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Predicting risk of chronic disease

Nicolás Martínez-Calle, Sarah Hartley, Matthew Ahearne, Benjamin Kasenda, Amy Beech, Helen Knight, Constantine Balotis, Ben Kennedy, Simon Wagner, Martin J S Dyer, Dean Smith, Andrew K McMillan, Fiona Miall, Mark Bishton, Christopher P Fox
Delayed lymphocyte and T-cell immune reconstitution following bendamustine-rituximab (BR) for indolent non-Hodgkin lymphoma (iNHL) has been described, but no information is available for chronic lymphocytic leukaemia (CLL). We present a population-based retrospective analysis of immune reconstitution and risk of infection following BR. Outcomes included timing/correlates of CD4+ recovery and risk of ≥grade 3 infections. Consecutively treated patients (1 April 2014 to 31 January 2017) were included (n = 295),with a median age of 65 years (range 33-92); 57% were 1st line treatments...
December 13, 2018: British Journal of Haematology
E Bouza, J Cobo, B Almirante
OBJECTIVE: Clostridium difficile infections have a high recurrence rate, which can complicate the prognosis of affected patients. It is therefore important to establish an early detection and an appropriate therapeutic strategy. The objective of this manuscript was to gather the opinion of an expert group about the predictive factors of poor progression, as well as when to use fidaxomicin in different groups of high-risk patients. METHODS: A scientific committee of three experts in infectious diseases reviewed the most recent literature on the management of C...
December 13, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Hiroshi Kado, Tetsuro Kusaba, Satoaki Matoba, Tsuguru Hatta, Keiichi Tamagaki
The lack of a decrease in nocturnal blood pressure is a risk factor for the progression of chronic kidney disease (CKD); however, it currently remains unknown whether it is a risk factor in normotensive CKD patients. We conducted a retrospective cohort study and enrolled 676 CKD patients who underwent ambulatory blood pressure monitoring (ABPM). According to their nocturnal blood pressure dipping pattern (>10%: dipper or <10%: non-dipper) and average 24-h systolic blood pressure (>130/80 mmHg: hypertension or <130/80 mmHg: normotension), patients were divided into four groups...
December 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Richard L Amdur, Harold I Feldman, Elizabeth A Dominic, Amanda H Anderson, Srinivasan Beddhu, Mahboob Rahman, Myles Wolf, Muredach Reilly, Akinlolu Ojo, Raymond R Townsend, Alan S Go, Jiang He, Dawei Xie, Sally Thompson, Matthew Budoff, Scott Kasner, Paul L Kimmel, John W Kusek, Dominic S Raj
RATIONALE & OBJECTIVE: Traditional risk estimates for atherosclerotic vascular disease (ASVD) and death may not perform optimally in the setting of chronic kidney disease (CKD). We sought to determine whether the addition of measures of inflammation and kidney function to traditional estimation tools improves prediction of these events in a diverse cohort of patients with CKD. STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: 2,399 Chronic Renal Insufficiency Cohort (CRIC) Study participants without a history of cardiovascular disease at study entry...
December 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Qian Wang, Dongmei Zheng, Jia Liu, Li Fang, Qiu Li
BACKGROUND: The atherogenic index of plasma showed to be related with some chronic disease like cardiovascular diseases and atherosclerosis. Body mass index which was commonly used in clinical practice is not an accurate index to predict non-alcoholic fatty liver disease. The aim of this study is to investigate the relationship between atherogenic index of plasma and non-alcoholic fatty liver disease in obese participants. METHODS: 538 obese subjects were included in this cross sectional study...
December 13, 2018: Lipids in Health and Disease
Alexandra Lenoir, Jean-William Fitting, Pedro-Manuel Marques-Vidal, Peter Vollenweider, Laurent P Nicod
BACKGROUND: Reduced lung function predicts increased mortality, but its prevalence may vary depending on definition considered, use of bronchodilation and applied reference values. We aimed to assess lung function abnormalities in Lausanne, Switzerland, and their association with clinical history. METHODS: In a general population sample, spirometry was performed and bronchodilation applied if the ratio forced expiratory volume in 1 s (FEV1) / forced vital capacity (FVC) or the FVC was below the lower limit of normal (LLN) according to Global Lung Function Initiative 2012 references...
December 13, 2018: Respiratory Research
Shotaro Hoi, Tomoaki Takata, Takaaki Sugihara, Ayami Ida, Masaya Ogawa, Yukari Mae, Satoko Fukuda, Chishio Munemura, Hajime Isomoto
BACKGROUND: Kidney size is associated with renal function, however it is not elucidated whether kidney size is a risk for the progression of chronic kidney disease. The aim of this study was to investigate the predictive value of morphological evaluation of kidney size by ultrasonography for the progression of renal dysfunction. METHODS: Morphological parameters including kidney length, volume, cortical thickness, and medullary thickness were measured by ultrasonography in 87 patients with chronic kidney disease, and adjusted by body size...
December 7, 2018: Journal of Clinical Medicine
Hanjo Ko, Julius I Ejiofor, Jessica E Rydingsward, James D Rawn, Jochen D Muehlschlegel, Kenneth B Christopher
OBJECTIVES: Functional status prior to coronary artery bypass graft surgery may be a risk factor for post-operative adverse events. We sought to examine the association between functional status in the 3 months prior to coronary artery bypass graft surgery and subsequent 180 day mortality. DESIGN, SETTING, AND PARTICIPANTS: We performed a single center retrospective cohort study in 718 adults who received coronary artery bypass graft surgery from 2002 to 2014. EXPOSURES: The exposure of interest was functional status determined within the 3 months preceding coronary artery bypass graft surgery...
2018: PloS One
Yun-Cheng Hsieh, Kuei-Chuan Lee, Ying-Wen Wang, Ying-Ying Yang, Ming-Chih Hou, Teh-Ia Huo, Han-Chieh Lin
BACKGROUND: The role of noninvasive liver fibrosis markers which were developed to evaluate the severity of chronic liver disease remains unclear in cirrhosis. AIMS: To evaluate the correlation between noninvasive markers and hemodynamic parameters and their prognostic performance in cirrhotic patients. METHODS: A total of 242 cirrhotic patients undergoing hemodynamic study were analyzed. The correlations between noninvasive models, including FIB-4, aspartate aminotransferase to platelet ratio index, cirrhosis discriminant score, Lok index, Goteborg University Cirrhosis Index, and albumin-bilirubin (ALBI) score and hemodynamic parameters were investigated, along with their predictive accuracy for short- and long-term survival...
2018: PloS One
Magdalena Freckmann, Alexander Seipp, Martin W Laass, Sibylle Koletzko, Martin Claßen, Antje Ballauff, Jenny Peplies, Antje Timmer
Objective: We describe school performance and experience in children with inflammatory bowel disease (IBD) across Germany and Austria. Predictors of compromised performance and satisfaction were evaluated to identify subgroups of increased risk. Design: This cross-sectional analysis was based on a postal survey in children aged 10-15 with Crohn's disease, ulcerative colitis or unclassified IBD and their families. Multivariate regression analysis was used to assess influential factors on parental satisfaction with school, attending advanced secondary education (ASE), having good marks and having to repeat a class...
2018: BMJ Open Gastroenterology
Ioanna Giannakou, Katerina Chatzidionysiou, Laurence S Magder, Noemi Györi, Ronald van Vollenhoven, Michelle A Petri
Objectives: The aim of this study is to identify prognostic factors of persistent disease activity and long quiescence in systemic lupus erythematosus (SLE). Methods: Patients enrolled in the Hopkins Lupus Cohort from 1987 to 2012, who attended at least three visits per year during 3 consecutive years following baseline and had available information on disease activity were included. Patterns of SLE disease activity over the 3-year period were defined as: persistent long quiescent (pLQ), persistent relapsing-remitting (pRR), persistent chronic active (pCA) and mixed based on Modified SLE Disease Activity Index (M-SLEDAI)...
2018: Lupus Science & Medicine
Liang Chen, Jun Zheng, Jianye Cai, Yusheng Jie, Yingcai Zhang, Hui Li, Tongyu Lu, Liying He, Cuicui Xiao, Kaining Zeng, Hongyuan Fu, Haibo Li, Bin Ouyang, Guihua Chen, Jia Yao, Jiao Gong, Yang Yang
BACKGROUND/AIMS: The age-bilirubin-international normalized ratio-creatinine (ABIC) score, which is a predictive model commonly used for alcoholic hepatitis, has not yet been studied in acute-on-chronic hepatitis B liver failure (HBV-ACLF). We aimed to investigate the predictive value of the ABIC score in patients with HBV-ACLF. METHODS: This retrospective study involved 398 patients diagnosed with HBV-ACLF, who were divided into a training cohort of 305 patients and a validation cohort of 93 patients...
2018: Cellular Physiology and Biochemistry
Karel Lábr, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Monika Špinarová, Ondřej Ludka, Jiří Jarkovský, Klára Benešová, Monika Goldbergová-Pávková, Růžena Lábrová
BACKGROUND/AIMS: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients...
December 7, 2018: Kidney & Blood Pressure Research
Han Ni, Soe Moe, Zay Soe, Kay Thi Myint, K Neelakantan Viswanathan
BACKGROUND: Several dual bronchodilator combinations of long-acting beta2 -agonist (LABA) and long-acting muscarinic antagonist (LAMA) have been approved for treatment of stable chronic obstructive pulmonary disease (COPD). The current GOLD (Global Initiative for Chronic Obstructive Lung Disease) recommendations suggest the use of LABA/LAMA combinations in people with group B COPD with persistent symptoms, group C COPD with further exacerbations on LAMA therapy alone and group D COPD with or without inhaled corticosteroids (ICS)...
December 11, 2018: Cochrane Database of Systematic Reviews
Francesco Menzella, Francesca Bertolini, Mirella Biava, Carla Galeone, Chiara Scelfo, Marco Caminati
Patients with severe asthma have a greater risk of asthma-related symptoms, morbidities, and exacerbations. Moreover, healthcare costs of patients with severe refractory asthma are at least 80% higher than those with stable asthma, mainly because of a higher use of healthcare resources and chronic side effects of oral corticosteroids (OCS). The advent of new promising biologicals provides a unique therapeutic option that could achieve asthma control without OCS. However, the increasing number of available molecules poses a new challenge: the identification and selection of the most appropriate treatment...
2018: Drugs in Context
Ji-Hoon Lee, MinA Park, SeoungWoo Han, Jae Joon Hwang, So Hee Park, So Young Park
Platelets play an important role in hemostasis, inflammation, and immunity. Mean platelet volume (MPV), considered a marker of platelet function and activation, is associated with increased morbidity and mortality in sepsis, coronary artery disease, and chronic inflammatory disease. However, the clinical characteristics and prognostic significance of MPV changes for patients with pneumonia in the intensive care unit (ICU) have not been investigated. This retrospective study was conducted using data from an operational database of patients admitted to a medical ICU between October 2010 and October 2017...
2018: PloS One
Seohyun Park, Chan Joo Lee, Misol Lee, Min-Uk Cha, Seong Yeong An, Ki Heon Nam, Jong Hyun Jhee, Hae-Ryong Yun, Hyoungnae Kim, Youn Kyung Kee, Jung Tak Park, Hyeon Chang Kim, Tae-Hyun Yoo, Shin-Wook Kang, Sungha Park, Seung Hyeok Han
The pathogenesis of hypertension is multifactorial in patients with chronic kidney disease (CKD). We explored the relative contribution of arterial stiffness and fluid overload to blood pressure (BP) in these patients. We evaluated 1531 patients from a prospective observational cohort study of high-risk patients with cardiovascular disease. BP, arterial stiffness, and volume status expressed as the extracellular water/total body water ratio (ECW/TBW) were measured by 24-h BP monitoring, pulse-wave velocity (PWV), and bioelectrical impedance analysis, respectively...
December 10, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
María E Rodríguez-Ortiz, Claudia Pontillo, Mariano Rodríguez, Petra Zürbig, Harald Mischak, Alberto Ortiz
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
December 10, 2018: Scientific Reports
Che-Rung Liu, Xi Li, Po-Lin Chan, Zhuang Hui, Ji-Dong Jia, Xiao-Chun Wang, Ying-Ru Lo, Nick Walsh
BACKGROUND AND AIM: Chronic hepatitis C is a major global health challenge. China has the world's largest burden of hepatitis C and related liver disease, with several groups having an increased risk of acquiring hepatitis C virus (HCV) infection. We undertook a systematic review in Chinese and English literature to determine the seroprevalence of anti-HCV among men who have sex with men (MSM), sex workers, people who use drugs (PWUD) and migrant workers in China. METHODS: We searched three Chinese databases (CNKI, Wanfang and Chongqing VIP Information) and four English databases (Pubmed, EMBASE, Global Health and CINAHL) for studies published between 2010-2015...
December 4, 2018: International Journal of Infectious Diseases: IJID
Yuji Oba, Edna Keeney, Namratta Ghatehorde, Sofia Dias
BACKGROUND: Long-acting bronchodilators such as long-acting β-agonist (LABA), long-acting muscarinic antagonist (LAMA), and LABA/inhaled corticosteroid (ICS) combinations have been used in people with moderate to severe chronic obstructive pulmonary disease (COPD) to control symptoms such as dyspnoea and cough, and prevent exacerbations. A number of LABA/LAMA combinations are now available for clinical use in COPD. However, it is not clear which group of above mentioned inhalers is most effective or if any specific formulation works better than the others within the same group or class...
December 3, 2018: Cochrane Database of Systematic Reviews
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