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https://www.readbyqxmd.com/read/29141844/architectural-t-wave-analysis-and-identification-of-on-therapy-breakthrough-arrhythmic-risk-in-type-1-and-type-2-long-qt-syndrome
#1
Alan Sugrue, Ram K Rohatgi, Peter A Noseworthy, Vaclav Kremen, J Martijn Bos, Bo Qiang, Yehu Sapir, Zachi I Attia, Christopher G Scott, Peter Brady, Samuel J Asirvatham, Paul A Friedman, Michael J Ackerman
BACKGROUND: Although the hallmark of long-QT syndrome (LQTS) is abnormal cardiac repolarization, there are varying degrees of phenotypic expression and arrhythmic risk. Our aim was to evaluate the performance of a morphological T-wave analysis program in defining breakthrough LQTS arrhythmic risk beyond the QTc value. METHODS AND RESULTS: We analyzed 407 genetically confirmed patients with LQT1 (n=246; 43% men) and LQT2 (n=161; 41% men) over the mean follow-up period of 6...
November 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29038372/a-radio-counterpart-to-a-neutron-star-merger
#2
G Hallinan, A Corsi, K P Mooley, K Hotokezaka, E Nakar, M M Kasliwal, D L Kaplan, D A Frail, S T Myers, T Murphy, K De, D Dobie, J R Allison, K W Bannister, V Bhalerao, P Chandra, T E Clarke, S Giacintucci, A Y Q Ho, A Horesh, N E Kassim, S R Kulkarni, E Lenc, F J Lockman, C Lynch, D Nichols, S Nissanke, N Palliyaguru, W M Peters, T Piran, J Rana, E M Sadler, L P Singer
Gravitational waves have been detected from a binary neutron star merger event, GW170817. The detection of electromagnetic radiation from the same source has shown that the merger occurred in the outskirts of the galaxy NGC 4993, at a distance of 40 megaparsecs from Earth. We report the detection of a counterpart radio source that appears 16 days after the event, allowing us to diagnose the energetics and environment of the merger. The observed radio emission can be explained by either a collimated ultra-relativistic jet viewed off-axis, or a cocoon of mildly relativistic ejecta...
October 16, 2017: Science
https://www.readbyqxmd.com/read/29038371/swift-and-nustar-observations-of-gw170817-detection-of-a-blue-kilonova
#3
P A Evans, S B Cenko, J A Kennea, S W K Emery, N P M Kuin, O Korobkin, R T Wollaeger, C L Fryer, K K Madsen, F A Harrison, Y Xu, E Nakar, K Hotokezaka, A Lien, S Campana, S R Oates, E Troja, A A Breeveld, F E Marshall, S D Barthelmy, A P Beardmore, D N Burrows, G Cusumano, A D'Aì, P D'Avanzo, V D'Elia, M de Pasquale, W P Even, C J Fontes, K Forster, J Garcia, P Giommi, B Grefenstette, C Gronwall, D H Hartmann, M Heida, A L Hungerford, M M Kasliwal, H A Krimm, A J Levan, D Malesani, A Melandri, H Miyasaka, J A Nousek, P T O'Brien, J P Osborne, C Pagani, K L Page, D M Palmer, M Perri, S Pike, J L Racusin, S Rosswog, M H Siegel, T Sakamoto, B Sbarufatti, G Tagliaferri, N R Tanvir, A Tohuvavohu
With the first direct detection of merging black holes in 2015, the era of gravitational wave (GW) astrophysics began. A complete picture of compact object mergers, however, requires the detection of an electromagnetic (EM) counterpart. We report ultraviolet (UV) and x-ray observations by Swift and the Nuclear Spectroscopic Telescope ARray (NuSTAR) of the EM counterpart of the binary neutron star merger GW 170817. The bright, rapidly fading ultraviolet emission indicates a high mass (≈ 0.03 solar masses) wind-driven outflow with moderate electron fraction (Ye ≈ 0...
October 16, 2017: Science
https://www.readbyqxmd.com/read/29036130/electromagnetic-diffraction-theory-of-refractive-axicon-lenses
#4
Yangyundou Wang, Shenggang Yan, Ari T Friberg, David Kuebel, Taco D Visser
We study the field that is produced by a paraxial refractive axicon lens. The results from geometrical optics, scalar wave optics, and electromagnetic diffraction theory are compared. In particular, the axial intensity, the on-axis effective wavelength, the transverse intensity, and the far-zone field are examined. A rigorous electromagnetic diffraction analysis shows that the state of polarization of the incident beam strongly affects the transverse intensity distribution, but not the intensity distribution in the far zone...
July 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/28977056/electrocardiographic-findings-in-brazilian-adults-without-heart-disease-elsa-brasil
#5
Marcelo Martins Pinto, Luisa C C Brant, José Luiz Padilha-da-Silva, Murilo Foppa, Paulo A Lotufo, José Geraldo Mill, Paulo R Vasconcelo-Silva, Maria da Conceição C Almeida, Sandhi Maria Barreto, Antônio Luiz Pinho Ribeiro
BACKGROUND: The electrocardiogram (ECG) is widely used in population-based studies. However, there are few studies on electrocardiographic findings in Latin America and in Brazil. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) comprised 15,105 participants (35-74 years) from six Brazilian capitals. OBJECTIVES: To describe electrocardiographic findings in Brazilian adults without heart disease, stratified by sex, age and race/skin color. METHODS: Cross-sectional study with baseline data of 11,094 adults (44...
October 2, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28941601/refining-prediction-of-atrial-fibrillation-risk-in-the-general-population-with-analysis-of-p-wave-axis-from-the-atherosclerosis-risk-in-communities-study
#6
Ankit Maheshwari, Faye L Norby, Elsayed Z Soliman, Ryan Koene, Mary Rooney, Wesley T O'Neal, Alvaro Alonso, Lin Y Chen
Adverse atrial remodeling is associated with increased risk of atrial fibrillation (AF) and can be detected by a shift in P-wave axis. We aimed to determine whether an analysis of P-wave axis can be used to improve risk prediction of AF. We included 15,102 Atherosclerosis Risk in Communities Study participants who were free of AF at baseline. Abnormal P-wave axis (aPWA) was defined as any value outside 0 to 75 degrees on study visit 12-lead electrocardiograms. AF was determined using study visit electrocardiograms, death certificates, and hospital discharge records...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28863167/the-development-and-validation-of-an-easy-to-use-automatic-qt-interval-algorithm
#7
Ben J M Hermans, Arja S Vink, Frank C Bennis, Luc H Filippini, Veronique M F Meijborg, Arthur A M Wilde, Laurent Pison, Pieter G Postema, Tammo Delhaas
BACKGROUND: To evaluate QT-interval dynamics in patients and in drug safety analysis, beat-to-beat QT-interval measurements are increasingly used. However, interobserver differences, aberrant T-wave morphologies and changes in heart axis might hamper accurate QT-interval measurements. OBJECTIVE: To develop and validate a QT-interval algorithm robust to heart axis orientation and T-wave morphology that can be applied on a beat-to-beat basis. METHODS: Additionally to standard ECG leads, the root mean square (ECGRMS), standard deviation and vectorcardiogram were used...
2017: PloS One
https://www.readbyqxmd.com/read/28802985/clinical-analysis-of-48-h-emergency-department-visit-post-outpatient-extracorporeal-shock-wave-lithotripsy-for-urolithiasis
#8
Chin-Heng Lu, Junne-Yih Kuo, Tzu-Ping Lin, Yi-Hsiu Huang, Hsiao-Jen Chung, William J S Huang, Howard H H Wu, Yen-Hwa Chang, Alex T L Lin, Kuang-Kuo Chen
BACKGROUND: Patients suffering from renal or ureteral stones can undergo significant discomfort, even when timely diagnosed and treated. The aim of this study was to assess the risk factors and safety of outpatient Extracorporeal Shock Wave Lithotripsy (ESWL) in the management of patients with renal or ureteral stones. METHODS: In this study, our cohort consisted of 844 outpatients who underwent outpatient ESWL treated between February 2012 and November 2014 at Taipei Veterans General Hospital...
August 9, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28795324/the-fgf23-klotho-axis-and-cardiac-tissue-doppler-imaging-in-pediatric-chronic-kidney-disease-a-prospective-cohort-study
#9
Ylva Tranæus Lindblad, Hannes Olauson, Georgios Vavilis, Ulf Hammar, Maria Herthelius, Jonas Axelsson, Peter Bárány
BACKGROUND: Chronic kidney disease-associated mineral bone disorder (CKD-MBD) is common in pediatric kidney disease patients and a risk factor for future cardiovascular disease (CVD). Fibroblast growth factor-23 (FGF23) and Klotho are novel key players in CKD-MBD, and has been suggested to be involved in the development of CVD. METHODS: This prospective cohort study included 74 pediatric patients; 31 with CKD (age range 0.8-18.8 years, glomerular filtration rate (GFR) range 9-68 mL/min/1...
August 9, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28772106/frontal-plane-t-wave-axis-orientation-predicts-coronary-events-findings-from-the-moli-sani-study
#10
Licia Iacoviello, Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Livia Rago, Amalia De Curtis, Deodato Assanelli, Fabio Badilini, Martino Vaglio, Mariarosaria Persichillo, Peter W Macfarlane, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano
BACKGROUND AND AIMS: The orientation of the frontal plane T-wave axis (T axis) is a reliable measure of ventricular repolarisation. We investigated the association between T-axis and the risk of coronary heart disease (CHD), heart failure (HF), atrial fibrillation (AF), stroke and cardiovascular (CVD) mortality. METHODS: A sample of 21,287 Moli-sani participants randomly recruited from the general adult (≥35 y) Italian population, free of CVD disease, were followed for a median of 4...
July 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28670188/an-uncommon-variant-of-an-uncommon-disease-a-caucasian-adolescent-with-apical-hypertrophic-cardiomyopathy-diagnosed-with-myocardial-perfusion-imaging
#11
Rami Kassem Zein, Zaid Al-Faham, Jason A Mouabbi, Edouard R Daher
Apical hypertrophic cardiomyopathy (ApHCM) is a subtype of HCM. This variant is more common in the Asian population when compared to North American patients. Patients may present with arrhythmias, heart failure, myocardial infarction, chest discomfort, fatigue, and presyncope or syncope. Initial evaluation requires electrocardiogram and two-dimensional echocardiogram. T-wave inversion in the precordial leads as well as hypertrophy of the left ventricle is hallmarks of the disease. Cardiac magnetic resonance (CMR) imaging is the most specific and sensitive imaging modality...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28628222/the-value-of-electrocardiography-in-prognosticating-clinical-deterioration-and-mortality-in-acute-pulmonary-embolism-a-systematic-review-and-meta-analysis
#12
REVIEW
Amro Qaddoura, Geneviève C Digby, Conrad Kabali, Piotr Kukla, Zhong-Qun Zhan, Adrian M Baranchuk
The role of electrocardiography (ECG) in prognosticating pulmonary embolism (PE) is increasingly recognized. ECG is quickly interpretable, noninvasive, inexpensive, and available in remote areas. We hypothesized that ECG can provide useful information about PE prognostication. We searched MEDLINE, EMBASE, Google Scholar, Web of Science, abstracts, conference proceedings, and reference lists through February 2017. Eligible studies used ECG to prognosticate for the main outcomes of death and clinical deterioration or escalation of therapy...
June 19, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28626057/abnormal-p-wave-axis-and-ischemic-stroke-the-aric-study-atherosclerosis-risk-in-communities
#13
Ankit Maheshwari, Faye L Norby, Elsayed Z Soliman, Ryan J Koene, Mary R Rooney, Wesley T O'Neal, Alvaro Alonso, Lin Y Chen
BACKGROUND AND PURPOSE: Abnormal P-wave axis (aPWA) has been linked to incident atrial fibrillation and mortality; however, the relationship between aPWA and stroke has not been reported. We hypothesized that aPWA is associated with ischemic stroke independent of atrial fibrillation and other stroke risk factors and tested our hypothesis in the ARIC study (Atherosclerosis Risk In Communities), a community-based prospective cohort study. METHODS: We included 15 102 participants (aged 54...
August 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28608915/abc-om-pediatrisk-ekg-tolkning
#14
Caroline Fransson, Stefan Johansson, Cecilia Halvorsen
The ABC of paediatric ECG interpretation In paediatric patients, ECG is used as a tool for investigation of arrhythmias, chest pain, syncope, intoxications and congenital heart abnormalities. Paediatric ECGs differ significantly from adult ECGs, and change gradually during childhood, largely because of the changes that start with the transition of foetal circulation at birth. This evolution is most prominent during the first year of life, but it is not until the late adolescent years that the ECG corresponds to that of adults...
June 9, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28546456/electrocardiographic-predictors-of-heart-failure-with-reduced-versus-preserved-ejection-fraction-the-multi-ethnic-study-of-atherosclerosis
#15
Wesley T O'Neal, Matylda Mazur, Alain G Bertoni, David A Bluemke, Mouaz H Al-Mallah, Joao A C Lima, Dalane Kitzman, Elsayed Z Soliman
BACKGROUND: Several markers detected on the routine 12-lead ECG are associated with future heart failure events. We examined whether these markers are able to separate the risk of heart failure with reduced ejection fraction (HFrEF) from heart failure with preserved ejection fraction (HFpEF). METHODS AND RESULTS: We analyzed data of 6664 participants (53% female; mean age 62±10 years) from MESA (Multi-Ethnic Study of Atherosclerosis) who were free of cardiovascular disease at baseline (2000-2002)...
May 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28539979/association-of-metabolic-syndrome-and-electrocardiographic-markers-of-subclinical-cardiovascular-disease
#16
Theodora W Elffers, Renée de Mutsert, Hildo J Lamb, Arie C Maan, Peter W Macfarlane, Ko Willems van Dijk, Frits R Rosendaal, J Wouter Jukema, Stella Trompet
BACKGROUND: The metabolic syndrome (MetS) and its components are well-established risk factors for cardiovascular diseases (CVD). It is inconclusive whether MetS and MetS score are associated with electrocardiographic markers of subclinical CVD, therefore we investigated this in a population without pre-existing CVD. METHODS: We performed a cross-sectional analysis in the Netherlands Epidemiology of Obesity study, a population-based cohort including 6671 participants aged 45-65...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28523642/autosomal-recessive-nonsyndromic-arrhythmogenic-right-ventricular-cardiomyopathy-without-cutaneous-involvements-a-novel-mutation
#17
Mahdieh Soveizi, Bahareh Rabbani, Yousef Rezaei, Sedigheh Saedi, Nasim Najafi, Majid Maleki, Nejat Mahdieh
The arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a genetic disease frequently associated with desmosomal mutations, mainly attributed to dominant mutations in the Plakophilin-2 (PKP2) gene. Naxos and Carvajal are the syndromic forms of ARVD/C due to recessive mutations. Herein, we report an autosomal recessive form of nonsyndromic ARVD/C caused by a mutation in the PKP2 gene. After examination and implementation of diagnostic modalities, the definite diagnosis of ARVD/C was confirmed by detection of ventricular tachycardia with a left bundle branch configuration and a superior axis, T-wave inversion in right precordial leads (i...
May 19, 2017: Annals of Human Genetics
https://www.readbyqxmd.com/read/28505773/relativistic-laser-hosing-instability-suppression-and-electron-acceleration-in-a-preformed-plasma-channel
#18
T W Huang, C T Zhou, H Zhang, S Z Wu, B Qiao, X T He, S C Ruan
The hosing processes of a relativistic laser pulse, electron acceleration, and betatron radiation in a parabolic plasma channel are investigated in the direct laser acceleration regime. It is shown that the laser hosing instability would result in the generation of a randomly directed off-axis electron beam and radiation source with a large divergence angle. While employing a preformed parabolic plasma channel, the restoring force provided by the plasma channel would correct the perturbed laser wave front and thus suppress the hosing instability...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28444249/quantitative-analysis-of-the-3d-cell-shape-changes-driving-soybean-germination
#19
Nátali Maidl Souza, Alexander T Topham, George W Bassel
Seed germination is central to plant establishment and is the starting point for the majority of world agriculture. This transition from seed to seedling has been extensively studied at an organ level, while few studies have examined the cellular events which underlie it. Reports in the model species Arabidopsis have identified a radicle-derived wave of cell expansion underlying the germination process. Whether this spatiotemporal pattern of cell expansion is specific to this model plant or conserved in other species remains unknown...
March 1, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28431057/quantitative-analysis-of-pkp2-and-neighbouring-genes-in-a-patient-with-arrhythmogenic-right-ventricular-cardiomyopathy-caused-by-heterozygous-pkp2-deletion
#20
Keiko Sonoda, Seiko Ohno, Sou Otuki, Koichi Kato, Nobue Yagihara, Hiroshi Watanabe, Takeru Makiyama, Tohru Minamino, Minoru Horie
Aims: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease mainly caused by desmosome gene mutations. The genetic culprit, however, remains elusive in ∼50% of ARVC patients. One of the reasons for missing genetic abnormalities is the difficulty in detecting large deletions/duplications, which are called as copy number variation (CNV) by the Sanger sequencing method. This study aimed to identify CNVs in PKP2 and a part of other desmosome genes in ARVC patients. Methods and Results: The study cohort consisted of 71 ARVC probands who were diagnosed as definite or borderline cases based on 2010 Task Force Criteria...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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