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MR spectroscopy

Ju-Hwi Kim, Woo-Youl Jang, Tae-Young Jung, Kyung-Sub Moon, Shin Jung, Kyung-Hwa Lee, In-Young Kim
In this study, we report a case of solitary Langerhans cell histiocytosis (LCH) without skull or systemic lesions, including reviewing the initial magnetic resonance (MR) findings of cerebral LCH. A 36-year-old male patient presented with generalized tonic-clonic type seizure. Brain MR imaging showed a 3cm mass lesion involving the right frontal lobe. It showed iso-intensity on T1-weighted images and hyperintensity on T2-weighted images. After gadolinium enhancement, the mass showed heterogeneous enhancement with perilesional edema and additional adjacent leptomeningeal enhancement...
June 18, 2018: World Neurosurgery
Gregory Simchick, Amelia Yin, Hang Yin, Qun Zhao
PURPOSE: To explore, at a high field strength of 7T, the performance of various fat spectral models on the quantification of triglyceride composition and proton density fat fraction (PDFF) using chemical-shift encoded MRI (CSE-MRI). METHODS: MR data was acquired from CSE-MRI experiments for various fatty materials, including oil and butter samples and in vivo brown and white adipose mouse tissues. Triglyceride composition and PDFF were estimated using various a priori 6- or 9-peak fat spectral models...
June 18, 2018: Magnetic Resonance Imaging
Xiaodi Li, Yuzhou Wang, Zhanhang Wang, Jianjun Lu, Yan Xu, Jinlong Ye, Zuying Kuang, Bo Li, Mengqiu Pan, Wenming Chen, Shuisheng Lu, Ziyang Zhou, Lina Cheng, Honghao Wang
To compare the utility and limitation of magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS), a retrospective review of 17 MELAS and 26 AIS patients were performed. In all patients both MRS and ASL scans were performed within 1 week after admission. Demographic, clinical, laboratory and MR imaging data were reviewed and compared between the two groups...
June 16, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Eric A Woodcock, Muzamil Arshad, Dalal Khatib, Jeffrey A Stanley
Background: Single-voxel proton magnetic resonance spectroscopy (1 H MRS) is a powerful technique for studying in vivo neurochemistry, but has an often-overlooked source of error variance: inconsistent voxel placement between scans. We developed and evaluated an Automated Voxel Placement (AVP) procedure for accurate and reliable 1 H MRS voxel prescription. AVP is a suite of Linux-based programs that facilitate automated template-driven single-voxel coregistration. Methods: Three studies were conducted to evaluate AVP for prescription of one voxel: left dorsolateral prefrontal cortex...
2018: Journal of Neuroimaging in Psychiatry & Neurology
Elizabeth Joe, Luis D Medina, John M Ringman, Joseph O'Neill
1 H magnetic resonance spectroscopy (MRS) can reveal changes in brain biochemistry in vivo in humans and has been applied to late onset Alzheimer disease (AD). Carriers of mutations for autosomal dominant Alzheimer disease (ADAD) may show changes in levels of metabolites prior to the onset of clinical symptoms. Proton MR spectra were acquired at 1.5 T for 16 cognitively asymptomatic or mildly symptomatic mutation carriers (CDR < 1) and 11 non-carriers as part of a comprehensive cross-sectional study of preclinical ADAD...
June 16, 2018: Brain Imaging and Behavior
Alice Egerton, Anouk Marsman, Brian V Broberg, Hilleke E Hulshoff Pol
No abstract text is available yet for this article.
2018: Frontiers in Psychiatry
Anselmo Rodriguez, Caroline Rocha, Rodolfo Piazza, Caio Santos, Marco Morales, Fernando Faria, Zubair Iqbal, Lucas Barbosa, Yuri Chaves, Luis Mariuba, Miguel Jafelicci, Rodrigo Marques
Magnetic nanoparticles (nps) have attracted great attention owing of their applications in biomedical field. In present work, maghemite nps (γFe2O3) were prepared by sonochemical method and further functionalized with APTS via silanization reaction. Subsequently, amino group in APTS-Fe2O3 beads were converted to carboxylic acid (CARB-Fe2O3) through succinic anhydride reaction, as confirmed by Fourier transform infrared spectroscopy and Zeta potential measurements. The beads have spherical shape with diameter of 7 nm as determined by X-ray powder diffraction and transmission electron microscopy...
June 12, 2018: Nanotechnology
Nuno Pedrosa de Barros, Raphael Meier, Martin Pletscher, Samuel Stettler, Urspeter Knecht, Evelyn Herrmann, Philippe Schucht, Mauricio Reyes, Jan Gralla, Roland Wiest, Johannes Slotboom
PURPOSE: To improve the detection of peritumoral changes in GBM patients by exploring the relation between MRSI information and the distance to the solid tumor volume (STV) defined using structural MRI (sMRI). METHODS: Twenty-three MRSI studies (PRESS, TE 135 ms) acquired from different patients with untreated GBM were used in this study. For each MRSI examination, the STV was identified by segmenting the corresponding sMRI images using BraTumIA, an automatic segmentation method...
June 12, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Jun Shibasaki, Noriko Aida, Naho Morisaki, Moyoko Tomiyasu, Yuri Nishi, Katsuaki Toyoshima
Purpose To investigate the time-course changes and predictive utility of brain metabolite concentrations in neonatal hypoxic-ischemic encephalopathy (HIE). Materials and Methods Sixty-eight neonates (age, 35-41 gestational weeks) with HIE were admitted to a neonatal intensive care unit between September 2009 and March 2016 and examined by using proton MR spectroscopy at 18-96 hours (n = 25) and 7-14 days (n = 64) after birth (35-43 postmenstrual weeks) to estimate metabolite concentrations in the deep gray matter...
June 12, 2018: Radiology
Julie Abildgaard, Else Rubaek Danielsen, Emma Dorph, Carsten Thomsen, Anders Juul, Caroline Ewertsen, Bente Klarlund Pedersen, Anette Tønnes Pedersen, Thorkil Ploug, Birgitte Lindegaard
Context: Menopause is associated with an increased incidence of insulin resistance and diabetes. Objective: The aim of this study was to explore the lipid deposition in liver and skeletal muscle and investigate the association with insulin sensitivity in post- and premenopausal women. Design, setting, participants and measurements: Single-centre cross-sectional study of 55 healthy women between 45- and 60 years of age. We measured lipid deposition in the liver with MR spectroscopy, intramuscular- and intraabdominal lipid deposition with MRI, body composition with a DEXA-scan and insulin sensitivity with the composite Matsuda Index...
June 7, 2018: Journal of Clinical Endocrinology and Metabolism
Xin Fu, Lulu Yu, Yanshu Li, Yu Zhang, Xiaoping Xiao, Jinsheng Zhang, Ting Shu, Cai Jing, Qun Tang
Magnetic nanoparticles are emerging as promising candidates for next-generation of imaging contrast agents and its performance was largely dependent on physico-chemistry properties. In this paper, A new type of "top down" fabrication technique was developed to synthesize ultrasmall magnetic nanoparticle as contrast enhancer. In detailed, home-made oxygen plasma generator fragments larger KMnF3 nanoparticle (22 nm) into smaller (&lt;5 nm) particle with enhanced hydrophilicity, as massive activated oxygen species produced during plasma could severally etch the nanoparticle, and VUV light irradiated it heavily as well, leaving it weak crystallinity, even splitting into ultrafine particle, also its surface transformed from hydrophobic to hydrophilic by oxidizing the passivated ligand, evidenced from the spectroscopy and microscopy...
June 11, 2018: Nanotechnology
Marianne K Poulsen, Birgitte Nellemann, Bo Martin Bibby, Hans Stødkilde-Jørgensen, Steen B Pedersen, Henning Grønbaek, Søren Nielsen
The present study assess long-term effects of high-dose Resveratrol (RSV) on basal and insulin-mediated very low-desity lipoprotein triglyceride (VLDL-TG), palmitate and glucose kinetics, and liver fat content in men with nonalcoholic fatty liver disease (NAFLD). Participants (n=16) were non-diabetic, upper-body obese (BMI >28 kg/m2 , WHR >0.9) men with NAFLD randomized (1:1) in a double-blinded, placebo-controlled clinical trial to either RSV or placebo (500 mg 3 times daily) for 6 months. Magnetic resonance (MR) spectroscopy, dual-X-ray absorptiometry and MR imaging assessed liver fat content and body composition, respectively...
June 8, 2018: Diabetes, Obesity & Metabolism
Anne Rijpma, Marinette van der Graaf, Olga Meulenbroek, Marcel G M Olde Rikkert, Arend Heerschap
In Alzheimer's disease (AD), defects in essential metabolic processes for energy supply and phospholipid membrane function have been implicated in the pathological process. However, post-mortem investigations are generally limited to late stage disease and prone to tissue decay artifacts. In vivo assessments of high energy phosphates, tissue pH and phospholipid metabolites are possible by phosphorus MR spectroscopy (31 P-MRS), but so far only small studies, mostly focusing on single brain regions, have been performed...
2018: NeuroImage: Clinical
Tai-Wei Wu, Benita Tamrazi, Kai-Hsiang Hsu, Eugenia Ho, Aaron J Reitman, Matthew Borzage, Stefan Blüml, Jessica L Wisnowski
Background: Cerebral lactate concentration can remain detectable in neonatal hypoxic-ischemic encephalopathy (HIE) after hemodynamic stability. The temporal resolution of regional cerebral lactate concentration in relation to the severity or area of injury is unclear. Furthermore, the interplay between serum and cerebral lactate in neonatal HIE has not been well defined. The study aims to describe cerebral lactate concentration in neonatal HIE in relation to time, injury, and serum lactate...
2018: Frontiers in Neurology
Monika Cichocka, Anna Bereś
INTRODUCTION: The knowledge of metabolic changes across the lifespan is poorly understood. Thus we systematically reviewed the available literature to determine the changes in brain biochemical composition from fetus to older age and tried to explain them in the context of neural, cognitive, and behavioral changes. METHODS: The search identified 1262 articles regarding proton magnetic resonance spectroscopy (1H MRS) examinations through December 2017. The following data was extracted: age range of the subjects, number of subjects studied, brain regions studied, MRS sequence used, echo time, MR system, method of statistical analysis, metabolites analyzed, significant differences in metabolites concentrations with age as well as the way of presentation of the results...
June 1, 2018: Ageing Research Reviews
M I Vargas, B M A Delattre, J Boto, J Gariani, A Dhouib, A Fitsiori, J L Dietemann
In this article, we illustrate the main advanced magnetic resonance imaging (MRI) techniques used for imaging of the spine and spinal cord in children and adults. This work focuses on daily clinical practice and aims to address the most common questions and needs of radiologists. We will also provide tips to solve common problems with which we were confronted. The main clinical indications for each MR technique, possible pitfalls and the challenges faced in spine imaging because of anatomical and physical constraints will be discussed...
June 1, 2018: Insights Into Imaging
René M Botnar, Julia Brangsch, Carolin Reimann, Christian H P Janssen, Reza Razavi, Bernd Hamm, Marcus R Makowski
BACKGROUND: The incidence of abdominal aortic aneurysms (AAAs) will significantly increase during the next decade. Novel biomarkers, besides diameter, are needed for a better characterization of aneurysms and the estimation of the risk of rupture. Fibrin is a key protein in the formation of focal hematoma associated with the dissection of the aortic wall and the development of larger thrombi during the progression of AAAs. This study evaluated the potential of a fibrin-specific magnetic resonance (MR) probe for the in vivo characterization of the different stages of AAAs...
May 30, 2018: Journal of the American Heart Association
Danielle N Lyons, Hemendra Vekaria, Teresa Macheda, Vikas Bakshi, David K Powell, Brian T Gold, Ai-Ling Lin, Pat Sulllivan, Adam D Bachstetter
Metabolic uncoupling has been well-characterized during the first minutes-to-days after a traumatic brain injury (TBI), yet mitochondrial bioenergetics during the weeks-to-months after a brain injury is poorly defined, particularly after a mild TBI. We hypothesized that a closed head injury (CHI) would be associated with deficits in mitochondrial bioenergetics at one month after the injury. A significant decrease in state-III (ATP production) and state-V (complex-I) driven mitochondrial respiration was found at 1-month post-injury in adult C57Bl/6J mice...
May 29, 2018: Journal of Neurotrauma
Sumra Bari, Diana O Svaldi, Ikbeom Jang, Trey E Shenk, Victoria N Poole, Taylor Lee, Ulrike Dydak, Joseph V Rispoli, Eric A Nauman, Thomas M Talavage
Long term neurological impairments due to repetitive head trauma are a growing concern for collision sport athletes. American Football has the highest rate of reported concussions among male high school athletes, a position held by soccer for female high school athletes. Recent research has shown that subconcussive events experienced by collision sport athletes can be a further significant source of accrued damage. Collision sport athletes experience hundreds of subconcussive events in a single season, and these largely go uninvestigated as they produce no overt clinical symptoms...
May 25, 2018: Brain Imaging and Behavior
Nanako Takase, Noboru Igarashi, Hiromichi Taneichi, Kumi Yasukawa, Takafumi Honda, Hiromichi Hamada, Jun-Ichi Takanashi
Reduced diffusion in the subcortical white matter has been reported in some infants with traumatic brain injury (TBI), including abusive head trauma. However, the pathomechanisms of the lesions and clinical features are uncertain. We herein report two infants with TBI who presented with biphasic clinical courses and late reduced diffusion in the subcortical white matter, and reviewed seven clinically and radiologically similar patients with TBI. Their clinical features (secondary neurological symptoms on days 3 to 6) and radiological findings (normal diffusion on days 1 to 2, followed by reduced diffusion on days 3 to 6) are very similar to those observed in patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD)...
July 15, 2018: Journal of the Neurological Sciences
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