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Exercise induced bradycardia

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https://www.readbyqxmd.com/read/29746848/nitric-oxide-alterations-in-cardiovascular-system-of-rats-with-parkinsonism-induced-by-6-ohda-and-submitted-to-previous-exercise
#1
Lorena de Jager, Eric Diego Turossi Amorim, Bruno Fernando Cruz Lucchetti, Fernanda Novi Cortegoso Lopes, Carlos Cesar Crestani, Phileno Pinge-Filho, Marli Cardoso Martins-Pinge
Studies showed that physical exercise decreases the risk of developing Parkinson's disease (PD) as slowing its progression. During aerobic training, nitric oxide (NO) increases in the substantia nigra pars compacta (SNpc) of individuals with PD. However, no study has evaluated the effects of exercise on peripheral NO levels and its modulatory effects on cardiovascular dysfunctions of subjects with PD. Trained (T) or sedentary (S) animals underwent stereotactic surgery for bilateral 6-hydroxydopamine (6-OHDA) or vehicle microinfusion (Sham group)...
May 7, 2018: Life Sciences
https://www.readbyqxmd.com/read/29434162/bradycardia-is-a-specific-phenotype-of-catecholaminergic-polymorphic-ventricular-tachycardia-induced-by-ryr2-mutations
#2
Kazuaki Miyata, Seiko Ohno, Hideki Itoh, Minoru Horie
Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a lethal inherited disease characterized by ventricular arrhythmias induced by physical exercise or emotional stress. The major cause of CPVT is mutations in RYR2, which encodes the cardiac ryanodine receptor channel. Recent advances in sequencing technology have yielded incidental findings of RYR2 variants in other cardiac diseases. Analyzing the characteristics of RYR2 variants related to CPVT will be useful for differentiation from those related to other cardiac diseases...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29411287/mechanisms-of-atrial-fibrillation-in-athletes-what-we-know-and-what-we-do-not-know
#3
REVIEW
E Guasch, L Mont, M Sitges
Exercise is an emerging cause of atrial fibrillation (AF) in young individuals without coexisting cardiovascular risk factors. The causes of exercise-induced atrial fibrillation remain largely unknown, and conclusions are jeopardised by apparently conflicting data. Some components of the athlete's heart are known to be arrhythmogenic in other settings. Bradycardia, atrial dilatation and, possibly, atrial premature beats are therefore biologically plausible contributors to exercise-induced AF. Challenging findings in an animal model suggest that exercise might also prompt the development of atrial fibrosis, possibly due to cumulative minor structural damage after each exercise bout...
March 2018: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29275944/electrocardiographic-patterns-and-long-term-training-induced-time-changes-in-2484-elite-football-players
#4
Olivier Huttin, Christine Selton-Suty, Clément Venner, Jean-Baptiste Vilain, Pierre Rochecongar, Etienne Aliot
BACKGROUND: High-level physical training induces cardiac structural and functional changes, including 12-lead electrocardiogram modifications. OBJECTIVES: The purpose of this cross-sectional longitudinal study was to establish a quantitative electrocardiographic profile in highly trained football players. Initial and serial annual electrocardiogram monitoring over subsequent years allowed us to investigate the long-term effects of exercise on cardiac conduction and electrophysiological remodelling...
December 21, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29101169/voluntary-apnea-during-dynamic-exercise-activates-the-muscle-metaboreflex-in-humans
#5
Masashi Ichinose, Mayumi Matsumoto, Naoto Fujii, Narumi Yoshitake, Takeshi Nishiyasu
Voluntary apnea during dynamic exercise evokes marked bradycardia, peripheral vasoconstriction, and pressor responses. However, the mechanism(s) underlying the cardiovascular responses seen during apnea in exercising humans is unknown. We therefore tested the hypothesis that the muscle metaboreflex contributes to the apnea-induced pressor response during dynamic exercise. Thirteen healthy subjects participated in apnea and control trials. In both trials, subjects performed a two-legged dynamic knee extension exercise at a workload that elicited heart rates at ~100 beats/min...
March 1, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29097735/mammalian-%C3%AE-2-ampk-regulates-intrinsic-heart-rate
#6
Arash Yavari, Mohamed Bellahcene, Annalisa Bucchi, Syevda Sirenko, Katalin Pinter, Neil Herring, Julia J Jung, Kirill V Tarasov, Emily J Sharpe, Markus Wolfien, Gabor Czibik, Violetta Steeples, Sahar Ghaffari, Chinh Nguyen, Alexander Stockenhuber, Joshua R St Clair, Christian Rimmbach, Yosuke Okamoto, Dongmei Yang, Mingyi Wang, Bruce D Ziman, Jack M Moen, Daniel R Riordon, Christopher Ramirez, Manuel Paina, Joonho Lee, Jing Zhang, Ismayil Ahmet, Michael G Matt, Yelena S Tarasova, Dilair Baban, Natasha Sahgal, Helen Lockstone, Rathi Puliyadi, Joseph de Bono, Owen M Siggs, John Gomes, Hannah Muskett, Mahon L Maguire, Youlia Beglov, Matthew Kelly, Pedro P N Dos Santos, Nicola J Bright, Angela Woods, Katja Gehmlich, Henrik Isackson, Gillian Douglas, David J P Ferguson, Jürgen E Schneider, Andrew Tinker, Olaf Wolkenhauer, Keith M Channon, Richard J Cornall, Eduardo B Sternick, David J Paterson, Charles S Redwood, David Carling, Catherine Proenza, Robert David, Mirko Baruscotti, Dario DiFrancesco, Edward G Lakatta, Hugh Watkins, Houman Ashrafian
AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic AMPK exists as αβγ complexes, whose regulatory γ subunit confers energy sensor function by binding adenine nucleotides. Humans bearing activating mutations in the γ2 subunit exhibit a phenotype including unexplained slowing of heart rate (bradycardia). Here, we show that γ2 AMPK activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower heart rate, including sarcolemmal hyperpolarization-activated current (I f) and ryanodine receptor-derived diastolic local subsarcolemmal Ca(2+) release...
November 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/29093566/hypertension-induces-additional-cardiometabolic-impairments-and-attenuates-aerobic-exercise-training-adaptations-in-fructose-fed-ovariectomized-rats
#7
Janaina de O Brito-Monzani, Iris Callado Sanches, Nathalia Bernardes, Kátia Ponciano, Ivana C Moraes-Silva, Maria-Cláudia Irigoyen, Susana Llesuy, Kátia De Angelis
We tested whether hypertension favors the development of additional cardiometabolic changes in fructose-fed ovariectomized rats and how it affects aerobic exercise training (ET) effects. All rats received fructose in drinking water (10%) beginning at weaning, were ovariectomized at 10 weeks of age and divided into the normotensive sedentary (NFOS) and trained (NFOT) and hypertensive sedentary (HFOS) and trained (HFOT) groups. ET was performed on a treadmill. Arterial pressure (AP) was directly recorded; heart rate and AP variabilities were analyzed...
February 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29079124/laryngocardiac-reflex-a-case-report-and-review-of-the-literature
#8
REVIEW
Christian S Pingree, Jacob S Majors, Nelson S Howard, Robert L Eller
INTRODUCTION: The vagus nerve has sensory and motor function in the larynx, as well as parasympathetic function in the thorax and abdomen. Stimulation of the superior laryngeal nerve can cause reflexive bradycardia. CASE: We describe a case of a 45-year-old man with pre-syncopal symptoms while exercising, and bradycardia found during cardiology workup. Radiography and flexible laryngoscopy showed evidence of a right-sided, vascular laryngeal mass. Exercise testing before and after superior laryngeal nerve block showed reversal of the symptoms with the block...
October 24, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29063953/magnetic-resonance-myocardial-perfusion-imaging-safety-and-indications-in-pediatrics-and-young-adults
#9
David M Biko, R Thomas Collins, Sara L Partington, Matthew Harris, Kevin K Whitehead, Marc S Keller, Mark A Fogel
The purpose of this study was to assess the safety and indications for cardiac magnetic resonance (CMR) with myocardial perfusion imaging (MPI) in a cohort of children and young adults. A retrospective review of 178 children and young adults who underwent CMR with MPI was performed. Studies were categorized based on study protocols as MPI with resting perfusion only, adenosine stress MPI, exercise-induced stress MPI, and MPI for cardiac mass diagnosis. Relevant clinical history, exam indications, and adverse reactions following gadolinium-based contrast agent and adenosine administration were recorded...
February 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29030236/accentuated-vagal-antagonism-paradoxically-increases-ryanodine-receptor-calcium-leak-in-long-term-exercised-calsequestrin2-knockout-mice
#10
Hsiang-Ting Ho, Senthil Thambidorai, Björn C Knollmann, George E Billman, Sandor Györke, Anuradha Kalyanasundaram
BACKGROUND: Long-term aerobic exercise alters autonomic balance, which may not be favorable in heart rate (HR)-dependent arrhythmic diseases including catecholaminergic polymorphic ventricular tachycardia (CPVT) because of preexisting bradycardia and increased sensitivity to parasympathetic stimulation. OBJECTIVE: The purpose of this study was to determine whether long-term exercise-induced autonomic adaptations modify CPVT susceptibility. METHODS: We determined exercise-induced parasympathetic effects on HR, arrhythmia incidence, and intracellular sarcoplasmic reticulum (SR) Ca2+ leak in atrial (ACM) and ventricular (VCM) cardiomyocytes, in exercised (EX) calsequestrin knockout (CASQ2-/- ) mice, a model of CPVT...
March 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28964689/exercise-training-improves-hypertension-induced-autonomic-dysfunction-without-influencing-properties-of-peripheral-cardiac-vagus-nerve
#11
Octávio Barbosa Neto, Carla Cristina de Sordi, Gustavo Ribeiro da Mota, Moacir Marocolo, Rosângela Soares Chriguer, Valdo José Dias da Silva
We examined the vagal transfer function of autonomic heart rate (HR) control in anesthetized sedentary and exercise-trained Spontaneously Hypertensive Rats (SHR). To this end, male SHR and Wystar-Kyoto (WKY) rats with 48-50weeks of age-old were divided into 4 groups: sedentary (SHRS , n=12) and trained (SHRT , n=14) hypertensive rats, sedentary (WKYS , n=13) and trained (WKYT , n=13) normotensive rats. The trained groups were submitted to swimming protocol for 9weeks. Blood pressure (BP), HR, HR variability (HRV), BP variability (BPV), baroreflex sensitivity and cardiac tonus were recorded in baseline conditions...
December 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28821541/targeting-mir-423-5p-reverses-exercise-training-induced-hcn4-channel-remodeling-and-sinus-bradycardia
#12
Alicia D'Souza, Charles M Pearman, Yanwen Wang, Shu Nakao, Sunil Jit R J Logantha, Charlotte Cox, Hayley Bennett, Yu Zhang, Anne Berit Johnsen, Nora Linscheid, Pi Camilla Poulsen, Jonathan Elliott, Jessica Coulson, Jamie McPhee, Abigail Robertson, Paula A da Costa Martins, Ashraf Kitmitto, Ulrik Wisløff, Elizabeth J Cartwright, Oliver Monfredi, Alicia Lundby, Halina Dobrzynski, Delvac Oceandy, Gwilym M Morris, Mark R Boyett
RATIONALE: Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic current, If, underlies exercise training-induced sinus bradycardia in rodents. If this occurs in humans, it could explain the increased incidence of bradyarrhythmias in veteran athletes, and it will be important to understand the underlying processes. OBJECTIVE: To test the role of HCN4 in the training-induced bradycardia in human athletes and investigate the role of microRNAs (miRs) in the repression of HCN4...
October 13, 2017: Circulation Research
https://www.readbyqxmd.com/read/28684594/counterpoint-exercise-training-induced-bradycardia-the-case-for-enhanced-parasympathetic-regulation
#13
George E Billman
No abstract text is available yet for this article.
September 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28684593/point-exercise-training-induced-bradycardia-is-caused-by-changes-in-intrinsic-sinus-node-function
#14
Mark R Boyett, Yanwen Wang, Shu Nakao, Jonathan Ariyaratnam, George Hart, Oliver Monfredi, Alicia D'Souza
No abstract text is available yet for this article.
September 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28385917/exercise-training-induced-bradycardia-is-caused-by-changes-in-intrinsic-sinus-node-function
#15
Mark R Boyett, Yanwen Wang, Shu Nakao, Jonathan Ariyaratnam, George Hart, Oliver Monfredi, Alicia D'Souza, George E Billman
No abstract text is available yet for this article.
April 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27830772/diagnosis-pathophysiology-and-management-of-exercise-induced-arrhythmias
#16
REVIEW
Eduard Guasch, Lluís Mont
The cardiovascular benefits of physical activity are indisputable. Nevertheless, growing evidence suggests that both atrial fibrillation and right ventricular arrhythmia can be caused by intense exercise in some individuals. Exercise-induced atrial fibrillation is most commonly diagnosed in middle-aged, otherwise healthy men who have been engaged in endurance training for >10 years, and is mediated by atrial dilatation, parasympathetic enhancement, and possibly atrial fibrosis. Cardiac ablation is evolving as a first-line tool for athletes with exercise-induced arrhythmia who are eager to remain active...
February 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27787741/lifetime-regular-exercise-affects-the-incident-of-different-arrhythmias-and-improves-organismal-health-in-aging-female-drosophila-melanogaster
#17
Lan Zheng, Qiu Fang Li, Liu Ni, Hui Wang, Xiang Cheng Ruan, Xiu Shan Wu
We used Drosophila melanogaster as an animal model system to study the impact of exercise training initiated early in life on cardiac function using a well-established model of inherent myogenic properties of the heart and discussed the changes on myosin, a myocardial contractile protein. We also explored the effect of early physical exercise on organismal aging by analyzing the wake-sleep pattern using a Drosophila activity monitor system. We found that a variety of arrhythmias are part of the heart spectrum in old flies after a lifetime of physical exercise as evidenced by reducing the incidence of fibrillations and increasing the occurrence of bradycardias...
February 2017: Biogerontology
https://www.readbyqxmd.com/read/27774647/bile-acid-excess-induces-cardiomyopathy-and-metabolic-dysfunctions-in-the-heart
#18
Moreshwar S Desai, Bhoomika Mathur, Zeena Eblimit, Hernan Vasquez, Heinrich Taegtmeyer, Saul J Karpen, Daniel J Penny, David D Moore, Sayeepriyadarshini Anakk
Cardiac dysfunction in patients with liver cirrhosis is strongly associated with increased serum bile acid concentrations. Here we show that excess bile acids decrease fatty acid oxidation in cardiomyocytes and can cause heart dysfunction, a cardiac syndrome that we term cholecardia. Farnesoid X receptor; Small Heterodimer Partner double knockout mice, a model for bile acid overload, display cardiac hypertrophy, bradycardia, and exercise intolerance. In addition, double knockout mice exhibit an impaired cardiac response to catecholamine challenge...
January 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27539163/catecholaminergic-polymorphic-ventricular-tachycardia-associated-with-sinus-node-dysfunction-and-junctional-rhythm-case-report-and-literature-review
#19
REVIEW
Natale Daniele Brunetti, Pier Luigi Pellegrino, Girolamo D'Arienzo, Rafel Sai, Luigi Ziccardi, Francesco Santoro, Antonio Gaglione, Matteo Di Biase
We report the case of a 38-year-old woman with history of syncope and polymorphic ventricular tachycardia; tachycardia was inducible at exercise stress test, not at electrophysiologic study. Phases of QT prolongation were found at ambulatory electrocardiogram monitoring. The woman came to our attention for periodic control of implantable loop recorder. Rest electrocardiogram at admission unexpectedly showed sinus bradycardia, junctional rhythm, and ventricular premature beats. Furthermore, loop recorder control revealed a short run of bidirectional tachycardia, not associated with syncope...
November 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27313537/ca-2-clock-dependent-pacemaking-in-the-sinus-node-is-impaired-in-mice-with-a-cardiac-specific-reduction-in-serca2-abundance
#20
Sunil Jit R J Logantha, Mathis K Stokke, Andrew J Atkinson, Sanjay R Kharche, Sajida Parveen, Yawer Saeed, Ivar Sjaastad, Ole M Sejersted, Halina Dobrzynski
BACKGROUND: The sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2) pump is an important component of the Ca(2+)-clock pacemaker mechanism that provides robustness and flexibility to sinus node pacemaking. We have developed transgenic mice with reduced cardiac SERCA2 abundance (Serca2 KO) as a model for investigating SERCA2's role in sinus node pacemaking. METHODS AND RESULTS: In Serca2 KO mice, ventricular SERCA2a protein content measured by Western blotting was 75% (P < 0...
2016: Frontiers in Physiology
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