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https://www.readbyqxmd.com/read/29676403/combined-endoscopic-transorbital-and-endonasal-repair-of-high-flow-orbital-apex-middle-fossa-cerebrospinal-fluid-leak-with-a-nasoseptal-flap
#1
Brandon Lucke-Wold, Gustavo Mendez, David Cua, Paul Akins, Haley Gillham, Jeremy Ciporen
Background and importance: High flow orbital apex or middle fossa cerebrospinal fluid (CSF) leaks can be life threatening and complex to repair. These leaks associated with large dural defects are most commonly repaired with an open temporalis muscle patch or free flaps, but these flaps do not always stop the leak. Clinical Presentation: A 65-year-old patient presented two years after orbital exenteration and radiation for squamous cell carcinoma. He developed multi-organism meningitis and pneumocephalus secondary to a large high-flow orbital apex/middle fossa CSF leak...
2018: Journal of neuroinflammation and neurodegenerative diseases
https://www.readbyqxmd.com/read/29666610/fungi-induced-upper-and-lower-respiratory-tract-allergic-diseases-one-entity
#2
Aleksandra Barac, David S Y Ong, Ljiljana Jovancevic, Aleksandar Peric, Pavol Surda, Vesna Tomic Spiric, Salvatore Rubino
Introduction: Aspergillus can cause different allergic diseases including allergic bronchopulmonary aspergillosis (ABPA) and allergic fungal rhinosinusitis (AFRS). ABPA is allergic pulmonary disease against Aspergillus antigens. AFRS is a type of chronic rhinosinusitis (CRS) presented as hypersensitivity reactions to the fungal presence in sinuses. The aim of the present study was to clarify if ABPA and AFRS could be considered as a common disease entity. Methodology: The prospective cohort study included 75 patients with ABPA...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29660226/delays-in-lung-cancer-referral-pathways-between-rural-and-urban-patients-in-north-queensland-a-mixed-methods-study
#3
R Verma, S Pathmanathan, Z Otty, J Binder, V Vangaveti, P Buttner, S Sabesan
INTRODUCTION: Aims of this study were to examine time delays in lung cancer referral pathways in North Queensland (NQ), Australia, and explore patients' perspective of factors causing these delays. METHODS: Prospective study of patients attending three cancer centres in Townsville, Cairns and Mackay in NQ from 2009 to 2012. Times along referral pathway were divided as follows: Onset of symptoms to treatment (T1), symptoms to general practitioner(GP) (T2), GP to specialist (T3), and Specialist to treatment (T4)...
April 16, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29617493/pectoralis-major-myocutaneous-flap-in-head-and-neck-surgery-reconstructions-critical-analysis
#4
Marcelo Benedito Menezes, Kassem Samir Saleh, Marianne Yumi Nakai, Lucas Porto Maurity Dias, Norberto Kodi Kavabata, Antônio José Gonçalves
OBJECTIVE: to evaluate the results of the use of the pectoralis major flap in the reconstruction of head and neck surgeries. METHODS: we conducted a retrospective study with data bank analysis and review of medical records of patients with head and neck cancer operated at the Discipline of Head and Neck Surgery, Surgery Department, São Paulo Holy Home of Mercy, using the pectoralis major flap for reconstruction, in a period of 16 years. We analyzed age, gender, primary site of neoplasia, clinical staging, preoperative radiotherapy (RT) and complications, classified as major and minor...
March 29, 2018: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29617065/relationships-between-self-injurious-behaviors-pain-reactivity-and-%C3%AE-endorphin-in-children-and-adolescents-with-autism
#5
Sylvie Tordjman, George M Anderson, Annaëlle Charrier, Cécile Oriol, Solenn Kermarrec, Roberto Canitano, Michel Botbol, Nathalie Coulon, Corinne Antoine, Sylvie Brailly-Tabard, David Cohen, Hazar Haidar, Séverine Trabado, Michèle Carlier, Guillaume Bronsard, Laurent Mottron
OBJECTIVE: Autism and certain associated behaviors including self-injurious behaviors (SIB) and atypical pain reactivity have been hypothesized to result from excessive opioid activity. The objective of this study was to examine the relationships between SIB, pain reactivity, and β-endorphin levels in autism. METHODS: Study participants were recruited between 2007 and 2012 from day care centers and included 74 children and adolescents diagnosed with autism (according to DSM-IV-TR, ICD-10, and CFTMEA) and intellectual disability...
March 13, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29603568/community-activities-predict-disability-and-mortality-in-community-dwelling-older-adults
#6
Mika Okura, Mihoko Ogita, Miki Yamamoto, Toshimi Nakai, Tomoko Numata, Hidenori Arai
AIM: With aging, it is important to maintain older community dwellers' regular engagement with familiar community activities (CA) engaged in close to home to protect them from frailty. Thus, the present study aimed to examine whether CA items or CA score were associated with mortality or the need for care under the new long-term care insurance service requirements over 3 years among community-dwelling older Japanese adults. METHODS: We analyzed cohort data for older adults from a prospective cohort study in Kami town, Japan...
March 30, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29601672/mri-guided-interventional-natural-killer-cell-delivery-for-liver-tumor-treatment
#7
Zhanliang Su, Xifu Wang, Linfeng Zheng, Tianchu Lyu, Matteo Figini, Bin Wang, Daniel Procissi, Junjie Shangguan, Chong Sun, Liang Pan, Lei Qin, Bin Zhang, Yury Velichko, Riad Salem, Vahid Yaghmai, Andrew C Larson, Zhuoli Zhang
While natural killer (NK) cell-based adoptive transfer immunotherapy (ATI) provides only modest clinical success in cancer patients. This study was hypothesized that MRI-guided transcatheter intra-hepatic arterial (IHA) infusion permits local delivery to liver tumors to improve outcomes during NK-based ATI in a rat model of hepatocellular carcinoma (HCC). Mouse NK cells were labeled with clinically applicable iron nanocomplexes. Twenty rat HCC models were assigned to three groups: transcatheter IHA saline infusion as the control group, transcatheter IHA NK infusion group, and intravenous (IV) NK infusion group...
March 30, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29595367/lessons-learned-from-the-implementation-of-a-medically-enhanced-residential-treatment-mert-model-integrating-intravenous-antibiotics-and-residential-addiction-treatment
#8
Honora Englander, Talitha Wilson, Devin Collins, Elena Phoutrides, Melissa Weimer, P Todd Korthuis, Jessica Calcagni, Christina Nicolaidis
BACKGROUND: Hospitalizations for severe infections associated with substance use disorder (SUD) are increasing. People with SUD often remain hospitalized for many weeks instead of completing intravenous antibiotics at home; often, they are denied skilled nursing facility admission. Residential SUD treatment facilities are not equipped to administer intravenous antibiotics. We developed a medically enhanced residential treatment (MERT) model integrating residential SUD treatment and long-term IV antibiotics as part of a broader hospital-based addiction medicine service...
March 29, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29573167/the-effects-of-transcranial-pulsed-electromagnetic-field-stimulation-on-quality-of-life-in-parkinson-s-disease
#9
Bo Mohr Morberg, Anne Sofie Malling, Bente Rona Jensen, Ole Gredal, Per Bech, Lene Wermuth
BACKGROUND: Pulsed electromagnetic fields induce a protective and anti-inflammatory effect in the nervous system primarily due to growth factor up regulation that possibly abates neurodegeneration in Parkinson's disease. This study investigated treatment effects of transcranial pulsed electromagnetic fields on quality of life in Parkinson's disease and secondly the feasibility and safety of this treatment. METHODS: In this double-blinded clinical study, 97 participants with idiopathic Parkinson's disease (Hoehn & Yahr I-IV) in optimal medical anti-parkinson treatment, were block randomized 3:3 to either active (n=49) or placebo treatment (n=48)...
March 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29571602/heart-failure-after-the-norwood-procedure-an-analysis-of-the-single-ventricle-reconstruction-trial
#10
William T Mahle, Chenwei Hu, Felicia Trachtenberg, JonDavid Menteer, Steven J Kindel, Anne I Dipchand, Marc E Richmond, Kevin P Daly, Heather T Henderson, Kimberly Y Lin, Michael McCulloch, Ashwin K Lal, Kurt R Schumacher, Jeffrey P Jacobs, Andrew M Atz, Chet R Villa, Kristin M Burns, Jane W Newburger
BACKGROUND: Heart failure results in significant morbidity and mortality in young children with hypoplastic left heart syndrome (HLHS) after the Norwood procedure. METHODS: We studied subjects enrolled in the prospective Single Ventricle Reconstruction (SVR) Trial who survived to hospital discharge after a Norwood operation and were followed up to age 6 years. The primary outcome was heart failure, defined as heart transplant listing after Norwood hospitalization, death attributable to heart failure, or symptomatic heart failure (New York Heart Association [NYHA] Class IV)...
February 16, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29564377/is-a-shortened-length-of-stay-and-increased-rate-of-discharge-to-home-associated-with-a-low-readmission-rate-and-cost-effectiveness-after-primary-total-knee-arthroplasty
#11
Steven J Barad, Stephen M Howell, Joyce Tom
Background: It is controversial whether shortening the average length of hospital stay and increasing discharge from a rehabilitation facility to home with either health care or outpatient physical therapy is safe and cost-effective. Methods: We computed the average length of hospital stay; the rate of discharge to a rehabilitation facility, home with health care, or home with outpatient physical therapy; the all-cause readmission rate within 30 days of discharge per year; and cost savings for 2328 consecutive patients treated with a unilateral primary total knee replacement between 2009 and 2014...
March 2018: Arthroplasty Today
https://www.readbyqxmd.com/read/29557669/telemonitoring-in-copd-the-chromed-study-a-randomized-clinical-trial
#12
Paul P Walker, Pasquale P Pompilio, Paolo Zanaboni, Trine S Bergmo, Kaiu Prikk, Andrei Malinovschi, Josep M Montserrat, Jo Middlemass, Silvana Šonc, Giulia Munaro, Dorjan Marušič, Ruth Sepper, Roberto Rosso, A Niroshan Siriwardena, Christer Janson, Ramon Farre, Peter M A Calverley, Raffaele L Dellaca'
RATIONALE: Early detection of COPD exacerbations using tele-monitoring of physiological variables might reduce the frequency of hospitalisation. OBJECTIVES: To evaluate the efficacy of home monitoring of lung mechanics by the forced oscillation technique (FOT) and cardiac parameters in older COPD patients with co-morbidities. METHODS: This multicentre, randomized clinical trial recruited 312 GOLD grade II-IV COPD patients (median age 71 years [IQR:66-76], 49...
March 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29556215/clinical-and-physiological-characterization-of-elevated-plasma-glucagon-like-peptide-1-levels-hyperglipemia-in-a-dipeptidyl-peptidase-iv-mutation-carrier
#13
Dandan Zhao, Shaoqian Zhao, Xiao Wang, Mingbo Su, Wen Liu, Qinyun Ma, Jie Hong, Weiqiong Gu, Jingya Li, Ruixin Liu, Guang Ning, Jiqiu Wang, Yifei Zhang
The clinical application of dipeptidyl peptidase IV inhibitors (DPP4i) increasing active glucagon-like peptide-1 (AGLP-1) levels has been linked to pancreatitis, pancreatic tumors, and cardiovascular events. However, DPP4 mutations in humans or the long-term outcomes of high glucagon-like peptide-1 (GLP-1) level exposure have not been reported. A trio family with a proband showing an extremely high AGLP-1 level [defined here as hyperglipemia (hyper-glucagon-like peptide-1-emia)] were conducted whole-exome sequencing for potential pathogenic genetic defects...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29548042/maternal-fetal-medicine-workforce-survey-are-we-ready-for-regionalized-levels-of-maternal-care
#14
Katharine D Wenstrom, Mary E D'Alton, Daniel F O'Keefe
OBJECTIVE:  To conduct a survey of the members of the Society for Maternal-Fetal Medicine (SMFM) to determine the practice patterns of maternal-fetal medicine (MFM) subspecialists in the United States and to estimate the likelihood that our work force is sufficient to support the proposed MFM staffing requirements for level III and IV maternity centers. STUDY DESIGN:  All regular SMFM members in the United States were invited to answer a 26 question survey by email...
March 16, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29540910/guidelines-for-psychosocial-interventions-in-addictive-disorders-in-india-an-introduction-and-overview
#15
EDITORIAL
Pratima Murthy
While guidelines for psychosocial interventions in addictive disorders in India were earlier rooted in clinical experience and global empirical evidence, recently there have been efforts to develop guidelines for intervention based on the local needs assessments of specific populations and more appreciably, a testing of the effectiveness of the interventions. This supplement on psychosocial interventions for addictive disorders covers some of the important aspects of psychosocial interventions in five sections...
February 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29531048/the-great-recession-worsened-blood-pressure-and-blood-glucose-levels-in-american-adults
#16
Teresa Seeman, Duncan Thomas, Sharon Stein Merkin, Kari Moore, Karol Watson, Arun Karlamangla
Longitudinal, individual-specific data from the Multi-Ethnic Study of Atherosclerosis (MESA) provide support for the hypothesis that the 2008 to 2010 Great Recession (GR) negatively impacted the health of US adults. Results further advance understanding of the relationship by ( i ) illuminating hypothesized greater negative impacts in population subgroups exposed to more severe impacts of the GR and ( ii ) explicitly controlling for confounding by individual differences in age-related changes in health over time...
March 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29522293/ureteroscopy-and-stone-treatment-in-the-elderly-%C3%A2-70-years-prospective-outcomes-over-5-years-with-a-review-of-literature
#17
Sarah Prattley, James Voss, Stephanie Cheung, Robert Geraghty, Patrick Jones, Bhaskar K Somani
OBJECTIVE: To assess outcomes of ureteroscopy for treatment of stone disease in the elderly. Ureteroscopy (URS) is an increasingly popular treatment modality for urolithiasis and its applications are ever expanding with the development of newer technologies. Its feasibility and outcomes within the elderly population to our knowledge remain under-reported. MATERIALS AND METHODS: We examined the patient demographics and surgical outcomes from our prospective database for patients ≥70 years who underwent URS for urolithiasis, in a 5-year period between March 2012 and December 2016...
March 9, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29520946/links-between-the-organization-of-the-family-home-environment-and-child-obesity-a-systematic-review
#18
REVIEW
C R Bates, J Buscemi, L M Nicholson, M Cory, A Jagpal, A M Bohnert
Due to increasingly high rates of child overweight and obesity, it is important to identify risk and protective factors that may inform more effective prevention and intervention. The degree of organization in the family home environment is a studied, but not well-specified, factor that may impact child weight. Prior research on household organization has examined an array of constructs, including family routines, limit setting, household chaos, crowding and the broad home environment. This study systematically reviews literature on organization within the family home environment and weight among children ages 2-12...
March 8, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29514362/impact-of-intravenous-acetaminophen-on-lengths-of-stay-and-discharge-status-after-total-knee-arthroplasty
#19
John W Barrington, Ryan N Hansen, Belinda Lovelace, Elaine A Böing, Morad Chughtai, Jared M Newman, An T Pham, Anton Khlopas, Nipun Sodhi, Assem A Sultan, Michael A Mont
Postoperative pain remains difficult to control after total knee arthroplasty (TKA). While various modalities have been used, they have been associated with several side effects. For example, opioids have many side effects including: sedation, dizziness, nausea, vomiting, constipation, respiratory depression, and can lead to dependency. Recently, intravenous (IV) acetaminophen has been introduced as a method to manage postoperative pain. Therefore, the purpose of this study was to compare the postoperative outcomes of TKA patients who received oral acetaminophen versus IV acetaminophen...
March 7, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29509215/predictors-of-repeat-emergency-department-visits-among-patients-aged-over-65-years
#20
Hanen Ghazali, Rania Jebri, Anware Yahmadi, Najla El Heni, Ines Chermiti, Sami Souissi
BACKGROUND: The objective of our study was to evaluate the predictors of repeat visits at Emergency Department (ED) in patients aged ≥ 65 years. METHODS: A prospective observational study was conducted over a month. Inclusion:  patients (age> = 65 year) seen in the ED and leaving the same day. The epidemiological and clinical characteristics at the first visit (index visit (IV)) were collected. The Identification of Senior At Risk (ISAR) score was used to assess our patients...
May 2017: La Tunisie Médicale
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