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David C Whitcomb

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https://www.readbyqxmd.com/read/30113427/germline-variants-and-risk-for-pancreatic-cancer-a-systematic-review-and-emerging-concepts
#1
Wei Zhan, Celeste A Shelton, Phil J Greer, Randall E Brand, David C Whitcomb
Pancreatic cancer requires many genetic mutations. Combinations of underlying germline variants and environmental factors may increase the risk of cancer and accelerate the oncogenic process. We systematically reviewed, annotated, and classified previously reported pancreatic cancer-associated germline variants in established risk genes. Variants were scored using multiple criteria and binned by evidence for pathogenicity, then annotated with published functional studies and associated biological systems/pathways...
September 2018: Pancreas
https://www.readbyqxmd.com/read/30101991/nutrition-and-inflammatory-biomarkers-in-chronic-pancreatitis-patients
#2
Julia B Greer, Phil Greer, Bimaljit S Sandhu, Samer Alkaade, C Mel Wilcox, Michelle A Anderson, Stuart Sherman, Timothy B Gardner, Michele D Lewis, Nalini M Guda, Thiruvengadam Muniraj, Darwin Conwell, Gregory A Cote, Christopher E Forsmark, Peter A Banks, Gong Tang, Kim Stello, Andres Gelrud, Randall E Brand, Adam Slivka, David C Whitcomb, Dhiraj Yadav
BACKGROUND: Chronic pancreatitis (CP) patients frequently experience malabsorption and maldigestion, leading to micronutrient and macronutrient deficiencies. Comorbid diabetes and lifestyle habits, such as alcohol consumption, may impact nutrition status. METHODS: We compared micronutrient antioxidant, bone metabolism, serum protein, and inflammatory marker levels in 301 CP patients and 266 controls with no known pancreatic disease. We analyzed serum prealbumin and retinol binding protein; vitamins A, D, E, and B12; osteocalcin; tumor necrosis factor-α; and C-reactive protein (CRP)...
August 13, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/30018304/hereditary-pancreatitis-in-the-united-states-survival-and-rates-of-pancreatic-cancer
#3
Celeste A Shelton, Chandraprakash Umapathy, Kimberly Stello, Dhiraj Yadav, David C Whitcomb
OBJECTIVES: Hereditary pancreatitis (HP), an autosomal dominant disease typically caused by mutations in PRSS1, has a broad range of clinical characteristics and high cumulative risk of pancreatic cancer. We describe survival and pancreatic cancer risk in the largest HP cohort in the US. METHODS: HP probands and family members prospectively recruited from 1995 to 2013 completed medical and family history questionnaires, and provided blood for DNA testing. Overall survival (until 12/31/2015) was determined from the Social Security Death Index (SSDI), National Death Index (NDI), and family members...
July 18, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29967636/overweight-or-obese-individuals-at-eighteen-years-of-age-develop-pancreatic-adenocarcinoma-at-a-significantly-earlier-age
#4
David T Chao, Nilesh H Shah, Herbert J Zeh, Aatur D Singhi, Nathan Bahary, Kevin M McGrath, Kenneth E Fasanella, Amer H Zureikat, David C Whitcomb, Randall E Brand
Background: Adolescent obesity is a national epidemic that recently has been shown to increase risk for pancreatic adenocarcinoma (PC) and is associated with an earlier age of PC onset. We hypothesized that PC patients who are overweight or obese at age 18 would have an earlier age of PC onset. Methods: Retrospective review of 531 patients in our PC registry was completed. Self-reported weight at age 18 and maximum lifetime weight were used to calculate body mass index (BMI) at age 18 (BMI-18) and maximum lifetime BMI...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29894415/recurrent-acute-pancreatitis-international-state-of-the-science-conference-with-recommendations
#5
Nalini M Guda, Venkata Muddana, David C Whitcomb, Philippe Levy, Pramod Garg, Gregory Cote, Aliye Uc, Shyam Varadarajulu, Santhi S Vege, Suresh T Chari, Chris E Forsmark, Dhiraj Yadav, D Nageshwar Reddy, Scott Tenner, Colin D Johnson, Fatih Akisik, Ashok K Saluja, Markus M Lerch, J Shawn Mallery, Martin L Freeman
Recurrent acute pancreatitis (RAP) is a clinically significant problem globally. The etiology remains unclear in approximately 10% to 15% of patients despite a thorough workup. Data on natural history and efficacy of treatments are limited. We aimed to establish criteria for diagnosis, evaluate the causative factors, and arrive at a consensus on the appropriate workup and management of patients with RAP. The organizing committee was formed, and a set of questions was developed based on the current evidence, controversies, and topics that needed further research...
July 2018: Pancreas
https://www.readbyqxmd.com/read/29867178/recurrent-acute-pancreatitis-significantly-reduces-quality-of-life-even-in-the-absence-of-overt-chronic-pancreatitis
#6
Gregory A Coté, Dhiraj Yadav, Judah A Abberbock, David C Whitcomb, Stuart Sherman, Bimaljit S Sandhu, Michelle A Anderson, Michele D Lewis, Samer Alkaade, Vikesh K Singh, John Baillie, Peter A Banks, Darwin Conwell, Nalini M Guda, Thiruvengadam Muniraj, Gong Tang, Randall Brand, Andres Gelrud, Stephen T Amann, Christopher E Forsmark, C Mel Wilcox, Adam Slivka, Timothy B Gardner
OBJECTIVES: The impact of recurrent acute pancreatitis (RAP) on quality of life (QOL) is unknown. We hypothesized that RAP would reduce QOL even in the absence of chronic pancreatitis (CP). METHODS: Data were pooled from three prospective, cross-sectional studies conducted across 27 U.S. centers (the North American Pancreatitis Studies); these included subjects with chronic pancreatitis (n = 1086), RAP alone (n = 508), and non-disease controls (n = 1025)...
June 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29859674/known-genetic-susceptibility-factors-for-chronic-pancreatitis-in-patients-of-european-ancestry-are-rare-in-patients-of-african-ancestry
#7
Anna Evans Phillips, Jessica LaRusch, Phil Greer, Judah Abberbock, Samer Alkaade, Stephen T Amann, Michelle A Anderson, John Baillie, Peter A Banks, Randall E Brand, Darwin Conwell, Gregory A Coté, Christopher E Forsmark, Timothy B Gardner, Andres Gelrud, Nalini Guda, Michele Lewis, Mary E Money, Thiruvengadam Muniraj, Bimaljit S Sandhu, Stuart Sherman, Vikesh K Singh, Adam Slivka, Gong Tang, C Mel Wilcox, David C Whitcomb, Dhiraj Yadav
BACKGROUND: Multiple pathogenic genetic variants are associated with pancreatitis in patients of European (EA) and Asian ancestries, but studies on patients of African ancestry (AA) are lacking. We evaluated the prevalence of known genetic variations in African-American subjects in the US. METHODS: We studied prospectively enrolled controls (n = 238) and patients with chronic (CP) (n = 232) or recurrent acute pancreatitis (RAP) (n = 45) in the NAPS2 studies from 2000-2014 of self-identified AA...
May 19, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29793839/international-consensus-statements-on-early-chronic-pancreatitis-recommendations-from-the-working-group-for-the-international-consensus-guidelines-for-chronic-pancreatitis-in-collaboration-with-the-international-association-of-pancreatology-american-pancreatic
#8
David C Whitcomb, Tooru Shimosegawa, Suresh T Chari, Christopher E Forsmark, Luca Frulloni, Pramod Garg, Peter Hegyi, Yoshiki Hirooka, Atsushi Irisawa, Takuya Ishikawa, Shuiji Isaji, Markus M Lerch, Philippe Levy, Atsushi Masamune, Charles M Wilcox, John Windsor, Dhiraj Yadav, Andrea Sheel, John P Neoptolemos
BACKGROUND: Chronic pancreatitis (CP) is a progressive inflammatory disorder currently diagnosed by morphologic features. In contrast, an accurate diagnosis of Early CP is not possible using imaging criteria alone. If this were possible and early treatment instituted, the later, irreversible features and complications of CP could possibly be prevented. METHOD: An international working group supported by four major pancreas societies (IAP, APA, JPS, and EPC) and a PancreasFest working group sought to develop a consensus definition and diagnostic criteria for Early CP...
May 21, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29610511/response-to-culetto-et-al
#9
Niloofar Y Jalaly, David C Whitcomb, Vikesh K Singh
No abstract text is available yet for this article.
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29215631/which-patients-with-mild-acute-pancreatitis-require-prolonged-hospitalization
#10
Harkirat Singh, Amir Gougol, Rawad Mounzer, Dhiraj Yadav, Efstratios Koutroumpakis, Adam Slivka, David C Whitcomb, Georgios I Papachristou
OBJECTIVES: In our experience, a subset of mild acute pancreatitis (AP) patients, as defined by the Revised Atlanta Classification, has longer than expected hospitalization. Our aims are to report the prevalence of patients with mild AP who have a prolonged length of stay (LOS), evaluate the etiology, thoroughly phenotype, and finally compare this subset to those with expected LOS. METHODS: Patients admitted with AP from 2003 to 2015 were prospectively enrolled into this cohort study...
December 7, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29215544/the-251-a-t-polymorphism-in-the-il8-promoter-is-a-risk-factor-for-acute-pancreatitis
#11
Shrinivas Bishu, Efstratios Koutroumpakis, Rawad Mounzer, Kimberly Stello, Nijole Pollock, Anna Evans, David C Whitcomb, Georgios I Papachristou
OBJECTIVES: Inflammation in the setting of acute pancreatitis (AP) is partially driven by pathogen recognition receptors that recognize damage-associated molecular patterns. Interleukin (IL)-8 is a chemotactic factor produced by pathogen recognition receptor-expressing cells. A single-nucleotide polymorphism in IL8 promoter region (-251 A/T) has been implicated in inflammatory diseases. We examined whether this IL8 polymorphism confers susceptibility to AP. METHODS: Patients with AP (n = 357) were prospectively recruited...
January 2018: Pancreas
https://www.readbyqxmd.com/read/28986573/activin-in-acute-pancreatitis-potential-risk-stratifying-marker-and-novel-therapeutic-target
#12
Jonas J Staudacher, Cemal Yazici, Timothy Carroll, Jessica Bauer, Jingbo Pang, Nancy Krett, Yinglin Xia, Annette Wilson, Georgios Papachristou, Andrea Dirmeier, Claudia Kunst, David C Whitcomb, Giamila Fantuzzi, Barbara Jung
Acute Pancreatitis is a substantial health care challenge with increasing incidence. Patients who develop severe disease have considerable mortality. Currently, no reliable predictive marker to identify patients at risk for severe disease exists. Treatment is limited to rehydration and supporting care suggesting an urgent need to develop novel approaches to improve standard care. Activin is a critical modulator of inflammatory responses, but has not been assessed in pancreatitis. Here, we demonstrate that serum activin is elevated and strongly correlates with disease severity in two established murine models of acute pancreatitis induced by either cerulein or IL-12 + IL-18...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28880010/chronic-pancreatitis
#13
REVIEW
Jorg Kleeff, David C Whitcomb, Tooru Shimosegawa, Irene Esposito, Markus M Lerch, Thomas Gress, Julia Mayerle, Asbjørn Mohr Drewes, Vinciane Rebours, Fatih Akisik, J Enrique Domínguez Muñoz, John P Neoptolemos
Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the pancreas in individuals with genetic, environmental and/or other risk factors who develop persistent pathological responses to parenchymal injury or stress. Potential causes can include toxic factors (such as alcohol or smoking), metabolic abnormalities, idiopathic mechanisms, genetics, autoimmune responses and obstructive mechanisms. The pathophysiology of chronic pancreatitis is fairly complex and includes acinar cell injury, acinar stress responses, duct dysfunction, persistent or altered inflammation, and/or neuro-immune crosstalk, but these mechanisms are not completely understood...
September 7, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28839444/clinical-outcomes-of-isolated-renal-failure-compared-to-other-forms-of-organ-failure-in-patients-with-severe-acute-pancreatitis
#14
COMPARATIVE STUDY
Amir Gougol, Mohannad Dugum, Anwar Dudekula, Phil Greer, Adam Slivka, David C Whitcomb, Dhiraj Yadav, Georgios I Papachristou
AIM: To assess differences in clinical outcomes of isolated renal failure (RF) compared to other forms of organ failure (OF) in patients with severe acute pancreatitis (SAP). METHODS: Using a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ (2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded...
August 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28741615/patient-and-disease-characteristics-associated-with-the-presence-of-diabetes-mellitus-in-adults-with-chronic-pancreatitis-in-the-united-states
#15
Melena D Bellin, David C Whitcomb, Judah Abberbock, Stuart Sherman, Bimaljit S Sandhu, Timothy B Gardner, Michelle A Anderson, Michele D Lewis, Samer Alkaade, Vikesh K Singh, John Baillie, Peter A Banks, Darwin Conwell, Gregory A Cote, Nalini M Guda, Thiruvengadam Muniraj, Gong Tang, Randall E Brand, Andres Gelrud, Stephen T Amann, Christopher E Forsmark, C Mel Wilcox, Adam Slivka, Dhiraj Yadav
OBJECTIVES: Diabetes mellitus (DM) is a common complication of chronic pancreatitis (CP). Past studies for DM risk factors in CP have been limited to single centers or highly focused on a single etiology such as alcoholic or hereditary disease. We studied risk factors for DM in a large population of patients with CP of all etiologies enrolled in the North American Pancreatitis 2 studies. METHODS: Participants (1,171) with CP (n=383 with DM, n=788 without DM) were enrolled prospectively from 26 participating centers...
September 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28734722/guidelines-for-the-understanding-and-management-of-pain-in-chronic-pancreatitis
#16
REVIEW
Asbjørn M Drewes, Stefan A W Bouwense, Claudia M Campbell, Güralp O Ceyhan, Myriam Delhaye, Ihsan Ekin Demir, Pramod K Garg, Harry van Goor, Christopher Halloran, Shuiji Isaji, John P Neoptolemos, Søren S Olesen, Tonya Palermo, Pankaj Jay Pasricha, Andrea Sheel, Tooru Shimosegawa, Eva Szigethy, David C Whitcomb, Dhiraj Yadav
Abdominal pain is the foremost complication of chronic pancreatitis (CP). Pain can be related to recurrent or chronic inflammation, local complications or neurogenic mechanisms with corresponding changes in the nervous systems. Both pain intensity and the frequency of pain attacks have been shown to reduce quality of life in patients with CP. Assessment of pain follows the guidelines for other types of chronic pain, where the multidimensional nature of symptom presentation is taken into consideration. Quantitative sensory testing may be used to characterize pain, but is currently used in a research setting in advanced laboratories...
September 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28600657/validation-of-demographics-etiology-and-risk-factors-for-chronic-pancreatitis-in-the-usa-a-report-of-the-north-american-pancreas-study-naps-group
#17
Darwin L Conwell, Peter A Banks, Bimaljit S Sandhu, Stuart Sherman, Samer Al-Kaade, Timothy B Gardner, Michelle A Anderson, C Mel Wilcox, Michele D Lewis, Thiruvengadam Muniraj, Christopher E Forsmark, Gregory A Cote, Nalini M Guda, Ye Tian, Joseph Romagnuolo, Stephen R Wisniewski, Randall Brand, Andres Gelrud, Adam Slivka, David C Whitcomb, Dhiraj Yadav
BACKGROUND/OBJECTIVES: Our aim was to validate recent epidemiologic trends and describe the distribution of TIGAR-O risk factors in chronic pancreatitis (CP) patients. METHODS: The NAPS-2 Continuation and Validation (NAPS2-CV) study prospectively enrolled 521 CP patients from 13 US centers from 2008 to 2012. CP was defined by definitive changes in imaging, endoscopy, or histology. Data were analyzed after stratification by demographic factors, physician-defined etiology, participating center, and TIGAR-O risk factors...
August 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28588879/an-international-multicenter-study-of-early-intravenous-fluid-administration-and-outcome-in-acute-pancreatitis
#18
Vikesh K Singh, Timothy B Gardner, Georgios I Papachristou, Mónica Rey-Riveiro, Mahya Faghih, Efstratios Koutroumpakis, Elham Afghani, Nelly G Acevedo-Piedra, Nikhil Seth, Amitasha Sinha, Noé Quesada-Vázquez, Neftalí Moya-Hoyo, Claudia Sánchez-Marin, Juan Martínez, Félix Lluís, David C Whitcomb, Pedro Zapater, Enrique de-Madaria
AIMS: Early aggressive fluid resuscitation in acute pancreatitis is frequently recommended but its benefits remain unproven. The aim of this study was to determine the outcomes associated with early fluid volume administration in the emergency room (FVER) in patients with acute pancreatitis. METHODS: A four-center retrospective cohort study of 1010 patients with acute pancreatitis was conducted. FVER was defined as any fluid administered from the time of arrival to the emergency room to 4 h after diagnosis of acute pancreatitis, and was divided into tertiles: nonaggressive (<500 ml), moderate (500 to 1000 ml), and aggressive (>1000 ml)...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28579182/acute-pancreatitis-has-a-long-term-deleterious-effect-on-physical-health-related-quality-of-life
#19
Jorge D Machicado, Amir Gougol, Kimberly Stello, Gong Tang, Yongseok Park, Adam Slivka, David C Whitcomb, Dhiraj Yadav, Georgios I Papachristou
BACKGROUND & AIMS: It is not clear how acute pancreatitis (AP) affects health related quality of life (HRQOL). We aimed to determine the long-term independent effect of AP on physical and mental HRQOL. METHODS: We analyzed data from 91 patients (mean 52 years of age, 54% women) admitted with AP to the University of Pittsburgh Medical Center from 2011 to 2015 who responded to telephone surveys at a median of 14 months after hospital discharge (interquartile range, 12-16 months)...
September 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28440306/an-evaluation-of-factors-associated-with-pathogenic-prss1-spink1-ctfr-and-or-ctrc-genetic-variants-in-patients-with-idiopathic-pancreatitis
#20
Niloofar Y Jalaly, Robert A Moran, Farshid Fargahi, Mouen A Khashab, Ayesha Kamal, Anne Marie Lennon, Christi Walsh, Martin A Makary, David C Whitcomb, Dhiraj Yadav, Liudmila Cebotaru, Vikesh K Singh
OBJECTIVES: We evaluated factors associated with pathogenic genetic variants in patients with idiopathic pancreatitis. METHODS: Genetic testing (PRSS1, CFTR, SPINK1, and CTRC) was performed in all eligible patients with idiopathic pancreatitis between 2010 to 2015. Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)<35 years of age; and (4) family history of pancreatitis...
August 2017: American Journal of Gastroenterology
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