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predicting risk

D Jančatová, K Zeleník, P Komínek, M Formánek
OBJECTIVE: There is currently no general consensus on patulous Eustachian tube management. Injection of autologous fat, cartilage or hydroxylapatite has been described for Eustachian tube occlusion, with promising results. However, complete resolution of symptoms is not achieved in all cases. This could be connected to the amount of material injected into the surroundings of the Eustachian tube, as this greatly differs among existing studies. Identifying the appropriate volume of injected material could be challenging because anatomical conditions vary among patients, and there is always a risk of chronic Eustachian tube obstruction and its related complications when too much long-standing material is injected...
October 16, 2018: Journal of Laryngology and Otology
(no author information available yet)
BACKGROUND: A body of empirical work demonstrates that wide fluctuations in a person's blood pressure across consecutive measures, known as blood pressure variability (BPV), hold prognostic value to predict stroke and transient ischemic attack. However, the magnitude of association between BPV and other neurological outcomes remains less clear. This systematic review aims to pool together data regarding BPV with respect to incident dementia, cognitive impairment, and cognitive function...
October 15, 2018: Systematic Reviews
Hiromasa Tanino, Tatsuya Sato, Yasuhiro Nishida, Ryo Mitsutake, Hiroshi Ito
BACKGROUND: Dislocation continues to be a common complication following total hip arthroplasty (THA). A larger intraoperative range of motion (ROM) is believed to minimize dislocation risk, and intraoperative stability tests have been used to assess the ROM. However, it is not clear whether or not intraoperative stability tests can predict hip stability after THA. It is also unclear which angles are required in intraoperative stability tests. We investigated the usefulness of intraoperative stability tests, and other risk factors to predict hip stability after THA...
October 15, 2018: BMC Musculoskeletal Disorders
Marta Sobas, Pau Montesinos, Blanca Boluda, Teresa Bernal, Edo Vellenga, Josep Nomdedeu, Jose González-Campos, Maria Chillón, Aleksandra Holowiecka, Jordi Esteve, Juan Bergua, José David González-Sanmiguel, Cristina Gil-Cortes, Mar Tormo, Olga Salamero, Felix Manso, Isolda Fernández, Javier de la Serna, María-José Moreno, Manuel Pérez-Encinas, Isabel Krsnik, Josep-Maria Ribera, Lourdes Escoda, Bob Lowenberg, Miguel Angel Sanz
Out of 956, there were 95 (10%) CD56+ APL patients treated with PETHEMA ATRA and chemotherapy. CD56+ expression was associated with high WBC, BCR3 isoform, and co-expression of CD2, CD34, CD7, HLA-DR, CD15, and CD117 antigens. CD56+ vs CD56- APL presented higher induction death rate (16% vs 8%, p = .02) and 5-years cumulative incidence of relapse (33% versus 10%, p = .006), irrespectively of the Sanz score (low-risk 47% versus 5%, p < .001; intermediate 23% versus 7%, p < .001; and high-risk 42% versus 21%, p = ...
October 15, 2018: Leukemia & Lymphoma
N Green, A Al-Allak, C Fowler
INTRODUCTION: Decisions regarding adjuvant chemotherapy in women with oestrogen receptor positive, human epidermal growth factor receptor 2 negative, node negative, early invasive breast cancer are unclear. The Recurrence Score® (RS) from Oncotype DX® (ODX) testing guides decisions based on individual cancer genomics. The aim of this study was to evaluate the impact of introducing ODX results on adjuvant treatment decisions and its potential economic benefits. METHODS: Patients offered the test were identified from the ODX requesting system...
October 16, 2018: Annals of the Royal College of Surgeons of England
Veysel Ozan Tanik, Tufan Cinar, Emre Arugaslan, Yavuz Karabag, Mert Ilker Hayiroglu, Metin Cagdas, Ibrahim Rencuzogullari, Mahmut Uluganyan
The PREdicting bleeding Complications In patients undergoing Stent implantation and subsEquent Dual Anti-Platelet Therapy (PRECISE-DAPT) score predicts the bleeding risk in patients treated with dual antiplatelet treatment after primary percutaneous coronary intervention (pPCI). This study aimed to determine the predictive value of the admission PRECISE-DAPT score for in-hospital mortality in patients with ST elevation myocardial infarction (STEMI) treated with pPCI. Of the 1418 patients enrolled, the study population was divided into 2 groups: PRECISE-DAPT score ≥25 and PRECISE-DAPT score <25...
October 15, 2018: Angiology
Siddharth Narasimhan Aiyer, Ajit Kumar, Ajoy Prasad Shetty, Rishi Mugesh Kanna, Shanmuganath Rajasekaran
Study Design: Prospective observational study. Purpose: To determine the incidence of postoperative urinary retention (POUR) in patients undergoing elective posterior lumbar spine surgery and identify the risk factors associated with the development of POUR. Overview of Literature: POUR following surgery can lead to detrusor dysfunction, urinary tract infections, prolonged hospital stay, and a higher treatment cost; however, the risk factors for POUR in spine surgery remain unclear...
October 16, 2018: Asian Spine Journal
Gerard Hoek, Andrea Ranzi, Ilir Alimehmeti, Elena-Roxana Ardeleanu, Juan P Arrebola, Paula Ávila, Carla Candeias, Ann Colles, Gloria Cerasela Crișan, Sarah Dack, Zoltán Demeter, Lucia Fazzo, Tine Fierens, Benjamin Flückiger, Stephanie Gaengler, Otto Hänninen, Hedi Harzia, Rupert Hough, Barna Laszlo Iantovics, Olga-Ioanna Kalantzi, Spyros P Karakitsios, Konstantinos C Markis, Piedad Martin-Olmedo, Elena Nechita, Thomai Nicoli, Hans Orru, Roberto Pasetto, Francisco Miguel Pérez-Carrascosa, Diogo Pestana, Fernando Rocha, Dimosthenis A Sarigiannis, João Paulo Teixeira, Christos Tsadilas, Visa Tasic, Lorenzo Vaccari, Ivano Iavarone, Kees de Hoogh
BACKGROUND: this paper is based upon work from COST Action ICSHNet. Health risks related to living close to industrially contaminated sites (ICSs) are a public concern. Toxicology-based risk assessment of single contaminants is the main approach to assess health risks, but epidemiological studies which investigate the relationships between exposure and health directly in the affected population have contributed important evidence. Limitations in exposure assessment have substantially contributed to uncertainty about associations found in epidemiological studies...
September 2018: Epidemiologia e Prevenzione
Farman Ali, Zujie Yao, Wanxin Li, Lina Sun, Wenxiong Lin, Xiangmin Lin
luxS is conserved in several bacterial species, including A. hydrophila, which causes infections in prawn, fish, and shrimp, and is consequently a great risk to the aquaculture industry and public health. luxS plays a critical role in the biosynthesis of the autoinducer-2 (AI-2), which performs wide-ranging functions in bacterial communication, and especially in quorum sensing (QS). The prediction of a 3D structure of the QS-associated LuxS protein is thus essential to better understand and control A. hydrophila pathogenecity...
October 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Francisca Dias, Mariana Morais, Ana Luísa Teixeira, Rui Medeiros
Esophageal cancer (EC) is the eighth most common and sixth leading cause of cancer-related mortality in the world. Despite breakthroughs in EC diagnosis and treatment, patients with complete pathologic response after being submitted to chemoradiotherapy are still submitted to surgery, despite its high morbidity. Single-nucleotide polymorphisms (SNPs) in miRNA, miRNA-binding sites, and in its biogenesis pathway genes can alter miRNA expression patterns, thereby influencing cancer risk and prognosis. In this review, we systematized the information available regarding the impact of these miR-SNPs in EC development and prognosis...
October 12, 2018: Cancers
R Faroug, O Bagshaw, L Conway, J S Ballester
BACKGROUND: Scarf osteotomy for hallux valgus is a successful procedure. Neverthless recurrence of deformity is reported as 5-8%. First ray instability is a recognised risk factor for recurrence. We investigate whether a radiographic marker such as Meary's line can be used to predict recurrence. This paper aims to test the null hypothesis that there is no difference in recurrence for mild and moderate hallux valgus treated with Scarf osteotomy in the presence of a disrupted Meary's line compared to an intact line...
June 26, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Yafei Tan, Dan Zhang, Hui Mei, Hong Mei, Zhengmin Qian, Katherine A Stamatakis, Savannah S Jordan, Yan Yang, Shaoping Yang, Bin Zhang
OBJECTIVE: The aim of this study was to determine whether specific perinatal factors are associated with obstructive sleep apnea syndrome (OSAS) in children. METHODS: A retrospective case-control study was conducted. All cases of OSAS were obtained from a tertiary pediatric hospital between April 2013 and April 2016. A total of 823 children who had been diagnosed with OSAS were designated as the case group, and 823 children without OSAS were selected with strict criteria to match with the case group by age, gender and body mass index...
September 17, 2018: Sleep Medicine
Alina I Esterhuizen, Heather C Mefford, Rajkumar S Ramesar, Shuyu Wang, Gemma L Carvill, Jo M Wilmshurst
PURPOSE: Dravet syndrome (DS) is a well-described, severe genetic epileptic encephalopathy with an increased risk of SUDEP. The incidence and genetic architecture of DS in African patients is virtually unknown, largely due to lack of awareness and unavailability of genetic testing. The clinical benefits of the available precision medicine approaches to treatment emphasise the importance of an early, correct diagnosis. We investigated the genetic causes and clinical features of DS in South African children to develop protocols for early, cost-effective diagnosis in the local setting...
September 14, 2018: Seizure: the Journal of the British Epilepsy Association
John P Prybylski, Carla Coste Sanchez, Michael Jay
OBJECTIVE: To determine if gadolinium (Gd) can be rechelated once released from Gd-based contrast agents (GBCAs) and deposited in vivo. Despite extensive research comparing GBCAs and GBCA formulations as well as the ongoing debate about their risks of deposition and the role of Gd release, it remains unknown if retained Gd can be eliminated by administering chelating agents. MATERIALS AND METHODS: Rats were injected intravenously with 10 doses of 1 mmol/kg gadodiamide and treated with intravenous Zn-DTPA (30 μmol/kg) concomitantly or 1, 4 or 8 h after GBCA administration (N = 3 rats per group)...
October 12, 2018: Magnetic Resonance Imaging
Riikka Immonen, Neil G Harris, David Wright, Leigh Johnston, Eppu Manninen, Gregory Smith, Afshin Paydar, Craig Branch, Olli Grohn
Posttraumatic epilepsy (PTE) is a major neurodegenerative disease accounting for 20% of symptomatic epilepsy cases. A long latent phase offers a potential window for prophylactic treatment strategies to prevent epilepsy onset, provided that the patients at risk can be identified. Some promising imaging biomarker candidates for posttraumatic epileptogenesis have been identified, but more are required to provide the specificity and sensitivity for accurate prediction. Experimental models and preclinical longitudinal, multimodal imaging studies allow follow-up of complex cascade of events initiated by traumatic brain injury, as well as monitoring of treatment effects...
October 12, 2018: Neurobiology of Disease
Eun Hee Kim, Hong-Kyu Kim, Sung-Jin Bae, Min Jung Lee, Jenie Yoonoo Hwang, Jaewon Choe, Chang Hee Jung, Woo Je Lee, Joong-Yeol Park
AIMS: Visceral fat accumulation is known to be an independent risk factor for type 2 diabetes. We aimed to determine the optimal cutoff values of visceral fat area (VFA) for predicting incident type 2 diabetes in Koreans. METHODS: Our study population consisted of 13,004 individuals initially free of type 2 diabetes the ages between 20 and 69 years, who underwent routine health examinations between January 2012 and December 2012 and returned for follow-up examinations between January 2016 and December 2016...
October 12, 2018: Diabetes Research and Clinical Practice
Chompunoot Wangboon, Chanika Worasith, Raynoo Thanan, Chatanun Eamudomkarn, Anchalee Techasen, Jiraporn Sithithaworn, Watcharin Loilome, Nittaya Chamadol, Somchai Pinlaor, Amonrat Jumnainsong, Puangrat Yongvanit, Narong Khuntikeo, Jeffrey M Bethony, Paiboon Sithithaworn
Inflammation of the hepatobiliary system in chronic opisthorchiasis is associated with an elevated level of urinary 8-oxo-7,8 dihydro-2'deoxyguanosine (8-oxodG) during active as well as past exposure to Opisthorchis viverrini infection. In this study, we evaluated the short-term effect of praziquantel treatment on hepatobiliary disease (HBD) using urinary 8-oxodG as an inflammatory marker in a cohort of residents in endemic areas of opisthorchiasis in Khon Kaen, Thailand. The HBD status in terms of periductal fibrosis (PDF) was determined by abdominal ultrasonography and O...
October 12, 2018: Acta Tropica
Amir Mokhtari, Jane M Van Doren
We used an agent-based modeling (ABM) framework and developed a mathematical model to explain the complex dynamics of microbial persistence and spread within a food facility and to aid risk managers in identifying effective mitigation options. The model explicitly considered personal hygiene practices by food handlers as well as their activities and simulated a spatially explicit dynamic system representing complex interaction patterns among food handlers, facility environment, and foods. To demonstrate the utility of the model in a decision-making context, we created a hypothetical case study and used it to compare different risk mitigation strategies for reducing contamination and spread of Listeria monocytogenes in a food facility...
October 15, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
Kristen N Pender, Elan C Hope, Kristen N Riddick
Linked fate, or connection to the Black community, may be a pathway to engagement in social justice action for Black liberation. The purpose of this study is to understand the role of racial identity on Black queer youths' orientation toward Black activism. We used hierarchical linear regression to examine relationships between dimensions of racial identity and Black activism orientation among 142 queer-identified youth. We found that racial centrality and racial ideologies predicted high-risk activism orientation...
October 15, 2018: Journal of Community Psychology
Sean P Ryan, Cary Politzer, Cynthia Green, Samuel Wellman, Michael Bolognesi, Thorsten Seyler
Malnutrition is not uncommon in arthroplasty patients, and hypoalbuminemia has been shown to be predictive of postoperative complications. The authors sought to compare albumin concentration with a global assessment of physical health, the American Society of Anesthesiologists (ASA) score, to further discriminate the importance of albumin in predicting postoperative complications. A cohort of 128,412 patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) were identified from 2005 to 2015 through use of the American College of Surgeons National Surgical Quality Improvement Program database...
October 15, 2018: Orthopedics
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