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Chao Xing, Zhengzhai Cai, Jian Gong, Jun Zhou, Jingjing Xu, Feng Guo
BACKGROUND: Gastric cancer is one of the most common malignant tumors worldwide. Increasing studies have indicated that non-coding RNAs (ncRNAs) play critical roles in cancer progression. They have shown great potential to be useful markers and therapeutic targets. METHODS: Bioinformatics analysis was conducted to detect mRNA and ncRNAs' expression changes between tumor samples and adjacent non-tumor samples. The gene expression profiles were obtained from the national center of biotechnology information gene expression omnibus (GEO)...
October 1, 2018: Clinical Laboratory
Catherine M Worsley, Elizabeth S Mayne
BACKGROUND: Suitable laboratory testing prior to transplantation ensures that a patient's immunological risk is understood and allows the transplantation team to make the correct decisions on donor-recipient pairing. Preformed donor-specific anti-HLA antibodies mediate rejection in transplanted patients. Improved laboratory testing is needed to increase the chances of successful organ allocation. In this study, we show how Luminex™ single antigen assays are vital in determining immunological risk to transplantation and in predicting waiting time to transplantation...
October 1, 2018: Clinical Laboratory
Tibor Hortobágyi, Azusa Uematsu, Lianne Sanders, Reinhold Kliegl, József Tollár, Renato Moraes, Urs Granacher
BACKGROUND: Dynamic balance keeps the vertical projection of the center of mass within the base of support while walking. Dynamic balance tests are used to predict the risks of falls and eventual falls. The psychometric properties of most dynamic balance tests are unsatisfactory and do not comprise an actual loss of balance while walking. OBJECTIVES: Using beam walking distance as a measure of dynamic balance, the BEAM consortium will determine the psychometric properties, lifespan and patient reference values, the relationship with selected "dynamic balance tests," and the accuracy of beam walking distance to predict falls...
October 18, 2018: Gerontology
Fiorenzo Laghi, Dora Bianchi, Sara Pompili, Antonia Lonigro, Roberto Baiocco
Binge drinking during adolescence is influenced by peer pressure and group norms as risk factors. Conversely, drinking refusal self-efficacy is a protective factor. Thus, adolescents with impaired social skills could be more vulnerable to binge drinking. However, there is still little research on impaired social abilities, such as low empathy, in adolescent binge drinkers. This study aimed to investigate the moderating roles of empathic concerns and perspective-taking in the relationship between self-efficacy in resisting peer pressure to drink (SRPPD) and binge drinking...
October 11, 2018: Addictive Behaviors
Roberta Ledda, Gemma Battagliese, Fabio Attilia, Claudia Rotondo, Fabiola Pisciotta, Simona Gencarelli, Antonio Greco, Marco Fiore, Mauro Ceccanti, Maria Luisa Attilia
The Obsessive Compulsive Drinking Scale (OCDS) was developed to reflect obsessionality and compulsivity related to craving and drinking behaviour for revealing in the long-term drop-out, abstinence and relapse. This study evaluates the early OCDS predictive value in drop-out, abstinence and relapse of patients suffering from Alcohol Use Disorders (AUD) for discovering an OCDS total score cut-off capable of disclosing patients most at-risk of relapse during the beginning of the therapeutic intervention in the Day-Hospital period...
October 15, 2018: Physiology & Behavior
Yosuke Iyama, Hideyuki Sato, Yoshiki Seto, Satomi Onoue
This study aimed to verify the applicability of a proposed photosafety screening system based on a reactive oxygen species (ROS) assay and a cassette-dosing pharmacokinetic (PK) study to chemicals with wide structural diversity. The orally taken chemicals, erythromycin (ETM), gatifloxacin (GFX), 8-methoxypsoralen (MOP), pirfenidone (PFD), trifluoperazine (TFP), and voriconazole (VRZ), were selected as test compounds. The ROS assay was conducted to evaluate their photoreactivity, and all test compounds excluding ETM generated significant ROS under simulated sunlight exposure...
October 15, 2018: Journal of Pharmaceutical Sciences
A C M Simon, Horacio D Lopez-Nicora, Terry L Niblack, Elizabeth A Dayton, David Tomashefski, Pierce A Paul
Ten morphological groups of plant-parasitic nematodes (spiral, lesion, lance, dagger, stunt, pin, ring, stubby-root, cyst, and miscellaneous tylenchids) were detected in corn fields in Ohio, but the presence and population density of these groups varied among fields. Binary and ordinal logistic regression models were fitted to the data to estimate the odds of each group being present, and the lesion, lance, spiral, and pin nematode population densities being at moderate-high risk levels based on soil region, cropping sequence, tillage, and soil pH, silt content, and electrical conductivity...
October 18, 2018: Plant Disease
Fuqiang Yin, Shang Yi, Luwei Wei, Bingbing Zhao, Jinqian Li, Xiangxue Cai, Caihua Dong, Xia Liu
The outcome for patients with ovarian cancer (OC) is poor because of drug resistance. Therefore, identification of factors that affect drug resistance and prognosis in OC is needed. In the present study, we identified 131 genes significantly dysregulated in 90 platinum-resistant OC tissues compared with 197 sensitive tissues, of which 30 were significantly associated with disease-free survival (DFS; n = 16), overall survival (OS; n = 6), or both (n = 8) in 489 OC patients of the The Cancer Genome Atlas cohort...
October 18, 2018: Journal of Cellular Biochemistry
Ping-I Lin, Lin Fei, Drew Barzman, M Hossain
Little is known regarding the time trend of mass shootings and associated risk factors. In the current study, we intended to explore the time trend and relevant risk factors for mass shootings in the U.S. We attempted to identify factors associated with incidence rates of mass shootings at the population level. We evaluated if state-level gun ownership rate, serious mental illness rate, poverty percentage, and gun law permissiveness could predict the state-level mass shooting rate, using the Bayesian zero-inflated Poisson regression model...
2018: PloS One
Heng-Cheng Hsu, Yi-Jou Tai, Yu-Li Chen, Ying-Cheng Chiang, Chi-An Chen, Wen-Fang Cheng
We aimed to identify factors predicting parametrial invasion in early-stage cervical cancer patients undergoing radical hysterectomy. We recruited women with invasive cervical cancer who underwent radical hysterectomy at a single medical institute from 2000-2011. The clinical and pathological characteristics and outcomes were retrospectively recorded, and the risk factors for parametrial invasion were analyzed. We enrolled 339 patients, including 7 with stage IA1 carcinomas, 10 with stage IA2, 266 with stage IB1, 39 with stage IB2, 14 with stage IIA1, and 3 with stage IIA2...
2018: PloS One
M Oellerich, E Schütz, J Beck, P D Walson
Genomic analyses in oncologic care allow for the development of more precise clinical laboratory tests that will be critical for personalized pharmacotherapy. Traditional biopsy-based approaches are limited by the availability of sequential tissue specimens to detect resistance. Blood-based genomic profiling ("liquid biopsy") is useful for longitudinal monitoring of tumor genomes and can complement biopsies. Tumor-associated mutations can be identified in cell-free tumor DNA (ctDNA) from patient blood samples and used for monitoring disease activity...
October 16, 2018: Therapeutic Drug Monitoring
Hazuki Komuro, Jun Shigemura, Sayuri Uchino, Sho Takahashi, Masanori Nagamine, Masaaki Tanichi, Taku Saito, Hiroyuki Toda, Mie Kurosawa, Kazumi Kubota, Toshihiro Misumi, Yoshitomo Takahashi, Satomi Takahashi, Soichiro Nomura, Kunio Shimizu, Aihide Yoshino, Takeshi Tanigawa
OBJECTIVES: To predict increased alcohol and tobacco use in Fukushima nuclear power plant (NPP) workers three years after a nuclear disaster. METHODS: Surveys were conducted in two post-disaster waves (Wave 1: 2-3 months; Wave 2: 32 months). Adjusted risk ratio [aRR] was computed to assess the covariates of increased alcohol and tobacco use in Wave 2. RESULTS: Increased alcohol use was associated with age ≤29 years (aRR [95%CI]: 1.26 [1...
October 17, 2018: Journal of Occupational and Environmental Medicine
Ian H Stanley, Joseph W Boffa, Megan L Rogers, Melanie A Hom, Brian J Albanese, Carol Chu, Daniel W Capron, N Brad Schmidt, Thomas E Joiner
OBJECTIVE: Suicide is a global public health concern. To inform the prevention and treatment of suicidality, it is crucial to identify transdiagnostic vulnerability factors for suicide and suicide-related conditions. One candidate factor is anxiety sensitivity (AS)-the fear of anxiety-related sensations-which has been implicated in the pathogenesis of a host of mental health outcomes, including suicidal thoughts and behaviors. Importantly, AS is distinct from trait anxiety and negative affectivity, highlighting its potential incremental utility in the understanding of psychopathology...
November 2018: Journal of Consulting and Clinical Psychology
Terri Scott, Shelley L Brown
OBJECTIVE: Debate ensues regarding female-specific risk and strength factors among adolescent offenders. Using meta-analysis, we examined whether risk and strength factors predicted recidivism differentially between male and female youth. METHOD: Database searches identified 22 studies, representing 50,601 justice-involved youth (11,952 females and 38,649 males) and a total of 584 effect sizes. RESULTS: For the global risk domains, there is some evidence for gender neutrality (i...
November 2018: Journal of Consulting and Clinical Psychology
Bryan W Heckman, Jennifer Dahne, Lisa J Germeroth, Amanda R Mathew, Elizabeth J Santa Ana, Michael E Saladin, Matthew J Carpenter
OBJECTIVE: Long-term abstinence can be undermined by cessation fatigue-an exhaustion of coping resources attributable to quitting smoking/staying quit. The current study examines the predictive validity of a Cessation Fatigue Scale (CFS; three subscales). Among current smokers, we hypothesized higher fatigue would predict longer latency to both quit initiation and achieving 7-day point prevalence abstinence (7-day PPA). Among recent quitters, we expected higher cessation fatigue would confer greater lapse/relapse risk...
November 2018: Journal of Consulting and Clinical Psychology
Andrew J Petkus, J Vincent Filoteo, Dawn M Schiehser, Megan E Gomez, Giselle Petzinger
OBJECTIVE: Symptoms of anxiety, depression commonly co-occur with cognitive decline in patients with Parkinson's disease (PD). The directionality of this association is unclear, however, in that poor cognitive performance may lead to increased symptoms of anxiety and depression or higher anxiety and depressive symptoms may lead to cognitive decline. The purpose of this study was to elucidate the directionality of the association between symptoms of anxiety and depression with cognitive performance in newly diagnosed patients with PD...
October 18, 2018: Neuropsychology
Yuan Chen, Rui Zhu, Fang Ma, Jialin Mao, Eugene C Chen, Edna Choo, Srikumar Sahasranaman, Lichuan Liu
GDC-0810 was under development as an oral anti-cancer drug for the treatment of estrogen receptor-positive breast cancer as a single agent or in combination. In vitro data indicated that GDC-0810 is a potent inhibitor of OATP1B1/1B3. To assess clinical risk, PBPK model was developed to predict the transporter drug-drug interaction (tDDI) between GDC-0810 and pravastatin in human. The PBPK model was constructed in Simcyp® by integrating in vitro and in vivo data for GDC-0810. The prediction of human pharmacokinetics (PK) was verified using GDC-0810 phase I clinical PK data...
October 18, 2018: Biopharmaceutics & Drug Disposition
Joshua D Niznik, Song Zhang, Maria K Mor, Xinhua Zhao, Mary Ersek, Sherrie L Aspinall, Walid F Gellad, Joshua M Thorpe, Joseph T Hanlon, Loren J Schleiden, Sydney Springer, Carolyn T Thorpe
OBJECTIVES: To evaluate the predictive validity of an adapted version of the Minimum Data Set (MDS) Mortality Risk Index-Revised (MMRI-R) based on MDS version 3.0 assessment items (MMRI-v3) and to compare the predictive validity of the MMRI-v3 with that of a single MDS item indicating limited life expectancy (LLE). DESIGN: Retrospective, cross-sectional study of MDS assessments. Other data sources included the Veterans Affairs (VA) Residential History File and Vital Status File...
October 18, 2018: Journal of the American Geriatrics Society
Pierre-Grégoire Guinot, Julien Marc, Bruno de Broca, Thomas Archange, Stéphane Bar, Osama Abou-Arab, Hervé Dupont, Marc-Olivier Fischer, Emmanuel Lorne
This study was designed to assess the association between volume of fluid challenge (FC) and predictability of respiratory variation of stroke volume (ΔrespSV) in the operating theater.Patients undergoing intermediate/high-risk surgery and monitored by esophageal Doppler monitoring (EDM) were prospectively included. All patients were under general anesthesia and mechanically ventilated. Exclusion criteria were frequent ectopic beats or preoperative arrhythmia, right ventricular failure, and spontaneous breathing...
October 2018: Medicine (Baltimore)
Fabio Fabbian, Alfredo De Giorgi, Benedetta Boari, Elisa Misurati, Massimo Gallerani, Rosaria Cappadona, Rosario Cultrera, Roberto Manfredini, Maria A Rodrìguez Borrego, Pablo J Lopez-Soto
Infectious diseases (ID) are frequently cause of internal medicine wards (IMW) admission. We aimed to evaluate risk factors for in-hospital mortality (IHM) in IMW patients with ID, and to test the usefulness of a comorbidity score (CS).This study included ID hospital admissions between January 2013, and December 2016, recorded in the database of the local hospital. ICD-9-CM codes were selected to identify infections, development of sepsis, and to calculate a CS.We analyzed 12,173 records, (age 64.8 ± 25...
October 2018: Medicine (Baltimore)
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