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preoperative hematological evaluation

Katherine D Culbreath, Alejandro V Garcia, Ira L Leeds, Mitchell R Ladd, Todd Crawford, Emily Boss, Daniel S Rhee
INTRODUCTION: Complete tumor resection of primary malignant liver tumors offers the best chance of survival. However, many of these children may experience anemia and failure to thrive. This study analyzes the association of preoperative anemia and nutritional support with outcomes in children undergoing major resection of primary malignant liver tumors. METHODS: Using the National Surgical Quality Improvement Program Pediatric database from 2012 to 2015, children undergoing major liver resections for primary malignant hepatic tumors were selected...
December 2018: Journal of Surgical Research
Andrea Angelini, Giulia Trovarelli, Antonio Berizzi, Elisa Pala, Anna Breda, Marco Maraldi, Pietro Ruggieri
BACKGROUND: Metastatic lesions to the proximal femur occur frequently and require special consideration due to the high risk of pathologic fractures. Type of surgery might influence patient survival considering the growing concept of oligometastases. In fact, the use of modular tumor megaprosthesis is increasing in the last decades compared to intramedullary nailing. Aim of this study was to evaluate oncological and functional results of treatment in patients with pathologic or impending fracture of the proximal femur, with patient survival being the primary, complications the secondary, and functional results the tertiary endpoint...
November 2018: Injury
Brandon A Sherrod, Samuel G McClugage, Vincent E Mortellaro, Inmaculada B Aban, Brandon G Rocque
PURPOSE: To evaluate venous thromboembolism (VTE) rates and risk factors following inpatient pediatric surgery. METHODS: 153,220 inpatient pediatric surgical patients were selected from the 2012-2015 NSQIP-P database. Demographic and perioperative variables were documented. Primary outcome was VTE requiring treatment within 30 postoperative days. Secondary outcomes included length of stay (LOS) and 30-day mortality. Prediction models were generated using logistic regression...
October 10, 2018: Journal of Pediatric Surgery
Carmine Noviello, Alfonso Papparella, Mercedes Romano, Giovanni Cobellis
Background: Pediatric cholelithiasis unrelated to hematological disorders is an increasing disease. We analyzed our experience in the surgical treatment of these cases to evaluate risk factors, clinical presentation, intervention and follow-up. Methods: From January 2010 to December 2016, we retrospectively recorded all data (hematological study, familiarity, use of lithogenic drugs and parenteral nutrition) of cholecystectomies for cholelithiasis not related to hematological diseases...
October 2018: Gastroenterology Research
Kei Kimura, Tomoki Yamano, Masataka Igeta, Ayako Imada, Song Jihyung, Akihito Babaya, Michiko Hamanaka, Masayoshi Kobayashi, Kiyoshi Tsukamoto, Masafumi Noda, Masataka Ikeda, Naohiro Tomita
The purpose of the present study was to assess the efficacy and toxicity of preoperative chemoradiotherapy using irinotecan against locally advanced lower rectal cancer according to UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphisms. Between 2009 and 2016, 46 patients with resectable rectal cancer (T3-T4, N0-N2, M0) received preoperative chemoradiotherapy consisting of 80 mg/m2 per day tegafur/gimeracil/oteracil (S-1; days 1-5, 8-12, 22-26, and 29-33), 60 mg/m2 per day irinotecan (days 1, 8, 22, and 29), and 45 Gy radiation (1...
September 23, 2018: Cancer Science
Weiheng Wen, Peili Wu, Jitong Li, He Wang, Jia Sun, Hong Chen
BACKGROUND: The American Joint Committee on Cancer has recently revised the tumor-node-metastasis (TNM) staging system on thyroid cancer, which illustrated that the cut-off age for predicting mortality has elevated from 45 to 55 years old. We aimed to investigate the inflammation index based on hematological parameters to predict the clinical characteristics of elderly papillary thyroid cancer (PTC) patients with an inferior prognosis. METHODS: We retrospectively analyzed 558 patients newly diagnosed with PTC from January 2013 to December 2017, and 82 out of the 558 patients were over 55 years old...
September 21, 2018: Journal of Translational Medicine
Guanglei Zhao, Jin Wang, Jun Xia, Yibing Wei, Siqun Wang, Gangyong Huang, Feiyan Chen, Jie Chen, Jingsheng Shi, Yuanqing Yang
BACKGROUND: To explore and evaluate the predictive value of preoperative Neutrophil-lymphocyte ratio (NLR) on the recurrence of pigmented villonodular synovitis (PVNS) of the knee joint treated by arthroscopic surgery combining local radiotherapy. METHODS: Sixty pathological-proven PVNS cases of the knee joint in our department from April 2006 to March 2017 were included. All of them are treated by arthroscopic synovectomy combined with adjuvant radiotherapy. The pre-operative hematological indexes such as c-reactive protein (CRP), erythrocyte sedimentation rate (ESR), NLR, Platelet-lymphocyte ratio (PLR) and Lymphocyte-monocyte ratio (LMR) were collected retrospectively and their relationship with postoperative recurrence was analyzed by using univariate and multivariate analysis, the receiver operating characteristic curves (ROC curve), the Kappa correspondence test and the Mc Nemar Chi-square test...
September 19, 2018: BMC Musculoskeletal Disorders
Kaan Gokcen, Gokce Dundar, Halil Gulbahar, Gokhan Gokce, Emin Yener Gultekin
Background: The purpose of this study was to assess the diagnostic role of preoperative hematological parameters, especially neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in germ cell testicular malignancies and their prediagnostic role in staging of testicular cancer. Materials and Methods: In this cross-sectional retrospective study, we analyzed 39 patients who underwent radical orchiectomy due to a testicular cancer (Group 1) and 82 patients on whom varicocelectomy procedure was performed as control group (Group 2) between January 2006 and January 2016 in our clinic...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Xingchen Cai, Weisong Shen, Zhen Guo, Yi Li, Lei Cao, Jianfeng Gong, Weiming Zhu
Background: Incisional surgical site infection (iSSI) is a frequent postoperative complication of abdominal surgeries in patients with Crohn's disease (CD). In this study, we investigated the association between thickness of subcutaneous fat (TSF) and iSSI in patients with CD undergoing intestinal resections. Patients and Methods: Patients with CD who had undergone abdominal surgery from January 2014 to January 2017 were included in this retrospective study. Patients' TSF and other possible predictors of iSSI, including clinical characteristics, preoperative medications, hematological index, surgery-related data, and postoperative outcomes, were collected...
2018: Gastroenterology Research and Practice
Hidenori Takahashi, Hirofumi Akita, Tatsuya Ioka, Hiroshi Wada, Akira Tomokoni, Kei Asukai, Masayuki Ohue, Masahiko Yano, Osamu Ishikawa
OBJECTIVES: The objectives of this study were to assess the feasibility of preoperative gemcitabine/nab-paclitaxel-based chemoradiation therapy (CRT) for patients with borderline resectable pancreatic cancer (BRPC), which consists of induction chemotherapy and subsequent CRT, and to determine the recommended dose (RD) of gemcitabine/nab-paclitaxel with concurrent radiation therapy in a phase I trial. METHODS: Patients with BRPC received gemcitabine (1000 mg/m)/nab-paclitaxel (125 mg/m) on days 1, 8, and 15 during each 4-week cycle, which was repeated for 2 cycles as induction chemotherapy...
October 2018: Pancreas
Joo-Hyuk Son, Joo-Hyung Lee, Jung-Ah Jung, Tae-Wook Kong, Jiheum Paek, Suk-Joon Chang, Hee-Sug Ryu
OBJECTIVES: The aim of this study was to analyze risk factors for septic complications during adjuvant chemotherapy and their impact on survival in patients with advanced epithelial ovarian cancer treated with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). METHODS: We retrospectively reviewed the medical records of 69 patients with advanced epithelial ovarian cancer from 2004 to 2017. All patients underwent three cycles of NACT followed by IDS and adjuvant chemotherapy...
October 2018: Gynecologic Oncology
Yifeng Bao, Minfeng Yang, Chunjing Jin, Shiqiang Hou, Beitian Shi, Jinlong Shi, Ning Lin
OBJECTIVE: Hematologic inflammatory markers are simple, inexpensive prognostic markers for various conditions. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and red blood cell distribution width (RDW) has been shown in a variety of tumors. We evaluated the prognostic value of these markers in glioma. METHODS: We performed a retrospective medical record review of 219 patients with glioma from January 2012 to January 2017, evaluating the effect of NLR, PLR, MLR, and RDW on prognosis...
November 2018: World Neurosurgery
Xin Hua Yin, Bao Rong He, Zhong Kai Liu, Ding Jun Hao
Literature on the treatment of cervical spinal tuberculosis (CSTB) is uncommon, the surgical approaches to cervical spinal tuberculosis were controversial. The aim of the study was to evaluate the clinical outcomes of 3 surgical techniques in CSTB patients, and to determine the most appropriate approach for CSTB patients. Between April 2006 and June 2012, we performed a retrospective review of clinical and radiographic data that were collected from 850 consecutive spinal tubercular patients, including 87 patients who were diagnosed and treated for CSTB in our hospital...
July 2018: Medicine (Baltimore)
L A Nikolenko, E S Shopova, E S Golovneva, E S Nikolenko
Due to current options of cardiac surgery, operations on the heart of elderly patients have become routine in specialized cardiosurgical centers. The issue of pre- and postoperative anemia of different nature is essential in surgical correction of heart valves and coronary bypass. AIM: To study indexes of red blood in elderly patients with ischemic heart disease (IHD) and pathology of heart valves before and after surgical correction, including the relationship with position and type of the prosthesis...
2018: Kardiologiia
Patrick T Hangge, William W Sheaffer, Matthew Neville, Nabil Wasif, Richard J Gray, Barbara A Pockaj, Chee-Chee H Stucky
BACKGROUND: The purpose of this study was to describe the diagnostic value and therapeutic benefit of diagnostic splenectomy. METHODS: Retrospective review was performed of patients undergoing splenectomy with an unknown diagnosis (UD), a hematologic malignancy (HM) or idiopathic thrombocytopenic purpura. Surgical indications and postoperative outcomes were evaluated. RESULTS: 113 splenectomy patients were identified. Of the UD patients undergoing splenectomy, 46% (n = 16) received a definitive diagnosis postoperatively...
May 29, 2018: American Journal of Surgery
Janet E Murphy, Jennifer Y Wo, David P Ryan, Wenqing Jiang, Beow Y Yeap, Lorraine C Drapek, Lawrence S Blaszkowsky, Eunice L Kwak, Jill N Allen, Jeffrey W Clark, Jason E Faris, Andrew X Zhu, Lipika Goyal, Keith D Lillemoe, Thomas F DeLaney, Carlos Fernández-Del Castillo, Cristina R Ferrone, Theodore S Hong
Importance: Patients with borderline-resectable pancreatic ductal adenocarcinoma have historically poor outcomes with surgery followed by adjuvant chemotherapy. Evaluation of a total neoadjuvant approach with highly active therapy is warranted. Objective: To evaluate the margin-negative (R0) resection rate in borderline-resectable pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX (fluorouracil, irinotecan, and oxaliplatin) therapy and individualized chemoradiotherapy...
July 1, 2018: JAMA Oncology
Delia Franchini, Carmela Valastro, Stefano Ciccarelli, Francesco Caprio, Diana Lenoci, Antonio Di Bello
Loggerhead sea turtles ( Caretta caretta) are among the most frequent victims of bycatch in drifting longlines, and the ingestion of fish hooks and fishing lines is one of the most frequent causes of death of sea turtles. The aim of this study was to evaluate whether coelomic ultrasound (US) can be decisive, not only for diagnosis but also to optimize surgical planning based on preoperative evaluation of the bowel conditions and, in addition, to see if there are characteristic sonographic findings in sea turtles associated with the ingestion of fishing lines...
October 2018: Journal of Wildlife Diseases
Hande Köksal, Derviş Ateş, Emet Ebru Nazik, İlknur Küçükosmanoğlu, Serap Melek Doğan, Osman Doğru
BACKGROUND: The aim of this study was to evaluate the relationship between preoperative hematological inflammatory markers of the patients who underwent a surgery for incarcerated hernia and intestinal resection requirement. METHODS: The data of 102 patients who underwent a surgery for incarcerated hernia were retrospectively evaluated. Whole blood cell counts were preoperatively measured, and operation types and pathology results were recorded. The patients with intestinal resections were compared with those without any resection in terms of leukocyte number, neutrophil rate, red cell distribution width (RDW), platelet distribution width, neutrophil-to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV)...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Mitra Modares Gilani, Zohreh Kazemi, Narges Zamani, Hadis Shahrami, Akram Ghahghaei-Nezamabadi, Soureh Sheikham
Background: Recently preoperative hematologic parameters have attracted attention for their capacity to predict tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the tumor microenvironment, we evaluated the role of the preoperative monocyte count as a surrogate for TAM. Methods: We retrospectively reviewed 166 patients with histopathologically proven endometrial cancers from January 2011 to March 2015 and assessed any association of preoperative monocyte count with tumor characteristics and recurrence...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Ji-Hyun Kim, You-Jin Bae, Kyong-Hwa Jun, Hyung-Min Chin
BACKGROUND: This study explored the cumulative incidence of anemia after gastrectomy in patients with early-stage gastric cancer and evaluated the relationship between postgastrectomy anemia and nutritional factors during long-term follow-up. METHODS: The medical records of patients with stage I gastric cancer who underwent curative gastrectomy between January 2006 and December 2013 were reviewed retrospectively. Hematologic parameters like hemoglobin, iron, ferritin, and vitamin B12 level were obtained prior to and after surgery with other nutritional parameters such as total protein, albumin, total cholesterol, triglyceride, calcium, and phosphate...
April 2018: International Journal of Surgery
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