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https://www.readbyqxmd.com/read/27920093/metformin-reduces-glycometabolism-of-papillary-thyroid-carcinoma-in-vitro-and-in-vivo
#1
Chen-Tian Shen, Wei-Jun Wei, Zhong-Ling Qiu, Hong-Jun Song, Xin-Yun Zhang, Zhen-Kui Sun, Quan-Yong Luo
More aggressive thyroid cancer cells show a higher activity of glycometabolism. Targeting cancer cell metabolism has emerged as a novel approach to prevent or treat malignant tumors. Glucose metabolism regulation effect of metformin in papillary thyroid cancer was investigated in the current study. Human papillary thyroid carcinoma (PTC) cell lines BCPAP and KTC1 were used. Cell viability was detected by CCK8 assay. Glucose uptake and relative gene expression were measured in metformin (0-10 mM for 48 h)-treated cells by (18)F-FDG uptake assay and western blotting analysis, respectively...
January 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27903730/network-patterns-associated-with-navigation-behaviors-are-altered-in-aged-nonhuman-primates
#2
James R Engle, Christopher J Machado, Michele R Permenter, Julie A Vogt, Andrew P Maurer, Alicia M Bulleri, Carol A Barnes
: The ability to navigate through space involves complex interactions between multiple brain systems. Although it is clear that spatial navigation is impaired during aging, the networks responsible for these altered behaviors are not well understood. Here, we used a within-subject design and [(18)F]FDG-microPET to capture whole-brain activation patterns in four distinct spatial behaviors from young and aged rhesus macaques: constrained space (CAGE), head-restrained passive locomotion (CHAIR), constrained locomotion in space (TREADMILL), and unconstrained locomotion (WALK)...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27875800/evaluation-of-tspo-pet-imaging-a-marker-of-glial-activation-to-study-the-neuroimmune-footprints-of-morphine-exposure-and-withdrawal
#3
Sylvain Auvity, Sébastien Goutal, Benoît Thézé, Catarina Chaves, Benoît Hosten, Bertrand Kuhnast, Wadad Saba, Raphaël Boisgard, Irène Buvat, Salvatore Cisternino, Nicolas Tournier
INTRODUCTION: A growing area of research suggests that neuroimmunity may impact the pharmacology of opioids. Microglia is a key component of the brain immunity. Preclinical and clinical studies have demonstrated that microglial modulators may improve morphine-induced analgesia and prevent the development of tolerance and dependence. Positron emission tomography (PET) using translocator protein 18kDa (TSPO) radioligand is a clinically validated strategy for the non-invasive detection of microglial activation...
November 8, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27856625/longitudinal-micropet-imaging-of-the-zq175-mouse-model-of-huntington-s-disease-shows-in-vivo-changes-of-molecular-targets-in-the-striatum-and-the-cerebral-cortex
#4
Jenny Häggkvist, Miklós Tóth, Lenke Tari, Katarina Varnäs, Marie Svedberg, Anton Forsberg, Sangram Nag, Celia Dominguez, Ignacio Munoz-Sanjuan, Jonathan Bard, John Wityak, Andrea Varrone, Christer Halldin, Ladislav Mrzljak
RATIONALE: Since the discovery of the HTT gene in 1993, numerous animal models have been developed to study the progression of Huntington's disease, as well as to evaluate potential new therapeutics. In the present study we used small animal positron emission tomography (PET) to characterize the expression of molecular targets in the recently reported HD animal model, the zQ175 mouse model. METHODS: Male heterozygous zQ175 (Htttm1Mfc/190JChdi, CHDI-81003003) and wild type (WT, C57BL/6J) animals were imaged with the dopamine D2-receptor radioligand [(11)C]raclopride, the PDE10A radioligand [(18)F]MNI-659, the dopamine D1-receptor radioligand [(11)C]NNC 112 and the 5-HT2A radioligand [(11)C]MDL 100907 at 6 and 9 months of age...
November 10, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27813707/development-and-preclinical-studies-of-64-cu-nota-pertuzumab-f-ab-2-for-imaging-changes-in-tumor-her2-expression-associated-with-response-to-trastuzumab-by-pet-ct
#5
Karen Lam, Conrad Chan, Raymond M Reilly
We previously reported that microSPECT/CT imaging with (111)In-labeled pertuzumab detected decreased HER2 expression in human breast cancer (BC) xenografts in athymic mice associated with response to treatment with trastuzumab (Herceptin). Our aim was to extend these results to PET/CT by constructing F(ab')2 of pertuzumab modified with NOTA chelators for complexing (64)Cu. The effect of the administered mass (5-200 µg) of (64)Cu-NOTA-pertuzumab F(ab')2 was studied in NOD/SCID mice engrafted with HER2-positive SK-OV-3 human ovarian cancer xenografts...
November 4, 2016: MAbs
https://www.readbyqxmd.com/read/27805057/fluselenamyl-a-novel-benzoselenazole-derivative-for-pet-detection-of-amyloid-plaques-a%C3%AE-in-alzheimer-s-disease
#6
G S M Sundaram, Dhruva D Dhavale, Julie L Prior, Ping Yan, John Cirrito, Nigam P Rath, Richard Laforest, Nigel J Cairns, Jin-Moo Lee, Paul T Kotzbauer, Vijay Sharma
Fluselenamyl (5), a novel planar benzoselenazole shows traits desirable of enabling noninvasive imaging of Aβ pathophysiology in vivo; labeling of both diffuse (an earlier manifestation of neuritic plaques) and fibrillar plaques in Alzheimer's disease (AD) brain sections, and remarkable specificity for mapping Aβ compared with biomarker proteins of other neurodegenerative diseases. Employing AD homogenates, [(18)F]-9, a PET tracer demonstrates superior (2-10 fold higher) binding affinity than approved FDA tracers, while also indicating binding to high affinity site on Aβ plaques...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27789722/preclinical-evaluation-of-18f-psma-1007-a-new-psma-ligand-for-prostate-cancer-imaging
#7
Jens Cardinale, Martin Schäfer, Martina Benešová, Ulrike Bauder-Wüst, Karin Leotta, Matthias Eder, Oliver C Neels, Uwe Haberkorn, Frederik L Giesel, Klaus Kopka
INTRODUCTION: In recent years several radiotracers targeting the prostate-specific membrane antigen (PSMA) have been introduced. Few of those had a high clinical impact for the treatment of patients suffering from prostate cancer. However, the number of fluorine-18 labeled tracers addressing PSMA is still limited. Therefore, we aimed at the development of a radiofluorinated molecule with emphasis on resembling the structure of the therapeutic PSMA-617. METHODS: The non-radioactive reference compound PSMA-1007 and the labeling precursor were built up by solid phase chemistry...
October 27, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27784630/minimally-invasive-biomarkers-of-general-anesthetic-induced-developmental-neurotoxicity
#8
X Zhang, F Liu, W Slikker, C Wang, M G Paule
The association of general anesthesia with developmental neurotoxicity, while nearly impossible to study in pediatric populations, is clearly demonstrable in a variety of animal models from rodents to nonhuman primates. Nearly all general anesthetics tested have been shown to cause abnormal brain cell death in animals when administered during periods of rapid brain growth. The ability to repeatedly assess in the same subjects adverse effects induced by general anesthetics provides significant power to address the time course of important events associated with exposures...
October 23, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27763550/age-and-brain-region-specific-changes-of-glucose-metabolic-disorder-learning-and-memory-dysfunction-in-early-alzheimer-s-disease-assessed-in-app-ps1-transgenic-mice-using-18-f-fdg-pet
#9
Xue-Yuan Li, Wei-Wei Men, Hua Zhu, Jian-Feng Lei, Fu-Xing Zuo, Zhan-Jing Wang, Zhao-Hui Zhu, Xin-Jie Bao, Ren-Zhi Wang
Alzheimer's disease (AD) is a leading cause of dementia worldwide, associated with cognitive deficits and brain glucose metabolic alteration. However, the associations of glucose metabolic changes with cognitive dysfunction are less detailed. Here, we examined the brains of APP/presenilin 1 (PS1) transgenic (Tg) mice aged 2, 3.5, 5 and 8 months using (18)F-labed fluorodeoxyglucose ((18)F-FDG) microPET to assess age- and brain region-specific changes of glucose metabolism. FDG uptake was calculated as a relative standardized uptake value (SUVr)...
October 18, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27730471/monitoring-tumor-response-after-liposomal-doxorubicin-in-combination-with-liposomal-vinorelbine-treatment-using-3-deoxy-3-18-f-fluorothymidine-pet
#10
Chun-Yi Wu, Jo-Hsin Tang, Pei-Chia Chan, Jia-Je Li, Ming-Hsien Lin, Chih-Chieh Shen, Ren-Shyan Liu, Hsin-Ell Wang
PURPOSE: Surgical resection is the standard treatment for localized colorectal cancer, which is the most common type of gastrointestinal cancer. However, over 40 % cases are diagnosed metastasized and apparently inoperable. Systemic chemotherapy provides an alternative to these patients. This study aims to evaluate the therapeutic potential of liposomal doxorubicin (lipoDox) in combination with liposomal vinorelbine (lipoVNB) in a CT-26 colon carcinoma-bearing mouse model. PROCEDURES: The in vitro cytotoxicity of Dox and VNB on CT-26 cancer cells was determined by MTT and colony formation assays...
October 11, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27725882/theranostic-cus-nanoparticles-targeting-folate-receptors-for-pet-image-guided-photothermal-therapy
#11
Min Zhou, Shaoli Song, Jun Zhao, Mei Tian, Chun Li
Copper sulfide nanoparticles (CuS NPs) have been reported as a single-compartment theranostic nanosystem to visualize and treat tumors simultaneously. However, few studies have investigated the in vivo tumor-targeted delivery of this class of nanoparticles. In this study, we introduced a tumor-specific targeting ligand, folic acid (FA), onto the surface of CuS NPs as a model system to demonstrate the feasibility of actively targeted CuS NPs for positron emission tomography (PET) imaging and PET image-guided photothermal therapy (PTT)...
December 14, 2015: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/27698942/optimization-of-early-response-monitoring-and-prediction-of-cancer-antiangiogenesis-therapy-via-noninvasive-pet-molecular-imaging-strategies-of-multifactorial-bioparameters
#12
Xiao Bao, Ming-Wei Wang, Jian-Min Luo, Si-Yang Wang, Yong-Ping Zhang, Ying-Jian Zhang
Objective: Antiangiogenesis therapy (AAT) has provided substantial benefits regarding improved outcomes and survival for suitable patients in clinical settings. Therefore, the early definition of therapeutic effects is urgently needed to guide cancer AAT. We aimed to optimize the early response monitoring and prediction of AAT efficacy, as indicated by the multi-targeted anti-angiogenic drug sunitinib in U87MG tumors, using noninvasive positron emission computed tomography (PET) molecular imaging strategies of multifactorial bioparameters...
2016: Theranostics
https://www.readbyqxmd.com/read/27664396/-18f-jnj42259152-binding-to-phosphodiesterase-pde10a-a-key-regulator-of-medium-spiny-neuron-excitability-is-altered-in-the-presence-of-cyclic-amp
#13
Maarten Ooms, Bala Attili, Sofie Celen, Michel Koole, Alfons Verbruggen, Koen Van Laere, Guy Bormans
Phosphodiesterase 10A (PDE10A) is a key regulator of medium spiny neuron excitability. Therefore, it plays an important role in the regulation of motor, reward and cognitive processes. Despite the interest in PDE10A as a drug and PET imaging target, little is known about the regulation of PDE10A enzymatic activity. This study aimed to further investigate the role of cAMP in the regulation of PDE10A activity and PDE10A PET imaging. Using [(18) F]JNJ42259152 as radioligand, we investigated alterations in PDE10A binding secondary to changes in cAMP levels...
September 24, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27646847/synthesis-and-evaluation-of-18-f-labeled-pyridaben-analogues-for-myocardial-perfusion-imaging-in-mice-rats-and-chinese-mini-swine
#14
Tiantian Mou, Zuoquan Zhao, Linyi You, Yesen Li, Qian Wang, Wei Fang, Jie Lu, Cheng Peng, Xianzhong Zhang
This study reports three novel (18)F-labeled pyridaben analogues for potential myocardial perfusion imaging (MPI). Three precursors and the corresponding nonradioactive compounds were synthesized and characterized. The radiolabeled tracers were obtained by substituting tosyl with (18)F. The total radiosynthesis time of these tracers was 70-90 min. Typical decay-corrected radiochemical yields were 47-58%, with high radiochemical purities (>98%). Tracers were evaluated as MPI agents in vitro, ex vivo and in vivo...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27612194/a-novel-potential-positron-emission-tomography-imaging-agent-for-vesicular-monoamine-transporter-type-2
#15
Zih-Rou Huang, Chia-Ling Tsai, Ya-Yao Huang, Chyng-Yann Shiue, Kai-Yuan Tzen, Ruoh-Fang Yen, Ling-Wei Hsin
In the early 1990s, 9-(+)-11C-dihydrotetrabenazine (9-(+)-11C-DTBZ) was shown to be a useful positron emission tomography (PET) imaging agent for various neurodegenerative disorders. Here, we described the radiosynthesis and evaluation of the 9-(+)-11C-DTBZ analog, 10-(+)-11C-DTBZ, as a vesicular monoamine transporter 2 (VMAT2) imaging agent and compare it with 9-(+)-11C-DTBZ. 10-(+)-11C-DTBZ was obtained by 11C-MeI methylation with its 10 hydroxy precursor in the presence of 5 M NaOH. It had a slightly better average radiochemical yield of 35...
2016: PloS One
https://www.readbyqxmd.com/read/27609787/carbidopa-effect-on-18f-fdopa-uptake-in-insulinoma-from-cell-culture-to-micropet-imaging
#16
Julien Detour, Alice Pierre, Frederic Boisson, Guillaume Kreutter, Thomas Lavaux, Izzie Jacques Namer, Laurence Kessler, David Brasse, Patrice Marchand, Alessio Imperiale
: Patient premedication by carbidopa seems to improve the accuracy of 6-(18)F-fluoro-3,4-dihydroxy-L-phenylalanine ((18)F-FDOPA) positron emission tomography (PET) for insulinoma diagnosis. However, the risk of PET false negative result has been evoked using carbidopa. Consequently, we aim to evaluate the effect of carbidopa on (18)F-FDOPA uptake in insulinoma beta cells and insulinoma xenograft model in mice. METHODS: (18)F-FDOPA in vitro accumulation was assessed in the murine beta cell line RIN-m5F...
September 8, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27602494/extracellular-domain-shedding-influences-specific-tumor-uptake-and-organ-distribution-of-the-egfr-pet-tracer-89zr-imgatuzumab
#17
Martin Pool, Arjan Kol, Marjolijn N Lub-de Hooge, Christian A Gerdes, Steven de Jong, Elisabeth G E de Vries, Anton G T Terwisscha van Scheltinga
Preclinical positron emission tomography (PET) imaging revealed a mismatch between in vivo epidermal growth factor receptor (EGFR) expression and EGFR antibody tracer tumor uptake. Shed EGFR ectodomain (sEGFR), which is present in cancer patient sera, can potentially bind tracer and therefore influence tracer kinetics. To optimize EGFR-PET, we examined the influence of sEGFR levels on tracer kinetics and tumor uptake of EGFR monoclonal antibody 89Zr-imgatuzumab in varying xenograft models. Human cancer cell lines A431 (EGFR overexpressing, epidermoid), A549 and H441 (both EGFR medium expressing, non-small cell lung cancer) were xenografted in mice...
September 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27589334/comparative-evaluation-of-4-and-6-carbon-spacer-conformationally-flexible-tetrahydroisoquinolinyl-benzamide-analogues-for-imaging-the-sigma-2-receptor-status-of-solid-tumors
#18
Iljung Lee, Brian P Lieberman, Shihong Li, Catherine Hou, Mehran Makvandi, Robert H Mach
INTRODUCTION: Nine novel analogues were synthesized including a 6-carbon spacer analogue of ISO-1 (7). They have moderate binding affinity for sigma-2 (σ2) receptors and high selectivity for σ2 receptors relative to sigma-1 (σ1) receptors. METHODS: ([(18)F]7) was synthesized and evaluated as a candidate ligand for positron emission (PET) imaging of the σ2 receptor in tumors. Radioligand [(18)F]7 was radiolabeled with (18)F via displacement of the corresponding mesylate precursor with [(18)F]fluoride...
August 9, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27544483/dissociation-of-metabolic-and-hemodynamic-levodopa-responses-in-the-6-hydroxydopamine-rat-model
#19
Renata P Lerner, Zisis Bimpisidis, Stergiani Agorastos, Sandra Scherrer, Stephen L Dewey, M Angela Cenci, David Eidelberg
Dissociation of vasomotor and metabolic responses to levodopa has been observed in human subjects with Parkinson's disease (PD) studied with PET and in autoradiograms from 6-hydroxydopamine (6-OHDA) rat. In both species, acute levodopa administration was associated with increases in basal ganglia cerebral blood flow (CBF) with concurrent reductions in cerebral metabolic rate (CMR) for glucose in the same brain regions. In this study, we used a novel dual-tracer microPET technique to measure CBF and CMR levodopa responses in the same animal...
December 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27518873/the-effect-of-purification-of-ga-68-labeled-exendin-on-in-vivo-distribution
#20
Maarten Brom, Gerben M Franssen, Lieke Joosten, Martin Gotthardt, Otto C Boerman
BACKGROUND: Ga-labeled radiotracers are increasingly used for PET imaging. During the labeling procedure, formation of (68)Ga-colloid may occur. Upon i.v. injection, (68)Ga-colloid will accumulate rapidly in the liver, spleen, and bone marrow, resulting in reduced target-to-background ratios. In this study, we applied a thin layer chromatography (TLC) method to measure colloid content and we studied the effect of the purification method on the in vivo characteristics of (68)Ga-labeled DOTA-exendin-3...
December 2016: EJNMMI Research
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