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fetal AND growth

Nathalie J M Bravo-Valenzuela, Paulo Zielinsky, Jesús Zurita-Peralta, Luiz Henrique Nicoloso, Antonio Piccoli, Luiza Ferreira Van der Sand, Natássia Miranda Sulis, Camila Carvalho Ritter
INTRODUCTION: In intrauterine growth restriction (IUGR), increased uteroplacental vascular impedance contributes to preferential flow to left ventricle (LV), with consequent alteration of its compliance and increased left atrial (LA) pressure. Pulmonary vein pulsatility index (PVPI) reflects the increased impedance to LA filling and could be used as a cardiac monitoring parameter in IUGR. MATERIAL AND METHODS: A total of 27 IUGR fetuses (group 1), 28 fetuses with appropriate growth for gestational age from hypertensive mothers (group 2), and 28 controls (group 3) were studied...
August 17, 2018: Fetal Diagnosis and Therapy
Dibyendu Biswas, Kyoung Ha So, Seon Ung Hwang, Junchul David Yoon, Mirae Kim, Dae Young Kim, Sang Hwan Hyun
Current research suggests that supplementing in vitro culture (IVC) media with vascular endothelial growth factor (VEGF) may have beneficial effects on the development of porcine embryos in vitro. However, the molecular signaling mechanisms underlying this effect are unclear. Therefore, we aimed to investigate the effects of VEGF on molecular signaling events during in vitro embryonic development of porcine embryos. Porcine oocytes matured in vitro were fertilized, and the resultant zygotes were cultured with 5 ng/mL of VEGF supplemented with or without fetal bovine serum from day 4 till day 7...
August 16, 2018: Theriogenology
Mara Cavallin, Amandine Bery, Camille Maillard, Laurent J Salomon, Christine Bole, Madeline Louise Reilly, Patrick Nitschké, Nathalie Boddaert, Nadia Bahi-Buisson
Autosomal recessive missense Rotatin (RTTN) mutations are responsible for syndromic forms of malformation of cortical development, ranging from isolated polymicrogyria to microcephaly associated with primordial dwarfism and other major malformations. We identified, by trio based whole exome sequencing, a homozygous missense mutation in the RTTN gene (c.2953A > G; p.(Arg985Gly)) in one Moroccan patient from a consanguineous family. The patient showed early onset primary microcephaly, detected in the fetal period, postnatal growth restriction, encephalopathy with hyperkinetic movement disorders and self-injurious behavior with sleep disturbance...
August 16, 2018: European Journal of Medical Genetics
Francesca Gaccioli, Ulla Sovio, Emma Cook, Martin Hund, D Stephen Charnock-Jones, Gordon C S Smith
BACKGROUND: Fetal growth restriction is a major determinant of perinatal morbidity and mortality. This condition has no gold standard definition, but a widely used proxy is delivery of a small for gestational age infant (<10th percentile) combined with an adverse pregnancy outcome. Effective screening for fetal growth restriction is an area of unmet clinical need. We aimed to determine the diagnostic effectiveness of a combination of ultrasonic fetal biometry and measurement of the ratio of soluble fms-like tyrosine kinase receptor 1 (sFLT1) to placental growth factor (PlGF) in predicting adverse pregnancy outcomes associated with delivery of a small for gestational age infant...
August 2018: Lancet Child & Adolescent Health
S L Semple, N T K Vo, S J Poynter, M Li, D D Heath, S J DeWitte-Orr, B Dixon
Despite increased global interest in Chinook salmon aquaculture, little is known of their viral immune defenses. This study describes the establishment and characterization of a continuous cell line derived from Chinook salmon spleen, CHSS, and its use in innate immune studies. Optimal growth was seen at 14-18 °C when grown in Leibovitz's L-15 media with 20% fetal bovine serum. DNA analyses confirmed that CHSS was Chinook salmon and genetically different from the only other available Chinook salmon cell line, CHSE-214...
August 14, 2018: Developmental and Comparative Immunology
Isabelle Monier, Anne Ego, Alexandra Benachi, Pierre-Yves Ancel, François Goffinet, Jennifer Zeitlin
BACKGROUND: Accurate estimation of fetal weight is needed for growth monitoring and decision-making in obstetrics; the INTERGROWTH-21st Project developed an estimated fetal weight formula in order to construct new intrauterine growth standards. OBJECTIVE: To compare the accuracy of the Hadlock and INTERGROWTH formulas for the estimation of fetal weight among preterm infants. STUDY DESIGN: Using the EPIPAGE 2 population-based study of births between 22 and 34 weeks of gestation, we included 578 non-anomalous singleton fetuses with an ultrasound-to-delivery interval <2 days...
August 14, 2018: American Journal of Obstetrics and Gynecology
Nathan R Blue, Meghan E Beddow, Mariam Savabi, Vivek R Katukuri, Conrad R Chao
BACKGROUND: The fetal growth standard in widest use was published by Hadlock more than 25 years ago and was derived from a small, homogeneous cohort. In 2015, The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Study published updated standards that are specific to race/ethnicity. These do not allow for precise estimated fetal weight (EFW) percentile calculation, however, and their effectiveness to predict neonatal morbidity and small for gestational age (SGA) has not yet been compared to the longstanding Hadlock standard...
August 14, 2018: American Journal of Obstetrics and Gynecology
Vanessa R Kay, Matthew T Ratsep, Lindsay S Cahill, Andrew F Hickman, Bruno Zavan, Margaret E Newport, Jacob Ellegood, Christine L Laliberte, James N Reynolds, Peter Carmeliet, Chandrakant Tayade, John G Sled, B Anne Croy
Preeclampsia, a hypertensive syndrome occurring in 3-5% of human pregnancies, has lifelong health consequences for the fetus. Cognitive ability throughout life is altered and adult stroke risk is increased in these offspring. One potential etiological factor for altered brain development is low concentrations of pro-angiogenic placental growth factor (PGF). Impaired PGF production may promote an anti-angiogenic fetal environment during neural and cerebrovascular development. We previously reported delayed vascularization of the hindbrain, altered retinal vascular organization and less connectivity in the circle of Willis in Pgf-/- mice...
August 17, 2018: Physiological Genomics
Chengfang Xu, Zhenyan Han, Ping Li, Xuejiao Li
Gestational diabetes mellitus (GDM) is a metabolic disease with symptoms of hyperglycemia, insulin resistance and fetal maldevelopment. Evidence has indicated that fibroblast growth factor (FGF)-21 is a multifunctional protein and exhibits potential therapeutic value for metabolic diseases. The present study investigated the diagnostic value of FGF-21 serum levels in patients with GDM (n=50) and age-matched healthy individuals (n=50). It was demonstrated that the gene and protein expression levels of FGF-21 were downregulated in adipose cells in patients with GDM compared with those in healthy individuals...
August 2018: Experimental and Therapeutic Medicine
Stefanie N Hinkle, Michael Y Tsai, Shristi Rawal, Paul S Albert, Cuilin Zhang
We aimed to examine the prospective association between first trimester HbA1c and gestational diabetes (GDM) and explore the utility of HbA1c for prediction of GDM. We used data from a case-control study within the prospective NICHD Fetal Growth Studies-Singleton Cohort (2009-2013), which enrolled 2,802 women at 12 U.S. clinical centers. HbA1c was measured in GDM cases (n = 107) and matched controls (n = 214) targeted at 8-13, 16-22, 24-29, and 34-37 gestational weeks. We excluded women with HbA1c  ≥ 6...
August 16, 2018: Scientific Reports
Ji-Yeon Lee, Jie Min Kim, Da Som Jeong, Myoung Hee Kim
HOX genes are transcription factors that play important roles in body patterning and many cellular processes during embryonic, fetal, and adult development. Given their important function in normal tissues, it is reasonable to assume that abnormal expression of HOX genes in adults could lead to serious diseases such as cancer. Our previous study reported HOXB5 to be significantly up-regulated in breast cancer, and its expression was found to be associated with tumor cell proliferation and invasion. Furthermore, the epidermal growth factor receptor (EGFR), a cellular tyrosine kinase that plays an important role in breast cancer progression, was found significantly up-regulated by HOXB5 in ER-positive breast cancer cells...
August 13, 2018: Biochemical and Biophysical Research Communications
Jin Zhou, Chunyan Zhu, Hanwen Luo, Lang Shen, Jun Gong, Yimeng Wu, Jacques Magdalou, Liaobin Chen, Yu Guo, Hui Wang
Epidemiologic studies showed that low birth weight is associated with high cholesterol and an increased risk of cardiovascular diseases in adulthood. This study aimed to elucidate the intrauterine programming mechanisms of adult hypercholesterolemia. The results showed that prenatal nicotine exposure (PNE) caused intrauterine growth retardation and hypercholesterolemia in male adult offspring rats. Hepatic cholesterol synthesis and output were deceased in utero but increased in adults; hepatic reverse cholesterol transport (RCT) persistently deceased before and after birth...
August 16, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Malihe Botyar, Rozita Khoramroudi
Seasons and Vitamin D are factors that are directly and indirectly related to ultraviolet (UV) radiations and can affect pregnancy. Therefore, the present study aims at investigating the effects of being exposed to direct UV radiation during pregnancy period and its effects on fetal growth, premature birth, and high blood pressure. This study was conducted by searching different websites such as Medline, Embase, ProQuest, Global Health, Google Scholar, and Scopus. Of the 430 papers found, between 1985 and 2017, seventeen related articles were used...
May 2018: Journal of Family Medicine and Primary Care
Ali Alhousseini, Sunil Jaiman, Edgar Hernandez-Andrade, Salam Zeineddine, Faisal Qureshi, Suzanne M Jacques
Background: Thrombosis of one of the umbilical arteries can be associated with adverse pregnancy outcomes such as stillbirth and severe intrauterine growth restriction (IUGR). Case: A 21-year-old gravida 1 patient, with a history of 3-vessel cord at 20 weeks, presented at 29 weeks with a single umbilical artery. The estimated fetal weight measurements at 26 weeks, 29 weeks, and 31 weeks were at the 27th percentile, the 26th percentile, and less than the 5th percentile, respectively...
2018: Case Reports in Obstetrics and Gynecology
Wen Shu, Hanying Li, Hao Gong, Mei Zhang, Xiulong Niu, Yongqiang Ma, Xin Zhang, Wei Cai, Guohong Yang, Maoti Wei, Ning Yang, Yuming Li
Preeclampsia is a pregnancy-specific disease characterized by hypertension as well as proteinuria after the 20th week of pregnancy. Animal models are effective tools for studying the pathogenesis, diagnostic criteria and treatment methods of preeclampsia. The present study sought to establish and evaluate a preeclampsia-like Sprague Dawley (SD) rat model using N-nitro-L-arginine methyl ester (L-NAME). Rats were randomly assigned to 7 groups (n=10 in each): Control rats and rats treated with low-dose L-NAME (40 mg/kg body weight/day) starting from gestational day (GD) 9, medium-L-NAME (75 mg/kg body weight/day) starting from GD 9 (9D ML group), high-dose L-NAME (125 mg/kg body weight/day) starting from GD 9, low-dose L-NAME starting from GD 10, medium-dose L-NAME starting from GD 10 and high-dose L-NAME starting from GD 10...
August 2018: Experimental and Therapeutic Medicine
Stefan Kuhle, Bryan Maguire, Hongqun Zhang, David Hamilton, Alexander C Allen, K S Joseph, Victoria M Allen
BACKGROUND: While there is increasing interest in identifying pregnancies at risk for adverse outcome, existing prediction models have not adequately assessed population-based risks, and have been based on conventional regression methods. The objective of the current study was to identify predictors of fetal growth abnormalities using logistic regression and machine learning methods, and compare diagnostic properties in a population-based sample of infants. METHODS: Data for 30,705 singleton infants born between 2009 and 2014 to mothers resident in Nova Scotia, Canada was obtained from the Nova Scotia Atlee Perinatal Database...
August 15, 2018: BMC Pregnancy and Childbirth
Ramkumar Mohan, Daniel C Baumann, Emilyn U Alejandro
The prevalence of obesity and type 2 (T2D) diabetes is a major health concern in the United States and around the world. T2D is a complex disease characterized by pancreatic β-cell failure in association with obesity and insulin resistance in peripheral tissues. Although several genes associated with T2D have been identified, it is speculated that genetic variants account for only less than 10% of the risk for this disease. A strong body of data from both human epidemiological and animal studies shows that fetal nutrient factors in utero confer significant susceptibility to T2D...
August 15, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Nilgun Yildirim, Aykut Bahceci
Trastuzumab and pertuzumab are monoclonal antibodies used for the treatment of breast cancer. Until now, there have been no reports on the use of pertuzumab during pregnancy and on its potential effects on the fetus. Herein, we present a breast cancer patient who received trastuzumab and pertuzumab treatment during the first 20 weeks of pregnancy. This 22-year-old patient initially diagnosed with invasive ductal carcinoma of the breast was found to be negative for estrogen receptor and progesterone receptor and positive for human epidermal growth factor receptor in the immunohistochemical examination...
September 2018: Anti-cancer Drugs
Sofia Nahavandi, Jas-Mine Seah, Alexis Shub, Christine Houlihan, Elif I Ekinci
Large birthweight, or macrosomia, is one of the commonest complications for pregnancies affected by diabetes. As macrosomia is associated with an increased risk of a number of adverse outcomes for both the mother and offspring, accurate antenatal prediction of fetal macrosomia could be beneficial in guiding appropriate models of care and interventions that may avoid or reduce these associated risks. However, current prediction strategies which include physical examination and ultrasound assessment, are imprecise...
2018: Frontiers in Endocrinology
Birju A Shah, James F Padbury, Michael P Anderson, Michael F Holick, Edgardo Szyld, Catherine M Gordon
OBJECTIVE: To evaluate vitamin D inadequacy among extremely low-birth-weight (ELBW, <1000 g) infants and the association between circulating vitamin D concentrations and perinatal-neonatal outcomes. STUDY DESIGN: Prospective cohort study of ELBW infants in the neonatal ICU. Blood was collected within the first 3 days after birth after obtaining informed consent. Circulating 25-hydroxyvitamin D concentrations (25(OH)D) were quantified using liquid chromatography-tandem mass spectroscopy and classified as vitamin D deficient, insufficient, or adequate ( < 20, 20-30, or > 30 ng/mL, respectively)...
August 14, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
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