficacy of the MSDS with a favorable target lesion revascularization (TLR) rate of 5.3% and a 90.7% patency rate at 6 months in claudicants and critical limb ischemia patients...
October 25, 2018: Cardiovascular and Interventional Radiology
Aya K Khamis, Sherif Elsharkawy
Data sourcesThe databases searched were the Cochrane Library, PubMed/Medline, Embase, ISI Web of Knowledge, Scopus and SIGLE OpenGrey. Databases were searched with no restriction on year of publication or language.Study selectionRandomised controlled clinical trials (RCTs), prospective and retrospective studies, case-control studies and case series studies in humans were included. The test group received implants with the local delivery of bisphosphonates, controls received implants only. Studies involving patients with metabolic bone diseases or undergoing systemic medications for bone bio-modulation or immunosuppression or with relevant pathologies were excluded...
October 2018: Evidence-based Dentistry
Juliana L de Geus, Leticia M Wambier, Thaynara F Boing, Alessandro D Loguercio, Alessandra Reis
The aim of this study was to compare preventive ibuprofen administration to placebo on the efficacy of inferior alveolar nerve block in patients with irreversible pulpitis. A search was performed in PubMed, Scopus, Web of Science, LILACS, BBO, Cochrane Library, SIGLE, and grey literature. The risk of bias was evaluated through the Cochrane Collaboration's tool. The quality of evidence was assessed using the GRADE approach. Only seven studies remained for the meta-analysis. Administering ibuprofen before anaesthesia increased the success rate of injectable anaesthesia (RR = 1...
October 7, 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
Christoph Gassner, Frauke Degenhardt, Stefan Meyer, Caren Vollmert, Nadine Trost, Kathrin Neuenschwander, Yvonne Merki, Claudia Portmann, Sonja Sigurdardottir, Antigoni Zorbas, Charlotte Engström, Jochen Gottschalk, Soraya Amar El Dusouqui, Sophie Waldvogel-Abramovski, Emmanuel Rigal, Jean-Daniel Tissot, Caroline Tinguely, Simon M Mauvais, Amira Sarraj, Daniel Bessero, Michele Stalder, Laura Infanti, Andreas Buser, Jörg Sigle, Tina Weingand, Damiano Castelli, Monica C Braisch, Jutta Thierbach, Sonja Heer, Thomas Schulzki, Michael Krawczak, Andre Franke, Beat M Frey
Background: High-frequency blood group antigens (HFA) are present in >90% of the human population, according to some reports even in >99% of individuals. Therefore, patients lacking HFA may become challenging for transfusion support because compatible blood is hardly found, and if the patient carries alloantibodies, the cross-match will be positive with virtual every red cell unit tested. Methods: In this study, we applied high-throughput blood group SNP genotyping on >37,000 Swiss blood donors, intending to identify homozygous carriers of low-frequency blood group antigens (LFA)...
July 2018: Transfusion Medicine and Hemotherapy
Natália Ferreira, Danielle Masterson, Rodrigo Lopes de Lima, Brenda de Souza Moura, Aleli T Oliveira, Tatiana Kelly da Silva Fidalgo, Antônio C P Carvalho, Marcos F DosSantos, Eduardo Grossmann
OBJECTIVE: To perform a systematic review of the viscosupplementation effectiveness with hyaluronic acid (HA) in the articular Temporomandibular Dysfunctions (TMDs) clinical management. METHOD: Electronic searches were performed in the following databases: MEDLINE (via PubMed), Scopus, Web of Science, Cochrane Library, EMBASE, LILACS, BBO, SIGLE (System for Information on Grey Literature in Europe),, and the Brazilian Clinical Trials Registry (ReBec)...
August 27, 2018: Journal of Cranio-maxillo-facial Surgery
Loyse M Fernandes, José Cordeiro L Neto, Thiago F R Lima, Marcela B Magno, Bianca M Santiago, Yuri W Cavalcanti, Leopoldina de Fátima Dantas de Almeida
BACKGROUND/AIMS: The evidence that mouthguards prevent dental trauma is inconsistent. The aim of this study was to determine, through a systematic review and meta-analysis (MA), the impact of mouthguards (MG) on the prevalence of dento-alveolar trauma (DT) among athletes of contact sports. MATERIAL AND METHODS: Searches were performed at Medline, Scopus, Web of Science, Lilacs, Cochrane Library, and SIGLE without restriction of language or publication date. After the application of eligibility criteria, studies were evaluated regarding their methodology quality and risk of bias...
September 17, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Leah T Sigle, Julián F Hillyer
A powerful immune system protects mosquitoes from pathogens and influences their ability to transmit disease. The mosquito's immune and circulatory systems are functionally integrated, whereby intense immune processes occur in areas of high hemolymph flow. The primary circulatory organ of mosquitoes is the dorsal vessel, which consists of a thoracic aorta and an abdominal heart. In adults of the African malaria mosquito, Anopheles gambiae , the heart periodically alternates contraction direction, resulting in intracardiac hemolymph flowing toward the head (anterograde) and toward the posterior of the abdomen (retrograde)...
2018: Frontiers in Physiology
Ulf Büntgen, Lukas Wacker, J Diego Galván, Stephanie Arnold, Dominique Arseneault, Michael Baillie, Jürg Beer, Mauro Bernabei, Niels Bleicher, Gretel Boswijk, Achim Bräuning, Marco Carrer, Fredrik Charpentier Ljungqvist, Paolo Cherubini, Marcus Christl, Duncan A Christie, Peter W Clark, Edward R Cook, Rosanne D'Arrigo, Nicole Davi, Ólafur Eggertsson, Jan Esper, Anthony M Fowler, Ze'ev Gedalof, Fabio Gennaretti, Jussi Grießinger, Henri Grissino-Mayer, Håkan Grudd, Björn E Gunnarson, Rashit Hantemirov, Franz Herzig, Amy Hessl, Karl-Uwe Heussner, A J Timothy Jull, Vladimir Kukarskih, Alexander Kirdyanov, Tomáš Kolář, Paul J Krusic, Tomáš Kyncl, Antonio Lara, Carlos LeQuesne, Hans W Linderholm, Neil J Loader, Brian Luckman, Fusa Miyake, Vladimir S Myglan, Kurt Nicolussi, Clive Oppenheimer, Jonathan Palmer, Irina Panyushkina, Neil Pederson, Michal Rybníček, Fritz H Schweingruber, Andrea Seim, Michael Sigl, Olga Churakova Sidorova, James H Speer, Hans-Arno Synal, Willy Tegel, Kerstin Treydte, Ricardo Villalba, Greg Wiles, Rob Wilson, Lawrence J Winship, Jan Wunder, Bao Yang, Giles H F Young
Though tree-ring chronologies are annually resolved, their dating has never been independently validated at the global scale. Moreover, it is unknown if atmospheric radiocarbon enrichment events of cosmogenic origin leave spatiotemporally consistent fingerprints. Here we measure the 14 C content in 484 individual tree rings formed in the periods 770-780 and 990-1000 CE. Distinct 14 C excursions starting in the boreal summer of 774 and the boreal spring of 993 ensure the precise dating of 44 tree-ring records from five continents...
September 6, 2018: Nature Communications
Bruna Maria de Carvalho Martins, Emmanuel João Nogueira Leal da Silva, Daniele Masterson Tavares Pereira Ferreira, Kátia Rodrigues Reis, Tatiana Kelly da Silva Fidalgo
OBJECTIVES: This systematic review aimed to verify if there is difference in the longevity of minimally invasive techniques compared to the complete replacement for the treatment of defective direct restorations in permanent teeth. DATA: The data included randomized controlled clinical trials comparing the clinical performance of defective dental restorations treated by a complete replacement technique or minimally invasive techniques on permanent teeth. Evaluation of the risk of bias was performed using the Cochrane Collaboration common scheme for bias and the evidence was qualified using the GRADE tool...
November 2018: Journal of Dentistry
Christoph Niederhauser, Nadja Widmer, Magdalena Hotz, Caroline Tinguely, Stefano Fontana, Gabrielle Allemann, Mauro Borri, Laura Infanti, Amira Sarraj, Jörg Sigle, Michèle Stalder, Jutta Thierbach, Sophie Waldvogel, Tina Wiengand, Max Züger, Peter Gowland
Background and aimHepatitis E virus (HEV) is a virus of emerging importance to transfusion medicine. Studies from several European countries, including Switzerland, have reported high seroprevalence of hepatitis E as a consequence of endemic infections. Published HEV seroprevalence estimates within developed countries vary considerably; primarily due to improved diagnostic assays. The purpose of this study was to investigate the seroprevalence of anti-HEV IgG in Swiss blood donations. Methods: We used the highly sensitive Wantai HEV IgG EIA and assessed regional distribution patterns...
August 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Wentian Sun, Kai Xia, Li Tang, Chenlu Liu, Ling Zou, Jun Liu
OBJECTIVE: To investigate the accuracy of panoramic radiography (PR) in diagnosing maxillary sinus-root relationships (SRRs). MATERIALS AND METHODS: PubMed, EMBASE, CENTRAL, Web of Science, ScienceDirect, CBM, Baidu Scholar, and SIGLE were searched. The studies comparing the diagnostic accuracy of PR and computed tomography/cone-beam computed tomography (CT/CBCT) for SRR were included. RESULTS: Eleven studies were included. Meta-analyses showed that, for type I SRR, PR had the highest specificity, positive likelihood ratio (+LR), diagnostic odds ratio (DOR), and area under the curve (AUC), with a high sensitivity and a low negative LR (-LR)...
November 2018: Angle Orthodontist
Lisa Sigl, Liudvika Leišytė
The ways in which societies and institutions institutionalize and practice invention management reflects not only how new ideas are valued, but also imaginaries about the role of science and technology for societal development. Often taking the US Bayh-Dole-Act as a model, many European states have recently implemented changes in how inventions at academic institutions are to be handled to optimize their societal impact. We analyze how these changes have been taken up-and made sense of-in regions with different pre-existing infrastructures, practices and semantics of invention management...
2018: Minerva
M Haalboom, M H E Blokhuis-Arkes, R J Beuk, R Meerwaldt, R Klont, M J Schijffelen, P B Bowler, M Burnet, E Sigl, J A M van der Palen
OBJECTIVES: The aim of this study was to determine whether assessment of wound infection differs when culture results from wound biopsy versus wound swab are available in clinical practice. METHODS: For 180 eligible patients, a swab and biopsy were taken from one wound during a regular appointment at a wound care facility in eastern Netherlands. Culture results from both methods were supplemented with clinical information and provided to a panel of six experts who independently assessed each wound as infect or not, separately for swab and biopsy...
August 24, 2018: Clinical Microbiology and Infection
Ross Macmillan, Naila Shofia, Wendy Sigle
There is considerable speculation that female political empowerment could improve population health. Yet, evidence to date is limited, and explanations for why political empowerment would matter and the conditions under which this might be enhanced or muted are not well understood. In this article, we draw on theoretical work on the politics of representation to frame an investigation of whether increases in the percentage of females in a country's parliament influence mortality rates. We further examine whether the relationship is conditioned by extent of democracy and economic and social development...
October 2018: Demography
Anand Kumar, Ryan Zarychanski, Amarnath Pisipati, Aseem Kumar, Shravan Kethireddy, Eric J Bow
The purpose of this study was to determine whether fungicidal versus fungistatic pharmacotherapy of invasive candidiasis/candidemia yields superior outcomes. Data sources included MEDLINE (1966-June 2017), EMBASE (1980-June 2017), PubMed (1966-June 2017), Global Health-Ovid (inception to June 2017), LILACS Virtual Health Library (inception to June 2017) and the Cochrane Central Register of Controlled Trials (to 2nd quarter 2017). The database, the SCOPUS database, SIGLE (System for Information on Grey Literature) and Google Scholar were also utilised to search for relevant studies...
2018: Mycology
Raphael Schuster, Sophia Sigl, Thomas Berger, Anton-Rupert Laireiter
BACKGROUND: Blended group therapy combines group sessions with Web- and mobile-based treatment modules. Consequently, blended group therapy widens the choice within blended interventions at reasonable costs. This is the first qualitative study on blended group therapy. OBJECTIVE: The objective of this study was to investigate the patient-centered feasibility of blended group therapy for major depression, with special emphasis on the fit and dynamic interplay between face-to-face and internet-based elements...
July 11, 2018: JMIR Mental Health
J L de Geus, L M Wambier, T F Boing, A D Loguercio, A Reis
OBJECTIVE: To perform a systematic review to answer the following research question: Is at-home bleaching in adults with more concentrated carbamide peroxide (CP) gels as effective and safe as bleaching performed with 10% carbamide peroxide gels? METHODS AND MATERIALS: A comprehensive search was carried out in the MEDLINE via PubMed, Scopus, Web of Science, LILACS, BBO, Cochrane Library and SIGLE, without restrictions. IADR abstracts (1990 to 2016) and unpublished and ongoing trial registries, dissertations and theses (ProQuest Dissertations and Periodicos Capes Theses Databases) were also searched...
July 2018: Operative Dentistry
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