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Atrial fibrilation anemia

Luke K Kim, Ilhwan Yeo, Jim W Cheung, Rajesh V Swaminathan, S Chiu Wong, Konstantinos Charitakis, Oluwayemisi Adejumo, John Chae, Robert M Minutello, Geoffrey Bergman, Harsimran Singh, Dmitriy N Feldman
Background Readmission after ST-segment-elevation myocardial infarction ( STEMI ) poses an enormous economic burden to the US healthcare system. Efforts to prevent readmissions should be based on understanding the timing and causes of these readmissions. This study aimed to investigate contemporary causes, timing, and cost of 30-day readmissions after STEMI . Methods and Results All STEMI hospitalizations were selected in the Nationwide Readmissions Database ( NRD ) from 2010 to 2014. The 30-day readmission rate as well as the primary cause and cost of readmission were examined...
September 18, 2018: Journal of the American Heart Association
Amer N Kadri, Hasan Abuamsha, Leen Nusairat, Nazih Kadri, Hussam Abuissa, Ahmad Masri, Adrian V Hernandez
Background Syncope accounts for 0.6% to 1.5% of hospitalizations in the United States. We sought to determine the causes and predictors of 30-day readmission in patients with syncope. Methods and Results We identified 323 250 encounters with a primary diagnosis of syncope/collapse in the 2013-2014 Nationwide Readmissions Database. We excluded patients younger than 18 years, those discharged in December, those who died during hospitalization, hospital transfers, and those whose length of stay was missing. We used multivariable logistic regression analysis to evaluate the association between baseline characteristics and 30-day readmission...
September 18, 2018: Journal of the American Heart Association
Tomo Ando, Oluwole Adegbala, Pedro Villablanca, Emmanuel Akintoye, Said Ashraf, Mohamed Shokr, Alexandros Briasoulis, Hisato Takagi, Cindy L Grines, Luis Afonso, Theodore Schreiber
Candidates for transcatheter aortic valve implantation (TAVI) are generally older with multiple co-morbidities and are therefore susceptible to nonelective admissions before scheduled TAVI. Frequency, predictors, and outcomes of TAVI after nonelective admission are under-explored. We queried the Nationwide Inpatient Sample database, an administrative database, from January 2012 to September 2015 to identify hospitalization in those age ≥50 who had transarterial TAVI. A propensity-matched cohort was created to compare the outcomes between nonelective and elective admission who had TAVI...
September 26, 2018: American Journal of Cardiology
Wilbert S Aronow, Tatyana A Shamliyan
BACKGROUND: A critical appraisal of all pooled evidence regarding novel oral anticoagulants (NOACs) for stroke prevention regardless of publication status or study design has not been conducted yet. Being the latest addition to NOACs, the data on edoxaban are especially scarce. STUDY QUESTION: What are the comparative clinical outcomes of edoxaban versus warfarin and other NOACs apixaban, dabigatran, or rivaroxaban in adults with nonvalvular atrial fibrillation? DATA SOURCES: Randomized controlled trials (RCTs), observational studies, and network meta-analyses were identified in PubMed, EMBASE, the Cochrane Library, Pharmapendium, Elsevier Clinical Pharmacology, and the clinicaltrials...
September 18, 2018: American Journal of Therapeutics
Remo Melchio, Gianluca Rinaldi, Elisa Testa, Alessia Giraudo, Cristina Serraino, Christian Bracco, Laura Spadafora, Andrea Falcetta, Stefano Leccardi, Alberto Silvestri, Luigi Fenoglio
The aim of the study was to evaluate the prognostic role of red cell distribution width (RDW) in a broad population of patients hospitalized for acute heart failure (AHF). In a retrospective cohort observational study, 451 consecutive patients discharged for AHF were categorized in patients with low RDW (≤ 14.8%) and high RDW (> 14.8%). The rates of death from all causes or of hospital readmission for worsening heart failure and death were determined after a median follow-up of 18 months. The overall population has a median age of 80 years (IQR 72-85), 235 patients (52%) were males...
October 1, 2018: Internal and Emergency Medicine
Maddalena Casale, Stefania Picariello, Felice Corvino, Giuseppe Cerasari, Saverio Scianguetta, Francesca Rossi, Marcello Persico, Silverio Perrotta
A 20-year-old male affected by transfusion-dependent β-thalassemia (β-thal), was prescribed intensive chelation therapy with deferoxamine (DFO) and deferiprone (DFP) because of severe hepatic and cardiac iron overload and β-blocker and warfarin to manage a previous event of atrial fibrillation (AFib) and heart failure. After a few months, he developed critical liver failure, renal tubulopathy and severe electrolyte imbalance. Laboratory and instrumental evaluations were performed to carry out differential diagnosis of acute liver failure and an exclusion diagnosis of drug induced liver injury (DILI) was made...
September 25, 2018: Hemoglobin
Liliana Reis, Luís Paiva, Marco Costa, Joana Silva, Rogério Teixeira, Ana Botelho, Paulo Dinis, Marta Madeira, Joana Ribeiro, José Nascimento, Lino Gonçalves
INTRODUCTION: Percutaneous closure of the left atrial appendage (LAA) is a promising therapy in patients with atrial fibrillation with high risk for stroke and contraindication for oral anticoagulation (OAC). Intracardiac echocardiography (ICE) may make this percutaneous procedure feasible in patients in whom transesophageal echocardiography (TEE) is inadvisable. Our aim was to assess the efficacy and safety of LAA closure and the feasibility of ICE compared to TEE to guide the procedure...
September 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Luke C Pilling, Janice L Atkins, George A Kuchel, Luigi Ferrucci, David Melzer
Higher Red Blood Cell Distribution Width (RDW or anisocytosis) predicts incident coronary artery disease (CAD) plus all-cause and cardiovascular mortality, but its predictive value for other common diseases in healthy volunteers is less clear. We aimed to determine the shorter and longer term associations between RDW and incident common conditions in participants free of baseline disease, followed for 9 years. We undertook a prospective analysis of RDW% using 240,477 healthy UK Biobank study volunteers aged 40-70 years at baseline, with outcomes ascertained during follow-up (≤9 years)...
2018: PloS One
Roman Nevzorov, Ilan Goldenberg, Yuval Konstantino, Gregory Golovchiner, Boris Strasberg, Mahmoud Souleiman, Vladimir Khalameizer, Shlomit Ben-Zvi, Ron Sela, Shimon Rosenheck, Nahum A Freedberg, Michael Geist, Michal Einhorn Cohen, Tal Cohen, Nir Shlomo, Natalie Gabrielov-Yusim, Diklah Geva, Michael Glikson, Moti Haim
INTRODUCTION: Life expectancy of less than 1 year is usually a contraindication for implantable cardioverter defibrillator (ICD) implantation. The aim was to identify patients at risk of death during the first year after implantation. METHODS AND RESULTS: Data were derived from a prospective Israeli ICD Registry. Two groups of patients were compared, those who died and those who were alive 1 year after ICD implantation. Factors associated with 1-year mortality were identified on a derivation cohort...
August 31, 2018: Journal of Cardiovascular Electrophysiology
Heidi Lehtola, Antti Palomäki, Pirjo Mustonen, Päivi Hartikainen, Tuomas Kiviniemi, Henri Sallinen, Ilpo Nuotio, Antti Ylitalo, K E Juhani Airaksinen, Juha Hartikainen
Background: Intracranial hemorrhage is the most devastating complication in patients with atrial fibrillation (AF) receiving oral anticoagulation (OAC). It can be either spontaneous or caused by head trauma. We sought to address the prevalence, clinical characteristics, and prognosis of traumatic and spontaneous intracranial hemorrhages in AF patients on OAC. Methods: Multicenter FibStroke registry of 5,629 patients identified 592 intracranial hemorrhages during warfarin treatment between 2003 and 2012...
August 2018: Neurology. Clinical Practice
Takahide Arai, Fumiaki Yashima, Ryo Yanagisawa, Makoto Tanaka, Hideyuki Shimizu, Keiichi Fukuda, Yusuke Watanabe, Toru Naganuma, Motoharu Araki, Norio Tada, Futoshi Yamanaka, Shinichi Shirai, Masanori Yamamoto, Kentaro Hayashida
BACKGROUND: There is limited data on hospital readmissions following transcatheter aortic valve implantation (TAVI). The aim of this study was to investigate hospital readmissions post-TAVI. METHODS: Data from the Optimized transCathEter vAlvular iNtervention (OCEAN-TAVI) multicenter registry (registration no. UMIN000020423) were collected from 1215 patients who underwent TAVI. Incidence, timing, causes, and predictors of readmission in addition to the impact on patient outcomes were analyzed...
October 15, 2018: International Journal of Cardiology
Sarah Eisho, Nouran M Salem, Janet L Hoffman, John M Koerber, Maureen A Smythe
OBJECTIVES: To identify patient characteristics, bleed management, and bleed outcomes in patients experiencing an apixaban major bleeding event and to identify opportunities to improve the safe use of apixaban. METHODS: This retrospective single health-system study identified apixaban patients experiencing a major bleeding event between January 2013 and May 2016 through electronic medical record review. Patient characteristics, bleed management, and outcomes were extracted in those with a confirmed major bleed assessed by the International Society on Thrombosis and Haemostasis criteria...
October 2018: Hospital Practice (Minneapolis)
Gianluigi Savarese, Domenico D'Amario
Heart failure (HF) represents a global pandemic health problem with a high impact on health-care costs, affecting about 26 million adults worldwide. The overall HF prevalence and incidence are ~2% and ~0.2% per year, respectively, in Western countries, with half of the HF population with reduced ejection fraction (HFpEF) and half with preserved (HFpEF) or mid-range ejection fraction (HFmrEF). Sex differences may exist in HF. More males have HFrEF or HFmrEF and an ischemic etiology, whereas more females have HFpEF and hypertension, diastolic dysfunction, and valvular pathologies as HF etiologies...
2018: Advances in Experimental Medicine and Biology
Hira Shaikh, Ahmed Khattab, Muhammad S Faisal, Abhishek Chilkulwar, Mary Albrethsen, Santhosh Sadashiv, Salman Fazal
Background Ibrutinib, a Bruton's tyrosine kinase inhibitor has reformed the treatment of various B-cell malignancies including chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's macroglobulinemia. Although generally well tolerated, here we describe our institutional experience of unique adverse effects encountered with the use of ibrutinib in patients with B-cell lymphomas. Methods This is a retrospective observational study done at a tertiary care facility, to evaluate adverse events in patients with B-cell malignancies on treatment with ibrutinib between 2014 and 2018...
July 25, 2018: Journal of Oncology Pharmacy Practice
Wei-Syun Hu, Fung-Chang Sung, Cheng-Li Lin
No abstract text is available yet for this article.
August 24, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Yusuf Ziya Şener, Metin Okşul, Cem Çöteli
No abstract text is available yet for this article.
August 24, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Yoshimori An, Hisashi Ogawa, Yugo Yamashita, Mitsuru Ishii, Moritake Iguchi, Nobutoyo Masunaga, Masahiro Esato, Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe, Gregory Y H Lip, Masaharu Akao
Aims: To investigate the causes of death and the associated clinical factors in patients with atrial fibrillation (AF) in the contemporary clinical practice. Methods and Results: The Fushimi AF Registry is a community-based prospective survey of AF patients since March 2011 in Fushimi-ku, Kyoto. We investigated causes of death and the clinical indicators of cardiovascular (CV) and non-CV death in 4,045 patients with available follow-up data by the end of November 2016...
July 18, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
Manfred Berger, Meryem Emir, Tanja Brünnler, Felix Rockmann, Ralf Lehmann
BACKGROUND: Aim of this study was to evaluate the predictors of hs-cTnT in a non-ACS patient cohort admitted to the emergency department. HYPOTHESIS: Atrial fibrillation and hypertension may not always be sufficient for elevation for hs-cTnT. METHODS: We performed a retrospective, single center study encompassing in total 1003 patients. Individuals were retrospectively divided in ACS- and non-ACS patients by two independent investigators reviewing the medical records...
August 2018: Clinical Cardiology
Hiroyuki Naito, Tomohisa Nezu, Naohisa Hosomi, Shiro Aoki, Naoto Kinoshita, Junichiro Kuga, Ryo Shimomura, Mutsuko Araki, Hiroki Ueno, Kazuhide Ochi, Hirofumi Maruyama
BACKGROUND: Malnutrition is an independent risk factor for poor outcomes in patients with acute ischemic stroke. However, the indicator of malnutrition has not yet been established. We investigated the relationship between the Controlling Nutritional Status score, a useful prognostic measure of malnutrition in patients with cardiovascular diseases and malignant tumors, and functional outcomes in patients with acute ischemic stroke. METHODS: Patients with acute ischemic stroke (n = 264, 71 ± 12 y old) were consecutively evaluated within 7 d of stroke onset...
November 2018: Nutrition
Andrew B Hughey, Xiaokui Gu, Brian Haymart, Eva Kline-Rogers, Steve Almany, Jay Kozlowski, Dennis Besley, Gregory D Krol, Syed Ahsan, Scott Kaatz, James B Froehlich, Geoffrey D Barnes
Randomized controlled trials (RCTs) examining warfarin use for stroke prevention in atrial fibrillation (AF) may not accurately reflect real-world populations. We aimed to determine the representativeness of the RCT populations to real-world patients and to describe differences in the characteristics of trial populations from trial eligible patients in a real-world setting. We hypothesized that a significant fraction of real-world patients would not qualify for the RE-LY, ROCKET-AF, and ARISTOTLE trials and that real-world patients qualifying for the studies may have more strokes and bleeding events...
October 2018: Journal of Thrombosis and Thrombolysis
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