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https://www.readbyqxmd.com/read/30120769/quantification-of-in-vivo-gastric-fluid-volume-in-bama-miniature-pigs-in-fasted-state
#1
Hui Guo, Cuncai Wang, Zhen Liu, Huayong Gu, Yuwen Li, Li Zhao, Ranran Hou, Jiajia Zhu, Harvey Ho, Zhihui Hao
Although the study of bioequivalence waivers in humans is already well-established, their application and translation into animals, which are complicated by differences in physiology, have only recently become subjects of interest. The main purpose of this paper is to quantify the liquid volume affecting drug dissolution in pig stomachs. We used magnetic resonance imaging (MRI) to scan 18 Bama miniature pigs weighing 15, 30 or 50 kg. Amira 6.0.1 software was used for 3D image processing. We found that the gastric fluid volume had a linear relationship with the weight of pig (R2 = 0...
August 17, 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/30119200/xanthohumol-induces-apoptosis-via-caspase-activation-regulation-of-bcl-2-and-inhibition-of-pi3k-akt-mtor-kinase-in-human-gastric-cancer-cells
#2
Dongli Guo, Baogui Zhang, Shiqi Liu, Meng Jin
We assessed the effect of xanthohumol (XN) on gastric cancer (GC) in vitro and in vivo. XN reduced the viability of SGC-7901, SNU216, and SNU668 cells, but not GES-1 non-tumorigenic human gastric epithelial cells. XN induced apoptosis in SGC-7901 cells in a concentration-dependent manner by enhancing the numbers of late and early apoptotic cells. XN also downregulated the anti-apoptotic proteins Bcl-XL and Bcl-2 and upregulated the pro-apoptotic proteins Bax, Bid, PARP, and caspase-3. XN induced phosphorylation of PI3K, Akt, and mTOR in SGC7901 cells...
July 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30116972/a-review-of-feeding-intolerance-in-critically-ill-children
#3
Lyvonne N Tume, Frédéric V Valla
Ensuring optimal nutrition is vital in critically ill children and enteral feeding is the main route of delivery in intensive care. Feeding intolerance is the most commonly cited reason amongst pediatric intensive care unit healthcare professionals for stopping or withholding enteral nutrition, yet the definition for this remains inconsistent, nebulous, and entirely arbitrary. Not only does this pose problems clinically, but research in this field frequently uses feeding intolerance as an endpoint and the heterogeneity in this definition makes the comparison of studies difficult and meta-analysis impossible...
August 17, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/30116533/studying-the-effect-of-abdominal-massage-on-the-gastric-residual-volume-in-patients-hospitalized-in-intensive-care-units
#4
Farzad Momenfar, Alireza Abdi, Nader Salari, Ali Soroush, Behzad Hemmatpour
Background: The main problem of hospitalized patients in intensive care units is feeding, and if the patient does not receive the daily caloric intake required to his body, he will have malnutrition and problems related to it. Abdominal massage is a method used to improve digestive function in various studies, but few studies have been conducted in intensive care units, and sometimes, contradictory results have been obtained. Therefore, the present study is conducted with the aim of determining the effect of abdominal massage on the gastric residual volume in patients hospitalized in intensive care units...
2018: Journal of Intensive Care
https://www.readbyqxmd.com/read/30115373/exploitation-of-autochthonous-tuscan-sourdough-yeasts-as-potential-starters
#5
Michela Palla, Monica Agnolucci, Antonella Calzone, Manuela Giovannetti, Raffaella Di Cagno, Marco Gobbetti, Carlo Giuseppe Rizzello, Erica Pontonio
The increasing demand for healthy baked goods boosted studies on sourdough microbiota with beneficial metabolic traits, to be used as potential functional starters. Here, yeast populations of traditional sourdoughs collected from four Tuscan bakeries were investigated. Among 200 isolated strains, 78 were randomly selected and molecularly characterized. Saccharomyces cerevisiae was dominant, representing the only species detected in three out of the four sourdoughs. The fourth one harbored also Kazachstania humilis...
August 6, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/30115264/randomised-controlled-trial-comparing-preoperative-carbohydrate-loading-with-standard-fasting-in-paediatric-anaesthesia
#6
B A Tudor-Drobjewski, P Marhofer, O Kimberger, W D Huber, G Roth, L Triffterer
BACKGROUND: Preoperative fasting is a major cause of perioperative discomfort in paediatric anaesthesia and leads to postoperative insulin resistance, thus potentially enhancing the inflammatory response to surgery. Addressing these problems by preoperative carbohydrate intake has not been a well-defined approach in children. METHODS: We randomised 120 children scheduled for gastroscopy under general anaesthesia to either a control group of standard preoperative fasting or a study group receiving a carbohydrate beverage (PreOp™; Nutricia, Erlangen, Germany)...
September 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/30115263/liberal-fluid-fasting-impact-on-gastric-ph-and-residual-volume-in-healthy-children-undergoing-general-anaesthesia-for-elective-surgery
#7
A R Schmidt, K P Buehler, Ch Both, R Wiener, R Klaghofer, M Hersberger, M Weiss, A Schmitz
BACKGROUND: The paediatric preoperative fasting time of 2 h for clear fluids, as suggested by guidelines, is often exceeded. Shorter preoperative fasting has been proposed to avoid potential outcomes such as dehydration, ketoacidosis, reduced arterial blood pressure, and patient discomfort. The aim of this study was to investigate whether liberal clear fluid intake until premedication significantly reduces actual fasting time and impacts gastric pH and residual volume. METHODS: Children (1-16 yr old, ASA I or II) undergoing elective procedures with general anaesthesia requiring tracheal intubation were randomised for clear fluid intake until premedication with midazolam (liberal) or 2 h fluid fasting (standard)...
September 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/30107246/artepillin-c-drupanin-aromadendrin-4-o-methyl-ether-and-kaempferide-from-brazilian-green-propolis-promote-gastroprotective-action-by-diversified-mode-of-action
#8
Philipe Costa, Marilia O Almeida, Marivane Lemos, Caroline Arruda, Rosana Casoti, Lincon Bordignon Somensi, Thaise Boeing, Marihá Mariott, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Bruna De Paoli Stein, Priscila de Souza, Ana Caroline Dos Santos, Jairo K Bastos, Luísa Mota da Silva, Sérgio Faloni de Andrade
ETHOPHARMACOLOGICAL RELEVANCE: The propolis is extensively used in folk medicine in natura or to prepare pharmaceutical formulations since ancient time to improve health or prevent diseases, among them gastrointestinal disorders. Aiming to contribute in the scientific validation about the popular use of Brazilian Green propolis (BGP) against gastritis and gastric ulcer, this work evaluated the antiulcer potential of isolated compounds from BGP, three prenylated p-coumaric acid derivatives and two flavonoids, respectively named: 3,5 diprenyl-4-hydroxycinnamic acid (artepillin C) (1), 3-prenyl-4-dihydroxycinnamoiloxy cinnamic acid (baccharin) (2), 3-prenyl-4-hydroxycinnamic acid (drupanin) (3), aromadendrin-4'-O-methyl-ether (4) and kaempferide (5)...
August 11, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30106567/high-throughput-breath-volatile-organic-compound-analysis-using-thermal-desorption-proton-transfer-reaction-time-of-flight-mass-spectrometry
#9
Andrea Romano, Sophie Doran, Ilaria Belluomo, George Bushra Hanna
Breath analysis is highly acceptable to patients and health care professionals, but its implementation in clinical practice remains challenging. Clinical trials and routine practice require a robust system for collection, storage, and processing of large numbers of samples. This work describes a platform based upon the hyphenation of thermal desorption (TD) with proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS), coupled by means of an original modification of the TD interface. The performance of TD-PTR-ToF-MS was tested against seven oxygenated volatile organic compounds (VOCs), belonging to three chemical classes (i...
August 14, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/30095551/ultrasound-assessment-of-gastric-emptying-time-after-a-standardised-light-breakfast-in-healthy-children-a-prospective-observational-study
#10
Christiane E Beck, Lars Witt, Lisa Albrecht, Nils Dennhardt, Dietmar Böthig, Robert Sümpelmann
OBJECTIVES: Current guidelines recommend 6 h of fasting for solids before anaesthesia. However, prolonged fasting may lead to discomfort, hunger, thirst, misbehaviour and lipolysis. To prevent this, a more liberal fasting regimen has been empirically implemented in our children's hospital, allowing a shorter fasting time of 4 h for a standardised light breakfast. AIM: The aim of this study was to determine the gastric emptying time after a standardised light breakfast in healthy children...
August 7, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/30094637/assessment-of-the-correlation-between-preoperative-and-immediate-postoperative-gastric-volume-and-weight-loss-after-sleeve-gastrectomy-using-computed-tomography-volumetry
#11
Hosam Elbanna, Sameh Emile, Galal El-Sayed El-Hawary, Noha Abdelsalam, Hossam Abdelhafiz Zaytoun, Haitham Elkaffas, Ahmed Ghanem
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has achieved excellent results in treatment of morbid obesity. The present study aimed to evaluate the impact of the preoperative gastric volume, volume of the remaining gastric pouch, and volume of the resected stomach on weight loss after LSG. METHODS: Patients with morbid obesity who underwent LSG were investigated by CT volumetry before and 1 week after LSG to measure the volume of the stomach before and after the procedure, and the volume of the resected stomach was also calculated...
August 9, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/30094537/locally-advanced-gastric-cancer-total-iodine-uptake-to-predict-the-response-of-primary-lesion-to-neoadjuvant-chemotherapy
#12
Xiaoyuan Gao, Yang Zhang, Fei Yuan, Bei Ding, Qianchen Ma, Wenjie Yang, Jing Yan, Lianjun Du, Baisong Wang, Fuhua Yan, Martin Sedlmair, Zilai Pan, Huan Zhang
PURPOSE: Pathologic response to neoadjuvant chemotherapy is a prognostic factor in many cancer types. However, the existing evaluative criteria are deficient. We sought to prospectively evaluate the total iodine uptake derived from dual-energy computed tomography (DECT) in predicting treatment efficacy and progression-free survival (PFS) time in gastric cancer after neoadjuvant chemotherapy. METHODS: From October 2012 to December 2015, 44 patients with locally advanced gastric cancer were examined with DECT 1 week before and three cycles after neoadjuvant chemotherapy...
August 9, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30091963/preoperative-assessment-of-ultrasonographic-measurement-of-antral-area-for-gastric-content
#13
Ayhan Kaydu, Erhan Gokcek
BACKGROUND Pulmonary aspiration of the gastric contents is a serious perioperative complication. The aim of this study was to evaluate the efficacy of portable ultrasonography in the preoperative evaluation of the gastric contents of patients. The secondary aim was to examine the relationship between gastric antrum cross-sectional area and age and body mass index (BMI). MATERIAL AND METHODS This single-center, prospective, cross-sectional study included 120 patients who underwent surgery. Measurements the gastric antral cross-sectional areas and quantitative and qualitative measurements of the stomach were taken by ultrasonography guidance in all patients...
August 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30090636/feline-gastric-pneumatosis
#14
Carla Silveira, Livia Benigni, Kaye Gugich, Janet Kovak McClaran
Case summary: A 9-year-old male neutered domestic shorthair cat was presented with a 2 day history of anorexia and vomiting. A minimum database, including a complete blood count, serum biochemistry profile and urinalysis were unremarkable apart from a toxic neutrophilic left shift and borderline proteinuria. Abdominal ultrasound revealed intramural gas entrapment with thinning of the gastric wall, a hypoechoic pancreas, peritoneal fluid and a small volume of peritoneal gas along with a hyperechoic mesentery...
July 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/30088543/assessing-gastric-residual-volume-a-description-of-nurses-clinical-practice
#15
Vanessa de Brito Poveda, Ana Carolina Breviglieri Alves Castilho, Lilia de Souza Nogueira, Renata Eloah Lucena Ferretti-Rebustini, Rita de Cássia Gengo E Silva
OBJECTIVE: To analyze the differences in nurses' clinical practice for assessing residual gastric volume and identifying the theoretical framework which supports their practice. METHOD: A cross-sectional study carried out by sending an online questionnaire by e-mail to nurses registered at the Regional Nursing Council of the State of São Paulo. RESULTS: This study included 598 nursing professionals, with 484 only providing care to adults and 114 exclusively to children...
August 6, 2018: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/30087071/cytoreductive-surgery-combined-with-hyperthermic-intraperitoneal-chemotherapy-hipec-in-patients-with-gastric-cancer-and-peritoneal-carcinomatosis
#16
Cristina Rihuete Caro, Israel Manzanedo, Fernando Pereira, Lucía Carrion-Alvarez, Ángel Serrano, Estíbalitz Pérez-Viejo
BACKGROUND: Gastric Cancer (GC) with Peritoneal Carcinomatosis (PC) has long been regarded as a terminal disease. Over the past two decades, cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has changed the traditional concept of peritoneal metastases from being a systemic disease, to being considered a locoregional dissemination. PATIENTS AND METHODS: A prospective study was performed at a high-volume Carcinomatosis Center to evaluate survival, morbi-mortality and prognostic factors for survival in a cohort of patients with GC and PC treated with CRS + HIPEC between June 2006 and December 2016...
July 26, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30084204/prevalence-and-prediction-of-higher-estimated-gastric-content-in-parturients-at-full-cervical-dilatation-a-prospective-cohort-study
#17
François-Pierrick Desgranges, Marine Simonin, Sophie Barnoud, Laurent Zieleskiewicz, Eloise Cercueil, Julien Erbacher, Bernard Allaouchiche, Dominique Chassard, Lionel Bouvet
BACKGROUND: Emergent obstetrical procedures may require general anaesthesia in parturients at full cervical dilatation or immediately after vaginal birth. This study aimed to determine the prevalence and the predictive factors of higher estimated gastric content in parturients at full cervical dilatation with epidural analgesia and allowed to drink during the labour, and to assess the ability of the antral area measured in the semirecumbent position (SR-CSA) to identify higher estimated gastric content in this setting...
August 7, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/30082543/radical-gastrectomy-for-gastric-cancer-at-tata-memorial-hospital
#18
Manish S Bhandare, Naveena Kumar An, Swati Batra, Vikram Chaudhari, Shailesh V Shrikh
AIM: Tata Memorial Hospital is one of the high-volume tertiary care referral centers for gastric cancer (GC) in India. We aimed to analyze the outcomes after surgery for GC. PATIENTS AND METHODS: Data were collected from the prospective database maintained by the Gastrointestinal and Hepato-Pancreato-Biliary Division of the Department of Surgical Oncology at Tata Memorial Hospital, Mumbai, Maharashtra, India. All consecutive patients who underwent curative resection for adenocarcinoma of the stomach from January 2010 to December 2015 were included...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30081206/echinochrome-pigment-as-novel-therapeutic-agent-against-experimentally-induced-gastric-ulcer-in-rats
#19
Dawlat A Sayed, Amel M Soliman, Sohair R Fahmy
OBJECTIVE: evaluate the antiulcer healing effect of echinochrome pigment (Ech 5 and 10 mg/kg) extracted from sea urchin (Paracentrotus lividus). METHODS: Severe gastric ulceration induced in rats by administration of indomethacin in combination with cold stress (IND + CS) for 2 h. The antiulcer effect of Ech was indicated by determination of gastric juice volume, gastric juice acidity, and ulcer index as well as determination of gastric malondialdhyde (MDA), glutathione (GSH), catalase (CAT), glutathione-S-transferase (GST), superoxide dismutase (SOD), nitric oxide (NO) activities...
August 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30078305/evaluation-of-gastric-disease-with-capsule-endoscopy
#20
Seung-Joo Nam, Hyun Seok Lee, Yun Jeong Lim
The clinical indication for capsule endoscopy has expanded from small bowel evaluation to include esophagus or colon evaluation.Nevertheless, the role of capsule endoscopy in evaluation of the stomach is very limited because of the large volume and surface.However, efforts to develop an active locomotion system for capsule manipulation in detailed gastric evaluation are ongoing, becausethe technique is non-invasive, convenient, and safe, and requires no sedation. Studies have successfully reported gastric evaluation usinga magnetic-controlled capsule endoscopy system...
July 2018: Clinical Endoscopy
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