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https://www.readbyqxmd.com/read/29676964/advanced-imaging-techniques-in-evaluation-of-colorectal-cancer
#1
Roberto García-Figueiras, Sandra Baleato-González, Anwar R Padhani, Antonio Luna-Alcalá, Ana Marhuenda, Joan C Vilanova, Iria Osorio-Vázquez, Anxo Martínez-de-Alegría, Antonio Gómez-Caamaño
Imaging techniques are clinical decision-making tools in the evaluation of patients with colorectal cancer (CRC). The aim of this article is to discuss the potential of recent advances in imaging for diagnosis, prognosis, therapy planning, and assessment of response to treatment of CRC. Recent developments and new clinical applications of conventional imaging techniques such as virtual colonoscopy, dual-energy spectral computed tomography, elastography, advanced computing techniques (including volumetric rendering techniques and machine learning), magnetic resonance (MR) imaging-based magnetization transfer, and new liver imaging techniques, which may offer additional clinical information in patients with CRC, are summarized...
April 20, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29670177/proton-decoupled-carbon-magnetic-resonance-spectroscopy-in-human-calf-muscles-at-7-t-using-a-multi-channel-radiofrequency-coil
#2
Sigrun Goluch, Roberta Frass-Kriegl, Martin Meyerspeer, Michael Pichler, Jürgen Sieg, Martin Gajdošík, Martin Krššák, Elmar Laistler
13 C magnetic resonance spectroscopy is a viable, non-invasive method to study cell metabolism in skeletal muscles. However, MR sensitivity of 13 C is inherently low, which can be overcome by applying a higher static magnetic field strength together with radiofrequency coil arrays instead of single loop coils or large volume coils, and 1 H decoupling, which leads to a simplified spectral pattern. 1 H-decoupled 13 C-MRS requires RF coils which support both, 1 H and 13 C, Larmor frequencies with sufficient electromagnetic isolation between the pathways of the two frequencies...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665708/cho-cr-ratio-at-mr-spectroscopy-as-a-biomarker-for-cellular-proliferation-activity-and-prognosis-in-glioma-correlation-with-the-expression-of-minichromosome-maintenance-protein-2
#3
Wenjing Gao, Xiao Wang, Fuyan Li, Wenqi Shi, Hongxia Li, Qingshi Zeng
Background Magnetic resonance (MR) spectroscopy (1 H-MRS) has been demonstrated to be useful in grading glioma, but the utility in assessing cellular proliferation activity and prognosis correlated with the expression of minichromosome maintenance protein 2 (MCM2) has not been reported. Purpose To explore the correlation between proton MR spectroscopy parameters (including choline [Cho]/creatine [Cr], N-acetyl aspartate [NAA]/Cr, and Cho/NAA ratios) and the expression of MCM2 and to further evaluate whether 1 H-MRS can predict cell proliferative activity and provide prognostic information in high-grade gliomas (HGGs)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29665193/validation-of-a-motion-robust-2d-sequential-technique-for-quantification-of-hepatic-proton-density-fat-fraction-during-free-breathing
#4
B Dustin Pooler, Diego Hernando, Jeannine A Ruby, Hiroshi Ishii, Ann Shimakawa, Scott B Reeder
BACKGROUND: Current chemical-shift-encoded (CSE) MRI techniques for measuring hepatic proton density fat fraction (PDFF) are sensitive to motion artifacts. PURPOSE: Initial validation of a motion-robust 2D-sequential CSE-MRI technique for quantification of hepatic PDFF. STUDY TYPE: Phantom study and prospective in vivo cohort. POPULATION: Fifty adult patients (27 women, 23 men, mean age 57.2 years). FIELD STRENGTH/SEQUENCE: 3D, 2D-interleaved, and 2D-sequential CSE-MRI acquisitions at 1...
April 17, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29663845/a-24-month-advanced-magnetic-resonance-imaging-study-of-multiple-sclerosis-patients-treated-with-alemtuzumab
#5
Irene M Vavasour, Roger Tam, David Kb Li, Cornelia Laule, Carolyn Taylor, Shannon H Kolind, Alex L MacKay, Adil Javed, Anthony Traboulsee
BACKGROUND: Tissue damage in both multiple sclerosis (MS) lesions and normal-appearing white matter (NAWM) are important contributors to disability and progression. Specific aspects of MS pathology can be measured using advanced imaging. Alemtuzumab is a humanised monoclonal antibody targeting CD52 developed for MS treatment. OBJECTIVE: To investigate changes over 2 years of advanced magnetic resonance (MR) metrics in lesions and NAWM of MS patients treated with alemtuzumab...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29659077/total-choline-quantification-measured-by-1h-mr-spectroscopy-as-early-predictor-of-response-after-neoadjuvant-treatment-for-locally-advanced-breast-cancer-the-impact-of-immunohistochemical-status
#6
Stylianos Drisis, Patrick Flamen, Michael Ignatiadis, Thierry Metens, Shih-Li Chao, Marie Chintinne, Marc Lemort
BACKGROUND: Validation of new biomarkers is essential for the early evaluation of neoadjuvant treatments. PURPOSE: To determine whether measurements of total choline (tCho) by 1H spectroscopy could predict morphological or pathological complete response (pCR) of neoadjuvant treatment and whether breast cancer subgroups are related to prediction accuracy. STUDY TYPE: Prospective, nonrandomized, monocentric, diagnostic study. POPULATION: Sixty patients were initially included with 39 women participating in the final cohort...
April 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29656982/erratum-to-whole-brain-neuronal-abnormalities-in-focal-epilepsy-quantified-with-proton-mr-spectroscopy-epilepsy-res-139-2018-85-91
#7
Ivan I Kirov, Ruben Kuzniecky, Hoby P Hetherington, Brian J Soher, Matthew S Davitz, James S Babb, Heath R Pardoe, Jullie W Pan, Oded Gonen
No abstract text is available yet for this article.
April 13, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29656881/fundamentals-of-functional-imaging-i-current-clinical-techniques
#8
A Luna, T Martín Noguerol, L Alcalá Mata
Imaging techniques can establish a structural, physiological, and molecular phenotype for cancer, which helps enable accurate diagnosis and personalized treatment. In recent years, various imaging techniques that make it possible to study the functional characteristics of tumors quantitatively and reproducibly have been introduced and have become established in routine clinical practice. Perfusion studies enable us to estimate the microcirculation as well as tumor angiogenesis and permeability using ultrafast dynamic acquisitions with ultrasound, computed tomography, or magnetic resonance (MR) imaging...
April 12, 2018: Radiología
https://www.readbyqxmd.com/read/29655566/development-of-mr-quantified-pancreatic-fat-deposition-as-a-cancer-risk-biomarker
#9
Peter O Coe, Steve R Williams, David M Morris, Ed Parkin, Michelle Harvie, Andrew G Renehan, Derek A O'Reilly
BACKGROUND: Excess body adiposity is associated with increased risk of pancreatic cancer, and in animal models excess intra-pancreatic fat is a driver of pancreatic carcinogenesis. Within a programme to evaluate pancreatic fat and PC risk in humans, we assessed whether MR-quantified pancreatic fat fraction (PFF) was 'fit for purpose' as an imaging biomarker. METHODS: We determined PFF using MR spectroscopy (MRS) and MR chemical shift imaging (CS-MR), in two groups...
April 3, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29649797/a-multimodal-approach-to-the-treatment-of-intraparenchymal-meningioma-in-a-7-year-old-boy-a-case-report
#10
Maria Caterina Vescovi, Daniele Bagatto, Gabriele Capo, Marta Maieron, Dario Marin, Enrico Pegolo, Barbara Tomasino
Intraparenchymal meningiomas are very rare: only 26 cases have been diagnosed in patients younger than 20 years since 1954. They can lead to preoperative differential diagnosis mistakes due to their atypical neuroimaging appearance. A multimodal approach is thus necessary to plan a surgical procedure aiming to receive the best extent of resection while preserving the patient's functional integrity. The authors report the case of a 7-year-old boy with a history of blurred vision, left eye deviation, and weakness on the left side of his body...
April 12, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29644834/31p-mr-spectroscopy-of-patients-with-mild-and-serious-lower-limb-ischemia
#11
Petr Sedivy, Miloslav Drobny, Monika Dezortova, Vit Herynek, Karel Roztocil, Helena Cermakova, Andrea Nemcova, Michal Dubsky, Milan Hajek
BACKGROUND: 31P MR spectroscopy is a technique for undertaking a comprehensive evaluation of muscle metabolism. The goal of this study was to compare patients with mild and severe lower limb ischemia measured by 31P MR spectroscopy at rest and during exercise. METHODS: 16 nondiabetic mild peripheral arterial occlusive disease (PAOD) patients, 23 diabetic PAOD patients with severe ischemia and 19 healthy controls were examined by rest and dynamic 31P MR spectroscopy with a 3T MR system equipped with an MR-compatible home-made pedal ergometer...
April 11, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29626940/pet-mri-in-infection-and-inflammation
#12
REVIEW
Martina Sollini, Raffaella Berchiolli, Margarita Kirienko, Alexia Rossi, A W J M Glaudemans, Riemer Slart, Paola Anna Erba
Hybrid positron emission tomography/magnetic resonance imaging (PET/MR) systems are now more and more available for clinical use. PET/MR combines the unique features of MR including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most of the evidence of the potential clinical utility of PET/MRI is available for neuroimaging. Other areas, where PET/MR can play a larger role include head and neck, upper abdominal, and pelvic tumours...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29619216/mutant-idh1-gliomas-downregulate-phosphocholine-and-phosphoethanolamine-synthesis-in-a-2-hydroxyglutarate-dependent-manner
#13
Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Hema Artee Luchman, J Gregory Cairncross, Russell O Pieper, Joanna J Phillips, Sabrina M Ronen
Background: Magnetic resonance spectroscopy (MRS) studies have identified elevated levels of the phospholipid precursor phosphocholine (PC) and phosphoethanolamine (PE) as metabolic hallmarks of cancer. Unusually, however, PC and PE levels are reduced in mutant isocitrate dehydrogenase 1 (IDHmut) gliomas that produce the oncometabolite 2-hydroxyglutarate (2-HG) relative to wild-type IDH1 (IDHwt) gliomas. The goal of this study was to determine the molecular mechanism underlying this unusual metabolic reprogramming in IDHmut gliomas...
2018: Cancer & Metabolism
https://www.readbyqxmd.com/read/29608677/regional-gaba-concentrations-modulate-inter-network-resting-state-functional-connectivity
#14
Xi Chen, Xiaoying Fan, Yuzheng Hu, Chun Zuo, Susan Whitfield-Gabrieli, Daphne Holt, Qiyong Gong, Yihong Yang, Diego A Pizzagalli, Fei Du, Dost Ongur
Coordinated activity within and differential activity between large-scale neuronal networks such as the default mode network (DMN) and the control network (CN) is a critical feature of brain organization. The CN usually exhibits activations in response to cognitive tasks while the DMN shows deactivations; in addition, activity between the two networks is anti-correlated at rest. To address this issue, we used functional MRI to measure whole-brain BOLD signal during resting-state and task-evoked conditions, and MR spectroscopy (MRS) to quantify GABA and glutamate concentrations, in nodes within the DMN and CN (MPFC and DLPFC, respectively) in 19 healthy individuals at 3 Tesla...
March 28, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29600890/preoperative-brain-temperature-imaging-on-proton-magnetic-resonance-spectroscopy-predicts-hemispheric-ischemia-during-carotid-endarterectomy-for-unilateral-carotid-stenosis-with-inadequate-collateral-blood-flow
#15
Shouta Tsutsui, Takamasa Nanba, Yoshichika Yoshioka, Makoto Sasaki, Shunrou Fujiwara, Masakazu Kobayashi, Kenji Yoshida, Kenya Miyoshi, Shinpei Sato, Kuniaki Ogasawara
Objective Preoperative magnetic resonance (MR) angiography sometimes shows the absence of collateral flow via the circle of Willis. This study examined whether brain temperature (BT) imaging on multi-voxel proton MR spectroscopy after this finding increases the accuracy of predicting hemispheric ischemia during internal carotid artery (ICA) clamping during endarterectomy for patients with symptomatic unilateral carotid stenosis. Methods In 52 patients with ICA stenosis (≥70%) and absence of collateral blood flow via the circle of Willis on preoperative MR angiography, BT imaging was displayed using proton multi-voxel MR spectroscopy...
March 30, 2018: Neurological Research
https://www.readbyqxmd.com/read/29593585/functional-magnetic-resonance-spectroscopy-the-new-mrs-for-cognitive-neuroscience-and-psychiatry-research
#16
REVIEW
Jeffrey A Stanley, Naftali Raz
Proton magnetic resonance spectroscopy (1 H MRS) is a well-established technique for quantifying the brain regional biochemistry in vivo . In most studies, however, the1 H MRS is acquired during rest with little to no constraint on behavior. Measured metabolite levels, therefore, reflect steady-state concentrations whose associations with behavior and cognition are unclear. With the recent advances in MR technology-higher-field MR systems, robust acquisition techniques and sophisticated quantification methods-1 H MRS is now experiencing a resurgence...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29588064/the-evaluation-of-the-effects-of-steroid-treatment-on-the-tumor-and-peritumoral-edema-by-dwi-and-mr-spectroscopy-in-brain-tumors
#17
Cahit Kural, Gokce Kaan Atac, Ozkan Tehli, Ilker Solmaz, Caglar Temiz, Irgen Hodaj, Yusuf Izci
OBJECTIVE: To investigate the effects of dexamethasone on brain tumor and peritumoral edema by different sequences of magnetic resonance imaging (MRI). MATERIALS AND METHODS: MRI was performed in 28 patients with brain tumor. Patients were divided into the 3 groups based on the histological diagnosis; Group I: high-grade glial tumor, Group II: low-grade glial tumor, and Group III: brain metastasis. The measurements of peritumoral edema volume and apparent diffusion coefficient (ADC) values were performed while the peak areas of cerebral metabolites were measured by spectroscopy in groups I and II...
March 13, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29587752/alzheimer-like-brain-metabolic-and-structural-features-in-cholesterol-fed-rabbit-detected-by-magnetic-resonance-imaging
#18
Ping Jin, Yongming Pan, Zhiyong Pan, Jianqin Xu, Min Lin, Zhichao Sun, Minli Chen, Maosheng Xu
BACKGROUND: Hypercholesterolemia is known to increase the risk of AD in later life, the purpose of this study is to illustrate brain metabolic and structural changes in a cholesterol-fed rabbit model of Alzheimer's Disease (AD) by using clinical 3 T Magnetic Resonance Imaging (MRI). METHODS: The Institutional Animal Care and Use Committee of Zhejiang Chinese Medical University approved the study. Totally 16 Japanese White Rabbits (JWR) were randomly divided into 2 groups including normal control group fed with routine diet (group NC) and high cholesterol diet group (group CD) fed a 2% cholesterol diet with 0...
March 27, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29587351/physicochemical-characterization-and-antioxidant-activity-of-humic-acids-isolated-from-peat-of-various-origins
#19
Maria V Zykova, Igor A Schepetkin, Michael V Belousov, Sergey V Krivoshchekov, Lyudmila A Logvinova, Kristina A Bratishko, Mekhman S Yusubov, Sergey V Romanenko, Mark T Quinn
Although humic acids (HAs) from peat exhibit various therapeutic properties, there is little information available concerning their physicochemical and antioxidant properties. To address this issue, nine different types of peat, including oligotrophic, mesotrophic, and minerotrophic peat samples, were used for isolation of HA fractions by basic (HAb) and pyrophosphate (HAp) extractions. Physical parameters of the HAs were analyzed by UV-Vis, fluorescent, infrared (IR), and electron paramagnetic resonance (EPR) spectroscopy...
March 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29572626/is-visual-activation-associated-with-changes-in-cerebral-high-energy-phosphate-levels
#20
Bart L van de Bank, Marnix C Maas, Lauren J Bains, Arend Heerschap, Tom W J Scheenen
Phosphorus magnetic resonance spectroscopy (31 P MRS) has been employed before to assess phosphocreatine (PCr) and other high-energy phosphates in the visual cortex during visual stimulation with inconsistent results. We performed functional31 P MRS imaging in the visual cortex and control regions during a visual stimulation paradigm at an unprecedented sensitivity, exploiting a dedicated RF coil design at a 7 T MR system. Visual stimulation in a 3 min 24 s on-off paradigm in eight young healthy adults generated a clear BOLD effect with traditional1 H functional MRI in the visual cortex (average z score 9...
March 23, 2018: Brain Structure & Function
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