Suzanne O Nolan, Patrick R Melugin, Kirsty R Erickson, Wilson R Adams, Zahra Z Farahbakhsh, Colleen E Mcgonigle, Michelle H Kwon, Vincent D Costa, Christopher C Lapish, Troy A Hackett, Verginia C Cuzon Carlson, Christos Constantinidis, Kathleen A Grant, Cody A Siciliano
Human and non-human primate data clearly implicate the dorsolateral prefrontal cortex (dlPFC) as critical for advanced cognitive functions 1,2 . It is thought that intracortical synaptic architectures within dlPFC are the integral neurobiological substrate that gives rise to these processes, including working memory, inferential reasoning, and decision-making 3-7 . In the prevailing model, each cortical column makes up one fundamental processing unit composed of dense intrinsic connectivity, conceptualized as the 'canonical' cortical microcircuit 3,8 ...
September 24, 2023: bioRxiv