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MR spectroscopy

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https://www.readbyqxmd.com/read/29232030/reproducibility-of-relaxometry-of-human-lumbar-vertebrae-at-3-tesla-using-1-h-mr-spectroscopy
#1
Bernhard Neumayer, Thomas Widek, Rudolf Stollberger, Eva Scheurer
BACKGROUND: MR spectroscopy is widely used for fat fraction quantification of human lumbar vertebrae. However, the measurements need to be corrected for relaxation effects. PURPOSE: The aim of this study was to determine the reproducibility of relaxometry in human lumbar vertebrae required for the correction of fat fraction measurements using magnetic resonance spectroscopy at 3 Tesla. Such information provides error estimates and guidance regarding reliability for future studies...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29230178/human-cardiac-31p-mr-spectroscopy-at-3-tesla-cannot-detect-failing-myocardial-energy-homeostasis-during-exercise
#2
Adrianus J Bakermans, Jason N Bazil, Aart J Nederveen, Gustav J Strijkers, S Matthijs Boekholdt, Daniel A Beard, Jeroen A L Jeneson
Phosphorus-31 magnetic resonance spectroscopy (31P-MRS) is a unique non-invasive imaging modality for probing in vivo high-energy phosphate metabolism in the human heart. We investigated whether current 31P-MRS methodology would allow for clinical applications to detect exercise-induced changes in (patho-)physiological myocardial energy metabolism. Hereto, measurement variability and repeatability of three commonly used localized 31P-MRS methods [3D image-selected in vivo spectroscopy (ISIS) and 1D ISIS with 1D chemical shift imaging (CSI) oriented either perpendicular or parallel to the surface coil] to quantify the myocardial phosphocreatine (PCr) to adenosine triphosphate (ATP) ratio in healthy humans (n = 8) at rest were determined on a clinical 3 Tesla MR system...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29227152/analysis-of-intra-and-extra-myocellular-lipids-in-the-multifidus-muscle-in-patients-with-chronic-low-back-pain-using-mr-spectroscopy
#3
Hiroyuki Takashima, Tsuneo Takebayashi, Izaya Ogon, Mitsunori Yoshimoto, Tomonori Morita, Rui Imamura, Mitsuhiro Nakanishi, Hiroshi Nagahama, Yoshinori Terashima, Toshihiko Yamashita
OBJECTIVE: To analyze the intra (IMCL) and extra-myocellular lipids (EMCL) concentration in the multifidus muscle (Mm) using MR spectroscopy (MRS) in patients with low back pain (LBP), and to evaluate the correlation between those lipid concentrations and age, obesity, atrophy of the Mm and LBP intensity. METHODS: Sixty LBP patients underwent routine diagnostic MRI of the lumbar spine before undergoing imaging for the study. Body mass index (BMI), as an indicator of obesity and visual analogue score (VAS), as an indicator of LBP were also measured...
December 11, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29221153/-68ga-pentixafor-for-cxcr4-imaging-in-a-pc-3-prostate-cancer-xenograft-model-comparison-with-18f-fdg-pet-ct-mri-and-ex-vivo-receptor-expression
#4
Sarah M Schwarzenböck, Jan Stenzel, Thomas Otto, Heike V Helldorff, Carina Bergner, Jens Kurth, Stefan Polei, Tobias Lindner, Romina Rauer, Alexander Hohn, Oliver W Hakenberg, Hans J Wester, Brigitte Vollmar, Bernd J Krause
Purpose: The aim was to characterize the properties of [68Ga]Pentixafor as tracer for prostate cancer imaging in a PC-3 prostate cancer xenograft mouse model and to investigate its correlation with [18F]FDG PET/CT, magnetic resonance imaging (MRI) and ex vivo analyses. Methods: Static [68Ga]Pentixafor and [18F]FDG PET as well as morphological/ diffusion weighted MRI and 1H MR spectroscopy was performed. Imaging data were correlated with ex vivo biodistribution and CXCR4 expression in PC-3 tumors (immunohistochemistry (IHC), mRNA analysis)...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218626/treatment-related-changes-in-glioblastoma-a-review-on-the-controversies-in-response-assessment-criteria-and-the-concepts-of-true-progression-pseudoprogression-pseudoresponse-and-radionecrosis
#5
REVIEW
P D Delgado-López, E Riñones-Mena, E M Corrales-García
The assessment of response to therapy in glioblastoma remains a challenge, because the surrogate measures of survival are subject to radiographic misinterpretation. A solid and reliable definition of progression is needed for both clinical decision-making and for evaluating response within the clinical trials. Historically, assessment criteria have used radiologic and clinical features aimed to correctly classify patients into progressive or non-progressive disease. The widely used RANO criteria are a valuable tool in disease evaluation, both in the clinical setting and in the clinical trials...
December 7, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29217493/effects-of-proximity-and-noise-level-of-phased-array-coil-elements-on-overall-signal-to-noise-in-parallel-mr-spectroscopy
#6
Candace C Fleischer, Xiaodong Zhong, Hui Mao
Parallel imaging using phased array coils facilitates accelerated magnetic resonance imaging (MRI) and spectroscopy (MRS). Parallel data reconstruction requires the combination of data from individual coil elements, but limited combination algorithms currently exist for higher-order phased arrays and MRS data. Here, we present a systematic framework for identifying coil proximity-related signal inhomogeneities and noise levels in phased array coils that may affect sensitivity of parallel MRS. Single-voxel MRS was acquired in nine voxel positions in a brain spectroscopy phantom on a 3T whole-body MR scanner using commercially available 64-, 32-, and 20-channel phased array coils...
December 4, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29212047/whole-brain-neuronal-abnormalities-in-focal-quantified-with-proton-mr-spectroscopy
#7
Ivan I Kirov, Ruben Kuzniecky, Hoby P Hetherington, Brian J Soher, Matthew S Davitz, James S Babb, Heath R Pardoe, Jullie W Pan, Oded Gonen
OBJECTIVE: To test the hypothesis that localization-related epilepsy is associated with widespread neuronal dysfunction beyond the ictal focus, reflected by a decrease in patients' global concentration of their proton MR spectroscopy (1H-MRS) observed marker, N-acetyl-aspartate (NAA). METHODS: Thirteen patients with localization-related epilepsy (7 men, 6 women) 40±13 (mean±standard-deviation)years old, 8.3±13.4years of disease duration; and 14 matched controls, were scanned at 3 T with MRI and whole-brain (WB) 1H MRS...
December 2, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29208345/multi-class-parkinsonian-disorders-classification-with-quantitative-mr-markers-and-graph-based-features-using-support-vector-machines
#8
Rita Morisi, David Neil Manners, Giorgio Gnecco, Nico Lanconelli, Claudia Testa, Stefania Evangelisti, Lia Talozzi, Laura Ludovica Gramegna, Claudio Bianchini, Giovanna Calandra-Buonaura, Luisa Sambati, Giulia Giannini, Pietro Cortelli, Caterina Tonon, Raffaele Lodi
BACKGROUND AND PURPOSE: In this study we attempt to automatically classify individual patients with different parkinsonian disorders, making use of pattern recognition techniques to distinguish among several forms of parkinsonisms (multi-class classification), based on a set of binary classifiers that discriminate each disorder from all others. METHODS: We combine diffusion tensor imaging, proton spectroscopy and morphometric-volumetric data to obtain MR quantitative markers, which are provided to support vector machines with the aim of recognizing the different parkinsonian disorders...
November 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29203776/non-water-suppressed-1h-mr-spectroscopy-with-orientational-prior-knowledge-shows-potential-for-separating-intra-and-extramyocellular-lipid-signals-in-human-myocardium
#9
Ariane Fillmer, Andreas Hock, Donnie Cameron, Anke Henning
Conditions such as type II diabetes are linked with elevated lipid levels in the heart, and significantly increased risk of heart failure; however, metabolic processes underlying the development of cardiac disease in type II diabetes are not fully understood. Here we present a non-invasive method for in vivo investigation of cardiac lipid metabolism: namely, IVS-McPRESS. This technique uses metabolite-cycled, non-water suppressed 1H cardiac magnetic resonance spectroscopy with prospective and retrospective motion correction...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203059/increased-glutamate%C3%A2-glutamine-levels-in-the-thalamus-of-patients-with-essential-tremor-a-preliminary-proton-mr-spectroscopic-study
#10
Gaetano Barbagallo, Gennarina Arabia, Fabiana Novellino, Rita Nisticò, Maria Salsone, Maurizio Morelli, Federico Rocca, Andrea Quattrone, Manuela Caracciolo, Umberto Sabatini, Andrea Cherubini, Aldo Quattrone
INTRODUCTION: The aim of this study was to investigate the thalamic biochemical profile in patients with essential tremor (ET), using proton magnetic resonance spectroscopy (1H-MRS), and to explore the correlations between clinical and biochemical data. METHODS: Sixteen patients with ET and 14 healthy controls participated in this study. After conventional MR imaging, single-voxel 1H-MRS (TR = 2000 ms; TE = 28 ms) was performed by using a PROBE-SV system implemented on a 3-T scanner...
November 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29196269/diffusion-mri-and-mr-spectroscopy-reveal-microstructural-and-metabolic-brain-alterations-in-chronic-mild-stress-exposed-rats-a-cms-recovery-study
#11
Ahmad Raza Khan, Brian Hansen, Ove Wiborg, Christopher D Kroenke, Sune Nørhøj Jespersen
Chronic mild stress (CMS) induced depression elicits several debilitating symptoms and causes a significant economic burden on society. High variability in the symptomatology of depression poses substantial impediment to accurate diagnosis and therapy outcome. CMS exposure induces significant metabolic and microstructural alterations in the hippocampus (HP), prefrontal cortex (PFC), caudate-putamen (CP) and amygdala (AM), however, recovery from these maladaptive changes are limited and this may provide negative effects on the therapeutic treatment and management of depression...
November 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/29183816/evaluation-of-diffusion-weighted-imaging-in-the-context-of-multi-parametric-mri-of-the-prostate-in-the-assessment-of-suspected-low-volume-prostatic-carcinoma
#12
Ioannis Papadopoulos, Jonathan Phillips, Rhodri Evans, Neil Fenn, Sophie Shermer
Data from a multi-parameteric MRI study of patients with possible early-stage prostate cancer was assessed with a view to creating an efficient clinical protocol. Based on a correlation analysis suggesting that diffusion-weighted imaging (DWI) scores are more strongly correlated with overall PIRADS scores than other modalities such as dynamic contrast enhanced imaging or spectroscopy, we investigate the combination of T2-weighted imaging (T2w) and DWI as a potential diagnostic tool for prostate cancer detection, staging and guided biopsies...
November 25, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29178414/developing-and-validating-a-multivariable-prediction-model-to-improve-the-diagnostic-accuracy-in-determination-of-cervical-versus-endometrial-origin-of-uterine-adenocarcinomas-a-prospective-mr-study-combining-diffusion-weighted-imaging-and-spectroscopy
#13
Gigin Lin, Yu-Chun Lin, Ren-Chin Wu, Lan-Yan Yang, Hsin-Ying Lu, Shang-Yueh Tsai, Yu-Ting Huang, Yen-Ling Huang, Kuan-Ying Lu, Koon-Kwan Ng, Tzu-Chen Yen, Angel Chao, Chyong-Huey Lai, Ji-Hong Hong
BACKGROUND: A triage test to assist clinical decision-making on choosing primary chemoradiation for cervical carcinomas or primary surgery for endometrial carcinomas is important. PURPOSE OR HYPOTHESIS: To develop and validate a multiparametric prediction model based on MR imaging and spectroscopy in distinguishing adenocarcinomas of uterine cervical or endometrial origin. STUDY TYPE: Prospective diagnostic accuracy study. POPULATION: Eighty-seven women: 25 cervical and 62 endometrial adenocarcinomas divided into training (n = 43; cervical/endometrial adenocarcinomas = 11/32) and validation (n = 44; 14/30) datasets...
November 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29157849/imaging-of-chronic-concussion
#14
REVIEW
Eliana Bonfante, Roy Riascos, Octavio Arevalo
Conventional imaging findings in patients with cerebral concussion and chronic traumatic encephalopathy are absent or subtle in the majority of cases. The most common abnormalities include cerebral volume loss, enlargement of the cavum of the septum pellucidum, cerebral microhemorrhages, and white matter signal abnormalities, all of which have poor sensitivity and specificity. Advanced imaging modalities, such as diffusion tensor imaging (DTI), blood oxygen level dependent functional MR Imaging (BOLD fMRI), MR spectroscopy, perfusion imaging, positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetoencephalography detect physiologic abnormalities in symptomatic patients and, although currently in the investigation phase, may become useful in the clinical arena...
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29156000/structural-rearrangements-in-mrna-upon-its-binding-to-human-80s-ribosomes-revealed-by-epr-spectroscopy
#15
Alexey A Malygin, Dmitri M Graifer, Maria I Meschaninova, Alya G Venyaminova, Ivan O Timofeev, Andrey A Kuzhelev, Olesya A Krumkacheva, Matvey V Fedin, Galina G Karpova, Elena G Bagryanskaya
The model mRNA (MR), 11-mer RNA containing two nitroxide spin labels at the 5'- and 3'-terminal nucleotides and prone to form a stable homodimer (MR)2, was used for Electron Paramagnetic Resonance study of structural rearrangements in mRNA occurring upon its binding to human 80S ribosomes. The formation of two different types of ribosomal complexes with MR was observed. First, there were stable complexes where MR was fixed in the ribosomal mRNA-binding channel by the codon-anticodon interaction(s) with cognate tRNA(s)...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29155183/insights-into-brain-microstructure-from-in-vivo-dw-mrs
#16
Marco Palombo, Noam Shemesh, Itamar Ronen, Julien Valette
Many developmental processes, such as plasticity and aging, or pathological processes such as neurological diseases are characterized by modulations of specific cellular types and their microstructures. Diffusion-weighted Magnetic Resonance Imaging (DW-MRI) is a powerful technique for probing microstructure, yet its information arises from the ubiquitous, non-specific water signal. By contrast, diffusion-weighted Magnetic Resonance Spectroscopy (DW-MRS) allows specific characterizations of tissues such as brain and muscle in vivo by quantifying the diffusion properties of MR-observable metabolites...
November 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/29148698/chelator-free-conjugation-of-99mtc-and-gd3-to-pegylated-nanographene-oxide-for-dual-modality-spect-mr-imaging-of-lymph-nodes
#17
Tianye Cao, Xiaobao Zhou, Yingying Zheng, Yuyun Sun, Jian Zhang, Wei Chen, Jianping Zhang, Zhiguo Zhou, Shi-Ping Yang, Yingjian Zhang, Hong Yang, Ming-Wei Wang
PEGylated ultra-small nanographene oxide (usNGO-PEG) has exhibited great potential in nanotheranostics due to its newly-discovered physicochemical properties derived from the rich functional groups and  bonds. Herein, we developed a general, simple and kit-like preparation approach for 99mTcI- and Gd-anchored NGO-PEG using a chelator-free strategy. In this strategy, [99mTcI(CO)3(OH2)3]+ (abbreviated to 99mTcI) and GdCl3 were mixed with usNGO-PEG to yield 99mTc- and Gd-usNGO-PEG via the synergistic coordination of N and O atoms from NGO and PEG with 99mTcI and Gd3+ without additional exogenous chelators...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148253/quantification-of-vascular-damage-in-acute-kidney-injury-with-fluorine-magnetic-resonance-imaging-and-spectroscopy
#18
Jeremy K Moore, Junjie Chen, Hua Pan, Joseph P Gaut, Sanjay Jain, Samuel A Wickline
PURPOSE: To design a fluorine MRI/MR spectroscopy approach to quantify renal vascular damage after ischemia-reperfusion injury, and the therapeutic response to antithrombin nanoparticles (NPs) to protect kidney function. METHODS: A total of 53 rats underwent 45 min of bilateral renal artery occlusion and were treated at reperfusion with either plain perfluorocarbon NPs or NPs functionalized with a direct thrombin inhibitor (PPACK:phenyalanine-proline-arginine-chloromethylketone)...
November 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29146979/thickness-dependent-parasitic-channel-formation-at-aln-si-interfaces
#19
Hareesh Chandrasekar, K N Bhat, Muralidharan Rangarajan, Srinivasan Raghavan, Navakanta Bhat
The performance of GaN-on-Silicon electronic devices is severely degraded by the presence of a parasitic conduction pathway at the nitride-substrate interface which contributes to switching losses and lower breakdown voltages. The physical nature of such a parasitic channel and its properties are however, not well understood. We report on a pronounced thickness dependence of the parasitic channel formation at AlN/Si interfaces due to increased surface acceptor densities at the interface in silicon. The origin of these surface acceptors is analyzed using secondary ion mass spectroscopy measurements and traced to thermal acceptor formation due to Si-O-N complexes...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29143277/myo-inositol-concentration-in-mr-spectroscopy-for-differentiating-high-grade-glioma-from-primary-central-nervous-system-lymphoma
#20
Hiroaki Nagashima, Takashi Sasayama, Kazuhiro Tanaka, Katsusuke Kyotani, Naoko Sato, Masahiro Maeyama, Masaaki Kohta, Junichi Sakata, Yusuke Yamamoto, Kohkichi Hosoda, Tomoo Itoh, Ryohei Sasaki, Eiji Kohmura
It is sometimes difficult to distinguish gliomas from other tumors on routine imaging. In this study, we assessed whether 3-T magnetic resonance spectroscopy (MRS) with LCModel software might be useful for discriminating glioma from other brain tumors, such as primary central nervous system lymphomas (PCNSLs) and metastatic tumors. A total of 104 cases of brain tumor (66 gliomas, 20 PCNSLs, 6 metastatic tumors, 12 other tumors) were preoperatively investigated with short echo time (35 ms) single-voxel 3-T MRS...
November 15, 2017: Journal of Neuro-oncology
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