keyword
https://read.qxmd.com/read/38506267/comparison-of-clinical-outcomes-of-several-risk-stratification-tools-in-newly-diagnosed-aml-patients-a-real-world-evidence-in-our-current-therapeutic-era
#1
JOURNAL ARTICLE
Alexandre Iat, Michael Loschi, Sami Benachour, Anne Calleja, Edmond Chiche, Isabelle Sudaka, Danièle Aquaronne, Corinne Ferrero, Laurène Fenwarth, Alice Marceau, Elise Fournier, Berengere Dadone-Montaudie, Thomas Cluzeau
BACKGROUND OF THE STUDY: AML classification tools have been developed to stratify the risk at AML diagnosis. There is a need to evaluate these tools in the current therapeutic era. COHORT CHARACTERISTICS: In this retrospective study, we compared five classifiers: ELN 2017, ELN 2022, ALFA classifier, Papaemmanuil et al. classifier, and Lindsley et al. classifier, in a real-life cohort of 281 patients newly diagnosed for AML in Nice University Hospital. In our cohort median age was 68 years old, sex ratio was M/F 56%/44%, performance status was lower than 2 in 73...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38470375/venetoclax-plus-a-hypomethylating-agent-versus-cytarabine-aclarubicin-and-granulocyte-colony-stimulating-factor-chemotherapy-as-a-first-line-therapy-for-newly-diagnosed-acute-myeloid-leukemia-a-propensity-score-matched-analysis
#2
JOURNAL ARTICLE
Rui Huang, Honghua He, Xiaoli Xu, Xiaonan Lin, Ying Dong, Xiaotao Wang, Fang Jiang, Pengcheng Huang, Shuyi Mo, Zhenqian Huang, Yaya Wang, Hongfang Tao, Yaling Zheng, Ming Wu, Chuting Yang, Ziyu Zheng, Ying Zhao, Yuming Zhang, Yuhua Li
BACKGROUND: Both venetoclax plus a hypomethylating agent (VEN/HMA) and cytarabine, aclarubicin, and granulocyte colony-stimulating factor (CAG) are low-intensity regimens for older patients with acute myeloid leukemia (AML) that show good efficacy and safety. It is unknown how VEN/HMA compares with the CAG regimen for the treatment of newly diagnosed AML. METHODS: The outcomes of patients with newly diagnosed AML treated with VEN/HMA were compared with those of patients treated with a CAG-based regimen...
March 12, 2024: Cancer
https://read.qxmd.com/read/38469782/development-of-a-low-cost-semiquantitative-polymerase-chain-reaction-assay-for-molecular-diagnosis-of-williams-syndrome
#3
JOURNAL ARTICLE
Dinali M Ranaweera, Deepthi C de Silva, Duminda Samarasinghe, Shehan Perera, Nirosha Kugalingam, Sumudu R Samarasinghe, Wadumesthri Y Madushani, Hiran H E Jayaweera, Siyath Gunewardene, Kajan Muneeswaran, Vaz S Gnanam, Naduviladath V Chandrasekharan
BACKGROUND: Williams Beuren Syndrome (WBS) is a well-recognized and common genetic cause of congenital heart defects, developmental delay, hypercalcemia, and characteristic facial features. It is caused by a 1.5 - 1.8 Mb heterozygous deletion of chromosome 7q11.23 with loss of around 28 coding genes. The aim of this study was to develop a low-cost, semi-quantitative PCR (sqPCR) method to detect the chromosome 7q11.23 deletion. METHODS: Twenty-four suspected WBS cases were recruited following ethical clearance and informed consent...
March 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38461563/microscopic-chemical-characterization-of-epoxy-resin-with-scanning-transmission-electron-microscopy-electron-energy-loss-spectroscopy
#4
JOURNAL ARTICLE
Hsin-Hui Huang, Tomohiro Miyata, Yohei K Sato, Teruyasu Mizoguchi, Hiroshi Jinnai, Kaname Yoshida
The structural characterization of epoxy resins is essential to improve the understanding on their structure-property relationship for promising high-performance applications. Among all analytical techniques, scanning transmission electron microscopy-electron energy-loss spectroscopy (STEM-EELS) is a powerful tool for probing the chemical and structural information of various materials at a high spatial resolution. However, for sensitive materials, such as epoxy resins, the structural damage induced by electron-beam irradiation limits the spatial resolution in the STEM-EELS analysis...
March 7, 2024: Micron
https://read.qxmd.com/read/38445193/severe-atopic-dermatitis-with-cutis-laxa-caused-by-a-variant-in-the-eln-gene
#5
Tatsuya Katsumi, Ryota Hayashi, Shingo Takei, Rei Yokoyama, Osamu Ansai, Satoru Shinkuma, Riichiro Abe
No abstract text is available yet for this article.
April 2024: JAAD Case Reports
https://read.qxmd.com/read/38438627/rop-et-a-prospective-phase-iii-trial-investigating-the-efficacy-and-safety-of-ropeginterferon-alfa-2b-in-essential-thrombocythemia-patients-with-limited-treatment-options
#6
JOURNAL ARTICLE
Jean-Jacques Kiladjian, Francisca Ferrer Marin, Haifa Kathrin Al-Ali, Alberto Alvarez-Larrán, Eloise Beggiato, Maria Bieniaszewska, Massimo Breccia, Veronika Buxhofer-Ausch, Olga Cerna, Ana-Manuela Crisan, Catalin Doru Danaila, Valerio De Stefano, Konstanze Döhner, Victoria Empson, Joanna Gora-Tybor, Martin Griesshammer, Sebastian Grosicki, Paola Guglielmelli, Valentin García-Gutierrez, Florian H Heidel, Arpád Illés, Ciprian Tomuleasa, Chloe James, Steffen Koschmieder, Maria-Theresa Krauth, Kurt Krejcy, Mihaela-Cornelia Lazaroiu, Jiri Mayer, Zsolt György Nagy, Franck-Emmanuel Nicolini, Francesca Palandri, Vassiliki Pappa, Andreas Johannes Reiter, Tomasz Sacha, Stefanie Schlager, Stefan Schmidt, Evangelos Terpos, Martin Unger, Albert Wölfler, Blanca Xicoy Cirici, Christoph Klade
Interferon-based therapies, such as ropeginterferon alfa-2b have emerged as promising disease-modifying agents for myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET). Current ET treatments aim to normalize hematological parameters and reduce the thrombotic risk, but they do not modify the natural history of the disease and hence, have no impact on disease progression. Ropeginterferon alfa-2b (trade name BESREMi®), a novel, monopegylated interferon alfa-2b with an extended administration interval, has demonstrated a robust and sustained efficacy in polycythemia vera (PV) patients...
March 4, 2024: Annals of Hematology
https://read.qxmd.com/read/38433437/prognostic-analysis-according-to-european-leukemianet-2022-risk-stratification-for-elderly-patients-with-acute-myeloid-leukemia-treated-with-decitabine
#7
JOURNAL ARTICLE
Mihee Kim, Seo-Yeon Ahn, TaeHyung Kim, Sung-Hoon Jung, Ga-Young Song, Deok-Hwan Yang, Je-Jung Lee, Mi Yeon Kim, Ju Heon Park, Myung-Geun Shin, Jae-Sook Ahn, Hyeoung-Joon Kim, Dennis Dong Hwan Kim
OBJECTIVES: This study aimed to evaluate the prognostic significance of the revised European LeukemiaNet (ELN)-2022 risk stratification model for 123 elderly acute myeloid leukemia (AML) patients treated with decitabine chemotherapy. RESULTS: Based on the ELN-2022 risk stratification, 15 (12.2%), 51 (41.5%), and 57 (46.3%) patients were classified as having favorable, intermediate, and high-risk AML, respectively. In comparison with the ELN-2017 risk stratification, the ELN-2022 risk stratification re-assigned 26 (21...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38422768/the-xpo1-inhibitor-selinexor-ameliorates-bleomycin-induced-pulmonary-fibrosis-in-mice-via-gbp5-nlrp3-inflammasome-signaling
#8
JOURNAL ARTICLE
Jia Zhang, Yihua Zhang, Qi Chen, Yong Qi, Xiaoju Zhang
Pulmonary fibrosis is an irreversible and progressive lung disease with limited treatments available. Selinexor (Sel), an orally available, small-molecule, selective inhibitor of XPO1, exhibits notable antitumor, anti-inflammatory and antiviral activities. However, its potential role in treating pulmonary fibrosis is unknown. C57BL/6J mice were used to establish a pulmonary fibrosis model by intratracheal administration of bleomycin (BLM). Subsequently, Sel was administered intraperitoneally. Our data demonstrated that Sel administration ameliorated BLM-induced pulmonary fibrosis by increasing mouse body weights; reducing H&E staining, Masson staining scores, and shadows in mouse lung computed tomography (CT) images, decreasing the total cell and neutrophil counts in the lung and bronchoalveolar lavage fluid (BALF); and decreasing the levels of TGF-β1...
February 28, 2024: International Immunopharmacology
https://read.qxmd.com/read/38411364/use-of-onenote-class-notebook-as-a-combined-electronic-laboratory-notebook-and-content-delivery-tool-in-an-introductory-biochemistry-laboratory-course
#9
JOURNAL ARTICLE
Ahlia Khan-Trottier
The COVID-19 pandemic has forced a shift in thinking regarding the safe delivery of wet laboratory courses. While we were fortunate to have the capacity to continue delivering wet laboratory experiments with physical distancing and other measures in place, modifications to the mechanisms of delivery within courses were necessary to minimize risk to students and teaching staff. One such modification was introduced in BCH370H, an introductory biochemistry laboratory course, where a OneNote Class Notebook (ONCN) was used as an electronic laboratory notebook (ELN) in place of the traditional hardbound paper laboratory notebook (PLN) used prior to the pandemic...
February 27, 2024: Biochemistry and Molecular Biology Education
https://read.qxmd.com/read/38398301/acute-myeloid-leukemia-post-cytotoxic-therapy-in-breast-cancer-survivors-over-23-years-of-single-center-analysis
#10
JOURNAL ARTICLE
Monika Adamska, Ewelina Kowal-Wiśniewska, Marta Barańska, Anna Przybyłowicz-Chalecka, Anna Łojko-Dankowska, Monika Joks, Małgorzata Jarmuż-Szymczak, Lidia Gil
Background : Acute myeloid leukemia post cytotoxic therapy (AML-pCT) among breast cancer (BC) survivors represents a life-threatening complication. This study aims to assess the clinical outcomes of AML-pCT post BC. Methods : An analysis of all AML patients treated at a single hematology center (2000-2023) was performed to select patients with AML-pCT post BC. We applied the 2022 ELN criteria to define the genetic risk. Results : Among 847 AML patients, 28 were diagnosed with AML-pCT following BC. Complex karyotype (CK) occurred in 23...
February 8, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38396545/transcriptome-data-revealed-the-circrna-mirna-mrna-regulatory-network-during-the-proliferation-and-differentiation-of-myoblasts-in-shitou-goose
#11
JOURNAL ARTICLE
Rongqin Huang, Jiahui Chen, Xu Dong, Xiquan Zhang, Wen Luo
CircRNA, a recently characterized non-coding RNA (ncRNA) variant, functions as a molecular sponge, exerting regulatory control by binding to microRNA (miRNA) and modulating the expression of downstream proteins, either promoting or inhibiting their expression. Among poultry species, geese hold significant importance, prized by consumers for their delectable taste and rich nutritional content. Despite the prominence of geese, research on the growth and development of goose muscle, particularly the regulatory role of circRNAs in goose muscle formation, remains insufficiently explored...
February 8, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38396145/venetoclax-with-decitabine-or-azacitidine-in-relapsed-or-refractory-acute-myeloid-leukemia
#12
JOURNAL ARTICLE
Ian M Bouligny, Graeme Murray, Michael Doyel, Tilak Patel, Josh Boron, Valerie Tran, Juhi Gor, Yiwei Hang, Yanal Alnimer, Thuy Ho, Kyle Zacholski, Chad Venn, Nolan A Wages, Steven Grant, Keri R Maher
Relapsed or refractory acute myeloid leukemia (AML) is associated with poor outcomes and resistance to therapy. The addition of venetoclax, a BCL-2 antagonist, to lower-intensity therapies results in improved survival in the first-line setting compared to monotherapy with a hypomethylating agent or low-dose cytarabine. Despite this, much remains unknown about the performance of venetoclax with a hypomethylating agent following the first-line setting. Additionally, while the ELN 2022 guidelines appear to improve the prognostication of AML, clarification is needed to determine how the revision applies to lower-intensity strategies...
February 23, 2024: Medical Oncology
https://read.qxmd.com/read/38388649/chronic-myeloid-leukemia-diagnosed-in-pregnancy-management-and-outcome-of-87-patients-reported-to-the-european-leukemianet-international-registry
#13
JOURNAL ARTICLE
Ekaterina Chelysheva, Jane Apperley, Anna Turkina, Mohamed A Yassin, Delphine Rea, Franck E Nicolini, Daniela Barraco, Khamida Kazakbaeva, Sukhrob Saliev, Adi Shacham Abulafia, Salam Al-Kindi, Jennifer Byrne, Harry F Robertson, Marco Cerrano, Roman Shmakov, Evgenia Polushkina, Paolo de Fabritiis, Malgorzata Monika Trawinska, Elisabetta Abruzzese
The management of chronic myeloid leukemia (CML) diagnosed during pregnancy is a rare and challenging situation. We report the treatment and outcome of 87 cases diagnosed in chronic phase from 2001-2022 derived from the largest international observational registry, supported by the European LeukemiaNet (ELN), of 400 pregnancies in 299 CML women. Normal childbirth occurred in 76% without an increased rate of birth abnormalities or life-threatening events, including in patients untreated or treated with interferon-α and/or imatinib in 2nd-3rd trimester...
February 23, 2024: Leukemia
https://read.qxmd.com/read/38368935/differential-effects-of-sorl1-deficiency-on-the-endo-lysosomal-network-in-human-neurons-and-microglia
#14
REVIEW
Swati Mishra, Suman Jayadev, Jessica E Young
The endosomal gene SORL1 is a strong Alzheimer's disease (AD) risk gene that harbours loss-of-function variants causative for developing AD. The SORL1 protein SORL1/SORLA is an endosomal receptor that interacts with the multi-protein sorting complex retromer to traffic various cargo through the endo-lysosomal network (ELN). Impairments in endo-lysosomal trafficking are an early cellular symptom in AD and a novel therapeutic target. However, the cell types of the central nervous system are diverse and use the ELN differently...
April 8, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/38367765/analytical-validation-of-a-37-gene-next-generation-sequencing-panel-for-myeloid-malignancies-and-review-of-initial-findings-including-reclassification-of-acute-myeloid-leukemias-and-myelodysplastic-syndromes-using-the-2022-who-icc-eln-guidelines
#15
JOURNAL ARTICLE
Becky Leung, Hnin Aung, Adayapalam Nandini, Ghusoon Abdulrasool, Chiyan Lau, Louise Seymour
Myeloid neoplasms are clonal disorders that arise via acquisition of genetic mutations leading to excessive proliferation and defective differentiation. Mutational profiling is vital as it has implications on diagnosis, prognosis, and therapeutic decision making. Next generation sequencing (NGS) has become a mainstay in the evaluation of myeloid malignancies, as it enables efficient characterisation of multiple genetic changes. Herein the analytical validation of the 37-gene Archer VariantPlex Core Myeloid panel is reported, using 58 DNA specimens with 87 single nucleotide variants (SNV) and 23 insertions/deletions (INDEL)...
February 15, 2024: Journal of Molecular Diagnostics: JMD
https://read.qxmd.com/read/38353503/lysyl-oxidase-mediated-elastin-upregulation-promotes-the-proliferation-and-migration-of-human-retinal-endothelial-cells
#16
JOURNAL ARTICLE
Yu Zhang, Yurong Zhang, Siyu He, Weixing Wang
BACKGROUND: Proliferative diabetic retinopathy (PDR) is a major cause of irreversible blindness in the working age population. The dysfunction of retinal vascular endothelial cells (RVECs) is the primary cause of PDR. Extracellular matrix (ECM) accumulation promotes intracellular signaling required for RVEC proliferation, migration, survival, and tube morphogenesis. OBJECTIVES: This study aimed to investigate the role of lysyl oxidase (LOX) in the cellular function of RVECs and PDR pathogenesis and to identify the underlying mechanisms...
February 14, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38353072/prognostic-value-of-nodal-staging-classification-and-number-of-examined-lymph-nodes-among-patients-with-ampullary-cancer
#17
JOURNAL ARTICLE
Vivian Resende, Yutaka Endo, Muhammad Musaab Munir, Mujtaba Khalil, Zayed Rashid, Henrique Araújo Lima, Karol Rawicz-Pruszyński, Muhammad Muntazir Mehdi Khan, Erryk Katayama, Diamantis I Tsilimigras, Timothy M Pawlik
BACKGROUND: Metastatic disease in the regional lymph nodes (LNs) is a strong indicator of worse outcomes among patients after curative-intent resection of ampullary cancer (AC). This study aimed to ascertain the threshold number of examined LNs (ELNs) for AC to compare the prognosis accuracy of various nodal classification schemes relative to long-term prognosis. METHODS: Patients who underwent pancreatoduodenectomy (PD) for AC (2004-2019) were identified using the National Cancer Database...
January 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38348657/molecular-and-spatial-signatures-of-mouse-embryonic-endothelial-cells-at-single-cell-resolution
#18
JOURNAL ARTICLE
Jian Chen, Xiaoran Zhang, Daniel Morris DeLaughter, Michael A Trembley, Shaila Saifee, Feng Xiao, Jiehui Chen, Pingzhu Zhou, Christine E Seidman, Jonathan G Seidman, William T Pu
BACKGROUND: Mature endothelial cells (ECs) are heterogeneous, with subtypes defined by tissue origin and position within the vascular bed (ie, artery, capillary, vein, and lymphatic). How this heterogeneity is established during the development of the vascular system, especially arteriovenous specification of ECs, remains incompletely characterized. METHODS: We used droplet-based single-cell RNA sequencing and multiplexed error-robust fluorescence in situ hybridization to define EC and EC progenitor subtypes from E9...
February 13, 2024: Circulation Research
https://read.qxmd.com/read/38344437/plant-derived-exosome-like-nanoparticles-emerging-nanosystems-for-enhanced-tissue-engineering
#19
REVIEW
Hui Feng, Yang Yue, Yan Zhang, Jingqi Liang, Liang Liu, Qiong Wang, Qian Feng, Hongmou Zhao
Tissue engineering holds great potential for tissue repair and rejuvenation. Plant-derived exosome-like nanoparticles (ELNs) have recently emerged as a promising avenue in tissue engineering. However, there is an urgent need to understand how plant ELNs can be therapeutically applied in clinical disease management, especially for tissue regeneration. In this review, we comprehensively examine the properties, characteristics, and isolation techniques of plant ELNs. We also discuss their impact on the immune system, compatibility with the human body, and their role in tissue regeneration...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38339429/new-approaches-for-the-treatment-of-aml-beyond-the-7-3-regimen-current-concepts-and-new-approaches
#20
REVIEW
Jaime L Roman Diaz, Mariola Vazquez Martinez, Farhad Khimani
Fifty years have passed since the development of the first chemotherapy regimen for treating acute myelogenous leukemia (AML), with the approval in 1973 of the cytarabine daunorubicin (7+3) regimen. Until recently, patients diagnosed with AML had very limited treatment options and depended primarily on chemotherapy in combinations, doses, or schedules of the same drugs. Patients with advanced age, comorbidities, or relapsed or refractory disease were left with no effective options for treatment. New advances in the understanding of the biology and the molecular and genetic changes associated with leukemogenesis, as well as recent advances in drug development, have resulted in the introduction over the last few years of novel therapeutic agents and approaches to the treatment of AML as well as a new classification of the disease...
February 5, 2024: Cancers
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