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Near Infrared Therapy

Xiaoxia Wu, Jing Liu, Lingyan Yang, Fu Wang
Chemotherapy is an important first-line strategy for tumor therapy in cancer treatment, but multidrug resistance (MDR) is a major problem that reduces the efficacy of chemotherapeutics. Herein, we report a novel photothermally controlled intelligent drug release system (AuNP@mSiO2 -DOX-FA) with a large amount of drugs loading for synergistic chemo-photothermal therapy of MDR in breast cancer. The nanoplatform utilized gold nanoparticles as a hyperthermia core, and large-mesoporous silica as a shell for doxorubicin (DOX) loading...
December 5, 2018: Colloids and Surfaces. B, Biointerfaces
Dan Wang, Yuwen Zhang, Qi Guo
Background: Facile synthesis and small size theranostic agents have shown great potential for cancer diagnosis and treatment. Purpose: A ternary compound (Cu5 FeS4 ), Fe doped copper sulfide, with novel magnetic properties and strong near-infrared absorption was prepared for magnetic resonance imaging (MRI) imaging guided photothermal therapy of cancer. Patients and methods: Firstly, the capability of magnetic resonance imaging based on the novel magnetic properties and the photothermal performance due to the strong near-infrared absorption was investigated in vitro...
2018: International Journal of Nanomedicine
Zhao Liu, Jia Zhang, Yuhang Tian, Lei Zhang, Xue Han, Qiucheng Wang, Wen Cheng
Ultrasound molecular imaging as a promising strategy, which involved the use of molecularly targeted contrast agents, combined the advantages of contrast-enhanced ultrasound with the photothermal effect of reduced graphene oxide (rGO). Methods and results: The heparin sulfate proteoglycan glypican-3 (GPC3) is a potential molecular target for hepatocellular carcinoma (HCC). In this study, we covalently linked biotinylated GPC3 antibody to PEGylated nano-rGO to obtain GPC3-modified rGO-PEG (rGO-GPC3), and then combined rGO-GPC3 with avidinylated nanobubbles (NBs) using biotin-avidin system to prepare NBs-GPC3-rGO with photothermal effect and dispersibility, solubility in physiological environment...
2018: International Journal of Nanomedicine
Ying Wang, Ke Zheng, Guangshan Xuan, Mingdong Huang, Jinping Xue
Purpose: Zinc phthalocyanine (ZnPc) has been applied widely in photodynamic therapy (PDT) with high ROS-production capacity and intense absorption in the near-infrared region. However, weak tumor targeting and the aggregation tendency of ZnPc seriously affect the therapeutic effect of PDT. Therefore, overcoming the aggregation of ZnPc and enhancing its antitumor effect were the purpose of this study. Methods: In this study, we first found that the aggregation behaviors of the photosensitizer ZnPc(TAP)4 , ZnPc substituted by tertiary amine groups, were regulated finely by pH and that ZnPc(TAP)4 could be disaggregated gradually as the pH descended...
2018: International Journal of Nanomedicine
Xinhui Xie, Jialei Song, Yili Hu, Suyang Zhuang, Yuntao Wang, Yunlei Zhao, Qian Lu
Background: Development of the burgeoning number of photothermal therapy (PTT) agents has drawn a huge amount of interest, since PTT treatment is a powerful and effective alternative to traditional treatments. Optimal PTT agents should integrate some essential preconditions including negligible systemic toxicity, deep penetration into tumor tissues, and maximum laser energy absorbance. Unfortunately, only few of the PTT agents reported could meet all of the above mentioned conditions...
2018: International Journal of Nanomedicine
Qian Li, Lihong Sun, Mengmeng Hou, Qiubing Chen, Ruihao Yang, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Environmental stimuli, including pH, light and temperature, have been utilized for activating controlled drug delivery to achieve efficient antitumor therapeutics while minimizing undesirable side effects. In this study, a multifunctional nanoplatform based on hollow mesoporous copper sulfide nanoparticles (H-CuS NPs) was developed by loading the interior cavity of the NPs with a drug-loaded phase change material (PCM, 1-tetradecanol). Doxorubicin (DOX) and chlorin e6 (Ce6) were selected as the model chemotherapeutic drug and photosensitizer, respectively, which were encapsulated in H-CuS NPs via the PCM to form H-CuS@PCM/DOX/Ce6 (HPDC) NPs...
December 12, 2018: ACS Applied Materials & Interfaces
Hyoryong Lee, Hyunchul Choi, Mikyoung Lee, Sukho Park
Currently, microrobots are receiving attention because of their small size and motility, which can be applied to minimal invasive therapy. Additionally, various microrobots using hydrogel with the characteristics of biocompatibility and biodegradability are also being developed. Among them, microrobots that swell and deswell in response to temperature changes caused by external near infrared (NIR) stimuli, focused ultrasound, and an alternating magnetic field, have been receiving a great amount of interest as drug carriers for therapeutic cell delivery...
November 16, 2018: Biomedical Microdevices
Shikai Liu, Wenting Li, Shili Gai, Guixin Yang, Chongna Zhong, Yunlu Dai, Fei He, Piaoping Yang, Yung Doug Suh
Near-infrared (NIR) light-induced imaging-guided cancer therapy has been studied extensively in recent years. Herein, we report a novel theranostic nanoplatform by modifying polyoxometalate (POM) nanoclusters onto mesoporous silica-coated upconversion nanoparticles (UCNPs), followed by loading doxorubicin (DOX) in the mesopores and coating a folate-chitosan shell onto the surface. In this nanoplatform, the core-shell structured UCNPs (NaYF4:Yb,Er@NaYF4:Yb,Nd) showed special upconverting luminescence (UCL) when irradiated with high-penetration 808 nm NIR light, and the doped Yb and Nd ions endowed the sample with CT imaging properties, thus achieving a dual-mode imaging function...
December 10, 2018: Biomaterials Science
Bo Huang, Lei Tan, Xiangmei Liu, Jun Li, Shuilin Wu
Bone-implant materials are important for bone repairing and orthopedics surgery, which include bone plates and bone nails. These materials need to be designed not only considering its biostability and biocompatibility, but also their by-products induced infection after therapy or long-time treatment in vivo . Thus, the development of novel implant materials is quite urgent. Red phosphorus has great biocompatibility and exhibits efficient photothermal ability. Herein, a red phosphorus/IR780/arginine-glycine-asparticacid-cysteine (RGDC) coating on titanium bone-implant was prepared...
March 2019: Bioactive Materials
Imad Khan, Mehboob Rehan, Gunjan Parikh, Christopher Zammit, Neeraj Badjatia, Daniel Herr, Zachary Kon, Charles Hogue, Michael Mazzeffi
Background: Regional cerebral oxygen saturation (rScO2) measured by near-infrared spectroscopy (NIRS) can be used to monitor brain oxygenation in extracorporeal membrane oxygenation (ECMO). ECMO patients that develop acute brain injuries (ABIs) are observed to have worse outcomes. We evaluated the association between rScO2 and ABI in venoarterial (VA) ECMO patients. Methods: We retrospectively reviewed prospectively-collected NIRS data from patients undergoing VA ECMO from April 2016 to October 2016. Baseline demographics, ECMO and clinical characteristics, cerebral oximetry data, neuroradiographic images, and functional outcomes were reviewed for each patient...
2018: Frontiers in Neurology
Klaus Müllen, Chang Liu, Shaobo Zhang, Jianhao Li, Jie Wei, Meizhen Yin
Precision phototheranostics, including photoacoustic imaging and photothermal therapy, requires stable photothermal agents. Developing photothermal agents with high stability and high photothermal conversion efficiency (PTCE) remains a considerable challenge in biomedical applications. Herein, we introduce a new photothermal agent based on water-soluble quaterrylenediimide (QDI) that can self-assemble into nanoparticles (QDI-NPs) in aqueous solution. Incorporation of polyethylene glycol (PEG) into the QDI core significantly enhances both physiological stability and biocompatibility of QDI-NPs...
December 7, 2018: Angewandte Chemie
Jason L Raymond, Robin O Cleveland, Ronald A Roy
The optical properties of tissue change during thermal ablation. Multi-modal methods such as acousto-optic (AO) and photo-acoustic (PA) imaging may provide a real-time, direct measure of lesion formation. Baseline changes in optical properties have been previously measured over limited ranges of thermal dose for tissues exposed to a temperature-controlled water bath, however, there is scant data for optical properties of lesions created by HIFU. In this work, the optical scattering and absorption coefficients from 400-1300 nm of excised chicken breast exposed to HIFU were measured using an integrating sphere spectrophotometric technique...
December 7, 2018: Physics in Medicine and Biology
Xunzhou Yu, Danfeng He, Ximu Zhang, Hongmei Zhang, Jinlin Song, DeZhi Shi, Yahan Fan, Gaoxing Luo, Jun Deng
Since generating toxic reactive oxygen (ROS) is largely dependent on oxygen, bacteria infected wounds hypoxia significantly inhibits photodynamic therapy's (PDT) antibacterial efficiency. Therefore, a novel therapeutic method for eradicating multidrug-resistant bacteria is developed based on the light-activated alkyl free radical generation (that is oxygen-independent). According to the polydopamine coated carboxyl graphene (PDA@CG), an initiator-loaded and pH-sensitive heat-producible hybrid of bactericides was synthesized...
December 7, 2018: ACS Applied Materials & Interfaces
Shou-Yuan Sung, Yu-Lin Su, Wei Cheng, Pei-Feng Hu, Chi-Shiun Chiang, Wen-Ting Chen, Shang-Hsiu Hu
Dual targeted delivery of drugs and energy by nanohybrids can potentially alleviate side effects and improve the unique features required for precision medicine. To realize this aim, however, the hybrids which are often rapidly removal from circulation and piled up tumors periphery near the blood vessels must address the difficulties in low blood half-lives and tumor penetration. In this study, a sponge-inspired carbon composites-supported red blood cell (RBC) membrane that doubles as a stealth agent and photolytic carrier that transports tumor-penetrative agents (graphene quantum dots and docetaxel (GQD-D)) and heat with irradiation was developed...
December 6, 2018: Nano Letters
Ziming Zheng, Hongjuan Li, Shiguo Sun, Yongqian Xu
Abnormal level of proteins is proved to be associated with diseases. Thus, protein sensing is helpful for clinical diagnosis and therapy. However, there is a great variety of protein species and relatively low concentration of each protein in complicated biological systems including other non-protein biomolecules. Therefore, it remains challenging to develop an effective method for detecting protein with high selectivity and sensitivity. Herein, a new self-assembly method based on a robust dye SQSS of which two squaraine molecules were conjugated through disulfide bond was developed for highly selective and sensitive detection of serum albumin (SA) in aqueous solution and live cells...
December 4, 2018: ACS Applied Materials & Interfaces
Song Chai, Shifeng Kan, Ran Sun, Ruijuan Zhou, Yi Sun, Wenhua Chen, Bo Yu
Background: Integration of several types of therapeutic agents into one nanoplatform to enhance treatment efficacy is being more widely used for cancer therapy. Methods: Herein, a biocompatible polydopamine (PDA)-coated MoSe2 -wrapped doxorubicin (DOX)-loaded hollow mesoporous silica nanoparticles (HMSNs) nanoplatform (PM@HMSNs-DOX) was fabricated for dual-sensitive drug release and chemo-photothermal therapy for enhancing the therapeutic effects on breast cancer...
2018: International Journal of Nanomedicine
Bin Li, Zhongyin Jiang, Diya Xie, Yiqing Wang, Xingzhen Lao
Background: Photothermal therapy (PTT) has received extensive attention owing to its non-invasive nature and highly therapeutic outcomes. PTT agents and near-infrared (NIR) laser are essential elements in PTT. However, most PTT agents are composed of heavy metals, characterized by serious cytotoxicity and side effects, and NIR irradiation often damages normal tissue owing to the high dose, thus limiting the clinical application of PTT. Purpose: In this regard, exploring new perspectives enabling more PTT agents to be enriched into the tumor and NIR laser irradiation decay in PTT is vital...
2018: International Journal of Nanomedicine
Chao Zhang, Deng-Feng Hu, Jing-Wei Xu, Meng-Qi Ma, Huabin Xing, Ke Yao, Jian Ji, Zhi-Kang Xu
Transition metal dichalcogenides (TMDs) nanosheets have evoked enormous research enthusiasm and have shown increased potentials in biomedical field. However, a great challenge lies in high-throughput, large-scale and eco-friendly preparation of TMDs nanosheets dispersions with high quality. Herein, we report a universal polyphenol-assisted strategy to facilely exfoliate various TMDs into monolayer or few-layer nanosheets. By optimizing the exfoliation condition of molybdenum disulfide (MoS2), the yield and concentration of as-exfoliated nanosheets is up to 60...
December 3, 2018: ACS Nano
Yunjian Xu, Menglong Zhao, Liang Zou, Licai Wu, Mingjuan Xie, Tianshe Yang, Shujuan Liu, Wei Huang, Qiang Zhao
Phototherapy, as an important class of noninvasive tumor treatment methods, has attracted extensive research interest. Although a large amount of the near-infrared (NIR) phototherapeutic agents have been reported, the low efficiency, complicated structures, tedious synthetic procedures, and poor photostability limit their practical applications. To solve these problems, herein, a donor-acceptor-donor (D-A-D) type organic phototherapeutic agent (B-3) based on NIR aza-boron-dipyrromethene (aza-BODIPY) dye has been constructed, which shows the enhanced photothermal conversion efficiency and high singlet oxygen generation ability by simultaneously utilizing intramolecular photoinduced electron transfer (IPET) mechanism and heavy atom effects...
December 3, 2018: ACS Applied Materials & Interfaces
Longguang Tang, Xiaoli Sun, Nian Liu, Zijian Zhou, Fei Yu, Xianzhong Zhang, Xiaolian Sun, Xiaoyuan Chen
To meet the criteria of effective theranostics, biocompatible nanomedicine endowing intrinsic therapeutic and imaging properties have gained extraordinary momentum. In this study, an ultra-stable near-infrared (NIR) dye croconaine (CR780) was engineered with arginine-glycine-aspartic acid (RGD) peptide and polyethylene glycol (PEG), which was then self-assembled into uniform nanoparticles (NPs). These RGD-CR780-PEG5K assemblies were radiolabeled with 125 I through a facile standard Iodo-Gen method. The resulting [125 I]RGD-CR780-PEG5K NPs showed effective accumulation in αv β3 integrin expressing glioblastoma, as evidenced by single photon emission computed tomography (SPECT)/CT and NIR fluorescence imaging...
April 27, 2018: ACS applied nano materials
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