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3D morphology evaluation

T Tatarchuk, O Yefimenko, O Zanko, M Schavinskaya
The aim of the study is to improve the diagnostic approach in assessing the state of the endometrium with the help of ultrasonic endometrial diagnostics in accordance with the IETА criteria in combination with three-dimensional Doppler indices, calculating the volume of the endometrium, and the 3D reconstruction in postmenopausal women. 167 postmenopausal women underwent a 2D pelvic ultrasound examination and a combined three-dimensional complex pelvic ultrasound examination that included calculation of the volume of the endometrium, three-dimensional dopplerometric indices (vascularization index, blood flow index and vascularization ratio), and 3D-reconstruction mode...
October 2018: Georgian Medical News
Mehran Mirramezani, Scott Diamond, Harold Litt, Shawn C Shadden
The efficacy of reduced order modeling for transstenotic pressure drop in the coronary arteries is presented. Coronary artery disease is a leading cause of death worldwide and the computation of fractional flow reserve from computed tomography (FFRct) has become a standard for evaluating the functional significance of a coronary stenosis. FFRct uses 3D computational fluid dynamics to simulate coronary blood flow in order to compute transstenotic pressure drop during simulated hyperemia. In this study, we evaluate different fidelity hydrodynamic models and their ability to compute transstenotic pressure drop and FFRct in the coronary arteries...
December 5, 2018: Journal of Biomechanical Engineering
Takashi Kijima, Hiroshi Nakagawa, Masataka Shimonosono, Prasanna M Chandramouleeswaran, Takeo Hara, Varun Sahu, Yuta Kasagi, Osamu Kikuchi, Koji Tanaka, Veronique Giroux, Amanda B Muir, Kelly A Whelan, Shinya Ohashi, Seiji Naganuma, Andres J Klein-Szanto, Yoshiaki Shinden, Ken Sasaki, Itaru Omoto, Yoshiaki Kita, Manabu Muto, Adam J Bass, J Alan Diehl, Gregory G Ginsberg, Yuichiro Doki, Masaki Mori, Yasuto Uchikado, Takaaki Arigami, Narayan G Avadhani, Devraj Basu, Anil K Rustgi, Shoji Natsugoe
Background & Aims: Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells ex vivo . We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas...
2019: Cellular and Molecular Gastroenterology and Hepatology
Yunyan Chen, Ding Qu, Rongping Fu, Mengfei Guo, Yue Qin, Jian Guo, Yan Chen
Purpose: A transferrin-modified microemulsion carrying coix seed oil and tripterine (Tf-CT-MEs) was developed for improved tumor-specific accumulation and penetration to enhance cervical cancer treatment. Materials and methods: Tripterine-loaded coix seed oil microemulsion (CT-MEs) was prepared through one-step emulsion method. The morphology, size, and zeta potential of CT-MEs and Tf-CT-MEs were examined by transmission electron microscopy and dynamic light scattering...
2018: International Journal of Nanomedicine
Juan Liu, Ling Ding, Cui He, Dan Chen, Su-Rong Deng, Yuan Li
OBJECTIVE: To develop a new method for evaluating the inhibitory effect of aspirin on platelet by the three-dimensional (3D) morphological parameters. METHODS: The sodium citrate-anticoagulant peripheral blood samples collected from 12 healthy volunteers were divided into 2 groups: group treated with 200 μmol/L acetylsalicylic acid (ASA), and control group. The platelets in the 2 groups were washed and purified. The purified platelets were added into reaction pools modified with type I collagen and induced to activation and aggregation under static condition...
December 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
Ulises A Aregueta-Robles, Penny J Martens, Laura A Poole-Warren, Rylie A Green
Promoting nerve regeneration requires engineering cellular carriers to physically and biochemically support neuronal growth into a long lasting functional tissue. This study systematically evaluated the capacity of a biosynthetic poly(vinyl alcohol) (PVA) hydrogel to support growth and differentiation of co-encapsulated neurons and glia. A significant challenge is to understand the role of the dynamic degradable hydrogel mechanical properties on expression of relevant cellular morphologies and function. It was hypothesised that a carrier with mechanical properties akin to neural tissue will provide glia with conditions to thrive, and that glia in turn will support neuronal survival and development...
November 27, 2018: Acta Biomaterialia
Claudio Iovino, Maurizio Fossarello, Giuseppe Giannaccare, Marco Pellegrini, Mirco Braghiroli, Giuseppe Demarinis, Pietro Emanuele Napoli
PURPOSE: To evaluate the feasibility of 3D anterior segment optical coherence tomography (AS-OCT) for the detection of corneal endothelial features in patients with Fuchs' Endothelial Corneal Dystrophy (FECD). METHODS: Twenty patients with clinical diagnosis of FECD (group A), and 20 control subjects (group B) were enrolled. In all patients a complete ophthalmological examination was performed, including best corrected visual acuity (BCVA), slit lamp examination for subjective grading of FECD and corneal endothelial specular microscopy...
2018: PloS One
Jason C Ho, Michael H Amini, Vahid Entezari, Bong Jae Jun, Bashar Alolabi, Eric T Ricchetti, Joseph P Iannotti
BACKGROUND: The primary objectives of this study were to evaluate the ability of a posteriorly stepped augmented glenoid component, used in patients with primary glenohumeral osteoarthritis with B2 or B3 glenoid morphology, to correct preoperative retroversion and humeral head subluxation and to identify factors associated with radiographic radiolucency and patient-reported clinical outcomes. METHODS: We identified 71 shoulders with B2 or B3 glenoid morphology that underwent anatomic total shoulder arthroplasty with use of a posteriorly stepped augmented glenoid component and with a preoperative 3-dimensional computed tomography (3D-CT) scan and a minimum of 2 years of clinical and radiographic follow-up...
November 21, 2018: Journal of Bone and Joint Surgery. American Volume
Nuria Alegret, Antonio Dominguez-Alfaro, Jose Miguel Gonzalez-Dominguez, Blanca Arnaiz, Unai Cossío, Susanna Bosi, Ester Vázquez, Pedro Ramos-Cabrer, David Mecerreyes, Maurizio Prato
Three-dimensional scaffolds for cellular organization need to enjoy a series of specific properties. On the one hand, the morphology, shape and porosity are critical parameters, and eventually re-lated with the mechanical properties. On the other hand, electrical conductivity is an important asset when dealing with electroactive cells, so it is a desirable property even if the conductivity values are not particularly high. Here, we construct 3D porous and conductive composites, where C8-D1A astrocytic cells were incubated to study their biocompatibility...
November 26, 2018: ACS Applied Materials & Interfaces
L Vojtová, T Zikmund, V Pavliňáková, J Šalplachta, D Kalasová, E Prosecká, J Brtníková, J Žídek, D Pavliňák, J Kaiser
This study presents an X-ray computed nanotomography (nano-CT) based, high-resolution imaging technique. Thanks to a voxel resolution of 540 nm, this novel technique is suitable for observing the 3D morphology of soft biopolymeric scaffolds seeded with stem cells. A sample of highly porous collagen scaffold seeded with contrasted mesenchymal stem cells (MSC) was investigated by using lab-based nano-CT. The whole volume of the sample was analysed without its destruction. To evaluate the potential of nano-CT, a comparison measurement was done using a standard microscopy technique...
November 22, 2018: Journal of Microscopy
Minho Lee, June-Goo Lee, Namkug Kim, Joon Beom Seo, Sang Min Lee
Airway diseases are frequently related to morphological changes that may influence lung physiology. Accurate airway region segmentation may be useful for quantitative evaluation of disease prognosis and therapy efficacy. The information can also be applied to understand the fundamental mechanisms of various lung diseases. We present a hybrid method to automatically segment the airway regions on 3D volume chest computed tomography (CT) scans. This method uses multi-scale filtering and support vector machine (SVM) classification...
November 21, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
Depeng Wang, Shah Fahad, Shah Saud, Muhammad Kamran, Aziz Khan, Mohammad Nauman Khan, Hafiz Mohkum Hammad, Wajid Nasim
Food security is confronted by major threats from crop yield stagnation and global climate change. The benefits of phenotypic plasticity across environments for given crop genotypes are thought to be imperative for high-yielding cropping systems. Given that 3D modeling is increasingly recognized for dissecting crop phenotypic plasticity, it requires an assessment of the potential benefits of architectural adaptation of super rice to different agronomic practices. In this study, we focused on a comprehensive evaluation of the phenotypic plasticity of super rice on the aspects of 3D architectural "reoptimization," photosynthetic productivity, nitrogen economy, and grain yield...
November 12, 2018: Plant Physiology and Biochemistry: PPB
Sameh Hany Emile, Steven D Wexner
BACKGROUND: Three-dimensional (3D) printing has been recognized as a revolutionary technological innovation that has benefitted numerous disciplines, including medicine. The present systematic review aimed to demonstrate the current applications of 3D printing in colorectal surgery along with the limitations and potential future applications of this innovation. METHODS: A PRISMA-compliant systematic literature search of studies that applied 3D printing in colorectal surgery in the period January 1990 through to July 2018 was conducted...
November 20, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Bimin Chen, Xin Cheng, Erik W Dorthe, Yinghua Zhao, Darryl D'Lima, Graeme M Bydder, Sirun Liu, Jiang Du, Ya-Jun Ma
Entheses are regions where tendons and ligaments attach to bone, and are the primary target in seronegative and other diseases of the musculoskeletal (MSK) system. MRI has been widely used for visualizing features of inflammatory and degenerative MSK disease; however, normal tendons and entheses have short transverse relaxation times (T2 ), and show little or no signal with conventional clinical MRI pulse sequences, making it difficult to investigate their MR properties. In this study we examined the normal MR morphology of the cadaveric Achilles tendon and enthesis at 3 T using novel three-dimensional ultrashort echo time (3D UTE) Cones sequences, and at 11...
November 20, 2018: NMR in Biomedicine
Eduardo Félix Martins Santana, Edward Araujo Júnior, Gabriele Tonni, Fabricio Da Silva Costa, Simon Meagher
The study presents a pictorial essay of acrania-exencephaly-anencephaly sequence using two-(2D) and three-dimensional (3D) ultrasonography, documenting the different phenotypic characterization of this rare disease. Normal and abnormal fetuses were evaluated during the first trimester scan. The International Society of Ultrasound in Obstetrics and Gynecology practice guidelines were adopted to standardize first trimester anatomical ultrasound screening. The guidelines outline the importance of systematic fetal head and brain examination including the formation of cranial bones, choroid-plexus and ventricles...
2018: Journal of Ultrasonography
Dawang Li, Ping Li, Yingang Du, Ren Wei
The irregular and uneven residual sections along the length of a corroded steel bar substantially change its mechanical properties and significantly dominate the safety and performance of an existing concrete structure. As a result, it is important to measure the geometry and amount of corrosion of a steel bar in a structure properly to assess the residual bearing capacity and service life of the structure. This paper introduces and compares five different methods for measuring the geometry and amount of corrosion of a steel bar...
November 1, 2018: Journal of Visualized Experiments: JoVE
Nuttaya Pattamapaspong, Thanat Kanthawang, Phruksachat Singsuwan, Witsuta Sansiri, Sukon Prasitwattanaseree, Pasuk Mahakkanukrauh
Morphological changes on the surface of the pelvic bone can be used to estimate the age at death of a person. These features can be visualized using three dimensional computed tomography (3D CT) images. A newly introduced 3D CT technique, cinematic volume rendering, improves visualization of the surface of bones by integrating the effect of light on the images. The aim of this study is to evaluate the efficacy of this 3D CT technique in visualizing features related to age estimation in pelvic bones. Dry pelvic bones of 35 subjects were scanned and then 3D reconstruction of the images was performed using the cinematic rendering technique...
October 25, 2018: Forensic Science International
Christophe Garweg, Stijn De Buck, Bert Vandenberk, Rik Willems, Joris Ector
AIM: 3D Rotational angiography (3DRA) allows for detailed reconstruction of atrial anatomy and is often used in the left atrium to facilitate pulmonary vein isolation. This study aimed to reappraise the anatomy of the right atrium (RA) using 3DRA, specifically looking at Koch's triangle and the cavotricuspid isthmus (CTI) in procedures for atrio-ventricular reentrant tachycardia (AVNRT) and atrial flutter (AFl) ablation. METHODS AND RESULTS: 3DRA was performed in 97 patients undergoing ablation for AVNRT (n = 51) or AFl (n = 46)...
November 16, 2018: Scandinavian Cardiovascular Journal: SCJ
Andreas Lesch, Matthias Schlöegl, Martin Holler, Kristian Bredies, Rudolf Stollberger
PURPOSE: Highly accelerated B <mml:math xmlns:mml=""> <mml:msubsup> <mml:mrow/> <mml:mn>1</mml:mn> <mml:mo>+</mml:mo> </mml:msubsup> </mml:math> -mapping based on the Bloch-Siegert shift to allow 3D acquisitions even within a brief period of a single breath-hold. THEORY AND METHODS: The B <mml:math xmlns:mml=""> <mml:msubsup> <mml:mrow/> <mml:mn>1</mml:mn> <mml:mo>+</mml:mo> </mml:msubsup> </mml:math> dependent Bloch-Siegert phase shift is measured within a highly subsampled 3D-volume and reconstructed using a two-step variational approach, exploiting the different spatial distribution of morphology and B <mml:math xmlns:mml="http://www...
October 12, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Philipp Berg, Livia Radtke, Samuel Vos, Steffen Serowy, Gabor Janiga, Berhard Preim, Oliver Beuing, Sylvia Saalfeld
Three-dimensional shape analysis and imagebased hemodynamic simulations are widely used to assess the individual rupture risk of intracranial aneurysms. However, the quality of those results highly depends on pre-simulative working steps including image reconstruction and segmentation. Within this study, three patient-specific aneurysms were reconstructed using three different voxel sizes (0.1 mm, 0.3 mm, 0.5 mm). Afterwards, 3D segmentations and time-dependent blood flow simulations were carried out to evaluate the impact of the reconstruction size...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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