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T wave axis

Anastasia Greenberg, Javad Karimi Abadchi, Clayton T Dickson, Majid H Mohajerani
The signature rhythm of slow-wave forebrain activity is the large amplitude, slow oscillation (SO: ∼1 Hz) made up of alternating synchronous periods of activity and silence at the single cell and network levels. On each wave, the SO originates at a unique location and propagates across the neocortex. Attempts to manipulate SO activity using electrical fields have been shown to entrain cortical networks and enhance memory performance. However, neural activity during this manipulation has remained elusive due to methodological issues in typical electrical recordings...
March 10, 2018: NeuroImage
Unzue Leire, García Eulogio, Rodríguez Rodrigo Francisco José, Parra Jiménez Francisco Javier, Medina Peralta Juan, Díaz-Antón Belen, Rodríguez Del Río Miguel, Fontenla Adolfo, Teijeiro Rodrigo, Rubio-Alonso Belén
OBJECTIVES: The aim of this study is to describe electrocardiographic changes and conduction abnormalities in patients undergoing transcatheter aortic valve implantation (TAVI). METHODS: 76 patients who underwent TAVI using Edwards Sapien 3 prosthesis were included, comparing electrocardiographic registries at admission, post-procedure and before discharge. RESULTS: Patients after TAVI presented a longer PR interval, a wider QRS, and a longer corrected QT, with a left deviation of QRS axis and T waves; reversible changes that tended to correct in the following days after TAVI...
February 20, 2018: Journal of Electrocardiology
Paul S Pagel, Lonnie Dye, Brent T Boettcher, Julie K Freed
OBJECTIVE: Blood flow across the mitral valve during early left ventricular (LV) filling produces a 3-dimensional rotational fluid body, known as a vortex ring, that enhances LV filling efficiency. Diastolic dysfunction is common in elderly patients, but the influence of advanced age on vortex formation is unknown. The authors tested the hypothesis that advanced age is associated with a reduction in LV filling efficiency quantified using vortex formation time (VFT) in octogenarians undergoing coronary artery bypass graft (CABG) surgery...
March 7, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Bence Daniel, Gergely Nagy, Attila Horvath, Zsolt Czimmerer, Ixchelt Cuaranta-Monroy, Szilard Poliska, Tristan T Hays, Sascha Sauer, Jean Francois-Deleuze, Laszlo Nagy
Retinoid X receptor (RXR) is an obligate heterodimeric partner of several nuclear receptors (NRs), and as such a central component of NR signaling regulating the immune and metabolic phenotype of macrophages. Importantly, the binding motifs of RXR heterodimers are enriched in the tissue-selective open chromatin regions of resident macrophages, suggesting roles in subtype specification. Recent genome-wide studies revealed that RXR binds to thousands of sites in the genome, but the mechanistic details how the cistrome is established and serves ligand-induced transcriptional activity remained elusive...
February 28, 2018: Nucleic Acids Research
Syeda Sara Batool Hamdani, Huma Arshad Cheema, Anjum Saeed, Hassan Suleman Malik, Tayaba Sehar
BACKGROUND: Wilson disease (WD) is one of the most common metabolic liver diseases in older children. It has a strong genetic background with autosomal recessive inheritance. WD is a multisystem disorder with predominant hepatic and neurological manifestations and variable age of presentation. The data on cardiac manifestations in children is very limited and only few adult studies are available in the literature. This study was planned to determine the frequency and spectrum of Electrocardiographic (ECG) changes in pediatric WD...
January 2018: Journal of Ayub Medical College, Abbottabad: JAMC
Calum Crake, Spencer T Brinker, Christian M Coviello, Margaret Livingstone, Nathan J McDannold
Previous work has demonstrated that passive acoustic imaging may be used alongside MRI for monitoring of focused ultrasound therapy. However, past implementations have generally made use of either linear arrays originally designed for diagnostic imaging or custom narrowband arrays specific to in-house therapeutic transducer designs, neither of which is fully compatible with clinical MR-guided focused ultrasound devices. Here we have designed an array which is suitable for use within an FDA-approved MR-guided transcranial focused ultrasound device, within the bore of a 3 Tesla clinical MRI scanner...
February 20, 2018: Physics in Medicine and Biology
Wail Ali, Beth A Bubolz, Linh Nguyen, Danny Castro, Jorge Coss-Bu, Michael M Quach, Curtis E Kennedy, Anne E Anderson, Yi-Chen Lai
Objective: Convulsive status epilepticus can exert profound cardiovascular effects in adults including ventricular depolarization-repolarization abnormalities. Whether status epilepticus adversely affects ventricular electrical properties in children is less understood. Therefore, we sought to characterize ventricular alterations and the associated clinical factors in children following convulsive status epilepticus. Methods: We conducted a 2-year retrospective, case-control study...
December 2017: Epilepsia Open
Matthias T Banet, Mark F Spencer, Robert A Raynor
This paper uses wave-optics and signal-to-noise models to explore the estimation accuracy of digital-holographic detection in the off-axis pupil plane recording geometry for deep-turbulence wavefront sensing. In turn, the analysis examines three important parameters: the number of pixels across the width of the focal-plane array, the window radius in the Fourier plane, and the signal-to-noise ratio. By varying these parameters, the wave-optics and signal-to-noise models quantify performance via a metric referred to as the field-estimated Strehl ratio, and the analysis leads to a method for optimal windowing of the turbulence-limited point spread function...
January 20, 2018: Applied Optics
C T Samlan, Nirmal K Viswanathan
Electric-field applied perpendicular to the direction of propagation of paraxial beam through an optical crystal dynamically modifies the spin-orbit interaction (SOI), leading to the demonstration of controllable spin-Hall effect of light (SHEL). The electro- and piezo-optic effects of the crystal modifies the radially symmetric spatial variation in the fast-axis orientation of the crystal, resulting in a complex pattern with different topologies due to the symmetry-breaking effect of the applied field. This introduces spatially-varying Pancharatnam-Berry type geometric phase on to the paraxial beam of light, leading to the observation of SHEL in addition to the spin-to-vortex conversion...
January 31, 2018: Scientific Reports
James T Thackeray, Henri C Hupe, Yong Wang, Jens P Bankstahl, Georg Berding, Tobias L Ross, Johann Bauersachs, Kai C Wollert, Frank M Bengel
BACKGROUND: The local inflammatory tissue response after acute myocardial infarction (MI) determines subsequent healing. Systemic interaction may induce neuroinflammation as a precursor to neurodegeneration. OBJECTIVES: This study sought to assess the influence of MI on cardiac and brain inflammation using noninvasive positron emission tomography (PET) of the heart-brain axis. METHODS: After coronary artery ligation or sham surgery, mice (n = 49) underwent serial whole-body PET imaging of the mitochondrial translocator protein (TSPO) as a marker of activated macrophages and microglia...
January 23, 2018: Journal of the American College of Cardiology
K P Mooley, E Nakar, K Hotokezaka, G Hallinan, A Corsi, D A Frail, A Horesh, T Murphy, E Lenc, D L Kaplan, K De, D Dobie, P Chandra, A Deller, O Gottlieb, M M Kasliwal, S R Kulkarni, S T Myers, S Nissanke, T Piran, C Lynch, V Bhalerao, S Bourke, K W Bannister, L P Singer
GW170817 was the first gravitational wave detection of a binary neutron-star merger1. It was accompanied by radiation across the electromagnetic spectrum and localized2 to the galaxy NGC 4993 at a distance of 40 megaparsecs. It has been proposed that the observed γ-ray, X-ray and radio emission is due to an ultra-relativistic jet launched during the merger, directed away from our line of sight3-6. The presence of such a jet is predicted from models that posit neutron-star mergers as the central engines that drive short hard γ-ray bursts7,8...
December 20, 2017: Nature
T S Chwee, Z C Wong, M B Sullivan, W Y Fan
Computational studies using correlated wave function methods and density functional theory were carried out on a series of acetylene-linked bimane oligomers with particular emphasis on their excitonic properties and implications for intra-chain excitation energy transfer (EET). The low energy barriers found for the rotation of bimane subunits about the longitudinal axis are such that the π-conjugation is easily disrupted. Nevertheless, a distinctive feature of the oligomer lies in the parallel alignment of the S1 transition dipole along the longitudinal axis, which sustains electronic coupling between adjacent bimane subunits over a range of torsional angles and is crucial for driving intra-chain EET...
December 14, 2017: Physical Chemistry Chemical Physics: PCCP
S Beaulieu, A Comby, A Clergerie, J Caillat, D Descamps, N Dudovich, B Fabre, R Géneaux, F Légaré, S Petit, B Pons, G Porat, T Ruchon, R Taïeb, V Blanchet, Y Mairesse
Chiral light-matter interactions have been investigated for two centuries, leading to the discovery of many chiroptical processes used for discrimination of enantiomers. Whereas most chiroptical effects result from a response of bound electrons, photoionization can produce much stronger chiral signals that manifest as asymmetries in the angular distribution of the photoelectrons along the light-propagation axis. We implemented self-referenced attosecond photoelectron interferometry to measure the temporal profile of the forward and backward electron wave packets emitted upon photoionization of camphor by circularly polarized laser pulses...
December 8, 2017: Science
Diego N Moraes, Bruno R Nascimento, Andrea Z Beaton, Elsayed Z Soliman, Maria Fernanda Lima-Costa, Rodrigo C P Dos Reis, Antonio Luiz P Ribeiro
We sought to investigate the prognostic value of the electrocardiogram (ECG) electrical axes (P wave, T wave and QRS) as predictors of mortality in the 14-year follow-up of the prospective cohort of all residents ≥60 years living in the southeastern Brazilian city of Bambuí, a population with high prevalence of Chagas disease (ChD). Baseline ECG axes were automatically measured with normal values defined as follows: P-wave axis 0° to 75°, QRS axis -30° to 90°, and T axis 15° to 75°. Participants underwent annual follow-up visits and death was verified using death certificates...
February 1, 2018: American Journal of Cardiology
M Bartnicki, P Łyp, P Dębiak, M Staniec, S Winiarczyk, K Buczek, Ł Adaszek
The aim of this study was to assess cardiac disorders in dogs infected with B. canis. The study included 50 dogs with babesiosis and 20 healthy control animals. All the animals had haematological tests, ECG, echocardiography and serum troponin I and CK-MB levels checked. The haematology in the group of dogs with babesiosis confirmed thrombocytopaenia in 100% of dogs, decreased haematocrit in 52% and anaemia in 46%. The most common abnormalities in ECG and echocardiography in dogs infected with protozoa included: change in appearance and/or amplitude of the T-wave (34%), increased fractional shortening (24%), an increased sinus rhythm (14%) and heart axis deviation (10%)...
September 26, 2017: Polish Journal of Veterinary Sciences
Christopher J Burke, James S Babb, Ronald S Adler
The aim of this study was to assess changes in shear wave velocity within the pronator quadratus muscle in patients following volar plate fixation for distal radial fractures compared to the contralateral nonoperated side. Shear wave velocity values were obtained in the short and long axis of the pronator quadratus muscle, which were analyzed separately. Patients were also stratified by age below or above 66 years. Statistical analysis was performed using paired sample Wilcoxon signed rank and t tests. Pearson and Spearman rank correlations were also used...
November 2017: Ultrasound: Journal of the British Medical Ultrasound Society
Shmuel Chen, Sarah Hoss, Vicki Zeniou, Ayelet Shauer, Dan Admon, Donna R Zwas, Chaim Lotan, Andre Keren, Israel Gotsman
BACKGROUND: Acute myocarditis carries a variable prognosis. We evaluated the morbidity and mortality rates in patients with acute myocarditis and admission electrocardiographic predictors of outcome. METHODS AND RESULTS: Patients admitted to a tertiary hospital with a clinical diagnosis of acute myocarditis were evaluated; 193 patients were included. Median follow-up was 5.7 years, 82% were male, and overal median age was 30 years (range 21-39). The most common clinical presentations were chest pain (77%) and fever (53%)...
January 2018: Journal of Cardiac Failure
Alan Sugrue, Ram K Rohatgi, Peter A Noseworthy, Vaclav Kremen, J Martijn Bos, Bo Qiang, Yehu Sapir, Zachi I Attia, Christopher G Scott, Peter Brady, Samuel J Asirvatham, Paul A Friedman, Michael J Ackerman
BACKGROUND: Although the hallmark of long-QT syndrome (LQTS) is abnormal cardiac repolarization, there are varying degrees of phenotypic expression and arrhythmic risk. Our aim was to evaluate the performance of a morphological T-wave analysis program in defining breakthrough LQTS arrhythmic risk beyond the QTc value. METHODS AND RESULTS: We analyzed 407 genetically confirmed patients with LQT1 (n=246; 43% men) and LQT2 (n=161; 41% men) over the mean follow-up period of 6...
November 2017: Circulation. Arrhythmia and Electrophysiology
G Hallinan, A Corsi, K P Mooley, K Hotokezaka, E Nakar, M M Kasliwal, D L Kaplan, D A Frail, S T Myers, T Murphy, K De, D Dobie, J R Allison, K W Bannister, V Bhalerao, P Chandra, T E Clarke, S Giacintucci, A Y Q Ho, A Horesh, N E Kassim, S R Kulkarni, E Lenc, F J Lockman, C Lynch, D Nichols, S Nissanke, N Palliyaguru, W M Peters, T Piran, J Rana, E M Sadler, L P Singer
Gravitational waves have been detected from a binary neutron star merger event, GW170817. The detection of electromagnetic radiation from the same source has shown that the merger occurred in the outskirts of the galaxy NGC 4993, at a distance of 40 megaparsecs from Earth. We report the detection of a counterpart radio source that appears 16 days after the event, allowing us to diagnose the energetics and environment of the merger. The observed radio emission can be explained by either a collimated ultra-relativistic jet viewed off-axis, or a cocoon of mildly relativistic ejecta...
October 16, 2017: Science
P A Evans, S B Cenko, J A Kennea, S W K Emery, N P M Kuin, O Korobkin, R T Wollaeger, C L Fryer, K K Madsen, F A Harrison, Y Xu, E Nakar, K Hotokezaka, A Lien, S Campana, S R Oates, E Troja, A A Breeveld, F E Marshall, S D Barthelmy, A P Beardmore, D N Burrows, G Cusumano, A D'Aì, P D'Avanzo, V D'Elia, M de Pasquale, W P Even, C J Fontes, K Forster, J Garcia, P Giommi, B Grefenstette, C Gronwall, D H Hartmann, M Heida, A L Hungerford, M M Kasliwal, H A Krimm, A J Levan, D Malesani, A Melandri, H Miyasaka, J A Nousek, P T O'Brien, J P Osborne, C Pagani, K L Page, D M Palmer, M Perri, S Pike, J L Racusin, S Rosswog, M H Siegel, T Sakamoto, B Sbarufatti, G Tagliaferri, N R Tanvir, A Tohuvavohu
With the first direct detection of merging black holes in 2015, the era of gravitational wave (GW) astrophysics began. A complete picture of compact object mergers, however, requires the detection of an electromagnetic (EM) counterpart. We report ultraviolet (UV) and x-ray observations by Swift and the Nuclear Spectroscopic Telescope ARray (NuSTAR) of the EM counterpart of the binary neutron star merger GW 170817. The bright, rapidly fading ultraviolet emission indicates a high mass (≈ 0.03 solar masses) wind-driven outflow with moderate electron fraction (Ye ≈ 0...
October 16, 2017: Science
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