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predicting risk

Esmee M Reijnierse, Sjors Verlaan, Vivien K Pham, Wen Kwang Lim, Carel G M Meskers, Andrea B Maier
Background: Approximately 10% of older adults is annually admitted to a hospital. Hospitalisation is associated with a higher risk of falls and mortality after discharge. This study aimed to identify predictors at admission for falls and mortality three months post-discharge in hospitalised older patients. Methods: The EMPOWER study is an observational, prospective longitudinal inception cohort of 378 patients aged 70 years and older who were subsequently admitted to a tertiary hospital (the Netherlands)...
December 14, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Maria A C Wester Trejo, Oliver Floßmann, Kerstin W Westman, Peter Höglund, E Christiaan Hagen, Michael Walsh, Jan A Bruijn, David R W Jayne, Ingeborg M Bajema, Annelies E Berden
Objectives: To determine predictors of renal relapse and end-stage renal failure (ESRF) in patients with ANCA-associated vasculitis. Methods: Data from four European Vasculitis Society randomized controlled trials, conducted roughly simultaneously between 15 March 1995 and 30 September 2002, was pooled to determine predictors of long-term renal outcome. The respective trial inclusion criteria covered the entire spectrum of disease severity. Baseline predictors of time to first renal relapse and time to ESRF were assessed by competing events analysis and Cox proportional hazards regression...
January 1, 2019: Rheumatology
Homa K Ahmadzia, Jaclyn M Phillips, Andra H James, Madeline M Rice, Richard L Amdur
OBJECTIVE: There has been an appreciable rise in postpartum hemorrhage requiring blood transfusions in the United States. Our objective is to better define patients at greatest risk for peripartum transfusion at the time of cesarean in order to identify cases for early intervention and monitoring. METHODS: Our study is a secondary analysis of a retrospective cohort study. Cases of intraoperative and immediate postpartum blood transfusion among women undergoing cesarean delivery were identified...
2018: PloS One
Cláudio E T Parente, Antonio Azeredo, Renata E Vollú, Everaldo Zonta, Claudio E Azevedo-Silva, Elcia M S Brito, Lucy Seldin, João Paulo M Torres, Rodrigo O Meire, Olaf Malm
Our main goal was to investigate the potential accumulation of fluoroquinolones (FQs) in agricultural soils over extended periods of land use, predicting leaching and estimating risk quotients for soil microorganisms. Short to long-term of poultry litter fertilization (<1-30 years) were evaluated for enrofloxacin (ENR) and ciprofloxacin (CIP) input, in addition to the emergence of plasmid-mediated quinolone resistance (PMQR) genes. High FQs concentration (range 0.56-100 mg kg-1 ) were measured in poultry litter samples...
November 27, 2018: Chemosphere
Eva C Gregertsen, William Mandy, Natalie Kanakam, Stephanie Armstrong, Lucy Serpell
Understanding variables predicting drop-out or unfavourable outcome following treatment for anorexia nervosa (AN) may help to improve upon intervention efforts. However, the current literature has demonstrated sparse and inconsistent significant findings. The current systematic review and meta-analysis summarised the evidence base examining baseline predictors of drop-out and outcome in AN treatment. A literature search was conducted to identify research investigating predictors of drop-out and outcome in individuals treated for AN...
December 2, 2018: Psychiatry Research
Siu-Man Ng, Chi-Hung Yeung, Siyu Gao
PURPOSE: Although high expressed emotions (EE) is one of the most significant predictors for schizophrenic relapse, the assessment of EE is often impeded by the demanding Camberwell Family Interview (CFI) that is required to be conducted by specifically trained staff. To enable a more efficient assessment of EE, we developed the 12-item Concise Chinese Level of Expressed Emotion Scale (CCLEES) and reported its predictive and concurrent validity in this study. METHODS: A one-year prospective study design was adopted...
December 5, 2018: Comprehensive Psychiatry
Emily B Graham, James C Stegen, Maoyi Huang, Xingyuan Chen, Timothy D Scheibe
Global investment in hydropower is rapidly increasing, fueled by a need to manage water availability and by incentives promoting renewable energy sources. This expansion poses unrecognized risks to the world's vulnerable freshwater ecosystems. While many hydropower impacts have been investigated, dam-induced alterations to subsurface processes influence river corridor ecosystem health in ways that remain poorly understood. We advocate for a better understanding of dam impacts on subsurface biogeochemical activity, its connection to hydrology, and follow-on trophic cascades within the broader river corridor...
November 30, 2018: Science of the Total Environment
J'Neka S Claxton, Richard F MacLehose, Pamela L Lutsey, Faye L Norby, Lin Y Chen, Wesley T O'Neal, Alanna M Chamberlain, Lindsay G S Bengtson, Alvaro Alonso
BACKGROUND: Stroke risk stratification scores (e.g., CHA2 DS2 -VASc) are used to tailor therapeutic recommendations for patients with atrial fibrillation (AF) in different risk groups. OBJECTIVE: To develop a tool to estimate stroke risk in patients receiving oral anticoagulants (OACs) and to identify patients who remain at a high risk of stroke despite anticoagulation therapy. METHODS: Patients with non-valvular AF initiating OACs were identified in the MarketScan data from 2007-2015...
December 11, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Peter G Lawlor, Nicole A Rutkowski, Alistair R MacDonald, Mohammed T Ansari, Lindsey Sikora, Franco Momoli, Salmaan Kanji, David K Wright, Erin Rosenberg, Annmarie Hosie, Jose L Pereira, David Meagher, Jill Rice, John Scott, Shirley H Bush
CONTEXT: Based on the clinical care pathway of delirium in palliative care (PC), a published analytic framework (AF) formulated research questions in key domains and recommended a scoping review to identify evidence gaps. OBJECTIVES: To produce a literature map for key domains of the published AF: screening; prognosis and diagnosis; management and the health-related outcomes. METHODS: A standard scoping review framework was used by an interdisciplinary study team of nurse and physician delirium researchers, an information specialist and review methodologists to conduct the review...
December 11, 2018: Journal of Pain and Symptom Management
Mavis Machirori, Christine Patch, Alison Metcalfe
Within the field of breast cancer care, women concerned about their family history are offered genetic testing and subsequent treatment options based on several factors which include but are not limited to personal and family cancer disease histories and clinical guidelines. Discussions around decision-making in genetics in Black and Minority Ethnic (BME) groups are rarely documented in literature, and information regarding interactions with genetics services is usually discussed and linked to lack of scientific knowledge...
December 11, 2018: European Journal of Medical Genetics
Yuanjie Pang, Michael V Holmes, Zhengming Chen, Christiana Kartsonaki
We aimed to review the epidemiologic literature examining lifestyle, metabolic risk factors, and blood-based biomarkers including multi-omics (genomics, proteomics, and metabolomics) and to discuss how these predictive markers can inform early diagnosis of pancreatic ductal adenocarcinoma (PDAC). A search of the PubMed database was conducted in June 2018 to review epidemiologic studies of (1) lifestyle and metabolic risk factors for PDAC, genome-wide association studies (GWAS), and risk prediction models incorporating these factors and (2) blood-based biomarkers for PDAC (conventional diagnostic markers, metabolomics, and proteomics)...
December 14, 2018: Journal of Gastroenterology and Hepatology
Jae Yeong Cho, Kye Hun Kim, Hyun-Jai Cho, Hae-Young Lee, Jin-Oh Choi, Eun-Seok Jeon, Sang Eun Lee, Min-Seok Kim, Jae-Joong Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Youngkeun Ahn, Hyun-Young Park, Myeong-Chan Cho, Byung-Hee Oh
BACKGROUND: We investigated the role of nutritional risk index (NRI) in predicting 1-year mortality in patients with acute decompensated heart failure (ADHF). METHODS: Among 5,625 cohort patients enrolled in Korean Acute Heart Failure (KorAHF) Registry, a total of 5,265 patients who were possible to calculate NRI [NRI = (1.519 x serum albumin [g/dl]) + (41.7 x weight [kg]/ideal body weight [kg])] were enrolled. The patients were divided into 4 groups according to the NRI quartile; Q1 <89 (n = 1121, 69...
2018: PloS One
João Amaro, João Magalhães, Margarida Leite, Beatriz Aguiar, Paula Ponte, Joana Barrocas, Pedro Norton
INTRODUCTION: Healthcare workers account for 10% of the EU's total workforce, with a significant proportion of those employed in hospitals. Musculoskeletal injuries are the predominant group of injuries in healthcare professionals due to the physical demands of their work, such as the mobilization and positioning of the dependent patients. The management of this type of problem should take into account direct and indirect costs, such as periods of incapacity for work due to illness, hiring and training of new employees during periods of absence, reduced levels of productivity and the effects on production and quality of work...
2018: PloS One
You-Jun Wu, Yue Wang, Rong Qin, Zhi-Yu Cao, Hua-Zhou Zhao, Xiao-Hui Du, Bo Yang
BACKGROUND Serum alkaline phosphatase (ALP) has been proved to be a negative prognostic factor for several malignancies, but its clinical significance in gastric cancer (GC) patients has not been sufficiently studied. In the present retrospective study, we investigated the effect of serum ALP on disease-free survival (DFS) after radical gastrectomy. MATERIAL AND METHODS We included 491 GC patients receiving radical gastrectomy at the Chinese People's Liberation Army 309th Hospital. Univariate and multivariate analyses were performed to determine factors influencing serum ALP and DFS...
December 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Catherine C Peterson, Jessica Riggs, Katherine Guyon-Harris, Lauren Harrison, Alissa Huth-Bocks
OBJECTIVE: Intimate partner violence (IPV) can adversely affect children's cognitive development, but links between IPV exposure and language development in the earliest years of life remain unknown. The present study examined the effects of IPV and the quality of the home environment on children's language development at age 3 years. METHODS: In a prospective, 5-panel, longitudinal study of 79 mother-child dyads assessed prenatally to age 3 years, we examined standardized measures of receptive and expressive language development at age 3 years...
December 13, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
Daphne J Hill, Sarai Blanco Martinez, Yesenia Mejia, Andrea L Kulish, Alyson M Cavanaugh, Gabriela L Stein
OBJECTIVES: Latina mothers in emerging immigrant communities experience heightened risk for depressive symptoms because of the convergence of multiple risk factors rooted in economic, cultural, and familial experiences. Previous research with Latina/o adolescents has found that discrimination, and not acculturative stress, predicts depressive symptoms; however, no research to our knowledge has examined the relative impact of both discrimination and acculturative stress in Latina mothers...
December 13, 2018: Cultural Diversity & Ethnic Minority Psychology
Raviv Allon, Yahav Levy, Idit Lavi, Aviv Kramer, Menashe Barzilai, Ronit Wollstein
Because fragility fractures have an enormous impact on the practice of medicine and global health systems, effective screening is imperative. Currently, dual-energy X-ray absorptiometry (DXA), which has limited ability to predict fractures, is being used. We evaluated the current literature for a method that may constitute a better screening method to predict fragility fractures. A systematic review of the literature was conducted on computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound to evaluate screening methods to predict fragility fractures...
December 2018: Israel Medical Association Journal: IMAJ
Boye Li, Sisi Shen, Wenmei Zhang, Tingjuan Qi, Qin Hu, Yuan Cheng
<i>Background:</i> Emerging evidence suggests that long non-coding RNAs (lncRNAs) can be used as potential biomarkers for a wide range of cancers. Herein, the prognostic value of lncRNA taurine upregulated gene (TUG1) was analyzed using meta-analysis in different kinds of cancers. <i>Methods:</i> Databases including Cochrane Library, PubMed, and Chinese National Knowledge Infrastructure were searched for epidemiological studies up to March 2018. Hazard ratio (HR) and its 95% confidence interval (CI) were calculated to probe the relationship between TUG1 expression and overall survival of various cancer patients...
October 31, 2018: Clinical Laboratory
You Na Kim, Joong Won Shin, Kyung Rim Sung
PURPOSE: To investigate the relationship between the progression of visual field (VF) loss and changes in lamina cribrosa depth (LCD) as determined by spectral-domain optical coherence tomography (SD-OCT) enhanced depth imaging in patients with primary open angle glaucoma (POAG). METHODS: Data from 60 POAG patients (mean follow-up, 3.5 ± 0.7 years) were included in this retrospective study. The LCD was measured in the optic disc image using SD-OCT enhanced depth imaging scanning at each visit...
December 2018: Korean Journal of Ophthalmology: KJO
Guofeng Gao, Yanyan Zhao, Dong Zhang, Yuan He, Chenxi Song, Chenggang Zhu, Changdong Guan, Bo Xu, Dong Yin, Kefei Dou
OBJECTIVES: This study aimed to assess the risk stratification value of the SYNTAX Score II (SS II) in consecutive PCI patients and to analyze whether the predictive ability of SS II was consistent in patients with complex and non-complex coronary artery disease. BACKGROUND: SS II was designed for patients with complex coronary artery disease and has been validated by a number of studies in such patients. METHODS: The SS II for PCI was assessed in 10,072 consecutive patients who underwent PCI in Fuwai Hospital from January to December 2013...
December 14, 2018: Catheterization and Cardiovascular Interventions
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