Read by QxMD icon Read

Measurement-based psychiatry

Sofian Berrouiguet, David Ramírez, María Luisa Barrigón, Pablo Moreno-Muñoz, Rodrigo Carmona Camacho, Enrique Baca-García, Antonio Artés-Rodríguez
BACKGROUND: The emergence of smartphones, wearable sensor technologies, and smart homes allows the nonintrusive collection of activity data. Thus, health-related events, such as activities of daily living (ADLs; eg, mobility patterns, feeding, sleeping, ...) can be captured without patients' active participation. We designed a system to detect changes in the mobility patterns based on the smartphone's native sensors and advanced machine learning and signal processing techniques. OBJECTIVE: The principal objective of this work is to assess the feasibility of detecting mobility pattern changes in a sample of outpatients with depression using the smartphone's sensors...
December 10, 2018: JMIR MHealth and UHealth
Yena Lee, Mehala Subramaniapillai, Elisa Brietzke, Rodrigo B Mansur, Roger C Ho, Samantha J Yim, Roger S McIntyre
The etiology of mood disorders is mechanistically heterogeneous, underscoring the need for a dimensional approach to identify and develop targeted treatments in psychiatry. Accumulating evidence implicates inflammation as an important contributor to the pathophysiology of depression and presents the immune system as a viable therapeutic target that may be more proximate to the pathogenic nexus of brain-based disorders in specific subpopulations. Anhedonia is a transdiagnostic (e.g. Parkinson's disease, diabetes mellitus, rheumatic diseases), yet specific, and clinically relevant symptom dimension subserved by well-characterized neurobiological and neurophysiological substrates of the positive valence systems (PVS)...
December 2018: Therapeutic Advances in Psychopharmacology
Antje A T S Reinders, Andre F Marquand, Yolanda R Schlumpf, Sima Chalavi, Eline M Vissia, Ellert R S Nijenhuis, Paola Dazzan, Lutz Jäncke, Dick J Veltman
BACKGROUND: A diagnosis of dissociative identity disorder (DID) is controversial and prone to under- and misdiagnosis. From the moment of seeking treatment for symptoms to the time of an accurate diagnosis of DID individuals received an average of four prior other diagnoses and spent 7 years, with reports of up to 12 years, in mental health services.AimTo investigate whether data-driven pattern recognition methodologies applied to structural brain images can provide biomarkers to aid DID diagnosis...
December 7, 2018: British Journal of Psychiatry: the Journal of Mental Science
Andreas Menke
Mental disorders account for around one-third of disability worldwide and cause enormous personal and societal burden. Current pharmacotherapies and nonpharmacotherapies do help many patients, but there are still high rates of partial or no response, delayed effect, and unfavorable adverse effects. The current diagnostic taxonomy of mental disorders by the Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases relies on presenting signs and symptoms, but does not reflect evidence from neurobiological and behavioral systems...
2018: Pharmacogenomics and Personalized Medicine
Robert Howard, Elizabeth Cort, Rosie Bradley, Emma Harper, Linda Kelly, Peter Bentham, Craig Ritchie, Suzanne Reeves, Waleed Fawzi, Gill Livingston, Andrew Sommerlad, Sabu Oomman, Ejaz Nazir, Ramin Nilforooshan, Robert Barber, Chris Fox, Ajay Macharouthu, Pranathi Ramachandra, Vivek Pattan, John Sykes, Valerie Curran, Cornelius Katona, Tom Dening, Martin Knapp, Renee Romeo, Richard Gray
BACKGROUND: Very late-onset (aged ≥ 60 years) schizophrenia-like psychosis (VLOSLP) occurs frequently but no placebo-controlled, randomised trials have assessed the efficacy or risks of antipsychotic treatment. Most patients are not prescribed treatment. OBJECTIVES: The study investigated whether or not low-dose amisulpride is superior to placebo in reducing psychosis symptoms over 12 weeks and if any benefit is maintained by continuing treatment thereafter...
November 2018: Health Technology Assessment: HTA
Lanair Amaad Lett, Whitney U Orji, Ronnie Sebro
OBJECTIVE: To evaluate trends in racial, ethnic, and sex representation at US medical schools across 16 specialties: internal medicine, pediatrics, surgery, psychiatry, radiology, anesthesiology, obstetrics and gynecology, neurology, family practice, pathology, emergency medicine, orthopedic surgery, ophthalmology, otolaryngology, physical medicine and rehabilitation, and dermatology. Using a novel, Census-derived statistical measure of diversity, the S-score, we quantified the degree of underrepresentation for racial minority groups and female faculty by rank for assistant, associate, and full professors from 1990-2016...
2018: PloS One
Shi Yan, Eugene Kin Mun Wuan, Andrew Lai Huat Peh, Andre Teck Sng Tay, Sally Chih Wei Ho, Seyed Ehsan Saffari, David Choon Liang Teo
OBJECTIVES: The primary aim of this study was to evaluate the impact of an experience-based, longitudinal psychiatry training program in a Family Medicine residency on residents' attitudes toward depression and psychiatry. The secondary aim was to identify background predictor variables of changes in attitudes. METHODS: Pre- and post-training surveys were prospectively conducted on attitudes toward depression and psychiatry on Family Medicine residents undergoing an experience-based, longitudinal psychiatry training program...
November 15, 2018: Academic Psychiatry
Halit Necmi Uçar, Şafak Eray, Ömer Kocael, Lütfi Uçar, Müslüm Kaymak, Emanuele Lettieri, Ayşe Pinar Vural
BACKGROUND: Fascinating developments in big data technologies and unprecedented diffusion of social networking sites (SNSs) generate unseen opportunities for scientific fields, including psychiatry. This study focuses on the use of SNSs by adolescent psychiatric patients and the potential use of SNS-generated data to help medical practitioners diagnose and treat patients' mental health. Our objective is to understand and measure the psychiatric and individual conditions in which symptom-sharing occurs on SNSs and the frequency of these conditions...
December 2018: Psychiatria Danubina
Matthew E Hirschtritt, Gaddy Noy, Ellen Haller, Marshall Forstein
OBJECTIVE: Lesbian, gay, bisexual, transgender (LGBT) and other sexual minority individuals are at higher risk than non-LGBT individuals for multiple psychiatric conditions and suicide. However, little is known regarding LGBT-specific training among psychiatric residents. The authors sought to characterize LGBT-specific training among adult psychiatry residency programs. METHODS: An anonymous, cross-sectional survey was electronically distributed to U.S.-based adult psychiatry program directors between February and April 2018...
November 14, 2018: Academic Psychiatry
Rachael Horne, Jane A Foster
Advances in understanding the role of the microbiome in physical and mental health are at the forefront of medical research and hold potential to have a direct impact on precision medicine approaches. In the past 7 years, we have studied the role of microbiota-brain communication on behavior in mouse models using germ-free mice, mice exposed to antibiotics, and healthy specific pathogen free mice. Through our work and that of others, we have seen an amazing increase in our knowledge of how bacteria signal to the brain and the implications this has for psychiatry...
2018: Frontiers in Psychiatry
Ulrika Bejerholm, David Roe
BACKGROUND: One goal within positive psychiatry is to support the personal recovery of persons with mental illness and providing opportunities for well-being. AIM: The current article aims to introduce readers to the concept of personal recovery and the potential and importance of recovery-oriented services and measures. METHODS: A literature review was conducted to help consider the domains of 'personal recovery', 'recovery-oriented services/interventions', and 'measures'...
November 1, 2018: Nordic Journal of Psychiatry
Michael S Zastrozhin, Aleksandr S Sorokin, Tatyana V Agibalova, Elena A Grishina, Anastasiya Р Antonenko, Ilya N Rozochkin, Denis V Duzhev, Valentine Y Skryabin, Tatyana E Galaktionova, Ilya V Barna, Anna V Orlova, Albert D Aguzarov, Ludmila M Savchenko, Evgeny A Bryun, Dmitry A Sychev
INTRODUCTION: Although pharmacogenetic tests provide the information on a genotype and the predicted phenotype, these tests themselves do not provide the interpretation of data for a physician. There are currently approximately two dozen pharmacogenomic clinical decision support systems used in psychiatry. Implementation of clinical decision support systems capable of forming recommendations on drug and dose selection according to the results of pharmacogenetic testing is an urgent task...
October 25, 2018: Human Psychopharmacology
Chris Flood, Sally Barlow, Alan Simpson, Amanda Burls, Amy Price, Martin Cartwright, Stefano Brini
BACKGROUND: Utility scores are integral to health economics decision-making. Typically, utility scores have not been scored or developed with mental health service users. The aims of this study were to i) collaborate with service users to develop descriptions of five mental health states (psychosis, depression, eating disorder, medication side effects and self-harm); ii) explore feasibility and acceptability of using scenario-based health states in an e-survey; iii) evaluate which utility measures (standard gamble (SG), time trade off (TTO) and rating scale (RS)) are preferred; and iv) determine how different participant groups discriminate between the health scenarios and rank them...
2018: PloS One
Maarten A van Schijndel, Petra J Caarls, Jeroen D H van Wijngaarden, André I Wierdsma, Jeroen G Lijmer, Annette D Boenink, Witte J G Hoogendijk, Jeroen A van Waarde, Jan J V Busschbach
OBJECTIVE: To define generic quality indicators for general hospital psychiatry from the perspectives of patients, professionals (physicians, nurses, and managers), and payers (health insurance companies). METHODS: Quality variables were identified by reviewing the relevant literature. A working. group consisting of patients', professionals' and payers' representatives was mandated by their respective umbrella organizations. The working group prioritized the quality variables that were identified...
September 25, 2018: General Hospital Psychiatry
Chiaki Kawanishi, Takao Ishii, Naohiro Yonemoto, Mitsuhiko Yamada, Hirokazu Tachikawa, Toshifumi Kishimoto, Noa Tsujii, Satoshi Hashimoto, Toshihiko Kinoshita, Masaru Mimura, Yoshiro Okubo, Kotaro Otsuka, Reiji Yoshimura
INTRODUCTION: Suicide attempt is the most important risk factor for later suicide. A randomised-controlled, multicentre trial of postsuicide attempt case management for the prevention of further suicide attempts in Japan, named ACTION-J, has established effective interventions for prevention of suicide reattempts. The ACTION-J assertive case management intervention programme was adopted by the Japanese Ministry of Health, Labour and Welfare in 2016, when medical fees were revised. This nationwide programme is provided to patients who attempt suicide and who are admitted to emergency departments in Japan...
October 4, 2018: BMJ Open
Corina Aguilar-Raab, Marc N Jarczok, Marco Warth, Martin Stoffel, Friederike Winter, Maria Tieck, Judith Berg, Lobsang Tenzin Negi, Tim Harrison, Thaddeus W W Pace, Beate Ditzen
INTRODUCTION: Positive social interactions (PSIs) and stable relationships can exert substantial benefits on health. However, patients suffering from depression benefit less from these health-promoting effects. Moreover, relationship quality and even partners' health has been found to be negatively affected by depressive symptomatology, which may result in overall impairments in social functioning of a romantic couple. Psychobiological research indicates that these impairments may be accompanied by a maladaptive regulation of the patient's neuroendocrine response to external stressors...
October 4, 2018: BMJ Open
Lisa B Thorell, Hanna Chistiansen, Martin Hammar, Steve Berggren, Eric Zander, Sven Bölte
PURPOSE: The Conners Rating Scales are widely used in research and clinical practice for measuring attention deficit/hyperactivity disorder (ADHD) and associated problem behaviors, but country-specific norms are seldom collected. The current study presents the standardization of the Swedish Conners 3® Rating Scales. In addition, we compared the Swedish norms to those collected in the U.S. and Germany. MATERIAL AND METHODS: The study included altogether 3496 ratings of children and adolescents aged 6-18 years from population-based samples...
September 29, 2018: Nordic Journal of Psychiatry
Sabih Ahmad, Sadiq Hussain
OBJECTIVE: To find out the frequency of psychiatric morbidity in patients reporting to general medical camps in the Hindu Kush and Karakoram ranges of Pakistan. STUDY DESIGN: A cross-sectional study. PLACE AND DURATION OF STUDY: Four different valleys of the region, with the Psychiatry Department, Combined Military Hospital, Gilgit as the base, from August 2015 to December 2016. METHODOLOGY: Consenting adults of either gender, reporting to medical camps for various health related issues were administered Bradford Somatic Inventory 21 (BSI 21) and Self Report Questionnaire (SRQ)...
October 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Tsuyoshi Okamura, Chiaki Ura, Fumiko Miyamae, Mika Sugiyama, Hiroki Inagaki, Edahiro Ayako, Murayama Hiroshi, Keiko Motokawa, Shuichi Awata
AIM: Late-life depression is identified less often by general practitioners than depression in younger adults, but failure to have late-life depression recognized in a primary care setting can have fatal consequences. The aim of the present study was to examine the prevalence of depressed mood and loss of interest, and identify associated factors among community-dwelling older adults in a large-scale study. METHODS: A questionnaire was mailed to all residents (n = 132 005) aged ≥65 years in one Tokyo district...
September 20, 2018: Geriatrics & Gerontology International
A John Rush, Michael E Thase
Specific challenges that profoundly affect the outcome of treatment for depression include 1) patient engagement and retention in care and optimization of treatment adherence, 2) optimization of symptom and side effect control by medication adjustments using measurement-based care procedures, 3) restoration of daily functioning and quality of life, and 4) prevention or at least mitigation of symptomatic relapse or recurrence. According to data from the Sequenced Treatment Alternatives to Relieve Depression study, some 10%-15% of patients will not return for treatment after an initial thorough evaluation visit; an additional 20%-35% will not complete the first acute-phase treatment step, and another 20%-50% will not complete 6 months of continuation treatment...
September 17, 2018: American Journal of Psychiatry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"