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https://www.readbyqxmd.com/read/30547500/-recommendations-from-a-panel-of-experts-on-the-usefulness-of-fidaxomicin-for-the-treatment-of-infections-caused-by-clostridium-difficile
#1
E Bouza, J Cobo, B Almirante
OBJECTIVE: Clostridium difficile infections have a high recurrence rate, which can complicate the prognosis of affected patients. It is therefore important to establish an early detection and an appropriate therapeutic strategy. The objective of this manuscript was to gather the opinion of an expert group about the predictive factors of poor progression, as well as when to use fidaxomicin in different groups of high-risk patients. METHODS: A scientific committee of three experts in infectious diseases reviewed the most recent literature on the management of C...
December 13, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/30547452/in-vitro-methods-for-assessing-nanoparticle-toxicity
#2
Dustin T Savage, J Zach Hilt, Thomas D Dziubla
As a consequence of their increase in annual production and widespread distribution in the environment, nanoparticles potentially pose a significant public health risk. The sought-after catalytic activity granted by their physiochemical properties doubles as a hazard to physiological processes following exposure through inhalation, oral, transdermal, subcutaneous, and intravenous uptake. Upon uptake into the body, their size, morphology, surface charge, coating, and chemical composition augment the response of biological systems to the materials and enhance their toxicity...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30547368/obinutuzumab-in-combination-with-chemotherapy-for-the-first-line-treatment-of-patients-with-advanced-follicular-lymphoma-an-evidence-review-group-evaluation-of-the-nice-single-technology-appraisal
#3
REVIEW
Frederick W Thielen, Nasuh C Büyükkaramikli, Rob Riemsma, Debra Fayter, Nigel Armstrong, Ching-Yun Wei, Vanesa Huertas Carrera, Kate Misso, Gill Worthy, Jos Kleijnen, Isaac Corro Ramos
The National Institute for Health and Care Excellence (NICE), as part of the institute's single technology appraisal (STA) process, invited the company that makes obinutuzumab (Roche Products Limited) to submit evidence of the clinical and cost effectiveness of the drug in combination with chemotherapy, with or without obinutuzumab as maintenance therapy for adult patients with untreated, advanced follicular lymphoma (FL) in the UK. Kleijnen Systematic Reviews Ltd (KSR), in collaboration with Erasmus University Rotterdam, was commissioned to act as the Evidence Review Group (ERG)...
December 13, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/30547356/functional-significance-of-channelopathy-gene-variants-in-unexplained-death
#4
REVIEW
Ivan Gando, Hua-Qian Yang, William A Coetzee
Determining the cause of unexplained death in all age groups, including infants, is a priority in forensic medicine. The triple risk model proposed for sudden infant death syndrome involves the intersection of three risks: (1) a critical developmental period in homeostatic control (2), exogenous stressors, and (3) a vulnerable infant. Even though sex and age factor into some forms of inherited arrhythmogenic deaths in young individuals and adults, more appropriate a dual-risk disease model for adults involves exogenous stressors and a vulnerable individual...
December 13, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/30547255/hypothesis-ubiquitous-circadian-disruption-can-cause-cancer
#5
Thomas C Erren, Philip Lewis
Circadian disruption (CD) was implicated in chains of cancer causation when the International Agency for Research on Cancer classified shift-work involving circadian disruption as probably carcinogenic in 2007. In the following decade, epidemiological studies into causal concepts associated with circadian disruption were inconclusive. Unappreciated complexity with an exclusive focus on shift-work, light-at-night, sleep, and melatonin in regard to circadian disruption may be accountable. With compelling non-epidemiological evidence, we posit that ubiquitous circadian disruption causes cancer and, moreover, that this is unexplored epidemiologically...
December 13, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/30547202/prediction-of-sorafenib-treatment-related-gene-expression-for-hepatocellular-carcinoma-preoperative-mri-and-histopathological-correlation
#6
Zhi Dong, Kun Huang, Bing Liao, Huasong Cai, Yu Dong, Mengqi Huang, Xiaoqi Zhou, Yingmei Jia, Ling Xu, Yanji Luo, Zi-Ping Li, Shi-Ting Feng
PURPOSE: To investigate the feasibility of prediction for targeted therapy-related gene expression in hepatocellular carcinoma (HCC) using preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: Ninety-one patients (81 men, mean age 53.9 ± 12 years) with solitary HCC who underwent preoperative enhanced MRI were retrospectively analyzed. Features including tumor size, signal homogeneity, tumor capsule, tumor margin, intratumoral vessels, peritumor enhancement, peritumor hypointensity, signal intensity ratio on DWI, T1 relaxation times, and the reduction rate between pre- and post-contrast enhancement images were assessed...
December 13, 2018: European Radiology
https://www.readbyqxmd.com/read/30547157/development-of-a-medicare-health-outcomes-survey-deficit-accumulation-frailty-index-and-its-application-to-older-patients-with-newly-diagnosed-multiple-myeloma
#7
Hira S Mian, Tanya M Wildes, Mark A Fiala
Purpose: To develop a frailty index using the Rockwood Accumulation of Deficits approach for the Medicare Health Outcomes Survey (MHOS) and apply it in a subset of older patients with newly diagnosed multiple myeloma. Methods: Data from 2,692,361 patients without cancer, > 66 years of age, in SEER-MHOS linked databases between 1998 and 2009 were analyzed. A frailty index was constructed, resulting in a 25-item scale; cutoff values were created for individuals classified as frail...
2018: JCO Clinical Cancer Informatics
https://www.readbyqxmd.com/read/30547048/barcoding-of-macaque-hematopoietic-stem-and-progenitor-cells-a-robust-platform-to-assess-vector-genotoxicity
#8
Idalia M Yabe, Lauren L Truitt, Diego A Espinoza, Chuanfeng Wu, Samson Koelle, Sandhya Panch, Marcus A F Corat, Thomas Winkler, Kyung-Rok Yu, So Gun Hong, Aylin Bonifacino, Allen Krouse, Mark Metzger, Robert E Donahue, Cynthia E Dunbar
Gene therapies using integrating retrovirus vectors to modify hematopoietic stem and progenitor cells have shown great promise for the treatment of immune system and hematologic diseases. However, activation of proto-oncogenes via insertional mutagenesis has resulted in the development of leukemia. We have utilized cellular bar coding to investigate the impact of different vector designs on the clonal behavior of hematopoietic stem and progenitor cells (HSPCs) during in vivo expansion, as a quantitative surrogate assay for genotoxicity in a non-human primate model with high relevance for human biology...
December 14, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/30546938/genetic-associations-of-t-cell-cancer-immune-response-with-tumor-aggressiveness-in-localized-prostate-cancer-patients-and-disease-reclassification-in-an-active-surveillance-cohort
#9
Qinchuan Wang, Justin R Gregg, Jian Gu, Yuanqing Ye, David W Chang, John W Davis, Timothy C Thompson, Jeri Kim, Christopher J Logothetis, Xifeng Wu
Determining prostate cancer (PCa) aggressiveness and reclassification are critical events during the treatment of localized disease and for patients undergoing active surveillance (AS). Since T cells play major roles in cancer surveillance and elimination, we aimed to identify genetic biomarkers related to T cell cancer immune response which are predictive of aggressiveness and reclassification risks in localized PCa. The genotypes of 3,586 single nucleotide polymorphisms (SNPs) from T cell cancer immune response pathways were analyzed in 1762 patients with localized disease and 393 who elected AS...
2019: Oncoimmunology
https://www.readbyqxmd.com/read/30546904/a-novel-prognostic-prediction-model-for-recurrence-in-patients-with-stage-ii-colon-cancer-after-curative-resection
#10
Kazuhiro Saso, Norikatsu Myoshi, Shiki Fujino, Yuya Takenaka, Yusuke Takahashi, Junichi Nishimura, Masayoshi Yasui, Masayuki Ohue, Masayoshi Tokuoka, Yoshito Ide, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori
The present study aimed to clarify the risk factors for recurrence of stage II colon cancer in patients and to determine possible treatment options for postoperative adjuvant chemotherapy. A prediction model for recurrence in patients with stage II colon cancer after curative surgical resection was developed. The present study retrospectively investigated 436 patients who underwent curative resection for stage II colon cancer at Osaka International Cancer Institute and Yao Municipal Hospital between 2004 and 2012...
December 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30546892/evaluation-of-neutrophil-to-lymphocyte-ratio-and-calcitonin-concentration-for-predicting-lymph-node-metastasis-and-distant-metastasis-in-patients-with-medullary-thyroid-cancer
#11
Nizhen Xu, Yanbing Jian, Yaxi Wang, Wen Tian
The aim of the present study was to investigate potential predictive factors of lymph node metastasis (LNM) and distant metastasis (DM) of medullary thyroid cancer (MTC). A total of 61 patients newly diagnosed with MTC at the General Hospital of the Chinese People's Liberation Army between January 2001 and January 2016 were enrolled and divided into two groups according to the results of preoperative examinations and surgical histopathology as follows: Group NM (without metastases), and group M (with metastases)...
December 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30546880/predictive-value-of-combining-the-level-of-lipoprotein-associated-phospholipase-a2-and-antithrombin-iii-for-acute-coronary-syndrome-risk
#12
Jinyang Lu, Dandan Niu, Di Zheng, Quan Zhang, Wenhua Li
The aim of the present study was to observe the role of lipoprotein-associated phospholipase A2 (Lp-PLA2) and antithrombin III (AT-III) in patients with acute coronary syndrome (ACS), and the combination of Global Registry of Acute Coronary Events (GRACE) score to determine the value of coronary heart disease risk stratification. A total of 309 patients admitted to the Affiliated Hospital of Xuzhou Medical University were enrolled. The patients were divided into two groups: The ACS (183 cases) and control (126 cases) groups...
December 2018: Biomedical Reports
https://www.readbyqxmd.com/read/30546346/diabetic-and-elder-patients-experience-superior-cardiovascular-benefits-after-gastric-bypass-induced-weight-loss
#13
Pedro R Pereira, Marta Guimarães, Tiago Morais, Sofia S Pereira, Mário Nora, Mariana P Monteiro
Background/Objetives: Obesity and obesity related co-morbidities are well-recognized risks for cardiovascular (CV) disease and mortality. Weight loss improves CV risk factors and the efficacy of bariatric surgery in decreasing CV mortality is now well-established. Our aim was to assess CV risk progression and occurrence of CV events in a cohort of patients that underwent Roux-en-Y gastric bypass (RYGB) for obesity treatment in a single academic public center. Subjects and Methods: Ten year CV risk was estimated using the Framingham Equation at baseline and 2 years after RYGB surgery in our patients cohort ( n = 260)...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30546282/effect-of-national-implementation-of-telephone-cpr-program-to-improve-outcomes-from-out-of-hospital-cardiac-arrest-an-interrupted-time-series-analysis
#14
Yu Jin Lee, Seung-Sik Hwang, Sang Do Shin, Seung Chul Lee, Kyoung Jun Song
Background: In cardiac arrest, the survival rate increases with the provision of bystander cardiopulmonary resuscitation (CPR), of which the initial response and treatment are critical. Telephone CPR is among the effective methods that might increase the provision of bystander CPR. This study aimed to describe and examine the improvement of neurological outcomes in individuals with out-of-hospital acute cardiac arrest by implementing the nationwide, standardized telephone CPR program...
December 17, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/30546238/the-predictivity-of-mandibular-third-molar-position-as-a-risk-indicator-for-pericoronitis-a-prospective-study
#15
Preeti Singh, Priyanka Nath, Sukhvinder Bindra, Sadam Srinivasa Rao, K V Ramana Reddy
Aim: The aim of this study was to describe the characteristics of the mandibular third molar at highest risk for acute pericoronitis using clinical and radiographic analysis. Materials and Methods: A total of 120 patients ranging in age from 18 to 55 years suffering from pericoronitis were examined. Subjective and objective observations were recorded that included the age, gender, angulation of partially impacted mandibular third molar, the frequency of pericoronitis in a year, the presence of impinging maxillary third molar, the extent of soft tissue coverage over the impacted mandibular third molar, the clinical signs evaluated in the patient, the class and position of the impacted mandibular third molar, and the presence of distal radiolucency with respect to the impacted mandibular third molar...
July 2018: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/30546196/life-history-changes-in-the-cold-tolerance-of-the-two-spot-spider-mite-tetranychus-urticae-applications-in-pest-control-and-establishment-risk-assessment
#16
Nicola White, Jeffrey S Bale, Scott A L Hayward
Lethal time50 (LTime50 ) and lethal temp (LTemp50 ) are commonly used laboratory indices of arthropod cold tolerance, with the former often being employed to predict winter survival in the field. In the present study, we compare the cold tolerance of different life-history stages (nondiapausing and diapausing females, as well as males and juveniles) of a major agricultural pest: the two-spot spider mite Tetranychus urticae Koch (Acarina: Tetranychidae). Diapausing females from European populations of this species are shown to be freeze avoiding, supercooling to -23...
December 2018: Physiological Entomology
https://www.readbyqxmd.com/read/30546124/determinants-of-environmental-styrene-exposure-in-gulf-coast-residents
#17
Emily J Werder, Dale P Sandler, David B Richardson, Michael E Emch, Richard K Kwok, Lawrence S Engel
BACKGROUND: In a previous study of exposure to oil-related chemicals in Gulf coast residents, we measured blood levels of volatile organic compounds. Levels of styrene were substantially elevated compared to a nationally representative sample. We sought to identify factors contributing to these levels, given the opportunities for styrene exposure in this community. METHODS: We measured blood styrene levels in 667 Gulf coast residents and compared participants' levels of blood styrene to a nationally representative sample...
December 13, 2018: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/30546105/normotensive-non-dipping-blood-pressure-profile-does-not-predict-the-risk-of-chronic-kidney-disease-progression
#18
Hiroshi Kado, Tetsuro Kusaba, Satoaki Matoba, Tsuguru Hatta, Keiichi Tamagaki
The lack of a decrease in nocturnal blood pressure is a risk factor for the progression of chronic kidney disease (CKD); however, it currently remains unknown whether it is a risk factor in normotensive CKD patients. We conducted a retrospective cohort study and enrolled 676 CKD patients who underwent ambulatory blood pressure monitoring (ABPM). According to their nocturnal blood pressure dipping pattern (>10%: dipper or <10%: non-dipper) and average 24-h systolic blood pressure (>130/80 mmHg: hypertension or <130/80 mmHg: normotension), patients were divided into four groups...
December 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30546085/development-of-a-newborn-screening-tool-based-on-bivariate-normal-limits-using-psychosine-and-galactocerebrosidase-determination-on-dried-blood-spots-to-predict-krabbe-disease
#19
Thomas J Langan, Joseph J Orsini, Kabir Jalal, Amy L Barczykowski, Maria L Escolar, Michele D Poe, Chad K Biski, Randy L Carter
PURPOSE: Newborn screening for Krabbe disease (KD) originated in New York State in 2006 but has proven to have a high false positive rate and low positive predictive value. To improve accuracy of presymptomatic prediction, we propose a screening tool based on two biomarkers, psychosine and galactocerebrosidase enzyme activity (GalC). METHODS: We developed the tool using measures from dried blood spots of 166 normal newborns and tested it on dried blood spot measures from 15 newborns who later developed KD, 8 newborns identified as "high risk" by the New York screening protocol but were disease-free at follow-up, and 3 symptomatic children with onset before 4 years of age...
December 14, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/30546084/27-years-of-prenatal-diagnosis-for-huntington-disease-in-the-united-kingdom
#20
Raul E Piña-Aguilar, Sheila A Simpson, Abdulrahman Alshatti, Angus Clarke, David Craufurd, Huw Dorkins, Karen Doye, Nayana Lahiri, Alison Lashwood, Colleen Lynch, Claire Miller, Sally Morton, Mary O'Driscoll, Oliver W Quarrell, Daniela Rae, Mark Strong, Charlotte Tomlinson, Peter Turnpenny, Zosia Miedzybrodzka
PURPOSE: There is little long-term, population-based data on uptake of prenatal diagnosis for Huntington disease (HD), a late-onset autosomal dominant neurodegenerative disorder, and the effect of the availability of preimplantation genetic diagnosis (PGD) on families' decisions about conventional prenatal diagnosis is not known. We report trends in prenatal diagnosis and preimplantation diagnosis for HD in the United Kingdom since services commenced. METHODS: Long-term UK-wide prospective case record-based service evaluation in 23 UK Regional Genetic Centres 1988-2015, and four UK PGD centers 2002-2015...
December 14, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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