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Predicting risk of chronic disease

Mona Munteanu, Raluca Pais, Valentina Peta, Olivier Deckmyn, Joseph Moussalli, Yen Ngo, Marika Rudler, Pascal Lebray, Frederic Charlotte, Vincent Thibault, Olivier Lucidarme, An Ngo, Françoise Imbert-Bismut, Chantal Housset, Dominique Thabut, Vlad Ratziu, Thierry Poynard
BACKGROUND: Although the FibroTest has been validated as a biomarker to determine the stage of fibrosis in non-alcoholic fatty liver disease (NAFLD) with results similar to those in chronic hepatitis C (CHC), B (CHB), and alcoholic liver disease (ALD), it has not yet been confirmed for the prediction of liver-related death. AIM: To validate the 10-year prognostic value of FibroTest in NAFLD for the prediction of liver-related death. METHOD: Patients in the prospective FibroFrance cohort who underwent a FibroTest between 1997 and 2012 were pre-included...
October 17, 2018: Alimentary Pharmacology & Therapeutics
Manuel Giraldo-Grueso, Dario Echeverri
Prevalence of diabetes mellitus has increased drastically over time, especially in more populous countries such as the United States, India, and China. Patients with diabetes have an increased risk of major cardiovascular events such as acute myocardial infarction, cerebrovascular disease, and peripheral vascular disease. Arterial stiffness is a process related to aging and vascular, metabolic, cellular and physiological deterioration. In recent years it has been described as an independent predictor of cardiovascular mortality and coronary artery disease...
October 17, 2018: Current Diabetes Reviews
Fernando Magro, Cláudia Camila Dias, Francisco Portela, Mário Miranda, Samuel Fernandes, Sonia Bernardo, Paula Ministro, Paula Lago, Isadora Rosa, Inês Pita, Luis Correia, Pedro Pereira Rodrigues
Introduction: Ulcerative colitis (UC) is a chronic inflammatory disease often accompanied by severe and distressing symptoms that, in some patients, might require a surgical intervention (colectomy). This study aimed at determining the risk of experiencing progressive disease or requiring colectomy. Material and Methods: This was a multicenter study: patients' data (n=1481) was retrieved from the Portuguese database of inflammatory bowel disease patients. Bayesian networks and logistic regression were used to build risk matrices concerning the outcomes of interest...
October 17, 2018: Journal of Crohn's & Colitis
Chun Yuan Khoo, John Carson Allen, Shaw Yang Chia, Laura Lihua Chan, Choon Pin Lim, David Sim, Chi Keong Ching
Background: There have been conflicting data regarding the risk of sudden cardiac death (SCD) in Asian population with reduced left ventricular ejection fraction (LVEF). We aim to study mortality outcome and its risk predictors in patients with reduced LVEF who declined an implantable cardioverter defibrillator (ICD) implantation and assess whether current ICD guidelines for primary prevention are applicable to the population in Singapore. Methods: This prospective observational study involved 240 consecutive patients who fulfilled the ACC/AHA/HRS criteria for ICD implantation for primary prevention of SCD but declined ICD implantation...
October 2018: Journal of Arrhythmia
Lettie Pule, Elizabeth Buckley, Theophile Niyonsenga, David Banham, David Roder
BACKGROUND: Comorbidity is known to increase risk of death in cancer patients, both Aboriginal and non-Aboriginal. The means of measuring comorbidity to assess risk of death has not been studied in any depth in Aboriginal patients in Australia. In this study, conventional and customized comorbidity indices were used to investigate effects of comorbidity on cancer survival by Aboriginal status and to determine whether comorbidity explains survival disparities. METHODS: A retrospective cohort study was undertaken using linked population-based South Australian Cancer Registry and hospital inpatient data for 777 Aboriginal people diagnosed with primary cancer between 1990 and 2010 and 777 randomly selected non-Aboriginal controls matched by sex, birth year, diagnosis year and tumour type...
October 16, 2018: BMC Health Services Research
Adil Jadoon, Anna V Mathew, Jaeman Byun, Crystal A Gadegbeku, Debbie S Gipson, Farsad Afshinnia, Subramaniam Pennathur
BACKGROUND: The gut microbiota is altered in patients with chronic kidney disease (CKD), and cardiovascular risk increases with progressive CKD. This study examined the potential link between short chain fatty acids (SCFAs), which are produced by the gut microbiota, and cardiovascular outcomes in patients with CKD. METHODS: SCFAs were measured using a targeted liquid chromatography-mass spectrometry platform in baseline plasma samples from 214 patients with CKD enrolled in the Clinical Phenotyping Resource and Biobank Core; 81 patients with coronary artery disease (CAD) and 133 without CAD were randomly assigned to training and validation subsets...
October 16, 2018: American Journal of Nephrology
Sang-Won Lee, Do Young Kim, Sang Hoon Ahn, Yong-Beom Park, Kwang-Hyub Han, Jun Yong Park
OBJECTIVES: We evaluated the laboratory and radiological data on liver and investigate liver fibrosis induced by hepatic manifestation of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) using the aspartate aminotransferase to platelet ratio index (APRI) and an index of fibrosis (FIB-4) in 136 immunosuppressive drug-naïve patients. METHODS: We retrospectively reviewed the medical records of 136 patients with AAV without chronic liver diseases or autoimmune diseases...
October 11, 2018: Clinical and Experimental Rheumatology
Isabel V Poggiali, Ana Cristina Simões E Silva, Mariana A Vasconcelos, Cristiane S Dias, Izabella R Gomes, Rafaela A Carvalho, Maria Christina L Oliveira, Sergio V Pinheiro, Robert H Mak, Eduardo A Oliveira
BACKGROUND: Solitary functioning kidney (SFK) is an important condition in the spectrum of congenital anomalies of the kidney and urinary tract. The aim of this study was to describe the risk factors for renal injury in a cohort of patients with congenital SFK. METHODS: In this retrospective cohort study, 162 patients with SFK were systematically followed up (median, 8.5 years). The primary endpoint was time until the occurrence of a composite event of renal injury, which includes proteinuria, hypertension, and chronic kidney disease (CKD)...
October 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Dan Zhou, Fang Shi, Ying Xiong, Min Zhou, Huajing Wan, Hanmin Liu
Bronchopulmonary dysplasia (BPD) is one of the most common chronic inflammatory lung disease of premature infants, with serious short- and long-term consequences. Early identification of premature infants at risk of BPD is critical to preventing the pathogenesis of disease. Thus, in the present study, we recruited 126 premature infants, collected peripheral blood samples at different time points during early life, and measured the concentration of Th1 (MCP-1, IP-10, and MIG) and Th2 (eotaxin-1, eotaxin-2, and MCP-4) chemokines in serum...
October 15, 2018: European Journal of Pediatrics
Baiju R Shah, Sakina Walji, Alexander Kiss, Jacqueline E James, Julia M Lowe
OBJECTIVES: We sought to develop the Hypoglycemia During Hospitalization (HyDHo) scoring system, to predict the risk for hypoglycemia during hospitalization in patients with diabetes at the time of admission to a general medical unit. METHODS: We randomly selected 300 patients with diabetes who had been admitted to a medical inpatient unit at a teaching hospital. Hypoglycemia was defined as any point-of-care glucose test result ≤3.9 mmol/L. Demographic and clinical predictors of hypoglycemia were identified through review of the hospitalization record...
August 10, 2018: Canadian Journal of Diabetes
Sheng-Hsuan Chien, Yao-Chung Liu, Chia-Jen Liu, Po-Shen Ko, Hao-Yuan Wang, Liang-Tsai Hsiao, Tzeon-Jye Chiou, Jin-Hwang Liu, Jyh-Pyng Gau
BACKGROUND/PURPOSE: Patients with acute leukemia undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are exposed to high risk of developing invasive fungal infections, and the invasive mold infections (IMIs) are becoming more and more common after transplantation. Here, we conducted a retrospective study to analyze demographics, microbiology, and risk factors for IMIs development in adult acute leukemia patients undergoing allo-HSCT. METHODS: We reviewed 245 adult acute leukemia patients undergoing allo-HSCT from January 2003 to December 2014...
September 26, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Chompunoot Wangboon, Chanika Worasith, Raynoo Thanan, Chatanun Eamudomkarn, Anchalee Techasen, Jiraporn Sithithaworn, Watcharin Loilome, Nittaya Chamadol, Somchai Pinlaor, Amonrat Jumnainsong, Puangrat Yongvanit, Narong Khuntikeo, Jeffrey M Bethony, Paiboon Sithithaworn
Inflammation of the hepatobiliary system in chronic opisthorchiasis is associated with an elevated level of urinary 8-oxo-7,8 dihydro-2'deoxyguanosine (8-oxodG) during active as well as past exposure to Opisthorchis viverrini infection. In this study, we evaluated the short-term effect of praziquantel treatment on hepatobiliary disease (HBD) using urinary 8-oxodG as an inflammatory marker in a cohort of residents in endemic areas of opisthorchiasis in Khon Kaen, Thailand. The HBD status in terms of periductal fibrosis (PDF) was determined by abdominal ultrasonography and O...
October 12, 2018: Acta Tropica
Ghasem Janbabai, Abbas Alipour, Sina Ehteshami, Seyedeh-Samaneh Borhani, Touraj Farazmandfar
Trace metals are beneficial nutrient materials that act as essential cofactors in physiological processes. Recent evidence suggests that increase or decrease in certain trace metals may be related with risk and development of chronic diseases such as cancer. This study analyzed some trace elements level in hair and nail of patients with stomach cancer, and compared with their level in healthy controls. Trace elements (Cu, Fe, K, Li, Mg, Mn, Na, P, Se, Sr and Zn) are estimated in hair and nail of the 73 cancer patients and 83 controls by atomic absorption spectrophotometric method...
October 2018: Indian Journal of Clinical Biochemistry: IJCB
Xiaoyan Wang, Chongzhe Pei, Yingnan Bai, Qiying Dai, Xin Deng, Yue Liu, Zhi Li, Jieyun You, Juan Peng, Li Lin, Yunzeng Zou
We evaluated the association of preprocedure CHA2 DS2 -VASc (congestive heart failure, hypertension, age, diabetes mellitus, stroke, vascular disease, and sex) score with ischemic events in patients undergoing percutaneous coronary intervention (PCI). The Dryad Digital Repository enrolled 2533 patients between July 2009 and August 2011. We recorded 1-year ischemic events. Univariate and multivariable logistic regression analyses were used to analyze the association between CHA2 DS2 -VASc score and ischemic events...
October 15, 2018: Angiology
Daryl J McLeod, Christina B Ching, Yuri V Sebastião, Jason H Greenberg, Susan L Furth, Kirk M McHugh, Brian Becknell
BACKGROUND: Obstructive uropathy (OU) is a common cause of end-stage renal disease (ESRD) in children. Children who escape the newborn period with mild-to-moderate chronic kidney disease (CKD) continue to be at increased risk. The predictive ability of clinically available markers throughout childhood is poorly defined. METHODS: Patients with OU were identified in the Chronic Kidney Disease in Children Study. The primary outcome of interest was renal replacement therapy (RRT) (cases)...
October 13, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Carlos Moctezuma-Velazquez, Francesca Saffioti, Stephanie Tasayco-Huaman, Stefania Casu, Andrew Mason, Davide Roccarina, Victor Vargas, Jan-Erick Nilsson, Emmanuel Tsochatzis, Salvador Augustin, Aldo J Montano-Loza, Annalisa Berzigotti, Douglas Thorburn, Joan Genesca, Juan Gonzalez Abraldes
BACKGROUND: Baveno-VI guidelines recommend that patients with compensated cirrhosis with liver stiffness by transient elastography (LSM-TE) <20 kPa and platelets >150,000/mm3 do not need an esophagogastroduodenoscopy (EGD) to screen for varices, since the risk of having varices needing treatment (VNT) is <5%. It remains uncertain if this tool can be used in patients with cholestatic liver diseases (ChLDs): primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC)...
October 12, 2018: American Journal of Gastroenterology
Miguel Cainzos-Achirica, Cristina Enjuanes, Philip Greenland, John W McEvoy, Mary Cushman, Zeina Dardari, Khurram Nasir, Matthew J Budoff, Mouaz H Al-Mallah, Joseph Yeboah, Michael D Miedema, Roger S Blumenthal, Josep Comin-Colet, Michael J Blaha
BACKGROUND AND AIMS: We aimed to evaluate the associations and prognostic value of interleukin-6 (IL6) for the prediction of atherosclerotic cardiovascular disease (ASCVD) events, heart failure (HF), and other chronic diseases in a large, multi-ethnic, contemporary population. METHODS: We included 6617 participants from the Multi-Ethnic Study of Atherosclerosis (5640 non-users, 977 users of statins at baseline). Main outcomes were hard ASCVD events and HF; secondary outcomes included all-cause death, atrial fibrillation, venous thromboembolism and cancer...
October 4, 2018: Atherosclerosis
Waiel Al-Kahiry, Hadeel Said Tawfik, Homam Sharshira, Amal Ghanem, Maha El-Gammal, Irene Lewis Mikhael
Background: This study aimed to evaluate the prognostic value of smudge cell percentage as a surrogate marker for zeta-chain-associated protein kinase 70 (ZAP-70) expression in chronic lymphocytic leukemia (CLL) patients. Methods: Sixty three newly diagnosed CLL patients were investigated at the Hematology Department of the Medical Research Institute of Alexandria University with complete blood count, lactate dehydrogenase, β2 microglobulin levels, ZAP-70 expression, and estimation of the percentage of smudge cells...
September 2018: Blood Research
Monica Sharma, Seema Tyagi, Preeti Tripathi, Tulika Seth
Background: Syndecan-1 (sCD138) has recently been suggested to predict the clinical course of early-stage chronic lymphocytic leukemia (CLL), but few studies have been reported. This study assessed the role of syndecan-1 in the prognosis of patients with CLL and its correlation with other prognostic markers. Methods: This prospective study was performed in the hematology department of an Indian tertiary care center, over nineteen months (Jun. 2009-Jan. 2011). Forty-nine new patients with CLL presented during this period and were included...
September 2018: Blood Research
Suguru Ohira, Hiroaki Miyata, Sachiko Yamazaki, Satoshi Numata, Noboru Motomura, Shinichi Takamoto, Hitoshi Yaku
OBJECTIVES: Despite its survival benefits, bilateral internal thoracic artery (BITA) grafting is not commonly utilized due to concerns over deep sternal wound infection (DSWI). The present study investigated the early outcome of BITA grafting and analyzed the risk of DSWI using a Japanese national database (the Japan Adult Cardiovascular Surgery Database). METHODS: Data from 560 hospitals were used. Between April 2012 and December 2015, BITA was harvested in 14,249 patients, corresponding to 32...
September 7, 2018: Journal of Thoracic and Cardiovascular Surgery
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