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https://www.readbyqxmd.com/read/30120069/safety-and-immunogenicity-of-a-pentavalent-meningococcal-conjugate-vaccine-containing-serogroups-a-c-y-w-and-x-in-healthy-adults-a-phase-1-single-centre-double-blind-randomised-controlled-study
#1
Wilbur H Chen, Kathleen M Neuzil, C Rebecca Boyce, Marcela F Pasetti, Mardi K Reymann, Lionel Martellet, Nancy Hosken, F Marc LaForce, Rajeev M Dhere, Sambhaji S Pisal, Amol Chaudhari, Prasad S Kulkarni, Ray Borrow, Helen Findlow, Valerie Brown, Megan L McDonough, Len Dally, Mark R Alderson
BACKGROUND: Invasive meningococcal disease is an important public health problem, especially in sub-Saharan Africa. After introduction of MenAfriVac in 2010, Neisseria meningitidis serogroup A disease has been almost eliminated from the region. However, serogroups C, W, Y, and X continue to cause disease outbreaks. We assessed the NmCV-5 pentavalent meningococcal conjugate vaccine targeting A, C, Y, W, and X serogroups in a first-in-man, phase 1 study. METHODS: We did a single-centre, double-blind, randomised controlled trial at a research clinic in Baltimore (MD, USA)...
August 14, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29960848/relapse-of-wilms-tumour-and-detection-methods-a-retrospective-analysis-of-the-2001-renal-tumour-study-group-international-society-of-paediatric-oncology-wilms-tumour-protocol-database
#2
Jesper Brok, Marta Lopez-Yurda, Harm V Tinteren, Taryn D Treger, Rhoikos Furtwängler, Norbert Graf, Christophe Bergeron, Marry M van den Heuvel-Eibrink, Kathy Pritchard-Jones, Øystein E Olsen, Beatriz de Camargo, Arnauld Verschuur, Filippo Spreafico
BACKGROUND: Wilms' tumour is the most common renal cancer in childhood and about 15% of patients will relapse. There is scarce evidence about optimal surveillance schedules and methods for detection of tumour relapse after therapy. METHODS: The Renal Tumour Study Group-International Society of Paediatric Oncology (RTSG-SIOP) Wilms' tumour 2001 trial and study is an international, multicentre, prospective registration, biological study with an embedded randomised clinical trial for children with renal tumours aged between 6 months and 18 years...
August 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29514706/the-role-of-ixazomib-as-an-augmented-conditioning-therapy-in-salvage-autologous-stem-cell-transplant-asct-and-as-a-post-asct-consolidation-and-maintenance-strategy-in-patients-with-relapsed-multiple-myeloma-accord-uk-mra-myeloma-xii-trial-study-protocol-for
#3
Alina Striha, A John Ashcroft, Anna Hockaday, David A Cairns, Karen Boardman, Gwen Jacques, Cathy Williams, John A Snowden, Mamta Garg, Jamie Cavenagh, Kwee Yong, Mark T Drayson, Roger Owen, Mark Cook, Gordon Cook
BACKGROUND: Multiple myeloma (MM) is a plasma cell tumour with an approximate annual incidence of 4500 in the UK. Therapeutic options for patients with MM have changed in the last decade with the arrival of proteasome inhibitors and immunomodulatory drugs. Despite these options, almost all patients will relapse post first-line autologous stem cell transplantation (ASCT). First relapse management (second-line treatment) has evolved in recent years with an expanding portfolio of novel agents, driving response rates influencing the durability of response...
March 7, 2018: Trials
https://www.readbyqxmd.com/read/29374670/care-cr-cardiovascular-and-cardiorespiratory-adaptations-to-routine-exercise-based-cardiac-rehabilitation-a-study-protocol-for-a-community-based-controlled-study-with-criterion-methods
#4
Simon Nichols, Fiona Nation, Toni Goodman, Andrew L Clark, Sean Carroll, Lee Ingle
INTRODUCTION: Cardiac rehabilitation (CR) reduces all-cause and cardiovascular mortality in patients with coronary heart disease (CHD). Much of this improvement has been attributed to the beneficial effects of structured exercise training. However, UK-based studies have not confirmed this. Improvements in survival and cardiovascular health are associated with concurrent improvements in cardiorespiratory fitness (CRF). It is therefore concerning that estimated CRF improvements resulting from UK-based CR are approximately one-third of those reported in international literature...
January 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29301558/leucine-and-ace-inhibitors-as-therapies-for-sarcopenia-lace-trial-study-protocol-for-a-randomised-controlled-trial
#5
Margaret M Band, Deepa Sumukadas, Allan D Struthers, Alison Avenell, Peter T Donnan, Paul R Kemp, Karen T Smith, Cheryl L Hume, Adrian Hapca, Miles D Witham
BACKGROUND: Sarcopenia (the age-related loss of muscle mass and function) is a major contributor to loss of mobility, falls, loss of independence, morbidity and mortality in older people. Although resistance training is effective in preventing and reversing sarcopenia, many older people are sedentary and either cannot or do not want to exercise. This trial examines the efficacy of supplementation with the amino acid leucine and/or angiotensin converting enzyme inhibition to potentially improve muscle mass and function in people with sarcopenia...
January 4, 2018: Trials
https://www.readbyqxmd.com/read/29079522/image-processing-and-quality-control-for-the-first-10-000-brain-imaging-datasets-from-uk-biobank
#6
Fidel Alfaro-Almagro, Mark Jenkinson, Neal K Bangerter, Jesper L R Andersson, Ludovica Griffanti, Gwenaëlle Douaud, Stamatios N Sotiropoulos, Saad Jbabdi, Moises Hernandez-Fernandez, Emmanuel Vallee, Diego Vidaurre, Matthew Webster, Paul McCarthy, Christopher Rorden, Alessandro Daducci, Daniel C Alexander, Hui Zhang, Iulius Dragonu, Paul M Matthews, Karla L Miller, Stephen M Smith
UK Biobank is a large-scale prospective epidemiological study with all data accessible to researchers worldwide. It is currently in the process of bringing back 100,000 of the original participants for brain, heart and body MRI, carotid ultrasound and low-dose bone/fat x-ray. The brain imaging component covers 6 modalities (T1, T2 FLAIR, susceptibility weighted MRI, Resting fMRI, Task fMRI and Diffusion MRI). Raw and processed data from the first 10,000 imaged subjects has recently been released for general research access...
February 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/27638987/joint-sogc-ccmg-opinion-for-reproductive-genetic-carrier-screening-an-update-for-all-canadian-providers-of-maternity-and-reproductive-healthcare-in-the-era-of-direct-to-consumer-testing
#7
R Douglas Wilson, Isabelle De Bie, Christine M Armour, Richard N Brown, Carla Campagnolo, June C Carroll, Nan Okun, Tanya Nelson, Rhonda Zwingerman, Francois Audibert, Jo-Ann Brock, Richard N Brown, Carla Campagnolo, June C Carroll, Isabelle De Bie, Jo-Ann Johnson, Nan Okun, Melanie Pastruck, Karine Vallée-Pouliot, R Douglas Wilson, Rhonda Zwingerman, Christine Armour, David Chitayat, Isabelle De Bie, Sara Fernandez, Raymond Kim, Josee Lavoie, Norma Leonard, Tanya Nelson, Sherry Taylor, Margot Van Allen, Clara Van Karnebeek
OBJECTIVE: This guideline was written to update Canadian maternity care and reproductive healthcare providers on pre- and postconceptional reproductive carrier screening for women or couples who may be at risk of being carriers for autosomal recessive (AR), autosomal dominant (AD), or X-linked (XL) conditions, with risk of transmission to the fetus. Four previous SOGC- Canadian College of Medical Geneticists (CCMG) guidelines are updated and merged into the current document. INTENDED USERS: All maternity care (most responsible health provider [MRHP]) and paediatric providers; maternity nursing; nurse practitioner; provincial maternity care administrator; medical student; and postgraduate resident year 1-7...
August 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27251904/clinical-leishmaniasis-in-dogs-living-in-the-uk
#8
P Silvestrini, D Batchelor, K Allenspach, C Maunder, M Seth, A Mas, T Hill, G Serrano, X Roura, M Planellas, A J German, J Pastor
OBJECTIVES: To investigate the prevalence of leishmaniasis in dogs in the UK and to describe clinical presentation, clinicopathological abnormalities, therapeutic protocols and outcome in this non-endemic country. MATERIALS AND METHODS: Medical records of dogs diagnosed with leishmaniasis at seven referral centres in the UK were retrospectively reviewed. RESULTS: The prevalence was between 0·007 and 0·04% with a higher number of cases in southern England...
September 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/26578859/ica-based-artifact-removal-diminishes-scan-site-differences-in-multi-center-resting-state-fmri
#9
Rogier A Feis, Stephen M Smith, Nicola Filippini, Gwenaëlle Douaud, Elise G P Dopper, Verena Heise, Aaron J Trachtenberg, John C van Swieten, Mark A van Buchem, Serge A R B Rombouts, Clare E Mackay
Resting-state fMRI (R-fMRI) has shown considerable promise in providing potential biomarkers for diagnosis, prognosis and drug response across a range of diseases. Incorporating R-fMRI into multi-center studies is becoming increasingly popular, imposing technical challenges on data acquisition and analysis, as fMRI data is particularly sensitive to structured noise resulting from hardware, software, and environmental differences. Here, we investigated whether a novel clean up tool for structured noise was capable of reducing center-related R-fMRI differences between healthy subjects...
2015: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/26539632/experiences-of-using-a-commercial-dose-management-system-ge-dosewatch-for-ct-examinations
#10
Ruth M Nicol, Sarah C Wayte, Andrew J Bridges, Christopher J Koller
OBJECTIVE: To assess the use of a commercial dose management system (GE DoseWatch; GEMS, Milwaukee, WI) for CT dose management for six common CT examinations. METHODS: Data were acquired over several months using GE DoseWatch for six common CT examinations on three CT scanners. The dose length product (DLP) was taken as the dose indicator. The data were analysed using four different filtering methods: study description, the National Interim Clinical Imaging Procedure code, protocol name and a more detailed filtering method (the reference data set)...
2016: British Journal of Radiology
https://www.readbyqxmd.com/read/26238197/extrinsic-tooth-staining-potential-of-high-dose-and-sustained-release-iron-syrups-on-primary-teeth
#11
COMPARATIVE STUDY
Sharat Chandra Pani, Fahad Murdhi Alenazi, Abdullah Muhammad Alotain, Hamad Daher Alanazi, Abdullah Saeed Alasmari
BACKGROUND: Iron in the form of oral supplements is routinely prescribed to children to help fight anemia, however tooth staining is a commonly reported complication. This study tests in vitro, the staining potential of two different forms of iron syrup on primary teeth. METHODS: Forty caries free primary central incisors were divided into four groups of ten teeth each. The control group comprised of ten teeth immersed in artificial saliva, while the test solutions were comprised of different forms of iron mixed with vitamins such that the iron content of each solution was approximately 100 mg (from 100 to 101...
August 4, 2015: BMC Oral Health
https://www.readbyqxmd.com/read/26119344/evaluation-of-the-effective-dose-of-cone-beam-ct-and-multislice-ct-for-temporomandibular-joint-examinations-at-optimized-exposure-levels
#12
COMPARATIVE STUDY
N Kadesjö, D Benchimol, B Falahat, K Näsström, X-Q Shi
OBJECTIVES: To compare the effective dose to patients from temporomandibular joint examinations using a dental CBCT device and a multislice CT (MSCT) device, both before and after dose optimization. METHODS: A Promax(®) 3D (Planmeca, Helsinki, Finland) dental CBCT and a LightSpeed VCT(®) (GE Healthcare, Little Chalfont, UK) multislice CT were used. Organ doses and effective doses were estimated from thermoluminescent dosemeters at 61 positions inside an anthropomorphic phantom at the exposure settings in clinical use...
2015: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/26102272/regional-cerebral-blood-flow-single-photon-emission-computed-tomography-for-detection-of-frontotemporal-dementia-in-people-with-suspected-dementia
#13
REVIEW
Hilary A Archer, Nadja Smailagic, Christeena John, Robin B Holmes, Yemisi Takwoingi, Elizabeth J Coulthard, Sarah Cullum
BACKGROUND: In the UK, dementia affects 5% of the population aged over 65 years and 25% of those over 85 years. Frontotemporal dementia (FTD) represents one subtype and is thought to account for up to 16% of all degenerative dementias. Although the core of the diagnostic process in dementia rests firmly on clinical and cognitive assessments, a wide range of investigations are available to aid diagnosis.Regional cerebral blood flow (rCBF) single-photon emission computed tomography (SPECT) is an established clinical tool that uses an intravenously injected radiolabelled tracer to map blood flow in the brain...
June 23, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26083878/a-practical-method-to-standardise-and-optimise-the-philips-doseright-2-0-ct-automatic-exposure-control-system
#14
T J Wood, C S Moore, A Stephens, J R Saunderson, A W Beavis
Given the increasing use of computed tomography (CT) in the UK over the last 30 years, it is essential to ensure that all imaging protocols are optimised to keep radiation doses as low as reasonably practicable, consistent with the intended clinical task. However, the complexity of modern CT equipment can make this task difficult to achieve in practice. Recent results of local patient dose audits have shown discrepancies between two Philips CT scanners that use the DoseRight 2.0 automatic exposure control (AEC) system in the 'automatic' mode of operation...
September 2015: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/24927811/a-prospective-observational-study-to-assess-the-diagnostic-accuracy-of-clinical-decision-rules-for-children-presenting-to-emergency-departments-after-head-injuries-protocol-the-australasian-paediatric-head-injury-rules-study-aphirst
#15
MULTICENTER STUDY
Franz E Babl, Mark D Lyttle, Silvia Bressan, Meredith Borland, Natalie Phillips, Amit Kochar, Stuart R Dalziel, Sarah Dalton, John A Cheek, Jeremy Furyk, Yuri Gilhotra, Jocelyn Neutze, Brenton Ward, Susan Donath, Kim Jachno, Louise Crowe, Amanda Williams, Ed Oakley
BACKGROUND: Head injuries in children are responsible for a large number of emergency department visits. Failure to identify a clinically significant intracranial injury in a timely fashion may result in long term neurodisability and death. Whilst cranial computed tomography (CT) provides rapid and definitive identification of intracranial injuries, it is resource intensive and associated with radiation induced cancer. Evidence based head injury clinical decision rules have been derived to aid physicians in identifying patients at risk of having a clinically significant intracranial injury...
June 13, 2014: BMC Pediatrics
https://www.readbyqxmd.com/read/24699200/estimation-of-mean-glandular-dose-for-contrast-enhanced-digital-mammography-factors-for-use-with-the-uk-european-and-iaea-breast-dosimetry-protocols
#16
D R Dance, K C Young
The UK, European and IAEA protocols for breast dosimetry in mammography use tabulations of conversion factors, which relate measurements of incident air kerma to the mean glandular dose to the breast. To supplement the existing tabulations, a Monte Carlo computer program has been used to calculate conversion factors for the high-energy spectra used for contrast enhanced digital mammography. The calculations were made for the x-ray spectra from a tungsten target (tube voltage range 40-50 kV) filtered by 0.28, 0...
May 7, 2014: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/24649807/annual-computed-tomography-scans-do-not-improve-outcomes-following-esophagectomy-for-cancer-a-10-year-uk-experience
#17
S S Antonowicz, B Lorenzi, M Parker, C B Tang, M Harvey, S S Kadirkamanathan
Evidence for the best approach to follow-up patients after esophagectomy for cancer is scant and conflicting, and has led to a wide variety in practice. The aim of this study was to evaluate whether our annual routine computed tomography (aCT) scan program changes outcomes. A retrospective review of 169 patients who underwent esophagectomy for cancer in our unit between 2001 and 2010 was performed. aCT scan was part of follow-up in all patients to 5 years. Minimum follow-up was 37 months. The primary outcome measure was survival...
May 2015: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/23571817/18f-dopa-pet-and-enhanced-ct-imaging-for-congenital-hyperinsulinism-initial-uk-experience-from-a-technologist-s-perspective
#18
Marguerite Meintjes, Raymond Endozo, John Dickson, Kjel Erlandsson, Khalid Hussain, Caroline Townsend, Leon Menezes, Jamshed Bomanji
INTRODUCTION: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in infants and children. Histologically, there are two subgroups, diffuse and focal. The aim of this study was to evaluate the accuracy of (18)F-fluoro-L-dihydroxyphenylalanine ((18)F-DOPA) PET/computed tomography (CT) and contrast-enhanced CT in distinguishing between focal and diffuse lesions in infants with CHI who are unresponsive to medical therapy. In addition, this paper describes the detailed protocol used for imaging and analysis of (18)F-DOPA PET/CT images in our clinical practice...
June 2013: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/23072576/surgical-trial-in-traumatic-intracerebral-hemorrhage-stitch-trauma-study-protocol-for-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Barbara A Gregson, Elise N Rowan, Patrick M Mitchell, Andy Unterberg, Elaine M McColl, Iain R Chambers, Paul McNamee, A David Mendelow
BACKGROUND: Intracranial hemorrhage occurs in over 60% of severe head injuries in one of three types: extradural (EDH); subdural (SDH); and intraparenchymal (TICH). Prompt surgical removal of significant SDH and EDH is established and widely accepted. However, TICH is more common and is found in more than 40% of severe head injuries. It is associated with a worse outcome but the role for surgical removal remains undefined. Surgical practice in the treatment of TICHs differs widely around the world...
October 16, 2012: Trials
https://www.readbyqxmd.com/read/22514101/perfusion-ct-to-assess-angiogenesis-in-colon-cancer-technical-limitations-and-practical-challenges
#20
MULTICENTER STUDY
S Dighe, E Castellano, H Blake, N Jeyadevan, M U Koh, M Orten, I Swift, G Brown
OBJECTIVE: Perfusion CT may have the potential to quantify the degree of angiogenesis of solid tumours in vivo. This study aims to identify the practical and technical challenges inherent to the technique, and evaluate its feasibility in colorectal tumours. METHODS: 51 patients from 2 institutions prospectively underwent a single perfusion CT on 2 different multidetector scanners. The patients were advised to breath-hold as long as possible, followed by shallow breathing, and were given intravenous buscopan to reduce movement...
October 2012: British Journal of Radiology
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