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Chip DBM

Van-Viet Nguyen, Hyohyun Nam, Young Joe Choe, Bok-Hyung Lee, Jung-Dong Park
We present an X-band bi-directional transmit/receive module (TRM) for a phased array system utilized in radar-based sensor systems. The proposed module, comprising a 6-bit phase shifter, a 6-bit digital step attenuator, and bi-directional gain amplifiers, is fabricated using 65-nm CMOS technology. By constructing passive networks in the phase-shifter and the variable attenuator, the implemented TRM provides amplitude and phase control with 360° phase coverage and 5.625° as the minimum step size while the attenuation range varies from 0 to 31...
August 6, 2018: Sensors
Adam Khalifa, Yasha Karimi, Qihong Wang, Sahithi Garikapati, Webert Montlouis, Milutin Stanacevic, Nitish Thakor, Ralph Etienne-Cummings
An implant that can electrically stimulate neurons across different depths and regions of the brain currently does not exist as it poses a number of obstacles that need to be solved. In order to address the challenges, this paper presents the concept of "microbead," a fully integrated wirelessly powered neural device that allows for spatially selective activation of neural tissue. The prototype chip is fabricated in 130-nm CMOS technology and currently measures 200 μm × 200 μm, which represents the smallest remotely powered stimulator to date...
June 2018: IEEE Transactions on Biomedical Circuits and Systems
Sae-Kyoung Kang, Joon Young Huh, Jie Hyun Lee, Joon Ki Lee
We design and implement a cost-effective and compact 100-Gb/s (2 × 50 Gb/s) PAM-4 receiver optical sub-assembly (ROSA) by using a TO-can package instead of an expensive box-type package. It consists of an optical demultiplexer, two PIN-PDs and a 2-channel linear transimpedance amplifier. The components are passively aligned and assembled using alignment marks engraved on each part. With a real-time PAM-4 DSP chip, we measured the back-to-back receiver sensitivities of the 100-Gb/s ROSA based on TO-56 to be less than -13...
March 5, 2018: Optics Express
Kok-Hin Teng, Tong Wu, Xiayun Liu, Zhi Yang, Chun-Huat Heng
An 8-channel wireless neural signal processing IC, which can perform real-time spike detection, alignment, and feature extraction, and wireless data transmission is proposed. A reconfigurable BFSK/QPSK transmitter (TX) at MICS/MedRadio band is incorporated to support different data rate requirement. By using an Exponential Component-Polynomial Component (EC-PC) spike processing unit with an incremental principal component analysis (IPCA) engine, the detection of neural spikes with poor SNR is possible while achieving 625× data reduction...
June 2017: IEEE Transactions on Biomedical Circuits and Systems
Paolo Giannoni, Federico Villa, Cinzia Cordazzo, Luciano Zardi, Paolo Fattori, Rodolfo Quarto, Mauro Fiorini
Three different heterologous substitutes for bone regeneration, manufactured with equine-derived cortical powder (CP), cancellous chips (CC) and demineralized bone matrix granules (DBM), were compared in in vitro and in vivo settings. We tested: a commercially available bone paste (Osteoplant-Activagen™, consisting of aqueous collagenous carrier, CP, DBM; named A); a second-generation injectable paste (20 kDa polyethylene glycol/hydroxypropyl-methyl cellulose-based hydrogel, CP, DBM; B); a pre-formed bone filler (400 kDa polyethylene oxide/hydroxypropyl-methyl cellulose-based hydrogel, CP, CC, DBM; C)...
November 18, 2016: Biomaterials Science
Jin-Chern Chiou, Shun-Hsi Hsu, Yu-Te Liao, Yu-Chieh Huang, Guan-Ting Yeh, Cheng-Kai Kuei, Kai-Shiun Dai
This paper presents a wireless on-lens intraocular pressure monitoring system, comprising a capacitance-to-digital converter and a wirelessly powered radio-frequency identification (RFID)-compatible communication system, for sensor control and data communication. The capacitive sensor was embedded on a soft contact lens of 200 μm thickness using commercially available biocompatible lens material, to improve compliance and reduce user discomfort. The sensor chip was shown to achieve effective number of bits greater than 10 over a capacitance range up to 50 pF while consuming only 64-μW power...
September 2016: IEEE Journal of Biomedical and Health Informatics
Reza Motaghiannezam, Ilya Lyubomirsky, Henry Daghighian, Chris Kocot, Timo Gray, Jim Tatum, Adrian Amezcua-Correa, M Bigot-Astruc, D Molin, F Achten, P Sillard
We demonstrate successful transmission of four 45 Gbps PAM4 single-channels through OM4 multimode fibers (MMFs) and wideband MMF using a PAM4 PHY chip and four vertical cavity surface emitting lasers (VCSELs) with wavelengths ranging over short wavelength division multiplexing (SWDM) grid. Real-time bit error ratios (BERs) < 2 × 10<sup>-4</sup> were achieved for all four 45 Gbps PAM4 SWDM grid channels over 100 m, 200 m, and 300 m of wideband OM4 MMFs. All four channel received PAM4 optical eyes are shown after propagating through 100 m, 200 m, and 300 m of wideband OM4 as well as 100 m and 200 m conventional OM4 MMFs...
July 25, 2016: Optics Express
Carlos Sánchez-Azqueta, Bernhard Goll, Santiago Celma, Horst Zimmermann
A monolithically integrated optoelectronic receiver with a low-capacitance on-chip pin photodiode is presented. The receiver is fabricated in a 0.35 μm opto-CMOS process fed at 3.3 V and due to the highly effective integrated pin photodiode it operates at μW. A regenerative latch acting as a sense amplifier leads in addition to a low electrical power consumption. At 400 Mbit/s, sensitivities of -26.0 dBm and -25.5 dBm are achieved, respectively, for λ = 635 nm and λ = 675 nm (BER = 10(-9) ) with an energy efficiency of 2 pJ/bit...
May 25, 2016: Sensors
Reza Motaghiannezam, Thang Pham, Alan Chen, Tengda Du, Chris Kocot, Jack Xu, Bernd Huebner
Real-time 52 Gbps PAM4 transmission is demonstrated over single mode fiber (SMF) using a directly modulated laser (DML) and a PHY chip. The inner eye optical modulation amplitude (OMA) receiver sensitivities were measured and compared using avalanche photodetector (APD) and PIN photodetector (PD) for the maximum and minimum chromatic dispersions (CDs) of 400GBase-LR8 link. The measured inner eye OMAs were -17.8 dBm and -18.8 dBm for + 10 ps/nm and -58 ps/nm of CDs at the KP4 bit error rate (BER) threshold of 2 × 10<sup>-4</sup> using a PIN PD, respectively...
April 4, 2016: Optics Express
Andre L Mansano, Yongjia Li, Sumit Bagga, Wouter A Serdijn
The design of a 13.56 MHz/402 MHz autonomous wireless sensor node with asynchronous ECG monitoring for near field communication is presented. The sensor node consists of an RF energy harvester (RFEH), a power management unit, an ECG readout, a data encoder and an RF backscattering transmitter. The energy harvester supplies the system with 1.25 V and offers a power conversion efficiency of 19% from a -13 dBm RF source at 13.56 MHz. The power management unit regulates the output voltage of the RFEH to supply the ECG readout with VECG = 0...
June 2016: IEEE Transactions on Biomedical Circuits and Systems
Mohammed Shafiqul Hai, Michaël Ménard, Odile Liboiron-Ladouceur
A novel photoreceiver architecture enabling parallel processing in the electronic domain of a high-speed optical signal is demonstrated. This allows the electronics to operate at significantly lower frequency than the optical signal and hence reduce power consumption and the impact of parasitics. The photoreceiver performs optical time sampling with four integrated SiGe photodetectors connected in series by waveguide delay lines. Four variations of the optical time sampling receiver are designed and demonstrated which differ by the data rate (10 Gb/s and 20 Gb/s) and silicon delay waveguide loss (2...
December 14, 2015: Optics Express
Zhengliang Wang, Hui Yang, Pei He, Yonghui He, Jishou Zhao, Huaijun Tang
A series of ternary dinuclear europium(iii) complexes [Eu2(2,7-BTFDBC)3-n(DBM)2n(Phen)2] (n = 0, 1, or 2) were synthesized by using 2,7-bis(4'4'4'-trifluoro-1,3-dioxobutyl)-(9-ethyl-9H-carbazole) (2,7-BTFDBC), dibenzoylmethane (DBM), 1,10-phenanthroline (Phen) and europium(iii) ions. All these complexes display a broad excitation band in the blue region and high intensity emission with high colour purity. The intensity of emission significantly increases with the increase of DBM in [Eu2(2,7-BTFDBC)3-n(DBM)2n(Phen)2] (n = 0, 1, or 2)...
February 21, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Chin-Lung Yang, Gou-Tsun Zheng
This study proposes using wireless low power thermal sensors for basal-body-temperature detection using frequency modulated telemetry devices. A long-term monitoring sensor requires low-power circuits including a sampling circuit and oscillator. Moreover, temperature compensated technologies are necessary because the modulated frequency might have additional frequency deviations caused by the varying temperature. The temperature compensated oscillator is composed of a ring oscillator and a controlled-steering current source with temperature compensation, so the output frequency of the oscillator does not drift with temperature variations...
November 20, 2015: Sensors
Hongming Lyu, Huaqiang Wu, Jinbiao Liu, Qi Lu, Jinyu Zhang, Xiaoming Wu, Junfeng Li, Teng Ma, Jiebin Niu, Wencai Ren, Huiming Cheng, Zhiping Yu, He Qian
A monolithic double-balanced graphene mixer integrated circuit (IC) has been successfully designed and fabricated. The IC adopted the cross-coupled resistive mixer topology, integrating four 500 nm-gate-length graphene field-effect transistors (GFETs), four on-chip inductors, and four on-chip capacitors. Passive-first-active-last fabrication flow was developed on 200 mm CMOS wafers. CMOS back-end-of-line processes were utilized to realize most fabrication steps followed by GFET-customized processes. Test results show excellent output spectrum purity with suppressed radio frequency (RF) and local oscillation (LO) signals feedthroughs, and third-order input intercept (IIP3) reaches as high as 21 dBm...
October 14, 2015: Nano Letters
Matthew B Murphy, Richard K Suzuki, Theodore T Sand, Christopher D Chaput, Carl A Gregory
For spinal fusions and the treatment of non-union fractures, biological substrates, scaffolds, or carriers often are applied as a graft to support regeneration of bone. The selection of an appropriate material critically influences cellular function and, ultimately, patient outcomes. Human bone marrow mesenchymal stem cells (BMSCs) are regarded as a critical component of bone healing. However, the interactions of BMSCs and commercial bone matrices are poorly reported. BMSCs were cultured with several commercially available bone substrates (allograft, demineralized bone matrix (DBM), collagen, and various forms of calcium phosphates) for 48 h to understand their response to graft materials during surgical preparation and the first days following implantation (cell retention, gene expression, pH)...
2013: Journal of Clinical Medicine
Pedro J Reyes Martínez, Pablo A Marrero Barrera
Humeral shaft non-unions occur in 2-10% of all fracture cases. Increased incidence of these non-unions can be associated with ORIF, comminution, high impact injuries, bone loss or fracture gaping. Treatment guidelines for fracture non-union state that fractures with gaps greater than 4 cm should be treated with vascularized fibular autografts or transportation with an external fixator. Unfortunately these modalities carry considerable donor site morbidity and patient will experience considerable discomfort, especially when dealing with an external fixator...
2014: Boletín de la Asociación Médica de Puerto Rico
Aqueel H Pabaney, Kevin A Reinard, Karam Asmaro, Ghaus M Malik
OBJECTIVE: A versatile neurosurgical approach, the retrosigmoid craniectomy (RS) has traditionally been associated with high rates of post-operative cerebrospinal fluid (CSF) leak, headaches, and aesthetic defects. We introduce a simple surgical strategy for bony cranial reconstruction designed to minimize peri-operative complications and improve cosmetic outcomes. METHODS: In accordance with the Institutional Review Board, the senior author's (G.M.M.) records were queried between 2006 and 2014...
September 2015: Clinical Neurology and Neurosurgery
Zhibin Xiao, Xi Tan, Xianliang Chen, Sizheng Chen, Zijian Zhang, Hualei Zhang, Junyu Wang, Yue Huang, Peng Zhang, Lirong Zheng, Hao Min
This paper presents a wirelessly powered implantable electrochemical sensor tag for continuous blood glucose monitoring. The system is remotely powered by a 13.56-MHz inductive link and utilizes an ISO 15693 radio frequency identification (RFID) standard for communication. This paper provides reliable and accurate measurement for changing glucose level. The sensor tag employs a long-term glucose sensor, a winding ferrite antenna, an RFID front-end, a potentiostat, a 10-bit sigma-delta analog to digital converter, an on-chip temperature sensor, and a digital baseband for protocol processing and control...
May 2015: IEEE Journal of Biomedical and Health Informatics
Fangming Deng, Yigang He, Bing Li, Lei Zuo, Xiang Wu, Zhihui Fu
This paper presents a novel monolithic pressure sensor tag for passive wireless applications. The proposed pressure sensor tag is based on an ultra-high frequency RFID system. The pressure sensor element is implemented in the 0.18 µm CMOS process and the membrane gap is formed by sacrificial layer release, resulting in a sensitivity of 1.2 fF/kPa within the range from 0 to 600 kPa. A three-stage rectifier adopts a chain of auxiliary floating rectifier cells to boost the gate voltage of the switching transistors, resulting in a power conversion efficiency of 53% at the low input power of -20 dBm...
2015: Sensors
Guenther Schuldt Filho, Jordi Caballé-Serrano, Kosaku Sawada, Dieter D Bosshardt, Marco Aurélio Bianchini, Daniel Buser, Reinhard Gruber
BACKGROUND: Demineralized bone matrix (DBM) is used for the treatment of osseous defects. Conditioned medium from native bone chips can activate transforming growth factor (TGF)-β signaling in mesenchymal cells. The aim of this study is to determine whether processing of native bone into DBM affects the activity of the conditioned medium. METHODS: Porcine cortical bone blocks were subjected to defatting, different concentrations of hydrochloric acid, and various temperatures...
June 2015: Journal of Periodontology
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