keyword
MENU ▼
Read by QxMD icon Read
search

Paediatrics

keyword
https://www.readbyqxmd.com/read/29342279/incidence-and-predictors-of-post-transplant-lymphoproliferative-disease-after-kidney-transplantation-during-adulthood-and-childhood-a-registry-study
#1
Anna Francis, David W Johnson, Armando Teixeira-Pinto, Jonathan C Craig, Germaine Wong
Background: Differences in the epidemiology of post-transplant lymphoproliferative disease (PTLD) between adult and paediatric kidney transplant recipients remain unclear. Methods: Using the Australian and New Zealand Dialysis and Transplant Registry (1963-2015), the cumulative incidences of PTLD in children (age <20 years) and adults were calculated using a competing risk of death model and compared with age-matched population-based data using standardized incidence ratios (SIRs)...
January 12, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29342270/whole-genome-analysis-reveals-the-evolution-and-transmission-of-an-mdr-dh-nap11-106-clostridium-difficile-clone-in-a-paediatric-hospital
#2
Larry K Kociolek, Egon A Ozer, Dale N Gerding, David W Hecht, Sameer J Patel, Alan R Hauser
Background: Clostridium difficile strain DH/NAP11/106, a relatively antibiotic-susceptible strain, is now the most common cause of C. difficile infection (CDI) among adults in the USA. Objectives: To identify mechanisms underlying the evolution and transmission of an MDR DH/NAP11/106 clone. Methods: WGS (Illumina MiSeq), restriction endonuclease analysis (REA) and antibiotic susceptibility testing were performed on 134 C. difficile isolates collected from paediatric patients with CDI over a 2 year period...
January 12, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29341979/wilson-s-disease-in-children-a-position-paper-by-the-european-society-for-paediatric-gastroenterology-hepatology-and-nutrition-committee
#3
Piotr Socha, Wojciech Janczyk, Anil Dhawan, Ulrich Baumann, Lorenzo D'Antiga, Stuart Tanner, Raffaele Iorio, Pietro Vajro, Roderick Houwen, Björn Fischler, Antal Dezsofi, Nedim Hadzic, Loreto Hierro, Jörg Jahnel, Valérie McLin, Valerio Nobili, Francoise Smets, Henkjan J Verkade, Dominique Debray
BACKGROUND: Clinical presentations of Wilson's disease (WD) in childhood ranges from asymptomatic liver disease to cirrhosis or acute liver failure, while neurological and psychiatric symptoms are rare. The basic diagnostic approach includes serum ceruloplasmin and 24h-urinary copper excretion. Final diagnosis of WD can be established using a diagnostic scoring system based on symptoms, biochemical tests assessing copper metabolism and molecular analysis of mutations in the ATP7B gene...
October 26, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29341514/opportunity-costs-in-paediatric-training-the-specialist-registrars-experience
#4
M B O'Neill, T Nabialek, N Kandamany
In the training process, there is a tension between the work life and home life of trainees. This study explored both the personal impact and the opportunity costs of training from the Specialist Paediatric Registrar (SPR) perspective. The survey explored 1) career progression, 2) perceived functional effectiveness at work, 3) psychological impact of hospital based training, and 4) the personal and social cost of training. Fifty-three (71%) SPRs responded of whom 47 (89%)were married or in long term relationships...
August 8, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29341240/a-case-report-and-literature-review-of-autism-and-attention-deficit-hyperactivity-disorder-in-paediatric-chronic-pain
#5
Camilla Wiwe Lipsker, Margareta von Heijne, Sven Bölte, Rikard K Wicksell
Psychiatric disorders are common in paediatric patients with chronic pain, but the overall prevalence of comorbid neurodevelopmental disorders is unclear. We report on a case of severe chronic pain in a child with undiagnosed comorbid autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), where significant improvements in pain and function occurred following methylphenidate medication and parental behavioural training. CONCLUSION: The inclusion of behavioural assessment and screening for neurodevelopmental comorbidity may be essential in addressing complex paediatric chronic pain...
January 17, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29341066/cerebral-near-infrared-spectroscopy-nirs-for-perioperative-monitoring-of-brain-oxygenation-in-children-and-adults
#6
REVIEW
Yun Yu, Kaiying Zhang, Ling Zhang, Huantao Zong, Lingzhong Meng, Ruquan Han
BACKGROUND: Various techniques have been employed for the early detection of perioperative cerebral ischaemia and hypoxia. Cerebral near-infrared spectroscopy (NIRS) is increasingly used in this clinical scenario to monitor brain oxygenation. However, it is unknown whether perioperative cerebral NIRS monitoring and the subsequent treatment strategies are of benefit to patients. OBJECTIVES: To assess the effects of perioperative cerebral NIRS monitoring and corresponding treatment strategies in adults and children, compared with blinded or no cerebral oxygenation monitoring, or cerebral oxygenation monitoring based on non-NIRS technologies, on the detection of cerebral oxygen desaturation events (CDEs), neurological outcomes, non-neurological outcomes and socioeconomic impact (including cost of hospitalization and length of hospital stay)...
January 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29340109/development-of-a-targeted-sequencing-approach-to-identify-prognostic-predictive-and-diagnostic-markers-in-paediatric-solid-tumours
#7
Elisa Izquierdo, Lina Yuan, Sally George, Michael Hubank, Chris Jones, Paula Proszek, Janet Shipley, Susanne A Gatz, Caedyn Stinson, Andrew S Moore, Steven C Clifford, Debbie Hicks, Janet C Lindsey, Rebecca M Hill, Thomas S Jacques, Jane Chalker, Khin Thway, Simon O'Connor, Lynley Marshall, Lucas Moreno, Andrew Pearson, Louis Chesler, Brian A Walker, David Gonzalez De Castro
The implementation of personalised medicine in childhood cancers has been limited by a lack of clinically validated multi-target sequencing approaches specific for paediatric solid tumours. In order to support innovative clinical trials in high-risk patients with unmet need, we have developed a clinically relevant targeted sequencing panel spanning 311 kb and comprising 78 genes involved in childhood cancers. A total of 132 samples were used for the validation of the panel, including Horizon Discovery cell blends (n=4), cell lines (n=15), formalin-fixed paraffin embedded (FFPE, n=83) and fresh frozen tissue (FF, n=30) patient samples...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339161/a-new-genetically-engineered-mouse-model-of-choroid-plexus-carcinoma
#8
Salsabiel El Nagar, Frederique Zindy, Charlotte Moens, Luc Martin, Damien Plassard, Martine F Roussel, Thomas Lamonerie, Nathalie Billon
Choroid plexus carcinomas (CPCs) are highly malignant brain tumours predominantly found in children and associated to poor prognosis. Improved therapy for these cancers would benefit from the generation of animal models. Here we have created a novel mouse CPC model by expressing a stabilised form of c-Myc (MycT58A) and inactivating Trp53 in the choroid plexus of newborn mice. This induced aberrant proliferation of choroid plexus epithelial cells, leading to aggressive tumour development and death within 150 days...
January 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29336507/-learn-ing-what-is-important-to-children-and-young-people-with-intellectual-disabilities-when-they-are-in-hospital
#9
K Oulton, D Sell, F Gibson
BACKGROUND: The need to review health service provision for children and young people (CYP) with disabilities and their families in the United Kingdom has been expressed in multiple reports: the most consistent message being that services need to be tailored to meet their individual needs. Our aim was to understand the hospital-related needs and experiences of CYP with intellectual disabilities. METHOD: An ethnographic study of a neurosciences ward and outpatient department was conducted within a paediatric tertiary hospital setting...
January 16, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29335888/root-lengthening-with-apical-closure-in-two-maxillary-immature-permanent-central-incisors-after-placement-of-mineral-trioxide-aggregate-mta-as-an-apical-plug
#10
F Masmoudi, I Bourmeche, A Sebai, Z Baccouche, F Maatouk
BACKGROUND: Necrosis of permanent immature teeth is a common reason for consultation in paediatric dentistry. Apexification is a therapeutic procedure aiming to create an apical calcified barrier in open apex teeth. CASE REPORT: Two cases are presented in which apexification were completed on immature permanent traumatised incisors using a mineral trioxide aggregate (MTA) plug. FOLLOW-UP: At 2 and 5 years showed apical closure and radicular elongation beyond the MTA plug...
January 15, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29335155/investigating-the-potential-impact-of-dose-banding-for-systemic-anti-cancer-therapy-in-the-paediatric-setting-based-on-pharmacokinetic-evidence
#11
Melanie White-Koning, Caroline Osborne, Angelo Paci, Alan V Boddy, Etienne Chatelut, Gareth J Veal
BACKGROUND: To make systemic anti-cancer therapy (SACT) preparation more practicable, dose-banding approaches are currently being introduced in many clinical centres. The present study aimed to determine the potential impact of using recently developed National Health Service in England (NHSE) dose-banding tables in a paediatric setting. METHODS: Using pharmacokinetic parameters obtained from 385 drug administrations in 352 children aged from 1 month to 18 years, treated with five drugs (dactinomycin, busulfan, carboplatin, cyclophosphamide and etoposide), individual exposures (area under the plasma drug concentration versus time curve; AUC) obtained using doses rounded according to the published NHSE tables were calculated and compared with those obtained by standard dose calculation methods...
January 12, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29335153/-the-sitting-position-during-peripheral-venipunctures-in-young-children-a-practice-to-develop
#12
REVIEW
Anne Dario-Meyer, Sylvie Sangare, Anne Dumas Laussinotte
The children's nurse has several missions including that of caring for the child in a holistic approach, ensuring their physical safety and psychological security. When performing peripheral venipunctures in young children, caregivers must implement strategies to relieve pain and prevent psychological traumas which may generate stress for subsequent care procedures. In a paediatric unit, their observations and analysis have improved children's experience of this invasive procedure, with a need for less restraint...
January 2018: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/29335151/-tools-to-overcome-anxiety-in-paediatric-surgery
#13
Nolwenn Febvre
An association of caregivers carried out several actions to combat children's anxiety in paediatric surgery, including anaesthetic masks to cover in stickers, a tactile application on the operating pathway and a cuddly toy in the recovery room. These tools help children at the moment of being separated from their parents and all along their care pathway. They also encourage caregivers to adjust their practices to improve the care provided to the families.
January 2018: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/29335149/-learning-to-separate-together-the-separation-individuation-group
#14
Gwénäelle Andro
The 'separation-individuation' group is offered to children aged between three and five, in outpatient consultations with a paediatric psychiatrist. It was created following the testimonies of early childhood professionals describing the feeling on the part of parents of being torn from their child, during the first year of school. Open and held on a weekly basis, it is combined with a parents' meeting organised simultaneously. The individualised group tool supports the separation-individuation process when this is particularly painful, for the child and the parents...
January 2018: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/29335050/are-hypomineralized-primary-molars-and-canines-associated-with-molar-incisor-hypomineralization
#15
Maria Jose da Silva Figueiredo Sé, Ana Paula Dias Ribeiro, Lourdes Aparecida Martins Dos Santos-Pinto, Rita de Cassia Loiola Cordeiro, Renata Nunes Cabral, Soraya Coelho Leal
PURPOSE: The purpose of this study was to evaluate the prevalence of and relationship between hypomineralized second primary molars (HSPM) and hypomineralized primary canines (HPC) with molar-incisor hypomineralization (MIH) in 1,963 schoolchildren. METHODS: The European Academy of Paediatric Dentistry (EAPD) criterion was used for scoring HSPM/HPC and MIH. Only children with four permanent first molars and eight incisors were considered in calculating MIH prevalence (n equals 858); for HSPM/HPC prevalence, only children with four primary second molars (n equals 1,590) and four primary canines (<small>n</small> equals 1,442) were considered...
November 1, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/29334688/-guideline-for-the-diagnosis-and-treatment-of-asthma-guideline-of-the-german-respiratory-society-and-the-german-atemwegsliga-in-cooperation-with-the-paediatric-respiratory-society-and-the-austrian-society-of-pneumology
#16
R Buhl, R Bals, X Baur, D Berdel, C-P Criée, M Gappa, A Gillissen, T Greulich, P Haidl, E Hamelmann, P Kardos, K Kenn, L Klimek, S Korn, M Lommatzsch, H Magnussen, T Nicolai, D Nowak, O Pfaar, K F Rabe, J Riedler, T Ritz, K Schultz, A Schuster, T Spindler, C Taube, K Taube, C Vogelmeier, A von Leupold, F Wantke, S Weise, J Wildhaber, H Worth, A Zacharasiewicz
No abstract text is available yet for this article.
December 2017: Pneumologie
https://www.readbyqxmd.com/read/29334510/comparing-peri-operative-complications-of-paediatric-and-adult-anaesthesia-a-retrospective-cohort-study-of-81%C3%A2-267-cases
#17
Andrie C Westerkamp, A Fred de Geus, Bouwe Molenbuur, Peter Meyer, J K Götz Wietasch, Michel M R F Struys, Herman G D Hendriks
BACKGROUND: Comparisons of peri-operative complications associated with paediatric (≤16 years) and adult anaesthesia are poorly available, especially in which cardiac surgery, organ transplantation and neurosurgery are involved. OBJECTIVE: The aim of this study was to evaluate the nature and incidence of peri-operative complications that might be due to anaesthesia and to identify independent risk factors for complications in children and adults, including those undergoing cardiac surgery, organ transplantation and neurosurgery...
January 13, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29334194/enrollment-in-early-phase-clinical-trials-in-pediatric-oncology-the-experience-at-institut-curie
#18
Aurore Surun, Marie-Églantine Dujaric, Isabelle Aerts, Daniel Orbach, Irène Jiménez, Hélène Pacquement, Gudrun Schleiermacher, Franck Bourdeaut, Jean Michon, Jean-Claude K Dupont, François Doz
BACKGROUND: The European Paediatric Regulation was introduced in 2007 to facilitate access to new medicines for children. Our study explored accessibility of early-phase trials in pediatric oncology, in line with the European Paediatric Regulation, to identify the reasons for not inviting patients to participate, parents' refusal, or inclusion failure. PROCEDURE: We conducted a retrospective chart review at Institut Curie, Paris, for all pediatric patients whose cancer progressed despite known effective treatments between July 2010 and December 2013...
January 15, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29333497/work-efficiency-improvement-of-90-after-implementation-of-an-annual-inpatient-blood-products-administration-consent-form
#19
Holly Lindsay, Saleh Bhar, Challice Bonifant, Sarah Sartain, Sarah B Whittle, Youngna Lee-Kim, Mona D Shah
Paediatric haematology, oncology and bone marrow transplant (BMT) patients frequently require transfusion of blood products. Our institution required a new transfusion consent be obtained every admission. The objectives of this project were to: revise inpatient blood products consent form to be valid for 1 year, decrease provider time spent consenting from 15 to <5 min per admission, and improve provider frustration with the consent process. Over 6 months, we determined the average number of hospitalisations requiring transfusions in a random sampling of haematology/oncology/BMT inpatients...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/29333484/approaching-the-third-decade-of-paediatric-palliative-oncology-investigation-historical-progress-and-future-directions
#20
Abby R Rosenberg, Joanne Wolfe
Paediatric palliative care (PPC) endeavours to alleviate the suffering and improve the quality of life of children with serious illnesses and their families. In the past two decades since WHO defined PPC and called for its inclusion in paediatric oncology care, rigorous investigation has provided important insights. For example, the first decade of research focused on end-of-life experiences of the child and the family, underscoring the high prevalence of symptom burden, the barriers to parent-provider concordance with regards to prognosis, as well as the need for bereavement supports...
September 2017: Lancet Child & Adolescent Health
keyword
keyword
1613
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"