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3D morphology evaluation

Fei Yu, Xiao Han, Kaijia Zhang, Bingyang Dai, Sheng Shen, Xiang Gao, Huajian Teng, Xingsong Wang, Lan Li, Huangxian Ju, Wei Wang, Junfeng Zhang, Qing Jiang
In this study, we designed a polyvinyl alcohol (PVA)-alginate based hydrogel and evaluated its cytocompatibility and printability. The samples were fabricated by 3D printing using a freeze-thaw process. The scanning electron microscope, material testing machine, rheometer, and cell counting kit-8 assay were used to examine the morphology, mechanical properties, rheological properties, and cytocompatiblity of the scaffolds, respectively. The mechanical strength, cytocompatiblity, crosslinking time, and printability were remarkably improved with the use of PVA...
October 17, 2018: Journal of Biomedical Materials Research. Part A
Akane Ozaki, Takahito Otani, Norio Kitagawa, Kayoko Ogata, Hiroshi Iida, Hiroshi Kojima, Tetsuichiro Inai
Vitamin A, which is found in serum, is known to affect keratinocyte proliferation, epidermal differentiation, and keratinization. In mice, stratified epithelia in the oral cavity, esophagus, and forestomach are keratinized; however, these epithelia are not keratinized in humans. Several studies have reported that three-dimensional (3D) cultures of human keratinocytes in serum-containing medium could form keratinized epithelia. Here, we evaluated the effects of serum on the morphology, expression, and localization of differentiation markers and tight junction proteins, and paracellular permeability in 3D cultures of mouse keratinocytes...
October 17, 2018: Histochemistry and Cell Biology
Valentina Pedoia, Berk Norman, Sarah N Mehany, Matthew D Bucknor, Thomas M Link, Sharmila Majumdar
BACKGROUND: Semiquantitative assessment of MRI plays a central role in musculoskeletal research; however, in the clinical setting MRI reports often tend to be subjective and qualitative. Grading schemes utilized in research are not used because they are extraordinarily time-consuming and unfeasible in clinical practice. PURPOSE: To evaluate the ability of deep-learning models to detect and stage severity of meniscus and patellofemoral cartilage lesions in osteoarthritis and anterior cruciate ligament (ACL) subjects...
October 10, 2018: Journal of Magnetic Resonance Imaging: JMRI
Li Liu, Klaus Siebenrock, Lutz-P Nolte, Guoyan Zheng
Periacetabular osteotomy (PAO) is an effective approach for surgical treatment of hip dysplasia in young adults. However, achieving an optimal acetabular reorientation during PAO is the most critical and challenging step. Routinely, the correct positioning of the acetabular fragment largely depends on the surgeon's experience and is done under fluoroscopy to provide the surgeon with continuous live x-ray guidance. Our developed system starts with a fully automatic detection of the acetabular rim, which allows for quantifying the acetabular 3D morphology with parameters such as acetabular orientation, femoral head extrusion index (EI), lateral center-edge (LCE) angle, and total and regional femoral head coverage (FHC) ratio for computer-assisted diagnosis, planning, and simulation of PAO...
2018: Advances in Experimental Medicine and Biology
Gaurav Inamdar, Valentina Pedoia, Jasmine Rossi-Devries, Michael A Samaan, Thomas M Link, Richard B Souza, Sharmila Majumdar
The goal of this study was to use quantitative MRI analysis to longitudinally observe the relationship between 3D proximal femur shape and hip joint degenerative changes. Forty-six subjects underwent unilateral hip MR imaging at three time points (baseline, 18 and 36 months). 3D shape analysis, hip cartilage T1ρ /T2 relaxation time quantification, and SHOMRI MRI grading were performed at each time point. Subjects were grouped based on KL, SHOMRI, and HOOS pain scores. Associations between these score groupings, time, and longitudinal variation in shape, were analyzed using a generalized estimating equation...
October 9, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Y-H Zhang, G Herlin, I Rouvelas, M Nilsson, L Lundell, T B Brismar
The prognostic values of image-based tumor texture analysis based on computed tomography (CT) and of limiting the segmented tumor volume to metabolically active regions using fludeoxyglucose-positron emission tomography (FDG-PET) were studied in 25 patients with esophageal adenocarcinoma and 11 patients with squamous cell carcinoma. The aims of this study are to describe their CT-image-based texture characteristics before and after neoadjuvant therapy and to evaluate whether limiting the examined tumor volume to metabolically active regions detected with FDG-PET image data would further improve their value...
October 8, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Marco Ostoich, Michol Ghezzo, Georg Umgiesser, Mirco Zambon, Loris Tomiato, Federico Ingegneri, Giuseppe Mezzadri
Microbiological impact is critical in coastal areas where tourism is particularly important for both the local and regional economy. Submarine outfalls are commonly used to enhance the dispersion of treated sewage thus avoiding pollution along the coast. The Venice lagoon (North Italy) has a very sensitive ecosystem, due to the morphological and natural characteristics of the basin and the co-existence of human activities. To preserve the lagoon, the discharge from the treatment plant for urban wastewater collected from the Venezia-Mestre agglomeration, neighbouring areas and local industries (total of 400,000 population equivalent-PE) has been moved from the lagoon to the open Adriatic Sea since November 2013 by means of an approximately 20-km pipeline...
October 6, 2018: Environmental Science and Pollution Research International
S Kauppinen, S S Karhula, J Thevenot, T Ylitalo, L Rieppo, I Kestilä, M Haapea, I Hadjab, M A Finnilä, E Quenneville, M Garon, H K Gahunia, K P H Pritzker, M D Buschmann, S Saarakkala, H J Nieminen
OBJECTIVE: Our aim is to establish methods for quantifying morphometric properties of calcified cartilage (CC) from micro-computed tomography (μCT). Furthermore, we evaluated the feasibility of these methods in investigating relationships between osteoarthritis (OA), tidemark surface morphology and open subchondral channels (OSCCs). METHOD: Samples (n = 15) used in this study were harvested from human lateral tibial plateau (n = 8). Conventional roughness and parameters assessing local 3-dimensional (3D) surface variations were used to quantify the surface morphology of the CC...
October 1, 2018: Osteoarthritis and Cartilage
Naser Mobarra, Masoud Soleimani, Reza Pakzad, Seyed Ehsan Enderami, Parvin Pasalar
Nanofibrous scaffolds are considered as a new strategy for Type 1 diabetes mellitus therapy. We used a hybrid of poly-l-lactic acid (PLLA) and polycaprolactone (PCL) as three-dimensional (3D) culture models for differentiation of human induced pluripotent stem cells (hiPSCs) to beta islet-like cluster cell compared with routine culture (2D). Morphological changes of cells were checked by microscope. mRNA endodermal SOX-17 on day 7 and pancreatic gene markers Pdx1, glucagon and Glut2 were evaluated on day 23 by qPCR...
October 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Diana S Jodeh, Heather Curtis, James J Cray, Jonathan Ford, Summer Decker, S Alex Rottgers
INTRODUCTION: Direct anthropometric and three-dimensional (3D) photogrammetry measurements have been used extensively in cleft/craniofacial surgery to assess morphological changes and surgical outcomes. Craniofacial procedures alter the sagittal projection of periorbital bony prominences. Mulliken described a method of measuring their projection relative to the corneal plane but is impractical in clinical practice. Three-dimensional photogrammetry may offer a solution; however, the cornea is not visualized on this...
October 1, 2018: Journal of Craniofacial Surgery
Kazuto Hoshi, Yuko Fujihara, Hideto Saijo, Kumiko Kurabayashi, Hideyuki Suenaga, Yukiyo Asawa, Satoru Nishizawa, Sanshiro Kanazawa, Sakura Uto, Ryoko Inaki, Mariko Matsuyama, Tomoaki Sakamoto, Makoto Watanabe, Madoka Sugiyama, Kazumichi Yonenaga, Atsuhiko Hikita, Tsuyoshi Takato
Introduction: We have developed an implant-type tissue-engineered cartilage using a poly-l-lactide scaffold. In a clinical study, it was inserted into subcutaneous areas of nasal dorsum in three patients, to correct cleft lip-nose deformity. The aim of this study was to helping evaluation on the efficacy of the regenerative cartilage. Methods: 3D data of nasal shapes were compared between before and after surgery in computed tomography (CT) images. Morphological and qualitative changes of transplants in the body were also evaluated on MRI, for one year...
December 2017: Regenerative Therapy
Zhi Zhou, Qingqiang Yao, Lan Li, Xin Zhang, Bo Wei, Li Yuan, Liming Wang
BACKGROUND The aim of this study was to design and test a novel composite scaffold with antibacterial efficacy for treating bone infections using a three-dimensional (3D) printed poly(ε-caprolactone) (PCL) scaffold coated with polydopamine (PDA) for the adsorption of polylactic acid-glycolic acid (PLGA) microspheres loaded with vancomycin. MATERIAL AND METHODS Vancomycin-loaded PLGA microspheres were produced by the double-emulsion method, and microsphere morphology, drug-loading dosage, encapsulation efficiency, average diameter, and release characteristics were examined...
September 30, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Anh-Vu Do, Kristan S Worthington, Budd A Tucker, Aliasger K Salem
Controlled drug delivery systems have been utilized to enhance the therapeutic effects of many drugs by delivering drugs in a time-dependent and sustained manner. Here, with the aid of 3D printing technology, drug delivery devices were fabricated and tested using a model drug (fluorophore: rhodamine B). Poly(ethylene glycol) dimethacrylate (PEGDMA) devices were fabricated using a two-photon polymerization (TPP) system and rhodamine B was homogenously entrapped inside the polymer matrix during photopolymerization...
September 27, 2018: International Journal of Pharmaceutics
Kaiqiang Ye, Dinghua Liu, Haizhu Kuang, Jiangyu Cai, Weiming Chen, Binbin Sun, Lunguo Xia, Bing Fang, Yosry Morsi, Xiumei Mo
Tissue scaffolds with three-dimensional (3D) nanofibrous biomimetic structures have attracted attention in the field of bone regeneration. In recent years, emerging strategies based on electrospinning technologies have facilitated the preparation of 3D nanofibrous scaffolds. Based on these developments, in this study, 3D scaffolds possessing both nanofibrous morphologies and interconnected pores were fabricated for their potential in bone tissue engineering. By combining homogenizing, freeze-drying, and thermal crosslinking techniques, nano-hydroxyapatite/PLLA/gelatin (nHA/PLA/GEL) 3D nanofibrous scaffolds were prepared using pre-fabricated electrospun nanofibers...
September 20, 2018: Journal of Colloid and Interface Science
Xin Zhang, Tamrakar Karuna, Zhi-Qiang Yao, Chuan-Zhi Duan, Xue-Min Wang, Shun-Ting Jiang, Xi-Feng Li, Jia-He Yin, Xu-Ying He, Shen-Quan Guo, Yun-Chang Chen, Wen-Chao Liu, Ran Li, Hai-Yan Fan
OBJECTIVE: Among clinical and morphological criteria, hemodynamics is the main predictor of aneurysm growth and rupture. This study aimed to identify which hemodynamic parameter in the parent artery could independently predict the rupture of anterior communicating artery (ACoA) aneurysms by using multivariate logistic regression and two-piecewise linear regression models. An additional objective was to look for a more simplified and convenient alternative to the widely used computational fluid dynamics (CFD) techniques to detect wall shear stress (WSS) as a screening tool for predicting the risk of aneurysm rupture during the follow-up of patients who did not undergo embolization or surgery...
September 28, 2018: Journal of Neurosurgery
Chen-Guang Liu, Yu-Ting Zeng, Ranjith Kumar Kankala, Shan-Shan Zhang, Ai-Zheng Chen, Shi-Bin Wang
Some basic requirements of bone tissue engineering include cells derived from bone tissues, three-dimensional (3D) scaffold materials, and osteogenic factors. In this framework, the critical architecture of the scaffolds plays a crucial role to support and assist the adhesion of the cells, and the subsequent tissue repairs. However, numerous traditional methods suffer from certain drawbacks, such as multi-step preparation, poor reproducibility, high complexity, difficulty in controlling the porous architectures, the shape of the scaffolds, and the existence of solvent residue, which limits their applicability...
September 26, 2018: Materials
Yi Liu, Pejhman Ghassemi, Andrew Depkon, Maria Ida Iacono, Jonathan Lin, Gonzalo Mendoza, Jianting Wang, Qinggong Tang, Yu Chen, T Joshua Pfefer
Emerging three-dimensional (3D) printing technology enables the fabrication of optically realistic and morphologically complex tissue-simulating phantoms for the development and evaluation of novel optical imaging products. In this study, we assess the potential to print image-defined neurovascular phantoms with patent channels for contrast-enhanced near-infrared fluorescence (NIRF) imaging. An anatomical map defined from clinical magnetic resonance imaging (MRI) was segmented and processed into files suitable for printing a forebrain vessel network in rectangular and curved-surface biomimetic phantoms...
June 1, 2018: Biomedical Optics Express
Virginie Rampal, Pierre-Yves Rohan, Rebekah Saksik, Philippe Wicart, Wafa Skalli
BACKGROUND: The physical examination and weight-bearing radiography are the two main available methods for assessing the feet and lower limbs. The anatomy and function of these two structures interact with each other. These two assessment methods are affected by subjectivity and projection bias. Low-dose biplanar radiography (LDBR) is now a promising alternative for evaluating the lower limbs in children. At present, however, the foot cannot be assessed using LDBR. The objective of this study was to work towards developing a new method for 3D radiographic analysis of the paediatric foot during weight-bearing, first by determining the reproducibility of landmarks defined by LDBR then by reporting the values of the calculated radiographic parameters...
September 22, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Atilla Gül, Jan P de Gijt, Stephen T H Tjoa, Eppo B Wolvius, Maarten J Koudstaal
OBJECTIVE: To provide a literature overview on mandibular midline distraction (MMD) using three-dimensional (3D) imaging analysis techniques. Regarding different distractor types, the focus was on changes in position and/or morphology of the mandibular condyle and temporomandibular joint (TMJ), skeletal effects, dental effects, soft tissue effects, and biomechanical and masticatory effects, specifically on the mandible and TMJ. METHODS: Studies up to March 27 2017 were included, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines, using Embase, Medline OvidSP, Web-of-science, Scopus, Cochrane, and Google Scholar...
August 31, 2018: Journal of Cranio-maxillo-facial Surgery
David Fällmar, Johan Lilja, Torsten Danfors, Lena Kilander, Victor Iyer, Mark Lubberink, Elna-Marie Larsson, Jens Sörensen
Neuroimaging is a central part of diagnostic work-up of patients with suspected neurodegenerative disease. FDG-PET can reveal pathological changes earlier and more reliably than morphological imaging. Diagnostic accuracy can be improved by constructing 3D SSP Z-score maps, showing patterns of significant deficits. During FDG-PET, the subject receives a moderate but not insignificant dose of ionizing radiation, and a dose reduction with retained image quality is desirable. With lower dose, repeated examinations can become a useful tool for monitoring disease progress and potential effects of disease-modifying interventions...
2018: American Journal of Nuclear Medicine and Molecular Imaging
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