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Near Infrared Therapy

Yue Wu, Moustafa R K Ali, Bin Dong, Tiegang Han, Kuangcai Chen, Jin Chen, Yan Tang, Ning Fang, Fangjun Wang, Mostafa A El-Sayed
Most cancer-related deaths come from metastasis. It was recently discovered that nanoparticles could inhibit cancer cell migration. While most researchers focus on single-cell migration, the effect of nanoparticle treatment on collective cell migration has not been explored. Collective migration occurs commonly in many types of cancer metastasis, where a group of cancer cells move together, which requires the contractility of the cytoskeleton filaments and the connection of neighboring cells by the cell junction proteins...
August 17, 2018: ACS Nano
Di Zhang, Jing Zhang, Qian Li, Hailong Tian, Na Zhang, Zhonghao Li, Yuxia Luan
The short lifetime and easily quick elimination of near-infrared dye new indocyanine green (IR820) in body restrict its practical application as photothermal agent in cancer therapy. Meanwhile, the drawback of poor water solubility of chemotherapeutic drug paclitaxel (PTX) largely restricts its clinical applications. Herein we for the first time combined IR820 and PTX in an "all-in-one" fluorescence imaging-guided chemo-photothermal therapy platform by rational design of a novel pH- and enzyme-sensitive IR820-PTX conjugate assembly...
August 17, 2018: ACS Applied Materials & Interfaces
Anyanee Kamkaew, Feng Li, Zheng Li, Kevin Burgess
Tropomyosin receptor kinases receptor C is expressed at high levels on the surface of tumors from metastatic breast cancer, metastatic melanoma, glioblastoma, and neuroblastoma. Previous studies have shown synthetic TrkC ligands bearing agents for photodynamic therapy could be used to completely ablate 4T1 metastatic breast tumors and suppress metastatic spread in vivo . Modification of these probes ( A in the text) to make them suitable for near infrared optical imaging in vivo would require a substantial increase in molecular mass (and hence increased vulnerability to undesirable absorption, metabolism and immunogenicity effects), or significant changes to the probe design which might compromise binding to TrkC in histochemical studies and on live cells...
October 1, 2017: MedChemComm
Xin Wu, Hui Li, Ning Xiao
Medication obstruction of microscopic organisms has turned into a worldwide medical issue, as it makes the ordinary anti-toxins less effective. It is desperately expected to investigate novel antibacterial materials and create viable treatment techniques to defeat the medication obstruction of anti-infection agents. Herein, we effectively fabricated silver nanoparticles improved proline/graphene oxide nano-flakes (GO-Pro/n-Ag) as novel anti-pathogenic substance through simplistic technique. The property of the silver nanoparticles activated discharge gave amazing antibacterial and antifungal movement against the pathogenic microorganism...
July 18, 2018: Journal of Photochemistry and Photobiology. B, Biology
Yao Lu, Lihua Li, Zefeng Lin, Mei Li, Xiaoming Hu, Yu Zhang, Mingying Peng, Hong Xia, Gang Han
Despite its 5-year event-free survival rate increasing to 60-65% due to surgery and chemotherapy, osteosarcoma (OS) remains one of the most threatening malignant human tumors, especially in young patients. Therefore, a new approach that combines early diagnosis with efficient tumor eradication and bioimaging is urgently needed. Here, a new type of mesoporous silica-coated bismuth sulfide nanoparticles (Bi2 S3 @MSN NPs) is developed. The well distributed mesoporous pores and large surface areas hold great promise for drug protection and encapsulation (doxorubicin (DOX), 99...
August 13, 2018: Advanced Healthcare Materials
Hongrui Zhu, Dui Qin, Youshen Wu, Bowen Jing, Jiajun Liu, David Hazlewood, Hongmei Clara Zhang, Yi Feng, Xinmai Yang, Mingxi Wan, Daocheng Wu
Laser-activated bioprobes with high photothermal conversion efficiency (IRPDA@PFH NDs) based on biocompatible IR-780 doped polydopamine perfluorocarbon nanodroplets were developed. When protected by gelatin microspheres, their near-spherical morphologies can be easily observed with transmission electron microscope. Doping IR-780 (3% w/w of added dopamine hydrochloride) could significantly enhance near-infrared (NIR) absorption and photothermal conversion efficiency to 57.7%. The enhanced NIR absorption and non-radiative relaxation are preferred to stronger photoacoustic (PA) signals and higher PA imaging definition, ultrasound (US) signals also increase more than 2...
August 13, 2018: ACS Applied Materials & Interfaces
Justin Hudak, David Rosenbaum, Beatrix Barth, Andreas J Fallgatter, Ann-Christine Ehlis
Neurofeedback (NF) is a form of behavioral therapy used to treat e.g. attention-deficit/hyperactivity disorder (ADHD). Briefly, subjects are fed-back a putatively dysfunctional parameter of their brain activity in real time and must learn to control it in a suggested direction. NF protocols for ADHD have been used in practice for decades, though no clear standards on NF design have been implemented. Furthermore, studies often present only data from the general outcome of the NF treatment and do not look at how exactly the NF paradigm affects brain functionality, or what exactly the NF is training...
2018: PloS One
Mingjun Xuan, Jingxin Shao, Changyong Gao, Wei Wang, Luru Dai, Qiang He
We report a near-infrared (NIR) light-powered Janus mesoporous silica nanomotor (JMSNM) with macrophage cell membrane (MPCM) cloaking that can actively seek cancer cells and thermomechanically percolate cell membrane. Upon exposure to NIR light, a heat gradient across the Janus boundary of the JMSNMs is generated by the photothermal effect of the Au half-shells, resulting in a self-thermophoretic force that propels the JMSNMs. In biological media, the MPCM camouflaging can not only prevent dissociative biological blocks from adhering to JMSNMs but also improve the seeking sensitivity of the nanomotors by specifically recognizing cancer cells...
August 9, 2018: Angewandte Chemie
Lei Zhang, Lihong Sun, Mengmeng Hou, Zhigang Xu, Yuejun Kang, Peng Xue
Temperature is a critical extrinsic physical parameter that determines cell fate. Hyperthermia therapy has become an efficient treatment for tumor ablation. To understand the response of tumor cells under thermal shocks, we present a paper-based photothermal array that can be conveniently coupled with commercial 96-well cell culture plates. This paper chip device was fabricated in one step using Parafilm® and Kimwipers® based on a heat lamination strategy. Liquid was completely adsorbed and confined within the cellulose fibres of hydrophilic regions...
August 9, 2018: Biomedical Microdevices
Eva Achbergerová, Daniela Šmejkalová, Gloria Huerta-Angeles, Karel Souček, Martina Hermannová, Hana Vágnerová, Robert Vícha, Vladimír Velebný
Development of delivery systems which allow real-time visual inspection of tumors is critical for effective therapy. Near-infrared (NIR) fluorophores have a great potential for such an application. To overcome NIR dyes short blood circulation time and increase tumor accumulation, a NIR dye, cypate, was associated with oleyl hyaluronan, which can self-assemble into polymeric aggregates. The cypate association with oleyl hyaluronan was performed either by a covalent linkage, or physical entrapment. The two systems were compared for tumor targeting and contrast enhancement using BALB/c mice bearing 4T1 breast cancer tumors...
October 15, 2018: Carbohydrate Polymers
Bingqing Liu, Susan Monro, Levi Lystrom, Colin G Cameron, Katsuya Colón, Huimin Yin, Svetlana Kilina, Sherri A McFarland, Wenfang Sun
A series of cationic dinuclear iridium(III) complexes (Ir1-Ir5) bearing terpyridine-capped fluorenyl bridging ligands and different polypyridyl or cyclometalating terminal tridentate ligands were synthesized, characterized, and evaluated for their photophysical and photobiological activities. The influence of the bridging and terminal ligands on the photophysical properties of the complexes was investigated by UV-vis absorption, emission, and transient absorption spectroscopy and simulated by TDDFT calculations...
August 9, 2018: Inorganic Chemistry
Qing-Lan Li, Yao Sun, Li Ren, Xin Wang, Chen Wang, Lin Li, Ying-Wei Yang, Xianghui Yu, Jihong Yu
A smart supramolecular nanosystem integrating targeting, chemotherapy and photothermal therapy, was constructed based on carboxylatopillar[5]arene (CP[5]A)-functionalized CuS nanoparticles (CuS@CP NPs). CuS@CP NPs with good monodispersibility and strong near-infrared absorption were synthesized in aqueous solution through a facile one-pot supramolecular capping method, followed by surface installation of a liver cancer-targeted galactose derivative through host-guest binding interaction. The resulting smart supramolecular nanosystem, namely CuS@CPG, exhibited excellent photothermal ablation capability to HepG2 cells upon irradiation with laser at 808 nm...
August 9, 2018: ACS Applied Materials & Interfaces
Jing Bai, Xiaodan Jia, Yudi Ruan, Chao Wang, Xiue Jiang
Phototherapy, including photothermal therapy (PTT)/photodynamic therapy (PDT), is usually considered as a promising strategy for cancer treatment due to its noninvasive and selective therapeutic effect by laser irradiation. A light-activatable nanoplatform based on bovine serum albumin (BSA)-coated Bi2 Te3 nanosheets conjugated with methylene blue (MB) was successfully designed and constructed for bimodal PTT/PDT combination therapy. The resultant nanoconstruct (BSA-Bi2 Te3 /MB) exhibited high stability in various physiological solutions and excellent biocompatibility...
August 8, 2018: Inorganic Chemistry
Luke Henderson, Oara Neumann, Caterina Kaffes, Runmin Zhang, Valeria Marangoni, Murali K Ravoori, Vikas Kundra, James Bankson, Peter Nordlander, Naomi J Halas
Engineering a compact, near-infrared plasmonic nanostructure with integrated image-enhancing agents for combined imaging and therapy is an important nanomedical challenge. Recently we showed that Au@Si@Au nanomatryoshkas (NM) are a highly promising nanostructure for hosting either T1 MRI or fluorescent contrast agents with a photothermal therapeutic response in a compact geometry. Here we show that a near-infrared-resonant NM can provide simultaneous contrast enhancement for both T1 magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) by encapsulating both types of contrast agents in the internal silica layer between the Au core and shell...
August 8, 2018: ACS Nano
Xi Yang, Bo Fan, Wei Gao, Liping Li, Tingting Li, Jinghua Sun, Xiaoyang Peng, Xiaoyan Li, Zhenjun Wang, Binquan Wang, Ruiping Zhang, Jun Xie
Background: Effective endosomal escape is still a critical bottleneck for intracellular delivery of small interfering RNAs (siRNAs) to maximize their therapeutic efficacy. To overcome this obstacle, we have developed a photothermally triggered system by using the near-infrared (NIR) irradiation to achieve "on-demand" endosomal escape and subsequent siRNA release into cytoplasm. Materials and methods: Herein, the poly-L-lysine (PLL) was successfully conjugated with melanin to obtain melanin-poly-L-lysine (M-PLL) polymer as a siRNA vehicle...
2018: International Journal of Nanomedicine
Jie Sheng, Beibei Ma, Qian Yang, Chao Zhang, Zhongying Jiang, Entomack Borrathybay
Introduction: In recent years, near-infrared laser-induced photothermal therapy is being considered as a promising approach to kill tumors owing to its noninvasive nature and excellent antitumor efficiency. However, the lack of ideal photothermal agents hinders further development of this technology. Materials and methods: Aiming at solving this long-standing obstacle, we report here about the polyethylene glycol (PEG)-DA modified copper sulfide (CuS) nanoparticles (NPs) (PEG-DA-CuS NPs), a kind of semiconductor photothermal agents that show excellent photothermal stability and high heat conversion efficiency...
2018: International Journal of Nanomedicine
Sheng Wang, Zijian Zhou, Guocan Yu, Nan Lu, Yijing Liu, Yunlu Dai, Xiao Fu, Jing Wang, Xiaoyuan Chen
Accurate diagnosis of tumor is promising to guide photothermal therapy (PTT) for efficacious tumor ablation with minimal damage to healthy tissues. Here we report an activatable dual-modal imaging agent which is based on PEGylated- gadolinium metallofullerene- polypyrrole nanoparticle (PEG-GMF-PPy NP) for imaging-guided PTT. A contrast agent (gadolinium metallofullerene, GMF) with excellent magnetic resonance imaging (MRI) performance and an ultra pH-responsive polymer (PEG-PC7A) are successively modified to the surface of photothermal agent (PPy NP)...
August 7, 2018: ACS Applied Materials & Interfaces
Ke Jiang, Haoran Wang, Huanhuan Zhang, Yiqiao Hu, Jinhui Wu
Near-Infrared (NIR) dyes, with improved tissue penetration, minimal invasiveness and high specificity, have gained great interests in diagnosing and treating tumors. However, the poor solubility in aqueous medium and low 1O2 quantum yields of NIR dyes restrict their application in PDT (photodynamic therapy) research. Herein, a novel nanosystem with modifying the NIR dyes and encapsulating perfluorocarbon is reported for improving the PDT effectiveness of NIR dyes. By adding the PEG2000-SH and the C13 carbon chain to a NIR representative dye IR780, the new formed material PEG-IR780-C13 shows good solubility in water...
July 30, 2018: Cellular and Molecular Biology
Kyoung-Suk Moon, Young-Bum Park, Ji-Myung Bae, Seunghan Oh
The infection control of implants is one of the hot issues in the field of medicine and dentistry. In this study, we prepared gold nanorod-sputtered titania nanotubes on titanium surface, which is the main component of implant material, and aimed to estimate the remote-controlled tetracycline release and resulting antibacterial effects of gold nanorod-sputtered titania nanotubes using near-infrared laser irradiation. Gold nanorods prepared by ion plasma sputtering (aspect ratio = 1:3) showed optical properties like those of chemically synthesized gold nanorods, exhibiting photothermal effects in the near-infrared region, as demonstrated using field-emission scanning electron microscopy, transmission electron microscopy, and diffuse ultraviolet-visible-near-infrared spectrophotometry...
January 2018: Journal of Tissue Engineering
Xiao Zheng, Fan Zhang, Yawei Zhao, Jing Zhang, Jianati Dawulieti, Yue Pan, Lianzhi Cui, Madi Sun, Dan Shao, Mingqiang Li, Kan He, Ming Zhang, Jing Li, Li Chen
Despite the vital role miRNA-27a plays in driving the development and progress of liver cancer, miRNA-based inhibition therapy is hampered due to its undesired degradation and off-target effects. Herein, a multifunctional nanoparticle for noninvasive tracking of targeted delivery of anti-miR-27a oligonucleotides against liver cancer was constructed. Methods: Dual-fluorescent conjugates (QD-HA-PEI) were first fabricated through crosslinking hyaluronic acid (HA), polyethyleneimine (PEI) and near-infrared (NIR) fluorescent quantum dots (QDs) via a facile one-pot approach...
2018: Theranostics
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