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Schistosoma and trypanosoma

Adrián Sánchez-Montalvá, Fernando Salvador, Isabel Ruiz-Camps, Pere Barba, David Valcárcel, Elena Sulleiro, Enrique Sanz-García, Israel Molina
Reactivation of latent imported infections has been periodically reported in migrant patients undergoing immunosuppression. We performed a prospective study at Vall d'Hebron University Hospital (Barcelona, Spain). Migrant patients over 16 years with the diagnosis of any oncohematologic disease were included. Patients were tested for soil-transmitted helminths, hepatitis virus, and human immunodeficiency virus, Treponema pallidum, human T-cell lymphotropic virus, latent tuberculosis infection, Toxoplasma spp...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
Marie C M Halliez, André G Buret
Gastrointestinal motility and transport of water and electrolytes play key roles in the pathophysiology of diarrhea upon exposure to enteric parasites. These processes are actively modulated by the enteric nervous system (ENS), which includes efferent, and afferent neurons, as well as interneurons. ENS integrity is essential to the maintenance of homeostatic gut responses. A number of gastrointestinal parasites are known to cause disease by altering the ENS. The mechanisms remain incompletely understood. Cryptosporidium parvum, Giardia duodenalis (syn...
2015: Frontiers in Cellular Neuroscience
Jelena Melesina, Dina Robaa, Raymond J Pierce, Christophe Romier, Wolfgang Sippl
Histone deacetylases (HDACs) are promising epigenetic targets for the treatment of various diseases, including cancer and neurodegenerative disorders. There is evidence that they can also be addressed to treat parasitic infections. Recently, the first X-ray structure of a parasite HDAC was published, Schistosoma mansoni HDAC8, giving structural insights into its inhibition. However, most of the targets from parasites of interest still lack this structural information. Therefore, we prepared homology models of relevant parasitic HDACs and compared them to human and S...
November 2015: Journal of Molecular Graphics & Modelling
Benetode Konziase
In this data article, we described the synthetic routes to four biotinylated probes (2, 3, 4, and 5) of artemisinin and the associated experimental procedures. We also provided the physical data for the synthesized compounds. These synthesized biotinylated probes of artemisinin are useful molecular tools for the affinity-labeling study of target receptor proteins of artemisinin in tropical pathogens such as Trypanosoma, Leishmania, and Schistosoma. The data provided herein are related to "Biotinylated probes of artemisinin with labeling affinity toward Trypanosoma brucei brucei target proteins", by Konziase (Anal...
September 2015: Data in Brief
Nayara Cristina Fonseca, Luana Faria da Cruz, Filipe da Silva Villela, Glaécia Aparecida do Nascimento Pereira, Jair Lage de Siqueira-Neto, Danielle Kellar, Brian M Suzuki, Debalina Ray, Thiago Belarmino de Souza, Ricardo José Alves, Policarpo Ademar Sales Júnior, Alvaro José Romanha, Silvane Maria Fonseca Murta, James H McKerrow, Conor R Caffrey, Renata Barbosa de Oliveira, Rafaela Salgado Ferreira
The pressing need for better drugs against Chagas disease, African sleeping sickness, and schistosomiasis motivates the search for inhibitors of cruzain, rhodesain, and Schistosoma mansoni CB1 (SmCB1), the major cysteine proteases from Trypanosoma cruzi, Trypanosoma brucei, and S. mansoni, respectively. Thiosemicarbazones and heterocyclic analogues have been shown to be both antitrypanocidal and inhibitory against parasite cysteine proteases. A series of compounds was synthesized and evaluated against cruzain, rhodesain, and SmCB1 through biochemical assays to determine their potency and structure-activity relationships (SAR)...
May 2015: Antimicrobial Agents and Chemotherapy
Zhiyue Lv, Zhongdao Wu, Limei Zhang, Pengyu Ji, Yifeng Cai, Shiqi Luo, Hongxi Wang, Hao Li
Parasites including helminthes, protozoa, and medical arthropod vectors are a major cause of global infectious diseases, affecting one-sixth of the world's population, which are responsible for enormous levels of morbidity and mortality important and remain impediments to economic development especially in tropical countries. Prevalent drug resistance, lack of highly effective and practical vaccines, as well as specific and sensitive diagnostic markers are proving to be challenging problems in parasitic disease control in most parts of the world...
February 2015: Parasitology Research
Ana Carolina Pereira, Viviane Rodrigues Esperandim, Daniele Ferreira da Silva, Daniele da Silva Ferreira, Lizandra Guidi Magalhães, Thais Coelho Lima, Dhammika N P Nanayakkara, Wilson Roberto Cunha, Jairo Kenupp Bastos, Márcio Luis Andrade e Silva
Parasitic diseases continue to be a major worldwide health problem, and there is an urgent need for development of therapeutic drugs. This paper describes synthesis of dehydrodiferulic acid dilactone 1 and dehydrodisinapic acid dilactone 2 furofuran lignans by oxidative coupling of ferulic and sinapic acids, respectively. Their schistosomicidal, trypanocidal, and leishmanicidal activities were evaluated in vitro against Schistosoma mansoni adult worms, trypomastigote and amastigotes forms of Trypanosoma cruzi, and promastigote forms of Leishmania amazonensis...
November 2014: Phytochemistry
Oscar Flórez-Vargas, Michael Bramhall, Harry Noyes, Sheena Cruickshank, Robert Stevens, Andy Brass
There is a growing concern both inside and outside the scientific community over the lack of reproducibility of experiments. The depth and detail of reported methods are critical to the reproducibility of findings, but also for making it possible to compare and integrate data from different studies. In this study, we evaluated in detail the methods reporting in a comprehensive set of trypanosomiasis experiments that should enable valid reproduction, integration and comparison of research findings. We evaluated a subset of other parasitic (Leishmania, Toxoplasma, Plasmodium, Trichuris and Schistosoma) and non-parasitic (Mycobacterium) experimental infections in order to compare the quality of method reporting more generally...
2014: PloS One
Jillian T Detwiler, Charles D Criscione
Little attention has been given to the role that introgression and hybridization have played in the evolution of parasites. Most studies are host-centric and ask if the hybrid of a free-living species is more or less susceptible to parasite infection. Here we focus on what is known about how introgression and hybridization have influenced the evolution of protozoan and helminth parasites of animals. There are reports of genome or gene introgression from distantly related taxa into apicomplexans and filarial nematodes...
2010: Genes
Sonali Shinde, Milsee Mol, Virashree Jamdar, Shailza Singh
Leishmania major causes cutaneous form of Leishmaniasis affecting 21 million people in developing countries. Overuse of the chemotherapeutics against leishmaniasis has resulted in the development of drug resistance in the parasite. To surmount this emerging threat we have attempted to target the surface molecules. Glycosylphosphatidylinositol is one such molecule that is present abundantly and thus our work revolves around the enzyme mannosyltransferase (GPI 14), an enzyme essential to add mannose on the glycosylphosphatidyl...
June 21, 2014: Journal of Theoretical Biology
Juliana de Almeida Pachioni, Juliana Gallottini Magalhães, Elys Juliane Cardoso Lima, Luciana de Moura Bueno, Joyce Ferreira Barbosa, Matheus Malta de Sá, Carlota Oliveira Rangel-Yagui
PURPOSE: Since when alkylphospholipds (ALPs) were discovered and, even further after miltefosine's approval for the treatment of cutaneous metastasis of breast cancer and leishmaniasis, their activity against many other diseases have been extensively studied. This review aims to provide a summary of the alkylphospholipids' applications investigated so far. RESULTS: The mechanism of action of ALPs is not fully understood, however it is believed that they interfere with lipid homeostasis leading to cell apoptosis...
2013: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Viviane Rodrigues Esperandim, Daniele da Silva Ferreira, Karen Cristina Sousa Rezende, Lizandra Guidi Magalhães, Julia Medeiros Souza, Patrícia Mendonça Pauletti, Ana Helena Januário, Rosangela da Silva de Laurentz, Jairo Kenupp Bastos, Guilherme Venâncio Símaro, Wilson Roberto Cunha, Márcio Luis Andrade E Silva
Protozoans of the trypanosomatid family cause the neglected tropical diseases leishmaniasis and trypanosomiasis, for which few drugs are available. In this context our group has recently reported that the essential oil obtained by steam distillation of the fruits of Piper cubeba is active against Schistosoma mansoni. Therefore, we have investigated the in vitro effects of the essential oil against the trypomastigote and amastigote forms of Trypanosoma cruzi isolated from an LLCMK₂ cell line culture and the promastigote forms of Leishmania amazonensis...
November 2013: Planta Medica
Yan Zhang, Jing-Yi Mi, Yong-Jun Rui, Yong-Liang Xu, Wei Wang
Stem cell therapy is an interventional treatment that introduces new cells into damaged tissues, which help in treating many diseases and injuries. It has been proved that stem cell therapy is effective for the treatment of cancers, diabetes mellitus, Parkinson's disease, Huntington's disease, cardiovascular diseases, neurological disorders, and many other diseases. Recently, stem cell therapy has been introduced to treat parasitic infections. The culture supernatant of mesenchymal stem cells (MSCs) is found to inhibit activation and proliferation of macrophages induced by the soluble egg antigen of Schistosoma japonicum, and MSC treatment relieves S...
February 2014: Parasitology Research
A P Mountford
This editorial highlights some of the key points made in the six invited reviews in this special issue of Parasite Immunology on the use of contemporary imaging technologies to investigate the parasite: host interface. Three of the reviews deal with the protozoa Trypanosoma, Leishmania, and Plasmodium, whilst the remainder focus on helminth parasites particularly Schistosoma. The reviews cover aspects related to how the development of transgenic parasites has vastly advanced our understanding of how parasites interact with host cells, particularly as a cause of pathology...
September 2013: Parasite Immunology
Fernando Salvador, Israel Molina, Elena Sulleiro, Joaquín Burgos, Adrián Curran, Eva Van den Eynde, Sara Villar del Saz, Jordi Navarro, Manuel Crespo, Inma Ocaña, Esteve Ribera, Vicenç Falcó, Albert Pahissa
Latent parasitic infections can reactivate because of immunosuppression. We conducted a prospective observational study of all human immunodeficiency virus (HIV)-infected immigrants who visited the Infectious Diseases Department of the Hospital Universitari Vall d'Hebron, Barcelona, Spain, during June 2010-May 2011. Screening of the most prevalent tropical diseases (intestinal parasitosis, Chagas disease, leishmaniasis, malaria, schistosomiasis, and strongyloidiasis) was performed according to geographic origin...
June 2013: American Journal of Tropical Medicine and Hygiene
J Finsterer, H Auer
Cerebral involvement in parasitoses is an important clinical manifestation of most of the human parasitoses. Parasites that have been described to affect the central nervous system (CNS), either as the dominant or as a collateral feature, include cestodes (Taenia solium (neurocysticerciasis), Echinococcus granulosus (cerebral cystic echinococcosis), E. multilocularis (cerebral alveolar echinococcosis), Spirometra mansoni (neurosparganosis)), nematodes (Toxocara canis and T. cati (neurotoxocariasis), Trichinella spiralis (neurotrichinelliasis), Angiostrongylus cantonensis and A...
September 2013: Journal of Helminthology
Chuanhuan Deng, Jiufeng Sun, Xuerong Li, Lexun Wang, Xuchu Hu, Xiaoyun Wang, Wenjun Chen, Xiaoli Lv, Chi Liang, Wenfang Li, Yan Huang, Ran Li, Zhongdao Wu, Xinbing Yu, Jin Xu
Aminopeptidases serve vital roles in metabolism of hormones, neurotransmission, turnover of proteins and immunological regulations. Leucine aminopeptidases catalyze the hydrolysis of amino-acid residues from the N-terminus of proteins and peptides. In the present study, leucine aminopeptidase 2 (LAP2) gene of Clonorchis sinensis (C. sinensis) was isolated and identified from an adult cDNA library of C. sinensis. Recombinant CsLAP2 was expressed and purified in Escherichia coli BL21. The open reading frame of LAP2 contains 1,560 bp equivalent to 519 amino acids, a similarity analysis showed a relatively low homology with Homo sapiens (19...
October 2012: Molecular Biology Reports
Fiona M Sansom
Nucleoside triphosphate diphosphohydrolases (NTPDases, GDA1_CD39 protein superfamily) play a diverse range of roles in a number of eukaryotic organisms. In humans NTPDases function in regulating the inflammatory and immune responses, control of vascular haemostasis and purine salvage. In yeast NTPDases are thought to function primarily in the Golgi, crucially involved in nucleotide sugar transport into the Golgi apparatus and subsequent protein glycosylation. Although rare in bacteria, in Legionella pneumophila secreted NTPDases function as virulence factors...
July 2012: Parasitology
Humberto Gonçalves Bertão, Renata Alexandre Ramos da Silva, Rafael José R Padilha, Mônica Camelo Pessôa de Azevedo Albuquerque, Gandhi Rádis-Baptista
Schistosomiasis is an infectious parasitic disease caused by helminths from the genus Schistosoma; it affects over 200 million people globally and is endemic in 70 countries. In Brazil, 6 million individuals are infected with Schistosoma mansoni. Furthermore, as the prevalence of S. mansoni infections is increasing, approximately 26 million citizens in 19 Brazilian states are at risk for infection. Schistosomiasis disease control involves predominately the administration of a single drug, praziquantel. Although praziquantel exhibits chemotherapeutic efficacy and safety, its massive use in endemic zones, the possibility of the emergence of drug-resistant Schistosoma parasites, and the lack of another efficacious antischistosomal drug demand the discovery of new schistosomicidal compounds...
June 2012: Parasitology Research
Qing-Ming Kong, Shao-Hong Lu, Qun-Bo Tong, Di Lou, Rui Chen, Bin Zheng, Takashi Kumagai, Li-Yong Wen, Nobuo Ohta, Xiao-Nong Zhou
BACKGROUND: Toxoplasmosis is a widespread zoonotic parasitic disease that occurs in both animals and humans. Traditional molecular assays are often difficult to perform, especially for the early diagnosis of Toxoplasma gondii infections. Here, we established a novel loop-mediated isothermal amplification targeting the 529 bp repeat element (529 bp-LAMP) to detect T. gondii DNA in blood samples of experimental mice infected with tachyzoites of the RH strain. FINDINGS: The assay was performed with Bst DNA polymerase at 65°C for 1 h...
2012: Parasites & Vectors
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