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https://www.readbyqxmd.com/read/28638107/tracking-protein-function-with-sodium-multi-quantum%C3%A2-spectroscopy-in-a-3d-tissue-culture-based-on-microcavity-arrays
#1
Andreas Neubauer, Cordula Nies, Victor D Schepkin, Ruomin Hu, Matthias Malzacher, Jorge Chacón-Caldera, David Thiele, Eric Gottwald, Lothar R Schad
The aim of this study was to observe the effects of strophanthin induced inhibition of the Na-/K-ATPase in liver cells using a magnetic resonance (MR) compatible bioreactor. A microcavity array with a high density three-dimensional cell culture served as a functional magnetic resonance imaging (MRI) phantom for sodium multi quantum (MQ) spectroscopy. Direct contrast enhanced (DCE) MRI revealed the homogenous distribution of biochemical substances inside the bioreactor. NMR experiments using advanced bioreactors have advantages with respect to having full control over a variety of physiological parameters such as temperature, gas composition and fluid flow...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630930/real-time-quantitative-analysis-of-metabolic-flux-in-live-cells-using-a-hyperpolarized-micromagnetic-resonance-spectrometer
#2
Sangmoo Jeong, Roozbeh Eskandari, Sun Mi Park, Julio Alvarez, Sui Seng Tee, Ralph Weissleder, Michael G Kharas, Hakho Lee, Kayvan R Keshari
Metabolic reprogramming is widely considered a hallmark of cancer, and understanding metabolic dynamics described by the conversion rates or "fluxes" of metabolites can shed light onto biological processes of tumorigenesis and response to therapy. For real-time analysis of metabolic flux in intact cells or organisms, magnetic resonance (MR) spectroscopy and imaging methods have been developed in conjunction with hyperpolarization of nuclear spins. These approaches enable noninvasive monitoring of tumor progression and treatment efficacy and are being tested in multiple clinical trials...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28629281/noninvasive-quantitative-assessment-of-hepatic-steatosis-by-proton-magnetic-resonance-spectroscopy-among-adult-patients-receiving-home-parenteral-nutrition
#3
Angelique Huijbers, Geert Wanten, Helena Maria Dekker, Marinette van der Graaf
BACKGROUND: Intestinal failure-associated liver disease is a frequent complication in patients with chronic intestinal failure (CIF), with steatosis as a dominant feature in adults. Proton magnetic resonance spectroscopy (1H-MRS) is a noninvasive method to quantify liver fat content (LFC). In this study, LFC was assessed with 1H-MRS, taking into account the possible accumulation of paramagnetic components of home parenteral nutrition (HPN) that may disturb these measurements. METHODS: LFC was measured in 15 adult CIF patients who had been receiving HPN for >6 months...
June 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28624020/a-new-method-to-reduce-false-positive-results-in-breast-mri-by-evaluation-of-multiple-spectral-regions-in-proton-mr-spectroscopy
#4
Paola Clauser, Magda Marcon, Matthias Dietzel, Pascal A T Baltzer
OBJECTIVES: To investigate whether the evaluation of multiple spectral regions can increase the diagnostic performance of (1)H-MRS of the breast and reduce false positive findings. METHODS: 93 patients (mean age 56 years, range 23-79) undergoing breast MRI for routine clinical indications on a 1.5T scanner were eligible for this IRB-approved prospective study. Suspicious enhancing lesions ≥8mm underwent single-voxel point-resolved (1)H-MRS (PRESS, TR=2000ms, TE=272ms)...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28618085/improved-localization-spectral-quality-and-repeatability-with-advanced-mrs-methodology-in-the-clinical-setting
#5
Dinesh K Deelchand, Kejal Kantarci, Gülin Öz
PURPOSE: To investigate the utility of an advanced magnetic resonance spectroscopy (MRS) protocol in the clinical setting, and to compare the localization accuracy, spectral quality, and quantification repeatability between this advanced and the conventional vendor-provided MRS protocol on a clinical 3T platform. METHODS: Proton spectra were measured from the posterior cingulate cortices in 30 healthy elderly subjects by clinical MR technologists using a vendor-provided (point resolved spectroscopy with advanced 3D gradient-echo B0 shimming) and an advanced (semi-LASER with FAST(EST)MAP shimming) protocol, in random order...
June 15, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28609203/evaluation-of-hepatic-steatosis-by-using-acoustic-structure-quantification-us-in-a-rat-model-comparison-with-pathologic-examination-and-mr-spectroscopy
#6
Dong Ho Lee, Jae Young Lee, Kyung Bun Lee, Joon Koo Han
Purpose To determine factors that significantly affect the focal disturbance (FD) ratio calculated with an acoustic structure quantification (ASQ) technique in a dietary-induced fatty liver disease rat model and to assess the diagnostic performance of the FD ratio in the assessment of hepatic steatosis by using histopathologic examination as a standard of reference. Materials and Methods Twenty-eight male F344 rats were fed a methionine-choline-deficient diet with a variable duration (3.5 days [half week] or 1, 2, 3, 4, 5, or 6 weeks; four rats in each group)...
June 13, 2017: Radiology
https://www.readbyqxmd.com/read/28603480/how-energy-metabolism-supports-cerebral-function-insights-from-13-c-magnetic-resonance-studies-in-vivo
#7
REVIEW
Sarah Sonnay, Rolf Gruetter, João M N Duarte
Cerebral function is associated with exceptionally high metabolic activity, and requires continuous supply of oxygen and nutrients from the blood stream. Since the mid-twentieth century the idea that brain energy metabolism is coupled to neuronal activity has emerged, and a number of studies supported this hypothesis. Moreover, brain energy metabolism was demonstrated to be compartmentalized in neurons and astrocytes, and astrocytic glycolysis was proposed to serve the energetic demands of glutamatergic activity...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28596576/knee-subchondral-bone-perfusion-and-its-relationship-to-marrow-fat-and-trabeculation-on-multi-parametric-mri-and-micro-ct-in-experimental-ckd
#8
Chao-Ying Wang, Yu-Juei Hsu, Yi-Jen Peng, Herng-Sheng Lee, Yue-Cune Chang, Chih-Shan Chang, Shih-Wei Chiang, Yi-Chih Hsu, Ming-Huang Lin, Guo-Shu Huang
The pathogenesis of chronic kidney disease (CKD) is multifactorial. In the progression of CKD arthropathy, arteriosclerosis may alter the knee subchondral bone marrow by altering blood flow through the bone vasculature. Herein, multi-parametric MRI assessment, including dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), magnetic resonance spectroscopy (MRS), MRI T2*, contrast enhanced MR angiography (CE-MRA), and micro-CT were applied in a rodent nephrectomy model to: 1) investigate the blood perfusion of subchondral bone marrow and its relationship to fat water content and trabeculation pattern in CKD and 2) demonstrate the feasibility of using multi-parametric MRI parameters as imaging biomarkers to evaluate the disease's progression...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28589500/-mr-spectroscopy-for-clinical-diagnostics
#9
EDITORIAL
W Reith
No abstract text is available yet for this article.
June 2017: Der Radiologe
https://www.readbyqxmd.com/read/28583636/metabolic-profile-of-liver-damage-in-non-cirrhotic-virus-c-and-autoimmune-hepatitis-a-proton-decoupled-31-p-mrs-study
#10
Antti Hakkarainen, Lauri Puustinen, Reetta Kivisaari, Sonja Boyd, Urpo Nieminen, Perttu Arkkila, Nina Lundbom
PURPOSE: To study liver (31)P MRS, histology, transient elastography, and liver function tests in patients with virus C hepatitis (HCV) or autoimmune hepatitis (AIH) to test the hypothesis that (31)P MR metabolic profile of these diseases differ. MATERIALS AND METHODS: 25 patients with HCV (n=12) or AIH (n=13) underwent proton decoupled (31)P MRS spectroscopy performed on a 3.0T MR imager. Intensities of phosphomonoesters (PME) of phosphoethanolamine (PE) and phosphocholine (PC), phosphodiesters (PDE) of glycerophosphoethanolamine (GPE) and glycerophosphocholine (GPC), and γ, α and β resonances of adenosine triphosphate (ATP), and nicotinamide adenine dinucleotide phosphate (NADPH) were determined...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28570033/quantitative-mri-and-spectroscopy-of-bone-marrow
#11
REVIEW
Dimitrios C Karampinos, Stefan Ruschke, Michael Dieckmeyer, Maximilian Diefenbach, Daniela Franz, Alexandra S Gersing, Roland Krug, Thomas Baum
Bone marrow is one of the largest organs in the human body, enclosing adipocytes, hematopoietic stem cells, which are responsible for blood cell production, and mesenchymal stem cells, which are responsible for the production of adipocytes and bone cells. Magnetic resonance imaging (MRI) is the ideal imaging modality to monitor bone marrow changes in healthy and pathological states, thanks to its inherent rich soft-tissue contrast. Quantitative bone marrow MRI and magnetic resonance spectroscopy (MRS) techniques have been also developed in order to quantify changes in bone marrow water-fat composition, cellularity and perfusion in different pathologies, and to assist in understanding the role of bone marrow in the pathophysiology of systemic diseases (e...
June 1, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28562203/is-hepatic-triglyceride-content-associated-with-aortic-pulse-wave-velocity-and-carotid-intima-media-thickness-the-netherlands-epidemiology-of-obesity-study
#12
Ralph L Widya, Renée de Mutsert, Jos J M Westenberg, Karin B Gast, Martin den Heijer, Saskia le Cessie, Johannes W A Smit, J Wouter Jukema, Frits R Rosendaal, Albert de Roos, Hildo J Lamb
Purpose To test the hypothesis that hepatic triglyceride content is associated with subclinical vascular impairment and is not confounded by various cardiometabolic risk factors. Materials and Methods This study was approved by the institutional review board, and all participants gave written informed consent. In this cross-sectional analysis of baseline measurements of the Netherlands Epidemiology of Obesity study, a population-based cohort study, 1899 participants (52% men; mean age, 55 years ± 6 [standard deviation]) underwent magnetic resonance (MR) spectroscopy and MR imaging to assess hepatic triglyceride content, aortic pulse wave velocity (PWV), and visceral fat...
May 29, 2017: Radiology
https://www.readbyqxmd.com/read/28558795/non-caloric-sweetener-provides-magnetic-resonance-imaging-contrast-for-cancer-detection
#13
Puneet Bagga, Mohammad Haris, Kevin D'Aquilla, Neil E Wilson, Francesco M Marincola, Mitchell D Schnall, Hari Hariharan, Ravinder Reddy
BACKGROUND: Image contrast enhanced by exogenous contrast agents plays a crucial role in the early detection, characterization, and determination of the precise location of cancers. Here, we investigate the feasibility of using a non-nutritive sweetener, sucralose (commercial name, Splenda), as magnetic resonance imaging (MRI) contrast agent for cancer studies. METHODS: High-resolution nuclear-magnetic-resonance spectroscopy and MR studies on sucralose solution phantom were performed to detect the chemical exchange saturation transfer (CEST) property of sucralose hydroxyl protons with bulk water (sucCEST)...
May 30, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28557156/toward-hyperpolarized-19f-molecular-imaging-via-reversible-exchange-with-parahydrogen
#14
Roman V Shchepin, Boyd M Goodson, Thomas Theis, Warren S Warren, Eduard Y Chekmenev
Fluorine-19 has high NMR detection sensitivity-similar to that of protons, owing to its large gyromagnetic ratio and high natural abundance (100%). Unlike protons, however, fluorine-19 (19F) has a negligible occurrence in biological objects, as well as a more sensitive chemical shift. As a result, in vivo 19F NMR spectroscopy and MR imaging offer advantages of negligible background signal and sensitive reporting of the local molecular environment. Here we report on NMR hyperpolarization of 19F nuclei using reversible exchange reactions with parahydrogen gas as the source of nuclear spin order...
May 29, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28554547/the-influence-of-cardiac-triggering-time-and-an-optimization-strategy-for-improved-cardiac-mr-spectroscopy
#15
Åsa Carlsson, Maja C Sohlin, Kerstin M Lagerstrand, Eva Forsell Aronsson, Maria Ljungberg
PURPOSE: To study how cardiac motion affects the spectral quality in cardiac MR spectroscopy and to establish an optimization strategy for the cardiac triggering time for improved quality and success rate of cardiac MRS. METHOD: Water spectra were acquired while the cardiac triggering time was varied over the cardiac cycle, and five different spectral quality parameters were studied (frequency, phase, linewidth, amplitude and noise). Furthermore, three different optimization strategies for the cardiac triggering time were tested, and finally, a comparison was made between water suppressed lipid spectra acquired in systole and diastole...
May 26, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28552355/a-mechanistic-link-from-gaba-to-cortical-architecture-and-perception
#16
James Kolasinski, John P Logan, Emily L Hinson, Daniel Manners, Amir P Divanbeighi Zand, Tamar R Makin, Uzay E Emir, Charlotte J Stagg
Understanding both the organization of the human cortex and its relation to the performance of distinct functions is fundamental in neuroscience. The primary sensory cortices display topographic organization, whereby receptive fields follow a characteristic pattern, from tonotopy to retinotopy to somatotopy [1]. GABAergic signaling is vital to the maintenance of cortical receptive fields [2]; however, it is unclear how this fine-grain inhibition relates to measurable patterns of perception [3, 4]. Based on perceptual changes following perturbation of the GABAergic system, it is conceivable that the resting level of cortical GABAergic tone directly relates to the spatial specificity of activation in response to a given input [5-7]...
June 5, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28544651/genetic-determination-of-body-fat-distribution-and-the-attributive-influence-on-metabolism
#17
Ellen Fehlert, Róbert Wagner, Caroline Ketterer, Anja Böhm, Jürgen Machann, Louise Fritsche, Fausto Machicao, Fritz Schick, Harald Staiger, Norbert Stefan, Hans-Ulrich Häring, Andreas Fritsche, Martin Heni
OBJECTIVE: Genome-wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs) associated with estimates of body fat distribution. Using predefined risk allele scores, the correlation of these scores with precisely quantified body fat distribution assessed by magnetic resonance (MR) imaging techniques and with metabolic traits was investigated. METHODS: Data from 4,944 MR scans from 915 subjects of European ancestry were analyzed. Body fat distribution was determined by MR imaging and liver fat content by (1) H-MR spectroscopy...
May 25, 2017: Obesity
https://www.readbyqxmd.com/read/28540835/influence-of-temperature-on-cerebellar-metabolite-levels
#18
Zhicheng Yang, Jun Li
OBJECTIVE: The cerebellum is extremely sensitive to heat-induced injury because of the abundance of Purkinje cells. This study explored the influence of temperature on cerebellar metabolite levels by magnetic resonance spectroscopy (MRS). MATERIALS AND METHODS: Ten healthy volunteers were recruited to undergo a MRS examination in the summer and winter. Twenty-four ordinary patients with fever underwent the same examination during fever and after recovery. All MR spectras were recorded from the cerebellum...
June 7, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28536464/the-protective-effect-of-human-renal-sinus-fat-on-glomerular-cells-is-reversed-by-the-hepatokine-fetuin-a
#19
R Wagner, J Machann, M Guthoff, P P Nawroth, S Nadalin, M A Saleem, N Heyne, A Königsrainer, F Fend, F Schick, A Fritsche, N Stefan, H-U Häring, E Schleicher, D I Siegel-Axel
Renal sinus fat (RSF) is a perivascular fat compartment located around renal arteries. In this in vitro and in vivo study we hypothesized that the hepatokine fetuin-A may impair renal function in non alcoholic fatty liver disease (NAFLD) by altering inflammatory signalling in RSF. To study effects of the crosstalk between fetuin-A, RSF and kidney, human renal sinus fat cells (RSFC) were isolated and cocultured with human endothelial cells (EC) or podocytes (PO). RSFC caused downregulation of proinflammatory and upregulation of regenerative factors in cocultured EC and PO, indicating a protective influence of RFSC...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28533512/is-there-an-association-between-enhanced-choline-and-%C3%AE-catenin-pathway-in-breast-cancer-a-pilot-study-by-mr-spectroscopy-and-elisa
#20
Khushbu Agarwal, Gururao Hariprasad, Komal Rani, Uma Sharma, Sandeep R Mathur, Vurthaluru Seenu, Rajinder Parshad, Naranamangalam R Jagannathan
Total choline (tCho) was documented as a biomarker for breast cancer diagnosis by in vivo MRS. To understand the molecular mechanisms behind elevated tCho in breast cancer, an association of tCho with β-catenin and cyclin D1 was evaluated. Hundred fractions from 20 malignant, 10 benign and 20 non-involved breast tissues were isolated. Cytosolic and nuclear expressions of β-catenin and cyclin D1 were estimated using ELISA. Higher tCho was seen in malignant compared to benign tissues. Malignant tissues showed higher cytosolic and nuclear β-catenin expressions than benign and non-involved tissues...
May 22, 2017: Scientific Reports
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