keyword
https://read.qxmd.com/read/34930362/p2y12-receptor-as-a-new-target-for-electroacupuncture-relieving-comorbidity-of-visceral-pain-and-depression-of-inflammatory-bowel-disease
#21
JOURNAL ARTICLE
Yanzhen Li, Hong Zhang, Jingwen Yang, Muouyang Zhan, Xuefei Hu, Yongmin Liu, Lingling Yu, Xiaochen Yan, Shangdong Liang, Ruyue Zhang, Ying Lu, Beining Li, Cunzhi Liu, Man Li
BACKGROUND: The P2Y12 receptor is a kind of purinoceptor that is engaged in platelet aggregation, and P2Y12 inhibitors have been used in clinical antithrombotic therapy. The P2Y12 receptor in microglia induces interleukin-1β (IL-1β) expression, which is a key mediator of depression in the brain. Although peripheral P2Y12 is involved in neuropathic pain, whether P2Y12 expression in the medial prefrontal cortex (mPFC) is associated with comorbidities of visceral pain and depression remains unclear...
December 20, 2021: Chinese Medicine
https://read.qxmd.com/read/34671215/prg-1-relieves-pain-and-depressive-like-behaviors-in-rats-of-bone-cancer-pain-by-regulation-of-dendritic-spine-in-hippocampus
#22
JOURNAL ARTICLE
Xingfeng Liu, Zhuo Xie, Site Li, Jingxin He, Song Cao, Zhi Xiao
Rationale: Pain and depression, which tend to occur simultaneously and share some common neural circuits and neurotransmitters, are highly prevalent complication in patients with advanced cancer. Exploring the underlying mechanisms is the cornerstone to prevent the comorbidity of chronic pain and depression in cancer patients. Plasticity-related gene 1 (PRG-1) protein regulates synaptic plasticity and brain functional reorganization during neuronal development or after cerebral lesion. Purinergic P2X7 receptor has been proposed as a therapeutic target for various pain and neurological disorders like depression in rodents...
2021: International Journal of Biological Sciences
https://read.qxmd.com/read/34521603/material-and-sedation-analgesia-in-the-neonatal-lumbar-puncture-procedure
#23
JOURNAL ARTICLE
Sara Jimeno Ruiz, Mónica Riaza Gómez, José Miguel Cárdenas Rebollo, Alejandro López-Escobar
INTRODUCTION: Lumbar puncture (LP) is a frequent procedure during the neonatal period. Correctly performing this technique can avoid many of its complications. OBJECTIVE: To evaluate the LP procedure in neonates in Spanish hospitals, studying the type of material and the sedation-analgesia used. MATERIAL AND METHODS: Cross-sectional study conducted in Spain gathering data through a survey research distributed by email through the Segurneo-SEN Hospital Network and the Spanish Neonatal Society...
September 11, 2021: Anales de pediatría
https://read.qxmd.com/read/34510137/behavioral-outcomes-of-complete-freund-adjuvant-induced-inflammatory-pain-in-the-rodent-hind-paw-a-systematic-review-and-meta-analysis
#24
JOURNAL ARTICLE
Dominika J Burek, Nicolas Massaly, Hye Jean Yoon, Michelle Doering, Jose A Morón
Many analgesics inadequately address the psychiatric comorbidities of chronic and persistent pain, but there is no standard preclinical model of pain-altered behavior to support the development of new therapies. To explore this conflicting and inconclusive literature, we conducted a focused systematic review and meta-analysis on the effect of complete Freund adjuvant-induced (CFA) rodent hind paw inflammation on multiple classical indicators of exploratory behavior, stress coping, and naturalistic behavior...
May 1, 2022: Pain
https://read.qxmd.com/read/34371971/synergistic-interaction-in-the-analgesic-like-effects-of-maqui-berry-and-citrus-is-antagonized-by-sweeteners
#25
JOURNAL ARTICLE
Vicente Agulló, María Eva González-Trujano, Alberto Hernandez-Leon, Erika Estrada-Camarena, Francisco Pellicer, Cristina García-Viguera
Although physiologically pain has a protective function, in many diseases, it is one of the most prominent symptoms. Today, new trends are focused on finding more natural alternatives to conventional treatments to alleviate it. Thereby, the purpose of this investigation was to obtain preclinical data of the antinociceptive properties of a lyophilized obtained from a newly designed maqui-citrus beverage alone and added with different sweeteners. To achieve this objective, maqui berry and citrus pharmacological activity were studied separately, as well as the interaction of both ingredients...
July 19, 2021: Nutrients
https://read.qxmd.com/read/33337532/-pediatric-pain-treatment-and-prevention-for-hospitalized-children
#26
REVIEW
Stefan J Friedrichsdorf, Liesbet Goubert
INTRODUCTION: Prevention and treatment of pain in pediatric patients compared with adults is often not only inadequate but also less often implemented the younger the children are. Children 0 to 17 years are a vulnerable population. OBJECTIVES: To address the prevention and treatment of acute and chronic pain in children, including pain caused by needles, with recommended analgesic starting doses. METHODS: This Clinical Update elaborates on the 2019 IASP Global Year Against Pain in the Vulnerable "Factsheet Pain in Children: Management" and reviews best evidence and practice...
June 2021: Der Schmerz
https://read.qxmd.com/read/33036929/pain-control-in-neonatal-male-circumcision-a-best-evidence-review
#27
REVIEW
Muhieddine Labban, Zahraa Menhem, Tarek Bandali, Layal Hneiny, Ahmad Zaghal
OBJECTIVE: Routine male infant circumcision (RMIC) is a common procedure that inadvertently causes significant but preventable pain. In this best evidence review, we examine the available pain management options and their effectiveness for RMIC. MATERIAL AND METHODS: The Medline (OVID) and Cochrane library were searched for randomized controlled trials investigating pain control for RMIC. Only trials that included newborns younger than 45 days of age were included...
February 2021: Journal of Pediatric Urology
https://read.qxmd.com/read/32998845/-material-and-sedation-analgesia-in-the-neonatal-lumbar-puncture-procedure
#28
JOURNAL ARTICLE
Sara Jimeno Ruiz, Mónica Riaza Gómez, José Miguel Cárdenas Rebollo, Alejandro López-Escobar
INTRODUCTION: Lumbar puncture (LP) is a frequent procedure during the neonatal period. Correctly performing this technique can avoid many of its complications. OBJECTIVE: To evaluate the LP procedure in neonates in Spanish hospitals, studying the type of material and the sedation-analgesia used. MATERIAL AND METHODS: Cross-sectional study conducted in Spain gathering data through a survey research distributed by email through the Segurneo-SEN Hospital Network and the Spanish Neonatal Society...
September 27, 2020: Anales de pediatría
https://read.qxmd.com/read/32704547/sweet-taste-does-not-modulate-pain-perception-in-adult-humans
#29
JOURNAL ARTICLE
Elizabeth R Mooney, Alexander J Davies, Anthony E Pickering
Background : It is commonly observed that humans who are in pain or discomfort seek solace in the form of sweet foods and drinks. Sugar is routinely used to comfort neonates undergoing painful procedures, and animal studies have shown that sucrose increases the time to withdrawal from painful stimuli. However, there are no published studies examining the effects of sweet substances on heat pain thresholds and percept in adult humans. Methods : Healthy adult volunteers (n=27, aged 18-48 years) were recruited to a controlled, double-blind, randomised, cross-over study to characterise the effect of tasting solutions of equivalent sweetness (10% sucrose and 0...
2020: Wellcome Open Research
https://read.qxmd.com/read/32564489/effects-of-combined-use-of-mother-s-breast-milk-heartbeat-sounds-and-non-nutritive-sucking-on-preterm-infants-behavioral-stress-during-venipuncture-a-randomized-controlled-trial
#30
RANDOMIZED CONTROLLED TRIAL
Hsiang-Ping Wu, Luke Yang, Hsiang-Yun Lan, Hsueh-Fang Peng, Yue-Cune Chang, Mei-Jy Jeng, Jen-Jiuan Liaw
PURPOSE: Even routine procedures can cause pain and stress, and can be harmful to the fast-growing brain of preterm infants. Mitigating pain and stress with sucrose and analgesics has side effects; thus, an alternate choice is the use of natural breast milk and infants' sensory capabilities. Therefore, this study examined the effects of different integrations of sensory experiences-mother's breast milk odor and taste (BM-OT), heartbeat sounds (HBs), and non-nutritive sucking (NNS)-on preterm infant's behavioral stress during venipuncture...
September 2020: Journal of Nursing Scholarship
https://read.qxmd.com/read/32402558/modified-sensory-stimulation-using-breastmilk-for-reducing-pain-intensity-in-neonates-in-indonesia-a-randomized-controlled-trial
#31
RANDOMIZED CONTROLLED TRIAL
Siti Yuyun Rahayu Fitri, Lely Lusmilasari, Mohammad Juffrie, Carlo Valerio Bellieni
PURPOSE: Several studies have shown that oral sucrose reduces pain in newborns. However, sucrose has no efficacy in eliminating pain and long-term effects remain unclear. Breast milk may be useful as an alternative, safe sweet solution. Sensorial saturation (SS) is a multisensory analgesic non-pharmacological treatment, which includes touch and sounds as distractors. This study aimed to compare the analgesic effects of SS with sucrose (SSS), SS with breast milk (SSB), and oral sucrose alone (S24%) in neonates undergoing venipuncture...
July 2020: Journal of Pediatric Nursing
https://read.qxmd.com/read/32389751/cebranopadol-reduces-cocaine-self-administration-in-male-rats-dose-treatment-and-safety-consideration
#32
JOURNAL ARTICLE
Huimei Wei, Ting Zhang, Chang-Guo Zhan, Fang Zheng
As a novel first-in-class potent analgesic acting as an agonist of multiple opioid receptors, cebranopadol showed high efficacy and good tolerability in a broad range of preclinical models and clinical trials related to pain. In the present study, to evaluate the efficacy and safety of cebranopadol as a potential treatment of cocaine dependence, we tested the effects of cebranopadol with single and repeated doses (25, 50, 75, or 100 μg/kg, oral gavage) using rat models of cocaine fixed-ratio (FR) self-administration (SA), cocaine progressive-ratio (PR) SA, and sucrose pellet SA...
August 1, 2020: Neuropharmacology
https://read.qxmd.com/read/32072099/pediatric-pain-treatment-and-prevention-for-hospitalized-children
#33
JOURNAL ARTICLE
Stefan J Friedrichsdorf, Liesbet Goubert
INTRODUCTION: Prevention and treatment of pain in pediatric patients compared with adults is often not only inadequate but also less often implemented the younger the children are. Children 0 to 17 years are a vulnerable population. OBJECTIVES: To address the prevention and treatment of acute and chronic pain in children, including pain caused by needles, with recommended analgesic starting doses. METHODS: This Clinical Update elaborates on the 2019 IASP Global Year Against Pain in the Vulnerable "Factsheet Pain in Children: Management" and reviews best evidence and practice...
2020: Pain Reports
https://read.qxmd.com/read/32071073/the-operant-plantar-thermal-assay-a-novel-device-for-assessing-thermal-pain-tolerance-in-mice
#34
JOURNAL ARTICLE
Ashlie N Reker, Sisi Chen, Katherine Etter, Taylor Burger, Makayla Caudill, Steve Davidson
Pain is a multi-dimensional experience of sensory-discriminative, cognitive, and affective processes; however, current basic research methods rely heavily on response to threshold stimuli, bypassing the supraspinal processing that ultimately gives rise to the pain experience. We developed the Operant Planter Thermal Assay (OPTA), which utilizes a novel, conflict-based operant task requiring evaluation and active decision making to obtain reward under thermally aversive conditions to quantify thermal pain tolerance...
February 13, 2020: ENeuro
https://read.qxmd.com/read/31987233/comparison-of-the-analgesic-effect-of-oral-sucrose-and-or-music-in-preterm-neonates-a-double-blind-randomized-clinical-trial
#35
JOURNAL ARTICLE
Zahra Amirkhanzadeh Barandouzi, Maryam Keshavarz, Ali Montazeri, Hassan Ashayeri, Zahra Rajaei
OBJECTIVE: To compare the analgesic effects of sucrose, music, and their combination on venipuncture's pain in preterm neonates. METHODOLOGY: A double-blinded randomized control trial conducted at a Neonatal Intensive Care Unit (NICU) affiliated to Tehran University of Medical Sciences (TUMS) in Tehran, Iran. One hundred and twenty preterm neonates were randomly allocated into three experimental (sucrose, music and combination of sucrose and music) and one control groups (n = 30 for each group)...
January 2020: Complementary Therapies in Medicine
https://read.qxmd.com/read/31906313/analgesia-effect-of-enteric-sustained-release-tetrodotoxin-pellets-in-the-rat
#36
JOURNAL ARTICLE
Bihong Hong, Jianlin He, Jipeng Sun, Qingqing Le, Kaikai Bai, Yanhua Mou, Yiping Zhang, Weizhu Chen, Wenwen Huang
Tetrodotoxin (TTX) was identified as a latent neurotoxin that has a significant analgesia effect. It was rapidly absorbed and excreted in rat after intramuscular (i.m.) injection. To maintain the effect, frequent injections were required. The enteric sustained-release TTX pellets with sucrose pellets as a drug carrier was prepared by fluidized bed spray irrigation, coated in sequence with Eudragit NE30D as a sustained-release layer, hydroxypropyl methylcellulose (HPMC) as a barrier layer and Eudragit L30D-55 as an enteric coating...
January 1, 2020: Pharmaceutics
https://read.qxmd.com/read/31503069/piperlongumine-produces-antidepressant-like-effects-in-rats-exposed-to-chronic-unpredictable-stress
#37
JOURNAL ARTICLE
Lei Zhang, Chen Liu, Mei Yuan, Chunlan Huang, Lin Chen, Ting Su, Zigen Liao, Lu Gan
Piperlongumine, an alkaloid compound extracted from Peper longum L, has been reported to produce neuroprotective effects in the brain and exert various pharmacological activities such as antitumor, antiangiogenic, anti-inflammatory and analgesic properties. The aim of this study was to investigate the antidepressant-like effects and the possible mechanism of action of piperlongumine in a chronic unpredictable stress (CUS) model. We found that, with venlafaxine as a positive control, orally administered piperlongumine (12...
September 9, 2019: Behavioural Pharmacology
https://read.qxmd.com/read/30917911/early-and-late-anti-nociceptive-effects-of-sucrose-on-neonatal-inflammatory-pain-in-rats-comparison-to-a-non-steroidal-anti-inflammatory-drug
#38
JOURNAL ARTICLE
Khawla Q Nuseir, Ahmad Y Altarifi, Alaa Tasslaq, Ahmd Y Alhusban, Karem H Alzoubi
Management of neonatal pain is not only ethical but is also essential. Barriers to pain management in infants include lack of safe and effective medications and fear of adverse effects of conventional pain medications. Sweet solutions given intraorally have been shown to reduce pain behaviors and associated symptoms. Sucrose and other sweet solutions are being increasingly used at the NICUs and immunization clinics. Sucrose for mild invasive procedures is effective and safe for those procedures that need to be repeated multiple times during the day...
July 1, 2019: Physiology & Behavior
https://read.qxmd.com/read/30555159/dopamine-d-3-r-antagonist-vk4-116-attenuates-oxycodone-self-administration-and-reinstatement-without-compromising-its-antinociceptive-effects
#39
JOURNAL ARTICLE
Zhi-Bing You, Guo-Hua Bi, Ewa Galaj, Vivek Kumar, Jianjing Cao, Alexandra Gadiano, Rana Rais, Barbara S Slusher, Eliot L Gardner, Zheng-Xiong Xi, Amy Hauck Newman
Prescription opioids such as oxycodone are highly effective analgesics for clinical pain management, but their misuse and abuse have led to the current opioid epidemic in the United States. In order to ameliorate this public health crisis, the development of effective pharmacotherapies for the prevention and treatment of opioid abuse and addiction is essential and urgently required. In this study, we evaluated-in laboratory rats-the potential utility of VK4-116, a novel and highly selective dopamine D3 receptor (D3R) antagonist, for the prevention and treatment of prescription opioid use disorders...
November 27, 2018: Neuropsychopharmacology
https://read.qxmd.com/read/30466313/sweet-solutions-for-analgesia-in-neonates-in-china-a-systematic-review-and-meta-analysis
#40
JOURNAL ARTICLE
Rui-Rui Huang, Ri-Hua Xie, Shi Wu Wen, Shao-Lin Chen, Qin She, Yan-Nan Liu, Denise Harrison
INTRODUCTION: High-quality synthesized evidence of sweet taste analgesia in neonates exists. However, Chinese databases have never been included in previous systematic reviews of sweet solutions for procedural pain. OBJECTIVE: To conduct a systematic review of Chinese literature evaluating analgesic effects of sweet solutions for neonates. Data sources: Wang Fang, China National Knowledge Infrastructure and Chinese Biomedical Literature Database. Data extraction and analysis: Two authors screened studies for inclusion and conducted risk of bias ratings and data extraction...
November 22, 2018: Canadian Journal of Nursing Research
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