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L-Arginine Cancer

Kamil Kus, Agnieszka Kij, Agnieszka Zakrzewska, Agnieszka Jasztal, Marta Stojak, Maria Walczak, Stefan Chlopicki
BACKGROUND: The early detection of metastasis based on biomarkers in plasma may improve cancer prognosis and guide treatment. The aim of this work was to characterize alterations in metabolites of the arginine pathway, energy metabolism, and structural and signalling lipids in plasma in the early and late stages of murine breast cancer metastasis. METHODS: Mice were orthotopically inoculated with 4T1 metastatic breast cancer cells, and plasma was analysed along the pulmonary metastasis progression using LC-MS/MS-based targeted metabolomics and lipidomics...
December 4, 2018: Breast Cancer Research: BCR
Srinidi Mohan, Seema Patel, Ian Greenstein, Cathy Ng, Kelly Frazier, Giang Nguyen, Lisa Harding, David Barlow
We found a unit error with our LC-MS lower limit of quantitation (LLOQ) measurement in the Amino Acids Journal.
November 17, 2018: Amino Acids
A E Yuzhalin, A N Gordon-Weeks, M L Tognoli, K Jones, B Markelc, R Konietzny, R Fischer, A Muth, E O'Neill, P R Thompson, P J Venables, B M Kessler, S Y Lim, R J Muschel
Citrullination of proteins, a post-translational conversion of arginine residues to citrulline, is recognized in rheumatoid arthritis, but largely undocumented in cancer. Here we show that citrullination of the extracellular matrix by cancer cell derived peptidylarginine deiminase 4 (PAD4) is essential for the growth of liver metastases from colorectal cancer (CRC). Using proteomics, we demonstrate that liver metastases exhibit higher levels of citrullination and PAD4 than unaffected liver, primary CRC or adjacent colonic mucosa...
November 14, 2018: Nature Communications
Mozhgan Jahani, Mehri Azadbakht, Hassan Rasouli, Reza Yarani, Davood Rezazadeh, Nader Salari, Kamran Mansouri
Reducing the adverse effects of chemotherapy on normal cells such as endothelial cells is a determinant factor of treatment success especially in pregnant women. In this regard, modulatory effect of L-arginine on various cancers is still a controversial topic in cancer therapy. So, this study aimed to compare the effect of L-arginine treatment alone and in combination with 5-fluorouracil (5-FU) on the survival and angiogenesis of primary human umbilical vein endothelial cells (HUVECs) and the breast cancer cell line of MDA-MB-468...
November 10, 2018: Food and Chemical Toxicology
Jiaming Liang, Jing Wang, Luwei Zhang, Sijia Wang, Cuiping Yao, Zhenxi Zhang
A conductometric immunoassay protocol was designed for the sensitive detection of a liver cancer biomarker, alpha-fetoprotein (AFP), in biological fluids by using enzyme-conjugated nanometer-sized enzyme-doped silica beads. Initially, urease molecules were doped into nanosilica particles by using the reverse micelle method. Thereafter, arginase-labeled anti-AFP antibodies were covalently conjugated onto the surface of the synthesized nanoparticles. The immunoreaction was carried out in a monoclonal anti-AFP capture antibody-coated microplate with a sandwich-type assay format by using bienzyme-functionalized silica nanobeads as the recognition elements...
November 6, 2018: Analyst
Yufu Tang, Yibing Zhang, Chunhui Wang, Zhongyi Sun, Longfei Li, Jiahong Dong, Wenping Zhou
14-3-3ζ, a phosphopeptide-binding molecule, is reportedly overexpressed in the cancerous tissues of patients with hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) protein X (HBx) draws intensive attention in HBV-related HCC because it not only regulates HBV replication, but also promotes carcinogenesis by interacting with various tumor or antitumor molecules. This study is performed to investigate whether and how 14-3-3ζ interacts with HBx. The coimmunoprecipitation (Co-IP) results showed that 14-3-3ζ bond to HBx in HBV-infected Hep3B HCC cells and CSQT-2 portal vein tumor thrombosis (PVTT) cells...
November 2018: Cancer Medicine
Dong-Yang Zhang, Yue Zheng, Hang Zhang, Jing-Hua Sun, Cai-Ping Tan, Liang He, Wei Zhang, Liang-Nian Ji, Zong-Wan Mao
Recently, phosphorescent iridium complexes have demonstrated great potential as anticancer and imaging agents. Dopamine is a melanin-like mimic of mussel adhesive protein that can self-polymerize to form polydopamine (PDA) nanoparticles that demonstrate favorable biocompatibility, near-infrared absorption, and photothermal effects. Herein, PDA nanoparticles are functionalized with β-cyclodextrin (CD) substitutions, which are further assembled with adamantane-modified arginine-glycine-aspartic acid (Ad-RGD) tripeptides to target integrin-rich tumor cells...
October 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Akram Assali, Omid Akhavan, Fatemeh Mottaghitalab, Mohsen Adeli, Rassoul Dinarvand, Shayan Razzazan, Ehsan Arefian, Masoud Soleimani, Fatemeh Atyabi
Introduction: MicroRNA-101 (miR-101) is an intense cancer suppressor with special algorithm to target a wide range of pathways and genes which indicates the ability to regulate apoptosis, cellular stress, metastasis, autophagy, and tumor growth. Silencing of some genes such as Stathmin1 with miR-101 can be interpreted as apoptotic accelerator and autophagy suppressor. It is hypothesized that hybrid microRNA (miRNA) delivery structures based on cationized graphene oxide (GO) could take superiority of targeting and photothermal therapy to suppress the cancer cells...
2018: International Journal of Nanomedicine
Kui Deng, Peng Han, Wei Song, Zhuozhong Wang, Fan Zhang, Hongyu Xie, Weiwei Zhao, Huan Xu, Yuqing Cai, Zhiwei Rong, Xiwen Yu, Bin-Bin Cui, Kang Li
BACKGROUND: Many studies have demonstrated that right-sided colon cancer (RCC) has a higher mortality rate and worse prognosis than left-sided colon cancer (LCC). However, the underlying biological mechanism that can account for these differences is unclear. METHODS: In this study, plasma metabolic profiles in 147 LCC patients and 105 RCC patients were systematically analyzed by the ultra high performance liquid chromatography quadruple time-of-flight mass spectrometry (UHPLC-QTOF/MS) platform in conjunction with univariate and multivariate statistical analysis...
October 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Vineet Sadarangani, Safikur Rahman, Apurba Kumar Sau
Recent studies have highlighted the therapeutic importance of bimetallic human arginase-I against hyperargininemia and L-arginine auxotrophic cancers. The longer retention of catalytic activity of the Co2+ -enzyme than that of the Mn2+ in human serum is associated with its enhanced therapeutic potential. To understand the basis of this and also to explore the role of a bimetallic center as well as the role of individual metal ions in the stability, we performed a detailed biochemical and biophysical investigation...
November 2018: Biochimica et biophysica acta. Proteins and proteomics
Tadashi Yamamuro, Kana Inoue, Yasuki Nagai, Daisuke Azuma, Aya Yamamoto, Kantaro Hara, Masaharu Kohara, Takashi Iwata, Shinichi Nakatsuka, Eiichi Morii, Tsunehiko Yamamoto
Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Several types of Cushingoid features were found on physical examination. In addition, laboratory examination showed elevated plasma ACTH and serum cortisol levels...
September 20, 2018: Endocrine Journal
Waliul Islam, Jun Fang, Takahisa Imamura, Tomáš Etrych, Vladimir Subr, Karel Ulbrich, Hiroshi Maeda
Enhanced permeability and retention (EPR) effect-based nanomedicine is a promising strategy for successful anticancer therapy. The EPR effect is based on tumor blood flow. Because advanced large tumors, as frequently seen in clinical settings, are heterogeneous, with regions of defective vasculature and blood flow, achieving the desired tumor drug delivery is difficult. Here, we utilized the EPR effect to increase drug delivery. To augment the EPR effect for improved therapeutic effects of nanomedicine, we exploited vascular mediators-the nitric oxide (NO) generators nitroglycerin (NG), hydroxyurea, and L-arginine...
September 19, 2018: Molecular Cancer Therapeutics
Pinghua Ling, Caihua Qian, Feng Gao, Jianping Lei
An enzyme-immobilized metal-organic framework (MOF) nanosheet system was developed as a tandem catalyst, which converted glucose into gluconic acid and H2O2, and sequentially the latter could be used to catalyze the oxidation of l-arginine to generate nitric oxide in the presence of porphyrinic MOFs as artificial enzymes under physiological pH, showing great potential in cancer depleting glucose for starving-like/gas therapy.
October 2, 2018: Chemical Communications: Chem Comm
Mia Aaboe Jørgensen, Morten Orebo Holmström, Evelina Martinenaite, Caroline Hasselbalch Riley, Hans Carl Hasselbalch, Mads Hald Andersen
Compelling evidence supports the existence of a profound immune dysregulation in patients with chronic myeloproliferative neoplasms (MPN). Increased Arginase-1 expression has been described in MPN patients and in solid cancers. This increase contributes to an immunosuppressive tumor microenvironment in MPN patients because of L-arginine depletion by Arginase-1-expressing regulatory cells and cancer cells, which subsequently limits the activation of circulating effector cells. In the present study, we demonstrate that Arginase-1-derived peptides are recognized by T cells among peripheral mononuclear blood cells from MPN patients...
2018: Oncoimmunology
Merav D Shmueli, Limor Levy-Kanfo, Esraa Haj, Alan R Schoenfeld, Ehud Gazit, Daniel Segal
The von Hippel-Lindau (VHL) syndrome is a rare inherited cancer, caused by mutations in the VHL gene, many of which render the VHL protein (pVHL) unstable. pVHL is a tumor-suppressor protein implicated in a variety of cellular processes, most notably in response to changes in oxygen availability, due to its role as part of an E3-ligase complex which targets the hypoxia-inducible factor (HIF) for degradation. Previously we reported, using in silico and in vitro analyses, that common oncogenic VHL mutations render pVHL less stable than the wild-type protein, distort its core domain and as a result reduce the ability of the protein to bind its target HIF-1α...
September 7, 2018: Oncogene
Pierre-Jacques Hamard, Gabriel E Santiago, Fan Liu, Daniel L Karl, Concepcion Martinez, Na Man, Adnan K Mookhtiar, Stephanie Duffort, Sarah Greenblatt, Ramiro E Verdun, Stephen D Nimer
Protein arginine methyltransferase 5 (PRMT5) is overexpressed in many cancer types and is a promising therapeutic target for several of them, including leukemia and lymphoma. However, we and others have reported that PRMT5 is essential for normal physiology. This dependence may become dose limiting in a therapeutic setting, warranting the search for combinatorial approaches. Here, we report that PRMT5 depletion or inhibition impairs homologous recombination (HR) DNA repair, leading to DNA-damage accumulation, p53 activation, cell-cycle arrest, and cell death...
September 4, 2018: Cell Reports
Ziye Dong, Dan Yu, Qingye Liu, Zhenya Ding, Veronica J Lyons, Robert K Bright, Dimitri Pappas, Xinli Liu, Wei Li
Self-floating hollow glass microspheres (HGMS) modified with tumor-specific antibodies have been developed for the capture of circulating tumor cells (CTCs), and have demonstrated effective cell isolation and good viability of isolated cancer cells. However, the capture efficiency decreases dramatically if the spiked cell concentration is low, possibly due to insufficient interactions between cancer cells and the HGMS surface. In order to apply HGMS-based CTC isolation to clinically relevant samples, it is desirable to create nanostructures on the surface of HGMS to enhance cell-surface interactions...
September 13, 2018: Nanoscale
Jingjing Yao, Zhenhua Du, Zibo Li, Shuhui Zhang, Yukun Lin, Haiyun Li, Lin Zhou, Yuehua Wang, Guixi Yan, Xianchuang Wu, Yongjian Duan, Gangjun Du
6-Gingerol (6-G) is the main bioactive component in Ginger (Zingiber officinale Roscoe). The aim of this study was to explore the contribution of macrophage polarization in 6-G-associated anti-cancer effects. In a urethane-induced lung carcinogenic model, lung carcinogenesis was positively correlated with macrophage (F4/80+) infiltration in lung interstitial in the control group. Furthermore, higher numbers of arginase+/F4/80+ M2 cells than iNOS+/F4/80+ M1 cells were observed in interstitial macrophages. Moreover, macrophage depletion by liposome-encapsulated clodronate (LEC) could significantly prevent lung carcinogenesis, whereas pexidartinib promoted lung carcinogenesis...
September 19, 2018: Food & Function
Hsiao P J Voon, Maheshi Udugama, Wendi Lin, Linda Hii, Ruby H P Law, David L Steer, Partha P Das, Jeffrey R Mann, Lee H Wong
An array of oncogenic histone point mutations have been identified across a number of different cancer studies. It has been suggested that some of these mutant histones can exert their effects by inhibiting epigenetic writers. Here, we report that the H3.3 G34R (glycine to arginine) substitution mutation, found in paediatric gliomas, causes widespread changes in H3K9me3 and H3K36me3 by interfering with the KDM4 family of K9/K36 demethylases. Expression of a targeted single-copy of H3.3 G34R at endogenous levels induced chromatin alterations that were comparable to a KDM4 A/B/C triple-knockout...
August 7, 2018: Nature Communications
Ping Ye, Haitao Yin, Xuelian Gu, Yuanyuan Ye, Qingxiao Zhao, Zhaohua Chang, Baosan Han, Xiaoxiang Chen, Peifeng Liu
AIM: Current cryoablation therapy easily induces a high tumor recurrence, it is therefore necessary to develop an effective method to enhance its antitumor efficacy. MATERIALS & METHODS: We solve the aforementioned problem by introducing doxorubicin (DOX) loading methoxy polyethylene glycol-polylactic-co-glycolic acid-poly-L-lysine-cyclic arginine-glycine-aspartic acid peptide nanoparticles (DOX nanoparticles) in the process of cryoablation. RESULTS: The combination of cryoablation and DOX nanoparticles greatly decreases the recurrence rate of breast cancer, which is owing to the specific targeting therapy of DOX nanoparticles for residuary breast cancer cells after cryoablation...
August 1, 2018: Nanomedicine
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