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https://www.readbyqxmd.com/read/30104865/consumer-opinions-on-adverse-events-associated-with-medicines-and-vaccines
#1
Parisa Aslani, Kim Hamrosi, Vivien Tong, Timothy F Chen, Jane Cook, Romano Fois, Theresa McGarry, Carter Moore, Rodney Peters, Sarah Spagnardi, Karen Whitelock
Introduction: Despite the availability of an Australian consumer adverse event (AE) reporting system for over 50 years, reporting rates remain low. A comprehensive understanding of consumer perceptions and experiences regarding AEs is needed to further ascertain factors impacting their engagement in AE reporting. Aim: The aim of this study was to explore consumer opinions about AEs potentially associated with medicines and vaccines, and their experiences and understanding of managing and reporting AEs...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/30104496/contact-lens-biosensors
#2
REVIEW
Ryan Chang Tseng, Ching-Chuen Chen, Sheng-Min Hsu, Han-Sheng Chuang
Rapid diagnosis and screening of diseases have become increasingly important in predictive and preventive medicine as they improve patient treatment strategies and reduce cost as well as burden on our healthcare system. In this regard, wearable devices are emerging as effective and reliable point-of-care diagnostics that can allow users to monitor their health at home. These wrist-worn, head-mounted, smart-textile, or smart-patches devices can offer valuable information on the conditions of patients as a non-invasive form of monitoring...
August 13, 2018: Sensors
https://www.readbyqxmd.com/read/30103510/antioxidant-activity-of-myrtus-communis-l-and-myrtus-nivellei-batt-trab-extracts-a-brief-review
#3
REVIEW
Aicha Hennia, Maria Graça Miguel, Said Nemmiche
Myrtus communis L. (myrtle) and Myrtus nivellei Batt. & Trab. (Saharan myrtle) have been used in folk medicine for alleviating some ailments. M. communis is largely distributed in the Mediterranean Basin, whereas M. nivellei is confined in specific zones of the central Saharan mountains. The chemical composition and antioxidant activity of berry and leaf extracts isolated from myrtle are deeply documented, whereas those isolated from Saharan myrtle extracts are less studied. In both species, the major groups of constituents include gallic acid derivatives, flavonols, flavonol derivatives, and hydroxybenzoic acids...
August 11, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/30102549/interaction-of-the-saponin-aescin-with-ibuprofen-in-dmpc-model-membranes
#4
Ramsia Sreij, Sylvain François Prévost, Rajeev Dattani, Carina Dargel, Yvonne Hertle, Oliver Wrede, Thomas Hellweg
The understanding of the interaction of drugs with biologically active compounds in biological membranes is of fundamental importance for the evaluation of physiological effects and the development and improvement of medicinal formulations. In the present study we investigate the interaction of the saponin aescin, a biosurfactant which is derived from the horse chestnut tree aesculus hippocastanum, with the non-steroidal anti-inflammatory drug (NSAID) ibuprofen in 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) model membranes...
August 13, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/30102458/design-principles-and-multifunctionality-in-cell-encapsulation-systems-for-tissue-regeneration
#5
REVIEW
Clara R Correia, Rui L Reis, João F Mano
Cell encapsulation systems are being increasingly applied as multifunctional strategies to regenerate tissues. Lessons afforded with encapsulation systems aiming to treat endocrine diseases seem to be highly valuable for the tissue engineering and regenerative medicine (TERM) systems of today, in which tissue regeneration and biomaterial integration are key components. Innumerous multifunctional systems for cell compartmentalization are being proposed to meet the specific needs required in the TERM field. Herein is reviewed the variable geometries proposed to produce cell encapsulation strategies toward tissue regeneration, including spherical and fiber-shaped systems, and other complex shapes and arrangements that better mimic the highly hierarchical organization of native tissues...
August 13, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30101008/cell-cycle-checkpoint-control-the-cyclin-g1-mdm2-p53-axis-emerges-as-a-strategic-target-for-broad-spectrum-cancer-gene-therapy-a-review-of-molecular-mechanisms-for-oncologists
#6
Erlinda M Gordon, Joshua R Ravicz, Seiya Liu, Sant P Chawla, Frederick L Hall
Basic research in genetics, biochemistry and cell biology has identified the executive enzymes and protein kinase activities that regulate the cell division cycle of all eukaryotic organisms, thereby elucidating the importance of site-specific protein phosphorylation events that govern cell cycle progression. Research in cancer genomics and virology has provided meaningful links to mammalian checkpoint control elements with the characterization of growth-promoting proto-oncogenes encoding c-Myc, Mdm2, cyclins A, D1 and G1, and opposing tumor suppressor proteins, such as p53, pRb, p16INK4A and p21WAF1 , which are commonly dysregulated in cancer...
August 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30098792/comprehensive-systematic-review-update-summary-disorders-of-consciousness-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology-the-american-congress-of-rehabilitation-medicine-and-the-national
#7
Joseph T Giacino, Douglas I Katz, Nicholas D Schiff, John Whyte, Eric J Ashman, Stephen Ashwal, Richard Barbano, Flora M Hammond, Steven Laureys, Geoffrey S F Ling, Risa Nakase-Richardson, Ronald T Seel, Stuart Yablon, Thomas S D Getchius, Gary S Gronseth, Melissa J Armstrong
OBJECTIVE: To update the 1995 American Academy of Neurology (AAN) practice parameter on persistent vegetative state and the 2002 case definition for the minimally conscious state (MCS) by reviewing the literature on the diagnosis, natural history, prognosis, and treatment of disorders of consciousness lasting at least 28 days. METHODS: Articles were classified per the AAN evidence-based classification system. Evidence synthesis occurred through a modified Grading of Recommendations Assessment, Development and Evaluation process...
August 7, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/30096335/dynamics-of-a-magnetically-rotated-micro-swimmer-inspired-by-paramecium-metachronal-wave
#8
Ali Nematollahisarvestani, Amir Shamloo
In the past few years, a significant body of research has been devoted to designing magnetic micron scale robotic systems for minimally invasive medicine. The motion of different microorganisms is the nature's solution for efficient propulsion of these swimmers. So far, there has been a considerable effort in designing micro swimmers based on the propulsion of bacteria while the motion of numerous other microorganisms has not been a source of inspiration for designing micro swimmers yet. Inspired by propulsion of Paramecium which is a ciliate microorganism, a novel micro swimmer is proposed in this article which is capable of cargo transport...
August 7, 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/30095453/health-information-counselors-a-new-profession-for-the-age-of-big-data
#9
Amelia Fiske, Alena Buyx, Barbara Prainsack
Health care is increasingly data-driven. Concurrently, there are growing concerns that health professionals lack the time and training to guide patients through the growing medical "data jungle." In the age of big data, ever wider domains of people's lives are "datafied," which renders ever more information-at least in principle-usable for health care purposes. Turning data into meaningful information for clinical practice-and deciding what data or information should not be used for this purpose-requires a significant amount of time, resources, and skill...
August 7, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/30095351/the-exposome-molecules-to-populations
#10
Megan M Niedzwiecki, Douglas I Walker, Roel Vermeulen, Marc Chadeau-Hyam, Dean P Jones, Gary W Miller
Derived from the term exposure, the exposome is an omic-scale characterization of the nongenetic drivers of health and disease. With the genome, it defines the phenome of an individual. The measurement of complex environmental factors that exert pressure on our health has not kept pace with genomics and historically has not provided a similar level of resolution. Emerging technologies make it possible to obtain detailed information on drugs, toxicants, pollutants, nutrients, and physical and psychological stressors on an omic scale...
August 10, 2018: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/30095052/perturbation-theory-machine-learning-models-theory-regulatory-issues-and-applications-to-organic-synthesis-medicinal-chemistry-protein-research-and-technology
#11
Sonia Arrasate, Aliuska Duardo-Sanchez
Machine Learning (ML) models are very useful to predict physicochemical properties of small organic molecules, proteins, proteomes, and complex systems. These methods may be useful to reduce the cost of research in terms of materials resources, time, and laboratory animal sacrifice. Recently different authors have reported Perturbation Theory (PT) methods combined with ML to obtain PTML (PT + ML) models. They have applied PTML models to the study of different biological systems and in technology as well. Here we present one state-of-art review about the different applications of PTML models in Organic Synthesis, Medicinal Chemistry, Protein Research, and Technology...
August 10, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/30093918/accountability-in-the-nhs-the-impact-on-cancer-care
#12
EDITORIAL
Aislinn Macklin-Doherty
Accountability of service delivery is becoming increasingly complex and never has this been more apparent than in the field of Oncology. Cancer care has an unrivalled level of complexity not only in the heterogeneity of management of the disease itself but increasingly in the myriad of service providers, specialities, policymakers and regulatory bodies overseeing its delivery. The stepwise series of changes to NHS structures over recent decades has had an enormous impact on our ability to answer key questions which lie at the heart of accountability: who is making the key decisions about changes to cancer care delivery? What are these reforms achieving? How can they be influenced? It is only through clear and transparent decision-making that we may have any hope of implementing, monitoring and influencing the effects of evidence-based change...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30092820/adipose-tissue-derived-extracellular-fraction-characterization-biological-and-clinical-considerations-in-regenerative-medicine
#13
Barbara Bellei, Emilia Migliano, Marinella Tedesco, Silvia Caputo, Federica Papaccio, Gianluca Lopez, Mauro Picardo
BACKGROUND: Adipose tissue-derived stem cells are considered to be a promising source in the field of cell therapy and regenerative medicine. In addition to direct cell replacement using adipose tissue or purified stem cells, intercellular molecule exchange by the adipose tissue complex, a vast array of bioactive secretory factors, demonstrated beneficial effects by reducing tissue damage and stimulation of endogenous repair. However, for therapeutic purposes, the use of secretome derivatives, such as full conditioned media or purified exosomes generated in vitro, may present considerable disadvantages for cell manufacturing, storage, product safety, and their potential as a ready-to-go therapeutic product...
August 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30092402/the-supercarbonate-apatite-microrna-complex-inhibits-dextran-sodium-sulfate-induced-colitis
#14
Tadafumi Fukata, Tsunekazu Mizushima, Junichi Nishimura, Daisuke Okuzaki, Xin Wu, Haruka Hirose, Yuhki Yokoyama, Yui Kubota, Kazuya Nagata, Naoto Tsujimura, Akira Inoue, Norikatsu Miyoshi, Naotsugu Haraguchi, Hidekazu Takahashi, Taishi Hata, Chu Matsuda, Hisako Kayama, Kiyoshi Takeda, Yuichiro Doki, Masaki Mori, Hirofumi Yamamoto
The incidence of inflammatory bowel disease (IBD) is increasing. Nucleic acid-based medicine has potential as a next-generation treatment, but it is rarely successful with IBD. The aim of this study was to establish a microRNA-based therapy in an IBD model. For this purpose, we used microRNA-29 (miR-29) and a supercarbonate apatite (sCA) nanoparticle as a drug delivery system. Injection of sCA-miR-29a-3p or sCA-miR-29b-3p into mouse tail veins markedly prevented and restored inflammation because of dextran sulfate sodium (DSS)-induced colitis...
August 6, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/30089805/stem-cell-bioengineering-building-from-stem-cell-biology
#15
REVIEW
Mukul Tewary, Nika Shakiba, Peter W Zandstra
New fundamental discoveries in stem cell biology have yielded potentially transformative regenerative therapeutics. However, widespread implementation of stem-cell-derived therapeutics remains sporadic. Barriers that impede the development of these therapeutics can be linked to our incomplete understanding of how the regulatory networks that encode stem cell fate govern the development of the complex tissues and organs that are ultimately required for restorative function. Bioengineering tools, strategies and design principles represent core components of the stem cell bioengineering toolbox...
August 8, 2018: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/30089617/comprehensive-systematic-review-update-summary-disorders-of-consciousness-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology-the-american-congress-of-rehabilitation-medicine-and-the-national
#16
Joseph T Giacino, Douglas I Katz, Nicholas D Schiff, John Whyte, Eric J Ashman, Stephen Ashwal, Richard Barbano, Flora M Hammond, Steven Laureys, Geoffrey S F Ling, Risa Nakase-Richardson, Ronald T Seel, Stuart Yablon, Thomas S D Getchius, Gary S Gronseth, Melissa J Armstrong
OBJECTIVE: To update the 1995 American Academy of Neurology (AAN) practice parameter on persistent vegetative state and the 2002 case definition for the minimally conscious state (MCS) by reviewing the literature on the diagnosis, natural history, prognosis, and treatment of disorders of consciousness lasting at least 28 days. METHODS: Articles were classified per the AAN evidence-based classification system. Evidence synthesis occurred through a modified Grading of Recommendations Assessment, Development and Evaluation process...
August 8, 2018: Neurology
https://www.readbyqxmd.com/read/30087005/using-human-stem-cells-as-a-model-system-to-understand-the-neural-mechanisms-of-alcohol-use-disorders-current-status-and-outlook
#17
REVIEW
Matthew S Scarnati, Apoorva Halikere, Zhiping P Pang
Alcohol use disorders (AUDs), which include alcohol abuse and dependence, are among the most common types of neuropsychiatric disorders in the United States (U.S.). Approximately 14% of the U.S. population is affected in a single year, thus placing a tremendous burden on individuals from all socioeconomic backgrounds. Animal models have been pivotal in revealing the basic mechanisms of how alcohol impacts neuronal function, yet there are currently limited effective therapies developed based on these studies...
March 31, 2018: Alcohol
https://www.readbyqxmd.com/read/30084809/stem-cell-therapy-for-lung-diseases-from-fundamental-aspects-to-clinical-applications
#18
Hossein Hosseinirad, Mohsen Rashidi, Mehrdad Moosazadeh Moghaddam, Hamid Tebyanian, Soheila Nouraei, Seyed Ali Mirhosseini, Mehdi Rasouli, Soheil Habibian
The respiratory system is a complex group of organs in the human body, all of which are necessary in breathing. Due to its special anatomy and composition, after exposure to various damaging factors such as micro particles, carbon granules and toxic gases, the respiratory system can be affected by a variety of damage without return to its original state. Currently, the prevalence of lung diseases, including asthma, and chronic obstructive pulmonary diseases, such as emphysema, has increased remarkably. New therapeutic approaches are desperately needed to discover regenerative medicine approaches, especially cell therapy...
July 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/30081897/curriculum-mapping-as-a-tool-to-facilitate-curriculum-development-a-new-school-of-medicine-experience
#19
Ghaith Al-Eyd, Francis Achike, Mukesh Agarwal, Hani Atamna, Dhammika N Atapattu, Lony Castro, John Estrada, Rajunor Ettarh, Sherif Hassan, Shaheen E Lakhan, Fauzia Nausheen, Tsugio Seki, Matthew Stegeman, Robert Suskind, Anvar Velji, Mohsin Yakub, Alfred Tenore
BACKGROUND: Every curriculum needs to be reviewed, implemented and evaluated; it must also comply with the regulatory standards. This report demonstrates the value of curriculum mapping (CM), which shows the spatial relationships of a curriculum, in developing and managing an integrated medical curriculum. METHODS: A new medical school developed a clinical presentation driven integrated curriculum that incorporates the active-learning pedagogical practices of many educational institutions worldwide while adhering to the mandated requirements of the accreditation bodies...
August 6, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/30081442/where-are-you-going-nephrology-considerations-on-models-of-care-in-an-evolving-discipline
#20
Giorgina Barbara Piccoli, Conrad Breuer, Gianfranca Cabiddu, Angelo Testa, Christelle Jadeau, Giuliano Brunori
Nephrology is a complex discipline, including care of kidney disease, dialysis, and transplantation. While in Europe, about 1:10 individuals is affected by chronic kidney disease (CKD), 1:1000 lives thanks to dialysis or transplantation, whose costs are as high as 2% of all the health care budget. Nephrology has important links with surgery, bioethics, cardiovascular and internal medicine, and is, not surprisingly, in a delicate balance between specialization and comprehensiveness, development and consolidation, cost constraints, and competition with internal medicine and other specialties...
August 3, 2018: Journal of Clinical Medicine
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