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citrullinated peptide antibody

José Pedro L Nunes, André C Cunha, Tiago Meirinhos, Alzira Nunes, Paulo M Araújo, Ana R Godinho, Eduardo M Vilela, Carlos Vaz
The prevalence of auto-antibodies associated to pulmonary arterial hypertension in scleroderma patients was reviewed, based on reports cited in two major scientific databases. Data was collected on the following types of antibodies: antinuclear, anti-double-stranded DNA, anticentromere, anti-CENP-A, anti-CENP-B, anti-bicaudal D2, anti-nucleolar, anti-Scl-70 (anti-topoisomerase I), anti-topoisomerase II α, anti-RNP, anti-U1RNP, anti-U3RNP, anti-RNA polymerase III, anti-Th/To, anti-histone, antiphospholipid, anti-PmScl, anti-Sm, anti SSA (anti-Ro), anti SSB (La), anti-Ro52 (TRIM 21), anti-Ku, anti-B23, anti-RuvBL1, anti-RuvBL2, anti-fibrin bound tissue plasminogen activator, anti-endothelial cell, anti-phosphatidylserine-prothrombin complex, anti-endothelin-1 type A receptor, anti-angiotensin II type 1 receptor, anti‑carbonic anhydrase II, anti-fibroblast, anti-cyclic citrullinated peptide, anti-4-sulfated N-Acetyl-lactosamine, class I and II anti-human leukocyte antigen...
October 11, 2018: Autoimmunity Reviews
Viviane Malmström, Johanna Steen, Lars Klareskog
Rikard Holmdahl has commented on our recently published paper on specificity and function of human monoclonal antibodies (mAbs) from synovial plasma cells that react with citrullinated proteins and peptides (1). He also comments on our previous study from 2013 (2) that was based on mAbs generated from synovial B cells. Dr Holmdahl's letter provides us with an opportunity to discuss and clarify some methodological issues concerning RA monoclonal autoantibody expression, specificity, and functionality. In our eyes, cloning and characterization of human monoclonal autoantibodies from patients represents an important approach to the understanding of origins and functions of autoantibodies in the pathogenesis of immune-mediated diseases...
October 10, 2018: Arthritis & Rheumatology
G Belakova, V Manka, E Zanova, P Racay
Background: Anti-citrullinated peptides antibodies (ACPA) are specific for rheumatoid arthritis and have been implicated in disease pathogenesis. ACPA examination is a new component of ACR/EULAR 2010 classification criteria for rheumatoid arthritis. ACPA positivity predicts a more erosive disease course with severe joint damage and extra-articular manifestations. Objectives: To evaluate the benefits of ACPA examination in patients with early undifferentiated arthritis and patients with rheumatoid arthritis...
October 2018: Nigerian Journal of Clinical Practice
Lianne P W M Lelieveldt, Hendy Kristyanto, Ger J M Pruijn, Hans Ullrich Scherer, Rene E M Toes, Kimberly M Bonger
Autoreactive B cells are thought to play a pivotal role in many autoimmune diseases. Rheumatoid arthritis (RA) is an autoimmune disease affecting ~1% of the Western population and is hallmarked by the presence of anti-citrullinated proteins antibodies (ACPA) produced by autoreactive B cells. We intend to develop a method to target and selectively eliminate these autoreactive B cells using a sequential antigen prodrug targeting strategy. As ACPA-expressing B cells are thought to play essential roles in RA-disease pathogenesis, we used this B-cell response as prototype to analyze the feasibility to generate a construct consisting of a biologically silenced, i...
October 5, 2018: Molecular Pharmaceutics
Kosuke Shabana, Nami Okamoto, Yuko Sugita, Keisuke Shindo, Takuji Murata, Hiroshi Tamai, Kenta Fujiwara
OBJECTIVE: We researched the findings of musculoskeletal ultrasound sonography (MSUS) on primary Sjogren's syndrome in childhood (pSS-C) with articular manifestations. The correlation of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACPA) were investigated to evaluate the usefulness of MSUS on their articular prognosis. METHOD: The objective patients are pSS-C cases who visited our hospital complaining joint pain and/or joint swelling and for whom MSUS was performed...
October 5, 2018: Modern Rheumatology
Hoshimi Kawaguchi, Isao Matsumoto, Atsumu Osada, Izumi Kurata, Hiroshi Ebe, Yuki Tanaka, Asuka Inoue, Naoto Umeda, Yuya Kondo, Hiroto Tsuboi, Akihito Ishigami, Takayuki Sumida
OBJECTIVE: To explore the relevance of citrullinated proteins and anti-citrullinated protein antibodies (ACPA) via protein arginine deiminase (PAD) inhibition in peptide glucose-6-phosphate isomerase-induced arthritis (pGIA). METHODS: Cl-amidine, a PAD inhibitor, was injected into pGIA. Clinical scores and histopathological findings of ankle joints were assessed. Serum ACPA titers were analyzed using ELISA. Citrullinated protein expression in joints and sera were examined with immunohistochemistry and Western blot analysis, respectively...
October 4, 2018: Modern Rheumatology
Kristine Germar, Cynthia M Fehres, Hans U Scherer, Nathalie van Uden, Sabrina Pollastro, Nataliya Yeremenko, Monika Hansson, Priscilla F Kerkman, Ellen I H van der Voort, Evan Reed, Hanna Maassen, Mark J Kwakkenbos, Arjen Q Bakker, Lars Klareskog, Vivianne Malmström, Niek de Vries, René E M Toes, Karin Lundberg, Hergen Spits, Dominique L Baeten
OBJECTIVE: Anti-citrullinated protein antibodies (ACPA) are a hallmark for rheumatoid arthritis (RA). Autoantigen-specific B-cell function aside from autoantibody production remains poorly understood in the context of this disease. We set out to elucidate this function through the isolation and immortalization of unique citrullinated protein or peptide (CP)-reactive B-cell clones from RA patients. METHODS: B-cell clones from either blood or synovial fluid of cyclic-citrullinated peptide 2 (CCP2)+ RA patients were immortalized by genetic reprogramming with Bcl6 and Bcl-xL...
October 1, 2018: Arthritis & Rheumatology
N Molano-González, E Olivares-Martínez, J M Anaya, G Hernández-Molina
OBJECTIVE: The presence of anti-citrullinated protein antibodies (ACPAs) in primary Sjögren's syndrome (pSS) ranges from 3% to 9.9%; however, there is no agreement about their clinical significance. Our aim was to systematically review the literature regarding the association of arthritis and ACPAs in pSS and their role in the development of rheumatoid arthritis (RA). METHOD: A comprehensive search of MEDLINE, ISI Web of Knowledge, and Cochrane Library from inception until June 2016 was undertaken using the combination of two or three of the keywords: primary Sjögren's syndrome, Sjögren's syndrome, arthritis, synovitis, arthropathy, anti-cyclic citrullinated peptide antibodies, and anti-citrullinated protein antibody - ACPA...
September 30, 2018: Scandinavian Journal of Rheumatology
T Matsuo, M Hashimoto, I Ito, T Kubo, R Uozumi, M Furu, H Ito, T Fujii, M Tanaka, C Terao, H Kono, M Mori, M Hamaguchi, W Yamamoto, K Ohmura, S Morita, T Mimori
OBJECTIVE: Serum interleukin-18 (IL-18) levels are increased in patients with interstitial lung disease (ILD). In addition, IL-18 levels are increased in patients with rheumatoid arthritis (RA) and are associated with arthritis activity. We determined whether increased IL-18 levels are associated with ILD in RA. METHOD: RA patients were enrolled using an RA cohort database. Plasma IL-18 levels were measured by enzyme-linked immunosorbent assay. ILD was determined by a pulmonologist and a radiologist based on chest radiography and computed tomography findings...
September 30, 2018: Scandinavian Journal of Rheumatology
Meghdad Abdollahpour-Alitappeh, Majid Lotfinia, Nader Bagheri, Koushan Sineh Sepehr, Mahdi Habibi-Anbouhi, Farzad Kobarfard, Saeed Balalaie, Alireza Foroumadi, Ghasem Abbaszadeh-Goudarzi, Kazem Abbaszadeh-Goudarzi, Mohsen Abolhassani
Targeted therapy using specific monoclonal antibodies (mAbs) conjugated to chemotherapeutic agents or toxins has become one of the top priorities in cancer therapy. Antibody-drug conjugates (ADCs) are emerging as a promising strategy for cancer-targeted therapy. In this study, trastuzumab, a humanized monoclonal anti-HER2 antibody, was reduced by dithiothreitol and conjugated to the microtubule-disrupting agent monomethyl auristatin E (MMAE) through a valine-citrulline peptide linker (trastuzumab-MC-Val-Cit-PABC-MMAE [trastuzumab-vcMMAE])...
September 24, 2018: Journal of Cellular Physiology
Hiroshi Furukawa, Shomi Oka, Kota Shimada, Atsushi Hashimoto, Akiko Komiya, Shinichiro Tsunoda, Akiko Suda, Satoshi Ito, Koichiro Saisho, Masao Katayama, Satoshi Shinohara, Takeo Sato, Katsuya Nagatani, Seiji Minota, Toshihiro Matsui, Naoshi Fukui, Shoji Sugii, Hajime Sano, Kiyoshi Migita, Shouhei Nagaoka, Shigeto Tohma
OBJECTIVE: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA) is specifically associated with RA. DRB1 is associated with the susceptibility of RA, especially ACPA-positive RA [ACPA(+)RA]. However, a few studies reported on the independent associations of DPB1 alleles with RA susceptibility. Thus, we investigated the independent association of DPB1 alleles with RA in Japanese populations...
2018: PloS One
Tian-Wei Chen, Yuan Yin, Rui Zhang, Wen-Zhu Ma
OBJECTIVE: To observe the effect of fire-needle acupuncture of "Zusanli" (ST 36) and "Kunlun" (BL 60) on ankle-joint swelling and serum tumor necrosis factor-α (TNF-α) and anti-cyclic citrullinated peptide antibody (ACPA) contents in collagen-induced arthritis (CIA) rats, so as to study its mechanism underlying improvement of rheumatoid arthritis (RA).. METHODS: Thirty-two male Wistar rats were randomized into control, model, medication (Methotrexate) and fire-needling groups ( n =8 in each)...
August 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Yousaf Ali
Patients with a suspected connective tissue disorder should undergo serologic testing to confirm the diagnosis and, in some cases, to monitor disease activity and predict flares. Patients with suspected systemic lupus erythematosus should be tested for antinuclear antibodies. However, antinuclear antibodies are not specific and may be present in many other connective tissue disorders and nonrheumatologic diseases. Thus, patients with suspected systemic lupus erythematosus should undergo further testing to confirm the diagnosis...
August 1, 2018: American Family Physician
Sigita Stropuvienė, Asta Baranauskaitė, Loreta Bukauskienė, Jolanta Zaikauskienė
Background: To provide data on the use of anti-cyclic citrullinated peptide antibody (anti-CCP) and other routinely used clinical parameters and to assess the impact of anti-CCP status on therapeutic decisions, an observational study was conducted in patients with rheumatoid arthritis (RA). Methods: Sixty-seven adult patients with a recent diagnosis of RA were recruited from four rheumatology centres in Lithuania and were prospectively observed for 12 months. Data collection was based on the review of medical records and routine examination of patients...
2018: Acta Medica Lituanica
Ryan Hyde, Martin Runnstrom, Austin Anderson, Leonard Riley, Ali Ataya
A 26 year old female presented for recurrent blood tinged sputum during the previous year with development of frank hemoptysis three days prior to admission. Diffuse alveolar hemorrhage (DAH) was confirmed with serial lavages. The patient had no history of autoimmune disease, vascular thrombosis or pregnancy morbidity including miscarriages or pre-eclampsia. High dose steroids were initiated along with noninvasive ventilatory support. Transthoracic echocardiogram showed severe mitral regurgitation and a vegetation on the mitral valve; transesophageal echocardiogram determined the lesion highly suggestive of Libman-Sachs endocarditis...
2018: Respiratory Medicine Case Reports
Wan Majdiah Wan Mohamad, Soh Ke Jia, Wan Syamimee Wan Ghazali, Haslina Taib
Objectives: Studies have shown that periodontal disease and Rheumatoid Arthritis (RA) shared similar pathogenesis. Anti-Cyclic Citrullinated Peptide anibodies (anti-CCP) has recently been used for diagnosis of RA. Thus, this study aimed to assess the levels of anti-CCP antibodies and periodontal status in RA patients. Methods: Forty four RA patients were included in this study. The blood samples were analysed for anti-CCP levels. Plaque Score (PS), Gingivitis Score (GS), Probing Pocket Depth (PPD) and Clinical Attachment Loss (CAL) were recorded for assessment of periodontal status...
July 2018: Pakistan Journal of Medical Sciences Quarterly
Richard Oluyinka Akintayo, Olufemi Opeyemi Aworinde, Osaze Ojo, Foluke Comfort Akintayo, Olawale Matthias Akinlade, Rasheed Olaide Awodun, Sakiru Oyetunji Isa
OBJECTIVE: Contrary to the old belief that rheumatoid arthritis (RA) is rare in sub-Saharan Africa, recent reports have increasingly recognized that the burden of the disease has probably been long under-appreciated in West Africa. Thus, fertility and other attributes of the reproductive lives among women with RA have not received research attention in Africa. We aimed to compare the fertility between married Nigerian women with and without RA. METHODS: A comparative study of 50 women with RA and 50 women without RA was conducted via the specialist rheumatology clinics at two teaching hospitals in Nigeria...
September 2018: European Journal of Rheumatology
Y Du, J W Wang, M J Zhou, X Y Wu, J Xue, H X Wu
Objective: To investigate the clinical significance of soluble Semaphorin 5A(Sema 5A) in patients of rheumatoid arthritis(RA) and the effect of Sema 5A on osteoclastogenesis in RAW264.7 cells. Methods: (1)Soluble Sema 5A was detected in the serum of 62 RA patients, 30 osteoarthritis(OA) patients and 48 healthy controls(HC) by enzyme-linked immunosorbent assay(ELISA).The relationships between serum Sema 5A and disease activity, radiographic severity and laboratory parameters were investigated in RA patients...
September 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Katarzyna Kolarz, Bożena Targońska-Stępniak, Maria Majdan
Rheumatoid arthritis (RA) is a systemic, autoimmune disease characterized by synovitis and irreversible joint destruction. RA development is a multi-stage process conditioned by the presence of genetic and environmental risk factors on the basis of which systemic immunization develops. The best known genetic factor predisposing to RA development is the polymorphism of HLA-DRB1 region of the major histocompatibility complex. Among environmental factors, importance in the pathogenesis of RA is attributed to the development of inflammation of the respiratory tract and chronic periodontitis caused by Porphyromonas gingivalis...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Hitomi Kobayashi, Yasuyuki Kobayashi, Isamu Yokoe, Noboru Kitamura, Atsuma Nishiwaki, Masami Takei, Jon T Giles
OBJECTIVE: Individuals with rheumatoid arthritis (RA) are at a heightened risk of sudden cardiac death, an outcome increased in those with prolongation of the corrected electrocardiographic QT interval (QTc). We compared QTc between patients with RA and demographically matched controls and studied the change in QTc after treatment with the interleukin 6 inhibitor tocilizumab (TCZ). METHODS: Standard 12-lead electrocardiograms were obtained and QTc was measured in patients with RA at baseline and after 24 weeks of TCZ treatment, then compared with non-RA controls who were frequency-matched on age and sex...
September 1, 2018: Journal of Rheumatology
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