keyword
https://read.qxmd.com/read/38429546/graded-exercise-therapy-compared-to-activity-management-for-paediatric-chronic-fatigue-syndrome-myalgic-encephalomyelitis-pragmatic-randomized-controlled-trial
#1
JOURNAL ARTICLE
Daisy M Gaunt, Amberly Brigden, Shaun R S Harris, William Hollingworth, Russell Jago, Emma Solomon-Moore, Lucy Beasant, Nicola Mills, Parisa Sinai, Esther Crawley, Chris Metcalfe
The MAGENTA pragmatic parallel groups randomized controlled trial compared graded exercise therapy (GET) with activity management (AM) in treating paediatric myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). Children aged 8-17 years with mild/moderate ME/CFS and presenting to NHS specialist paediatric services were allocated at random to either individualised flexible treatment focussing on physical activity (GET, 123 participants) or on managing cognitive, school and social activity (AM, 118 participants) delivered by NHS therapists...
March 2, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/37833734/reconsolidation-of-traumatic-memories-protocol-compared-to-trauma-focussed-cognitive-behaviour-therapy-for-post-traumatic-stress-disorder-in-uk-military-veterans-a-randomised-controlled-feasibility-trial
#2
JOURNAL ARTICLE
J Sturt, R Rogers, C Armour, D Cameron, L De Rijk, F Fiorentino, T Forbes, C Glen, A Grealish, J Kreft, I Meye de Souza, E Spikol, V Tzouvara, N Greenberg
BACKGROUND: Post-traumatic stress disorder (PTSD) occurs more commonly in military veterans than the general population. Whilst current therapies are effective, up to half of veterans commencing treatment do not complete it. Reconsolidation of Traumatic Memories (RTM) protocol is a novel, easy to train, talking therapy with promising findings. We examine the feasibility of undertaking an efficacy trial of RTM in veterans. METHODS: A parallel group, single-centre randomised controlled feasibility trial with a post-completion qualitative interview study...
October 13, 2023: Pilot and Feasibility Studies
https://read.qxmd.com/read/37785064/the-effect-of-three-different-positioning-approaches-for-prone-rectum-radiotherapy-on-positioning-accuracy-and-treatment-margins
#3
JOURNAL ARTICLE
X Chen, A Chen, L Liu, W Cai, J Zhu, X Jiang
PURPOSE/OBJECTIVE(S): The positioning accuracy of rectal radiotherapy patients was greatly affected by the immobilization gadget, breathing motion, bladder volume etc. Prone is one of the common treatment positions for rectum radiotherapy patients as it can displace the small bowels to reduce side effects. Our team would like to further enhance positioning accuracy by evaluating different positioning approaches. MATERIALS/METHODS: A total of 16 patients from each group were selected retrospectively...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37568130/prehabilitation-in-the-lung-cancer-pathway-a-scoping-review
#4
REVIEW
Kelly Wade-Mcbane, Alex King, Catherine Urch, Julian Jeyasingh-Jacob, Andrew Milne, Clair Le Boutillier
BACKGROUND: Lung cancer is the third most common type of cancer in the UK. Treatment outcomes are poor and UK deaths from lung cancer are higher than any other cancer. Prehabilitation has shown to be an important means of preparing patients both physically and psychologically for cancer treatment. However, little is understood about the context and mechanisms of prehabilitation that can impact physiological and psychological wellbeing. Our aim was to review and summarise primary research on prehabilitation in the lung cancer pathway using a realist approach...
August 11, 2023: BMC Cancer
https://read.qxmd.com/read/37430234/reducing-sickness-absence-and-stigma-due-to-mental-health-difficulties-a-randomised-control-treatment-trial-rct-of-a-low-intensity-psychological-intervention-and-stigma-reduction-programme-for-common-mental-disorder-prevail
#5
JOURNAL ARTICLE
Nicola S Gray, Helen Davies, Rhodri Brad, Robert J Snowden
BACKGROUND: Common mental disorders are the leading cause of workplace absences. The Prevail intervention programme aims to reduce stigma and to educate staff and managers about evidence-based low intensity psychological interventions for common mental disorders (depression, anxiety, stress, and distress). Prevail is innovative in taking a public health approach. It is designed to be given to all employees irrespective of their past or current mental health. Prevail was evaluated in three studies examining: (1) the acceptability of the intervention and perceived usefulness; (2) whether the intervention altered stigmatic attitudes and motivation to seek help; and (3) whether the intervention reduced sickness absence, both overall and due to mental health problems...
July 10, 2023: BMC Public Health
https://read.qxmd.com/read/36691120/evaluating-the-effect-of-short-course-rifapentine-based-regimens-with-or-without-enhanced-behaviour-targeted-treatment-support-on-adherence-and-completion-of-treatment-for-latent-tuberculosis-infection-among-adults-in-the-uk-rid-tb-treat-protocol-for-an-open
#6
JOURNAL ARTICLE
Molebogeng X Rangaka, Yohhei Hamada, Trinh Duong, Henry Bern, Joanna Calvert, Marie Francis, Amy Louise Clarke, Alex Ghanouni, Charlotte Layton, Vanessa Hack, Ellen Owen-Powell, Julian Surey, Karen Sanders, Helen L Booth, Angela Crook, Chris Griffiths, Robert Horne, Heinke Kunst, Marc Lipman, Mike Mandelbaum, Peter J White, Dominik Zenner, Ibrahim Abubakar
INTRODUCTION: The successful scale-up of a latent tuberculosis (TB) infection testing and treatment programme is essential to achieve TB elimination. However, poor adherence compromises its therapeutic effectiveness. Novel rifapentine-based regimens and treatment support based on behavioural science theory may improve treatment adherence and completion. METHODS AND ANALYSIS: A pragmatic multicentre, open-label, randomised controlled trial assessing the effect of novel short-course rifapentine-based regimens for TB prevention and additional theory-based treatment support on treatment adherence against standard-of-care...
September 6, 2022: BMJ Open
https://read.qxmd.com/read/36438018/snakebite-knowledge-assessment-and-training-of-healthcare-professionals-in-asia-africa-and-the-middle-east-a-review
#7
JOURNAL ARTICLE
Godpower Chinedu Michael, Auwal Adam Bala, Mustapha Mohammed
Snakebite envenoming (SBE) is a common neglected tropical disease in rural communities of Asia, Africa and Latin America. Among the several challenges besetting the control of SBE is inadequate access to high-quality care by snakebite victims, partly contributed by inadequate knowledge of SBE among healthcare professionals (HCPs). This narrative review examined the existing literature on the knowledge of snakebites among HCPs, the factors associated with their knowledge of snakebites and their training needs...
December 2022: Toxicon: X
https://read.qxmd.com/read/36415737/post-operative-antibiotics-for-cutaneous-abscess-after-incision-and-drainage-variations-in-clinical-practice
#8
JOURNAL ARTICLE
Michael El Boghdady, Béatrice Marianne Ewalds-Kvist, Sarah Zhao, Ahmad Najdawi, Aggelos Laliotis
BACKGROUND: Acute cutaneous abscess is a common surgical condition that mostly requires incision and drainage. Despite this, there is no standardized national or international guidance on post-operative antibiotics prescription. Traditionally, antibiotics are not indicated unless complications and/or risk factors such as immunocompromisation, diabetes or cellulitis exist. We aimed to study the local practice for post-operative antibiotics prescription for cutaneous abscesses in a UK university teaching hospital...
2022: Access microbiology
https://read.qxmd.com/read/35997079/trueness-of-intraoral-scanning-of-edentulous-arches-a-comparative-clinical-study
#9
JOURNAL ARTICLE
Khaled Q Al Hamad, Fatma T Al-Kaff
PURPOSE: To compare the accuracy of intraoral scanning (IOS) of the edentulous arch with the hybrid protocol of cast digitization (CD), and to investigate the effect of arch type and area on trueness. MATERIALS AND METHODS: Participants that were edentulous in both arches were recruited. Two impression protocols were used; the IOS as the test protocol with an IOS device (TRIOS 4; 3Shape, Denmark), and the CD as the control, including tracing compound (TRACING STICKS; Kemdent, UK) for border molding, polyvinyl siloxane (Hydrorise Monophase; Zhermack, Italy) for impression, and cast digitization with a laboratory scanner (ceramill® map400, AMANNGIRRBACH, Germany)...
August 23, 2022: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://read.qxmd.com/read/35799298/the-structured-health-intervention-for-truckers-shift-cluster-randomised-controlled-trial-a-mixed-methods-process-evaluation
#10
RANDOMIZED CONTROLLED TRIAL
Amber J Guest, Nicola J Paine, Yu-Ling Chen, Anna Chalkley, Fehmidah Munir, Charlotte L Edwardson, Laura J Gray, Vicki Johnson, Katharina Ruettger, Mohsen Sayyah, Aron Sherry, Jacqui Troughton, Veronica Varela-Mato, Thomas Yates, James King, Stacy A Clemes
BACKGROUND: This paper presents the mixed methods process evaluation of the randomised controlled trial (RCT) of the Structured Health Intervention For Truckers (SHIFT), a multi-component intervention targeting physical activity and positive lifestyle behaviours in a cohort of 382 truck drivers in the UK. The SHIFT RCT found a significant difference in daily steps between intervention and control groups at 6-months in favour of the intervention participants. METHODS: SHIFT was evaluated within a cluster-RCT and involved 25 transport sites (12 intervention and 13 control sites)...
July 7, 2022: International Journal of Behavioral Nutrition and Physical Activity
https://read.qxmd.com/read/34372803/protocol-for-the-weight-bearing-in-ankle-fractures-wax-trial-a-multicentre-prospective-non-inferiority-trial-of-early-versus-delayed-weight-bearing-after-operatively-managed-ankle-fracture
#11
JOURNAL ARTICLE
C P Bretherton, H A Claireaux, J Achten, A Athwal, S J Dutton, N Peckham, S Petrou, R S Kearney, D Appelbe, X L Griffin
BACKGROUND: Unstable ankle fractures represent a substantial burden of disease, accounting for a mean hospital stay of nine days, a mean cost of £4,491 per patient and 20,000 operations per year. There is variation in UK practice around weight-bearing instructions after operatively managed ankle fracture. Early weight-bearing may reduce reliance on health services, time off work, and improve functional outcomes. However, concerns remain about the potential for complications such as implant failure...
August 9, 2021: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/34153264/safety-and-immunogenicity-of-the-chadox1-ncov-19-azd1222-vaccine-against-sars-cov-2-in-hiv-infection-a-single-arm-substudy-of-a-phase-2-3-clinical-trial
#12
MULTICENTER STUDY
John Frater, Katie J Ewer, Ane Ogbe, Mathew Pace, Sandra Adele, Emily Adland, Jasmini Alagaratnam, Parvinder K Aley, Mohammad Ali, M Azim Ansari, Anna Bara, Mustapha Bittaye, Samantha Broadhead, Anthony Brown, Helen Brown, Federica Cappuccini, Enya Cooney, Wanwisa Dejnirattisai, Christina Dold, Cassandra Fairhead, Henry Fok, Pedro M Folegatti, Jamie Fowler, Charlotte Gibbs, Anna L Goodman, Daniel Jenkin, Mathew Jones, Rebecca Makinson, Natalie G Marchevsky, Yama F Mujadidi, Hanna Nguyen, Lucia Parolini, Claire Petersen, Emma Plested, Katrina M Pollock, Maheshi N Ramasamy, Sarah Rhead, Hannah Robinson, Nicola Robinson, Patpong Rongkard, Fiona Ryan, Sonia Serrano, Timothy Tipoe, Merryn Voysey, Anele Waters, Panagiota Zacharopoulou, Eleanor Barnes, Susanna Dunachie, Philip Goulder, Paul Klenerman, Gavin R Screaton, Alan Winston, Adrian V S Hill, Sarah C Gilbert, Andrew J Pollard, Sarah Fidler, Julie Fox, Teresa Lambe
BACKGROUND: Data on vaccine immunogenicity against SARS-CoV-2 are needed for the 40 million people globally living with HIV who might have less functional immunity and more associated comorbidities than the general population. We aimed to explore safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in people with HIV. METHODS: In this single-arm open-label vaccination substudy within the protocol of the larger phase 2/3 trial COV002, adults aged 18-55 years with HIV were enrolled at two HIV clinics in London, UK...
August 2021: Lancet HIV
https://read.qxmd.com/read/33989558/loncastuximab-tesirine-in-relapsed-or-refractory-diffuse-large-b-cell-lymphoma-lotis-2-a-multicentre-open-label-single-arm-phase-2-trial
#13
MULTICENTER STUDY
Paolo F Caimi, Weiyun Ai, Juan Pablo Alderuccio, Kirit M Ardeshna, Mehdi Hamadani, Brian Hess, Brad S Kahl, John Radford, Melhem Solh, Anastasios Stathis, Pier Luigi Zinzani, Karin Havenith, Jay Feingold, Shui He, Yajuan Qin, David Ungar, Xiaoyan Zhang, Carmelo Carlo-Stella
BACKGROUND: Patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who do not respond to or who have progressive disease after salvage therapies have a poor prognosis. Loncastuximab tesirine is a CD19-directed antibody-drug conjugate with encouraging phase 1 single-agent antitumour activity and acceptable safety in non-Hodgkin lymphoma. We aimed to evaluate the antitumour activity and safety of loncastuximab tesirine in patients with relapsed or refractory DLBCL. METHODS: We did a multicentre (28 hospital sites in the USA, UK, Italy, and Switzerland), open-label, single-arm, phase 2 trial (LOTIS-2) in patients aged 18 years or older with relapsed or refractory DLBCL after two or more multiagent systemic treatments, who had measurable disease and Eastern Cooperative Oncology Group performance status 0-2...
June 2021: Lancet Oncology
https://read.qxmd.com/read/33970149/sample-preparation-and-transfer-protocol-for-in-vacuum-long-wavelength-crystallography-on-beamline-i23-at-diamond-light-source
#14
JOURNAL ARTICLE
Ramona Duman, Christian M Orr, Vitaliy Mykhaylyk, Kamel El Omari, Robert Pocock, Vinay Grama, Armin Wagner
Long-wavelength macromolecular crystallography (MX) exploits the anomalous scattering properties of elements, such as sulfur, phosphorus, potassium, chlorine, or calcium, that are often natively present in macromolecules. This enables the direct structure solution of proteins and nucleic acids via experimental phasing without the need of additional labelling. To eliminate the significant air absorption of X-rays in this wavelength regime, these experiments are performed in a vacuum environment. Beamline I23 at Diamond Light Source, UK, is the first synchrotron instrument of its kind, designed and optimized for MX experiments in the long wavelength range towards 5 Å...
April 23, 2021: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/33835829/first-report-of-fusarium-proliferatum-causing-garlic-clove-rot-in-russian-federation
#15
JOURNAL ARTICLE
Olga K Anisimova, Timofey M Seredin, Olga A Danilova, Mikhail Filyushin
Garlic ( Allium sativum L. ) is a widely consumed bulbous crop both worldwide and in Russia. About 200,000 tons of garlic is produced in Russia annually (https://rosstat.gov.ru/). Significant pre- and post-harvest losses of garlic regularly occur due to Fusarium sp. (Taylor et al., 2013). Since September 2018, rotting has been observed in Russia during garlic bulb storage (data of the Federal Scientific Vegetable Center, FSVC, Moscow Region). The outer bulb surface looked healthy, but underneath the integumentary scales, the cloves had light brown and brown spots...
April 9, 2021: Plant Disease
https://read.qxmd.com/read/33630275/daratumumab-monotherapy-for-relapsed-or-refractory-multiple-myeloma-results-of-an-early-access-treatment-protocol-in-europe-and-russia
#16
JOURNAL ARTICLE
Gordon Cook, Alessandro Corso, Matthew Streetly, Larisa P Mendeleeva, Vadim V Ptushkin, Edmond Chan, Jon Ukropec, Wafae Iraqi, Assem Al-Akabawi, Huiling Pei, Maren Gaudig, Maria Teresa Petrucci, Adrian Alegre, Maria-Victoria Mateos
INTRODUCTION: Daratumumab is a human IgGκ monoclonal antibody targeting CD38. Despite the demonstrated benefit of daratumumab in multiple myeloma, not all patients have access to commercially available daratumumab. Here we report a pooled analysis of patients from the UK, Spain, Italy, and Russia enrolled in an open-label, early access treatment protocol (EAP) that provided daratumumab (16 mg/kg) monotherapy to patients with heavily pre-treated relapsed or refractory multiple myeloma (RRMM)...
June 2021: Oncology and Therapy
https://read.qxmd.com/read/33598647/adverse-muscle-composition-is-linked-to-poor-functional-performance-and-metabolic-comorbidities-in-nafld
#17
JOURNAL ARTICLE
Jennifer Linge, Mattias Ekstedt, Olof Dahlqvist Leinhard
BACKGROUND & AIMS: Sarcopenia and frailty are recognised as important factors in later stages of liver disease. However, their role in non-alcoholic fatty liver disease (NAFLD) is not yet fully understood. In this study we investigate the associations of MRI-measured adverse muscle composition (AMC: low muscle volume and high muscle fat) with poor function, sarcopenia, and metabolic comorbidity within NAFLD in the large UK Biobank imaging study. METHODS: A total of 9,545 participants were included...
February 2021: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/33217361/safety-and-immunogenicity-of-a-two-dose-heterologous-ad26-zebov-and-mva-bn-filo-ebola-vaccine-regimen-in-adults-in-europe-ebovac2-a-randomised-observer-blind-participant-blind-placebo-controlled-phase-2-trial
#18
RANDOMIZED CONTROLLED TRIAL
Andrew J Pollard, Odile Launay, Jean-Daniel Lelievre, Christine Lacabaratz, Sophie Grande, Neil Goldstein, Cynthia Robinson, Auguste Gaddah, Viki Bockstal, Aurelie Wiedemann, Maarten Leyssen, Kerstin Luhn, Laura Richert, Christine Bétard, Malick M Gibani, Elizabeth A Clutterbuck, Matthew D Snape, Yves Levy, Macaya Douoguih, Rodolphe Thiebaut
BACKGROUND: To address the unmet medical need for an effective prophylactic vaccine against Ebola virus we assessed the safety and immunogenicity of three different two-dose heterologous vaccination regimens with a replication-deficient adenovirus type 26 vector-based vaccine (Ad26.ZEBOV), expressing Zaire Ebola virus glycoprotein, and a non-replicating, recombinant, modified vaccinia Ankara (MVA) vector-based vaccine, encoding glycoproteins from Zaire Ebola virus, Sudan virus, and Marburg virus, and nucleoprotein from the Tai Forest virus...
April 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33164079/cardiovascular-magnetic-resonance-imaging-in-the-uk-biobank-a-major-international-health-research-resource
#19
JOURNAL ARTICLE
Zahra Raisi-Estabragh, Nicholas C Harvey, Stefan Neubauer, Steffen E Petersen
The UK Biobank (UKB) is a health research resource of major international importance, incorporating comprehensive characterization of >500 000 men and women recruited between 2006 and 2010 from across the UK. There is prospective tracking of health outcomes for all participants through linkages with national cohorts (death registers, cancer registers, electronic hospital records, and primary care records). The dataset has been enhanced with the UKB imaging study, which aims to scan a subset of 100 000 participants...
February 22, 2021: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/32937602/ipem-topical-report-an-evidence-and-risk-assessment-based-analysis-of-the-efficacy-of-quality-assurance-tests-on-fluoroscopy-units-part-ii-image-quality
#20
JOURNAL ARTICLE
Dan Shaw, Mark Worrall, Chris Baker, Paul Charnock, Jason Fazakerley, Ian Honey, Gareth Iball, Manthos Koutalonis, Mandy Price, Caroline Renaud, Amy Rose, Tim Wood
This work aims to assess the efficacy of x-ray quality assurance tests undertaken on fluoroscopy units in the UK. Information was gathered on the results of image quality tests recommended by the reports of the Institute of Physics and Engineering in Medicine, and those additionally undertaken by medical physics departments. The assessment of efficacy considers the frequency with which a test result breaches the remedial level or other relevant threshold where applicable. The third quartile of those results exceeding the remedial level or threshold is used to estimate the severity of such a breach in terms of potential impact on patient dose and image quality...
December 5, 2020: Physics in Medicine and Biology
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