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https://www.readbyqxmd.com/read/30323564/gastric-cancer-combination-therapy-synthesis-of-a-hyaluronic-acid-and-cisplatin-containing-lipid-prodrug-coloaded-with-sorafenib-in-a-nanoparticulate-system-to-exhibit-enhanced-anticancer-efficacy-and-reduced-toxicity
#1
Feng Yang, Aimei Li, Han Liu, Hairong Zhang
Purpose: Gastric cancer is one of the most common human epithelial malignancies, and using nanoparticles (NPs) in the diagnosis and treatment of cancer has been extensively studied. The aim of this study was to develop hyaluronic acid (HA) containing lipid NPs coloaded with cisplatin (CDDP) and sorafenib (SRF) for the treatment of gastric cancer. Materials and methods: HA and CDDP containing lipid prodrug was synthesized using polyethylene glycol (PEG) as a linker (HA-PEG-CDDP)...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/30318663/weight-improvement-with-the-use-of-protein-and-energy-enriched-nutritional-formula-in-infants-with-a-prolonged-picu-stay
#2
R D Eveleens, D K Dungen, S C A T Verbruggen, J M Hulst, K F M Joosten
BACKGROUND: Reaching an optimal nutritional intake is challenging in critically ill infants. One possible way to minimise nutritional deficits is the use of protein and energy-enriched (PE)-formulas. We aimed to describe weight achievement and gastrointestinal symptoms in infants admitted to the paediatric intensive care unit (PICU) while receiving PE-formula for a prolonged period. METHODS: Records from infants admitted to a multidisciplinary PICU and using PE-formula were analysed retrospectively...
October 14, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/30302654/effect-of-hospital-and-surgeon-volume-on-postoperative-outcomes-after-distal-gastrectomy-for-gastric-cancer-based-on-data-from-145-523-japanese-patients-collected-from-a-nationwide-web-based-data-entry-system
#3
Masaaki Iwatsuki, Hiroyuki Yamamoto, Hiroaki Miyata, Yoshihiro Kakeji, Kazuhiro Yoshida, Hiroyuki Konno, Yasuyuki Seto, Hideo Baba
BACKGROUND: Despite interest in surgeon and hospital volume effects on distal gastrectomy, clinical significance has not been confirmed in a large-scale population. We studied to clarify the effects of surgeon and hospital volume on postoperative mortality after distal gastrectomy for gastric cancer among Japanese patients in a nationwide web-based data entry system. METHODS: We extracted data on distal gastrectomy for gastric cancer from the National Clinical Database between 2011 and 2015...
October 9, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/30298517/anti-alcohol-liver-disease-effect-of-gentianae-macrophyllae-extract-through-mapk-jnk-p38-pathway
#4
Yulei Cui, Lei Jiang, Yun Shao, Lijuan Mei, Yanduo Tao
OBJECTIVES: The hepatoprotective effect of Gentianae macrophyllae root extract (GME) on alcoholic liver disease (ALD) was evaluated through ethanol induced ALD animal model. METHODS: Mice were randomly divided into control normal group (10 mice), ethanol-induced ALD model group (10 mice) and GME plus ethanol group (30 mice). Mice in model group were given intragastric administration with 50% (v/v) ethanol aqueous solution (200 μl for each) once daily for 19 days...
October 9, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/30294835/pathophysiology-and-treatment-of-gastrointestinal-motility-disorders-in-the-acutely-ill
#5
REVIEW
Adam M Deane, Marianne J Chapman, Annika Reintam Blaser, Stephen A McClave, Anton Emmanuel
Gastrointestinal dysmotility causes delayed gastric emptying, enteral feed intolerance, and functional obstruction of the small and large intestine, the latter functional obstructions being frequently termed ileus and Ogilvie syndrome, respectively. In addition to meticulous supportive care, drug therapy may be appropriate in certain situations. There is, however, considerable variation among individuals regarding what gastric residual volume identifies gastric dysmotility and would encourage use of a promotility drug...
October 7, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/30292279/ct-texture-analysis-can-be-a-potential-tool-to-differentiate-gastrointestinal-stromal-tumors-without-kit-exon-11-mutation
#6
Fei Xu, Xiaohong Ma, Yichen Wang, Yuan Tian, Wei Tang, Meng Wang, Ren Wei, Xinming Zhao
OBJECTIVE: To evaluate CT texture analysis as a tool to differentiate gastrointestinal stromal tumors (GISTs) without KIT exon 11 mutation. MATERIALS AND METHODS: This study consisted of a study group of 69 GISTs and a validation group of 17 GISTs. Clinical information of the patients were collected and analyzed. Two-dimensional and three-dimensional texture analysis was performed. The textural parameters were evaluated in the study group and were validated in the validation group...
October 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/30292000/incidence-of-postoperative-nausea-and-vomiting-after-laparoscopic-sleeve-gastrectomy-with-staple-line-reinforcement-with-oversewing-and-staple-line-inversion-vs-buttressing-material-a-randomized-clinical-trial
#7
Jaime Ruiz-Tovar, Lorea Zubiaga, Jose Luis Muñoz, Carolina Llavero
BACKGROUND: Postoperative nausea and vomiting are relevant complications after restrictive bariatric procedures, such as sleeve gastrectomy, mainly secondary to a drastic reduction in the gastric volume. However, other causes can be involved. The aim of this study was to determine the incidence of postoperative nausea and vomiting (PONV) after laparoscopic sleeve gastrectomy (LSG), with staple line reinforcement with oversewing vs buttressing material. PATIENTS AND METHODS: A prospective randomized clinical trial of all the patients undergoing LSG was performed...
October 3, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/30290991/roux-en-y-gastric-bypass-versus-sleeve-gastrectomy-what-factors-influence-patient-preference
#8
Kara J Kallies, Luis D Ramirez, Brandon T Grover, Shanu N Kothari
BACKGROUND: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are the most commonly performed bariatric procedures. RYGB involves altered gastrointestinal anatomy and 2 anastomoses, while SG involves gastric resection. When potential patients view images of the procedures, they may perceive RYGB to involve significant risk compared with SG, in which no significant gastrointestinal alterations are depicted. OBJECTIVE: To evaluate preferences for RYGB versus SG...
September 4, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/30288113/computed-tomography-scan-efficacy-in-staging-gastric-linitis-plastica-lesion-a-retrospective-multicentric-french-study
#9
Stéphanie Morgant, Pascal Artru, Ammar Oudjit, Nelson Lourenco, Arnaud Pasquer, Thomas Walter, Jean-Marc Gornet, Alexandre Rouquette, Gérard Lledo, Catherine Brezault, Romain Coriat
Background: Computed tomography (CT) scan is a key imaging technique in the staging of gastric adenocarcinoma and therapeutic management of patients. The aim of this study was to evaluate the performance of CT scan in the staging of parietal and metastatic invasion in gastric linitis plastica group. Methods: A retrospective multicentric French study was conducted from January 2006 to December 2015 on patients with no metastatic gastric linitis plastica and operated by gastrec-tomy...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30288059/plk1-as-a-potential-prognostic-marker-of-gastric-cancer-through-mek-erk-pathway-on-pdtx-models
#10
Sheng-Chun Dang, Yi-Yi Fan, Lei Cui, Ji-Xiang Chen, Jian-Guo Qu, Min Gu
Background: PLK1 has been identified as having a great effect on cell division and maintaining genomic stability in mitosis, spindle assembly, and DNA damage response by current studies. Materials and methods: We assessed PLK1 expression in cervical cancer tissues and cells. We have also evaluated the effects of PLK1 on gastric cancer cell proliferation, migration, and apoptosis both in vitro and in vivo. Results: Our results show that PLK1 is overexpressed in gastric cancer tissues and cells...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/30276005/safety-of-laparoscopic-radical-gastrectomy-in-gastric-cancer-patients-with-end-stage-renal-disease
#11
Hayemin Lee, Cho Hyun Park, Seung Man Park, Wook Kim, Hyung Min Chin, Jin Jo Kim, Kyo Young Song, Sung Geun Kim, Kyong Hwa Jun, Jeong Goo Kim, Han Hong Lee, Junhyun Lee, Dong Jin Kim
Purpose: The surgical outcomes of end-stage renal disease (ESRD) patients undergoing radical gastrectomy for gastric cancer were inferior compared with those of non-ESRD patients. This study aimed to evaluate the short- and long-term surgical outcomes of ESRD patients undergoing laparoscopic gastrectomy (LG) and open gastrectomy (OG) for gastric cancer. Materials and Methods: Between 2004 and 2014, 38 patients (OG: 21 patients, LG: 17 patients) with ESRD underwent gastrectomy for gastric cancer...
September 2018: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/30275208/-roux-en-y-plus-distal-jejunal-pouch-after-total-gastrectomy-a-prospective-study
#12
Sumiya Ishigami, Kuniaki Aridome, Takaaki Arigami, Yoshikazu Uenosono, Hiroshi Okumura, Yoshiaki Kita, Hiroshi Kurahara, Shuichi Hokita, Shoji Natsugoe
BACKGROUND/AIM: We previously described the safety of distal jejunal pouch with Roux-en-Y reconstruction after total gastrectomy. The present prospective study evaluated its clinical benefit. PATIENTS AND METHODS: Forty-five patients with gastric cancer were preoperatively assigned to groups who underwent Roux-en-Y reconstruction with jejunal pouch (PRY) (n=23) or without pouch (RY) (n=22). Age, sex, grade of lymph node dissection, splenectomy and mode of laparotomy were analyzed, and body mass index (BMI), volume of food intake at one sitting and blood chemistry (total protein, hemoglobin, iron and cholesterol) were periodically assessed in both groups...
October 2018: Anticancer Research
https://www.readbyqxmd.com/read/30272844/safety-and-benefit-of-pre-operative-oral-carbohydrate-in-infants-a-multi-center-study-in-china
#13
Weiwei Jiang, Xiang Liu, Fengli Liu, Shungen Huang, Jie Yuan, Yingzuo Shi, Huan Chen, Jie Zhang, Changgui Lu, Wei Li, Qiming Geng, Xiaoqun Xu, Weibing Tang
BACKGROUND AND OBJECTIVES: Pre-operative oral carbohydrate administration (POCA) is an important aspect of enhanced recovery after surgery and has many advantages. The objective of this study was to explore the safety and effect of pre-operative oral carbohydrate administration in infants. METHODS AND STUDY DESIGN: This was a prospective, multi-center, randomized study that randomly assigned 1200 infants into four groups. In the control group (group A), the infants were strictly restricted to 6-h preoperative fasting before anesthesia...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30270047/effect-of-preemptive-acetaminophen-administered-within-1-hour-of-general-anesthesia-on-gastric-residual-volume-and-ph-in-children
#14
Constance N Burke, Rebecca D'Agostino, Alan R Tait, Shobha Malviya, Terri Voepel-Lewis
PURPOSE: Determine whether preoperative oral acetaminophen increases gastric residual volume and lowers gastric pH. DESIGN: Prospective, randomized. METHODS: Healthy children, 1 to 14 years, having elective magnetic resonance imaging (MRI) were randomized to oral acetaminophen within 1 hour of induction versus fasting. Gastric volume and pH were measured immediately after intubation. Adverse events were documented from induction through 72 hours post MRI...
September 27, 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/30269323/-application-of-gastric-tube-esophagoplasty-to-complicated-diseases-of-esophagus-in-children
#15
Jiahang Zeng, Wei Liu, Jianhua Liang, Fenghua Wang, Hui Wang, Jue Tang
OBJECTIVE: To summarize the experience of applying gastric tube esophagoplasty for complicated diseases of esophagus in children and the short-middle-term efficacy. METHODS: A retrospective and observational case series study was performed. INCLUSION CRITERIA: (1) burn length of esophagus > 2 cm, multisegmental or extensive esophageal scar stenosis, and about 6 months after burn; (2) longitudinal diameter of esophageal tumor > 2 cm, or esophagus considered as impossible to reserve;(3) Severe esophageal fistula with diameter > 2 cm, or relapse again after ≥3 times of repair; (4) Tracheal cartilaginous esophageal heterotopia with a length of >2 cm or no end to end anastomosis after removal of the esophageal lesion...
September 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/30269319/-impact-of-gastric-tube-diameter-on-quality-of-life-of-esophagus-cancer-patient-after-ivor-lewis-esophagectomy
#16
Xiaofeng He, Minke Shi, Bin Cao
OBJECTIVE: To explore the impact of the gastric tube diameter on quality of life of esophagus cancer patients after Ivor-Lewis esophagectomy. METHODS: Clinical and follow-up data of 188 esophageal cancer patients who underwent Ivor-Lewis esophagectomy at Department of Cardio-Thoracic Surgery, Drum Tower Clinical Medicine College, Nanjing Medical University from January 2015 to June 2016 were retrospectively analyzed. Inclusion criteria included age <75 years old, good foundation health situation, no distant metastasis, complete follow-up data for one-year after surgery, and middle-lower esophageal squamous cell carcinoma (ESCC)...
September 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/30261711/currently-available-non-balloon-devices
#17
Hang Lak Lee
Obesity and metabolic syndrome are known to have an impact on the economy. Obesity and metabolic syndrome affect about 40% population in the America alone, and with about 400 million obese adults in the world, obesity is a global concern. Moreover, the prevalence of overweight children is increasing. Bariatric surgery remains the gold standard for the treatment of obesity; however, endoscopic approaches may have a significant role in the management of metabolic syndrome and obesity. Until recently, many endoscopic methods have been introduced; however, few methods are used in practice, whereas others are under experimental research...
September 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/30259158/eus-guided-fine-needle-injection-is-superior-to-direct-endoscopic-injection-of-2-octyl-cyanoacrylate-for-the-treatment-of-gastric-variceal-bleeding
#18
Benjamin L Bick, Mohammad Al-Haddad, Suthat Liangpunsakul, Marwan S Ghabril, John M DeWitt
BACKGROUND: Endoscopic injection of cyanoacrylate into gastric varices may be performed by EUS-guided fine needle injection (EUS-FNI) or direct endoscopic injection (DEI). The aim of this study is to compare the rate of recurrent GV bleeding and adverse events between DEI and EUS-FNI for treatment of GV. METHODS: In a single-center study, a retrospective cohort of patients with actively/recently bleeding or high-risk GV treated with DEI were compared with a prospective cohort of similar patients treated with EUS-FNI...
September 26, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30256164/minimally-invasive-versus-open-pancreaticoduodenectomy-an-up-to-date-meta-analysis-of-comparative-cohort-studies
#19
Yunxiao Lyu, Yunxiao Cheng, Bin Wang, Yueming Xu, Weibing Du
BACKGROUND: This systematic review and meta-analysis were performed to summarize available evidence comparing totally minimally invasive pancreaticoduodenectomy (TMIPD) versus open pancreaticoduodenectomy (OPD) Materials and Methods: We searched PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov for comparative cohort studies published from January 1990 through April 2018 comparing TMIPD versus OPD. Outcomes evaluated were postoperative pancreatic fistula (POPF), delayed gastric emptying (DGE), postoperative hemorrhage, wound infection, estimated blood loss, transfusion rate, retrieved lymph nodes (RLNs), R0 rate, reoperation rate, length of hospital stay, and mortality...
September 25, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/30254439/lipid-insertion-enables-targeted-functionalization-of-paclitaxel-loaded-erythrocyte-membrane-nanosystem-by-tumor-penetrating-bispecific-recombinant-protein
#20
Hong Chen, Huizi Sha, Lianru Zhang, Hanqing Qian, Fangjun Chen, Naiqin Ding, Liulian Ji, Anqing Zhu, Qiuping Xu, Fanyan Meng, Lixia Yu, Yan Zhou, Baorui Liu
Background: There is currently much interest in cancer cell targeting and tumor penetrating for research and therapeutic purposes. Purpose: To improve targeting delivery of antitumor drugs to gastric cancer, in this study, a tumor-targeting biocompatible drug delivery system derived from erythrocyte membrane for delivering paclitaxel (PTX) was constructed. Methods: Erythrocyte membrane of human red blood cells (RBCs) were used for preparing of erythrocyte membrane-derived vesicles...
2018: International Journal of Nanomedicine
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